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1. Modeling the influence of the hippocampal memory system on the oculomotor system

Author

Ryan, Jennifer D., Shen, Kelly, Kacollja, Arber, Tian, Heather, Griffiths, John, Bezgin, Gleb, and McIntosh, Anthony R.

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Visual exploration is related to activity in the hippocampus (HC) and/or extended medial temporal lobe system (MTL), is influenced by stored memories, and is altered in amnesic cases. An extensive set of polysynaptic connections exists both within and between the HC and oculomotor systems such that investigating how HC responses ultimately influence neural activity in the oculomotor system, and the timing by which such neural modulation could occur, is not trivial. We leveraged TheVirtualBrain, a software platform for large-scale network simulations, to model the functional dynamics that govern the interactions between the two systems in the macaque cortex. Evoked responses following the stimulation of the MTL and some, but not all, subfields of the HC resulted in observable responses in oculomotor regions, including the frontal eye fields, within the time of a gaze fixation. Modeled lesions to some MTL regions slowed the dissipation of HC signal to oculomotor regions, whereas HC lesions generally did not affect the rapid MTL activity propagation to oculomotor regions. These findings provide a framework for investigating how information represented by the HC/MTL may influence the oculomotor system during a fixation and predict how HC lesions may affect visual exploration.

Published
2020
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2. Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer’s disease

Author

Sanchez-Rodriguez, Lazaro M, Bezgin, Gleb, Carbonell, Felix, Therriault, Joseph, Fernandez-Arias, Jaime, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Stevenson, Jenna, Karikari, Thomas K, Ashton, Nicholas J, Benedet, Andréa L, Zetterberg, Henrik, Blennow, Kaj, Triana-Baltzer, Gallen, Kolb, Hartmuth C, Rosa-Neto, Pedro, and Iturria-Medina, Yasser

Subjects
Biochemistry and Cell Biology, Biological Sciences, Clinical Research, Acquired Cognitive Impairment, Aging, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Neurosciences, Biomedical Imaging, Alzheimer's Disease, Neurodegenerative, Dementia, Aetiology, 2.1 Biological and endogenous factors, Neurological, Alzheimer Disease, Humans, tau Proteins, Amyloid beta-Peptides, Brain, Male, Female, Aged, Magnetic Resonance Imaging, Middle Aged, Positron-Emission Tomography, Models, Neurological, Biomarkers, Aged, 80 and over, Electroencephalography, Neurons, Biological sciences, Biomedical and clinical sciences
Abstract

Neuronal dysfunction and cognitive deterioration in Alzheimer's disease (AD) are likely caused by multiple pathophysiological factors. However, mechanistic evidence in humans remains scarce, requiring improved non-invasive techniques and integrative models. We introduce personalized AD computational models built on whole-brain Wilson-Cowan oscillators and incorporating resting-state functional MRI, amyloid-β (Aβ) and tau-PET from 132 individuals in the AD spectrum to evaluate the direct impact of toxic protein deposition on neuronal activity. This subject-specific approach uncovers key patho-mechanistic interactions, including synergistic Aβ and tau effects on cognitive impairment and neuronal excitability increases with disease progression. The data-derived neuronal excitability values strongly predict clinically relevant AD plasma biomarker concentrations (p-tau217, p-tau231, p-tau181, GFAP) and grey matter atrophy obtained through voxel-based morphometry. Furthermore, reconstructed EEG proxy quantities show the hallmark AD electrophysiological alterations (theta band activity enhancement and alpha reductions) which occur with Aβ-positivity and after limbic tau involvement. Microglial activation influences on neuronal activity are less definitive, potentially due to neuroimaging limitations in mapping neuroprotective vs detrimental activation phenotypes. Mechanistic brain activity models can further clarify intricate neurodegenerative processes and accelerate preventive/treatment interventions.

Published
2024

3. In-vivo neuronal dysfunction by Aβ and tau overlaps with brain-wide inflammatory mechanisms in Alzheimer’s disease

Author

Sanchez-Rodriguez, Lazaro M, Khan, Ahmed F, Adewale, Quadri, Bezgin, Gleb, Therriault, Joseph, Fernandez-Arias, Jaime, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Stevenson, Jenna, Jiang, Hongxiu, Chai, Xiaoqian, Carbonell, Felix, Rosa-Neto, Pedro, and Iturria-Medina, Yasser

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Alzheimer's Disease, Biomedical Imaging, Brain Disorders, Clinical Research, Genetics, Aging, Acquired Cognitive Impairment, Neurodegenerative, Aetiology, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Underpinning research, Neurological, Good Health and Well Being, Alzheimer’s disease, amyloid – beta, computational drug repurposing, inflammation, neuronal dysfunctions and alterations, tau and phospho-tau protein, transcriptomics, whole-brain modeling, Biochemistry and Cell Biology, Cognitive Sciences, Biological psychology
Abstract

