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1. End-to-end SYNTAX score prediction: benchmark and methods

Author

Ponomarchuk, Alexander, Kruzhilov, Ivan, Zubkova, Galina, Shadrin, Artem, Utegenov, Ruslan, Bessonov, Ivan, and Blinov, Pavel

Subjects
Computer Science - Computer Vision and Pattern Recognition, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

The SYNTAX score has become a widely used measure of coronary disease severity , crucial in selecting the optimal mode of revascularization. This paper introduces a new medical regression and classification problem - automatically estimating SYNTAX score from coronary angiography. Our study presents a comprehensive dataset of 1,844 patients, featuring a balanced distribution of individuals with zero and non-zero scores. This dataset includes a first-of-its-kind, complete coronary angiography samples captured through a multi-view X-ray video, allowing one to observe coronary arteries from multiple perspectives. Furthermore, we present a novel, fully automatic end-to-end method for estimating the SYNTAX. For such a difficult task, we have achieved a solid coefficient of determination R2 of 0.51 in score predictions.

Published
2024

3. Neural network-based coronary dominance classification of RCA angiograms

Author

Kruzhilov, Ivan, Ikryannikov, Egor, Shadrin, Artem, Utegenov, Ruslan, Zubkova, Galina, and Bessonov, Ivan

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Background. Cardiac dominance classification is essential for SYNTAX score estimation, which is a tool used to determine the complexity of coronary artery disease and guide patient selection toward optimal revascularization strategy. Objectives. Cardiac dominance classification algorithm based on the analysis of right coronary artery (RCA) angiograms using neural network Method. We employed convolutional neural network ConvNext and Swin transformer for 2D image (frames) classification, along with a majority vote for cardio angiographic view classification. An auxiliary network was also used to detect irrelevant images which were then excluded from the data set. Our data set consisted of 828 angiographic studies, 192 of them being patients with left dominance. Results. 5-fold cross validation gave the following dominance classification metrics (p=95%): macro recall=93.1%, accuracy=93.5%, macro F1=89.2%. The most common case in which the model regularly failed was RCA occlusion, as it requires utilization of LCA information. Another cause for false prediction is a small diameter combined with poor quality cardio angiographic view. In such cases, cardiac dominance classification can be complex and may require discussion among specialists to reach an accurate conclusion. Conclusion. The use of machine learning approaches to classify cardiac dominance based on RCA alone has been shown to be successful with satisfactory accuracy. However, for higher accuracy, it is necessary to utilize LCA information in the case of an occluded RCA and detect cases where there is high uncertainty.

Published
2023

4. Type D personality as a risk factor for adverse outcome in patients with cardiovascular disease: an individual patient data meta-analysis

Author

Lodder, Paul, Wicherts, Jelte M., Antens, Marijn, Albus, Christian, Bessonov, Ivan S., Condén, Emelie, Dulfer, Karolijn, Gostoli, Sara, Grande, Gesine, Hedberg, Pär, Herrmann-Lingen, Christoph, Jaarsma, Tiny, Koo, Malcolm, Lin, Ping, Lin, Tin-Kwang, Meyer, Thomas, Pushkarev, Georgiy, Rafanelli, Chiara, Raykh, Olga I., de Quadros, Alexandre Schaan, Schmidt, Marcia, Sumin, Alexei N., Utens, Elisabeth M.W.J., van Veldhuisen, Dirk J., Wang, Yini, and Kupper, Nina

Published
2023
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5. Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry

Author

De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Okkels Jensen, Lisette, Loh, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang-yin, Arifa Juzar, Dafsah, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João A., Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopoulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, and Verdoia, Monica

Published
2022
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6. Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic

Author

De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, LOH, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Lung, Aaron Wong Sung, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang-yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Mert, Kadir Ugur, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, and Verdoia, Monica

Published
2021
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9. Long-term clinical outcomes after kissing balloon inflation in patients with coronary bifurcation lesions treated with provisional stenting technique. Results from the real-world multicenter registry

