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1. Machine learning to detect the SINEs of cancer.

Author

Douville, C, Lahouel, K, Kuo, A, Grant, H, Avigdor, BE, Curtis, SD, Summers, M, Cohen, JD, Wang, Y, Mattox, A, Dudley, J, Dobbyn, L, Popoli, M, Ptak, J, Nehme, N, Silliman, N, Blair, C, Romans, K, Thoburn, C, Gizzi, J, Schoen, RE, Tie, J, Gibbs, P, Ho-Pham, LT, Tran, BNH, Tran, TS, Nguyen, TV, Goggins, M, Wolfgang, CL, Wang, T-L, Shih, I-M, Lennon, AM, Hruban, RH, Bettegowda, C, Kinzler, KW, Papadopoulos, N, Vogelstein, B, Tomasetti, C, Douville, C, Lahouel, K, Kuo, A, Grant, H, Avigdor, BE, Curtis, SD, Summers, M, Cohen, JD, Wang, Y, Mattox, A, Dudley, J, Dobbyn, L, Popoli, M, Ptak, J, Nehme, N, Silliman, N, Blair, C, Romans, K, Thoburn, C, Gizzi, J, Schoen, RE, Tie, J, Gibbs, P, Ho-Pham, LT, Tran, BNH, Tran, TS, Nguyen, TV, Goggins, M, Wolfgang, CL, Wang, T-L, Shih, I-M, Lennon, AM, Hruban, RH, Bettegowda, C, Kinzler, KW, Papadopoulos, N, Vogelstein, B, and Tomasetti, C

Abstract

We previously described an approach called RealSeqS to evaluate aneuploidy in plasma cell-free DNA through the amplification of ~350,000 repeated elements with a single primer. We hypothesized that an unbiased evaluation of the large amount of sequencing data obtained with RealSeqS might reveal other differences between plasma samples from patients with and without cancer. This hypothesis was tested through the development of a machine learning approach called Alu Profile Learning Using Sequencing (A-PLUS) and its application to 7615 samples from 5178 individuals, 2073 with solid cancer and the remainder without cancer. Samples from patients with cancer and controls were prespecified into four cohorts used for model training, analyte integration, and threshold determination, validation, and reproducibility. A-PLUS alone provided a sensitivity of 40.5% across 11 different cancer types in the validation cohort, at a specificity of 98.5%. Combining A-PLUS with aneuploidy and eight common protein biomarkers detected 51% of the cancers at 98.9% specificity. We found that part of the power of A-PLUS could be ascribed to a single feature-the global reduction of AluS subfamily elements in the circulating DNA of patients with solid cancer. We confirmed this reduction through the analysis of another independent dataset obtained with a different approach (whole-genome sequencing). The evaluation of Alu elements may therefore have the potential to enhance the performance of several methods designed for the earlier detection of cancer.

Published
2024

3. P14.11.B A MULTICENTER STUDY OF LOW-INTENSITY FOCUSED ULTRASOUND WITH SYSTEMIC MICROBUBBLE OSCILLATORS FOR BLOOD-BRAIN BARRIER DISRUPTION FOR LIQUID BIOPSY IN GLIOBLASTOMA (LIBERATE)

Author

Ahluwalia, M S, primary, DeGroot, J, additional, Lee, J, additional, Mogilner, A, additional, Schwartz, T, additional, Burns, T, additional, Shah, B, additional, McDermott, M, additional, Bettegowda, C, additional, Ozair, A, additional, Khosla, A A, additional, Sahgal, A, additional, Mishra, M, additional, Achrol, A, additional, Lipsman, N, additional, and Woodworth, G, additional

Published
2023
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4. Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules.

Author

Wang, Y, Douville, C, Cohen, JD, Mattox, A, Curtis, S, Silliman, N, Popoli, M, Ptak, J, Dobbyn, L, Nehme, N, Dudley, JC, Summers, M, Zhang, M, Ho-Pham, LT, Tran, BNH, Tran, TS, Nguyen, TV, Bettegowda, C, Papadopoulos, N, Kinzler, KW, Vogelstein, B, Wang, Y, Douville, C, Cohen, JD, Mattox, A, Curtis, S, Silliman, N, Popoli, M, Ptak, J, Dobbyn, L, Nehme, N, Dudley, JC, Summers, M, Zhang, M, Ho-Pham, LT, Tran, BNH, Tran, TS, Nguyen, TV, Bettegowda, C, Papadopoulos, N, Kinzler, KW, and Vogelstein, B

Abstract

The analysis of cell-free DNA (cfDNA) from plasma offers great promise for the earlier detection of cancer. At present, changes in DNA sequence, methylation, or copy number are the most sensitive ways to detect the presence of cancer. To further increase the sensitivity of such assays with limited amounts of sample, it would be useful to be able to evaluate the same template molecules for all these changes. Here, we report an approach, called MethylSaferSeqS, that achieves this goal, and can be applied to any standard library preparation method suitable for massively parallel sequencing. The innovative step was to copy both strands of each DNA-barcoded molecule with a primer that allows the subsequent separation of the original strands (retaining their 5-methylcytosine residues) from the copied strands (in which the 5-methylcytosine residues are replaced with unmodified cytosine residues). The epigenetic and genetic alterations present in the DNA molecules can then be obtained from the original and copied strands, respectively. We applied this approach to plasma from 265 individuals, including 198 with cancers of the pancreas, ovary, lung, and colon, and found the expected patterns of mutations, copy number alterations, and methylation. Furthermore, we could determine which original template DNA molecules were methylated and/or mutated. MethylSaferSeqS should be useful for addressing a variety of questions relating genetics and epigenetics.

Published
2023

6. O-054 Prospective study on embolization of intracranial aneurysms with the pipeline device (PREMIER study): 3-year results with the application of a specific flow-diverter occlusion classification

Author

Hanel, R, primary, Cortez, G, additional, Lopes, D, additional, Nelson, P, additional, Siddiqui, A, additional, Jabbour, P, additional, Pereira, V, additional, István, I, additional, Zaidat, O, additional, Bettegowda, C, additional, Colby, G, additional, Mokin, M, additional, Schirmer, C, additional, Hellinger, F, additional, Given, C, additional, Krings, T, additional, Taussky, P, additional, Toth, G, additional, Fraser, J, additional, Chen, M, additional, Priest, R, additional, Kan, P, additional, Fiorella, D, additional, Frei, D, additional, Aagaard-Kienitz, B, additional, Diaz, O, additional, Malek, A, additional, Cawley, C, additional, Puri, A, additional, and Kallmes, D, additional

Published
2022
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10. Patientenzufriedenheit nach Operationen und/oder Strahlentherapie bei metastasierenden Wirbelsäulenerkrankungen

Author

Versteeg, A, additional, Sahgal, A, additional, Rhines, LD, additional, Sciubba, DM, additional, Schuster, JM, additional, Weber, MH, additional, Lazary, A, additional, Boriani, S, additional, Bettegowda, C, additional, Fehlings, MG, additional, Clarke, MJ, additional, Arnold, PM, additional, Gokaslan, ZL, additional, and Fisher, CG, additional

Published
2020
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14. A Multicenter Prospective Cohort Study Evaluating Quality of Life after Radiation or Surgery for Potentially Unstable Spinal Metastases