The molecular mechanisms underlying neuronal dysfunction in Alzheimer's disease (AD) remain uncharacterized. Here, we identify genes, molecular pathways and cellular components associated with whole-brain dysregulation caused by amyloid-beta (Aβ) and tau deposits in the living human brain. We obtained in-vivo resting-state functional MRI (rs-fMRI), Aβ- and tau-PET for 47 cognitively unimpaired and 16 AD participants from the Translational Biomarkers in Aging and Dementia cohort. Adverse neuronal activity impacts by Aβ and tau were quantified with personalized dynamical models by fitting pathology-mediated computational signals to the participant's real rs-fMRIs. Then, we detected robust brain-wide associations between the spatial profiles of Aβ-tau impacts and gene expression in the neurotypical transcriptome (Allen Human Brain Atlas). Within the obtained distinctive signature of in-vivo neuronal dysfunction, several genes have prominent roles in microglial activation and in interactions with Aβ and tau. Moreover, cellular vulnerability estimations revealed strong association of microglial expression patterns with Aβ and tau's synergistic impact on neuronal activity (q

Published
2024

4. Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease

Author

Aguzzoli, Cristiano Schaffer, Ferreira, Pâmela CL, Povala, Guilherme, Ferrari-Souza, João Pedro, Bellaver, Bruna, Katz, Carolina Soares, Zalzale, Hussein, Lussier, Firoza Z, Rohden, Francieli, Abbas, Sarah, Leffa, Douglas T, Medeiros, Marina Scop, Therriault, Joseph, Benedet, Andréa L, Tissot, Cécile, Servaes, Stijn, Rahmouni, Nesrine, Macedo, Arthur Cassa, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Pallen, Vanessa, Cohen, Ann, Lopez, Oscar L, Tudorascu, Dana L, Klunk, William E, Villemagne, Victor L, Soucy, Jean Paul, Zimmer, Eduardo R, Schilling, Lucas P, Karikari, Thomas K, Ashton, Nicholas J, Zetterberg, Henrik, Blennow, Kaj, Gauthier, Serge, Valcour, Victor, Miller, Bruce L, Rosa-Neto, Pedro, and Pascoal, Tharick A

Subjects
Health Services and Systems, Health Sciences, Aging, Alzheimer's Disease, Brain Disorders, Acquired Cognitive Impairment, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Biomedical Imaging, Neurodegenerative, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Male, Humans, Female, Aged, Alzheimer Disease, Microglia, tau Proteins, Cross-Sectional Studies, Amyloid beta-Peptides, Biomarkers, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceNeuropsychiatric symptoms are commonly encountered and are highly debilitating in patients with Alzheimer disease. Understanding their underpinnings has implications for identifying biomarkers and treatment for these symptoms.ObjectiveTo evaluate whether glial markers are associated with neuropsychiatric symptoms in individuals across the Alzheimer disease continuum.Design, setting, and participantsThis cross-sectional study was conducted from January to June 2023, leveraging data from the Translational Biomarkers in Aging and Dementia cohort at McGill University, Canada. Recruitment was based on referrals of individuals from the community or from outpatient clinics. Exclusion criteria included active substance abuse, major surgery, recent head trauma, safety contraindications for positron emission tomography (PET) or magnetic resonance imaging, being currently enrolled in other studies, and having inadequately treated systemic conditions.Main outcomes and measuresAll individuals underwent assessment for neuropsychiatric symptoms (Neuropsychiatry Inventory Questionnaire [NPI-Q]), and imaging for microglial activation ([11C]PBR28 PET), amyloid-β ([18F]AZD4694 PET), and tau tangles ([18F]MK6240 PET).ResultsOf the 109 participants, 72 (66%) were women and 37 (34%) were men; the median age was 71.8 years (range, 38.0-86.5 years). Overall, 70 had no cognitive impairment and 39 had cognitive impairment (25 mild; 14 Alzheimer disease dementia). Amyloid-β PET positivity was present in 21 cognitively unimpaired individuals (30%) and in 31 cognitively impaired individuals (79%). The NPI-Q severity score was associated with microglial activation in the frontal, temporal, and parietal cortices (β = 7.37; 95% CI, 1.34-13.41; P = .01). A leave-one-out approach revealed that irritability was the NPI-Q domain most closely associated with the presence of brain microglial activation (β = 6.86; 95% CI, 1.77-11.95; P = .008). Furthermore, we found that microglia-associated irritability was associated with study partner burden measured by NPI-Q distress score (β = 5.72; 95% CI, 0.33-11.10; P = .03).Conclusions and relevanceIn this cross-sectional study of 109 individuals across the AD continuum, microglial activation was associated with and a potential biomarker of neuropsychiatric symptoms in Alzheimer disease. Moreover, our findings suggest that the combination of amyloid-β- and microglia-targeted therapies could have an impact on relieving these symptoms.

