Search

Your search keyword '"Bhadauria D"' showing total 165 results
Start Over Author "Bhadauria D"
165 results on '"Bhadauria D"'

1. Novel Th17 Lymphocyte Populations, Th17.1 and PD1+Th17, are Increased in Takayasu Arteritis, and Both Th17 and Th17.1 Sub-Populations Associate with Active Disease

Author

Singh K, Rathore U, Rai MK, Behera MR, Jain N, Ora M, Bhadauria D, Sharma S, Pande G, Gambhir S, Nath A, Kumar S, Sharma A, Agarwal V, and Misra DP

Subjects
arteritis, aortic arch syndromes, pd-1 protein, drug resistance, corticosteroid, fibrosis., Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Kritika Singh,1,* Upendra Rathore,1,* Mohit Kumar Rai,1 Manas R Behera,2 Neeraj Jain,3 Manish Ora,4 Dharmendra Bhadauria,2 Supriya Sharma,5 Gaurav Pande,6 Sanjay Gambhir,4 Alok Nath,7 Sudeep Kumar,8 Aman Sharma,9 Vikas Agarwal,1 Durga Prasanna Misra1 1Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, 226014, India; 2Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, 226014, India; 3Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, 226014, India; 4Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, 226014, India; 5Department of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, 226014, India; 6Department of Medical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, 226014, India; 7Department of Pulmonary Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, 226014, India; 8Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, 226014, India; 9Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India*These authors contributed equally to this workCorrespondence: Durga Prasanna Misra, Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, India, Tel +91 5222495273, Fax + 91 522-2668812, Email DurgapMisra@gmail.comPurpose: We evaluated T helper lymphocyte profile, including novel Th17 subsets Th17.1 (secrete IFN-γ, associate with corticosteroid resistance) and PD1+Th17 (secrete TGF-β 1, implicated in fibrosis), and related cytokines in peripheral blood of Takayasu arteritis (TAK).Materials and Methods: We evaluated circulating Th1, Th2, Th17, Th17.1, PD1+CD4+ T lymphocytes, PD1+Th17, and Treg lymphocytes, inflammatory (IFN-γ, IL-4, IL-6, IL-17A, IL-23, IL-1β, TNF-α) and regulatory (IL-10, TGF-β 1) cytokines in peripheral blood of TAK (n = 57; median age 35 (interquartile range 26– 45) years; 40 females) in a cross-sectional design. We studied inflammatory and regulatory cytokines in culture supernatant of peripheral blood mononuclear cells (PBMCs) from TAK following stimulation with anti-CD3/anti-CD28 and their modulation by tacrolimus (immunosuppressive) with/without tadalafil (anti-fibrotic). Furthermore, we followed up immunosuppressive-naïve active TAK (n = 16) and compared T helper lymphocyte populations and cytokines before and after immunosuppressive therapy. Healthy controls (HC, n = 21) and sarcoidosis (disease control, n = 11) were compared against TAK.Results: TAK had higher Th17, Th17.1 and PD1+Th17 lymphocytes than HC (p < 0.001), and higher PD1+CD4+ T lymphocytes than sarcoidosis (p < 0.001). Th17 lymphocytes associated with active TAK after multivariable-adjusted logistic regression (p = 0.008). TAK had greater cytokine secretion from PBMCs (IFN-γ, IL-17A, IL-10 versus HC; IL-6, TNF-α, IL-1β versus HC or sarcoidosis) (p < 0.05). In-vitro, PBMCs from TAK showed reduced secretion of all inflammatory cytokines with tacrolimus, with synergistic reduction in IL-17A, IL-6, IL-1β and IL-10 following addition of tadalafil to tacrolimus. Serial follow-up of immunosuppressive-naïve TAK (n = 16) showed reduction in serum IL-6 and TGF-β 1 (p < 0.05) and IL-6 in culture supernatant (p < 0.05) following immunosuppressive therapy.Conclusion: Novel Th17 sub-populations (Th17.1 and PD1+Th17) are elevated in TAK. Th17 lymphocytes associate with active TAK. In-vitro experiments on cultured PBMCs suggest promise for further evaluation of a combination of immunosuppressive tacrolimus with anti-fibrotic tadalafil (or other anti-fibrotic therapies) in clinical trials of TAK.Keywords: arteritis, aortic arch syndromes, PD-1 protein, drug resistance, corticosteroid, fibrosis

Published
2022

4. POS0703 RENAL ARTERY STENOSIS IS NOT ASSOCIATED WITH WORSE SURVIVAL IN TAKAYASU ARTERITIS – DATA FROM A SINGLE-CENTER RETROSPECTIVE COHORT OF 195 PATIENTS

Author

Misra, D. P., primary, Mishra, P., additional, Singh, K., additional, Rathore, U., additional, Thakare, D., additional, Jain, N., additional, Ora, M., additional, Behera, M., additional, Gamhbir, S., additional, Bhadauria, D., additional, Kumar, S., additional, and Agarwal, V., additional

Published
2023
Full Text
View/download PDF

5. POS0705 PEDIATRIC-ONSET TAKAYASU ARTERITIS ASSOCIATES WITH WORSE SURVIVAL THAN ADULT-ONSET TAKAYASU ARTERITIS – DATA FROM A SINGLE-CENTER MATCHED RETROSPECTIVE COHORT STUDY OF 191 PATIENTS

Author

Misra, D. P., primary, Thakare, D., additional, Mishra, P., additional, Rathore, U., additional, Singh, K., additional, Behera, M., additional, Jain, N., additional, Ora, M., additional, Bhadauria, D., additional, Gamhbir, S., additional, Kumar, S., additional, and Agarwal, V., additional

Published
2023
Full Text
View/download PDF

25. Optimization of Treatment Modality in Elderly End-stage Renal Disease Population: Peritoneal Dialysis versus Transplant.

Author

Kaul, A., Behera, M. R., Kishore, R., Karthikeyan, B., Bhadauria, D. S., Mishra, P., Prasad, N., Gupta, A., and Sharma, R. K.

Subjects
CARDIOVASCULAR disease related mortality, TREATMENT of chronic kidney failure, INFECTION risk factors, SURGICAL complication risk factors, CHRONIC kidney failure, MORTALITY risk factors, CONFIDENCE intervals, GRAFT versus host reaction, KIDNEY transplantation, MULTIVARIATE analysis, PERITONEAL dialysis, SERUM albumin, BODY mass index, TREATMENT effectiveness, RETROSPECTIVE studies, TERTIARY care, ODDS ratio, OLD age, PROGNOSIS
Abstract