Author

Khelimskii, Dmitrii, primary, Bessonov, Ivan, additional, Kashtanov, Maksim, additional, Sapozhnikov, Stanislav, additional, Badoian, Aram, additional, Baranov, Aleksey, additional, Manukyan, Serezha, additional, Utegenov, Ruslan, additional, and Krestyaninov, Oleg, additional

Published
2023
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14. Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Author

De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C., additional, Ganyukov, Vladimir, additional, Busljetik, Oliver, additional, Cercek, Miha, additional, Jensen, Lisette Okkels, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Ferrer, Gerard Roura i, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto D’Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra Munoz, Victor, additional, Lee, Michael Kang-yin, additional, Juzar, Dafsah Arifa, additional, de Moura Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin Hatice, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo Lozano, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Forés, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo-Silberman, Stephane, additional, Ordoñez, Santiago, additional, Arat Özkan, Alev, additional, Scheller, Bruno, additional, Lehitola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Brum Silveira, João António, additional, Zoni, Cesar Rodrigo, additional, Bessonov, Ivan, additional, Uccello, Giuseppe, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos E., additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Gutierrez Barrios, Alejandro, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Frankie C. C., additional, Rodriguez, Alfredo, additional, Lukito, Antonia Anna, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Ielasi, Alfonso, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Burgadha, Mohammed Abed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional

Published
2023
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15. Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Author

De Luca, Giuseppe, primary, Manzo-Silberman, Stephane, additional, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C., additional, Ganyukov, Vladimir, additional, Busljetik, Oliver, additional, Cercek, Miha, additional, Okkels, Lisette, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Ferrer, Gerard Roura i, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto di Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra, Victor, additional, Lee, Michael Kang-yin, additional, Juzar, Dafsah Arifa, additional, de Moura Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin Hatice, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo Lozano, additional, Boccalatte, Marco, additional, Ojeda, Francisco Bosa, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Forés, Juan Sanchis, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Ordoñez, Santiago, additional, Arat Özkan, Alev, additional, Scheller, Bruno, additional, Lehtola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Brum Silveira, João António, additional, Zoni, Cesar Rodrigo, additional, Bessonov, Ivan, additional, Uccello, Giuseppe, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos E., additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Barrios, Alejandro Gutierrez, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Frankie C. C., additional, Rodriguez, Alfredo, additional, Lukito, Antonia Anna, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Ielasi, Alfonso, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Bouraghda, Mohamed Abed, additional, Moura, Marcia, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional

Published
2023
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16. Results of the ISACS-STEMI COVID-19 Registry

Author

De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Busljetik, Oliver, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura i., Quadros, Alexandre, Milewski, Marek, Scotto D’Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra Munoz, Victor, Lee, Michael Kang yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo-Silberman, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehitola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Cesar Rodrigo, Bessonov, Ivan, Uccello, Giuseppe, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie C.C., Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Ielasi, Alfonso, Cortese, Giuliana, Parodi, Guido, Burgadha, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
ST-segment elevation myocardial infarction, Medicine(all), ageing, COVID-19
Abstract

Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825–0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05–1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic. publishersversion published

Published
2023

17. Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI

Author

De Luca, Giuseppe, Manzo-Silberman, Stephane, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Busljetik, Oliver, Cercek, Miha, Okkels, Lisette, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura i., Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra, Victor, Lee, Michael Kang yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Ojeda, Francisco Bosa, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Forés, Juan Sanchis, Vignali, Luigi, Pereira, Helder, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Cesar Rodrigo, Bessonov, Ivan, Uccello, Giuseppe, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Barrios, Alejandro Gutierrez, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie C.C., Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Ielasi, Alfonso, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Moura, Marcia, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
ST-segment elevation myocardial infarction, Medicine(all), percutaneous coronary intervention, gender, COVID-19
Abstract

Publisher Copyright: © 2023 by the authors. Background. Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. Methods. This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March–June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality. Results. We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825–0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31–2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96–1.34], p = 0.12). Conclusions. The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number: NCT 04412655. publishersversion published