Published
2023

5. Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease

Author

Ottoy, Julie, Kang, Min Su, Tan, Jazlynn Xiu Min, Boone, Lyndon, Vos de Wael, Reinder, Park, Bo-yong, Bezgin, Gleb, Lussier, Firoza Z., Pascoal, Tharick A., Rahmouni, Nesrine, Stevenson, Jenna, Fernandez Arias, Jaime, Therriault, Joseph, Hong, Seok-Jun, Stefanovic, Bojana, McLaurin, JoAnne, Soucy, Jean-Paul, Gauthier, Serge, Bernhardt, Boris C., Black, Sandra E., Rosa-Neto, Pedro, and Goubran, Maged

Published
2024
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6. APOEε4 potentiates amyloid β effects on longitudinal tau pathology

Author

Ferrari-Souza, João Pedro, Bellaver, Bruna, Ferreira, Pâmela C. L., Benedet, Andréa L., Povala, Guilherme, Lussier, Firoza Z., Leffa, Douglas T., Therriault, Joseph, Tissot, Cécile, Soares, Carolina, Wang, Yi-Ting, Chamoun, Mira, Servaes, Stijn, Macedo, Arthur C., Vermeiren, Marie, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, Cohen, Ann, Lopez, Oscar L., Klunk, William E., Soucy, Jean-Paul, Gauthier, Serge, Souza, Diogo O., Triana-Baltzer, Gallen, Saad, Ziad S., Kolb, Hartmuth C., Karikari, Thomas K., Villemagne, Victor L., Tudorascu, Dana L., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Zimmer, Eduardo R., Rosa-Neto, Pedro, and Pascoal, Tharick A.

Published
2023
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7. Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging

Author

Macedo, Arthur C., Therriault, Joseph, Tissot, Cécile, Aumont, Étienne, Servaes, Stijn, Rahmouni, Nesrine, Fernandez-Arias, Jaime, Lussier, Firoza Z., Wang, Yi-Ting, Ng, Kok Pin, Vermeiren, Marie, Bezgin, Gleb, Socualaya, Kely Quispialaya, Stevenson, Jenna, Hosseini, Seyyed Ali, Chamoun, Mira, Ferrari-Souza, João Pedro, Ferreira, Pâmela C.L., Bellaver, Bruna, Leffa, Douglas Teixeira, Vitali, Paolo, Zimmer, Eduardo R., Ismail, Zahinoor, Pascoal, Tharick A., Gauthier, Serge, and Rosa-Neto, Pedro

Published
2024
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8. Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Author

Hansen, Justine Y., Shafiei, Golia, Markello, Ross D., Smart, Kelly, Cox, Sylvia M. L., Nørgaard, Martin, Beliveau, Vincent, Wu, Yanjun, Gallezot, Jean-Dominique, Aumont, Étienne, Servaes, Stijn, Scala, Stephanie G., DuBois, Jonathan M., Wainstein, Gabriel, Bezgin, Gleb, Funck, Thomas, Schmitz, Taylor W., Spreng, R. Nathan, Galovic, Marian, Koepp, Matthias J., Duncan, John S., Coles, Jonathan P., Fryer, Tim D., Aigbirhio, Franklin I., McGinnity, Colm J., Hammers, Alexander, Soucy, Jean-Paul, Baillet, Sylvain, Guimond, Synthia, Hietala, Jarmo, Bedard, Marc-André, Leyton, Marco, Kobayashi, Eliane, Rosa-Neto, Pedro, Ganz, Melanie, Knudsen, Gitte M., Palomero-Gallagher, Nicola, Shine, James M., Carson, Richard E., Tuominen, Lauri, Dagher, Alain, and Misic, Bratislav

Published
2022
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9. Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease

Author

Ferrari-Souza, João Pedro, Ferreira, Pâmela C. L., Bellaver, Bruna, Tissot, Cécile, Wang, Yi-Ting, Leffa, Douglas T., Brum, Wagner S., Benedet, Andréa L., Ashton, Nicholas J., De Bastiani, Marco Antônio, Rocha, Andréia, Therriault, Joseph, Lussier, Firoza Z., Chamoun, Mira, Servaes, Stijn, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, Klunk, William E., Tudorascu, Dana L., Cohen, Ann D., Villemagne, Victor L., Gauthier, Serge, Blennow, Kaj, Zetterberg, Henrik, Souza, Diogo O., Karikari, Thomas K., Zimmer, Eduardo R., Rosa-Neto, Pedro, and Pascoal, Tharick A.

Published
2022
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10. Biomarker modeling of Alzheimer’s disease using PET-based Braak staging

Author

Therriault, Joseph, Pascoal, Tharick A., Lussier, Firoza Z., Tissot, Cécile, Chamoun, Mira, Bezgin, Gleb, Servaes, Stijn, Benedet, Andrea L., Ashton, Nicholas J., Karikari, Thomas K., Lantero-Rodriguez, Juan, Kunach, Peter, Wang, Yi-Ting, Fernandez-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, and Rosa-Neto, Pedro

Published
2022
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13. Predicting functional decline in aging and Alzheimer’s disease with PET-based Braak staging

Author

Macedo, Arthur C, primary, Therriault, Joseph, additional, Tissot, Cécile, additional, Fernandez Arias, Jaime, additional, Ferreira, Pamela C L, additional, Vitali, Paolo, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Lussier, Firoza Z, additional, Stevenson, Jenna, additional, Wang, Yi-Ting, additional, Socualaya, Kely Quispialaya, additional, Kunach, Peter, additional, Nazneen, Tahnia, additional, Hosseini, Seyyed Ali, additional, Pallen, Vanessa, additional, Stevenson, Alyssa, additional, Ferrari-Souza, João Pedro, additional, Bellaver, Bruna, additional, Leffa, Douglas Teixeira, additional, Ng, Kok Pin, additional, Zimmer, Eduardo R, additional, Pascoal, Tharick A, additional, Gauthier, Serge, additional, and Rosa-Neto, Pedro, additional

Published
2024
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14. Full-density multi-scale account of structure and dynamics of macaque visual cortex

Author

Schmidt, Maximilian, Bakker, Rembrandt, Shen, Kelly, Bezgin, Gleb, Hilgetag, Claus-Christian, Diesmann, Markus, and van Albada, Sacha J.