Despite kidney transplantation (KT) being considered as the best treatment modality for end-stage renal disease (ESRD), patient and graft survival in the elderly population is poorer than younger individuals. Many authors argue that prolonged life expectancy outweighs the risk of remaining on dialysis, but few studies had compared the treatment modalities, especially with peritoneal dialysis (PD). A retrospective study was conducted at a tertiary care institute to compare outcome of elderly ESRD patients, who received KT with those continued on PD; and to evaluate the predictors of patient survival. Patient survival at 1 year was (76.2% vs. 91.1%); 5 years (53.7% vs. 21.8%); and 10 years (35.6% vs. 0.00%) among KT and PD population, respectively. Infection was the most common cause of death among KT group (35 [41.2%] vs. 34 [28.2%]) while cardiovascular mortality in PD group (55 [46.2%] vs. 7 [8.2%]). Technique survival at 1, 5, and 10 years in PD group was 92.8%, 58.5%, and 0%, respectively. Similarly, graft survival at 1, 5, and 10 years in KT group was 98.7%, 90.2%, and 90.2%, respectively. Multivariate analysis showed body mass index (BMI) (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.82-0.93, p < 0.001), and albumin (HR 0.55, 95% CI 0.37-0.80, p = 0.002) were significant predictors of survival. In the 1st year, patient survival was better in PD than KT, but after adjustment for BMI and albumin, both short-term and long-term survival in elderly KT group was better than that of PD. Hence, elderly ESRD patients should not be barred from KT just because of age. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

