28 results on '"Bharath Rajagopalan"'
Search Results
2. Heart Rhythm Society Communications Committee update
- Author
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Faisal M. Merchant, Devender N. Akula, Melinda J. Barber, Kristie Coleman, Piotr Futyma, Sandeep Gautam, Eric M. Grubman, Jodie L. Hurwitz, Oliver J. Monfredi, Daniel P. Morin, Bharath Rajagopalan, Martin K. Stiles, Roderick Tung, Firas Zahwe, and Janet K. Han
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
3. Surviving sudden cardiac arrest—successes, challenges, and opportunities
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Valentina Kutyifa, Dhanunjaya Lakkireddy, Luigi Di Biase, Win Kuang Shen, Bharath Rajagopalan, Rakesh Gopinathannair, Andrea Natale, Kristin Patton, and Amin Al-Ahmad
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business.industry ,medicine.medical_treatment ,Big data ,Sudden cardiac arrest ,030204 cardiovascular system & hematology ,Public access defibrillator ,EMS response ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Common cause and special cause ,Physiology (medical) ,Medicine ,030212 general & internal medicine ,Cardiopulmonary resuscitation ,Medical emergency ,Knowledge dissemination ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Sudden cardiac arrest (SCA) is the most common cause of death in the world. This manuscript highlights the various challenges in prevention and early management of SCA and also discusses the current state of SCA awareness. The manuscript also outlines the various national and international initiatives in improving SCA awareness and their impact on improving outcomes in SCA. Various campaigns have strived for widespread dissemination of cardiopulmonary resuscitation training and advocated for broader public access defibrillator availability. Finally, the manuscript describes future directions including harnessing technology with voice command and artificial intelligence to allow lay person deliver effective CPR, to improve EMS response times, and to allow wider CPR knowledge dissemination in schools and places of employment. Future research should be focused on optimizing SCA outcomes among vulnerable populations and minorities. Advancements in resuscitation science and use of big data for improvement of EMS services will improve outcomes in SCA.
- Published
- 2021
4. Laser Beam Scanning (LBS) technologies to solve AR challenges
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Bharath Rajagopalan
- Published
- 2022
5. STMicroelectronics: Laser Beam Scanning: The Ideal Solution for AR Wearable Applications
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Bharath Rajagopalan
- Subjects
Materials science ,business.industry ,Optoelectronics ,Wearable computer ,Ideal solution ,business ,Laser beams - Published
- 2021
6. Drug-Induced Arrhythmias: A Scientific Statement From the American Heart Association
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Bharath Rajagopalan, Jacinthe Leclerc, Kristen Bova Campbell, Jose A. Joglar, Mina K. Chung, Muhammad Hammadah, and James E. Tisdale
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Tachycardia ,medicine.medical_specialty ,Torsades de pointes ,030204 cardiovascular system & hematology ,QT interval ,Sudden cardiac death ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Physiology (medical) ,Internal medicine ,medicine ,cardiovascular diseases ,030212 general & internal medicine ,Atrial tachycardia ,Brugada syndrome ,business.industry ,Arrhythmias, Cardiac ,Atrial fibrillation ,American Heart Association ,medicine.disease ,United States ,cardiovascular system ,Cardiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Atrial flutter - Abstract
Many widely used medications may cause or exacerbate a variety of arrhythmias. Numerous antiarrhythmic agents, antimicrobial drugs, psychotropic medications, and methadone, as well as a growing list of drugs from other therapeutic classes (neurological drugs, anticancer agents, and many others), can prolong the QT interval and provoke torsades de pointes. Perhaps less familiar to clinicians is the fact that drugs can also trigger other arrhythmias, including bradyarrhythmias, atrial fibrillation/atrial flutter, atrial tachycardia, atrioventricular nodal reentrant tachycardia, monomorphic ventricular tachycardia, and Brugada syndrome. Some drug-induced arrhythmias (bradyarrhythmias, atrial tachycardia, atrioventricular node reentrant tachycardia) are significant predominantly because of their symptoms; others (monomorphic ventricular tachycardia, Brugada syndrome, torsades de pointes) may result in serious consequences, including sudden cardiac death. Mechanisms of arrhythmias are well known for some medications but, in other instances, remain poorly understood. For some drug-induced arrhythmias, particularly torsades de pointes, risk factors are well defined. Modification of risk factors, when possible, is important for prevention and risk reduction. In patients with nonmodifiable risk factors who require a potentially arrhythmia-inducing drug, enhanced electrocardiographic and other monitoring strategies may be beneficial for early detection and treatment. Management of drug-induced arrhythmias includes discontinuation of the offending medication and following treatment guidelines for the specific arrhythmia. In overdose situations, targeted detoxification strategies may be needed. Awareness of drugs that may cause arrhythmias and knowledge of distinct arrhythmias that may be drug-induced are essential for clinicians. Consideration of the possibility that a patient’s arrythmia could be drug-induced is important.
