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We present a study of rotation across 30 square degrees of the Orion Star-forming Complex, following a $\sim$200 d photometric monitoring campaign by the Next Generation Transit Survey (NGTS). From 5749 light curves of Orion members, we report periodic signatures for 2268 objects and analyse rotation period distributions as a function of colour for 1789 stars with spectral types F0$-$M5. We select candidate members of Orion using $\textit{Gaia}$ data and assign our targets to kinematic sub-groups. We correct for interstellar extinction on a star-by-star basis and determine stellar and cluster ages using magnetic and non-magnetic stellar evolutionary models. Rotation periods generally lie in the range 1$-$10 d, with only 1.5 per cent of classical T Tauri stars or Class I/II young stellar objects rotating with periods shorter than 1.8 d, compared with 14 per cent of weak-line T Tauri stars or Class III objects. In period$-$colour space, the rotation period distribution moves towards shorter periods among low-mass (>M2) stars of age 3$-$6 Myr, compared with those at 1$-$3 Myr, with no periods longer than 10 d for stars later than M3.5. This could reflect a mass-dependence for the dispersal of circumstellar discs. Finally, we suggest that the turnover (from increasing to decreasing periods) in the period$-$colour distributions may occur at lower mass for the older-aged population: $\sim$K5 spectral type at 1$-$3 Myr shifting to $\sim$M1 at 3$-$6 Myr., This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. Published by Oxford University Press on behalf of the Royal Astronomical Society. 20 pages. 21 figures

We report the discovery of NGTS-21b, a massive hot Jupiter orbiting a low-mass star as part of the Next Generation Transit Survey (NGTS). The planet has a mass and radius of $2.36 \pm 0.21$ M$_{\rm J}$, and $1.33 \pm 0.03$ R$_{\rm J}$, and an orbital period of 1.543 days. The host is a K3V ($T_{\rm eff}=4660 \pm 41$, K) metal-poor (${\rm [Fe/H]}=-0.26 \pm 0.07$, dex) dwarf star with a mass and radius of $0.72 \pm 0.04$, M$_{\odot}$,and $0.86 \pm 0.04$, R$_{\odot}$. Its age and rotation period of $10.02^{+3.29}_{-7.30}$, Gyr and $17.88 \pm 0.08$, d respectively, are in accordance with the observed moderately low stellar activity level. When comparing NGTS-21b with currently known transiting hot Jupiters with similar equilibrium temperatures, it is found to have one of the largest measured radii despite its large mass. Inflation-free planetary structure models suggest the planet's atmosphere is inflated by $\sim21\%$, while inflationary models predict a radius consistent with observations, thus pointing to stellar irradiation as the probable origin of NGTS-21b's radius inflation. Additionally, NGTS-21b's bulk density ($1.25 \pm 0.15$, g/cm$^3$) is also amongst the largest within the population of metal-poor giant hosts ([Fe/H] < 0.0), helping to reveal a falling upper boundary in metallicity-planet density parameter space that is in concordance with core accretion formation models. The discovery of rare planetary systems such as NGTS-21 greatly contributes towards better constraints being placed on the formation and evolution mechanisms of massive planets orbiting low-mass stars., 12 pages, 13 figures, accepted for publication in MNRAS