Author

Sahgal, A., primary, Versteeg, A.L., additional, Rhines, L.D., additional, Sciubba, D.M., additional, Schuster, J.M., additional, Weber, M.H., additional, Varga, P.P., additional, Boriani, S., additional, Bettegowda, C., additional, Fehlings, M.G., additional, Clarke, M.J., additional, Arnold, P.M., additional, Gokaslan, Z.L., additional, and Fisher, C.G., additional

Published
2018
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16. P04.32 Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced de-novo mutation in survival outliers of glioblastoma

Author

Hwang, T, primary, Mathios, D, additional, McDonald, K, additional, Daris, I, additional, Park, S, additional, Burger, P, additional, Kim, S, additional, Dho, Y, additional, Hruban, C, additional, Bettegowda, C, additional, Shin, J, additional, Lim, M, additional, and Park, C, additional

Published
2018
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21. Neurology-the next 10 years

Author

Baron, Ralf, Ferriero, D M, Frisoni, G B, Bettegowda, C, Gokaslan, Z L, Kessler, J A, Vezzani, A, Waxman, S G, Jarius, S, Wildemann, B, Weller, M, and University of Zurich

Subjects
2728 Neurology (clinical), 2804 Cellular and Molecular Neuroscience, 610 Medicine & health, 10040 Clinic for Neurology
Published
2015

24. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

Author

Wang, Y., Springer, S., Zhang, M., Mcmahon, K. W., Kinde, I., Dobbyn, L., Ptak, J., Brem, H., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Groves, M. L., Jallo, G. I., Lim, M., Olivi, Alessandro, Quinones-Hinojosa, A., Rigamonti, D., Riggins, G. J., Sciubba, D. M., Weingart, J. D., Wolinsky, J. -P., Ye, X., Oba-Shinjo, S. M., Marie, S. K. N., Holdhoff, M., Agrawal, N., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Bettegowda, C., Olivi A. (ORCID:0000-0002-4489-7564), Wang, Y., Springer, S., Zhang, M., Mcmahon, K. W., Kinde, I., Dobbyn, L., Ptak, J., Brem, H., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Groves, M. L., Jallo, G. I., Lim, M., Olivi, Alessandro, Quinones-Hinojosa, A., Rigamonti, D., Riggins, G. J., Sciubba, D. M., Weingart, J. D., Wolinsky, J. -P., Ye, X., Oba-Shinjo, S. M., Marie, S. K. N., Holdhoff, M., Agrawal, N., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Bettegowda, C., and Olivi A. (ORCID:0000-0002-4489-7564)

Abstract

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-tDNA. We analyzed 35 primary CNS malignancies and found at least one mutation in each tumor using targeted or genome-wide sequencing. Using these patient-specific mutations as biomarkers, we identified detectable levels of CSF-tDNA in 74% [95% confidence interval (95% CI) = 57-88%] of cases. All medulloblastomas, ependymomas, and high-grade gliomas that abutted a CSF space were detectable (100% of 21 cases; 95% CI = 88-100%), whereas no CSF-tDNA was detected in patients whose tumors were not directly adjacent to a CSF reservoir (P < 0.0001, Fisher's exact test). These results suggest that CSF-tDNA could be useful for the management of patients with primary tumors of the brain or spinal cord.

Published
2015

26. Spinal osteoid osteoma: a multicentre retrospective cohort study comparison of results with appendicular osteoid osteoma

Author

Williams, Richard, primary, Williams, R., additional, Sowman, B., additional, Boriani, S., additional, Varga, P.P., additional, Luzzati, A., additional, Gokaslan, Z.L., additional, Fehlings, M.G., additional, Fisher, C.G., additional, Dekutoski, M.B., additional, Rhines, L.D., additional, Reynolds, J., additional, Bettegowda, C., additional, Kawahara, N., additional, and Quraishi, N.A., additional

Published
2015
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28. Reduced Lymphocytopenia Following Stereotactic Body Radiation Therapy (SBRT) for Spine Metastases Compared With Conventional Radiation Therapy (CRT)

Author

Mian, O.Y., primary, Hadelsberg, U., additional, Gokce, K., additional, Alcorn, S.R., additional, Ellsworth, S., additional, Lim, M., additional, Wolinsky, J.P., additional, Bettegowda, C., additional, Sciubba, D., additional, Gokaslan, Z., additional, Grossman, S., additional, Kleinberg, L., additional, and Redmond, K.J., additional

Published
2014
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29. TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWAL

Author

Yan, H., primary, Killela, P. J., additional, Reitman, Z. J., additional, Jiao, Y., additional, Bettegowda, C., additional, Agrawal, N., additional, Diaz, L. A., additional, Friedman, A. H., additional, Friedman, H., additional, Gallia, G. L., additional, Giovanella, B. C., additional, Grollman, A. P., additional, He, T. C., additional, He, Y., additional, Hruban, R. H., additional, Jallo, G. I., additional, Mandahl, N., additional, Meeker, A. K., additional, Mertens, F., additional, Netto, G. J., additional, Rasheed, B. A., additional, Riggins, G. J., additional, Rosenquist, T. A., additional, Schiffman, M., additional, Shih, I., additional, Theodorescu, D., additional, Torbenson, M. S., additional, Velculescu, V. E., additional, Wang, T. L., additional, Wentzensen, N., additional, Wood, L. D., additional, Zhang, M., additional, Healy, P., additional, Yang, R., additional, Diplas, B., additional, Wang, Z. H., additional, Greer, P., additional, Zhu, H. S., additional, Wang, C., additional, Carpenter, A., additional, Herndon, J. E., additional, McLendon, R. E., additional, Kinzler, K. W., additional, Vogelstein, B., additional, Papadopoulos, N., additional, and Bigner, D. D., additional