- Published
- 2020
7. Surviving sudden cardiac arrest-successes, challenges, and opportunities
- Author
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Bharath, Rajagopalan, Win Kuang, Shen, Kristin, Patton, Valentina, Kutyifa, Luigi, Di Biase, Amin, Al-Ahmad, Andrea, Natale, Rakesh, Gopinathannair, and Dhanunjaya, Lakkireddy
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Emergency Medical Services ,Death, Sudden, Cardiac ,Artificial Intelligence ,Humans ,Cardiopulmonary Resuscitation ,Defibrillators ,Heart Arrest - Abstract
Sudden cardiac arrest (SCA) is the most common cause of death in the world. This manuscript highlights the various challenges in prevention and early management of SCA and also discusses the current state of SCA awareness. The manuscript also outlines the various national and international initiatives in improving SCA awareness and their impact on improving outcomes in SCA. Various campaigns have strived for widespread dissemination of cardiopulmonary resuscitation training and advocated for broader public access defibrillator availability. Finally, the manuscript describes future directions including harnessing technology with voice command and artificial intelligence to allow lay person deliver effective CPR, to improve EMS response times, and to allow wider CPR knowledge dissemination in schools and places of employment. Future research should be focused on optimizing SCA outcomes among vulnerable populations and minorities. Advancements in resuscitation science and use of big data for improvement of EMS services will improve outcomes in SCA.
- Published
- 2020
8. How to Manage Patients With Cardiac Implantable Electronic Devices Undergoing Radiation Therapy
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Bénédicte Lefebvre, Bharath Rajagopalan, Joseph R. Carver, Rachel Lampert, Jim W. Cheung, Daniel J. Lenihan, Michael G. Fradley, Steven J. Feigenberg, and Jennifer E. Liu
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,RT, radiation therapy ,arrhythmia ,ICD, implantable cardioverter-defibrillator ,Radiation therapy ,radiation physics ,Oncology ,Primers in Cardio-Oncology: How To ,Mini-Focus Issue: Radiation and Cardiovascular Disease ,medicine ,Photon therapy ,Electronics ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,CIED, cardiac implantable electronic device ,photon therapy - Published
- 2020
9. Guidance for cardiac electrophysiology during the COVID-19 pandemic from the Heart Rhythm Society COVID-19 Task Force; Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, American Heart Association
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Parin Patel, Jim W. Cheung, Rachel Lampert, Tyler J Gluckman, Paul J. Wang, Bharath Rajagopalan, Janet K. Han, Mohit K. Turagam, Brian Olshansky, Joseph E. Marine, Peter A. Noseworthy, Mina K. Chung, Miguel A. Leal, Elaine Wan, Kristin E. Sandau, Elizabeth S Kaufman, Alejandra Gutierrez, Dhanunjaya Lakkireddy, Rakesh Gopinathannair, Jaun Sotomonte, Lee L. Eckhardt, Kristen K. Patton, Jose A. Joglar, and Andrea M. Russo
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Clinical cardiology ,medicine.medical_treatment ,health planning guidelines ,030204 cardiovascular system & hematology ,Electrocardiography ,0302 clinical medicine ,Health care ,Pandemic ,030212 general & internal medicine ,Societies, Medical ,medicine.diagnostic_test ,Cardiac electrophysiology ,Advanced cardiac life support ,American Heart Association ,Implantable cardioverter-defibrillator ,Telemedicine ,Practice Guidelines as Topic ,Cardiology ,Medical emergency ,Cardiology and Cardiovascular Medicine ,Coronavirus Infections ,Electrophysiologic Techniques, Cardiac ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Pneumonia, Viral ,Cardiac resynchronization therapy ,virus ,03 medical and health sciences ,Betacoronavirus ,Internal medicine ,Physiology (medical) ,Consensus Reports ,medicine ,Humans ,Cardiopulmonary resuscitation ,Pandemics ,Infection Control ,business.industry ,Task force ,SARS-CoV-2 ,practice guideline ,COVID-19 ,Arrhythmias, Cardiac ,electrophysiology ,medicine.disease ,State of the Art ,Cardiopulmonary Resuscitation ,United States ,Heart Rhythm ,pathology ,Triage ,business - Abstract
Coronavirus disease 2019 (COVID-19) is a global pandemic that is wreaking havoc on the health and economy of much of human civilization. Electrophysiologists have been impacted personally and professionally by this global catastrophe. In this joint article from representatives of the Heart Rhythm Society, the American College of Cardiology, and the American Heart Association, we identify the potential risks of exposure to patients, allied healthcare staff, industry representatives, and hospital administrators. We also describe the impact of COVID-19 on cardiac arrhythmias and methods of triage based on acuity and patient comorbidities. We provide guidance for managing invasive and noninvasive electrophysiology procedures, clinic visits, and cardiac device interrogations. In addition, we discuss resource conservation and the role of telemedicine in remote patient care along with management strategies for affected patients.
