1. The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection.
- Author
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Chang, Aileen Y, Tritsch, Sarah, Reid, St Patrick, Martins, Karen, Encinales, Liliana, Pacheco, Nelly, Amdur, Richard L, Porras-Ramirez, Alexandra, Rico-Mendoza, Alejandro, Li, Guangzhao, Peng, Jin, Firestein, Gary S, Simon, Gary L, and Bethony, Jeff M
- Subjects
alphavirus ,arthritis ,chikungunya ,cytokine - Abstract
The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis.
- Published
- 2018