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Background: Cannabinoids such as cannabidiol (CBD) exhibit anti-inflammatory properties and have the potential to act as a therapeutic following mild traumatic brain injury. There is limited evidence available on the pharmacological, physiological and psychological effects of escalating CBD dosages in a healthy, male, university athlete population. Furthermore, no dosing regimen for CBD is available with implications of improving physiological function. This study will develop an optimal CBD dose based on the pharmacokinetic data in contact-sport athletes. The physiological and psychological data will be correlated to the pharmacokinetic data to understand the mechanism(s) associated with an escalating CBD dose. Methods/design: Forty participants will receive escalating doses of CBD ranging from 5 mg CBD/kg/day to 30 mg CBD/kg/day. The CBD dose is escalated every two weeks in increments of 5 mg CBD/kg/day. Participants will provide blood for pharmacological assessments at each of the 10 visits. Participants will complete a physiological assessment at each of the visits, including assessments of cerebral hemodynamics, blood pressure, electrocardiogram, seismocardiogram, transcranial magnetic stimulation, and salivary analysis for genomic sequencing. Finally, participants will complete a psychological assessment consisting of sleep, anxiety, and pain-related questionnaires. Discussion: This study will develop of an optimal CBD dose based on pharmacological, physiological, and psychological properties for future use during contact sport seasons to understand if CBD can help to reduce the frequency of mild traumatic injuries and enhance recovery. Trial registration: Clinicaltrials.gov: NCT06204003. [ABSTRACT FROM AUTHOR]

Cannabidiol (CBD) can exert neuroprotective effects without being intoxicating, and in combination with [[DELTA].sup.9]-tetrahydrocannabinol (THC) CBD has shown to protect against THC psychosis. Acute concussion and post- concussion syndrome (PCS) can result in autonomic dysfunction in heart rate variability (HRV), but less information is available on blood pressure variability (BPV). Furthermore, the effects of phytocannabinoids on HRV and BPV in PCS are unknown. The purpose of this study was to observe the influence of daily administration of CBD or a combination of CBD and THC on HRV and BPV parameters in four female PCS participants. Participants completed a seated 5-min rest followed by six breaths-per-minute paced breathing protocol. Data was collected prior to phytocannabinoid intake and continued over 54 to 70 days. High frequency systolic BPV parameter increased every assessment period, unless altered due to external circumstances and symptoms. HRV parameters showed less consistent and varying responses. These results suggest that CBD can help to improve the altered autonomic dysfunction in those with PCS, and that responses to the drug administration was individualized. Double blinded, randomized controlled trials with greater sample sizes are required to better understand the influences of the varying dosages on human physiology and in PCS. Key words: cannabidiol, concussion, post-concussion syndrome, blood pressure variability. Le cannabidiol (CBD) peut produire des effets neuroprotecteurs sans intoxication, et en association avec le [[DELTA].sup.9]-tetrahydrocannabinol (THC), on a montre que le CBD peut offrir une protection contre la psychose liee au THC. La commotion cerebrale aigue et le syndrome post-commotion cerebrale (SPCC) peuvent entrainer un dysfonctionnement autonomique quant a la variabilite de la frequence cardiaque (VFC), mais la variabilite de la tension arterielle (VTA) est moins bien documentee. En outre, on ne connait pas les effets des phytocannabinoides sur la VFC et la VTA dans le SPCC. Cette etude avait pour but d'observer l'influence de l'administration quotidienne de CBD seul ou en association avec le THC sur des parametres de la VFC et de la VTA chez quatre participantes presentant un SPCC. Les participantes se sont pliees a un repos en position assise de 5 minutes suivi d'un protocole respiratoire a une cadence de 6 respirations par minute. Nous avons recueilli les donnees avant l'absorption d'un phytocannabinoide et poursuivi sur 54 a 70 jours. Les parametres de hautes frequences des quant a la VTA systolique augmentaient a toutes les periodes d'evaluation, a moins d'etre modifiees en raison de circonstances externes et de symptomes. Les parametres de la VFC se sont montres moins constants avec des reactions moins variables. Ces resultats laissent entendre que le CBD pourrait contribuer a attenuer le dysfonctionnement autonomique chez les sujets presentant un SPCC, et que les reactions a l'administration du medicament seraient differentes d'un sujet a l'autre. Il faudrait proceder a des essais controles a double insu avec repartition aleatoire sur de plus grands echantillons pour mieux comprendre les influences des divers protocoles d'administration sur la physiologie humaine et dans le SPCC. [Traduit par la Redaction] Mots-cles: cannabidiol, commotion cerebrale, syndrome post-commotion cerebrale, variabilite de la tension arterielle., Introduction Cannabidiol (CBD) has received increased attention for its neuroprotective and anti-inflammatory effects (Devinsky et al. 2014) due to its non-intoxicating medicinal properties. [[DELTA].sup.9]- tetrahydrocannabinol (THC) is another major compound [...]