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- 2020
10. Confirmation of Pulmonary Vein Isolation After Cryoablation of Atrial Fibrillation
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Bharath Rajagopalan and Christopher Madias
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Left atrium ,Atrial fibrillation ,Cryoablation ,Ablation ,medicine.disease ,Adenosine ,Pulmonary vein ,Exit Block ,medicine.anatomical_structure ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,Dormant conduction ,business ,medicine.drug - Abstract
Pulmonary vein isolation is the cornerstone for atrial fibrillation ablation. Effectiveness of pulmonary vein isolation during cryoablation is demonstrated by confirming entrance and exit block. Loss of pulmonary vein potentials during cryoablation demonstrates presence of entrance block. Exit block is confirmed by pacing from within the pulmonary veins and demonstrating lack of capture of the left atrium. Administration of adenosine can unmask dormant conduction in the pulmonary veins.
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- 2020
11. IMPACT OF NEW-ONSET ATRIAL FIBRILLATION IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PERCUTANEOUS CORONARY INTERVENTION IN RURAL AMERICA: THE STAT-HEART PROGRAM REGISTRY
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Bharath Rajagopalan, Ziad Issa, Mouna Kodali, Ramtej Atluri, and Frank V. Aguirre
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,medicine.disease ,stat ,New onset atrial fibrillation ,Elevation (emotion) ,Internal medicine ,medicine ,Cardiology ,ST segment ,In patient ,Myocardial infarction ,Rural area ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
12. Temporal Trends, Complications, and Predictors of Outcomes Among Nonagenarians Undergoing Percutaneous Coronary Intervention
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Bharath Rajagopalan, Kevin Josey, Aishwarya Bhardwaj, Zaid Said, Vasvi Singh, Mary E. Plomondon, Abhishek C. Sawant, Thomas M. Maddox, Deepak L. Bhatt, and John Corbelli
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medicine.medical_specialty ,education.field_of_study ,Framingham Risk Score ,business.industry ,medicine.medical_treatment ,Cardiogenic shock ,Population ,Percutaneous coronary intervention ,030204 cardiovascular system & hematology ,medicine.disease ,humanities ,Clinical trial ,03 medical and health sciences ,0302 clinical medicine ,Emergency medicine ,Conventional PCI ,medicine ,Physical therapy ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,education ,Veterans Affairs - Abstract
Objectives The aim of this study was to determine temporal trends, in-laboratory complications, mortality, and predictors of mortality among nonagenarians undergoing percutaneous coronary intervention (PCI). Background Nonagenarians (patients 90 years of age or older) undergoing PCI are often underrepresented in clinical trials, and their management remains challenging and controversial. Methods All veterans undergoing PCI with data recorded in the Veterans Affairs Clinical Assessment, Reporting, and Tracking program from 2005 to 2014 were evaluated. Temporal trends in the use of PCI, occurrence of in-laboratory complications, and 30-day and 1-year mortality were assessed. Using a frailty model, predictors of 30-day and 1-year mortality in nonagenarians were evaluated. Results Among all veterans undergoing PCI (n = 67,148) between 2005 and 2014, 274 (0.4%) were nonagenarians. The proportion of nonagenarians increased from 0.25% in 2008 to 0.58% in 2014. Compared with younger patients, nonagenarians had a greater risk for acute cardiogenic shock post-procedure (0.73% vs. 0.12%; p = 0.04) and no reflow (2.9% vs. 1.0%; p = 0.02). Unadjusted (10.6% vs. 1.4%; p Conclusions Nonagenarians were a small but growing population with worse 30-day and 1-year mortality. The National Cardiovascular Data Registry risk score was a strong predictor of mortality in these patients.