Published
2014
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31. Combined Spine Conference of the Canadian Spine Society New Zealand Orthopaedic Spine Society, Spine Society of Australia: Fairmont Château Lake Louise, Lake, Louise, Alberta, Tuesday, Feb. 25 to Saturday, Mar. 1, 20141.1.01 The use of suspension radiographs to predict LIV tilt.1.1.02 Surgical correction of adolescent idiopathic scoliosis without fusion: an animal model.1.1.03 Are full torso surface topography postural measurements more sensitive to change than back only parameters in adolescents with idiopathic scoliosis and a main thoracic curve?1.2.04 Restoration of thoracic kyphosis in adolescent idiopathic kyphosis: comparative radiographic analysis of round versus rail rods.1.2.05 Scoliosis surgery in spastic quadriplegic cerebral palsy: Is fusion to the pelvis always necessary? A 4–18-year follow-up study.1.2.06 Identification and validation of pain-related biomarkers surrounding spinal surgery in adolescents.1.3.07 Cervical sagittal deformity develops after PJK in adult throacolumbar deformity correction: radiographic analysis using a novel global sagittal angular parameter, the CTPA.1.3.08 Impact of obesity on complications and patient-reported outcomes in adult spinal deformity surgery.1.3.09 The T1 pelvic angle, a novel radiographic measure of sagittal deformity, accounts for both pelvic retroversion and truncal inclination and correlates strongly with HRQOL.1.4.10 Determining cervical sagittal deformity when it is concurrent with thoracolumbar deformity.1.4.11 The influence of sagittal balance and pelvic parameters on the outcome of surgically treated patients with degenerative spondylolisthesis.1.4.12 Predictors of degenerative spondylolisthesis and loading translation in surgical lumbar spinal stenosis patients.2.1.13 Mechanical allodynia following disc herniation requires intraneural macrophage infiltration and can be blocked by systemic selenium delivery or attenuation of BDNF activity.2.1.14 The effect of alanyl-glutamine on epidural fibrosis in a rat laminectomy model.2.1.15 Anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2: a prospective study of complications.2.2.16 2-year results of a Canadian, multicentre, blinded, pilot study of a novel peptide in promoting lumbar spine fusion.2.2.17 Comparative outcomes and cost-utility following surgical treatment of focal lumbar spinal stenosis compared with osteoarthritis of the hip or knee: long-term change in health-related quality of life.2.2.18 Changes in objectively measured walking performance, function, and pain following surgery for spondylolisthesis and lumbar spinal stenosis.2.3.19 A prospective multicentre observational data-monitored study of minimally invasive fusion to treat degenerative lumbar disorders: complications and outcomes at 1-year follow-up.2.3.20 Assessment and classification of subsidence in lateral interbody fusion using serial computed tomography.2.3.21 Predictors of willingness to undergo spinal and orthopaedic surgery after surgical consultation.2.4.22 Indirect foraminal decompression is independent of facet arthropathy in extreme lateral interbody fusion.2.4.23 Cervical artificial disc replacement with ProDisc-C: clinical and radiographic outcomes with long-term follow-up.2.4.24 Tantalum trabecular metal implants in anterior cervical corpectomy and fusion.3.1.25 Hemangiomas of the spine: results of surgical management and prognostic variables for local recurrence and mortality in a multicentre study.3.1.26 Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality in a multicentre study.3.1.27 Risk factors for recurrence of surgically treated spine schwannomas: analysis of 169 patients from a multicentre international database.3.2.28 Survival pattern and the effect of surgery on health related quality of life and functional outcome in patients with metastatic epidural spinal cord compression from lung cancer — the AOSpine North America prospective multicentre study.3.2.29 A biomechanical assessment of kyphoplasty as a stand-alone treatment in a human cadaveric burst fracture model.3.2.30 What is safer in incompetent vertebrae with posterior wall defects, kyphoplasty or vertebroplasty: a study in vertebral analogs.3.3.31 Feasibility of recruiting subjects for acute spinal cord injury (SCI) clinical trials in Canada.3.3.32 Prospective analysis of adverse events in elderly patients with traumatic spinal cord injury.3.3.33 Does traction before surgery influence time to neural decompression in patients with spinal cord injury?3.4.34 Current treatment of individuals with traumatic spinal cord injury: Do we need age-specific guidelines?3.4.35 Current surgical practice for traumatic spinal cord injury in Canada.3.4.36 The importance of “time to surgery” for traumatic spinal cord injured patients: results from an ambispective Canadian cohort of 949 patients.3.5.37 Assessment of a novel coil-shaped radiofrequency probe in the porcine spine.3.5.38 The effect of norepinephrine and dopamine on cerebrospinal fluid pressure after acute spinal cord injury.3.5.39 The learning curve of pedicle screw placement: How many screws are enough?4.1.40 Preliminary report from the Ontario Inter-professional Spine Assessment and Education Clinics (ISAEC).4.1.41 A surrogate model of the spinal cord complex for simulating bony impingement.4.1.42 Clinical and surgical predictors of specific complications following surgery for the treatment of degenerative cervical myelopathy: results from the multicentre, prospective AOSpine international study on 479 patients.4.2.43 Outcomes of surgical management of cervical spondylotic myelopathy: results of the prospective, multicentre, AOSpine international study in 479 patients.4.2.44 A clinical prediction rule for clinical outcomes in patients undergoing surgery for degenerative cervical myelopathy: analysis of an international AOSpine prospective multicentre data set of 757 subjects.4.2.45 The prevalence and impact of low back and leg pain among aging Canadians: a cross-sectional survey.4.3.46 Adjacent segment pathology: Progressive disease course or a product of iatrogenic fusion?4.3.47 Natural history of degenerative lumbar spondylolisthesis in patients with spinal stenosis.4.3.48 Changes in self-reported clinical status and health care utilization during wait time for surgical spine consultation: a prospective observational study.4.3.49 The Canadian surgical wait list for lumbar degenerative spinal stenosis has a detrimental effect on patient outcomes.4.3.50 Segmental lordosis is independent of interbody cage position in XLIF.4.3.51 Elevated patient BMI does not negatively affect self-reported outcomes of thoracolumbar surgery.1.5.52 The Spinal Stenosis Pedometer and Nutrition Lifestyle Intervention (SSPANLI): development and pilot.1.5.53 Study evaluating the variability of surgical strategy planning for patients with adult spinal deformity.1.5.54 Atlantoaxial instability in acute odontoid fractures is associated with nonunion and mortality.1.5.55 Peripheral hypersensitivity to subthreshold stimuli persists after resolution of acute experimental disc-herniation neuropathy.1.5.56 Radiation induced lumbar spinal osteonecrosis: case report and literature review.1.5.57 Comparative outcomes and cost-utility following surgical treatment of focal lumbar spinal stenosis compared with osteoarthritis of the hip or knee: Part 2 — estimated lifetime incremental cost-utility ratios.1.5.58 A predictive model of progression for adolescent idiopathic scoliosis based on 3D spine parameters at first visit.1.5.59 Development of a clinical prediction model for surgical decision making in patients with degenerative lumbar spine disease.2.5.60 Canadian spine surgery fellowship education: evaluating opportunity in developing a nationally based training curriculum.2.5.61 Pedicle subtraction osteotomy for severe proximal thoracic junctional kyphosis.2.5.62 A comparison of spine surgery referrals triaged through a multidisciplinary care pathway versus conventional referrals.2.5.63 Results and complications of posterior-based 3 column osteotomies in patients with previously fused spinal deformities.2.5.64 Orthopaedic Surgical AdVerse Event Severity (Ortho-SAVES) system: identifying opportunities for improved patient safety and resource utilization.2.5.65 Spontaneous spinal extra-axial haematomas — surgical experience in Otago and Southland 2011–2013.2.5.66 Obesity and spinal epidural lipomatosis in cauda equina syndrome.2.5.67 Factors affecting restoration of lumbar lordosis in adult degenerative scoliosis patients treated with lateral trans-psoas interbody fusion.3.6.68 Systematic review of complications in spinal surgery: a comparison of retrospective and prospective study design.3.6.69 Postsurgical rehabilitation patients have similar fear avoidance behaviour levels as those in nonoperative care.3.6.70 Outcomes of surgical treatment of adolescent spondyloptosis: a case series.3.6.71 Surgical success in primary versus revision thoracolumbar spine surgery.3.6.72 The effect of smoking on subjective patient outcomes in thoracolumbar surgery.3.6.73 Modelling patient recovery to predict outcomes following elective thoracolumbar surgery for degenerative pathologies.3.6.74 Outcomes from trans-psoas versus open approaches in the treatment of adult degenerative scoliosis.3.6.75 Lumbar spinal stenosis and presurgical assessment: the impact of walking induced strain on a performance-based outcome measure.