Published
2023

18. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS–STEMI COVID-19 Registry

Author

De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo, additional, Ganyukov, Vladimir, additional, Zimbakov, Zan, additional, Cercek, Miha, additional, Jensen, Lisette, additional, Loh, Poay, additional, Calmac, Lucian, additional, Ferrer, Gerard, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto D’Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra-Munoz, Victor, additional, Lee, Michael, additional, Juzar, Dafsah, additional, Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Lucia, Marinucci, additional, Vincenzo, Guiducci, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Vincent, Flavien, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Forés, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo, Stephane, additional, Ordoñez, Santiago, additional, Özkan, Alev, additional, Scheller, Bruno, additional, Lehtola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Silveira, João, additional, Zoni, Rodrigo, additional, Bessonov, Ivan, additional, Savonitto, Stefano, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos, additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Barrios, Alejandro, additional, Bachini, Juan, additional, Rocha, Alex, additional, Tam, Frankie, additional, Rodriguez, Alfredo, additional, Lukito, Antonia, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Bouraghda, Mohamed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional

Published
2022
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19. SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

Author

De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C, additional, Ganyukov, Vladimir, additional, Zimbakov, Zan, additional, Cercek, Miha, additional, Okkels Jensen, Lisette, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Roura i Ferrer, Gerard, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto Di Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra-Munoz, Victor M., additional, Kang-yin Lee, Michael, additional, Juzar, Dafsah Arifa, additional, de Moura Joaquim, Rodrigo, additional, De Simone, Ciro, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin Hatice, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Lozano Martínez-Luengas, Iñigo, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Forés, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo-Silbermann, Stephane, additional, Ordoñez, Santiago, additional, Arat Özkan, Alev, additional, Scheller, Bruno, additional, Lehtola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Brum Silveira, João António, additional, Bessonov, Ivan, additional, Zoni, Rodrigo, additional, Savonitto, Stefano, additional, Kochiadakis, George, additional, Alexopoulos, Dimitrios, additional, Uribe, Carlos E, additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Gutierrez Barrios, Alejandro, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Frankie Chor-Cheung, additional, Rodriguez, Alfredo, additional, Lukito, Antonia Anna, additional, Bellemain-Appaix, Anne, additional, Pessah, Gustavo, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Burgadha, Mohammed Abed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional

Published
2022
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20. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI

Author

De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura i., Quadros, Alexandre, Milewski, Marek, Scotto D’Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang yin, Juzar, Dafsah Arifa, Joaquim, Rodrigo de Moura, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Lucia, Marinucci, Vincenzo, Guiducci, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Vincent, Flavien, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Silveira, João António Brum, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Barrios, Alejandro Gutierrez, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Medicine(all), myocardial infarction, percutaneous coronary intervention, COVID-19, smoking paradox
Abstract

Publisher Copyright: © 2022 by the authors. The so-called “smoking paradox”, conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS–STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history. publishersversion published

Published
2022

21. Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic

Author

De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Okkels Jensen, Lisette, Loh, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang Yin, Arifa Juzar, Dafsah, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João A., Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopoulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Verdoia, Monica, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
STEMI, Pulmonary and Respiratory Medicine, SDG 3 - Good Health and Well-being, COPD, Mortality
Abstract

Publisher Copyright: © 2022. The Author(s). BACKGROUND: Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclerosis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study. METHODS: In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with primary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents. RESULTS: A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dissimilarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P = 0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjustment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI] = 0.913[0.658-1.266], P = 0.585) nor for 30-days mortality (adjusted OR [95% CI] = 0.850 [0.620-1.164], P = 0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups. CONCLUSION: This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline characteristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. TRIAL REGISTRATION NUMBER: NCT04412655 (2nd June 2020). publishersversion published