33. TRANSPLANTATION CLINICAL 1

Author

Schachtner, T., primary, Reinke, P., additional, Dorje, C., additional, Mjoen, G., additional, Midtvedt, K., additional, Strom, E. H., additional, Oyen, O., additional, Jenssen, T., additional, Reisaeter, A. V., additional, Smedbraaten, Y. V., additional, Sagedal, S., additional, Fagerland, M. W., additional, Hartmann, A., additional, Thiel, S., additional, Zulkarnaev, A., additional, Vatazin, A., additional, Vincenti, F., additional, Harel, E., additional, Kantor, A., additional, Thurison, T., additional, Hoyer-Hansen, G., additional, Craik, C., additional, Kute, V. B., additional, Shah, P. S., additional, Vanikar, A. V., additional, Modi, P. R., additional, Shah, P. R., additional, Gumber, M. R., additional, Patel, H. V., additional, Engineer, D. P., additional, Shah, V. R., additional, Rizvi, J., additional, Trivedi, H. L., additional, Malheiro, J., additional, Dias, L., additional, Martins, L. S., additional, Fonseca, I., additional, Pedroso, S., additional, Almeida, M., additional, Castro-Henriques, A., additional, Cabrita, A., additional, Costa, C., additional, Ritta, M., additional, Sinesi, F., additional, Sidoti, F., additional, Mantovani, S., additional, Di Nauta, A., additional, Messina, M., additional, Cavallo, R., additional, Verflova, A., additional, Svobodova, E., additional, Slatinska, J., additional, Slavcev, A., additional, Pokorna, E., additional, Viklicky, O., additional, Yagan, J., additional, Chandraker, A., additional, Diena, D., additional, Tognarelli, G., additional, Ranghino, A., additional, Bussolino, S., additional, Fop, F., additional, Segoloni, G. P., additional, Biancone, L., additional, Leone, F., additional, Mauro, M. V., additional, Gigliotti, P., additional, Lofaro, D., additional, Greco, F., additional, Perugini, D., additional, Papalia, T., additional, Perri, A., additional, Vizza, D., additional, Giraldi, C., additional, Bonofilgio, R., additional, Luis-Lima, S., additional, Marrero, D., additional, Gonzalez-Rinne, A., additional, Torres, A., additional, Salido, E., additional, Jimenez-Sosa, A., additional, Aldea-Perona, A., additional, Gonzalez-Posada, J. M., additional, Perez-Tamajon, L., additional, Rodriguez-Hernandez, A., additional, Negrin-Mena, N., additional, Porrini, E., additional, Pihlstrom, H., additional, Dahle, D. O., additional, Holdaas, H., additional, Von Der Lippe, N., additional, Waldum, B., additional, Brekke, F., additional, Amro, A., additional, Os, I., additional, Klin, P., additional, Sanabria, H., additional, Bridoux, P., additional, De Francesco, J., additional, Fortunato, R. M., additional, Raffaele, P., additional, Kong, J., additional, Son, S. H., additional, Kwon, H. Y., additional, Whang, E. J., additional, Choi, W. Y., additional, Yoon, C. S., additional, Thanaraj, V., additional, Theakstone, A., additional, Stopper, K., additional, Ferraro, A., additional, Bhattacharjya, S., additional, Devonald, M., additional, Williams, A., additional, Mella, A., additional, Gallo, E., additional, Di Vico, M. C., additional, Pagani, F., additional, Gai, M., additional, Cho, H. J., additional, Nho, K. W., additional, Park, S.-K., additional, Kim, S. B., additional, Yoshida, K., additional, Ishii, D., additional, Ohyama, T., additional, Kohguchi, D., additional, Takeuchi, Y., additional, Varga, A., additional, Sandor, B., additional, Kalmar-Nagy, K., additional, Toth, A., additional, Toth, K., additional, Szakaly, P., additional, Kildushevsky, A., additional, Fedulkina, V., additional, Kantaria, R., additional, Staeck, O., additional, Halleck, F., additional, Rissling, O., additional, Naik, M., additional, Neumayer, H.-H., additional, Budde, K., additional, Khadzhynov, D., additional, Bhadauria, D., additional, Kaul, A., additional, Prasad, N., additional, Sharma, R. K., additional, Sezer, S., additional, Bal, Z., additional, Erkmen Uyar, M., additional, Guliyev, O., additional, Erdemir, B., additional, Colak, T., additional, Ozdemir, N., additional, Haberal, M., additional, Caliskan, Y., additional, Yazici, H., additional, Artan, A. S., additional, Oto, O. A., additional, Aysuna, N., additional, Bozfakioglu, S., additional, Turkmen, A., additional, Yildiz, A., additional, Sever, M. S., additional, Yagisawa, T., additional, Nukui, A., additional, Kimura, T., additional, Nannmoku, K., additional, Kurosawa, A., additional, Sakuma, Y., additional, Miki, A., additional, Damiano, F., additional, Ligabue, G., additional, De Biasi, S., additional, Granito, M., additional, Cossarizza, A., additional, Cappelli, G., additional, Henriques, A. C., additional, Davide, J., additional, Von During, M. E., additional, Jenssen, T. G., additional, Bollerslev, J., additional, Godang, K., additional, Asberg, A., additional, Bachelet, T., additional, Martinez, C., additional, Bello, A., additional, Kejji, S., additional, Couzi, L., additional, Guidicelli, G., additional, Lepreux, S., additional, Visentin, J., additional, Congy-Jolivet, N., additional, Rostaing, L., additional, Taupin, J.-L., additional, Kamar, N., additional, Merville, P., additional, Ozdemir, H., additional, Yildirim, S., additional, Tutal, E., additional, Sayin, B., additional, Ozdemir Acar, N., additional, Banasik, M., additional, Boratynska, M., additional, Koscielska-Kasprzak, K., additional, Kaminska, D., additional, Bartoszek, D., additional, Mazanowska, O., additional, Krajewska, M., additional, Zmonarski, S., additional, Chudoba, P., additional, Dawiskiba, T., additional, Protasiewicz, M., additional, Halon, A., additional, Sas, A., additional, Kaminska, M., additional, Klinger, M., additional, Stefanovic, N., additional, Cvetkovic, T., additional, Velickovic - Radovanovic, R., additional, Jevtovic - Stoimenov, T., additional, Vlahovic, P., additional, Rungta, R., additional, Das, P., additional, Ray, D. S., additional, Gupta, S., additional, Kolonko, A., additional, Szotowska, M., additional, Kuczera, P., additional, Chudek, J., additional, Wiecek, A., additional, Sikora-Grabka, E., additional, Adamczak, M., additional, Madej, P., additional, Amanova, A., additional, Kendi Celebi, Z., additional, Bakar, F., additional, Caglayan, M. G., additional, Keven, K., additional, Massimetti, C., additional, Imperato, G., additional, Zampi, G., additional, De Vincenzi, A., additional, Fabbri, G. D. D., additional, Brescia, F., additional, Feriozzi, S., additional, Filipov, J. J., additional, Zlatkov, B. K., additional, Dimitrov, E. P., additional, Svinarov, D. A., additional, Poesen, R., additional, De Vusser, K., additional, Evenepoel, P., additional, Kuypers, D., additional, Naesens, M., additional, Meijers, B., additional, Kocak, H., additional, Yilmaz, V. T., additional, Yilmaz, F., additional, Uslu, H. B., additional, Aliosmanoglu, I., additional, Ermis, H., additional, Dinckan, A., additional, Cetinkaya, R., additional, Ersoy, F. F., additional, Suleymanlar, G., additional, Oliveira, J.