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3 results on '"Bezborodnyĭ SD"'

1. [Optimization of the anti-Helicobacter therapy of peptic ulcer on the basis of modern methods of pharmacokinetic analysis].

Author

Bezborodnyĭ SD

Subjects
Anti-Ulcer Agents adverse effects, Anti-Ulcer Agents pharmacokinetics, Drug Monitoring, Drug Therapy, Combination adverse effects, Drug Therapy, Combination pharmacokinetics, Female, Helicobacter Infections complications, Helicobacter Infections metabolism, Humans, Male, Omeprazole adverse effects, Omeprazole pharmacokinetics, Peptic Ulcer etiology, Peptic Ulcer metabolism, Anti-Bacterial Agents, Anti-Ulcer Agents administration & dosage, Drug Therapy, Combination administration & dosage, Helicobacter Infections drug therapy, Helicobacter pylori, Omeprazole administration & dosage, Peptic Ulcer drug therapy
Published
2000

2. [Upgrading efficiency and safety of combined antihelicobacterial treatment of ulcer patients using modern clinicopharmacological approaches].

Author

Bezborodnyĭ SD

Subjects
Adult, Anti-Bacterial Agents administration & dosage, Anti-Ulcer Agents therapeutic use, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Humans, Male, Metronidazole administration & dosage, Middle Aged, Omeprazole administration & dosage, Ranitidine administration & dosage, Treatment Outcome, Anti-Bacterial Agents therapeutic use, Helicobacter Infections drug therapy, Helicobacter Infections microbiology, Helicobacter pylori isolation & purification, Metronidazole therapeutic use, Omeprazole therapeutic use, Peptic Ulcer drug therapy, Peptic Ulcer microbiology, Ranitidine therapeutic use
Abstract

Therapeutic monitoring of ranitidine and omeprasol using automatic analyser REMEDi HS Drug Profiling System (Bio-Rad, USA) was performed in 120 patients with morphologically verified ulcer associated with Helicobacter pylori. The addition of antibacterial drugs elevated concentration of blood ranitidine, omeprasol being stable. The highest therapeutic effectiveness was achieved with combination of ranitidine plus metronidasol and jozamycin as well as omeprasol plus metronidasol and claritromycin. Ulcer patients with concomitant hepatobiliary diseases significantly more frequently developed side effects of antihelicobacterial therapy and the rise of ranitide and omeprasol concentrations in blood can serve a prognostic criterium of their appearance. As the highest tolerance was observed in the treatment with combination ranitidine + metronidasol + oletetrin, this regimen is recommended as the safest antihelicobacterial therapy.

Published
2000

3. [Josamycin combination with ranitidine in therapy of gastroduodenal ulcer: clinical efficiency].

Author

Maev IV, Vertkin AL, Vovk EI, Masharova AA, Bezborodnyĭ SD, and Lebedeva EG

Subjects
Adult, Drug Therapy, Combination, Duodenal Ulcer microbiology, Female, Helicobacter Infections drug therapy, Helicobacter Infections microbiology, Humans, Male, Stomach Ulcer microbiology, Treatment Outcome, Anti-Bacterial Agents therapeutic use, Duodenal Ulcer drug therapy, Histamine H2 Antagonists therapeutic use, Josamycin therapeutic use, Ranitidine therapeutic use, Stomach Ulcer drug therapy
Abstract

Efficacy of a novel eradication treatment with ranitidine, trichopol and jozamycin was compared to that of the standard three-component therapy and monotherapy with ranitidine in 76 patients with exacerbation of gastric and duodenal ulcer. Therapeutic monitoring of ranitidine was performed. In relation to healing of ulcer defect and eradication of Helicobacter pylori, jozamycin is not less effective and more safe than standard three-component therapy. Interaction of the scheme components increases plasma concentration of ranitidine especially in patients with concomitant hepatic and renal diseases.

Published
2000

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