We present the discovery and characterisation of an eclipsing binary identified by the Next Generation Transit Survey in the $\sim$115 Myr old Blanco 1 open cluster. NGTS J0002-29 comprises three M dwarfs: a short-period binary and a companion in a wider orbit. This system is the first well-characterised, low-mass eclipsing binary in Blanco 1. With a low mass ratio, a tertiary companion and binary components that straddle the fully convective boundary, it is an important benchmark system, and one of only two well-characterised, low-mass eclipsing binaries at this age. We simultaneously model light curves from NGTS, TESS, SPECULOOS and SAAO, radial velocities from VLT/UVES and Keck/HIRES, and the system's spectral energy distribution. We find that the binary components travel on circular orbits around their common centre of mass in $P_{\rm orb} = 1.09800524 \pm 0.00000038$ days, and have masses $M_{\rm pri}=0.3978\pm 0.0033$ M$_{\odot}$ and $M_{\rm sec}=0.2245\pm 0.0018$ M$_{\odot}$, radii $R_{\rm pri}=0.4037\pm 0.0048$ R$_{\odot}$ and $R_{\rm sec}=0.2759\pm 0.0055$ R$_{\odot}$, and effective temperatures $T_{\rm pri}=3372\,^{+44}_{-37}$ K and $T_{\rm sec}=3231\,^{+38}_{-31}$ K. We compare these properties to the predictions of seven stellar evolution models, which typically imply an inflated primary. The system joins a list of 19 well-characterised, low-mass, sub-Gyr, stellar-mass eclipsing binaries, which constitute some of the strongest observational tests of stellar evolution theory at low masses and young ages., 21 pages, 9 figures. Accepted for publication in MNRAS

HIP 41378 f is a temperate $9.2\pm0.1 R_{\oplus}$ planet with period of 542.08 days and an extremely low density of $0.09\pm0.02$ g cm$^{-3}$. It transits the bright star HIP 41378 (V=8.93), making it an exciting target for atmospheric characterization including transmission spectroscopy. HIP 41378 was monitored photometrically between the dates of 2019 November 19 and November 28. We detected a transit of HIP 41378 f with NGTS, just the third transit ever detected for this planet, which confirms the orbital period. This is also the first ground-based detection of a transit of HIP 41378 f. Additional ground-based photometry was also obtained and used to constrain the time of the transit. The transit was measured to occur 1.50 hours earlier than predicted. We use an analytic transit timing variation (TTV) model to show the observed TTV can be explained by interactions between HIP 41378 e and HIP 41378 f. Using our TTV model, we predict the epochs of future transits of HIP 41378 f, with derived transit centres of T$_{C,4} = 2459355.087^{+0.031}_{-0.022}$ (May 2021) and T$_{C,5} = 2459897.078^{+0.114}_{-0.060}$ (Nov 2022)., Comment: Accepted for publication in MNRAS Letters. 6 pages, 2 figures

We report the discovery of four new hot Jupiters with the Next Generation Transit Survey (NGTS). NGTS-15b, NGTS-16b, NGTS-17b, and NGTS-18b are short-period ($P, Accepted for publication in MNRAS

We are using precise radial velocities from CORALIE together with precision photometry from the Next Generation Transit Survey (NGTS) to follow up stars with single-transit events detected with the Transiting Exoplanet Survey Satellite (TESS). As part of this survey we identified a single transit on the star TIC-320687387, a bright (T=11.6) G-dwarf observed by TESS in Sector 13 and 27. From subsequent monitoring of TIC-320687387 with CORALIE, NGTS, and Lesedi we determined that the companion, TIC-320687387 B,is a very low-mass star with a mass of $96.2 \pm _{2.0}^{1.9} M_J$ and radius of $1.14 \pm _{0.02}^{0.02} R_J$ placing it close to the hydrogen burning limit ($\sim 80 M_J$). TIC-320687387 B has a wide and eccentric orbit, with a period of 29.77381 days and an eccentricity of $0.366 \pm 0.003$. Eclipsing systems such as TIC-320687387 AB allow us to test stellar evolution models for low-mass stars, which in turn are needed to calculate accurate masses and radii for exoplanets orbiting single low-mass stars. The wide orbit of TIC-320687387 B makes it particularly valuable as its evolution can be assumed to be free from perturbations caused by tidal interactions with its G-type host star., Comment: 9 pages, 6 figures, 4 tables. Submitted to MNRAS

