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3 results on '"Beteta, M. D."'

1. Diagnostic Value and Validity of Early Spondyloarthritis Features: Results From a National Spanish Cohort

Author

Joven, Beatriz E., Navarro‐Compán, Victoria, Rosas, Jose, Fernandez Dapica, Pilar, Zarco, Pedro, de Miguel, Eugenio, Collantes, E., Carmona, L., Gobbo, M., Mulero, J., de Miguel, E., Muñoz‐Fernández, S., Zarco, P., Rivera, J., López Robledillo, J. C., Castillo Gallego, C., Rosas, J., Santos, G., Fernández Sueiro, J. L., Pinto Tasende, J., González Díaz de Rabago, E., Montilla, C., Gómez Castro, S., López, R., del Pino Montes, J., Granados Bautista, I. P., Hernández Sanz, A., Sanz Sanz, J., Fernández Prada, M., Tornero, J., Campos, C., Calvo, J., Juanola, X., Ríos, V., Moreno, E., Rotés, M. I., Ibero, I., Fernández Carballido, C., Jovaní, V., Martínez Alberola, N., Linares, L. F., Moreno Ramos, M. J., Uceda, A., Moreno Martínez, M. J., Beteta, M. D., Quevedo, J. C., Rodríguez Lozano, C., Trujillo, E., Bustabad, S., A/Román Ivorra, J., Muñoz Gil, S., Juan Mas, A., Ros Vilamajó, I., Ibáñez Barceló, M., Son Llatzer, H., Castro Villegas, M. C., Gratacós Matmija, J., Moreno Martínez‐Loza, M., Almodóvar, R., Rejón, E., Rodríguez Montero, S., Ruiz Jimeno, T., Aznar, J. J., Chamizo Carmona, E., Garrido Puñal, N., Fernández Dapica, P., Brito Brito, E., and Pérez Pampín, E.

Abstract

To evaluate the validity of different spondyloarthritis (SpA) features included in the Berlin diagnostic algorithm and the Assessment of SpondyloArthritis international Society (ASAS) classification criteria in an early SpA cohort. This was a longitudinal multicenter study including patients from the ESPeranza program cohort who were suspected to have SpA. Subjects were ≤45 years old, and SpA symptom duration was 3–24 months. Patients with axial SpA symptoms were selected and categorized according to diagnosis (yes/no) of axial SpA. Descriptive analysis was performed, and the sensitivity, specificity, predictive value, and likelihood ratio (LR) of each feature were calculated. Of 775 patients suspected to have SpA, 665 had predominantly axial symptoms and 516 of these patients were diagnosed with axial SpA. The most useful SpA features were sacroiliitis on magnetic resonance imaging (positive LR 6.6) or radiograph (positive LR 31.1) and peripheral arthritis (positive LR 8.9). The features with the lowest diagnostic utility were a family history of SpA (positive LR 1.5) and good response to nonsteroidal antiinflammatory drugs (positive LR 1.6). Inflammatory back pain (IBP; according to ASAS criteria) was described in only 27% of SpA patients, with a positive LR of 2.3. HLA–B27 positivity was present in 245 (48%), and the positive LR was 2.8. The diagnostic value of SpA features in patients with early axial SpA seems to be different than in patients with longstanding disease. Chronic back pain is better than IBP as an entry point to the diagnostic algorithm. Sacroiliitis on imaging is very important for early diagnosis, while the use of HLA–B27 status as a key factor is questionable.

Published
2017
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2. Disease Activity As a Major Determinant of Quality of Life and Physical Function in Patients With Early Axial Spondyloarthritis

Author

Fernández‐Carballido, Cristina, Navarro‐Compán, Victoria, Castillo‐Gallego, Concepción, Castro‐Villegas, Maria C., Collantes‐Estévez, Eduardo, de Miguel, Eugenio, Collantes, E., Reina Sofía, H., Carmona, L., Gobbo, M., Mulero, J., Puerta de Hierro, H., Muñoz‐Fernández, S., Infanta Sofía, H., Zarco, P., Alcorcón, F. H., Rivera, J., Gregorio Marañón, H., López Robledillo, J. C., Niño Jesús, H., Castillo Gallego, C., La Paz, H. U., Rosas, J., Santos, G., Marina Baixa, H., Fernández Sueiro, J. L., Pinto Tasende, J., González Díaz de Rabago, E., Juanv, H. U., Montilla, C., Gómez Castro López, S., del Pino Montes, R. J., de Salamanca, H. U., Granados Bautista, I. P., Hernández Sanz, A., Virgen de la Salud, H., Sanz Sanz, J., Puerta de Hierro, H., Fernández Prada, M., Tornero, J., de Guadalajara, H. U., Campos, C., Calvo, J., de Valencia, H. G. U., Juanola, X., Ríos, V., de Bellvitge, H. U., Moreno, E., Rotés, M. I., de San Rafael, H., Ibero, I., Jovaní, V., Martínez Alberola, N., de Elda, H. G. U., Linares, L. F., Moreno Ramos, M. J., Uceda, A., Moreno Martínez, M. J., Beteta, M. D., Virgen de la Arrixaca, H. U., Quevedo, J. C., Rodríguez Lozano, C., Negrín, H. U., Trujillo, E., Bustabad, S., de Canarias, H. U., Román Ivorra, J. A., Muñoz Gil, S., Peset, H. U., Juan Mas, A., Ros Vilamajó, I., Ibáñez Barceló, M., Son Llatzer, H., Gratacós Matmija, J., Moreno Martínez‐Loza, M., Sabadell, H., Almodóvar, R., Fundación Alcorcón, H., Rejón, E., Rodríguez Montero, S., Virgen de Valme, H. U., Ruiz Jimeno, T., Sierrallana, H., Aznar, J. J., Chamizo Carmona, E., Garrido Puñal, N., de Mérida, H., Fernández Dapica, P., Brito Brito, E., Ramón y Cajal, H., Pérez Pampín, E., and Clínico, H.