-C., additional, Santos, J., additional, Lobato, L., additional, Mendonca, D., additional, Watarai, Y., additional, Yamamoto, T., additional, Tsujita, M., additional, Hiramitsu, T., additional, Goto, N., additional, Narumi, S., additional, Kobayashi, T., additional, Line, P.-D., additional, Housawi, A., additional, House, A., additional, Ng, C., additional, Denesyk, K., additional, Rehman, F., additional, Moist, L., additional, Musetti, C., additional, Battista, M., additional, Izzo, C., additional, Guglielmetti, G., additional, Airoldi, A., additional, Stratta, P., additional, Cena, T., additional, Quaglia, M., additional, Fenoglio, R., additional, Cagna, D., additional, Amoroso, A., additional, Palmisano, A., additional, Degli Antoni, A. M., additional, Vaglio, A., additional, Piotti, G., additional, Cremaschi, E., additional, Buzio, C., additional, Maggiore, U., additional, Lee, M.-C., additional, Hsu, B.-G., additional, Zalamea Jarrin, F., additional, Sanchez Sobrino, B., additional, Lafuente Covarrubias, O., additional, Karsten Alvarez, S., additional, Dominguez Apinaniz, P., additional, Llopez Carratala, R., additional, Portoles Perez, J., additional, Yildirim, T., additional, Yilmaz, R., additional, Turkmen, E., additional, Altindal, M., additional, Arici, M., additional, Altun, B., additional, Erdem, Y., additional, Dounousi, E., additional, Mitsis, M., additional, Naka, K., additional, Pappas, H., additional, Lakkas, L., additional, Harisis, H., additional, Pappas, K., additional, Koutlas, V., additional, Tzalavra, I., additional, Spanos, G., additional, Michalis, L., additional, Siamopoulos, K., additional, Iwabuchi, T., additional, Nanmoku, K., additional, Yasunaru, S., additional, Yoshikawa, M., additional, Kitamura, K., additional, Fuji, H., additional, Fujisawa, M., additional, Nishi, S., additional, Carta, P., additional, Zanazzi, M., additional, Buti, E., additional, Larti, A., additional, Caroti, L., additional, Di Maria, L., additional, Minetti, E. E., additional, Shi, Y., additional, Luo, L., additional, Cai, B., additional, Wang, T., additional, Zou, Y., additional, Wang, L., additional, Kim, Y., additional, Kim, H. S., additional, Choi, B. S., additional, Park, C. W., additional, Yang, C. W., additional, Kim, Y.-S., additional, Chung, B. H., additional, Baek, C. H., additional, Kim, M., additional, Kim, J.-S., additional, Yang, W. S., additional, Han, D. J., additional, Mikolasevic, I., additional, Racki, S., additional, Lukenda, V., additional, Persic, M. P., additional, Colic, M., additional, Devcic, B., additional, Orlic, L., additional, Gurlek Demirci, B., additional, Say N, C. B., additional, Ozdemir Acar, F. N., additional, Vali, S., additional, Ismal, K., additional, Sahay, M., additional, Civiletti, F., additional, Cantaluppi, V., additional, Medica, D., additional, Mazzeo, A. T., additional, Assenzio, B., additional, Mastromauro, I., additional, Deambrosis, I., additional, Giaretta, F., additional, Fanelli, V., additional, Mascia, L., additional, Gkirdis, I., additional, Bechlioulis, A., additional, Evangelou, D., additional, Zarzoulas, F., additional, Kotsia, A., additional, Balafa, O., additional, Tzeltzes, G., additional, Nakas, G., additional, Kalaitzidis, R., additional, Katsouras, C., additional, Uyanik, S., additional, Toprak, S. K., additional, Ilhan, O., additional, Ekmen Uyar, M., additional, Hernandez Vargas, H., additional, Artamendi Larranaga, M., additional, Ramalle Gomara, E., additional, Gil Catalinas, F., additional, Bello Ovalle, A., additional, Pimentel Guzman, G., additional, Coloma Lopez, A., additional, Sierra Carpio, M., additional, Gil Paraiso, A., additional, Dall Anesse, C., additional, Beired Val, I., additional, Huarte Loza, E., additional, Choy, B. Y., additional, Kwan, L., additional, Mok, M., additional, Chan, T. M., additional, Yamakawa, T., additional, Kobayashi, A., additional, Yamamoto, I., additional, Mafune, A., additional, Nakada, Y., additional, Tannno, Y., additional, Tsuboi, N., additional, Yamamoto, H., additional, Yokoyama, K., additional, Ohkido, I., additional, Yokoo, T., additional, Luque, Y., additional, Anglicheau, D., additional, Rabant, M., additional, Clement, R., additional, Kreis, H., additional, Sartorius, A., additional, Noel, L.-H., additional, Timsit, M.-O., additional, Legendre, C., additional, Rancic, N., additional, Vavic, N., additional, Dragojevic-Simic, V., additional, Katic, J., additional, Jacimovic, N., additional, Kovacevic, A., additional, Mikov, M., additional, Veldhuijzen, N. M. H., additional, Rookmaaker, M. B., additional, Van Zuilen, A. D., additional, Nquyen, T. Q., additional, Boer, W. H., additional, Sahtout, W., additional, Ghezaiel, H., additional, Azzebi, A., additional, Ben Abdelkrim, S., additional, Guedri, Y., additional, Mrabet, S., additional, Nouira, S., additional, Ferdaws, S., additional, Amor, S., additional, Belarbia, A., additional, Zellama, D., additional, Mokni, M., additional, Achour, A., additional, Parikova, A., additional, Hanzal, V., additional, Fronek, J., additional, Orandi, B. J., additional, James, N. T., additional, Montgomery, R. A., additional, Desai, N. M., additional, Segev, D. L., additional, Fontana, F., additional, Ballestri, M., additional, and Magistroni, R., additional