Published
2022

24. Supplemental Material - SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

Author

De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Okkels Jensen, Lisette, Loh, Poay Huan, Calmac, Lucian, Roura i Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto Di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Kang-yin Lee, Michael, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, De Simone, Ciro, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Lozano Martínez-Luengas, Iñigo, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo-Silbermann, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Bessonov, Ivan, Zoni, Rodrigo, Savonitto, Stefano, Kochiadakis, George, Alexopoulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Bellemain-Appaix, Anne, Pessah, Gustavo, Cortese, Giuliana, Parodi, Guido, Burgadha, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, and Verdoia, Monica

Subjects
Cardiology
Abstract

Supplemental Material for SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion by Giuseppe De Luca, MD, PhD, Magdy Algowhary, Berat Uguz, Dinaldo C Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura i Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto Di Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, José Luis Díez Gil, Xavier Carrillo, Maurits Dirksen, Victor M. Becerra-Munoz, Michael Kang-yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Ciro De Simone, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Lux Arpad, Marinucci Lucia, Guiducci Vincenzo, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Josè Moreu, Vincent Flavien, Enrico Fabris, Iñigo Lozano Martínez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Forés, Luigi Vignali, Helder Pereira, Stephane Manzo-Silbermann, Santiago Ordoñez, Alev Arat Özkan, Bruno Scheller, Heidi Lehtola, Rui Teles, Christos Mantis, Ylitalo Antti, João António Brum Silveira, Rodrigo Zoni, Ivan Bessonov, Stefano Savonitto, George Kochiadakis, Dimitrios Alexopoulos, Carlos E Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie Chor-Cheung Tam, Alfredo Rodriguez, Antonia Anna Lukito, Anne Bellemain-Appaix, Gustavo Pessah, Giuliana Cortese, Guido Parodi, MD, Mohammed Abed Burgadha, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Matteo Nardin, Monica Verdoia in Angiology

Published
2022
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26. COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction

Author

De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C, additional, Ganyukov, Vladimir, additional, Zimbakov, Zan, additional, Cercek, Miha, additional, Jensen, Lisette Okkels, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Roura-Ferrer, Gerard, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto di Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurriën, additional, Casella, Gianni, additional, Wong, Aaron Sung Lung, additional, Kala, Petr, additional, Diez Gil, Jose Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits Theodoor, additional, Becerra-Muñoz, Víctor Manuel, additional, Kang-yin Lee, Michael, additional, Juzar, Dafsah A, additional, de Moura Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan O, additional, Galasso, Gennaro, additional, Lux, Arpad, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Jose, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Lozano Martìnez-Luengas, Iñigo, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Fores, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo-Silberman, Stéphane, additional, Ordonez, Santiago, additional, Özkan, Alev Arat, additional, Scheller, Bruno, additional, Lehtola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Ylitalo, Antti, additional, Brum Silveira, Joao Antonio, additional, Zoni, Rodrigo, additional, Bessonov, Ivan, additional, Savonitto, Stefano, additional, Kochiadakis, George, additional, Alexopoulos, Dimitrios, additional, Uribe, Carlos, additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Gutiérrez, Alejandro, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Franckie CC, additional, Rodriguez, Alfredo, additional, Lukito, Antonia, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Bernardino, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Bouraghda, Mohamed Abed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional

Published
2021
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30. COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction

Author

De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Roura-Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrie¨n, Casella, Gianni, Wong, Aaron Sung Lung, Kala, Petr, Diez Gil, Jose Luis, Carrillo, Xavier, Dirksen, Maurits Theodoor, Becerra-Muñoz, Víctor Manuel, Kang-yin Lee, Michael, Juzar, Dafsah A, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan O, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Jose, Flavien, Vincent, Fabris, Enrico, Lozano Martìnez-Luengas, Iñigo, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Fores, Juan, Vignali, Luigi, Pereira, Helder, Manzo-Silberman, Stéphane, Ordonez, Santiago, O¨zkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Ylitalo, Antti, Brum Silveira, Joao Antonio, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopoulos, Dimitrios, Uribe, Carlos, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutiérrez, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Franckie CC, Rodriguez, Alfredo, Lukito, Antonia, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Bernardino, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, and Verdoia, Monica

Abstract

ObjectiveThe initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days).MethodsThis is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality.ResultsIn 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in door-to-balloon time (40 (25–70) min vs 40 (25–64) min, p=0.01) and total ischaemia time (225 (135–410) min vs 196 (120–355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic.ConclusionPercutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic.Trial registration numberNCT04412655.