Abstract

To describe health‐related quality of life (HRQOL) and physical function in patients with early axial spondyloarthritis (SpA) and to assess their associations with disease activity and radiographic damage. This was a cross‐sectional study drawing upon baseline data of axial SpA patients (Assessment of SpondyloArthritis international Society criteria) from the ESPERANZA cohort. Linear regression analyses were used to evaluate the associations between disease activity and radiographic damage (spine and sacroiliac joints) with HRQOL, physical function, and spinal mobility. In total, 259 patients were included. The mean ± SD age was 32.2 ± 6.9 years, disease duration was 13.3 ± 6.8 months, Ankylosing Spondylitis Quality of Life score was 5.9 ± 4.8, Bath Ankylosing Spondylitis Functional Index score was 2.4 ± 2.3, Bath Ankylosing Spondylitis Metrology Index score was 1.4 ± 1.3, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was 3.8 ± 2.3, C‐reactive protein (CRP) level was 9.7 ± 13.2 mg/liter, and Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI‐s) score was 1.7 ± 1.6. HRQOL was mainly associated with disease activity on univariate analysis (β values for BASDAI 0.646, patient global visual analog scale [VAS] 0.641, night back pain VAS 0.598, physician VAS 0.560, and CRP level 0.275; P< 0.01 for all), whereas the association with radiographic damage was weaker (standardized β for BASRI‐s 0.142; P< 0.05). On multivariate models, HRQOL only remained significantly associated with disease activity (standardized β for BASDAI 0.330; P< 0.01, and physician VAS 0.205 and night back pain VAS 0.210; P= 0.01). Similarly, physical function was associated with disease activity and radiographic damage on univariate analysis, but only with disease activity (BASDAI β 0.466; P< 0.01) on multivariate analysis. However, spinal mobility was associated with radiographic damage in both univariate and multivariate analyses. Patients with axial SpA already have impaired quality of life and physical function, albeit mildly, at the beginning of their disease course. Both outcomes are mainly associated with disease activity in these patients.

Published
2017
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3. Differences between familial and sporadic early spondyloarthritis: Results from the ESPERANZA cohort

Author

Almodóvar, R., Navarro-Compán, V., Fernández-Carballido, C., Hernández, A., Miguel, E., Zarco, P., Collantes, E., Carmona, L., Gobbo, M., Mulero, J., Muñoz-Fernández, S., Infanta Sofía, H., Rivera, J., López Robledillo, J. C., Castillo Gallego, C., Rosas, J., Santos, G., Fernández Sueiro, J. L., Pinto Tasende, J., González Díaz Rabago, E., Montilla, C., Gómez Castro, S., López, R., Del Pino Montes, J., Granados Bautista, I. P., Hernández Sanz, A., Sanz Sanz, J., Fernández Prada, M., Tornero, J., Campos, C., Calvo, J., Juanola, X., Ríos, V., Moreno, E., Rotés, M. I., Ibero, I., Jovaní, V., Martínez Alberola, N., Linares, L. F., Moreno Ramos, M. J., Uceda, A., Moreno Martínez, M. J., Beteta, M. D., Quevedo, J. C., Rodríguez Lozano, C., Trujillo, E., Bustabad, S., Román Ivorra, J. A., Muñoz Gil, S., Juan Mas, A., Ros Vilamajó, I., Ibáñez Barceló, M., Castro Villegas, M. C., Gratacós Matmija, J., Moreno Martínez-Loza, M., Rejón, E., Rodríguez Montero, S., Ruiz Jimeno, T., Aznar, J. J., Chamizo Carmona, E., Garrido Puñal, N., Fernández Dapica, P., Brito Brito, E., and Pérez Pampín, E.

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