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190 results on '"Beutel, K."'

4. Clinical and immunological overlap between autoimmune lymphoproliferative syndrome and common variable immunodeficiency

Author

Rensing-Ehl, A., Warnatz, K., Fuchs, S., Schlesier, M., Salzer, U., Draeger, R., Bondzio, I., Joos, Y., Janda, A., Gomes, M., Abinun, M., Hambleton, S., Cant, A., Shackley, F., Flood, T., Waruiru, C., Beutel, K., Siepermann, K., Dueckers, G., Niehues, T., Wiesel, T., Schuster, V., Seidel, M.G., Minkov, M., Sirkiä, K., Kopp, M.V., Korhonen, M., Schwarz, K., Ehl, S., and Speckmann, C.

Published
2010
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13. Early and comprehensive vaccination coverage in paediatric recipients of related and unrelated stem cell transplantation following coadministration of the pneumoccoccal conjugate vaccine Prevenar™ and the hexavalent combination vaccine Infanrix hexa™

Author

Meisel, R., Kuypers, L., Gruhn, B., Strauss, G., Strahm, B., Ehlert, K., Beutel, K., Holter, W., Blütters-Sawatzki, R., Feuchtinger, T., Grüttner, H. P., Schubert, R., Diedrich, S., Riffelmann, M., Laws, H. J., and Dilloo, D.

Published
2008

17. Infektionen bei pädiatrisch-onkologischen Patienten

Author

Lehrnbecher, T, Berger, C, Beutel, K, Dornbusch, H J, Groll, A H, Kontny, U, Laws, H J, Simon, A, University of Zurich, DGPI - Deutsche Gesellschaft für Pädiatrische Infektiologie, Berner, Reinhard, Bialek, Ralf, Forster, Johannes, Härtel, Christoph, Heininger, Ulrich, Huppertz, Hans-Iko, Liese, Johannes G, Nadal, David, Simon, Arne, Berner, R, Bialek, R, Borte, M, et al, and Nadal, D

Subjects
10036 Medical Clinic, 610 Medicine & health
Published
2018
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21. S100A12 as diagnostic tool in the differential diagnosis of sJIA associated MAS vs. hereditary or acquired HLH

Author

Reumatologie onderzoek 2, Child Health, CTI Vastert, Infection & Immunity, Reumatologie patientenzorg, Immuno/reuma onderzoek 1 (Vastert), Holzinger, D., Fall, N., Grom, A., de Jager, W., Vastert, S., Strippoli, R., Bracaglia, C., Sundberg, E., Horne, A., Ehl, S., De Benedetti, F., Beutel, K., Foell, D., Reumatologie onderzoek 2, Child Health, CTI Vastert, Infection & Immunity, Reumatologie patientenzorg, Immuno/reuma onderzoek 1 (Vastert), Holzinger, D., Fall, N., Grom, A., de Jager, W., Vastert, S., Strippoli, R., Bracaglia, C., Sundberg, E., Horne, A., Ehl, S., De Benedetti, F., Beutel, K., and Foell, D.

Published
2015

23. Clinical presentation of Griscelli syndrome type 2 and spectrum of RAB27A mutations

Author

Meeths, M, Bryceson, YT, Rudd, E, Zheng, C, Wood, SM, Ramme, K, Beutel, K, Hasle, H, Heilmann, C, Hultenby, K, Ljunggren, HG, Fadeel, B, Nordenskjöld, M, and Henter, JI

Subjects
endocrine system
Abstract

Udgivelsesdato: 2009-Dec-1 BACKGROUND: Griscelli syndrome type 2 (GS2) is an autosomal-recessive immunodeficiency caused by mutations in RAB27A, clinically characterized by partial albinism and haemophagocytic lymphohistocytosis (HLH). We evaluated the frequency of RAB27A mutations in 21 unrelated patients with haemophagocytic syndromes without mutations in familial HLH (FHL) causing genes or an established diagnosis of GS2. In addition, we report three patients with known GS2. Moreover, neurological involvement and RAB27A mutations in previously published patients with genetically verified GS2 are reviewed. PROCEDURE: Mutation analysis of RAB27A was performed by direct DNA sequencing. NK cell activity was evaluated and microscopy of the hair was performed to confirm the diagnosis. RESULTS: RAB27A mutations were found in 1 of the 21 families. This Swedish family had three affected children with heterozygous compound mutations consisting of a novel splice error mutation, [c.239G>C], and a nonsense mutation, [c.550C>T], p.R184X. The three additional children all carried homozygous RAB27A mutations, one of which is a novel splice error mutation, [c.240-2A>C]. Of note, five of the six patients displayed neurological symptoms, while three out of six patients displayed NK cell activity within normal reference values, albeit low. A literature review revealed that 67% of GS2 patients have been reported with neurological manifestations. CONCLUSIONS: Identification of RAB27A mutations can facilitate prompt diagnosis and treatment, and aid genetic counselling and prenatal diagnosis. Since five of six patients studied herein initially were diagnosed as having FHL, we conclude that the diagnosis of GS2 may be overlooked, particularly in fair-haired patients with haemophagocytic syndromes. Pediatr Blood Cancer 2010;54:563-572. (c) 2009 Wiley-Liss, Inc.