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

We present a multi-scale spiking network model of all vision-related areas of macaque cortex that represents each area by a full-scale microcircuit with area-specific architecture. The layer- and population-resolved network connectivity integrates axonal tracing data from the CoCoMac database with recent quantitative tracing data, and is systematically refined using dynamical constraints. Simulations reveal a stable asynchronous irregular ground state with heterogeneous activity across areas, layers, and populations. Elicited by large-scale interactions, the model reproduces longer intrinsic time scales in higher compared to early visual areas. Activity propagates down the visual hierarchy, similar to experimental results associated with visual imagery. Cortico-cortical interaction patterns agree well with fMRI resting-state functional connectivity. The model bridges the gap between local and large-scale accounts of cortex, and clarifies how the detailed connectivity of cortex shapes its dynamics on multiple scales.

Published
2015
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15. In-vivo neuronal dysfunction by Aβ and tau overlaps with brain-wide inflammatory mechanisms in Alzheimer's disease.

Author

Sanchez-Rodriguez, Lazaro M., Khan, Ahmed F., Adewale, Quadri, Bezgin, Gleb, Therriault, Joseph, Fernandez-Arias, Jaime, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Stevenson, Jenna, Hongxiu Jiang, Xiaoqian Chai, Carbonell, Felix, Rosa-Neto, Pedro, and Iturria-Medina, Yasser

Subjects
BRAIN physiology, ALZHEIMER'S disease, CELL physiology, IN vivo studies, MAGNETIC resonance imaging, IMMUNE system, NEUROINFLAMMATION, MANN Whitney U Test, NERVE tissue proteins, LONGITUDINAL method, DRUG repositioning, GENE expression profiling, AGING, INFLAMMATION, COGNITION, BIOMARKERS, DISEASE complications
Abstract

The molecular mechanisms underlying neuronal dysfunction in Alzheimer's disease (AD) remain uncharacterized. Here, we identify genes, molecular pathways and cellular components associated with whole-brain dysregulation caused by amyloid-beta (Aβ) and tau deposits in the living human brain. We obtained in-vivo resting-state functional MRI (rs-fMRI), Aβ- and tau-PET for 47 cognitively unimpaired and 16 AD participants from the Translational Biomarkers in Aging and Dementia cohort. Adverse neuronal activity impacts by Aβ and tau were quantified with personalized dynamical models by fitting pathology-mediated computational signals to the participant's real rs-fMRIs. Then, we detected robust brain-wide associations between the spatial profiles of Aβ-tau impacts and gene expression in the neurotypical transcriptome (Allen Human Brain Atlas). Within the obtained distinctive signature of in-vivo neuronal dysfunction, several genes have prominent roles in microglial activation and in interactions with Aβ and tau. Moreover, cellular vulnerability estimations revealed strong association of microglial expression patterns with Aβ and tau's synergistic impact on neuronal activity (q < 0.001). These results further support the central role of the immune system and neuroinflammatory pathways in AD pathogenesis. Neuronal dysregulation by AD pathologies also associated with neurotypical synaptic and developmental processes. In addition, we identified drug candidates from the vast LINCS library to halt or reduce the observed Aβ-tau effects on neuronal activity. Top-ranked pharmacological interventions target inflammatory, cancer and cardiovascular pathways, including specific medications undergoing clinical evaluation in AD. Our findings, based on the examination of molecular-pathological-functional interactions in humans, may accelerate the process of bringing effective therapies into clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Synaptic dysfunction, Tau pathology and Neurodegeneration

Author

Soares, Carolina, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Aguzzoli, Cristiano Schaffer, additional, Rohden, Francieli, additional, Ferrari‐Souza, João Pedro, additional, Zalzale, Hussein, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R, additional, and Pascoal, Tharick A., additional

Published
2023
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18. CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration

Author

Soares, Carolina, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Aguzzoli, Cristiano Schaffer, additional, Ferrari‐Souza, João Pedro, additional, Zalzale, Hussein, additional, Lussier, Firoza Z, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R, additional, and Pascoal, Tharick A., additional

Published
2023
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19. Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer’s disease

Author

Ferrari‐Souza, João Pedro, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Benedet, Andrea Lessa, additional, Soares, Carolina, additional, Aguzzoli, Cristiano Schaffer, additional, Zalzale, Hussein, additional, Rohden, Francieli, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Souza, Diogo O., additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Triana‐Baltzer, Gallen, additional, Saad, Ziad S., additional, Kolb, Hartmuth C., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Pascoal, Tharick A., additional, and Zimmer, Eduardo R, additional

