14 results on '"Bettale, G."'
Search Results
2. Dysarthria and cerebellar ataxia: late occurrence of severe neurotoxicity in a liver transplant recipient
- Author
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Belli, L, De Carlis, L, Romani, F, Rondinara, G, Rimoldi, P, Alberti, A, Bettale, G, Dughetti, L, Ideo, G, Sberna, M, Belli, L. S., De Carlis, L., Romani, F., Rondinara, G. F., Rimoldi, P., Alberti, A., Bettale, G., Dughetti, L., Ideo, G., SBERNA, MAURIZIO, Belli, L., Belli, L, De Carlis, L, Romani, F, Rondinara, G, Rimoldi, P, Alberti, A, Bettale, G, Dughetti, L, Ideo, G, Sberna, M, Belli, L. S., De Carlis, L., Romani, F., Rondinara, G. F., Rimoldi, P., Alberti, A., Bettale, G., Dughetti, L., Ideo, G., SBERNA, MAURIZIO, and Belli, L.
- Abstract
Neurological complications of cyclosporin (CyA) therapy are frequent, usually occurring within the 1st month after transplantation. Though leukoencephalopathy is one of them, it is rarely documented. Here we report the case of an anti-HCV-positive patient with cirrhosis who underwent liver transplantation and developed cyclosporin-induced leukoencephalopathy. The presenting symptoms were dysarthria, difficulty walking, and dysphagia. They were first noted 6 months after transplantation in association with an episode of recurrent HCV acute hepatitis. White matter abnormalities were evident on computed tomography (CT) scanning and magnetic resonance (MR) imaging. This condition improved to some degree after cyclosporin withdrawal. To our knowledge this is the second reported case of CyA neurotoxicity occurring late after liver transplantation. Moreover, the association with acute hepatitis suggests the possibility of graft dysfunction as a contributing and triggering factor. © 1993 Springer-Verlag
- Published
- 1993
3. Recurrence of HDV infection after liver transplantation
- Author
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Bettale, G, Alberti, A, Belli, L, Rondinara, G, De Carlis, L, Vai, C, Zavaglia, C, Ideo, G, Bettale, G., Alberti, A., Belli, L. S., Rondinara, G., De Carlis, L., Vai, C., Zavaglia, C., Belli, L., Ideo, G., Bettale, G, Alberti, A, Belli, L, Rondinara, G, De Carlis, L, Vai, C, Zavaglia, C, Ideo, G, Bettale, G., Alberti, A., Belli, L. S., Rondinara, G., De Carlis, L., Vai, C., Zavaglia, C., Belli, L., and Ideo, G.
- Published
- 1993
4. Factors in the development of a liver transplantation programme: Experience of 100 consecutive transplantations in Milan's Niguarda Hospital
- Author
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Bettale, G, De Carlis, L, Alberti, A, Dughetti, L, Rizzi, P, Rondinara, G, Belli, L, Del Favero, E, Ideo, G, Bettale, G., De Carlis, L., Alberti, A., Dughetti, L., Rizzi, P., Rondinara, G., Belli, L., Del Favero, E., Ideo, G., Bettale, G, De Carlis, L, Alberti, A, Dughetti, L, Rizzi, P, Rondinara, G, Belli, L, Del Favero, E, Ideo, G, Bettale, G., De Carlis, L., Alberti, A., Dughetti, L., Rizzi, P., Rondinara, G., Belli, L., Del Favero, E., and Ideo, G.
- Abstract
From December 1985 to December 1990, 100 liver orthotopic transplantations (OLTX) were performed in 89 adults with cirrhosis and various other liver diseases; eight patients had two transplants and three of these had three transplants. Organ perfusion was done with Eurocollins in the first 30, then with UW solution. Immunosuppressants were a combination of cyclosporin A and steroids for the first 30 patients, and then a combination of antilymphocyte globulin, azathioprine, methylprednisolone and cyclosporin A. The OLTXs were examined as a whole and also divided into two groups, one for 1985-88 and one for 1989-90. The cumulative survival was 63% after 12 months, 40% after 36 and 42 months. It was poor for the patients who received transplants between 1985 and 1988, but for the second group, survival was improved to 78% after 12 and 18 months. For neoplastic patients, overall survival was 49% after 18 months and 23% after 36 and 42 months. In the second group it was markedly better (83% after 18 months). The recurrence rate for patients surviving more than three months was 17% for hepatocellular carcinoma and 50% for cholangiocarcinoma. Five patients (38%) out of 13 HBsAg-positives before the transplant and surviving more than three months had recurrent hepatitis-B virus. The remaining eight patients are HBsAg negative at present. The improved actuarial survival for the second group is accounted for by the better surgical and intensive care given now and the methodological differences
- Published
- 1992
5. Experience of the first 100 liver transplantations at the Niguarda Hospital in Milan [ESPERIENZA DEI PRIMI 100 TRAPIANTI EPATICI A MILANO-NIGUARDA]
- Author
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Belli, L, De Carlis, L, Bettale, G, Del Favero, E, Rondinara, G, Ideo, G, Santandrea, E, Belli, L., De Carlis, L., Bettale, G., Del Favero, E., Rondinara, G., Ideo, G., Santandrea, E., Belli, L, De Carlis, L, Bettale, G, Del Favero, E, Rondinara, G, Ideo, G, Santandrea, E, Belli, L., De Carlis, L., Bettale, G., Del Favero, E., Rondinara, G., Ideo, G., and Santandrea, E.