Published
2010
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25. Infektionen bei pädiatrisch-onkologischen Patienten

Author

Berner, R, Bialek, R, Borte, M, et al, Nadal, D, Berner, R ( R ), Bialek, R ( R ), Borte, M ( M ), et al, ( ), Nadal, D ( D ), Lehrnbecher, T, Berger, C, Beutel, K, Dornbusch, H J, Groll, A H, Kontny, U, Laws, H J, Simon, A, Berner, R, Bialek, R, Borte, M, et al, Nadal, D, Berner, R ( R ), Bialek, R ( R ), Borte, M ( M ), et al, ( ), Nadal, D ( D ), Lehrnbecher, T, Berger, C, Beutel, K, Dornbusch, H J, Groll, A H, Kontny, U, Laws, H J, and Simon, A

Published
2013

26. Therapie hereditärer Thrombozytopathien

Author

Streif, W., primary, Eberl, W., primary, Andres, O., primary, Bakchoul, T., primary, Bergmann, F., primary, Beutel, K., primary, Dittmer, R., primary, Gehrisch, S., primary, Gottstein, S., primary, Halimeh, S., primary, Haselböck, J., primary, Hassenpflug, W.-A., primary, Heine, S., primary, Holzhauer, S., primary, King, S., primary, Kirchmaier, C. M., primary, Krause, M., primary, Kreuz, W., primary, Lösche, W., primary, Mahnel, R., primary, Maurer, M., primary, Nimtz-Talaska, A., primary, Olivieri, M., primary, Rott, H., primary, Schambeck, Ch. M., primary, Schedel, A., primary, Schilling, F. H., primary, Schmugge, M., primary, Schneppenheim, R., primary, Scholz, U., primary, Scholz, T., primary, Schulze, H., primary, Siegemund, A., primary, Strauß, G., primary, Sykora, K.-W., primary, Wermes, C., primary, Wiegering, V., primary, Wieland, I., primary, Zieger, B., primary, Zotz, R. B., primary, and Knöfler, R., additional

Published
2014
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28. Fatal EBV Infection and Variable Clinical Manifestations in an XLP-1 Pedigree – Rapid Diagnosis of Primary Immunodeficiencies may Save Lives

Author

Sperl, D., additional, Benesch, M., additional, Urban, C., additional, Lackner, H., additional, Sovinz, P., additional, Speicher, M., additional, Uhrig, S., additional, Schwarzbraun, T., additional, Schwinger, W., additional, zur Stadt, U., additional, Beutel, K., additional, Janka, G., additional, Scarpatetti, M., additional, and Seidel, M., additional

Published
2012
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29. Use of linezolid in neonatal and pediatric inpatient facilities—results of a retrospective multicenter survey

Author

Simon, A., primary, Müllenborn, E., additional, Prelog, M., additional, Schenk, W., additional, Holzapfel, J., additional, Ebinger, F., additional, Klabunde-Cherwon, A., additional, Faber, J., additional, Groll, A. H., additional, Masjosthusmann, K., additional, Dohna-Schwake, C., additional, Beutel, K., additional, Dirkwinkel, E., additional, Lehrnbecher, T., additional, Ammann, R. A., additional, and Müller, A., additional

Published
2011
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30. Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3

Author

Sieni, E., primary, Cetica, V., additional, Santoro, A., additional, Beutel, K., additional, Mastrodicasa, E., additional, Meeths, M., additional, Ciambotti, B., additional, Brugnolo, F., additional, zur Stadt, U., additional, Pende, D., additional, Moretta, L., additional, Griffiths, G. M., additional, Henter, J.-I., additional, Janka, G., additional, and Arico, M., additional

Published
2011
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31. Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases

Author

Rohr, J., primary, Beutel, K., additional, Maul-Pavicic, A., additional, Vraetz, T., additional, Thiel, J., additional, Warnatz, K., additional, Bondzio, I., additional, Gross-Wieltsch, U., additional, Schundeln, M., additional, Schutz, B., additional, Woessmann, W., additional, Groll, A. H., additional, Strahm, B., additional, Pagel, J., additional, Speckmann, C., additional, Janka, G., additional, Griffiths, G., additional, Schwarz, K., additional, zur Stadt, U., additional, and Ehl, S., additional

Published
2010
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43. Clinical experience of a tricomponent acellular pertussis vaccine combined with diphtheria and tetanus toxoids for primary vaccination in 22,505 infants

Author

Schmitt, H.J., Schuind, A., Knuf, M., Beutel, K., Schulte-Wissermann, H., Gahr, M., Schult, R., Folkens, J., Rauh, W., Bogaerts, H., Bork, H.L., and Clemens, R.

Abstract

OBJECTIVES: To assess the safety and tolerability of 12 lots of SmithKline Beecham Biologicals' diphtheria-tetanus-tricomponent acellular pertussis vaccine (DTaP) in a large cohort of 22,000 vaccinees, with detailed analyses of reactivity, immunogenicity, and immune response to pertussis toxin in subsets. METHODS: In a prospective, double-blind, multicenter trial in Germany, 22,505 healthy infants received three vaccinations of DTaP at age 3, 4, and 5 months. Serious adverse events were followed for 1 month after each vaccination, and neurologic events for 1 year or longer. Serum IgG antibodies were assayed before vaccination and 1 month after vaccination. RESULTS: After 67,000 doses, 153 serious adverse events (0.23%) were reported, 8 considered possibly related, and 5 related to vaccination, including 1 hypotonic-hyporesponsive episode. Incidence rates of sudden infant death syndrome (7; 0.01%) or acute neurologic events (20; 0.030%) were no higher than expected and not considered to be related to vaccination. Redness and swelling of 20 mm or greater occurred after 44 (0.6%) and 40 (0.6%) of the 7270 doses, respectively, and high fever (>39.5^o C) in 6 (0.08%) subjects within 48 hours of vaccination. In the immunogenicity analysis of 580 infants, 98% responded to pertussis toxin, 96% to filamentous hemagglutinin, and 98% to pertactin. In an additional 5712 infants, the response rate to pertussis toxin was 99%. CONCLUSIONS: In a large cohort of 22,505 infants vaccinated, SmithKline Beecham Biologicals' tricomponent DTaP vaccine was shown to be safe, well-tolerated, and immunogenic for all component antigens. (J Pediatr 1996;129:695-701)

Published
1996
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44. Reactogenicity and immunogenicity of a booster dose of a combined diphtheria, tetanus, and tricomponent acellular pertussis vaccine at fourteen to twenty-eight months of age

Author

Schmitt, H.J., Beutel, K., Schuind, A., Knuf, M., Wagner, S., Muschenborn, S., Bogaerts, H., Bock, H.L., and Clemens, R.

Abstract

Objectives: The primary objective was to assess the nature and incidence of adverse events after a fourth dose of a tricomponent acellular pertussis-diphtheria-tetanus vaccine given in the second year of life after primary vaccination with the same vaccine at 3, 4, and 5 months of age. A secondary objective was to analyze the immunogenicity of the booster vaccination. Design: Of the 5361 children enrolled (aged 14 to 28 months), adverse reactions were specifically solicited from the first 1863 enrollees for the first 4 days after vaccination and then were unsolicited for the remainder of the 4 weeks of follow-up (group 1). In the next 3498 subjects, safety and reactogenicity were entirely unsolicited for this 4-week period (group 2). Immunogenicity was analyzed by means of prebooster and postbooster serum antibody titers for all vaccine components in a random subgroup of 197 children from group 1. Results: Soliciting symptoms elicited reports of at least one symptom in 1314 of 1809 children in group 1 (72.6%), including 993 (54.9%) with local and 885 (48.9%) with general symptoms during the first 4 days after vaccination. When symptoms were gathered in an unsolicited fashion, only 580 of 3498 children in group 2 (16.6%) had a reported symptom during this time, consisting of 344 (9.8%) local and 319 (9.1%) general symptoms, respectively. An unsolicited symptom, areactive edematous swelling of the whole thigh, occurred in 62 children (1.1%), with 45 and 17 reports in groups 1 and 2, respectively. The vast majority of all reported symptoms were mild to moderate, and all children recovered without sequelae. Fourteen serious adverse events were reported, but none was considered to be related to the vaccination. Immunogenicity analysis showed a vaccine response to pertussis toxin in 99.5% of subjects, to filamentous hemagglutinin in 98.5%, and to pertactin (69 kd outer membrane protein) in 99%. All subjects had postvaccination antibody titers of 0.1 IU/ml or greater against diphtheria and tetanus toxoids. Conclusions: A fourth dose of acellular pertussis-diphtheria-tetanus vaccine as a booster dose is safe and well tolerated, although adverse events were higher than after primary vaccination. Soliciting adverse events increases the reports by a factor of 4 to 20, which suggests that the perceived clinical relevance of these events is low. The vaccine was highly immunogenic and induced a booster response. (J Pediatr 1997;130:616-23)