Published
2023
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20. Increased regional brain inflammation predicts longitudinal brain atrophy in individuals in the Alzheimer’s disease continuum

Author

Povala, Guilherme, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Lussier, Firoza Z, additional, Ferrari‐Souza, João Pedro, additional, Leffa, Douglas Teixeira, additional, Tissot, Cécile, additional, Therriault, Joseph, additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Benedet, Andrea Lessa, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Cohen, Ann D., additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Karikari, Thomas K, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick Ali, additional

Published
2023
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21. Plasma p‐tau and brain‐derived total tau biomarkers predict longitudinal changes in Aβ, tau, and cognition across the AD continuum

Author

Ferreira, Pamela C.L., primary, Bellaver, Bruna, additional, Povala, Guilherme, additional, Rodriguez, Juan Lantero, additional, Snellman, Anniina, additional, Leffa, Douglas Teixeira, additional, Ferrari‐Souza, Pedro, additional, Lussier, Firoza Z, additional, Zalzale, Hussein, additional, Soares, Carolina, additional, Aguzzoli, Cristiano Schaffer, additional, Tissot, Cécile, additional, Benedet, Andrea Lessa, additional, Rohden, Francieli, additional, Therriault, Joseph, additional, Abbas, Sarah, additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Lopez, Oscar L., additional, Rahmouni, Nesrine, additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Cohen, Ann D., additional, Gauthier, Serge, additional, Zimmer, Eduardo R., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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22. Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer’s Disease

Author

Aguzzoli, Cristiano Schaffer, primary, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Soares, Carolina, additional, Ferrari‐Souza, João Pedro, additional, Bellaver, Bruna, additional, Zalzale, Hussein, additional, Lussier, Firoza Z, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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23. Mapping the effects of functional and structural network reorganization on the tau‐cognition relationship in Alzheimer’s disease

Author

Ottoy, Julie, primary, Kang, Min Su, additional, de Wael, Reinder Vos, additional, Park, Bo‐Yong, additional, Bezgin, Gleb, additional, Lussier, Firoza Z, additional, Rahmouni, Nesrine, additional, Stevenson, Jenna, additional, Arias, Jaime Fernandez, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Bernhardt, Boris, additional, Black, Sandra E., additional, Rosa‐Neto, Pedro, additional, and Goubran, Maged, additional

Published
2023
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24. APOEε4 potentiates the effects of Aβ pathology on the deposition of neurofibrillary tangles via tau phosphorylation

Author

Ferrari‐Souza, João Pedro, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Benedet, Andrea Lessa, additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Soares, Carolina, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Klunk, William E, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Triana‐Baltzer, Gallen, additional, Saad, Ziad S., additional, Kolb, Hartmuth C., additional, Karikari, Thomas K, additional, Villemagne, Victor L, additional, Tudorascu, Dana, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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25. Microglial activation interacts with amyloid‐β to drive longitudinal tau tangle accumulation and cognitive decline

Author

Povala, Guilherme, primary, Bellaver, Bruna, additional, Lussier, Firoza Z, additional, Ferreira, Pamela C.L., additional, Ferrari‐Souza, João Pedro, additional, Leffa, Douglas Teixeira, additional, Aguzzoli, Cristiano Schaffer, additional, Zalzale, Hussein, additional, Soares, Carolina, additional, Abbas, Sarah, additional, Rohden, Francieli, additional, Tissot, Cécile, additional, Therriault, Joseph, additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Benedet, Andrea Lessa, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Karikari, Thomas K, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick Ali, additional

Published
2023
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26. Potential utility of using both APOEε4 and Aβ positivity to enrich clinical trials of tau‐targeting therapies

Author

Ferrari‐Souza, João Pedro, primary, Ferreira, Pamela C.L., additional, Bellaver, Bruna, additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Soares, Carolina, additional, Benedet, Andrea Lessa, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Aguzzoli, Cristiano Schaffer, additional, Zalzale, Hussein, additional, Rohden, Francieli, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Souza, Diogo O., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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27. Sex impacts the association of plasma Glial Fibrillary Acidic Protein with neurodegeneration in Alzheimer’s disease

Author

Abbas, Sarah, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Ferrari‐Souza, João Pedro, additional, Lussier, Firoza Z, additional, Zalzale, Hussein, additional, Lemaire, Peter Charles, additional, Soares, Carolina, additional, Rohden, Francieli, additional, Aguzzoli, Cristiano Schaffer, additional, Cabrera, Arlec, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Chamoun, Mira, additional, Bezgin, Gleb, additional, Stevenson, Jenna, additional, Stevenson, Alyssa, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Benedet, Andrea Lessa, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick Ali, additional

Published
2023
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28. Hippocampal subfield volumes and memory performances: associations with stimulus modality and free recall or recognition

Author

Aumont, Etienne, primary, Bussy, Aurelie, additional, Bezgin, Gleb, additional, Therriault, Joseph, additional, Savard, Melissa, additional, Arias, Jaime Fernandez, additional, Poltronetti, Nina Margherita, additional, Pallen, Vanessa, additional, Thomas, Emilie, additional, Vitali, Paolo, additional, Chakravarty, Mallar, additional, Bedard, Marc‐Andre, additional, and Rosa‐Neto, Pedro, additional

