Search

Your search keyword '"Bhan, A K"' showing total 1,746 results
Start Over Author "Bhan, A K"
1,746 results on '"Bhan, A K"'

1. A Prospective Cohort Study of Novel Markers of Hepatitis B Virus Replication in Human Immunodeficiency Virus Coinfection

Author

Chung, Raymond T, King, Wendy C, Ghany, Marc G, Lisker-Melman, Mauricio, Hinerman, Amanda S, Khalili, Mandana, Sulkowski, Mark, Jain, Mamta K, Choi, Eun-Young K, Nalesnik, Michael A, Bhan, Atul K, Cloherty, Gavin, Wong, David K, Sterling, Richard K, and Network, HBV-HIV Cohort Study of the Hepatitis B Research

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Hepatitis - B, Liver Disease, Chronic Liver Disease and Cirrhosis, Clinical Research, Hepatitis, Genetics, Sexually Transmitted Infections, Infectious Diseases, HIV/AIDS, 4.1 Discovery and preclinical testing of markers and technologies, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Adult, Humans, Middle Aged, Antiviral Agents, Biomarkers, Coinfection, DNA, Viral, Hepatitis B Core Antigens, Hepatitis B e Antigens, Hepatitis B Surface Antigens, Hepatitis B virus, Hepatitis B, Chronic, HIV Infections, Prospective Studies, Virus Replication, RNA, Viral, HBcrAg, HBV, HBV RNA, HIV, Serum Biomarkers, HBV-HIV Cohort Study of the Hepatitis B Research Network, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsThe contribution of the novel biomarkers, hepatitis B virus (HBV) RNA and HBV core-related antigen (HBcrAg), to characterization of HBV-human immunodeficiency virus (HIV) coinfection is unclear. We evaluated the longitudinal dynamics of HBV RNA and HBcrAg and their association with classical HBV serum biomarkers and liver histology and viral staining.MethodsHBV-HIV co-infected adults from 8 North American centers entered a National Institutes of Health-funded prospective cohort study. Demographic, clinical, serological, and virological data were collected at entry and every 24 to 48 weeks for up to 192 weeks. Participants with HBV RNA and HBcrAg measured ≥2 times (N = 95) were evaluated; 56 had paired liver biopsies obtained at study entry and end of follow-up.ResultsParticipants had a median age of 50 years; 97% were on combination anti-viral therapy. In hepatitis B e antigen (HBeAg)+ participants, there were significant declines in HBV RNA and HBcrAg over 192 weeks that tracked with declines in HBeAg, hepatitis B surface antigen, HBV DNA, and hepatitis B core antigen (HBcAg) hepatocyte staining grade (all P < .05). In HBeAg- participants, there were not significant declines in HBV RNA (P = .49) and HBcrAg (P = .63), despite modest reductions in hepatitis B surface antigen (P < .01) and HBV DNA (P = .03). HBV serum biomarkers were not significantly related to change in hepatic activity index, Ishak fibrosis score, or hepatocyte HBcAg loss (all P > .05).ConclusionsIn HBV-HIV coinfected adults on suppressive dually active antiviral therapy, the use of novel HBV markers reveals continued improvement in suppression of HBV transcription and translation over time. The lack of further improvement in HBV serum biomarkers among HBeAg- patients suggests limits to the benefit of combination anti-viral therapy and provide rationale for additional agents with distinct mechanisms of action.

Published
2023

2. Risk of Adverse Outcomes Associated With Cardiac Sarcoidosis Diagnostic Schemes

Author

Myadam, Rahul, Crawford, Thomas C., Bogun, Frank M., Gu, Xiaokui, Ellenbogen, Kenneth A., Jasti, Shilpa, Chicos, Alexandru B., Roukoz, Henri, Zimetbaum, Peter J., Kalbfleisch, Steven J., Murgatroyd, Francis D., Steckman, David A., Rosenfeld, Lynda E., Garlitski, Ann C., Soejima, Kyoko, Bhan, Adarsh K., Vedantham, Vasanth, Dickfeld, Timm-Michael L., De Lurgio, David B., Platonov, Pyotr G., Zipse, Matthew M., Nishiuchi, Suguru, Ortman, Matthew L., Narasimhan, Calambur, Patton, Kristen K., Rosenthal, David G., Mukerji, Siddharth S., Hoogendoorn, Jarieke C., Zeppenfeld, Katja, Sauer, William H., and Kron, Jordana

