Search

Your search keyword '"Bhalla, Diksha"' showing total 11 results
Start Over Author "Bhalla, Diksha"
11 results on '"Bhalla, Diksha"'

2. DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Author

Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, Wildwater, Marjolein, Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, and Wildwater, Marjolein

Abstract

SUMMARY: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied to predict developmental and reproductive toxicity (DART) and implemented into an in silico platform, called DARTpaths.AVAILABILITY AND IMPLEMENTATION: All code is available on GitHub https://github.com/Xpaths/dartpaths-app under Apache license 2.0, detailed overview with demo is available at https://www.vivaltes.com/dartpaths/.SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Published
2023

3. DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Author

IRAS OH Toxicology, Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, Wildwater, Marjolein, IRAS OH Toxicology, Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, and Wildwater, Marjolein

Published
2023

4. DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Author

Bhalla, Diksha, primary, Steijaert, Marvin N, additional, Poppelaars, Eefje S, additional, Teunis, Marc, additional, van der Voet, Monique, additional, Corradi, Marie, additional, Dévière, Elisabeth, additional, Noothout, Luke, additional, Tomassen, Wilco, additional, Rooseboom, Martijn, additional, Currie, Richard A, additional, Krul, Cyrille, additional, Pieters, Raymond, additional, van Noort, Vera, additional, and Wildwater, Marjolein, additional

Published
2022
Full Text
View/download PDF

6. Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes

Author

van der Voet, Monique, primary, Teunis, Marc, additional, Louter-van de Haar, Johanna, additional, Stigter, Nienke, additional, Bhalla, Diksha, additional, Rooseboom, Martijn, additional, Wever, Kimberley E, additional, Krul, Cyrille, additional, Pieters, Raymond, additional, Wildwater, Marjolein, additional, and van Noort, Vera, additional

Published
2021
Full Text
View/download PDF

7. Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes

Author

van der Voet, Monique, Teunis, Marc, Louter-van de Haar, Johanna, Stigter, Nienke, Bhalla, Diksha, Rooseboom, Martijn, Wever, Kimberley E, Krul, Cyrille, Pieters, Raymond, Wildwater, Marjolein, van Noort, Vera, van der Voet, Monique, Teunis, Marc, Louter-van de Haar, Johanna, Stigter, Nienke, Bhalla, Diksha, Rooseboom, Martijn, Wever, Kimberley E, Krul, Cyrille, Pieters, Raymond, Wildwater, Marjolein, and van Noort, Vera

Abstract

Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence the test outcomes and thus affect the confidence in the predictive value of the organisms used as an alternative for mammals. Although test guidelines are common for mammalian studies, they are scarce for non-vertebrate organisms that would allow for the 3Rs of animal testing. Here, we present a set of 30 reporting criteria as the basis for such a guideline for Developmental and Reproductive Toxicology (DART) testing in the nematode Caenorhabditis elegans. Small organisms like C. elegans are upcoming in new approach methodologies for hazard assessment; thus, reliable and robust test protocols are urgently needed. A literature assessment of the fulfilment of the reporting criteria demonstrates that although studies describe methodological details, essential information such as compound purity and lot/batch number or type of container is often not reported. The formulated set of reporting criteria for C. elegans testing can be used by (i) researchers to describe essential experimental details (ii) data scientists that aggregate information to assess data quality and include data in aggregated databases (iii) regulators to assess study data for inclusion in regulatory hazard assessment of chemicals.

Published
2021

8. Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes

Author

Voet, Monique van der, Teunis, Marc, Louter-van de Haar, Johanna, Stigter, Nienke, Bhalla, Diksha, Rooseboom, Martijn, Wever, K.E., Wildwater, Marjolein, Noort, Vera van, Voet, Monique van der, Teunis, Marc, Louter-van de Haar, Johanna, Stigter, Nienke, Bhalla, Diksha, Rooseboom, Martijn, Wever, K.E., Wildwater, Marjolein, and Noort, Vera van

Abstract

Item does not contain fulltext

Published
2021

9. Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes

Author

IRAS OH Toxicology, dIRAS RA-1, van der Voet, Monique, Teunis, Marc, Louter-van de Haar, Johanna, Stigter, Nienke, Bhalla, Diksha, Rooseboom, Martijn, Wever, Kimberley E, Krul, Cyrille, Pieters, Raymond, Wildwater, Marjolein, van Noort, Vera, IRAS OH Toxicology, dIRAS RA-1, van der Voet, Monique, Teunis, Marc, Louter-van de Haar, Johanna, Stigter, Nienke, Bhalla, Diksha, Rooseboom, Martijn, Wever, Kimberley E, Krul, Cyrille, Pieters, Raymond, Wildwater, Marjolein, and van Noort, Vera

Published
2021

10. Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegansand other nematodes

Author

van der Voet, Monique, Teunis, Marc, Louter-van de Haar, Johanna, Stigter, Nienke, Bhalla, Diksha, Rooseboom, Martijn, Wever, Kimberley E, Krul, Cyrille, Pieters, Raymond, Wildwater, Marjolein, and van Noort, Vera

Abstract

Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence the test outcomes and thus affect the confidence in the predictive value of the organisms used as an alternative for mammals. Although test guidelines are common for mammalian studies, they are scarce for non-vertebrate organisms that would allow for the 3Rs of animal testing.Here, we present a set of 30 reporting criteria as the basis for such a guideline for Developmental and Reproductive Toxicology (DART) testing in the nematode Caenorhabditis elegans. Small organisms like C. elegansare upcoming in new approach methodologies for hazard assessment; thus, reliable and robust test protocols are urgently needed. A literature assessment of the fulfilment of the reporting criteria demonstrates that although studies describe methodological details, essential information such as compound purity and lot/batch number or type of container is often not reported. The formulated set of reporting criteria for C. eleganstesting can be used by (i) researchers to describe essential experimental details (ii) data scientists that aggregate information to assess data quality and include data in aggregated databases (iii) regulators to assess study data for inclusion in regulatory hazard assessment of chemicals.

Published
2021
Full Text
View/download PDF

11. DARTpaths, an in silico platform to investigate molecular mechanisms of compounds.

Author

Bhalla D, Steijaert MN, Poppelaars ES, Teunis M, van der Voet M, Corradi M, Dévière E, Noothout L, Tomassen W, Rooseboom M, Currie RA, Krul C, Pieters R, van Noort V, and Wildwater M

Subjects
Software, Algorithms
Abstract

Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied to predict developmental and reproductive toxicity (DART) and implemented into an in silico platform, called DARTpaths., Availability and Implementation: All code is available on GitHub https://github.com/Xpaths/dartpaths-app under Apache license 2.0, detailed overview with demo is available at https://www.vivaltes.com/dartpaths/., Supplementary Information: Supplementary data are available at Bioinformatics online., (© The Author(s) 2022. Published by Oxford University Press.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results