Published
2023
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29. Plasma biomarkers of tau for the differentiation between slow and fast tau‐PET accumulators

Author

Tissot, Cécile, primary, Therriault, Joseph, additional, Rahmouni, Nesrine, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Wang, Yi‐Ting, additional, Stevenson, Jenna, additional, Snellman, Anniina, additional, Rodriguez, Juan Lantero, additional, Stevenson, Alyssa, additional, Arias, Jaime Fernandez, additional, Lussier, Firoza Z, additional, Chamoun, Mira, additional, Mathotaarachchi, Sulantha, additional, Bezgin, Gleb, additional, Kunach, Peter, additional, Triana‐Baltzer, Gallen, additional, Gauthier, Serge, additional, Karikari, Thomas K, additional, Kolb, Hartmuth C., additional, Benedet, Andrea Lessa, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Pascoal, Tharick Ali, additional, Ashton, Nicholas J., additional, and Rosa‐Neto, Pedro, additional

Published
2023
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30. Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer’s Disease

Author

Aguzzoli, Cristiano Schaffer, primary, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Soares, Carolina, additional, Ferrari‐Souza, João Pedro, additional, Bellaver, Bruna, additional, Zalzale, Hussein, additional, Lussier, Firoza Z, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Poltronetti, Nina Margherita, additional, Soucy, Jean‐Paul, additional, Wang, Yi‐Ting, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Ashton, Nicholas J., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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31. Employing transfer learning to optimize deep learning models for Alzheimer’s disease classification using two tau PET tracers

Author

Bauer‐Negrini, Guilherme, primary, Povala, Guilherme, additional, Lucchese, Luisa Vieira, additional, Lussier, Firoza Z, additional, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Aguzzoli, Cristiano Schaffer, additional, Soares, Carolina, additional, Zalzale, Hussein, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Ferrari‐Souza, João Pedro, additional, Leffa, Douglas Teixeira, additional, Lemaire, Peter Charles, additional, Cabrera, Arlec, additional, Tissot, Cécile, additional, Therriault, Joseph, additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Gauthier, Serge, additional, Karikari, Thomas K, additional, Zatt, Bruno, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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32. Synaptic dysfunction in the presence of tau tangles is not a strong predictor of atrophy

Author

Soares, Carolina, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Aguzzoli, Cristiano Schaffer, additional, Rohden, Francieli, additional, Ferrari‐Souza, João Pedro, additional, Zalzale, Hussein, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R, additional, and Pascoal, Tharick A., additional

Published
2023
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33. Plasma p‐tau231 and p‐tau217 provides information on tau tangle deposition in symptomatic Alzheimer’s disease individuals

Author

Ferreira, Pamela C.L., primary, Bellaver, Bruna, additional, Povala, Guilherme, additional, Therriault, Joseph, additional, Ferrari‐Souza, João Pedro, additional, Tissot, Cécile, additional, Leffa, Douglas Teixeira, additional, Brum, Wagner S., additional, Benedet, Andrea Lessa, additional, Lussier, Firoza Z, additional, Cabrera, Arlec, additional, Zalzale, Hussein, additional, Soares, Carolina, additional, Aguzzoli, Cristiano Schaffer, additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Stevenson, Jenna, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Cohen, Ann D., additional, Gauthier, Serge, additional, Zimmer, Eduardo R., additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Karikari, Thomas K, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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34. Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease

Author

Schaffer Aguzzoli, Cristiano, primary, Ferreira, Pâmela C. L., additional, Povala, Guilherme, additional, Ferrari-Souza, João Pedro, additional, Bellaver, Bruna, additional, Soares Katz, Carolina, additional, Zalzale, Hussein, additional, Lussier, Firoza Z., additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Leffa, Douglas T., additional, Scop Medeiros, Marina, additional, Therriault, Joseph, additional, Benedet, Andréa L., additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Cassa Macedo, Arthur, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Pallen, Vanessa, additional, Cohen, Ann, additional, Lopez, Oscar L., additional, Tudorascu, Dana L., additional, Klunk, William E., additional, Villemagne, Victor L., additional, Soucy, Jean Paul, additional, Zimmer, Eduardo R., additional, Schilling, Lucas P., additional, Karikari, Thomas K., additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Gauthier, Serge, additional, Valcour, Victor, additional, Miller, Bruce L., additional, Rosa-Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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35. Hippocampal subfield associations with memory depend on stimulus modality and retrieval mode

Author

Aumont, Etienne, primary, Bussy, Aurélie, additional, Bedard, Marc-André, additional, Bezgin, Gleb, additional, Therriault, Joseph, additional, Savard, Melissa, additional, Fernandez Arias, Jaime, additional, Sziklas, Viviane, additional, Vitali, Paolo, additional, Poltronetti, Nina Margherita, additional, Pallen, Vanessa, additional, Thomas, Emilie, additional, Gauthier, Serge, additional, Kobayashi, Eliane, additional, Rahmouni, Nesrine, additional, Stevenson, Jenna, additional, Tissot, Cecile, additional, Chakravarty, Mallar M, additional, and Rosa-Neto, Pedro, additional