Published
2023
Full Text
View/download PDF

7. Reply

Author

Myadam, Rahul, primary, Crawford, Thomas C., additional, Bogun, Frank M., additional, Gu, Xiaokui, additional, Ellenbogen, Kenneth A., additional, Jasti, Shilpa, additional, Chicos, Alexandru B., additional, Roukoz, Henri, additional, Zimetbaum, Peter J., additional, Kalbfleisch, Steven J., additional, Murgatroyd, Francis D., additional, Steckman, David A., additional, Rosenfeld, Lynda E., additional, Garlitski, Ann C., additional, Soejima, Kyoko, additional, Bhan, Adarsh K., additional, Vedantham, Vasanth, additional, Dickfeld, Timm-Michael L., additional, De Lurgio, David B., additional, Platonov, Pyotr G., additional, Zipse, Matthew M., additional, Nishiuchi, Suguru, additional, Ortman, Matthew L., additional, Narasimhan, Calambur, additional, Patton, Kristen K., additional, Rosenthal, David G., additional, Mukerji, Siddharth S., additional, Hoogendoorn, Jarieke C., additional, Zeppenfeld, Katja, additional, Sauer, William H., additional, and Kron, Jordana, additional

Published
2023
Full Text
View/download PDF

9. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions

Author

Mohanan, Vishnu, Nakata, Toru, Desch, A. Nicole, Lévesque, Chloé, Boroughs, Angela, Guzman, Gaelen, Cao, Zhifang, Creasey, Elizabeth, Yao, Junmei, Boucher, Gabrielle, Charron, Guy, Bhan, Atul K., Schenone, Monica, Carr, Steven A., Reinecker, Hans–Christian, Daly, Mark J., Rioux, John D., Lassen, Kara G., and Xavier, Ramnik J.

Published
2018

16. Monoallelic Expression of the Interleukin-2 Locus

Author

Holländer, Georg A., Zuklys, Saulius, Morel, Corinne, Mizoguchi, Emiko, Mobisson, Kathrine, Simpson, Stephen, Terhorst, Cox, Wishart, William, Golan, David E., Bhan, Atul K., and Burakoff, Steven J.

Published
1998

17. Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency

Author

Shouval, Dror S., Biswas, Amlan, Kang, Yu Hui, Griffith, Alexandra E., Konnikova, Liza, Mascanfroni, Ivan D., Redhu, Naresh S., Frei, Sandra M., Field, Michael, Doty, Andria L., Goldsmith, Jeffrey D., Bhan, Atul K., Loizides, Anthony, Weiss, Batia, Yerushalmi, Baruch, Yanagi, Tadahiro, Lui, Xiuli, Quintana, Francisco J., Muise, Aleixo M., Klein, Christoph, Horwitz, Bruce H., Glover, Sarah C., Bousvaros, Athos, and Snapper, Scott B.

Published
2016
Full Text
View/download PDF

21. Child Neurodevelopment After Multidomain Interventions From Preconception Through Early Childhood: The WINGS Randomized Clinical Trial.

Author

Upadhyay, Ravi Prakash, Taneja, Sunita, Chowdhury, Ranadip, Dhabhai, Neeta, Sapra, Savita, Mazumder, Sarmila, Sharma, Sitanshi, Tomlinson, Mark, Dua, Tarun, Chellani, Harish, Dewan, Rupali, Mittal, Pratima, Bhan, M. K., and Bhandari, Nita

Subjects
NEURODEVELOPMENTAL treatment for infants, EARLY intervention (Education), NEURAL development, CLINICAL trials, TODDLERS development, SOCIAL support, CHILD development
Abstract