We present the bright (V$_{mag} = 9.12$), multi-planet system TOI-431, characterised with photometry and radial velocities. We estimate the stellar rotation period to be $30.5 \pm 0.7$ days using archival photometry and radial velocities. TOI-431b is a super-Earth with a period of 0.49 days, a radius of 1.28 $\pm$ 0.04 R$_{\oplus}$, a mass of $3.07 \pm 0.35$ M$_{\oplus}$, and a density of $8.0 \pm 1.0$ g cm$^{-3}$; TOI-431d is a sub-Neptune with a period of 12.46 days, a radius of $3.29 \pm 0.09$ R$_{\oplus}$, a mass of $9.90^{+1.53}_{-1.49}$ M$_{\oplus}$, and a density of $1.36 \pm 0.25$ g cm$^{-3}$. We find a third planet, TOI-431c, in the HARPS radial velocity data, but it is not seen to transit in the TESS light curves. It has an $M \sin i$ of $2.83^{+0.41}_{-0.34}$ M$_{\oplus}$, and a period of 4.85 days. TOI-431d likely has an extended atmosphere and is one of the most well-suited TESS discoveries for atmospheric characterisation, while the super-Earth TOI-431b may be a stripped core. These planets straddle the radius gap, presenting an interesting case-study for atmospheric evolution, and TOI-431b is a prime TESS discovery for the study of rocky planet phase curves., Comment: 21 pages, 11 figures, 3 appendices, accepted for publication in MNRAS

AimsEndothelial cell (EC) dysfunction drives the initiation and pathogenesis of pulmonary arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell resolution.Methods and resultsWe carried out single-cell RNA sequencing (scRNA-seq) of lung ECs isolated from an EC lineage-tracing mouse model in Control and SU5416/hypoxia-induced PAH conditions. EC populations corresponding to distinct lung vessel types, including two discrete capillary populations, were identified in both Control and PAH mice. Differential gene expression analysis revealed global PAH-induced EC changes that were confirmed by bulk RNA-seq. This included upregulation of the major histocompatibility complex class II pathway, supporting a role for ECs in the inflammatory response in PAH. We also identified a PAH response specific to the second capillary EC population including upregulation of genes involved in cell death, cell motility, and angiogenesis. Interestingly, four genes with genetic variants associated with PAH were dysregulated in mouse ECs in PAH. To compare relevance across PAH models and species, we performed a detailed analysis of EC heterogeneity and response to PAH in rats and humans through whole-lung PAH scRNA-seq datasets, revealing that 51% of up-regulated mouse genes were also up-regulated in rat or human PAH. We identified promising new candidates to target endothelial dysfunction including CD74, the knockdown of which regulates EC proliferation and barrier integrity in vitro. Finally, with an in silico cell ordering approach, we identified zonation-dependent changes across the arteriovenous axis in mouse PAH and showed upregulation of the Serine/threonine-protein kinase Sgk1 at the junction between the macro- and microvasculature.ConclusionThis study uncovers PAH-induced EC transcriptomic changes at a high resolution, revealing novel targets for potential therapeutic candidate development.

Context: The sub-Jovian or Neptunian desert is a previously-identified region of parameter space where there is a relative dearth of intermediate-mass planets at short orbital periods. Aims: We present the discovery of a new transiting planetary system within the Neptunian desert, NGTS-14. Methods: Transits of NGTS-14Ab were discovered in photometry from the Next Generation Transit Survey (NGTS). Follow-up transit photometry was conducted from several ground-based facilities, as well as extracted from TESS full-frame images. We combine radial velocities from the HARPS spectrograph with the photometry in a global analysis to determine the system parameters. Results: NGTS-14Ab has a radius about 30 per cent larger than that of Neptune ($0.444\pm0.030~\mathrm{R_{Jup}}$), and is around 70 per cent more massive than Neptune ($0.092 \pm 0.012~\mathrm{M_{Jup}}$). It transits the main-sequence K1 star, NGTS-14A, with a period of 3.54 days, just far enough to have maintained at least some of its primordial atmosphere. We have also identified a possible long-period stellar mass companion to the system, NGTS-14B, and we investigate the binarity of exoplanet host stars inside and outside the Neptunian desert using Gaia., 11 pages, 7 figures. Accepted for publication in A&A