Published
2023
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36. Translation of monosynaptic circuits underlying amygdala fMRI neurofeedback training

Author

Trambaiolli, Lucas, Maffei, Chiara, Dann, Evan, Biazoli Jr, Claudinei, Bezgin, Gleb, Yendiki, Anastasia, and Haber, Suzanne

Abstract

fMRI neurofeedback using autobiographical memory recall to upregulate the amygdala is associated with resting-state functional connectivity (rsFC) changes between the amygdala and the salience and default mode networks (SN and DMN, respectively). We hypothesize the existence of anatomical circuits underlying these rsFC changes. Using a cross-species brain parcellation, we identified in non-human primates locations homologous to the regions of interest (ROIs) from studies showing pre-to-post-neurofeedback changes in rsFC with the left amygdala. We injected bidirectional tracers in the basolateral, lateral, and central amygdala nuclei of adult macaques and used bright- and dark-field microscopy to identify cells and axon terminals in each ROI (SN: anterior cingulate, ventrolateral, and insular cortices; DMN: temporal pole, middle frontal gyrus, angular gyrus, precuneus, posterior cingulate cortex, parahippocampal gyrus, hippocampus, and thalamus). We also performed additional injections in specific ROIs to validate the results following amygdala injections and delineate potential disynaptic pathways. Finally, we used high-resolution diffusion MRI data from four post-mortemmacaque brains and one in vivo human brain to translate our findings to the neuroimaging domain. Different amygdala nuclei had significant monosynaptic connections with all the SN and DMN ipsilateral ROIs. Amygdala connections with the DMN contralateral ROIs are disynaptic through the hippocampus and parahippocampal gyrus. Diffusion MRI in both species benefitted from using the ground-truth tracer data to validate its findings, as we identified false-negative ipsilateral and false-positive contralateral connectivity results. This study provides the foundation for future causal investigations of amygdala neurofeedback modulation of the SN and DMN through these anatomic connections.

Published
2024
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37. Stable long-range interhemispheric coordination is supported by direct anatomical projections

Author

Shen, Kelly, Mišić, Bratislav, Cipollini, Ben N, Bezgin, Gleb, Buschkuehl, Martin, Hutchison, R Matthew, Jaeggi, Susanne M, Kross, Ethan, Peltier, Scott J, Everling, Stefan, Jonides, John, McIntosh, Anthony R, and Berman, Marc G

Subjects
Biological Sciences, Ecology, Physical Sciences, 2.1 Biological and endogenous factors, Aetiology, Animals, Brain Mapping, Corpus Callosum, Female, Functional Laterality, Humans, Macaca, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Species Specificity, Synaptic Transmission, functional connectivity, structural connectivity, homotopy, dynamics
Abstract

The functional interaction between the brain's two hemispheres includes a unique set of connections between corresponding regions in opposite hemispheres (i.e., homotopic regions) that are consistently reported to be exceptionally strong compared with other interhemispheric (i.e., heterotopic) connections. The strength of homotopic functional connectivity (FC) is thought to be mediated by the regions' shared functional roles and their structural connectivity. Recently, homotopic FC was reported to be stable over time despite the presence of dynamic FC across both intrahemispheric and heterotopic connections. Here we build on this work by considering whether homotopic FC is also stable across conditions. We additionally test the hypothesis that strong and stable homotopic FC is supported by the underlying structural connectivity. Consistent with previous findings, interhemispheric FC between homotopic regions were significantly stronger in both humans and macaques. Across conditions, homotopic FC was most resistant to change and therefore was more stable than heterotopic or intrahemispheric connections. Across time, homotopic FC had significantly greater temporal stability than other types of connections. Temporal stability of homotopic FC was facilitated by direct anatomical projections. Importantly, temporal stability varied with the change in conductive properties of callosal axons along the anterior-posterior axis. Taken together, these findings suggest a notable role for the corpus callosum in maintaining stable functional communication between hemispheres.

Published
2015

39. Bayesian workflow for the investigation of hierarchical classification models from tau-PET and structural MRI data across the Alzheimer’s disease spectrum

Author

Belasso, Clyde J., primary, Cai, Zhengchen, additional, Bezgin, Gleb, additional, Pascoal, Tharick, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Tissot, Cécile, additional, Lussier, Firoza, additional, Rosa-Neto, Pedro, additional, Soucy, Jean-Paul, additional, Rivaz, Hassan, additional, and Benali, Habib, additional

Published
2023
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40. Transcriptomic signatures of Abeta- and tau-induced neuronal dysfunction reveal inflammatory processes at the core of Alzheimer's disease pathophysiology

Author

Sanchez-Rodriguez, Lazaro M, primary, Khan, Ahmed, additional, Adewale, Quadri, additional, Bezgin, Gleb, additional, Therriault, Joseph, additional, Fernandez-Arias, Jaime, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Tissot, Cecile, additional, Stevenson, Jenna, additional, Jiang, Hongxiu, additional, Chai, Xiaoqian J, additional, Carbonell, Felix, additional, Rosa-Neto, Pedro, additional, and Iturria-Medina, Yasser, additional