Key Points: Question: How does a package of multidomain interventions addressing health, nutrition, psychosocial care and support, and environmental hygiene delivered during preconception, pregnancy, and early childhood affect child neurodevelopment at 24 months? Findings: In this second report of a randomized trial in India assessing interventions during preconception, pregnancy, and early childhood on childhood preterm births and childhood growth as primary outcomes, the secondary outcome was neurodevelopment at 24 months. Among 1712 children assessed, preconception, pregnancy, and early childhood interventions were associated with modest improvements in scores and lower incidence of moderate to severe neurodevelopmental delay in the cognitive, language, and socioemotional domains. Meaning: Multidomain interventions in the preconception period, along with those in pregnancy and early childhood, may be beneficial for child neurodevelopment. Importance: Multidomain interventions in pregnancy and early childhood have improved child neurodevelopment, but little is known about the effects of additional preconception interventions. Objective: To evaluate the effect of a multifaceted approach including health; nutrition; water, sanitation, and hygiene (WASH); and psychosocial support interventions delivered during the preconception period and/or during pregnancy and early childhood on child neurodevelopment. Design, Setting, and Participants: In this randomized trial involving low- and middle-income neighborhoods in Delhi, India, 13 500 participants were assigned to preconception interventions or routine care for the primary outcome of preterm births and childhood growth. Participants who became pregnant were randomized to pregnancy and early childhood interventions or routine care. Neurodevelopmental assessments, the trial's secondary outcome reported herein, were conducted in a subsample of children at age 24 months, including 509 with preconception, pregnancy, and early childhood interventions; 473 with preconception interventions alone; 380 with pregnancy and early childhood interventions alone; and 350 with routine care. This study was conducted from November 1, 2000, through February 25, 2022. Interventions: Health, nutrition, psychosocial care and support, and WASH interventions delivered during preconception, pregnancy, and early childhood periods. Main Outcomes and Measures: Cognitive, motor, language, and socioemotional performance at age 24 months, assessed using the Bayley Scales of Infant and Toddler Development 3 tool. Results: The mean age of participants at enrollment was 23.8 years (SD, 3.0 years). Compared with the controls at age 24 months, children in the preconception intervention groups had higher cognitive scores (mean difference [MD], 1.16; 98.3% CI, 0.18-2.13) but had similar language, motor, and socioemotional scores as controls. Those receiving pregnancy and early childhood interventions had higher cognitive (MD, 1.48; 98.3% CI, 0.49-2.46), language (MD, 2.29; 98.3% CI, 1.07-3.50), motor (MD, 1.53; 98.3% CI, 0.65-2.42), and socioemotional scores (MD, 4.15; 98.3% CI, 2.18-6.13) than did controls. The pregnancy and early childhood group also had lower incidence rate ratios (RRs) of moderate to severe delay in cognitive (incidence RR, 0.62; 98.3% CI, 0.40-0.96), language (incidence RR, 0.73; 98.3% CI, 0.57-0.93), and socioemotional (incidence RR, 0.49; 98.3% CI, 0.24-0.97) development than did those in the control group. Children in the preconception, pregnancy, and early childhood intervention group had higher cognitive (MD, 2.60; 98.3% CI, 1.08-4.12), language (MD, 3.46; 98.3% CI, 1.65-5.27), motor (MD, 2.31; 98.3% CI, 0.93-3.69), and socioemotional (MD, 5.55; 98.3% CI, 2.66-8.43) scores than did those in the control group. Conclusions and Relevance: Multidomain interventions during preconception, pregnancy and early childhood led to modest improvements in child neurodevelopment at 24 months. Such interventions for enhancing children's development warrant further evaluation. Trial Registration: Clinical Trials Registry–India CTRI/2017/06/008908 This randomized trial assesses interventions that span preconception through early childhood compared with usual care on neurodevelopment among children at age 24 months in low- and middle-income neighborhoods in India. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

22. Supplementary Tables and Figures from SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer

Author

Yigit, Burcu, primary, Wang, Ninghai, primary, ten Hacken, Elisa, primary, Chen, Shih-Shih, primary, Bhan, Atul K., primary, Suarez-Fueyo, Abel, primary, Katsuyama, Eri, primary, Tsokos, George C., primary, Chiorazzi, Nicholas, primary, Wu, Catherine J., primary, Burger, Jan A., primary, Herzog, Roland W., primary, Engel, Pablo, primary, and Terhorst, Cox, primary

Published
2023
Full Text
View/download PDF

23. Data from SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer

Author

Yigit, Burcu, primary, Wang, Ninghai, primary, ten Hacken, Elisa, primary, Chen, Shih-Shih, primary, Bhan, Atul K., primary, Suarez-Fueyo, Abel, primary, Katsuyama, Eri, primary, Tsokos, George C., primary, Chiorazzi, Nicholas, primary, Wu, Catherine J., primary, Burger, Jan A., primary, Herzog, Roland W., primary, Engel, Pablo, primary, and Terhorst, Cox, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Legends from SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer

Author

Yigit, Burcu, primary, Wang, Ninghai, primary, ten Hacken, Elisa, primary, Chen, Shih-Shih, primary, Bhan, Atul K., primary, Suarez-Fueyo, Abel, primary, Katsuyama, Eri, primary, Tsokos, George C., primary, Chiorazzi, Nicholas, primary, Wu, Catherine J., primary, Burger, Jan A., primary, Herzog, Roland W., primary, Engel, Pablo, primary, and Terhorst, Cox, primary

Published
2023
Full Text
View/download PDF

25. Supplementary Table 2 from Activation of PI3K Signaling in Merkel Cell Carcinoma

Author

Nardi, Valentina, primary, Song, Youngchul, primary, Santamaria-Barria, Juan A., primary, Cosper, Arjola K., primary, Lam, Quynh, primary, Faber, Anthony C., primary, Boland, Genevieve M., primary, Yeap, Beow Y., primary, Bergethon, Kristin, primary, Scialabba, Vanessa L., primary, Tsao, Hensin, primary, Settleman, Jeffrey, primary, Ryan, David P., primary, Borger, Darrell R., primary, Bhan, Atul K., primary, Hoang, Mai P., primary, Iafrate, Anthony J., primary, Cusack, James C., primary, Engelman, Jeffrey A., primary, and Dias-Santagata, Dora, primary

Published
2023
Full Text
View/download PDF

26. Supplementary Table 1 from Activation of PI3K Signaling in Merkel Cell Carcinoma

Author

Nardi, Valentina, primary, Song, Youngchul, primary, Santamaria-Barria, Juan A., primary, Cosper, Arjola K., primary, Lam, Quynh, primary, Faber, Anthony C., primary, Boland, Genevieve M., primary, Yeap, Beow Y., primary, Bergethon, Kristin, primary, Scialabba, Vanessa L., primary, Tsao, Hensin, primary, Settleman, Jeffrey, primary, Ryan, David P., primary, Borger, Darrell R., primary, Bhan, Atul K., primary, Hoang, Mai P., primary, Iafrate, Anthony J., primary, Cusack, James C., primary, Engelman, Jeffrey A., primary, and Dias-Santagata, Dora, primary

Published
2023
Full Text
View/download PDF

27. Data from Activation of PI3K Signaling in Merkel Cell Carcinoma

Author

Nardi, Valentina, primary, Song, Youngchul, primary, Santamaria-Barria, Juan A., primary, Cosper, Arjola K., primary, Lam, Quynh, primary, Faber, Anthony C., primary, Boland, Genevieve M., primary, Yeap, Beow Y., primary, Bergethon, Kristin, primary, Scialabba, Vanessa L., primary, Tsao, Hensin, primary, Settleman, Jeffrey, primary, Ryan, David P., primary, Borger, Darrell R., primary, Bhan, Atul K., primary, Hoang, Mai P., primary, Iafrate, Anthony J., primary, Cusack, James C., primary, Engelman, Jeffrey A., primary, and Dias-Santagata, Dora, primary

Published
2023
Full Text
View/download PDF

28. Supplementary Table 3 from Activation of PI3K Signaling in Merkel Cell Carcinoma

Author

Nardi, Valentina, primary, Song, Youngchul, primary, Santamaria-Barria, Juan A., primary, Cosper, Arjola K., primary, Lam, Quynh, primary, Faber, Anthony C., primary, Boland, Genevieve M., primary, Yeap, Beow Y., primary, Bergethon, Kristin, primary, Scialabba, Vanessa L., primary, Tsao, Hensin, primary, Settleman, Jeffrey, primary, Ryan, David P., primary, Borger, Darrell R., primary, Bhan, Atul K., primary, Hoang, Mai P., primary, Iafrate, Anthony J., primary, Cusack, James C., primary, Engelman, Jeffrey A., primary, and Dias-Santagata, Dora, primary

Published
2023
Full Text
View/download PDF

29. Supplementary Table 4 from Activation of PI3K Signaling in Merkel Cell Carcinoma

Author

Nardi, Valentina, primary, Song, Youngchul, primary, Santamaria-Barria, Juan A., primary, Cosper, Arjola K., primary, Lam, Quynh, primary, Faber, Anthony C., primary, Boland, Genevieve M., primary, Yeap, Beow Y., primary, Bergethon, Kristin, primary, Scialabba, Vanessa L., primary, Tsao, Hensin, primary, Settleman, Jeffrey, primary, Ryan, David P., primary, Borger, Darrell R., primary, Bhan, Atul K., primary, Hoang, Mai P., primary, Iafrate, Anthony J., primary, Cusack, James C., primary, Engelman, Jeffrey A., primary, and Dias-Santagata, Dora, primary