Author

van West, H., primary, Hodgson, B., primary, Parent, E., primary, Samuel, S., primary, Ferland, C., primary, Soroceanu, A., primary, Protopsaltis, T., primary, Radovanovic, I., primary, Amritanand, R., primary, Shamji, M., primary, Haugo, K., primary, Malham, G., primary, Jarzem, P., primary, Rampersaud, Y.R., primary, Tomkins-Lane, C., primary, Manson, N., primary, King, V., primary, Goldstein, C., primary, Fisher, C., primary, Fehlings, M., primary, Wong, E., primary, Sardar, Z., primary, Christie, S.D., primary, Patel, A., primary, Pinkoski, C., primary, Ahn, H., primary, Drew, B., primary, Dvorak, M., primary, Pezeshki, P., primary, Altaf, F., primary, Wilde, P., primary, Sparrey, C., primary, Tetreault, L., primary, Rampersaud, R., primary, Jack, A., primary, Johnstone, R., primary, Fernandes, A., primary, Urquhart, J., primary, Morokoff, A., primary, Manson, N.A., primary, Phan, P., primary, Evaniew, N., primary, Manson, J., primary, Nault, M.-L., primary, St-Pierre, G. Hardy, primary, Larouche, J., primary, Lewis, S., primary, Wilgenbusch, C., primary, Johnson, R., primary, Cushnie, D., primary, Sridharan, S., primary, Street, J., primary, Gregg, C., primary, Missiuna, P., primary, Abraham, E.P., primary, Huang, E., primary, Passmore, S., primary, Mac-Thiong, J.-M., additional, Labelle, H., additional, Moulin, D., additional, Turgeon, I., additional, Roy-Beaudry, M., additional, Bourassa, N., additional, Petit, Y., additional, Parent., S., additional, Chabot, S., additional, Westover, L., additional, Hill, D., additional, Moreau, M., additional, Hedden, D., additional, Lou, E., additional, Adeeb., S., additional, Smith, M., additional, Bridge, C., additional, Hsu, B., additional, Gray., R., additional, Group, PORSCHE Study, additional, Saran, N., additional, Stone, L., additional, Ouellet., J., additional, Protopsaltis, T., additional, Terran, J., additional, Bronsard, N., additional, Smith, J., additional, Klineberg, E., additional, Mundis, G., additional, Hostin, R., additional, Hart, R., additional, Shaffrey, C., additional, Bess, S., additional, Ames, C., additional, Schwab, F., additional, Lafage., V., additional, Lafage, V., additional, Errico., T., additional, Soroceanu, A., additional, Smith, J.S., additional, Burton, D., additional, Errico, T., additional, Kim, H. Jo, additional, Urquhart, J., additional, Gananapathy, V., additional, Siddiqi, F., additional, Gurr, K., additional, Bailey, C., additional, Ravi, B., additional, David, K., additional, Rampersaud., R., additional, Tu, Y.S., additional, Salter., M., additional, Nichol, H., additional, Fourney, D., additional, Kelly., M., additional, Parker, R., additional, Ellis, N., additional, Blecher, C., additional, Chow, F., additional, Claydon., M., additional, Sardar, Z., additional, Alexander, D., additional, Oxner, W., additional, Plessis, S. du, additional, Yee, A., additional, Wai., E., additional, Lewis, S.J., additional, Davey, J.R., additional, Gandhi, R., additional, Mahomed., N., additional, Hu, R., additional, Thomas, K., additional, Hepler, C., additional, Choi, K., additional, Rowed, K., additional, Haig., A., additional, Lam., K., additional, Seex., K., additional, Perruccio, A.V., additional, Program., UHN Arthritis, additional, Goss, B., additional, Ballok., Z., additional, Chan, P., additional, Varma., D., additional, Swart, A., additional, Winder, M., additional, Varga, P. Pal, additional, Gokaslan, Z., additional, Boriani, S., additional, Luzzati, A., additional, Rhines, L., additional, Fisher, C., additional, Chou, D., additional, Williams, R., additional, Dekutoski, M., additional, Quraishi, N., additional, Bettegowda, C., additional, Kawahara, N., additional, Fehlings., M., additional, Versteeg, A., additional, Williams, R.P., additional, Reynolds, J., additional, Fehlings, M., additional, Rhines., L., additional, Zamorano, J., additional, Nater, A., additional, Tetrault, L., additional, Varga, P., additional, Chou., D., additional, Kopjar, B., additional, Vaccaro, A., additional, Arnold, P., additional, Schuster, J., additional, Finkelstein, J., additional, France., J., additional, Whyne, C., additional, Singh, D., additional, Ford., M., additional, Aldebeyan, W., additional, Ouellet, J., additional, Steffen, T., additional, Beckman, L., additional, Weber, M., additional, Jarzem., P., additional, Kwon, B.K., additional, Ahn, H., additional, Bailey, C.S., additional, Fehlings, M.G., additional, Fourney, D.R., additional, Gagnon, D., additional, Tsai, E.C., additional, Tsui, D., additional, Parent, S., additional, Chen, J., additional, Dvorak, M., additional, Noonan, V.K., additional, Rivers, C.S., additional, Network, RHSCIR, additional, Batke, J., additional, Lenehan, B., additional, Street., J., additional, Fox, R., additional, Nataraj, A., additional, Christie, S.D., additional, Duggal, N., additional, Hurlbert, R.J., additional, Townson, A., additional, Attabib, N., additional, Network., RHSCIR, additional, Paquet, J., additional, Johnson, M.G., additional, Shen, T., additional, Drew, B., additional, Fallah, N., additional, Davidson, S., additional, McCann, C., additional, Akens, M., additional, Murphy, K., additional, Sherar, M., additional, Yee., A., additional, Belanger, L., additional, Ronco, J., additional, Dea, N., additional, Paquette, S., additional, Boyd, M., additional, Street, J., additional, Kwon, B., additional, Gonzalvo, A., additional, Fitt, G., additional, Liew, S., additional, de la Harpe, D., additional, Turner, P., additional, Rogers, M., additional, Bidos, A., additional, Fanti, C., additional, Young, B., additional, Puskas., D., additional, Tam, H., additional, Manansala, S., additional, Nosov, V., additional, Delva, M.L., additional, Alshafai, N., additional, Tan, G., additional, Ibrahim, A., additional, Tetrault., L., additional, Sundararajan, K., additional, Eng., S., additional, St-Pierre, G.H., additional, Rosas-Arellano, P., additional, Tallon, C., additional, Gurr, K.R., additional, Bailey, S.I., additional, Rosa-Arellano, P., additional, Bailey, S., additional, Bailey., C., additional, Milili, L., additional, Malham., G., additional, Green, A.J., additional, McKeon, M., additional, Abraham., E.P., additional, Lafave, L., additional, Parnell, J., additional, Rempel, J., additional, Moriartey, S., additional, Andreas, Y., additional, Wilson, P., additional, Ray, H., additional, Hu., R., additional, Ploumis, A., additional, Hess, K., additional, Wood., K., additional, Yarascavitch, B., additional, Madden, K., additional, Ghert, M., additional, Bhandari, M., additional, Kwok, D., additional, Tu, Y.-S., additional, Hadlow., A., additional, Tso, P., additional, Walker, K., additional, Mahomed, N., additional, Coyte., P.C., additional, deGuise, J., additional, Jack, A., additional, Leroux, T., additional, Broad, R., additional, Hall, H., additional, Christie, S., additional, Carey, T., additional, Mehta, V., additional, Wadey., V., additional, Dear, T., additional, Hashem., M., additional, Goldstein, S., additional, Bodrogi, A., additional, Lipkus, M., additional, Keshen, S., additional, Veillette, C., additional, Adams, D., additional, Briggs, N., additional, Lau, J., additional, Lewis, S., additional, Magtoto, R., additional, Marshall, K.W., additional, Massicotte, E., additional, Ogilvie-Harris, D., additional, Sarro, A., additional, Syed, K., additional, Mohamed., N., additional, Perera, S., additional, Taha, A., additional, Cho, R., additional, Swamy, G., additional, Power, C.L., additional, Henari, S., additional, Lenehan., B., additional, McIntosh, G., additional, Hoffman., C., additional, Karachi, A., additional, Pazionis, T., additional, AlShaya, O., additional, Manson., N.A., additional, Murray, J., additional, Suttor, S., additional, Goyal, T., additional, Littlewood, J., additional, Bains, I., additional, Bouchard, J., additional, Jacobs, B., additional, Johnson, M., additional, Pelleck, V., additional, Amad, Y., additional, Ramos, E., additional, and Glazebrook, C., additional

