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3 results on '"Beyer, Barbara D."'

1. Enantioselective synthesis of alpha-phosphono sulfonate squalene synthase inhibitors: chiral recognition in the interactions of an alpha-phosphono sulfonate inhibitor with squalene synthase

Author

Lawrence, R. Michael, Biller, Scott A., Dickson, John K., Jr., Logan, Janette V.H., Magnin, David R., Sulsky, Richard B., DiMarco, John D., Gougoutas, Jack Z., Beyer, Barbara D., Taylor, Susan C., Slusarchyk, Dorothy A., Lan, Shih-Jung, Ciosek, Carl P., Jr., Harrity, Thomas W., Jolibois, Kern G., and Kunselman, Lori K.

Subjects
Enzyme inhibitors -- Research, Enantiomers -- Research, Chemistry
Abstract

An enantioselective synthesis of the squalene synthase inhibitor, alpha-phosphono sulfonate triacid 1, was conducted. Deuterium incorporation investigations were performed first to determine the configurational stability of the chiral centers. Results indicated that both the triacid 1 and diester 2 were isolable as single enantiomers, whereas triester 3 was very sensitive to racemization. The method for the introduction of the asymmetric center was based on the sulfuration or alkylation of a chiral phosphorus carbanion.

Published
1996

2. Enantioselective Synthesis of α-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral Recognition in the Interactions of an α-Phosphono Sulfonate Inhibitor with Squalene Synthase

Author

Lawrence, R. Michael, primary, Biller, Scott A., additional, Dickson,, John K., additional, Logan, Janette V. H., additional, Magnin, David R., additional, Sulsky, Richard B., additional, DiMarco, John D., additional, Gougoutas, Jack Z., additional, Beyer, Barbara D., additional, Taylor, Susan C., additional, Lan, Shih-Jung, additional, Ciosek,, Carl P., additional, Harrity, Thomas W., additional, Jolibois, Kern G., additional, Kunselman, Lori K., additional, and Slusarchyk, Dorothy A., additional

Published
1996
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3. Aminodiol HIV Protease Inhibitors. Synthesis And Structure−Activity Relationships Of P1/P1‘ Compounds: Correlation between Lipophilicity and Cytotoxicity

Author

Chen, Ping, primary, Cheng, Peter T. W., additional, Alam, Masud, additional, Beyer, Barbara D., additional, Bisacchi, Gregory S., additional, Dejneka, Tamara, additional, Evans, Adelaide J., additional, Greytok, Jill A., additional, Hermsmeier, Mark A., additional, Humphreys, W. Griffith, additional, Jacobs, Glenn A., additional, Kocy, Octavian, additional, Lin, Pin-Fang, additional, Lis, Karen A., additional, Marella, Michael A., additional, Ryono, Denis E., additional, Sheaffer, Amy K., additional, Spergel, Steven H., additional, Sun, Chong-qing, additional, Tino, Joseph A., additional, Vite, Gregory, additional, Colonno, Richard J., additional, Zahler, Robert, additional, and Barrish, Joel C., additional

Published
1996
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