Published
2014
Full Text
View/download PDF

34. PERITONEAL DIALYSIS

Author

Kratochwill, K., primary, Boehm, M., additional, Herzog, R., additional, Kuster, L., additional, Gleiss, A., additional, Aufricht, C., additional, Vychytil, A., additional, Prasad, N., additional, Singh, K., additional, Prasad, K., additional, Gupta, A., additional, Bhadauria, D., additional, Perez, J., additional, Selgas, R., additional, Prieto, M., additional, Sanchez, J. A., additional, Remon, C., additional, Latus, J., additional, Habib, S. M., additional, Kitterer, D., additional, Korte, M., additional, Ulmer, C., additional, Fritz, P., additional, Davies, S., additional, Lambie, M., additional, Alscher, M. D., additional, Betjes, M., additional, Segerer, S., additional, Braun, N., additional, Gluxam, T., additional, Becker, J., additional, and Kratochwill, K., additional

Published
2014
Full Text
View/download PDF

35. Transplantation: clinical studies - A

Author

Yildirim, T., primary, Yilmaz, R., additional, Altindal, M., additional, Turkmen, E., additional, Arici, M., additional, Altun, B., additional, Erdem, Y., additional, Guliyev, O., additional, Erkmen Uyar, M., additional, Tutal, E., additional, Bal, Z., additional, Sezer, S., additional, Bal, U., additional, Say n, B., additional, Erdemir, B., additional, O'Rourke-Potowki, A., additional, Gauge, N., additional, Penny, H., additional, Cronin, A., additional, Frame, S., additional, Goldsmith, D. J., additional, Yagan, J. A., additional, Chandraker, A., additional, Velickovic Radovanovic, R. M., additional, Catic Djordjevic, A., additional, Mitic, B., additional, Stefanovic, N., additional, Cvetkovic, T., additional, Serpieri, N., additional, Grosjean, F., additional, Sileno, G., additional, Torreggiani, M., additional, Esposito, V., additional, Mangione, F., additional, Abelli, M., additional, Castoldi, F., additional, Catucci, D., additional, Esposito, C., additional, Dal Canton, A., additional, Vatazin, A. V., additional, Zulkarnaev, A. B., additional, Borst, C., additional, Liu, Y., additional, Thoning, J., additional, Tepel, M., additional, Libetta, C., additional, Margiotta, E., additional, Borettaz, I., additional, Canevari, M., additional, Martinelli, C., additional, Lainu, E., additional, Meloni, F., additional, Sepe, V., additional, Miguel Costa, R., additional, Vasquez Martul, E., additional, Reboredo, J., additional, Rivera, C., additional, Simonato, F., additional, Tognarelli, G., additional, Daidola, G., additional, Gallo, E., additional, Burdese, M., additional, Cantaluppi, V., additional, Biancone, L., additional, Segoloni, G. P., additional, Priora, M., additional, Messina, M., additional, Tamagnone, M., additional, Linsalata, A., additional, Lavacca, A., additional, Segoloni, G., additional, Zuidema, W., additional, Erdman, R., additional, van de Wetering, J., additional, Dor, F., additional, Roodnat, J., additional, Massey, E., additional, Timmerman, L., additional, IJzermans, J., additional, Weimar, W., additional, Sibley-Allen, C., additional, Hilton, R., additional, Moghul, M., additional, Burnapp, L., additional, Blake, G., additional, Koo, T. Y., additional, Park, J.-S., additional, Park, H. C., additional, Kim, G.-H., additional, Lee, C. H., additional, Oh, I. H., additional, Kang, C. M., additional, Hwang, J. K., additional, Park, S. C., additional, Choi, B. S., additional, Chun, H. J., additional, Kim, J. I., additional, Yang, C. W., additional, Moon, I. S., additional, Van Laecke, S., additional, Van Biesen, W., additional, Nagler, E. V., additional, Taes, Y., additional, Peeters, P., additional, Vanholder, R., additional, Pruthi, R., additional, Ravanan, R., additional, Casula, A., additional, Harber, M., additional, Roderick, P., additional, Fogarty, D., additional, Cho, A., additional, Shin, J.-h., additional, Jang, H. R., additional, Lee, J. E., additional, Huh, W., additional, Kim, D. J. K., additional, Oh, H. Y., additional, Kim, Y.-G., additional, Sancho Calabuig, A., additional, Gavela Martinez, E., additional, Kanter Berga, J., additional, Beltran Catalan, S., additional, Avila Bernabeu, A. I., additional, Pallardo Mateu, L. M., additional, Gonzalez, E., additional, Polanco, N., additional, Molina, M., additional, Gutierrez, E., additional, Garcia Puente, L., additional, Sevillano, A., additional, Morales, E., additional, Praga, M., additional, Andres, A., additional, Banasik, M., additional, Boratynska, M., additional, Koscielska-Kasprzak, K., additional, Bartoszek, D., additional, Myszka, M., additional, Zmonarski, S., additional, Nowakowska, B., additional, Wawrzyniak, E., additional, Halon, A., additional, Chudoba, P., additional, Klinger, M., additional, Rojas-Rivera, J., additional, Morales, J. M., additional, Egido, J., additional, Kopecky, C. M., additional, Haidinger, M., additional, Kaltenecker, C., additional, Antlanger, M., additional, Marsche, G., additional, Holzer, M., additional, Kovarik, J., additional, Werzowa, J., additional, Hecking, M., additional, Saemann, M. D., additional, Kim, J. M., additional, Koh, E. S., additional, Chung, B. H., additional, Kim, Y. S., additional, Krajewska, M., additional, Mazanowska, O., additional, Kaminska, D., additional, Zabinska, M., additional, Malkiewicz, B., additional, Patrzalek, D., additional, Sulowicz, J., additional, Szostek, S., additional, Wojas-Pelc, A., additional, Ignacak, E., additional, Sulowicz, W., additional, Bellizzi, V., additional, Calella, P., additional, Cupisti, A., additional, Capitanini, A., additional, D'Alessandro, C., additional, Giannese, D., additional, Camocardi, A., additional, Conte, G., additional, Barsotti, M., additional, Bilancio, G., additional, Luciani, R., additional, Locsey, L., additional, Seres, I., additional, Kovacs, D., additional, Asztalos, L., additional, Paragh, G., additional, Wohlfahrtova, M., additional, Balaz, P., additional, Rokosny, S., additional, Wohlfahrt, P., additional, Bartonova, A., additional, Viklicky, O., additional, Kers, J., additional, Geskus, R. B., additional, Meijer, L. J., additional, Bemelman, F., additional, ten Berge, I. J. M., additional, Florquin, S., additional, Hwang, J.-C., additional, Jiang, M.-Y., additional, Lu, Y.-H., additional, Weng, S.-F., additional, Testa, A., additional, Porto, G., additional, Sanguedolce, M., additional, Spoto, B., additional, Parlongo, R., additional, Pisano, A., additional, Enia, G., additional, Tripepi, G., additional, Zoccali, C., additional, Mamode, N., additional, Lennerling, A., additional, Citterio, F., additional, Van Assche, K., additional, Sterckx, S., additional, Frunza, M., additional, Jung, H., additional, Pascalev, A., additional, Johnson, R., additional, Loven, C., additional, Soleymanian, T., additional, Keyvani, H., additional, Jazayeri, S. M., additional, Fazeli, Z., additional, Ghamari, S., additional, Mahabadi, M., additional, Chegeni, V., additional, Najafi, I., additional, Ganji, M. R., additional, Meys, K. M. E., additional, Groothoff, J. W., additional, Jager, K., additional, Schaefer, F., additional, Tonshoff, B., additional, Mota, C., additional, Cransberg, K., additional, van Stralen, K., additional, Gurluler, E., additional, Gures, N., additional, Alim, A., additional, Gurkan, A., additional, Cakir, U., additional, Berber, I., additional, Caluwe, R., additional, Nagler, E., additional, Van Vlem, B., additional, Betkowska-Prokop, A., additional, Kuzniewski, M., additional, Krzanowski, M., additional, Masson, I., additional, Flamant, M., additional, Maillard, N., additional, Cavalier, E., additional, Moranne, O., additional, Alamartine, E., additional, Mariat, C., additional, Delanaye, P., additional, Canas Sole, L. L., additional, Iglesias Alvarez, E., additional, Pastor, M. C. M. C., additional, Moreno Flores, F. F., additional, Abujder, V. V., additional, Graterol, F. F., additional, Bonet Sol, J. J., additional, Lauzurica Valdemoros, R. R., additional, Yoshikawa, M., additional, Kitamura, K., additional, Nakai, K., additional, Goto, S., additional, Fujii, H., additional, Ishimura, T., additional, Takeda, M., additional, Fujisawa, M., additional, Nishi, S., additional, Prasad, N., additional, Gurjer, D., additional, Bhadauria, D., additional, Gupta, A., additional, Sharma, R., additional, Kaul, A., additional, Cybulla, M., additional, West, M., additional, Nicholls, K., additional, Torras, J., additional, Sunder-Plassmann, G., additional, Feriozzi, S., additional, Lo, S., additional, Wong, P. Y. H., additional, Ip, D., additional, Wong, C. K., additional, Chow, V. C. C., additional, Mo, S. K. L., additional, Molnar, M., additional, Ujszaszi, A., additional, Czira, M. E., additional, Novak, M., additional, Mucsi, I., additional, Cruzado, J. M., additional, Coelho, S., additional, Porta, N., additional, Bestard, O., additional, Melilli, E., additional, Taco, O., additional, Rivas, I., additional, Grinyo, J., additional, Pouteau, L.-M., additional, N'Guyen, J.-M., additional, Hami, A., additional, Hourmant, M., additional, Ghahramani, N., additional, Karparvar, Z., additional, Shadrou, S., additional, Ghahramani, M., additional, Fauvel, J. P., additional, Hadj-Aissa, A., additional, Buron, F., additional, Morelon, E., additional, Ducher, M., additional, Heine, C., additional, Glander, P., additional, Neumayer, H.-H., additional, Budde, K., additional, Liefeldt, L., additional, Montero, N., additional, Webster, A. C., additional, Royuela, A., additional, Zamora, J., additional, Crespo, M., additional, Pascual, J., additional, Adema, A. Y., additional, van Dorp, W. T. H., additional, Mallat, M. J. K., additional, de Fijter, H. W., additional, Hong, Y. A., additional, Park, C. W., additional, Kim, Y.-S., additional, Suleymanlar, G., additional, Uzundurukan, Z., additional, Kapuagas , A., additional, Sencan, I., additional, Akdag, R., additional, Torio, A., additional, Mas, V., additional, Perez-Saez, M. J., additional, Mir, M., additional, Faura, A., additional, Montes-Ares, O., additional, Checa, M. D., additional, Sawinski, D., additional, Trofe-Clark, J., additional, Sparkes, T., additional, Patel, P., additional, Goral, S., additional, Bloom, R., additional, Kim, H. J., additional, Park, S. J., additional, Kim, T. H., additional, Kim, Y. W., additional, Kim, Y. H., additional, Kang, S. W., additional, Abdel Halim, M., additional, Gheith, O., additional, Al-Otaibi, T., additional, Mosaad, A., additional, Awadeen, W., additional, Said, T., additional, Nair, P., additional, and Nampoory, M. R. N., additional