Published
2014
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43. Targeting Vascular and Avascular Compartments of Tumors withC. novyi-NTand Anti-microtubule Agents

Author

Dang, L.H., primary, Bettegowda, C., additional, Agrawal, N., additional, Cheong, I., additional, Huso, D., additional, Frost, P., additional, Loganzo, F., additional, Greenberger, L., additional, Barkoczy, J., additional, Pettit, G.R., additional, Smith, A.B., additional, Gurulingappa, H., additional, Khan, S., additional, Parmigiani, G., additional, Kinzler, K.W., additional, Zhou, S., additional, and Vogelstein, B., additional

Published
2004
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44. Targeting Vascular and Avascular Compartments of Tumors with C. novyi-NTand Anti-microtubule Agents

Author

Dang, L.H., Bettegowda, C., Agrawal, N., Cheong, I., Huso, D., Frost, P., Loganzo, F., Greenberger, L., Barkoczy, J., Pettit, G.R., Smith, A.B., Gurulingappa, H., Khan, S., Parmigiani, G., Kinzler, K.W., Zhou, S., and Vogelstein, B.

Abstract

Current approaches for treating cancer are limited, in part, by the inability of drugs to affect the poorly vascularized regions of tumors. We have found that C. novyi-NT in combination with anti-microtubule agents can cause the destruction of both the vascular and avascular compartments of tumors. The two classes of microtubule inhibitors were found to exert markedly different effects. Some agents that inhibited microtubule synthesis, such as HTI-286 and vinorelbine, caused rapid, massive hemorrhagic necrosis when used in combination with C. novyi-NT. In contrast, agents that stabilized microtubules, such as the taxanes docetaxel and MAC-321, resulted in slow tumor regressions that killed most neoplastic cells. Remaining cells in the poorly perfused regions of tumors could be eradicated by C. novyi-NT. Mechanistic studies showed that the microtubule destabilizers, but not the microtubule stabilizers, radically reduced blood flow to tumors, thereby enlarging the hypoxic niche in which C. novyi-NT spores could germinate. A single intravenous injection of C. novyi-NT plus selected anti-microtubule agents was able to cause regressions of several human tumor xenografts in nude mice in the absence of excessive toxicity.

Published
2004
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46. Hyper-recombination and genetic instability in BLM-deficient epithelial cells

Author

Traverso, G., Bettegowda, C., Kraus, J., Michael Speicher, Kinzler, Kw, Vogelstein, B., and Lengauer, C.

Subjects
Adenosine Triphosphatases, Recombination, Genetic, RecQ Helicases, Chromosomal Instability, DNA Helicases, Humans, Loss of Heterozygosity, Epithelial Cells, Gene Silencing, HCT116 Cells, Micronuclei, Chromosome-Defective
Abstract

Genetic instability appears to be required for a normal colorectal epithelial cell to evolve into a cancerous one. Bloom syndrome patients have a strong predisposition to cancer that affects a variety of tissues. The mechanism of disease is attributed to genomic instability, but many questions about the nature of this instability have not yet been answered. To investigate these issues, we used gene-targeting techniques to disrupt the BLM gene in karyotypically stable colorectal cancer epithelial cells. BLM knockout cells showed an increased tendency of sister chromatids to exchange DNA strands and were substantially more likely to undergo homologous recombination at chromosomal loci than parental cells. Surprisingly, BLM-deficient colorectal cancer epithelial cells did not display gross chromosomal rearrangements nor a change in the rates of chromosome gains and losses. However, the enhanced homologous recombination was associated with losses of heterozygosity. These observations define a type of genetic instability that has significant implications for the evolution of cancer.

47. Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association

Author

Caterina Giannini, Mark E. Jentoft, Aditya Raghunathan, Jacqueline A. Brosnan-Cashman, Chetan Bettegowda, Doreen N. Palsgrove, Murat Gokden, Ming Yuan, Doris D. M. Lin, Fausto J. Rodriguez, Christopher M. Heaphy, Ming Tseh Lin, Palsgrove D.N., Brosnan-Cashman J.A., Giannini C., Raghunathan A., Jentoft M., Bettegowda C., Gokden M., Lin D., Yuan M., Lin M.-T., Heaphy C.M., and Rodriguez F.J.

Subjects
Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Neurofibromatosis 1, Adolescent, Astrocytoma, Biology, Article, Neurofibromatosis, Pathology and Forensic Medicine, Brain Neoplasm, 03 medical and health sciences, FANCF, FANCG, medicine, Subependymal zone, Humans, Child, alternative lengthening of telomeres, ATRX, TSC, Retrospective Studies, RECQL4, Subependymal giant cell astrocytoma, Brain Neoplasms, subependymal giant cell astrocytoma, Middle Aged, medicine.disease, 3. Good health, Phenotype, 030104 developmental biology, Giant cell, Child, Preschool, Female, Human, Neurofibromatosis type 1
Abstract