Published
2022
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31. Fabrication of hydrogel scaffolds via photocrosslinking of methacrylated silk fibroin

Author

Bessonov, Ivan V, primary, Rochev, Yuri A, additional, Arkhipova, Аnastasia Yu, additional, Kopitsyna, Maria N, additional, Bagrov, Dmitriy V, additional, Karpushkin, Evgeny A, additional, Bibikova, Tatiana N, additional, Moysenovich, Anastasia M, additional, Soldatenko, Anna S, additional, Nikishin, Igor I, additional, Kotliarova, Maria S, additional, Bogush, Vladimir G, additional, Shaitan, Konstantin V, additional, and Moisenovich, Mihail M, additional

Published
2019
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43. Renin-Angiotensin System inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID Pandemic

Author

Luca, Giuseppe De, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Okkels, Lisette, LOH, Poay Huan, Calmac, Lucian, i Ferrer, Gerard Roura, Quadros, Alexandre, Milewski, Marek, D'Uccio, Fortunato Scotto, von Birgelen, Clemens, Versaci, Francesco, Berg, Jurrien Ten, Casella, Gianni, Lung, Aaron Wong Sung, Kala, Petr, Gil, José Luis Díez, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Kang-yin Lee, Michael, Juzar, Dafsah Arifa, Joaquim, Rodrigo de Moura, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Lucia, Marinucci, Vincenzo, Guiducci, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Mert, Kadir Ugur, Rios, Xacobe Flores, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Ojeda, Francisco Bosa, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Forés, Juan Sanchis, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Silveira, João António Brum, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Barrios, Alejandro Gutierrez, Bachini, Juan Pablo, Rocha, Alex, Tam, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Tuccillo, Gustavo Pessah Andrea, Cortese, Giuliana, Parodi, Guido, Burgadha, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, and Verdoia, Monica

Abstract

During the coronavirus disease 2019 (COVID-19) pandemic, concerns have been arisen on the use of renin-angiotensin system inhibitors (RASI) due to the potentially increased expression of Angiotensin-converting-enzyme (ACE)2 and patient's susceptibility to SARS-CoV2 infection. Diabetes mellitus have been recognized favoring the coronavirus infection with consequent increase mortality in COVID-19. No data have been so far reported in diabetic patients suffering from ST-elevation myocardial infarction (STEMI), a very high-risk population deserving of RASI treatment.

Published
2021
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46. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry

Author

Giuseppe De Luca, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura i Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto D’Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, José Luis Díez Gil, Xavier Carrillo, Maurits Dirksen, Victor M. Becerra-Munoz, Michael Kang-yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Roberto Paladino, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Lux Arpad, Marinucci Lucia, Guiducci Vincenzo, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Josè Moreu, Flavien Vincent, Enrico Fabris, Iñigo Lozano Martínez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Forés, Luigi Vignali, Helder Pereira, Stephane Manzo, Santiago Ordoñez, Alev Arat Özkan, Bruno Scheller, Heidi Lehtola, Rui Teles, Christos Mantis, Ylitalo Antti, João António Brum Silveira, Rodrigo Zoni, Ivan Bessonov, Stefano Savonitto, George Kochiadakis, Dimitrios Alexopulos, Carlos E. Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie Chor-Cheung Tam, Alfredo Rodriguez, Antonia Anna Lukito, Veauthyelau Saint-Joy, Gustavo Pessah, Andrea Tuccillo, Giuliana Cortese, Guido Parodi, Mohamed Abed Bouraghda, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Matteo Nardin, Monica Verdoia, De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkel, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura I, Quadros, Alexandre, Milewski, Marek, Scotto D'Uccio, Fortunato, von Birgelen, Clemen, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Lui, Carrillo, Xavier, Dirksen, Maurit, Becerra-Munoz, Victor M, Lee, Michael Kang-Yin, Juzar, Dafsah Arifa, Joaquim, Rodrigo de Moura, Paladino, Roberto, Milicic, Davor, Davlouros, Perikli, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Lucia, Marinucci, Vincenzo, Guiducci, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Toma, Kidawa, Michal, Moreu, Josè, Vincent, Flavien, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlo, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christo, Antti, Ylitalo, Silveira, João António Brum, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrio, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Barrios, Alejandro Gutierrez, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H01 Clinical atrial fibrillation, and YAMAÇ, AYLİN HATİCE