Published
2013
Full Text
View/download PDF

36. Primary and secondary glomerulonephritis II

Author

Valdivia Vega, R. P., primary, Perez Carlos, J., additional, LI, X., additional, Xu, X., additional, Zhang, W., additional, Ren, H., additional, Chen, N., additional, Yorioka, N., additional, Doi, T., additional, Hirashio, S., additional, Arita, M., additional, Hirabayashi, A., additional, Tilkiyan, E., additional, Chonova, E., additional, Ronchev, Y., additional, Kumchev, E., additional, Giamalis, P., additional, Spartalis, M., additional, Stangou, M., additional, Tsouchnikas, I., additional, Moysiades, D., additional, Dimopoulou, D., additional, Garyfalos, A., additional, Efstratiadis, G., additional, Memmos, D., additional, Schonermarck, U., additional, Eichhorn, P., additional, Sitter, T., additional, Wendler, T., additional, Vielhauer, V., additional, Lederer, S., additional, Fechner, K., additional, Fischereder, M., additional, Bantis, C., additional, Heering, P., additional, Kouri, N.-M., additional, Schwandt, C., additional, Kuhr, N., additional, Ivens, K., additional, Rump, L.-C., additional, Matta, V., additional, Melis, P., additional, Conti, M., additional, Cao, R., additional, Binda, V., additional, Altieri, P., additional, Asunis, A. M., additional, Catani, W., additional, Floris, M., additional, Angioi, A., additional, Congia, M., additional, Cucca, F., additional, Minerba, L., additional, Peri, M., additional, Pani, A., additional, Beck, L. H., additional, Fervenza, F. C., additional, Bomback, A. S., additional, Ayalon, R., additional, Irazabal, M. V., additional, Eirin, A., additional, Cattran, D. C., additional, Appel, G. B., additional, Salant, D. J., additional, Santoro, D., additional, Postorino, A., additional, Costantino, G., additional, Bellinghieri, G., additional, Savica, V., additional, Weiner, M., additional, Goh, S. M., additional, Mohammad, A., additional, Eriksson, P., additional, Westman, K., additional, Selga, D., additional, Salama, A., additional, Segelmark, M., additional, Chocova, Z., additional, Hruskova, Z., additional, Mareckova, H., additional, Svobodova, B., additional, Jancova, E., additional, Bednarova, V., additional, Rysava, R., additional, Tesar, V., additional, Hanzal, V., additional, Zamboch, K., additional, Grussmannova, M., additional, Svojanovsky, J., additional, Klaboch, J., additional, Kubisova, M., additional, Sevcik, J., additional, Olsanska, R., additional, Sobotkova, M., additional, Becvar, R., additional, Nemec, P., additional, Kodeda, M., additional, Jilek, D., additional, Hussain, M., additional, Dhaygude, A., additional, Cartery, C., additional, Huart, A., additional, Plaisier, E., additional, Bongard, V., additional, Montastruc, F., additional, Ronco, P., additional, Pourrat, J., additional, Chauveau, D., additional, Prasad, N., additional, Gurjar, D., additional, Bhadauria, D., additional, Sharma, R. K., additional, Gupta, A., additional, Kaul, A., additional, Jain, M., additional, Venning, M., additional, Brown, N., additional, Bruce, I., additional, Noor, S., additional, Bekker, P., additional, Potarca, A., additional, Dairaghi, D., additional, Miao, S., additional, Powers, J. P., additional, Jaen, J. C., additional, Schall, T. J., additional, Kalavrizioti, D., additional, Gerolymos, M., additional, Komninakis, D., additional, Rodi, M., additional, Mouzaki, A., additional, Kalliakmani, P., additional, Goumenos, D., additional, Choi, B. S., additional, Park, C. W., additional, Kim, Y.-S., additional, Yang, C. W., additional, Sun, I. O., additional, Qin, W., additional, Xie, L., additional, Tan, C., additional, Mian, W., additional, Fu, P., additional, Kaminskyy, V., additional, Hao, X., additional, Wang, W., additional, Cengiz, C., additional, Nur, C., additional, Nurdan, Y., additional, Selman, G., additional, Pinar, T., additional, Mehmet, T., additional, Lale, S., additional, Caliskan, S., additional, Shinzawa, M., additional, Yamamoto, R., additional, Nagasawa, Y., additional, Oseto, S., additional, Mori, D., additional, Niihata, K., additional, Fukunaga, M., additional, Yamauchi, A., additional, Tsubakihara, Y., additional, Rakugi, H., additional, Isaka, Y., additional, Chen, J.-S., additional, Lin, Y.-F., additional, Lin, W.-Y., additional, Shu, K.-H., additional, Chen, H.-H., additional, Wu, C.-J., additional, Yang, C.-S., additional, Tseng, T.-L., additional, Zaza, G., additional, Bernich, P., additional, Lupo, A., additional, Panizo, N., additional, Rivera, F., additional, Lopez Gomez, J. M., additional, Regn, S. R. o. G., additional, Ceresini, G., additional, Vaglio, A., additional, Urban, M. L., additional, Corradi, D., additional, Usberti, E., additional, Palmisano, A., additional, Buzio, C., additional, Zineb, H., additional, Ramdani, B., additional, Marques, L. P. J., additional, Rioja, L. D. S., additional, Rocco, R., additional, Nery, A. C. F., additional, Novaes, B. C., additional, Bridoux, F., additional, Sicard, A., additional, Labatut, D., additional, Touchard, G., additional, Sarkozy, C., additional, Vanhille, P., additional, Callard, P., additional, Essig, M., additional, Provot, F., additional, Nony, A., additional, Karras, A., additional, Agustin, C. P., additional, M Belen, H. R., additional, Carmen, C. P., additional, Eliana, O., additional, Elisa, P., additional, Luis, P., additional, Alberto, M.-C., additional, Javier, N., additional, Isabel, F., additional, Atzeni, A., additional, Fois, A., additional, Piras, D., additional, Maxia, S., additional, Sau, G., additional, Pili, G., additional, Porcu, M., additional, Derudas, D., additional, Angelucci, E., additional, Ledda, A., additional, La Nasa, G., additional, Ossareh, S., additional, Asgari, M., additional, Savaj, S., additional, Ataipour, Y., additional, Abdi, E., additional, Malakoutian, T., additional, Rajaa, R., additional, Berkchi, F. Z., additional, Haffane, L., additional, Squalli, Z., additional, Rouass, L., additional, Al Hamany, Z., additional, Ezzaitouni, F., additional, Benamar, L., additional, Bayahya, R., additional, Ouzeddoun, N., additional, Gao-Yuan, H., additional, Yao, X., additional, Xin, C., additional, Zhen, C., additional, Yong-Chun, G., additional, Qing-Wen, W., additional, Hui-Ping, C., additional, Da-XI, J., additional, De-Hua, G., additional, Wei-Xin, H., additional, Zhi-Hong, L., additional, Fatima Zahra, B., additional, Laila, H., additional, Zoubair, S., additional, Naima, O., additional, Smykal-Jankowiak, K., additional, Niemir, Z., additional, Polcyn-Adamczak, M., additional, Szramka-Pawlak, B., additional, Zaba, R., additional, Zhang, C., additional, MA, Y., additional, Shen, P., additional, Ouyang, Y., additional, Pan, X., additional, Wang, Z., additional, Feng, X., additional, and Ni, L., additional