Leleu, A., et al., Determining the architecture of multi-planetary systems is one of the cornerstones of understanding planet formation and evolution. Resonant systems are especially important as the fragility of their orbital configuration ensures that no significant scattering or collisional event has taken place since the earliest formation phase when the parent protoplanetary disc was still present. In this context, TOI-178 has been the subject of particular attention since the first TESS observations hinted at the possible presence of a near 2:3:3 resonant chain. Here we report the results of observations from CHEOPS, ESPRESSO, NGTS, and SPECULOOS with the aim of deciphering the peculiar orbital architecture of the system. We show that TOI-178 harbours at least six planets in the super-Earth to mini-Neptune regimes, with radii ranging from 1.152to 2.87Earth radii and periods of 1.91, 3.24, 6.56, 9.96, 15.23, and 20.71 days. All planets but the innermost one form a 2:4:6:9:12 chain of Laplace resonances, and the planetary densities show important variations from planet to planet, jumping from 1.02to 0.177times the Earth's density between planets c and d. Using Bayesian interior structure retrieval models, we show that the amount of gas in the planets does not vary in a monotonous way, contrary to what one would expect from simple formation and evolution models and unlike other known systems in a chain of Laplace resonances. The brightness of TOI-178 (H = 8.76 mag, J = 9.37 mag, V = 11.95 mag) allows for a precise characterisation of its orbital architecture as well as of the physical nature of the six presently known transiting planets it harbours. The peculiar orbital configuration and the diversity in average density among the planets in the system will enable the study of interior planetary structures and atmospheric evolution, providing important clues on the formation of super-Earths and mini-Neptunes., The authors acknowledge support from the Swiss NCCR PlanetS and the Swiss National Science Foundation. Y.A. and M.J.H. acknowledge the support of the Swiss National Fund under grant 200020_172746. A.C.C. and T.W. acknowledge support from STFC consolidated grant number ST/M001296/1. This work was granted access to the HPC resources of MesoPSL financed by the Region Ile de France and the project Equip@Meso (reference ANR-10-EQPX-29-01) of the programme Investissements d’Avenir supervised by the Agence Nationale pour la Recherche. SH acknowledges CNES funding through the grant 837319. Based on data collected under the NGTS project at the ESO La Silla Paranal Observatory. The NGTS facility is operated by the consortium institutes with support from the UK Science and Technology Facilities Council (STFC) project ST/M001962/1. The Belgian participation to CHEOPS has been supported by the Belgian Federal Science Policy Office (BELSPO) in the framework of the PRODEX Program, and by the University of Liège through an ARC grant for Concerted Research Actions financed by the Wallonia-Brussels Federation. V.A. acknowledges the support from FCT through Investigador FCT contract nr. IF/00650/2015/CP1273/CT0001. We acknowledge support from the Spanish Ministry of Science and Innovation and the European Regional Development Fund through grants ESP2016-80435-C2-1-R, ESP2016-80435-C2-2-R, PGC2018-098153-B-C33, PGC2018-098153-B-C31, ESP2017-87676-C5-1-R, MDM-2017-0737 Unidad de Excelencia “María de Maeztu”- Centro de Astrobiología (INTA-CSIC), as well as the support of the Generalitat de Catalunya/CERCA programme. The MOC activities have been supported by the ESA contract No. 4000124370. S.C.C.B. acknowledges support from FCT through FCT contracts nr. IF/01312/2014/CP1215/CT0004. X.B., S.C., D.G., M.F. and J.L. acknowledge their role as ESA-appointed CHEOPS science team members. ABr was supported by the SNSA. A.C. acknowledges support by CFisUC projects (UIDB/04564/2020 and UIDP/04564/2020), GRAVITY (PTDC/FIS-AST/7002/2020), ENGAGE SKA (POCI-01-0145-FEDER-022217), and PHOBOS (POCI-01-0145-FEDER-029932), funded by COMPETE 2020 and FCT, Portugal. This work was supported by FCT - Fundaçãopara a Ciência e a Tecnologia through national funds and by FEDER through COMPETE2020 - Programa OperacionalCompetitividade e Internacionalização by these grants: UID/FIS/04434/2019; UIDB/04434/2020; UIDP/04434/2020; PTDC/FIS-AST/32113/2017 and POCI-01-0145-FEDER- 032113; PTDC/FIS-AST/28953/2017 and POCI-01-0145-FEDER-028953; PTDC/FIS-AST/28987/2017 and POCI-01-0145-FEDER-028987. O.D.S.D. is supported in the form of work contract (DL 57/2016/CP1364/CT0004) funded by national funds through FCT. B.-O.D. acknowledges support from the Swiss National Science Foundation (PP00P2-190080). M.F. and C.M.P. gratefully acknowledgethe support of the Swedish National Space Agency (DNR 65/19, 174/18). D.G. gratefully acknowledges financial support from the CRT foundation under Grant No. 2018.2323 “Gaseousor rocky? Unveiling the nature of small worlds”. E.G. gratefully acknowledges support from the David and Claudia Harding Foundation in the form of a WintonExoplanet Fellowship. M.G. is an F.R.S.-FNRS Senior Research Associate. J.I.G.H. acknowledges financial support from Spanish Ministry of Science and Innovation (MICINN) under the 2013 Ramón y Cajal programme RYC-2013-14875. J.I.G.H., A.S.M., R.R., and C.A.P. acknowledge financial support from the Spanish MICINN AYA2017-86389-P. A.S.M. acknowledges financial support from the Spanish Ministry of Science and Innovation (MICINN) under the 2019 Juan de la Cierva Programme. MNG ackowledges support from the MIT Kavli Institute as a Juan Carlos Torres Fellow. J.H. acknowledges the support of the Swiss National Fund under grant 200020_172746. KGI is the ESA CHEOPS Project Scientist and is responsible for the ESA CHEOPS Guest Observers Programme.She does not participate in, or contribute to, the definition of the Guaranteed Time Programme of the CHEOPS mission through which observations described in this paper have been taken, nor to any aspect of target selection forthe programme. J.S.J. acknowledges support by FONDECYT grant 1201371, and partial support from CONICYT project Basal AFB-170002. A.J. acknowledges support from ANID - Millennium Science Initiative - ICN12_009 and from FONDECYT project 1171208. P.M. acknowledges support from STFC research grant number ST/M001040/1. N.J.N is supported by the contract and exploratory project IF/00852/2015, and projects UID/FIS/04434/2019, PTDC/FIS-OUT/29048/2017, COMPETE2020: POCI-01-0145-FEDER-028987 & FCT: PTDC/FIS-AST/28987/2017. N.J.N is supported by the contract and exploratory project IF/00852/2015, and project PTDC/FIS-OUT/29048/2017. This work was also partially supported by a grant from the Simons Foundation (PI Queloz, grant number 327127). Acknowledges support from the Spanish Ministry of Science and Innovation and the European Regional Development Fund through grant PGC2018-098153-B- C33, as well as the support of the Generalitat de Catalunya/CERCA programme. S.G.S. acknowledges support from FCT through FCT contract nr. CEECIND/00826/2018 and POPH/FSE (EC). This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. This project has been supported by the Hungarian National Research, Development and Innovation Office (NKFIH) grants GINOP-2.3.2-15-2016-00003, K-119517, K-125015, and the City of Szombathely under Agreement No. 67.177-21/2016. This research received funding from the MERAC foundation, from the European Research Council under the European Union’s Horizon 2020 research and innovation programme (grant agreement no 803193/ BEBOP, and from the Science and Technology Facilites Council (STFC, grant no ST/S00193X/1). V.V.G. is an F.R.S-FNRS Research Associate. J.I.V. acknowledges support of CONICYT-PFCHA/Doctorado Nacional-21191829. M. R. Z. O. acknowledges financial support from projects AYA2016-79425-C3-2-P and PID2019-109522GB-C51 from the Spanish Ministry of Science, Innovation and Universities.