Subjects
ACUTE MYOCARDIAL-INFARCTION, myocardial infarction, smoking paradox, percutaneous coronary intervention, COVID-19, Temel Tıp Bilimleri, Medicine (miscellaneous), Assessment and Diagnosis, Sağlık Bilimleri, Temel Bilgi ve Beceriler, Genel Tıp, Fundamental Medical Sciences, Pathophysiology, Clinical Medicine (MED), TIP, GENEL & DAHİLİ, Hàbit de fumar, Health Sciences, Internal Medicine, Klinik Tıp (MED), ST-SEGMENT ELEVATION, Aile Sağlığı, MEDICINE, GENERAL & INTERNAL, Dahiliye, Patofizyoloji, OUTCOMES, Klinik Tıp, Fundamentals and Skills, Smoking, EXTENT, General Medicine, CLINICAL MEDICINE, Değerlendirme ve Teşhis, Tıp, TIME, Infart de miocardi, THROMBOLYTIC THERAPY, CARDIOVASCULAR-DISEASE, General Health Professions, Medicine, CORONARY-ARTERY-DISEASE, Tıp (çeşitli), CIGARETTE-SMOKING, Family Practice, Genel Sağlık Meslekleri, SMOKERS
Abstract

The so-called "smoking paradox", conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history.

Published
2022

47. Renin-Angiotensin System inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID Pandemic

Author

Giuseppe De Luca, Matteo Nardin, Magdy Algowhary, Berat Uguz, Dinaldo C Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan LOH, Lucian Calmac, Gerard Roura Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto di Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, José Luis Díez Gil, Xavier Carrillo, Maurits Dirksen, Victor M. Becerra-Munoz, Michael Kang-yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Roberto Paladino, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Arpad Lux, Lucia Marinucci, Vincenzo Guiducci, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Josè Moreu, Vincent Flavien, Enrico Fabris, Iñigo Lozano Martínez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Forés, Luigi Vignali, Helder Pereira, Stephane Manzo, Santiago Ordoñez, Alev Arat Özkan, Bruno Scheller, Heidi Lehtola, Rui Teles, Christos Mantis, Ylitalo Antti, João António Brum Silveira, Rodrigo Zoni, Ivan Bessonov, Stefano Savonitto, George Kochiadakis, Dimitrios Alexopulos, Carlos E Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie Chor-Cheung Tam, Alfredo Rodriguez, Antonia Anna Lukito, Veauthyelau Saint-Joy, Gustavo Pessah, Andrea Tuccillo, Giuliana Cortese, Guido Parodi, Mohammed Abed Bouraghda, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Monica Verdoia, De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkel, Loh, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemen, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Lung, Aaron Wong Sung, Kala, Petr, Díez Gil, José Lui, Carrillo, Xavier, Dirksen, Maurit, Becerra-Munoz, Victor M, Lee, Michael Kang-Yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Perikli, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Mert, Kadir Ugur, Flores Rios, Xacobe, Kovarnik, Toma, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlo, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christo, Antti, Ylitalo, Brum Silveira, João António, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrio, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Verdoia, Monica, RS: Carim - H01 Clinical atrial fibrillation, Cardiologie, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
Renin-angiotensin system inhibitors, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, COVID-19, 030204 cardiovascular system & hematology, STEMI, RC648-665, Diseases of the endocrine glands. Clinical endocrinology, Article, Renin-angiotensin system inhibitor, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Text mining, SDG 3 - Good Health and Well-being, 030220 oncology & carcinogenesis, Internal medicine, Pandemic, Renin–angiotensin system, Internal Medicine, Cardiology, Medicine, business
Abstract