Published
2012
Full Text
View/download PDF

37. Diabetes - Clinical

Author

Turgutalp, K., primary, Ozhan, O., additional, Akbay, E., additional, Tiftik, N., additional, Ozcan, T., additional, Yilmaz, S., additional, Kiykim, A., additional, Wu, H.-Y., additional, Peng, Y.-S., additional, Huang, J.-W., additional, Wu, K.-D., additional, Tu, Y.-K., additional, Chien, K.-L., additional, Kacso, I. M., additional, Moldovan, D., additional, Lenghel, A., additional, Rusu, C. C., additional, Gherman Caprioara, M., additional, Silva, A. P., additional, Fragoso, A., additional, Pinho, A., additional, Silva, C., additional, Santos, N., additional, Tavares, N., additional, Faisca, M., additional, Camacho, A., additional, Mesquita, F., additional, Leao, P., additional, Rato, F., additional, Oh, D.-J., additional, Kim, H.-R., additional, Kim, S.-H., additional, Okasha, K., additional, Sweilam, M., additional, Nagy, H., additional, Hassan Rizk, M., additional, Kirkpantur, A., additional, Afsar, B., additional, Chae, D.-W., additional, Chin, H. J., additional, Kim, S., additional, Fallahzadeh Abarghouei, M. K., additional, Dormanesh, B., additional, Roozbeh, J., additional, Kamali-Sarvestani, E., additional, Vessal, G., additional, Pakfetrat, M., additional, Sagheb, M. M., additional, Imasawa, T., additional, Nishimura, M., additional, Kawaguchi, T., additional, Ishibashi, R., additional, Kitamura, H., additional, Vlad, A., additional, Petrica, L., additional, Petrica, M., additional, Jianu, D. C., additional, Gluhovschi, G., additional, Ianculescu, C., additional, Negru, M., additional, Dumitrascu, V., additional, Gadalean, F., additional, Zamfir, A., additional, Popescu, C., additional, Giju, S., additional, Gluhovschi, C., additional, Velciov, S., additional, Milas, O., additional, Balgradean, C., additional, Ursoniu, S., additional, Soltysiak, J., additional, Zachwieja, J., additional, Fichna, P., additional, Lipkowska, K., additional, Skowronska, B., additional, Stankiewicz, W., additional, Stachowiak-Lewandowska, M., additional, Kluska-Jozwiak, A., additional, Afghahi, H., additional, Prasad, N., additional, Bhadauria, D., additional, Gupta, A., additional, Sharma, R. K., additional, Kaul, A., additional, Jain, M., additional, Loboda, O., additional, Dudar, I., additional, Korol, L., additional, Shifris, I., additional, Ito, K., additional, Abe, Y., additional, Ogahara, S., additional, Yasuno, T., additional, Watanabe, M., additional, Sasatomi, Y., additional, Hisano, S., additional, Nakashima, H., additional, Saito, T., additional, Nogaibayeva, A., additional, Tuganbekova, S., additional, Taubaldiyeva, Z., additional, Bekishev, B., additional, Trimova, R., additional, Topchii, I., additional, Semenovykh, P., additional, Galchiskaya, V., additional, Efimova, N., additional, Scherban, T., additional, Yasuda, F., additional, Shimizu, A., additional, MII, A., additional, Fukui, M., additional, Postorino, M., additional, Alessi, E., additional, Dal Moro, E., additional, Postorino, S., additional, Mannino, G., additional, Giandalia, A., additional, Mannino, D., additional, Pontrelli, P., additional, Conserva, F., additional, Accetturo, M., additional, Papale, M., additional, DI Palma, A. M., additional, Cordisco, G., additional, Grandaliano, G., additional, Gesualdo, L., additional, Kimoto, E., additional, Shoji, T., additional, Sonoda, M., additional, Shima, H., additional, Tsuchikura, S., additional, Mori, K., additional, Emoto, M., additional, Ishimura, E., additional, Nishizawa, Y., additional, Inaba, M., additional, Vogel, C., additional, Scholbach, T., additional, Bergner, N., additional, Lioudaki, E., additional, Stylianou, K., additional, Maragkaki, E., additional, Stratakis, S., additional, Panteri, M., additional, Choulaki, C., additional, Vardaki, E., additional, Ganotakis, E., additional, Daphnis, E., additional, Iqbal, M., additional, Ahmed, Z., additional, Mansur, M., additional, Iqbal, S., additional, Choudhury, S., additional, Nahar, N., additional, Ali, S., additional, Ahmed, T., additional, Alam, A., additional, Rahman, Z., additional, Islam, M., additional, Azad Khan, A., additional, Ogawa, A., additional, Sugiyama, H., additional, Kitagawa, M., additional, Morinaga, H., additional, Inoue, T., additional, Takiue, K., additional, Kikumoto, Y., additional, Uchida, H. A., additional, Kitamura, S., additional, Maeshima, Y., additional, Tsuchiyama, Y., additional, Makino, H., additional, Nazemian, F., additional, Jafari, M., additional, Zahed, N. O. S., additional, Javidi Dasht Bayaz, R., additional, DI Paolo, S., additional, Vocino, G., additional, DI Palma, A., additional, Federica, C., additional, Rocchetti, M. T., additional, Prajitno, C. W., additional, Ismail, G., additional, Ditoiu, A., additional, Stanciu, S., additional, Herlea, V., additional, Motoi, O., additional, Striker, G., additional, Uribarri, J., additional, Vlassara, H., additional, Gul, B., additional, Oz Gul, O., additional, Yildiz, A., additional, Eroglu, A., additional, Keni, N., additional, Ersoy, C., additional, Ersoy, A., additional, Imamoglu, S., additional, and Yurtkuran, M., additional

Published
2012
Full Text
View/download PDF

42. Pregnancy in patients with chronic kidney disease: Maternal and fetal outcomes.

Author

Singh, R., Prasad, N., Banka, A., Gupta, A., Bhadauria, D., Sharma, R. K., and Kaul, A.

Subjects
TREATMENT of chronic kidney failure, ANALYSIS of variance, CHI-squared test, CHRONIC kidney failure, CONFIDENCE intervals, STATISTICS, T-test (Statistics), DATA analysis, TREATMENT effectiveness, RETROSPECTIVE studies, SEVERITY of illness index, DATA analysis software, DESCRIPTIVE statistics, ODDS ratio, PREGNANCY
Abstract

Chronic kidney diseases (CKD) adversely affects fetal and maternal outcomes during pregnancy. We retrospectively reviewed the renal, maternal and fetal outcomes of 51 pregnancies in women with CKD between July 2009 and January 2012. Of the 51 subjects (mean age 27.8 ± 7.04), 32 had 19 had estimated glomerular filtration rate (eGFR) <60 ml/min. There was significantly greater decline in eGFR at 6 weeks (55.8 ± 32.7 ml/min) after delivery as compared to values at conception (71.7 ± 27.6 [P < 0.001]). The average decline of GFR after 6 weeks of delivery was faster in patients with GFR < 60 ml/min/1.73 m2 at −18.8 ml/min (stage 3, n = 13, −20.2 ml/min; stage 4, n = 6, −15.8 ml/min) as compared to −15.1 ml/min in patients with GFR ≥ 60 ml/min/1.73 m2. Three of the six patients (50%) in stage 4 CKD were started on dialysis as compared to none in earlier stages of CKD (P = 0.002). At the end of 1 year, all patients in stage 4 were dialysis dependent, while only 2/13 in stage 3 were dialysis dependent (Odds ratio 59.8, 95% confidence interval 2.8-302, P = 0.001). Preeclampsia (PE) was seen in 17.6%. Only 2/32 (6.25%) patients with GFR ≥ 60 ml/min/1.73 m2 developed PE while 7/19 (36.84%) patients with GFR < 60 ml/min developed PE. Of the 51 pregnancies, 15 ended in stillbirth and 36 delivered live births. Eleven (21.56%) live‑born infants were delivered preterm and 7 (13.72%) weighed < 2,500 g. The full‑term normal delivery was significantly high (50%) in patients with GFR ≥ 60 ml/min/1.73 m2 (P = 0.006) and stillbirth was significantly high ‑ 9/19 (47.36%) patients with GFR < 60 ml/min/1.73 m2. To conclude, women with CKD stage 3 and 4 are at greater risk of decline in GFR, PE and adverse maternal and fetal outcomes as compared to women with earlier stages of CKD. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

43. Maternal, fetal and renal outcomes of pregnancy‑associated acute kidney injury requiring dialysis.

Author

Krishna, A., Singh, R., Prasad, N., Gupta, A., Bhadauria, D., Kaul, A., Sharma, R. K., and Kapoor, D.

Subjects
ACADEMIC medical centers, ACUTE kidney failure, BIOPSY, CHI-squared test, CONFIDENCE intervals, FISHER exact test, HEMODIALYSIS, T-test (Statistics), RELATIVE medical risk, TREATMENT effectiveness, RETROSPECTIVE studies, DATA analysis software, DESCRIPTIVE statistics
Abstract

Pregnancy-associated acute kidney injury (PAKI) is encountered frequently in developing countries. We evaluated the maternal, fetal and renal outcomes in women with PAKI who needed at least one session of dialysis. Of the total of 98 cases (mean age 28.85 ± 5.13 years; mean parity 2.65 ± 1.28) of PAKI, the most common cause of PAKI was postabortal sepsis. Eighteen patients died; those with oligoanuria, sepsis and central nervous system (CNS) involvement were at greater risk of mortality. The relative risk (RR) of neonatal mortality was lower after with full‑term delivery (RR: 0.17, 95% confidence interval (CI): 0.03-0.96, P = 0.02) compared to preterm delivery. Of the 80 surviving patients, 60 (75%) patients achieved complete recovery of renal function at the end of 3 months; and of the remaining 14 had presumed (n = 4) or, biopsy-proven (n = 10) acute patchy cortical necrosis. The RR of non-recovery of renal function was high (RR: 24.7, 95% CI: 3.4- 179.5) in patients who did not recover at 6 weeks. Of the 14 patients with cortical necrosis, 3 (21.42%) became independent of dialysis at 6 months. PAKI patients should be watched for dialysis independency for 6 months. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