Published
2023
Full Text
View/download PDF

30. Immunostaining for Hepatitis B Viral Antigens in Liver: Association with Clinical, Biochemical and Virologic Features of Disease

Author

Kleiner, David E., primary, Lisker‐Melman, Mauricio, additional, Wahed, Abdus S., additional, Bhan, Atul K., additional, Nalesnik, Michael A., additional, Choi, Eun‐Young K., additional, Leonard, Kelsey K., additional, Ghany, Marc G., additional, Chung, Raymond T., additional, and Di Bisceglie, Adrian M., additional

Published
2023
Full Text
View/download PDF

38. Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

Author

Shouval, Dror S., Biswas, Amlan, Goettel, Jeremy A., McCann, Katelyn, Conaway, Evan, Redhu, Naresh S., Mascanfroni, Ivan D., Al Adham, Ziad, Lavoie, Sydney, Ibourk, Mouna, Nguyen, Deanna D., Samsom, Janneke N., Escher, Johanna C., Somech, Raz, Weiss, Batia, Beier, Rita, Conklin, Laurie S., Ebens, Christen L., Santos, Fernanda G.M.S., Ferreira, Alexandre R., Sherlock, Mary, Bhan, Atul K., Müller, Werner, Mora, J. Rodrigo, Quintana, Francisco J., Klein, Christoph, Muise, Aleixo M., Horwitz, Bruce H., and Snapper, Scott B.

Published
2014
Full Text
View/download PDF

39. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

Author

Lassen, Kara G., Kuballa, Petric, Conway, Kara L., Patel, Khushbu K., Becker, Christine E., Peloquin, Joanna M., Villablanca, Eduardo J., Norman, Jason M., Liu, Ta-Chiang, Heath, Robert J., Becker, Morgan L., Fagbami, Lola, Horn, Heiko, Mercer, Johnathan, Yilmaz, Omer H., Jaffe, Jacob D., Shamji, Alykhan F., Bhan, Atul K., Carr, Steven A., Daly, Mark J., Virgin, Herbert W., Schreiber, Stuart L., Stappenbeck, Thaddeus S., and Xavier, Ramnik J.

Published
2014

44. Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection

Author

Conway, Kara L., Kuballa, Petric, Song, Joo–Hye, Patel, Khushbu K., Castoreno, Adam B., Yilmaz, Omer H., Jijon, Humberto B., Zhang, Mei, Aldrich, Leslie N., Villablanca, Eduardo J., Peloquin, Joanna M., Goel, Gautam, Lee, In–Ah, Mizoguchi, Emiko, Shi, Hai Ning, Bhan, Atul K., Shaw, Stanley Y., Schreiber, Stuart L., Virgin, Herbert W., Shamji, Alykhan F., Stappenbeck, Thaddeus S., Reinecker, Hans–Christian, and Xavier, Ramnik J.

Published
2013
Full Text
View/download PDF

46. Intestinal alkaline phosphatase prevents metabolic syndrome in mice

Author

Kaliannan, Kanakaraju, Hamarneh, Sulaiman R., Economopoulos, Konstantinos P., Alam, Sayeda Nasrin, Moaven, Omeed, Patel, Palak, Malo, Nondita S., Ray, Madhury, Abtahi, Seyed M., Muhammad, Nur, Raychowdhury, Atri, Teshager, Abeba, Mohamed, Mussa M. Rafat, Moss, Angela K., Ahmed, Rizwan, Hakimian, Shahrad, Narisawa, Sonoko, Millán, José Luis, Hohmann, Elizabeth, Warren, H. Shaw, Bhan, Atul K., Malo, Madhu S., and Hodin, Richard A.

Published
2013

50. HBV transcription and translation persist despite viral suppression in HBV‐HIV co‐infected patients on antiretroviral therapy

Author

Lisker‐Melman, Mauricio, primary, Wahed, Abdus S., additional, Ghany, Marc G., additional, Chung, Raymond T., additional, King, Wendy C., additional, Kleiner, David E., additional, Bhan, Atul K., additional, Khalili, Mandana, additional, Jain, Mamta K., additional, Sulkowski, Mark, additional, Wong, David K., additional, Cloherty, Gavin, additional, and Sterling, Richard K., additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results