- Published
- 2017
13. Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
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Christopher Madias and Bharath Rajagopalan
- Subjects
medicine.medical_specialty ,Rivaroxaban ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,Clopidogrel ,Dabigatran ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Conventional PCI ,Antithrombotic ,medicine ,Cardiology ,cardiovascular diseases ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
The choice of appropriate antithrombotic therapy in patients with atrial fibrillation (AF) undergoing percutaneous coronary interventions (PCI) should be approached prudently. Careful consideration is necessary, balancing the ischemic and bleeding risk. Traditionally, triple antithrombotic therapy comprising of aspirin, a P2Y12 inhibitor, and an oral anticoagulant is associated with high bleeding rates. Recent trials have evaluated the safety and effectiveness of dual antithrombotic therapy in AF patients undergoing PCI. These studies have shown a significant reduction in bleeding with no increase in ischemic events. Clopidogrel is the preferred P2Y12 agent in the dual antithrombotic regimens. The novel oral anticoagulants (NOAC) rivaroxaban and dabigatran have been evaluated as part of dual antithrombotic therapy and are preferred options for oral anticoagulation in AF patients undergoing PCI. Studies are in progress to evaluate the role of alternate NOACs in this clinical scenario. This review explores the contemporary management of antithrombotic therapy in AF patients undergoing PCI.
- Published
- 2019
14. The Supply and Demand of the Cardiovascular Workforce
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Bharath Rajagopalan, Michael W. Cullen, Varsha K. Tanguturi, Natalie Jayaram, Aaron P. Kithcart, Shashank S. Sinha, Nkechinyere N. Ijioma, and Akhil Narang
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Gerontology ,ComputingMilieux_THECOMPUTINGPROFESSION ,ComputerSystemsOrganization_COMPUTERSYSTEMIMPLEMENTATION ,Demographics ,business.industry ,education ,Cardiovascular care ,Disease ,030204 cardiovascular system & hematology ,Supply and demand ,03 medical and health sciences ,0302 clinical medicine ,Balance (accounting) ,Workforce ,Health care ,Medicine ,Disease prevention ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
As the burden of cardiovascular disease in the United States continues to increase, uncertainty remains on how well-equipped the cardiovascular workforce is to meet the challenges that lie ahead. In a time when health care is rapidly shifting, numerous factors affect the supply and demand of the cardiovascular workforce. This Council Commentary critically examines several factors that influence the cardiovascular workforce. These include current workforce demographics and projections, evolving health care and practice environments, and the increasing burden of cardiovascular disease. Finally, we propose 3 strategies to optimize the workforce. These focus on cardiovascular disease prevention, the effective utilization of the cardiovascular care team, and alterations to the training pathway for cardiologists.
- Published
- 2016
15. Effect of Bicarbonate-Buffered Dialysate on Ventricular Arrhythmias in Hemodialysis Patients
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Brian M. Murray, Mary Muscarella, Ryan Tulowitzki, Gregory D. Gudleski, Judy Lambert, Anne B. Curtis, Ryan E Krahn, Mandip Panesar, Winnie Su, and Bharath Rajagopalan
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Adult ,Male ,medicine.medical_specialty ,Alkalosis ,medicine.medical_treatment ,Bicarbonate ,Potassium ,030232 urology & nephrology ,Metabolic alkalosis ,Hemodynamics ,chemistry.chemical_element ,030204 cardiovascular system & hematology ,Calcium ,Acetates ,Buffers ,Sudden cardiac death ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Aged ,business.industry ,Arrhythmias, Cardiac ,Middle Aged ,medicine.disease ,Hemodialysis Solutions ,Bicarbonates ,Death, Sudden, Cardiac ,chemistry ,Nephrology ,Cardiology ,Kidney Failure, Chronic ,Female ,Hemodialysis ,business - Abstract
Background: The etiology of sudden cardiac death in patients with end-stage renal disease (ESRD) on hemodialysis (HD) is largely unknown, though there is evidence to suggest that metabolic alkalosis induced by HD with a high-bicarbonate dialysate/prescription may play a role. Methods: We investigated the effects of metabolic alkalosis induced by HD with an acetate-containing bicarbonate-buffered dialysate on frequency of ventricular arrhythmia in 47 patients with ESRD on chronic HD using 48-h Holter monitoring in 3 phases: intra-HD, post-HD day 1, and post-HD day 2. Serum levels of bicarbonate, calcium, and potassium along with hemodynamics were measured pre-HD, post-HD, 20-h post-HD, and 44-h post-HD. Correlations were performed to verify the association between bicarbonate prescription and change in serum bicarbonate levels post-HD and to determine if the HD-induced change in serum bicarbonate level (metabolic alkalosis) had any direct association with ambient ventricular arrhythmia (premature ventricular contractions per hour) or indirect associations with ambient ventricular arrhythmia by affecting electrolytes or hemodynamics that are known to increase the risk of ventricular arrhythmia. Results: Mean pre-HD serum bicarbonate level was 21.3 mEq/L. Dialysate bicarbonate prescription (mean of 36.4 