Neurofibromatosis type-1 is a familial genetic syndrome associated with a predisposition to develop peripheral and central nervous system neoplasms. We have previously reported on a subset of gliomas developing in these patients with morphologic features resembling subependymal giant cell astrocytoma, but the molecular features of these tumors remain undefined. A total of 14 tumors were studied and all available slides were reviewed. Immunohistochemical stains and telomere-specific FISH were performed on all cases. In addition, next-generation sequencing was performed on 11 cases using a platform targeting 644 cancer-related genes. The average age at diagnosis was 28 years (range: 4–60, 9F/5M). All tumors involved the supratentorial compartment. Tumors were predominantly low grade (n = 12), with two high-grade tumors, and displayed consistent expression of glial markers. Next-generation sequencing demonstrated inactivating NF1 mutations in 10 (of 11) cases. Concurrent TSC2 and RPTOR mutations were present in two cases (1 sporadic and 1 neurofibromatosis type-1-associated). Interestingly, alternative lengthening of telomeres was present in 4 (of 14) (29%) cases. However, an ATRX mutation associated with aberrant nuclear ATRX expression was identified in only one (of four) cases with alternative lenghtening of telomeres. Gene variants in the DNA helicase RECQL4 (n = 2) and components of the Fanconi anemia complementation group (FANCD2, FANCF, FANCG) (n = 1) were identified in two alternative lenghtening of telomere-positive/ATRX-intact cases. Other variants involved genes related to NOTCH signaling, DNA maintenance/repair pathways, and epigenetic modulators. There were no mutations identified in DAXX, PTEN, PIK3C genes, TP53, H3F3A, HIST1H3B, or in canonical hotspots of IDH1, IDH2, or BRAF. A subset of subependymal giant cell astrocytoma-like astrocytomas are alternative lenghtening of telomere-positive and occur in the absence of ATRX alterations, thereby suggesting mutations in other DNA repair/maintenance genes may also facilitate alternative lenghtening of telomeres. These findings suggest that subependymal giant cell astrocytoma-like astrocytoma represents a biologically distinct group that merits further investigation.

Published
2018

48. Detection and localization of surgically resectable cancers with a multi-analyte blood test

Author

Lisa Dobbyn, Joshua T. Vogelstein, Tian Li Wang, Ammar A. Javed, Robert E. Schoen, Ralph H. Hruban, Nickolas Papadopoulos, Chetan Bettegowda, Michael Goggins, Natalie Silliman, Janine Ptak, Peter J. Allen, Bert Vogelstein, Cristian Tomasetti, Austin Mattox, Joy Schaefer, Yuxuan Wang, Kenneth W. Kinzler, Bahman Afsari, Lu Li, Christopher L. Wolfgang, Richard B.S. Roden, Anne Marie Lennon, Hui-Li Wong, J.D. Browne, Peter Gibbs, Marco Dal Molin, Jeanne Tie, Alison P. Klein, Shibin Zhou, Aaron S. Mansfield, Jin Jen, Luis A. Diaz, Randall E. Brand, Samir M. Hanash, Massimo Falconi, Christopher Douville, Ludmila Danilova, Maria Popoli, Christopher J. Thoburn, Fay Wong, Joshua D. Cohen, Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C. L., Goggins, M. G., Molin, M. D., Wang, T. -L., Roden, R., Klein, A. P., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. -L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Lennon, A. M., and Papadopoulos, N.

Subjects
0301 basic medicine, medicine.medical_specialty, Health Knowledge, Attitudes, Practice, Ovary, Gastroenterology, Polymerase Chain Reaction, Article, Circulating Tumor DNA, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Neoplasms, Medicine, Blood test, Humans, Esophagus, Lung cancer, Early Detection of Cancer, Multidisciplinary, Lung, Hematologic Tests, medicine.diagnostic_test, business.industry, Stomach, Cancer, medicine.disease, Neoplasm Proteins, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Mutation, Costs and Cost Analysis, business, Pancreas
Abstract

SEEK and you may find cancer earlier Many cancers can be cured by surgery and/or systemic therapies when detected before they have metastasized. This clinical reality, coupled with the growing appreciation that cancer's rapid genetic evolution limits its response to drugs, have fueled interest in methodologies for earlier detection of the disease. Cohen et al. developed a noninvasive blood test, called CancerSEEK that can detect eight common human cancer types (see the Perspective by Kalinich and Haber). The test assesses eight circulating protein biomarkers and tumor-specific mutations in circulating DNA. In a study of 1000 patients previously diagnosed with cancer and 850 healthy control individuals, CancerSEEK detected cancer with a sensitivity of 69 to 98% (depending on cancer type) and 99% specificity. Science , this issue p. 926 ; see also p. 866

Published
2018

49. The Management of Symptomatic Moyamoya Disease in Pediatric Patients: A Systematic Review and Meta-Analysis.

Author

Shahbandi A, Sattari SA, Azad TD, Xia Y, Lehner K, Yang W, Feghali J, Reynolds RA, Akbari SHA, Groves ML, Xu R, Caplan JM, Bettegowda C, Cohen AR, Huang J, Tamargo RJ, and Gonzalez LF

Abstract

Background and Objectives: The optimal management strategy for pediatric patients with symptomatic moyamoya disease (MMD) is not well established. This systematic review and meta-analysis compares surgical vs conservative management and direct/combined bypass (DB/CB) vs indirect bypass (IB) for pediatric patients with symptomatic MMD., Methods: MEDLINE and PubMed were searched from inception to March 17, 2024. For analysis of surgical vs conservative treatment, the primary and secondary outcomes were follow-up ischemic stroke and intracranial hemorrhagic events, respectively. For analysis of DB/CB vs IB, the primary outcome was follow-up ischemic stroke, and secondary outcomes included follow-up transient ischemic attack, new or worsened seizures, symptomatic improvement, modified Rankin Scale score ≤2, and Matsushima grade A at the last follow-up., Results: Twenty-two included studies yielded 1091 patients, with a median follow-up duration of 35.7 months. Regarding surgical vs conservative management, 428 patients were analyzed. Surgical treatment was associated with lower odds of ischemic stroke (odds ratios [OR] = 0.33 [95% CI, 0.11-0.97], P = .04), and intracranial hemorrhagic events tended to be lower with surgery (OR = 0.25 [0.06-1.03], P = .05). Regarding DB/CB techniques vs IB, 875 patients were analyzed. The groups had similar rates of ischemic stroke (OR = 0.79 [0.31-1.97], P = .61), transient ischemic attack (OR = 1.27[0.46-3.55], P = .64), new or worsened seizures (OR = 1.05[0.3-3.65], P = .93), symptomatic improvement (OR = 2.45[0.71-8.45], P = .16), and follow-up modified Rankin Scale ≤2 (OR = 1.21 [0.16-8.85], P = .85). CB was associated with higher Matsushima grade A relative to IB (OR = 3.44 [1.32-9.97], P = .01)., Conclusion: Surgical revascularization yielded more favorable clinical outcomes than conservative management in this meta-analysis. Clinical outcomes were similar between DB/CB vs IB techniques. Surgical flow augmentation, either by DB/CB or IB, seems to benefit pediatric patients with symptomatic MMD., (Copyright © Congress of Neurological Surgeons 2024. All rights reserved.)

Published
2024
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50. Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, B.C., Canada.

