1. [Protein markers in evaluation of nephroprotective effects of antihypertensive drugs in patients with arterial hypertension].
- Author
-
Rakov SS and Betekhtina VA
- Subjects
- Adult, Aged, Albuminuria diagnosis, Antihypertensive Agents therapeutic use, Atenolol pharmacology, Atenolol therapeutic use, Biomarkers, Female, Haptoglobins urine, Humans, Immunoglobulins urine, Isradipine pharmacology, Isradipine therapeutic use, Male, Middle Aged, Models, Theoretical, Monitoring, Physiologic, Prealbumin urine, Ramipril pharmacology, Ramipril therapeutic use, Transferrin urine, Antihypertensive Agents pharmacology, Apolipoproteins urine, Complement C3 urine, Complement C4 urine, Hypertension drug therapy, Immunoglobulin G urine, Kidney drug effects, Proteinuria diagnosis
- Abstract
Fifty patients with stable slight and moderate uncomplicated essential hypertension, treated by ramipril, atenolol, or isradipine, were examined. Total protein and urinary excretion of individual proteins were studied before and after treatment. Urinary concentrations of apolipoproteins A1 and B1, alpha 1-acid glycoprotein, alpha 1-antitrypsin, prealbumin, albumin, beta 2-microglobulin, transferrin, haptoglobin, IgG and IgA, and C3 and C4 complement components were measured. Index of proteinuria selectiveness was calculated for each portion of urine. All three drugs exerted a nephroprotective effect, atenolol being the most active of them. Apolipoproteins, IgG, and complement components were the most valuable for diagnosis. Their excretion correlated with the severity of arterial hypertension and efficiency of treatment. Use of protein markers helps reliably assess the renal function and monitor the treatment efficiency.
- Published
- 2000