mEq/L) correlated with changes in serum bicarbonate levels immediately post-HD 26.7 mEq/L (r = 0.46, p < 0.01), 20-h post-HD 25.2 mEq/L (r = 0.38), and 44-h post-HD 23.2 mEq/L (r = 0.35, p = 0.01). No statistically significant correlations were found between the post-HD change in serum bicarbonate levels (metabolic alkalosis) with ambient ventricular arrhythmia, changes in serum calcium, potassium, or hemodynamics in any phase. Conclusions: High-bicarbonate dialysate prescription is associated with metabolic alkalosis following the HD procedure. A mild metabolic alkalosis induced by HD with an acetate-containing bicarbonate-buffered dialysate solution had no direct association with ambient ventricular arrhythmia on Holter monitoring and was not associated with changes in hemodynamics or changes in serum total calcium or potassium levels. This study helps to provide guidance for the safe use of high bicarbonate dialysate/prescription in patients with ESRD on HD.
- Published
- 2018
16. Management of atrial fibrillation: What is new in the 2014 ACC/AHA/HRS guideline?
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Anne B. Curtis and Bharath Rajagopalan
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medicine.medical_specialty ,Aspirin ,business.industry ,medicine.medical_treatment ,Management of atrial fibrillation ,Guidelines as Topic ,Atrial fibrillation ,Catheter ablation ,American Heart Association ,General Medicine ,Guideline ,medicine.disease ,United States ,Atrial Fibrillation ,Heart rate ,Catheter Ablation ,medicine ,Humans ,Intensive care medicine ,business ,Anti-Arrhythmia Agents ,Stroke ,Societies, Medical ,Paroxysmal AF ,medicine.drug - Abstract
Recently, the American College of Cardiology, the American Heart Association, and the Heart Rhythm Society published an updated guideline on the management of atrial fibrillation (AF). This document is a complete revision of the 2006 guideline. Prominent changes in the 2014 guideline include the use of the CHA2DS2-VASc score for risk stratification of stroke, recommendations on when and how to use newer oral anticoagulants for thromboprophylaxis, downgrading of the use of aspirin for thromboprophylaxis of moderate-risk patients, and the use of catheter ablation in selected patients as first-line therapy for paroxysmal AF. In regard to rate control, the 2014 guideline reverts back to a previous recommendation for stricter targets for mean and maximum heart rate on therapy. The current guideline incorporates many recent trials in updating existing recommendations from the 2006 guideline. The 2014 guideline will be a vital tool in guiding physicians in the management of AF.
- Published
- 2015
17. State of Structural and Congenital Heart Disease Interventional Training in United States and Canada
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Jonathan Buber, Michael W. Cullen, Bharath Rajagopalan, and Pradeep Yadav
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medicine.medical_specialty ,Transcatheter aortic ,Heart disease ,business.industry ,medicine.medical_treatment ,Pediatric interventional cardiology ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Valve replacement ,Left atrial ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Percutaneous Mitral Valve Repair - Abstract
The field of adult and pediatric interventional cardiology (PIC) has expanded considerably over the last decade. Given the recent advances like transcatheter aortic valve replacement, percutaneous mitral valve repair, and left atrial appendage closure, many cardiology training programs are offering
- Published
- 2016
18. A New Educational Framework to Improve Lifelong Learning for Cardiologists
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Akhil Narang, David Snipelisky, Bharath Rajagopalan, Poonam Velagapudi, Aaron P. Kithcart, Bryan LeBude, and Shashank S. Sinha
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Medical education ,business.industry ,Lifelong learning ,Graduate medical education ,Cardiology ,Personalized learning ,Educational framework ,030204 cardiovascular system & hematology ,Flipped classroom ,Article ,03 medical and health sciences ,0302 clinical medicine ,Paradigm shift ,ComputingMilieux_COMPUTERSANDEDUCATION ,Medicine ,Humans ,Learning ,030212 general & internal medicine ,Adaptive learning ,Curriculum ,Cardiology and Cardiovascular Medicine ,business - Abstract
Lifelong learning is essential for the practicing cardiologist. Present lifelong learning mechanisms are stagnant and at risk for not meeting the needs of currently practicing cardiologists. With the increasing burden of cardiovascular disease, growing complexity of patient care, and ongoing pressures of nonclinical responsibilities, educational programming must evolve to meet the demands of the contemporary cardiovascular professional. A paradigm shift, replete with modern and practical educational tools, is needed in the lifelong learning armamentarium. Emerging evidence of novel educational strategies in graduate medical education supports the promise of broader application of these tools to different stages of professional life. In this commentary from the Fellows-in-Training Section Leadership Council, the authors propose 3 novel educational tools-personalized learning, adaptive learning, and the flipped classroom-to improve lifelong learning to meet the educational needs of fellows-in-training to practicing cardiologists alike.