Author

Dionne A, Al-Zakri M, Labelle H, Joncas J, Parent S, Mac-Thiong JM, Miyanji F, Lonner B, Eren A, Cahill P, Parent S, Newton P, Dermott JA, Jaakkimainen L, To T, Bouchard M, Howard A, Lebel DE, Hardy S, Malhotra AK, Dermott J, Thevarajah D, Mathias KDA, Yoon S, Sakhrekar R, Lebel DE, Kim DJ, Hadi A, Doria A, Mitani A, Dermott J, Howard A, Lebel D, Yoon S, Mathias K, Dermott J, Lebel D, Miyanji F, Newton P, Lonner B, Bastrom T, Samdani A, Roy-Beaudry M, Beauséjour M, Imbeault R, Dufresne J, Parent S, Romeo J, Livock H, Smit K, Jarvis J, Tice A, Chan VK, Cho R, Poon S, Skaggs DL, Shumilak GK, Rocos B, Sardi JP, Charalampidis A, Gum J, Lewis SJ, Tretiakov PS, Onafowokan O, Mir J, Das A, Williamson T, Dave P, Imbo B, Lebovic J, Jankowski P, Passias PG, Lewis S, Aljamaan Y, Lenke LG, Smith J, Varshney VP, Sahjpaul R, Paquette S, Osborn J, Pelletier-Roy R, Asmussen M, Birk M, Ludwig T, Nicholls F, Zohar A, Loomans J, Pellise F, Smith JS, Kato S, Sardar Z, Lenke L, Lewis SJ, Abbas A, Toor J, Sahi G, Kovacevic D, Lex J, Miyanji F, Rampersaud R, Perruccio AV, Mahomed N, Canizares M, Rizkallah M, Lebreton MA, Boubez G, Shen J, AlShakfa F, Kamel Y, Osman G, Wang Z, Koegl N, Herrington B, Fernandes RR, Urquhart JC, Rampersaud YR, Bailey CS, Hakimjavadi R, Zhang T, DeVries Z, Wai EK, Kingwell SP, Stratton A, Tsai E, Wang Z, Phan P, Rampersaud R, Fine N, Stone L, Kapoor M, Chênevert A, Bédard S, McIntosh G, Goulet J, Couture J, Investigators C, LaRue B, Rosenstein B, Rye M, Roussac A, Naghdi N, Macedo LG, Elliott J, DeMont R, Weber MH, Pepin V, Dover G, Fortin M, Wang Z, Rizkallah M, Shen J, Lebreton MA, Florial E, AlShakfa F, Boubez G, Raj A, Amin P, McIntosh G, Rampersaud YR, AlDuwaisan AASM, Hakimjavadi R, Zhang T, Phan K, Stratton A, Tsai E, Kingwell S, Wai E, Phan P, Hebert J, Nowell S, Wedderkopp N, Vandewint A, Manson N, Abraham E, Small C, Attabib N, Bigney E, Koegl N, Craig M, Al-Shawwa A, Ost K, Tripathy S, Evaniew N, Jacobs B, Cadotte D, Malhotra AK, Evaniew N, Dea N, Investigators C, McIntosh G, Wilson JR, Evaniew N, Bailey CS, Rampersaud YR, Jacobs WB, Phan PP, Nataraj A, Cadotte DW, Weber MH, Thomas KC, Manson N, Attabib N, Paquet J, Christie SD, Wilson JR, Hall H, Fisher CG, McIntosh G, Dea N, Liu EY, Persad ARL, Baron N, Fourney D, Shakil H, Investigators C, Evaniew N, Wilson JR, Dea N, Phan P, Huang J, Fallah N, Dandurand C, Alfawaz T, Zhang T, Stratton A, Tsai E, Wai E, Kingwell S, Wang Z, Phan P, Investigators C, Zaldivar-Jolissaint JF, Charest-Morin R, McIntosh G, Fehlings MG, Pedro KM, Alvi MA, Wang JCW, Charest-Morin R, Dea N, Fisher C, Dvorak M, Kwon B, Ailon T, Paquette S, Street J, Dandurand C, Mumtaz R, Skaik K, Wai EK, Kingwell S, Stratton A, Tsai E, Phan PTN, Wang Z, Investigators C, Manoharan R, McIntosh G, Rampersaud YR, Smith-Forrester J, Douglas JE, Nemeth E, Alant J, Barry S, Glennie A, Oxner W, Weise L, Christie S, Liu EY, Persad ARL, Saeed S, Toyota P, Su J, Newton B, Coote N, Fourney D, Rachevits MS, Razmjou H, Robarts S, Yee A, Finkelstein J, Almojuela A, Zeiler F, Logsetty S, Dhaliwal P, Abdelnour M, Zhang Y, Wai E, Kingwell SP, Stratton A, Tsai E, Phan PT, Investigators C, Smith TA, Small C, Bigney E, Richardson E, Kearney J, Manson N, Abraham E, Attabib N, Bond M, Dombrowski S, Price G, García-Moreno JM, Hebert J, Qiu S, Surendran V, Cheung VSE, Ngana S, Qureshi MA, Sharma SV, Pahuta M, Guha D, Essa A, Shakil H, Malhotra A, Byrne J, Badhiwala J, Yuan E, He Y, Jack A, Mathieu F, Wilson JR, Witiw CD, Shakil H, Malhotra AK, Yuan E, Smith CW, Harrington EM, Jaffe RH, Wang AP, Ladha K, Nathens AB, Wilson JR, Witiw CD, Sandarage RV, Galuta A, Tsai EC, Rotem-Kohavi N, Dvorak MF, Xu J, Fallah N, Waheed Z, Chen M, Dea N, Evaniew N, Noonan V, Kwon B, Kwon BK, Malomo T, Charest-Morin R, Paquette S, Ailon T, Dandurand C, Street J, Fisher CG, Dea N, Heran M, Dvorak M, Jaffe R, Coyte P, Chan B, Malhotra A, Hancock-Howard R, Wilson J, Witiw C, Cho N, Squair J, Aureli V, James N, Bole-Feysot L, Dewany I, Hankov N, Baud L, Leonhartsberger A, Sveistyte K, Skinnider M, Gautier M, Galan K, Goubran M, Ravier J, Merlos F, Batti L, Pagès S, Bérard N, Intering N, Varescon C, Carda S, Bartholdi K, Hutson T, Kathe C, Hodara M, Anderson M, Draganski B, Demesmaeker R, Asboth L, Barraud Q, Bloch J, Courtine G, Christie SD, Greene R, Nadi M, Alant J, Barry S, Glennie A, Oxner B, Weise L, Julien L, Lownie C, Dvorak MF, Öner CFC, Dandurand C, Joeris A, Schnake K, Phillips M, Vaccaro AR, Bransford R, Popescu EC, El-Sharkawi M, Rajasekaran S, Benneker LM, Schroeder GD, Tee JW, France J, Paquet J, Allen R, Lavelle WF, Vialle E, Dea N, Dionne A, Magnuson D, Richard-Denis A, Petit Y, Bernard F, Barthélémy D, Mac-Thiong JM, Grassner L, Garcia-Ovejero D, Beyerer E, Mach O, Leister I, Maier D, Aigner L, Arevalo-Martin A, MacLean MA, Charles A, Georgiopoulos M, Charest-Morin R, Goodwin R, Weber M, Brouillard E, Richard-Denis A, Dionne A, Laassassy I, Khoueir P, Bourassa-Moreau