Background: During the coronavirus disease 2019 (COVID-19) pandemic, concerns have been arisen on the use of renin-angiotensin system inhibitors (RASI) due to the potentially increased expression of Angiotensin-converting-enzyme (ACE)2 and patient's susceptibility to SARS-CoV2 infection. Diabetes mellitus have been recognized favoring the coronavirus infection with consequent increase mortality in COVID-19. No data have been so far reported in diabetic patients suffering from ST-elevation myocardial infarction (STEMI), a very high-risk population deserving of RASI treatment.Methods: The ISACS-STEMI COVID-19 registry retrospectively assessed STEMI patients treated with primary percutaneous coronary intervention (PPCI) in March/June 2019 and 2020 in 109 European high-volume primary PCI centers. This subanalysis assessed the prognostic impact of chronic RASI therapy at admission on mortality and SARS-CoV2 infection among diabetic patients.Results: Our population is represented by 3812 diabetic STEMI patients undergoing mechanical reperfusion, 2038 in 2019 and 1774 in 2020. Among 3761 patients with available data on chronic RASI therapy, between those ones with and without treatment there were several differences in baseline characteristics, (similar in both periods) but no difference in the prevalence of SARS-CoV2 infection (1.6% vs 1.3%, respectively, p = 0.786). Considering in-hospital medication, RASI therapy was overall associated with a significantly lower in-hospital mortality (3.3% vs 15.8%, p < 0.0001), consistently both in 2019 and in 2010.Conclusions: This is first study to investigate the impact of RASI therapy on prognosis and SARS-CoV2 infection of diabetic patients experiencing STEMI and undergoing PPCI during the COVID-19 pandemic. Both pre-admission chronic RASI therapy and in-hospital RASI did not negatively affected patients' survival during the hospitalization, neither increased the risk of SARS-CoV2 infection.Trial registration number: NCT04412655.

Published
2021

48. Clinical manifestations and risk factors of coronary artery disease in patients with diabetes mellitus in western Siberia.

Author

Kuznetsov, Vadim A., Yaroslavskaya, Elena I., Bessonova, Marina I., Bessonov, Ivan S., Zyrianov, Igor P., Kolunin, Grigoriy V., Krinochkin, Dmitriy V., Maryinskih, Luiza V., and Bektasheva, Anisa S.

Subjects
*CORONARY heart disease risk factors, *CORONARY artery stenosis, *MYOCARDIAL infarction, *DIABETES, *OBESITY
Abstract

Objective. To compare the prevalence of cardiovascular risk factors and clinical manifestations of coronary artery disease (CAD) between patients with type 2 diabetes mellitus (DM) and CAD who lived at northern latitudes vs. those who resided at southern latitudes in the Tyumen region, western Siberia. Study design. This retrospective study involved 382 patients with type 2 DM selected from 8,573 patients with angiographic CAD (>50% stenosis). Out of the total, 243 patients were permanent residents at the high latitudes of the Tyumen region ("northern patients"), and 139 patients were permanent residents in areas south of the Tyumen region ("southern patients"). Results. On average, northern patients were younger than southern patients (53 vs. 57 years, respectively). The odds ratio (OR) for living in the north was 2.1 (95% CI 0.99-4.53) for obesity (BMI=30 kg/m²), 1.87 (95% CI 1.05-3.31) for smoking, 0.93 (95% CI 0.89-0.96) per 1 year increase in age, 0.84 (95% CI 0.76-0.94) per 1 mmol/L increase of fasting plasma glucose, and 1.15 (95% CI 1.04-1.28) per 1 mm increase of right ventricular end-diastolic diameter. The proportion of patients with 3 or more CAD risk factors was higher in the north. Most patients in both groups had a history of myocardial infarction, severe angina in class III/IV as defined by the Canadian Cardiovascular System (CCS), heart failure in class II/IV as defined by the New York Heart Association (NYHA) and hypertension. Conclusions. A north-south gradient was observed in cardiovascular risk factors among patients with DM and CAD in the Tyumen region. The clinical manifestations of CAD in DM patients at high latitudes were comparable with those of patients who reside south of the Tyumen region of western Siberia, despite the younger age of northern patients. [ABSTRACT FROM AUTHOR]