Published
1997
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48. IMAGES IN PAEDIATRICS: Gingivitis as probable source of a thoracic actinomycosis due to Actinomyces Israelii and Actinobacillus actinomycetemcomitans.

Author

Kordes, U, Beutel, K, Cachovan, G, Schöfer, H, Helmke, K, and Sobottka, I

Subjects
*ACTINOMYCOSIS, *GINGIVITIS, *GINGIVAL diseases, *CASE studies, *PATHOGENIC microorganisms, *PERIODONTAL disease
Abstract

The article focuses on a case study related to actinomycosis. The authors report on a 9-year-old boy who presented with a six week history of cough, weight loss, and malaise, but no fever. On physical examination he had right lower lobe dullness, and signs of gingivitis with tooth decay of the lower molars. Actinomycosis is uncommon in Europe and can be mistaken for malignancy or other granulomatous or mixed anaerobic infections. This patient probably aspirated the pathogens from his periodontal lesions.

Published
2004
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49. Considerations for Measuring Caregiver Talk in Interactions With Infants at Elevated and Population-Level Likelihood for Autism: Deriving Stable Estimates.

Author

Bottema-Beutel K, Guo R, Braun C, Dunham-Carr K, Markfeld JE, Pulliam G, Clark SM, Keçeli-Kaysılı B, Feldman JI, and Woynaroski T

Subjects
Humans, Infant, Male, Female, Autistic Disorder psychology, Siblings psychology, Caregivers psychology
Abstract

Purpose: This study aims to help researchers design observational measurement systems that yield sufficiently stable scores for estimating caregiver talk among caregivers of infant siblings of autistic and non-autistic children. Stable estimates minimize error introduced by facets of the measurement system, such as variability between coders or measurement sessions., Method: Analyses of variance were used to partition error variance between coder and session and to derive g coefficients. Decision studies determined the number of sessions and coders over which scores must be averaged to achieve sufficiently stable g coefficients (0.80). Twelve infants at elevated likelihood of an autism diagnosis and 12 infants with population-level likelihood of autism diagnosis participated in two semistructured observation sessions when the children were 12-18 months of age and again 9 months later. Caregiver follow-in talk was coded from these sessions., Results: Two sessions and one coder were needed to achieve sufficient stability for follow-in talk and follow-in comments for both groups of infants at both time points. However, follow-in directives did not reach sufficient stability for any combination of sessions or coders for the population-level likelihood group at either time point, or for the elevated likelihood group at Time 2., Conclusion: Researchers should plan to collect at least two sessions to derive sufficiently stable estimates of caregiver talk in infants at elevated and general population-level likelihood for autism., Supplemental Material: https://doi.org/10.23641/asha.27996875.

Published
2025
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50. Hablando at home: Examining the interactional resources of a bilingual autistic child.

Author

Cohen SR, Wishard Guerra A, Miguel J, Bottema-Beutel K, and Oliveira G

Subjects
Humans, Child, Preschool, Male, Multilingualism, Autistic Disorder psychology
Abstract

Daily language interactions predict child outcomes. For multilingual families who rear neurodiverse children and who may be minoritized for their language use, a dearth of research examines families' daily language interactions. Utilizing a language socialization framework and a case study methodology, 4,991 English and Spanish utterances from a 5-year old autistic child and his family were collected during naturally occurring interactions over 10 days. Utterances were analyzed for patterns of code-switching by speaker, activity setting, English or Spanish initial language, and code-switch function. Spanish was spoken in most activities. For reading, both languages were equally employed by the father. While participants used both languages across all activity settings, significant variations in code-switching type and function were observed by activity setting and speaker. We discuss implications for how home language resources can be integrated into autism interventions.

Published
2025
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