Published
2023
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41. Plasma p‐tau231 and p‐tau217 inform on tau tangles aggregation in cognitively impaired individuals

Author

Ferreira, Pamela C. L., primary, Therriault, Joseph, additional, Tissot, Cécile, additional, Ferrari‐Souza, João Pedro, additional, Benedet, Andréa L., additional, Povala, Guilherme, additional, Bellaver, Bruna, additional, Leffa, Douglas T., additional, Brum, Wagner S., additional, Lussier, Firoza Z., additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Vermeiren, Marie, additional, Macedo, Arthur C., additional, Cabrera, Arlec, additional, Stevenson, Jenna, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth, additional, Rahmouni, Nesrine, additional, Klunk, William E., additional, Lopez, Oscar L., additional, Villemagne, Victor L., additional, Cohen, Ann, additional, Tudorascu, Dana L., additional, Zimmer, Eduardo R., additional, Karikari, Thomas K., additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Gauthier, Serge, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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43. Amyloid beta plaque accumulation with longitudinal [18F]AZD4694 PET

Author

Therriault, Joseph, primary, Lussier, Firoza Z., additional, Tissot, Cécile, additional, Chamoun, Mira, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Kunach, Peter, additional, Wang, Yi‐Ting, additional, Fernandez‐Arias, Jaime, additional, Vermeiren, Marie, additional, Pascoal, Tharick A., additional, Massarweh, Gassan, additional, Vitali, Paolo, additional, Soucy, Jean‐Paul, additional, Saha‐Chaudhuri, Paramita, additional, Gauthie, Serge, additional, and Rosa‐Neto, Pedro, additional

Published
2023
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44. The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework

Author

Macedo, Arthur C., primary, Tissot, Cécile, additional, Therriault, Joseph, additional, Servaes, Stijn, additional, Wang, Yi-Ting, additional, Fernandez-Arias, Jaime, additional, Rahmouni, Nesrine, additional, Lussier, Firoza Z., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Vitali, Paolo, additional, Ng, Kok Pin, additional, Zimmer, Eduardo R., additional, Guiot, Marie-Christine, additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, and Rosa-Neto, Pedro, additional

Published
2023
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45. Verbal memory formation across PET-based Braak stages of tau accumulation in Alzheimer’s disease

Author

Fernández Arias, Jaime, primary, Therriault, Joseph, additional, Thomas, Emilie, additional, Lussier, Firoza Z, additional, Bezgin, Gleb, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Mathotaarachchi, Sulantha S, additional, Schoemaker, Dorothée, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Kang, Min Su, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Wang, Yi-Ting, additional, Kunach, Peter, additional, Chamoun, Mira, additional, Quispialaya S, Kely M, additional, Vitali, Paolo, additional, Massarweh, Gassan, additional, Gauthier, Serge, additional, Rajah, Maria N, additional, Pascoal, Tharick, additional, and Rosa-Neto, Pedro, additional

Published
2023
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46. Plasma and CSF concentrations of N‐terminal tau fragments associate with in vivo neurofibrillary tangle burden

Author

Lantero‐Rodriguez, Juan, primary, Tissot, Cécile, additional, Snellman, Anniina, additional, Servaes, Stijn, additional, Benedet, Andrea L., additional, Rahmouni, Nesrine, additional, Montoliu‐Gaya, Laia, additional, Therriault, Joseph, additional, Brum, Wagner S., additional, Stevenson, Jenna, additional, Lussier, Firoza Z., additional, Bezgin, Gleb, additional, Macedo, Arthur C., additional, Chamoun, Mira, additional, Mathotaarachi, Sulantha S., additional, Pascoal, Tharick A., additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Neto, Pedro Rosa, additional, and Blennow, Kaj, additional

Published
2023
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49. Medial Temporal Tau Predicts Memory Decline in Cognitively Unimpaired Elderly (P5-6.011)

Author

Kwan, Angela, primary, Arfaie, Saman, additional, Therriault, Joseph, additional, Azizi, Zahra, additional, Lussier, Firoza, additional, Tissot, Cecile, additional, Chamoun, Mira, additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Stevenon, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, and Rosa-Neto, Pedro, additional

Published
2023
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50. APOE ε4 associates with microglial activation independently of Aβ plaques and tau tangles

Author

Ferrari-Souza, João Pedro, primary, Lussier, Firoza Z., additional, Leffa, Douglas T., additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Bellaver, Bruna, additional, Ferreira, Pâmela C. L., additional, Malpetti, Maura, additional, Wang, Yi-Ting, additional, Povala, Guilherme, additional, Benedet, Andréa L., additional, Ashton, Nicholas J., additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, O’Brien, John T., additional, Rowe, James B., additional, Cohen, Ann D., additional, Lopez, Oscar L., additional, Tudorascu, Dana L., additional, Karikari, Thomas K., additional, Klunk, William E., additional, Villemagne, Victor L., additional, Soucy, Jean-Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Zimmer, Eduardo R., additional, Rosa-Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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