DW Cnc is an intermediate polar which has previously been observed in both high and low states. Observations of the high state of DW Cnc have previously revealed a spin period at ~ 38.6 min, however observations from the 2018/19 low state showed no evidence of the spin period. We present results from our analysis of 12 s cadence photometric data collected by NGTS of DW Cnc during the high state which began in 2019. Following the previously reported suppression of the spin period signal we identify the return of this signal during the high state, consistent with previous observations of it. We identify this as the restarting of accretion during the high state. We further identified three short outbursts lasting ~ 1 d in DW Cnc with a mean recurrence time of ~ 60 d and an amplitude of ~ 1 mag. These are the first outbursts identified in DW Cnc since 2008. Due to the short nature of these events we identify them not as a result of accretion instabilities but instead either from instabilities originating from the interaction of the magnetorotational instability in the accretion disc and the magnetic field generated by the white dwarf or the result of magnetic gating., Comment: Accepted to MNRAS; 8 pages, 4 figues

We report the discovery of the massive hot Jupiter NGTS-13b by the Next Generation Transit Survey (NGTS). The V = 12.7 host star is likely in the subgiant evolutionary phase with log g$_{*}$ = 4.04 $\pm$ 0.05, T$_{eff}$ = 5819 $\pm$ 73 K, M$_{*}$ = 1.30$^{+0.11}_{-0.18}$ M$_{\odot}$, and R$_{*}$ = 1.79 $\pm$ 0.06 R$_{\odot}$. NGTS detected a transiting planet with a period of P = 4.12 days around the star, which was later validated with the Transiting Exoplanet Survey Satellite (TESS; TIC 454069765). We confirm the planet using radial velocities from the CORALIE spectrograph. Using NGTS and TESS full-frame image photometry combined with CORALIE radial velocities we determine NGTS-13b to have a radius of R$_{P}$ = 1.142 $\pm$ 0.046 R$_{Jup}$, mass of M$_{P}$ = 4.84 $\pm$ 0.44 M$_{Jup}$ and eccentricity e = 0.086 $\pm$ 0.034. Some previous studies suggest that $\sim$4 M$_{Jup}$ may be a border between two separate formation scenarios (e.g., core accretion and disk instability) and that massive giant planets share similar formation mechanisms as lower-mass brown dwarfs. NGTS-13b is just above 4 M$_{Jup}$ making it an important addition to the statistical sample needed to understand the differences between various classes of substellar companions. The high metallicity, [Fe/H] = 0.25 $\pm$ 0.17, of NGTS-13 does not support previous suggestions that massive giants are found preferentially around lower metallicity host stars, but NGTS-13b does support findings that more massive and evolved hosts may have a higher occurrence of close-in massive planets than lower-mass unevolved stars., 11 pages, 9 figures, 4 tables, accepted by Astronomy & Astrophysics

We report the discovery of the transiting exoplanet NGTS-12b by the Next Generation Transit Survey (NGTS). The host star, NGTS-12, is a V=12.38 mag star with an effective temperature of T$_{\rm eff}$=$5690\pm130$ K. NGTS-12b orbits with a period of $P=7.53$d, making it the longest period planet discovered to date by the main NGTS survey. We verify the NGTS transit signal with data extracted from the TESS full-frame images, and combining the photometry with radial velocity measurements from HARPS and FEROS we determine NGTS-12b to have a mass of $0.208\pm0.022$ M$_{J}$ and a radius of $1.048\pm0.032$ R$_{J}$. NGTS-12b sits on the edge of the Neptunian desert when we take the stellar properties into account, highlighting the importance of considering both the planet and star when studying the desert. The long period of NGTS-12b combined with its low density of just $0.223\pm0.029$ g cm$^{-3}$ make it an attractive target for atmospheric characterization through transmission spectroscopy with a Transmission Spectroscopy Metric of 89.4., Comment: Accepted for publication in MNRAS, 11 pages