- Abstract
From December 1985 to December 1990 100 orthotopic liver transplantations were performed in 89 adult patients in the Department of Transplantation, Niguarda Hospital, Milan. Techniques of donor's and recipient's operation were, with some modifications, those described by Starzl and associates. Patients were divided into two series (the first 32 OLTX and the last 68) on the basis of substantial variation occurred in operative indications, graft preservation and immunosuppression. Cumulative survival was 63% after 12 months, 46% after 36 and 42 months; in the second group it was 78% after 12 and 24 months. In neoplastic patients survival was 49% at 18 months and 23% at 36 and 42 months; in the second group, however, which included 5 occasional findings in cirrhotic patients, survival at 24 months was markedly better (83%). Out of 13 patients who were HBsAg positive before OLTX with a follow-up of more than 3 months, 10 were anti-HDV positive. Five (38%) had HBV recurrence (4 co-infection HBV-HDV), 1 with histological picture of active liver cirrhosis after 8 months. The other 8 patients did not evidence recurrence. Six patients underwent OLTX for acute fulminant hepatitis and all were negative for HGsAg and anti-HCV: 3 survived and are in good condition. Survival was markedly influenced by the preoperative status of the patients and by intraoperative blood loss. The improved survival in the second group is accounted for, in conclusion, by a better surgical/intensive care experience and methodological differences: 1. emergency operations in terminal patients are now limited; 2. selection criteria are much more restrictive; 3. actual preservation solutions allow improved graft function; 4. multidrug immunosuppression permit a better control of rejection
- Published
- 1991
6. Recurrence of HDV infection after liver transplantation
- Author
-
Bettale, G., Alberti, A., Belli, L. S., Rondinara, G., De Carlis, L., Vai, C., Zavaglia, C., Belli, L., Ideo, G., Bettale, G, Alberti, A, Belli, L, Rondinara, G, De Carlis, L, Vai, C, Zavaglia, C, and Ideo, G
- Subjects
Adult ,Liver Cirrhosis ,Male ,Hepatitis B Surface Antigens ,Medicine (all) ,Middle Aged ,Hepatitis B ,Hepatitis D ,Liver Transplantation ,Recurrence ,Humans ,Female ,Hepatitis B Vaccines ,Hepatitis Antibodies ,Hepatitis B Antibodies ,Hepatitis Delta Virus - Published
- 1993
7. Experience of the first 100 liver transplantations at the Niguarda Hospital in Milan [ESPERIENZA DEI PRIMI 100 TRAPIANTI EPATICI A MILANO-NIGUARDA]
- Author
-
Belli, L., De Carlis, L., Bettale, G., Del Favero, E., Rondinara, G., Ideo, G., Santandrea, E., Belli, L, De Carlis, L, Bettale, G, Del Favero, E, Rondinara, G, Ideo, G, and Santandrea, E
- Subjects
Surgery - Abstract
From December 1985 to December 1990 100 orthotopic liver transplantations were performed in 89 adult patients in the Department of Transplantation, Niguarda Hospital, Milan. Techniques of donor's and recipient's operation were, with some modifications, those described by Starzl and associates. Patients were divided into two series (the first 32 OLTX and the last 68) on the basis of substantial variation occurred in operative indications, graft preservation and immunosuppression. Cumulative survival was 63% after 12 months, 46% after 36 and 42 months; in the second group it was 78% after 12 and 24 months. In neoplastic patients survival was 49% at 18 months and 23% at 36 and 42 months; in the second group, however, which included 5 occasional findings in cirrhotic patients, survival at 24 months was markedly better (83%). Out of 13 patients who were HBsAg positive before OLTX with a follow-up of more than 3 months, 10 were anti-HDV positive. Five (38%) had HBV recurrence (4 co-infection HBV-HDV), 1 with histological picture of active liver cirrhosis after 8 months. The other 8 patients did not evidence recurrence. Six patients underwent OLTX for acute fulminant hepatitis and all were negative for HGsAg and anti-HCV: 3 survived and are in good condition. Survival was markedly influenced by the preoperative status of the patients and by intraoperative blood loss. The improved survival in the second group is accounted for, in conclusion, by a better surgical/intensive care experience and methodological differences: 1. emergency operations in terminal patients are now limited; 2. selection criteria are much more restrictive; 3. actual preservation solutions allow improved graft function; 4. multidrug immunosuppression permit a better control of rejection
- Published
- 1991
8. A randomized, controlled study of thymosin-alpha1 therapy in patients with anti-HBe, HBV-DNA-positive chronic hepatitis B.