É, Maurais G, Mac-Thiong JM, Zaldivar-Jolissaint JF, Dea N, Brown AA, So K, Manouchehri N, Webster M, Ethridge J, Warner A, Billingsley A, Newsome R, Bale K, Yung A, Seneviratne M, Cheng J, Wang J, Basnayake S, Streijger F, Heran M, Kozlowski P, Kwon BK, Golan JD, Elkaim LM, Alrashidi Q, Georgiopoulos M, Lasry OJ, Bednar DA, Love A, Nedaie S, Gandhi P, Amin PC, Raj A, McIntosh G, Neilsen CJ, Swamy G, Rampersaud R (On behalf of CSORN investigators), Vandewint A, Rampersaud YR, Hebert J, Bigney E, Manson N, Attabib N, Small C, Richardson E, Kearney J, Abraham E, Rampersaud R, Raj A, Marathe N, McIntosh G, Dhiman M, Bader TJ, Hart D, Swamy G, Duncan N, Dhiman M, Bader TJ, Ponjevic D, Matyas JR, Hart D, Swamy G, Duncan N, O'Brien CP, Hebert J, Bigney E, Kearney J, Richardson E, Abraham E, Manson N, Attabib N, Small C, LaRochelle L, Rivas G, Lawrence J, Ravinsky R, Kim D, Dermott J, Mitani A, Doria A, Howard A, Lebel D, Dermott JA, Switzer LS, Kim DJ, Lebel DE, Montpetit C, Vaillancourt N, Rosenstein B, Fortin M, Nadler E, Dermott J, Kim D, Lebel DE, Wolfe D, Rosenstein B, Fortin M, Wolfe D, Dover G, Boily M, Fortin M, Shakil H, Malhotra AK, Badhiwala JH, Karthikeyan V, He Y, Fehlings MG, Sahgal A, Dea N, Kiss A, Witiw CD, Redelmeier DR, Wilson JR, Caceres MP, Freire V, Shen J, Al-Shakfa F, Ahmed O, Wang Z, Kwan WC, Zuckerman SL, Fisher CG, Laufer I, Chou D, O'Toole JE, Schultheiss M, Weber MH, Sciubba DM, Pahuta M, Shin JH, Fehlings MG, Versteeg A, Goodwin ML, Boriani S, Bettegowda C, Lazary A, Gasbarrini A, Reynolds JJ, Verlaan JJ, Sahgal A, Gokaslan ZL, Rhines LD, Dea N, Truong VT, Dang TK, Osman G, Al-Shakfa F, Boule D, Shen J, Wang Z, Rizkallah M, Boubez G, Shen J, Phan P, Alshakfa F, Boule D, Belguendouz C, Kafi R, Yuh SJ, Shedid D, Wang Z, Wang Z, Shen J, Boubez G, Alshakfa F, Boulé D, Belguendouz C, Kafi R, Phan P, Shedid D, Yuh SJ, Rizkallah M, Silva YGMD, Weber L, Leão F, Essa A, Malhotra AK, Shakil H, Byrne J, Badhiwala J, Nathens AB, Azad TD, Yuan E, He Y, Jack AS, Mathieu F, Wilson JR, Witiw CD, Craig M, Guenther N, Valosek J, Bouthillier M, Enamundram NK, Rotem-Kohavi N, Humphreys S, Christie S, Fehlings M, Kwon B, Mac-Thiong JM, Phan P, Paquet J, Guay-Paquet M, Cohen-Adad J, Cadotte D, Dionne A, Mac-Thiong JM, Hong H, Kurban D, Xu J, Barthélémy D, Christie S, Fourney D, Linassi G, Sanchez AL, Paquet J, Sreenivasan V, Townson A, Tsai EC, Richard-Denis A, Kwan WC, Laghaei P, Kahlon H, Ailon T, Charest-Morin R, Dandurand C, Paquette S, Dea N, Street J, Fisher CG, Dvorak MF, Kwon BK, Thibault J, Dionne A, Al-Sofyani M, Pelletier-Roy R, Richard-Denis A, Bourassa-Moreau É, Mac-Thiong JM, Bouthillier M, Valošek J, Enamundram NK, Guay-Paquet M, Guenther N, Rotem-Kohavi N, Humphreys S, Christie S, Fehlings M, Kwon BK, Mac-Thiong JM, Phan P, Cadotte D, Cohen-Adad J, Reda L, Kennedy C, Stefaniuk S, Eftekhar P, Robinson L, Craven C, Dengler J, Kennedy C, Reda L, Stefaniuk S, Eftekhar P, Robinson L, Craven C, Dengler J, Roukerd MR, Patel M, Tsai E, Galuta A, Jagadeesan S, 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Witiw C, Harrop JS, Essa A, Lasswell T, Rasoulinejad P, Hu R, Bailey C, Siddiqi F, Hamdoon A, Soliman MA, Maraj J, Jhawar D, Jhawar B, Schuler KA, Orosz LD, Yamout T, Allen BJ, Lerebo WT, Roy RT, Schuler TC, Good CR, Haines CM, Jazini E, Ost KJ, Al-Shawwa A, Anderson D, Evaniew N, Jacobs BW, Lewkonia P, Nicholls F, Salo PT, Thomas KC, Yang M, Cadotte D, Sarraj M, Rajapaksege N, Dea N, Evaniew N, McIntosh G, Pahuta M, Alharbi HN, Skaik K, Wai EK, Kingwell S, Stratton A, Tsai E, Phan PTN, Wang Z, Investigators C, Zaldivar-Jolissaint JF, Gustafson S, Polyzois I, Gascoyne T, Goytan M, Bednar DA, Sarra M, Rocos B, Sardi JP, Charalampidis A, Gum J, Lewis SJ, Ghag R, Kirk S, Shirley O, Bone J, Morrison A, Miyanji F, Parekh A, Sanders E, Birk M, Nicholls F, Smit K, Livock H, Romeo J, Jarvis J, Tice A, Frank S, Labelle H, Parent S, Barchi S, Joncas J, Mac-Thiong JM, Thibault J, Joncas J, Barchi S, Parent S, Beausejour M, Mac-Thiong JM, Dionne A, Mac-Thiong JM, Parent S, Shen J, Joncas J, Barchi S, Labelle H, Birk MS, Nicholls F, Pelletier-Roy R, Sanders E, Lewis S, Aljamaan Y, Lenke LG, Smith J, Sardar Z, Mullaj E, Lebel D, Dermott J, Bath N, Mathias K, Kattail D, Zohar A, Loomans J, Pellise F, Smith JS, Kato S, Sardar Z, Lenke L, Lewis SJ, Bader TJ, Dhiman M, Hart D, Duncan N, Salo P, Swamy G, Lewis SJ, Lawrence PL, Smith J, Pellise F, Sardar Z, Lawrence PL, Lewis SJ, Smith J, Pellise F, Sardar Z, Levett JJ, Alnasser A, Barak U, Elkaim LM, Hoang TS, Alotaibi NM, Guha D, Moss IL, Weil AG, Weber MH, de Muelenaere P, Parvez K, Sun J, Iorio OC, Rosenstein B, Naghdi N, Fortin M, Manocchio F, Ankory R, Stallwood L, Ahn H, Mahdi H, Naeem A, Jhawar D, Moradi M, Jhawar B, Qiu S, Surendran V, Shi V, Cheung E, Ngana S, Qureshi MA, Sharma SV, Pahuta M, and Guha D

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2024
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