- Published
- 2017
19. Cancer Treatment-Induced Arrhythmias: Focus on Chemotherapy and Targeted Therapies
- Author
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Bharath Rajagopalan, Anne B. Curtis, and Vitaly Buza
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Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,Decision Making ,Cardiomyopathy ,Antineoplastic Agents ,Disease ,030204 cardiovascular system & hematology ,Malignancy ,Global Health ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,Neoplasms ,medicine ,Humans ,Adverse effect ,Cardiotoxicity ,Chemotherapy ,business.industry ,Incidence ,Cancer ,Arrhythmias, Cardiac ,medicine.disease ,Radiation therapy ,030220 oncology & carcinogenesis ,Radiotherapy, Adjuvant ,Cardiology and Cardiovascular Medicine ,business - Abstract
With the development of newer drugs and improvements in established treatment protocols, prognosis for many types of cancer has improved dramatically. Some cancers that were historically associated with high fatality rates now have high cure rates or successful palliation, turning the malignancy into a chronic disease. Given this improved prognosis, more patients will face the adverse effects of cancer treatment. Cancer therapy can result in cardiac toxicity, such as cardiomyopathy. Cardiotoxicity with chemotherapeutic agents in the form of cardiomyopathy was first described in 1966 in patients receiving anthracyclines.1 However, cancer treatment–induced arrhythmia (CTIA) has not attracted specific attention until recently.2 CTIA is a complex entity with multiple factors involved in its pathogenesis. It can be divided into primary CTIA (caused by a drug disrupting specific molecular pathways critical for the development of a specific arrhythmia) and secondary CTIA (caused by damage to the endocardium/myocardium/pericardium through ischemia, inflammation, or radiation therapy (RT), with arrhythmia as a secondary phenomenon). Secondary CTIA is much more common. The distinction between primary and secondary CTIA is not well defined, with many contributing and confounding factors, and the exact mechanisms for many drugs are still to be elucidated (Figure). Figure. Mechanisms of arrhythmias in cancer patients. AC indicates anthracyclines; ATO, arsenic trioxide; HA, histamine; hERG, human Ether-a-go-go -Related Gene; PI3K, phosphotidyl inositol 3–kinase; PKI, protein kinase inhibitors; SB, sinus bradycardia; and 5-FU, 5-fluorouracil. Heart image reprinted with permission from Marieb and Hoehn.3 Copyright © 2013, Pearson Education, Inc. The incidence of CTIA with many chemotherapeutic agents is yet to be firmly established as most chemotherapy trials have not had adequate numbers of patients enrolled to study this problem. In addition, most cancer treatment trials have excluded patients with preexisting cardiac disease, which is the most vulnerable population for CTIA. The National Cancer Institute …
- Published
- 2017
20. Temporal Trends, Complications, and Predictors of Outcomes Among Nonagenarians Undergoing Percutaneous Coronary Intervention: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program
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Abhishek C, Sawant, Kevin, Josey, Mary E, Plomondon, Thomas M, Maddox, Aishwarya, Bhardwaj, Vasvi, Singh, Bharath, Rajagopalan, Zaid, Said, Deepak L, Bhatt, and John, Corbelli
- Subjects
Male ,Time Factors ,Frail Elderly ,Shock, Cardiogenic ,Coronary Artery Disease ,Kaplan-Meier Estimate ,Risk Assessment ,Percutaneous Coronary Intervention ,Risk Factors ,Odds Ratio ,Prevalence ,Humans ,Hospital Mortality ,Registries ,Non-ST Elevated Myocardial Infarction ,Aged ,Retrospective Studies ,Aged, 80 and over ,Chi-Square Distribution ,Age Factors ,Middle Aged ,United States ,United States Department of Veterans Affairs ,Logistic Models ,Treatment Outcome ,No-Reflow Phenomenon ,ST Elevation Myocardial Infarction - Abstract