48. Novel mutation patterns in children with steroid-resistant nephrotic syndrome.

Author

Prasad N, Meyyappan J, Dhanorkar M, Kushwaha R, Mandal K, Veeranki V, Behera M, Patel M, Yadav B, Bhadauria D, Kaul A, Yaccha M, Bhatt M, Agarwal V, and Jain M

Abstract

Background: Idiopathic nephrotic syndrome (NS) in children poses treatment challenges, with a subset developing steroid-resistant nephrotic syndrome (SRNS). Genetic factors play a role, yet data on paediatric SRNS genetics in India are scarce. We conducted a prospective study using whole-exome sequencing to explore genetic variants and their clinical correlations., Methods: A single-centre prospective study (October 2018-April 2023) enrolled children with SRNS, undergoing renal biopsy and genetic testing per institutional protocol. Clinical, histological, and genetic data were recorded. DNA isolation and next-generation sequencing were conducted for genetic analysis. Data collection included demographics, clinical parameters, and kidney biopsy findings. Syndromic features were evaluated, with second-line immunosuppressive therapy administered. Patient and renal outcomes are presented for patients with and without genetic variants., Results: A total of 680 paediatric NS patients were analysed, with 121 (17.8%) having SRNS and 96 consent to genetic analysis. 69 (71.9%) had early SRNS, 27 (28.1%) late. Among participants, 62 (64.58%) had reportable genetic variants. The most common were in COL4A genes, with 20 (31.7%) positive. Renal biopsy showed focal segmental glomerulosclerosis in 31/42 (74%) with variants, 16/28 (57.1%) without variants. Second-line immunosuppressions varied, with CNIs the most common. Outcomes varied, with partial or complete remission achieved in some while others progressed to ESRD., Conclusion: The study underscores the importance of genetic analysis in paediatric SRNS, revealing variants in 65.7% of cases. COL4A variants were predominant. Variants correlated with varied renal outcomes, highlighting potential prognostic implications. These findings emphasize the value of personalized approaches and further research in managing paediatric SRNS., Competing Interests: None declared., (© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.)

Published
2024
Full Text
View/download PDF

49. Nocardiosis in kidney transplant recipients: A tertiary care center experience.

Author

Marak R, Abdullah, Behera M, Kaul A, Bhadauria D, Prasad N, Patel M, Kushwaha R, and Yachha M

Subjects
Humans, Middle Aged, Male, Female, Retrospective Studies, Adult, India epidemiology, Opportunistic Infections epidemiology, Opportunistic Infections immunology, Opportunistic Infections microbiology, Transplant Recipients, Incidence, Graft Rejection, Nocardia Infections epidemiology, Nocardia Infections drug therapy, Nocardia Infections diagnosis, Kidney Transplantation adverse effects, Tertiary Care Centers, Nocardia
Abstract

Introduction: Kidney transplant recipients are at increased risk of opportunistic infections, including Nocardia. The incidence of nocardiosis in kidney transplant recipients is 0.4-1.3%. The data regarding its epidemiology and outcomes is limited., Methods: This was a 10-year retrospective observational study from January 2012 to December 2021 at a tertiary care center in northern India, in which all kidney transplant recipients with Nocardia infection were included and followed., Results: 12 (1.1%) patients had a Nocardia infection among the 1108 kidney transplant recipients. All were living donor kidney transplant recipients, and the mean age at diagnosis was 48.67 ± 12.60 years. Nocardia infection occurred at a median of 26 months (range 4-235) post-transplantation, with 4 (33.1%) of the cases occurring within a year of transplant. Breakthrough infection occurred in 7 (58.3%) patients on cotrimoxazole prophylaxis. 41.7% (n = 5) cases had an episode of rejection in the preceding year of Nocardia diagnosis. Concurrent cytomegalovirus (CMV) infection was present in one (8.3%) case. The lung was the most frequently involved organ. Microscopy was positive in all the cases; while culture was positive in 10 cases, and antimicrobial susceptibility testing (AST) were performed for these isolates. The majority (60%) of isolates were resistant to cotrimoxazole. All tested isolates remained susceptible to Amikacin, Imipenem, and Linezolid. No patients experienced Nocardia recurrence after completion of antibiotic therapy. The mortality at 12 months was 66.7% (n = 4), and only one death was Nocardia-related., Conclusion: Nocardia may cause a late-manifesting infection beyond the traditional window. The cotrimoxazole prophylaxis may not be sufficient for Nocardia prevention., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Published
2024
Full Text
View/download PDF

50. Micro-vascular complications of post-transplant diabetes mellitus in renal transplant recipients- an observational study.

Author

Abdullah, Momin I, Kaul A, Bhadauria D, Prasad N, Behera M, Patel M, Kushwaha R, Yachha M, and Srivastava A

Subjects
Humans, Retrospective Studies, Glycated Hemoglobin, Kidney, Proteinuria, Postoperative Complications epidemiology, Risk Factors, Transplant Recipients, Diabetes Mellitus, Type 2, Kidney Transplantation adverse effects, Diabetic Retinopathy complications, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus etiology
Abstract

Introduction: The incidence of post-transplant diabetes mellitus (PTDM) ranges from 2.5% to 20% in kidney transplant recipients. Diabetic retinopathy (DR), diabetic kidney disease (DKD), and distal symmetric polyneuropathy (DSPN) are the microvascular complications frequently seen in both type 1 and 2 diabetes mellitus (DM). However, the data regarding these complications in patients with PTDM is lacking., Method: A retrospective and prospective observational study of PTDM conducted at a tertiary care hospital from November 2018 to December 2020. 115 kidney transplant recipients who had PTDM of ≥5 years duration were included and analysed., Results: The mean duration of PTDM was 8.8 ± 3.0 years, and the mean of all available HbA1c values was 7.0 ± 0.9%. while none of the patients had evidence of diabetic retinopathy on direct ophthalmoscopy, 37.4% of patients (n = 43) had DSPN and this was associated with the duration of PTDM and age. The mean estimated glomerular filtration rate (eGFR) was 59.24 ± 21.82 ml/min/1.73m 2 , and patients had a median proteinuria of 620 mg/day (IQR 1290). Out of 115 patients, 20% of them (n = 23) underwent graft kidney biopsy, and 10 biopsies were diagnosed as de-novo DKD. Patients with biopsy proven DKD had a mean PTDM duration of 143.3 ± 52.4 months; a mean HbA1c level of 7.9 ± 1.3%; a mean eGFR of 44.8 ± 21.8 ml/min; and a median proteinuria of 2653 mg (IQR 2758). An additional analysis of all 23 biopsied patients showed that HbA1c level and degree of proteinuria were significantly associated with de-novo DKD., Conclusion: PTDM in transplant patients had milder microvascular complications than usually expected in Type 1/2 diabetes in non-transplant patients. DR was not strongly associated with DKD in PTDM patients. Furthermore, de-novo DKD development was associated with poor glycaemic control and increased proteinuria., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results