- Author
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Zavaglia, C, Severini, R, Tinelli, C, Franzone, J S, Airoldi, A, Tempini, S, Bettale, G, and Ideo, G
- Abstract
No consistently effective therapy is yet available for the treatment of chronic HBsAg, anti-HBe, HBV-DNA-positive hepatitis. A multicenter trial has shown that the response rates are not significantly different when patients with anti-HBe-positive hepatitis are treated with six-month course of thymosin-alpha1 or of interferon-alpha. However, since among these patients, interferon's real efficacy is still debated, with sustained biochemical response achieved in only a few of the treated patients, we conducted this controlled study to investigate the safety and efficacy of thymosin-alpha1 as compared with no treatment. Forty-four chronic hepatitis B virus (HBV) carriers, who were anti-HBe- and HBV-DNA-positive, were randomized, with stratification for the presence of cirrhosis at baseline liver biopsy, to receive either thymosin-alpha1 at a dose of 900 microg/m2 twice a week for six months or no treatment. At entry, both groups of patients were comparable for sex, age, liver histology, ALT, IgM anti-HBc, and HBV-DNA levels. Forty-two patients were followed-up for 20 months (median; range 12-32 months) after completion of therapy: one dropped out, and one developed hepatocellular carcinoma at six months. Thymosin-alpha1 treatment had no side effects. Six months after the end of the therapy, HBV-DNA was negative and ALT had normalized in 14% of treated cases and in 4.5% of control group, while IgM anti-HBc was negative (<0.200) in 14% of the treated patients and in 4.5% of the controls. Among the treated patients, the median ALT levels stayed significantly lower compared to the pretreatment values during the treatment period and six months of follow-up. During the first year, there were six flares of hepatitis in the control group and five among the treated patients (P = NS), yielding a per year average of 0.3 and 0.23 flares per patient, respectively. Among the treated patients, median IgM anti-HBc levels were low with respect to baseline values 4-10 months after treatment started. None became HBsAg negative. In conclusion, these results indicate that, in anti-HBe, HBV-DNA-positive chronic hepatitis B, thymosin-alpha1 therapy alone does not increase the response rate, but may contribute to reduce the immune-mediated liver cell necrosis as indirectly assessed by ALT and IgM anti-HBc levels. [ABSTRACT FROM AUTHOR]
- Published
- 2000
9. Dysarthria and cerebellar ataxia: late occurrence of severe neurotoxicity in a liver transplant recipient
- Author
-
F. Romani, M. Sberna, L De Carlis, L. Dughetti, Luca S. Belli, Gianfranco Rondinara, P. Rimoldi, Gaetano Ideo, Lino Belli, G Bettale, A. AIberti, Belli, L, De Carlis, L, Romani, F, Rondinara, G, Rimoldi, P, Alberti, A, Bettale, G, Dughetti, L, Ideo, G, and Sberna, M
- Subjects
Male ,Nephrology ,medicine.medical_specialty ,Cirrhosis ,Cerebellar Ataxia ,medicine.medical_treatment ,Encephalopathy ,Liver transplantation ,Gastroenterology ,Neurotoxicity, liver transplantation, cyclosporin ,Leukoencephalopathy ,Liver transplantation, neurotoxicity, cyclosporin ,Internal medicine ,medicine ,Humans ,Transplantation ,Cerebellar ataxia ,business.industry ,Dysarthria ,Leukoencephalopathy, Progressive Multifocal ,Middle Aged ,medicine.disease ,Hepatitis C ,Magnetic Resonance Imaging ,Dysphagia ,Liver Transplantation ,Surgery ,Cyclosporine ,medicine.symptom ,business ,Cyclosporin, neurotoxicity, liver transplantation - Abstract
Neurological complications of cyclosporin (CyA) therapy are frequent, usually occurring within the 1st month after transplantation. Though leukoencephalopathy is one of them, it is rarely documented. Here we report the case of an anti-HCV-positive patient with cirrhosis who underwent liver transplantation and developed cyclosporin-induced leukoencephalopathy. The presenting symptoms were dysarthria, difficulty walking, and dysphagia. They were first noted 6 months after transplantation in association with an episode of recurrent HCV acute hepatitis. White matter abnormalities were evident on computed tomography (CT) scanning and magnetic resonance (MR) imaging. This condition improved to some degree after cyclosporin withdrawal. To our knowledge this is the second reported case of CyA neurotoxicity occurring late after liver transplantation. Moreover, the association with acute hepatitis suggests the possibility of graft dysfunction as a contributing and triggering factor. © 1993 Springer-Verlag
- Published
- 1993
10. Factors in the development of a liver transplantation programme: experience of 100 consecutive transplantations in Milan's Niguarda Hospital.