The aim of this study was to determine temporal trends, in-laboratory complications, mortality, and predictors of mortality among nonagenarians undergoing percutaneous coronary intervention (PCI).Nonagenarians (patients 90 years of age or older) undergoing PCI are often underrepresented in clinical trials, and their management remains challenging and controversial.All veterans undergoing PCI with data recorded in the Veterans Affairs Clinical Assessment, Reporting, and Tracking program from 2005 to 2014 were evaluated. Temporal trends in the use of PCI, occurrence of in-laboratory complications, and 30-day and 1-year mortality were assessed. Using a frailty model, predictors of 30-day and 1-year mortality in nonagenarians were evaluated.Among all veterans undergoing PCI (n = 67,148) between 2005 and 2014, 274 (0.4%) were nonagenarians. The proportion of nonagenarians increased from 0.25% in 2008 to 0.58% in 2014. Compared with younger patients, nonagenarians had a greater risk for acute cardiogenic shock post-procedure (0.73% vs. 0.12%; p = 0.04) and no reflow (2.9% vs. 1.0%; p = 0.02). Unadjusted (10.6% vs. 1.4%; p 0.0001) and adjusted 30-day mortality (odds ratio: 2.14; 95% confidence interval [CI]: 1.42 to 3.22) and unadjusted (16.3% vs. 4.2%; p 0.0001) and adjusted 1-year mortality (odds ratio: 1.82; 95% CI: 1.27 to 2.62) were higher among PCI patients who were nonagenarians. The National Cardiovascular Data Registry risk score was highly predictive of both 30-day (hazard ratio: 2.29; 95% CI: 1.86 to 2.82) and 1-year (hazard ratio: 1.43; 95% CI: 1.07 to 1.90) mortality among nonagenarians.Nonagenarians were a small but growing population with worse 30-day and 1-year mortality. The National Cardiovascular Data Registry risk score was a strong predictor of mortality in these patients.
- Published
- 2017
21. State of Structural and Congenital Heart Disease Interventional Training in United States and Canada: An Assessment by the American College of Cardiology Fellows-in-Training Section Leadership Council
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Bharath, Rajagopalan, Jonathan, Buber, Pradeep K, Yadav, and Michael W, Cullen
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Heart Defects, Congenital ,Canada ,Leadership ,Cardiology ,United States - Published
- 2016
22. Efficacy of Intravenous Magnesium in Facilitating Cardioversion of Atrial Fibrillation
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Donald F. Switzer, Chee H. Kim, Bharath Rajagopalan, Anne B. Curtis, Zubair Shah, Ashish Bhatia, Gregory H. Gudleski, and Deepika Narasimha
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Electric Countershock ,030204 cardiovascular system & hematology ,Cardioversion ,Placebo ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Sinus rhythm ,Magnesium ,030212 general & internal medicine ,Prospective Studies ,Adverse effect ,Aged ,Electric Cardioversion ,business.industry ,Atrial fibrillation ,medicine.disease ,Hypokalemia ,Treatment Outcome ,Anesthesia ,Cardiology ,Administration, Intravenous ,Female ,Hypermagnesemia ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background— Low serum magnesium (Mg) levels are associated with an increased risk of atrial fibrillation. Some studies have shown a benefit of Mg in facilitating pharmacological cardioversion. The role of an intravenous infusion of Mg alone in facilitating electric cardioversion is not clear. Methods and Results— In a prospective, randomized, double-blind, placebo-controlled trial, we enrolled patients with atrial fibrillation who were scheduled for electric cardioversion. Patients were randomized to receive Mg or placebo before cardioversion using a step-up protocol with 75, 100, 150, and 200 J biphasic shocks. Patients with hypokalemia, hypermagnesemia, or postcardiac surgery atrial fibrillation were excluded. Patients on antiarrhythmic drugs were included as long as they were at steady state. All patients were monitored for 1 hour post procedure for the maintenance of sinus rhythm. A total of 261 patients (69% male, mean age 65.5±11.1 years) were randomized (132 and 129 patients receiving Mg and placebo, respectively). Baseline characteristics were similar between both the groups. There was no statistically significant difference in the success rate of cardioversion between the 2 groups (86.4% versus 86.0%; P =0.94), cumulative amount of energy required for successful cardioversion (123.3±55.5 versus 129.5±52.6 J; P =0.40), or the number of shocks required to convert to sinus rhythm (2.25±1.24 versus 2.41±1.22, P =0.31). No adverse events were noted in either group. Conclusions— In patients undergoing electric cardioversion for persistent atrial fibrillation, Mg infusion does not increase the rate of successful cardioversion. Clinical Trial Information— URL: https://clinicaltrials.gov . Unique identifier: NCT01597557.