Published
2010

49. SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion.

Author

De Luca G, Algowhary M, Uguz B, Oliveira DC, Ganyukov V, Zimbakov Z, Cercek M, Okkels Jensen L, Loh PH, Calmac L, Roura I Ferrer G, Quadros A, Milewski M, Scotto Di Uccio F, von Birgelen C, Versaci F, Ten Berg J, Casella G, Wong Sung Lung A, Kala P, Díez Gil JL, Carrillo X, Dirksen M, Becerra-Munoz VM, Kang-Yin Lee M, Juzar DA, de Moura Joaquim R, De Simone C, Milicic D, Davlouros P, Bakraceski N, Zilio F, Donazzan L, Kraaijeveld A, Galasso G, Arpad L, Marinucci L, Guiducci V, Menichelli M, Scoccia A, Yamac AH, Ugur Mert K, Flores Rios X, Kovarnik T, Kidawa M, Moreu J, Flavien V, Fabris E, Lozano Martínez-Luengas I, Boccalatte M, Bosa Ojeda F, Arellano-Serrano C, Caiazzo G, Cirrincione G, Kao HL, Sanchis Forés J, Vignali L, Pereira H, Manzo-Silbermann S, Ordoñez S, Arat Özkan A, Scheller B, Lehtola H, Teles R, Mantis C, Antti Y, Brum Silveira JA, Bessonov I, Zoni R, Savonitto S, Kochiadakis G, Alexopoulos D, Uribe CE, Kanakakis J, Faurie B, Gabrielli G, Gutierrez Barrios A, Bachini JP, Rocha A, Tam FC, Rodriguez A, Lukito AA, Bellemain-Appaix A, Pessah G, Cortese G, Parodi G, Burgadha MA, Kedhi E, Lamelas P, Suryapranata H, Nardin M, and Verdoia M

Abstract

SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older ( P = .002), less often active smokers ( P = .002), and hypercholesterolemic ( P = .006), they presented more often later than 12 h ( P = .037), more often to the hub and were more often in cardiogenic shock ( P = .02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P < .0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow ( P = .029) and more thrombectomy ( P = .046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P < .001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P < .001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P < .001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2023
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50. Modelling of hemodynamics in bifurcation lesions of coronary arteries before and after myocardial revascularization.

Author

Starodumov IO, Sokolov SY, Alexandrov DV, Zubarev AY, Bessonov IS, Chestukhin VV, and Blyakhman FA

Subjects
Hemodynamics, Humans, Myocardial Revascularization, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease surgery, Models, Cardiovascular
Abstract

Modelling of patient-specific hemodynamics for a clinical case of severe coronary artery disease with the bifurcation stenosis was carried out with allowance for standard angiographic data obtained before and after successfully performed myocardial revascularization by stenting of two arteries. Based on a non-Newtonian fluid model and an original algorithm for fluid dynamics computation operated with a limited amount of initial data, key characteristics of blood flow were determined to analyse the features of coronary disease and the consequences of its treatment. The results of hemodynamic modelling near bifurcation sites are presented with an emphasis on physical, physiological and clinical phenomena to demonstrate the feasibility of the proposed approach. The main limitations and ways to minimize them are the subjects of discussion as well. This article is part of the theme issue 'Transport phenomena in complex systems (part 2)'.

Published
2022
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