- Author
-
Bettale G, De Carlis L, Alberti A, Dughetti L, Rizzi P, Rondinara G, Belli L, Del Favero E, Belli L, and Idéo G
- Subjects
- Adult, Graft Survival drug effects, Humans, Immunosuppressive Agents administration & dosage, Italy, Liver Transplantation adverse effects, Liver Transplantation immunology, Liver Transplantation mortality, Postoperative Care, Postoperative Complications mortality, Postoperative Complications prevention & control, Prognosis, Time Factors, Transplantation Immunology drug effects, Graft Survival immunology, Liver Diseases surgery, Liver Transplantation methods, Postoperative Complications etiology, Tissue and Organ Procurement methods, Transplantation Immunology immunology
- Abstract
From December 1985 to December 1990, 100 liver orthotopic transplantations (OLTX) were performed in 89 adults with cirrhosis and various other liver diseases; eight patients had two transplants and three of these had three transplants. Organ perfusion was done with Eurocollins in the first 30, then with UW solution. Immunosuppressants were a combination of cyclosporin A and steroids for the first 30 patients, and then a combination of antilymphocyte globulin, azathioprine, methylprednisolone and cyclosporin A. The OLTXs were examined as a whole and also divided into two groups, one for 1985-88 and one for 1989-90. The cumulative survival was 63% after 12 months, 40% after 36 and 42 months. It was poor for the patients who received transplants between 1985 and 1988, but for the second group, survival was improved to 78% after 12 and 18 months. For neoplastic patients, overall survival was 49% after 18 months and 23% after 36 and 42 months. In the second group it was markedly better (83% after 18 months). The recurrence rate for patients surviving more than three months was 17% for hepatocellular carcinoma and 50% for cholangiocarcinoma. Five patients (38%) out of 13 HBsAg-positives before the transplant and surviving more than three months had recurrent hepatitis-B virus. The remaining eight patients are HBsAg negative at present. The improved actuarial survival for the second group is accounted for by the better surgical and intensive care given now and the methodological differences.
- Published
- 1992
11. Relationships between metabolic and hemostatic variables in uncomplicated diabetes.
- Author
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Vergani C, Bettale G, Mari D, and Mannucci PM
- Subjects
- Adolescent, Adult, Antigens analysis, Blood Glucose analysis, Cholesterol blood, Cholesterol, HDL, Factor VIII analysis, Factor VIII immunology, Female, Hemoglobin A analysis, Humans, Lipoproteins, HDL blood, Male, Triglycerides blood, von Willebrand Factor, Beta-Globulins analysis, Blood Coagulation Factors analysis, Diabetes Mellitus blood, Lipids blood, beta-Thromboglobulin analysis
- Abstract
Several metabolic (HbA1, HDL-C, triglycerides) and hemostatic (VIIIR: Ag, VIII:C, B-TG variables were investigated in 35 non-obese, insulin-dependent diabetics without clinically evident vascular complications. B-TG was high but did not correlate with other metabolic and hemostatic parameters, suggesting that elevated B-TG in diabetes might be an expression of in vitro platelet activation. VIIIR: Ag and the ratio of VIIIR: Ag to VIII: C were markedly increased. There was a significant correlation of the HbA1 and HDL-C levels with VIIIR: Ag, indicating that VIIIR:Ag is another reflection of metabolic control in diabetes. Additional pathogenic mechanisms, however, appear to be involved in causing the changes in VIIIR: Ag in diabetes.