- Published
- 2016
23. CONSERVATIVE MANAGEMENT OF INCIDENTALLY DIAGNOSED ALCAPA SYNDROME IN AN ASYMPTOMATIC ADULT
- Author
-
Laura Ford-Mukkamala, Bharath Rajagopalan, Zaid Said, and Shivali Malhotra
- Subjects
medicine.medical_specialty ,Conservative management ,business.industry ,CONGENITAL CARDIAC ANOMALY ,Chest pain ,Asymptomatic ,Left coronary artery ,medicine.artery ,Internal medicine ,Pulmonary artery ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Anomalous Left Coronary Artery from Pulmonary Artery (ALCAPA) is a rare and potentially fatal congenital cardiac anomaly. For adults diagnosed with ALCAPA, there is a prominent collateral system that supports the LAD when the ductus closes allowing them to survive. They may present with chest pain
- Published
- 2018
24. TOO MUCH CALCIUM, TOO LITTLE GRADIENT: AN UNUSUAL CASE OF LOW GRADIENT AORTIC STENOSIS
- Author
-
William Morris, Vijay Iyer, Bharath Rajagopalan, David Zlotnick, and Shivali Malhotra
- Subjects
medicine.medical_specialty ,Unusual case ,business.industry ,chemistry.chemical_element ,Calcium ,medicine.disease ,Stenosis ,chemistry ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,Low gradient ,business ,Cardiology and Cardiovascular Medicine - Published
- 2015
- Full Text
- View/download PDF
25. The Rise of Free Agency
- Author
-
Robert A. Peterson, Bharath Rajagopalan, and Stephen B. Watson
- Subjects
Organizational Behavior and Human Resource Management ,Sociology and Political Science ,Business ,Free agency ,Applied Psychology ,Law and economics - Published
- 2003
26. TCT-334 Predictors of Outcomes Among Nonagenarians Undergoing Percutaneous Coronary Intervention: A National Veterans Affairs Database Study
- Author
-
Kevin Josey, Meg Plomondon, John Corbelli, Ali Sheikh, Thomas M. Maddox, Abhishek C. Sawant, Bharath Rajagopalan, Zaid Said, Vasvi Singh, and Deepak L. Bhatt
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Physical therapy ,medicine ,Database study ,Percutaneous coronary intervention ,Cardiology and Cardiovascular Medicine ,business ,Veterans Affairs - Published
- 2016
27. PROPHYLACTIC IMPLANTABLE CARDIOVERTER DEFIBRILLATOR IN CARDIAC SARCOIDOSIS: SAVE A LIFE, COST A JOB?
- Author
-
Amanda Ribbeck, Robert Glover, Hiroko Beck, and Bharath Rajagopalan
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Expert consensus ,Cardiac sarcoidosis ,Implantable cardioverter-defibrillator ,Icd implantation ,Pacemaker implantation ,Granulomatous disease ,medicine ,In patient ,Cardiology and Cardiovascular Medicine ,Intensive care medicine ,business - Abstract
Cardiac sarcoidosis (CS) is a granulomatous disease that could result in life threatening arrhythmias. Recent HRS expert consensus statement recommends prophylactic ICD implantation in patients with CS who requires a pacemaker implantation for high degree AV block. A 55-year-old Caucasian
- Published
- 2016
28. MECHANICAL COMPLICATIONS OF ROBOTIC MITRAL VALVE REPAIR: VIRTUOUS INTENTIONS, MALIGN CONSEQUENCES?
- Author
-
Umesh C. Sharma, Brian Page, Bharath Rajagopalan, and William Morris
- Subjects
Mitral regurgitation ,Mitral valve repair ,medicine.medical_specialty ,Valve surgery ,business.industry ,Diabetes mellitus ,medicine.medical_treatment ,medicine ,Complication rate ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business ,Surgery - Abstract
The use of robotic valve surgery for mitral valve repair is steadily increasing. The complication rate is 1-2% in experienced centers, and much higher in less experienced centers. 73 year old Caucasian woman with a history of diabetes, hypertension, and severe mitral regurgitation underwent, what
- Published
- 2015
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