- Published
- 1981
- Full Text
- View/download PDF
12. Familial hypo-alpha-lipoproteinemia.
- Author
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Vergani C and Bettale G
- Subjects
- Adult, Apolipoproteins blood, Female, Humans, Lipoproteins, HDL blood, Male, Middle Aged, Tangier Disease blood, Tangier Disease complications, Hypolipoproteinemias genetics, Tangier Disease genetics
- Abstract
A familial syndrome with hypo-alpha-lipoproteinemia is described. The affected propositus and his relatives have low levels of high density lipoprotein-cholesterol and apolipoprotein A, without any other lipid and lipoprotein abnormalities. Lipase activity and lecithin:cholesterol acyltransferase activity are also normal. A high prevalence of premature cardiac events was observed in this kindred, without any other established coronary risk factors present. The longevity analyses showed a shortening of life expectancy. The biochemical data and the pedigree are compatible with an autosomal dominant mode of inheritance.
- Published
- 1981
- Full Text
- View/download PDF
13. Role of hepatitis B virus infection in chronic liver disease of diabetic patients: a case-control study.
- Author
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Colloredo Mels G, Bettale G, Bellati G, Guanziroli M, Tiraboschi L, Angeli G, and Idéo G
- Subjects
- Adult, Chronic Disease, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 2 complications, Female, Hepatitis B Antibodies analysis, Hepatitis B Surface Antigens analysis, Humans, Male, Middle Aged, Diabetes Complications, Hepatitis B complications, Liver Diseases etiology
- Abstract
In the literature there is no agreement on the prevalence of chronic liver disease (CLD) and the role of hepatitis B virus (HBV) infection in diabetics. We undertook an epidemiological case-control study of the prevalence of CLD and HBV infection in 394 diabetics and 265 healthy subjects from Seriate and Como. The results did not show any significant differences between: 1) the prevalence of CLD in the diabetic population and in controls (4.8% vs 4.5%); 2) the prevalence of HBV infection in diabetics (HBsAg+: 8.3%; HBVAb+: 55.8%) and in controls (HBsAg+: 8.6%; HBVAb+: 54.7%); 3) the prevalence of HBV infection in diabetics with CLD (HBsAg+: 21%; HBVAb+: 52.6%) and in controls with CLD (HBsAg+: 16.6%; HBVAb+: 50%); 4) the prevalence of HBV infection in diabetics with and without CLD (HBsAg+: 21% vs 7.7%; HBVAb+: 52.6% vs 56%); 5) the prevalence of HBV infection in diabetics treated by injection and orally (HBsAg+: 6.9% vs 8.6%; HBVAb+: 58.3% vs 55.2%). The relative risk of CLD for the factor HBsAg+ was 3.2 in the diabetic population vs 1.4 in controls. In view of the presence of antidelta antibodies (HDVAb) in 25% of HBsAg+ diabetics with CLD and the lack of HBV markers in 26.3% of diabetics with CLD, we assume that other viruses (Delta, nonA-nonB) may play roles. Probably the interaction of all possible etiopathogenetic factors (alcohol, viruses, glycometabolic derangement) is determinant for CLD in diabetics.
- Published
- 1986
- Full Text
- View/download PDF
14. gamma-Glutamyl-transpeptidase in diabetics: a case control study.
- Author
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Colloredo-Mels G, Bettale G, Bellati G, Guanziroli M, Bertone V, Angeli G, and Idéo G
- Subjects
- Adult, Alcohol Drinking, Colorimetry, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Diabetes Mellitus, Type 1 enzymology, Diabetes Mellitus, Type 2 enzymology, gamma-Glutamyltransferase blood
- Abstract
Several investigators have reported high levels of gamma-glutamyl-transpeptidase (GGT) in the diabetic population. Therefore, we undertook a study to see the prevalence of 'isolated' high GGT in a large population of diabetics without chronic liver disease (CLD), as compared to an age- and sex-matched control group of non-diabetic subjects without CLD, and the role of extrahepatic factors in 'isolated' high GGT, as possible etiopathogenetic causes. We selected 351 diabetics with normal hepatologic screening, without echographic abnormalities of the hepatic parenchyma or the biliary tract. Age, duration and therapy of diabetes, body mass index (BMI), alcohol consumption, glycosylated hemoglobin (HbA1), and the presence of hepatitis B virus (HBV) were studied to see if they are related to high GGT. The control group included 260 age- and sex-matched non-diabetic subjects. We did not find any significant difference between diabetics and the control group in the prevalence of high GGT (mean: 17.5% vs. 23%; women: 16% vs. 14.5%). Multiple regression analysis showed that alcohol consumption plays the major role in the high GGT of both men and women.
- Published
- 1988
- Full Text
- View/download PDF
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