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16. Prognostic implications of the lymph node count after neoadjuvant treatment for rectal cancer

Author

Persiani, Roberto, Biondi, Alberto, Gambacorta, Maria Antonietta, Bertucci Zoccali, Marco, Vecchio, Fabio Maria, Tufo, Andrea, Coco, Claudio, Valentini, Vincenzo, Doglietto, Gb, D'Ugo, Domenico, Persiani, Roberto (ORCID:0000-0002-1537-5097), Biondi, Alberto (ORCID:0000-0002-2470-7858), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), Coco, Claudio (ORCID:0000-0002-4713-7093), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Persiani, Roberto, Biondi, Alberto, Gambacorta, Maria Antonietta, Bertucci Zoccali, Marco, Vecchio, Fabio Maria, Tufo, Andrea, Coco, Claudio, Valentini, Vincenzo, Doglietto, Gb, D'Ugo, Domenico, Persiani, Roberto (ORCID:0000-0002-1537-5097), Biondi, Alberto (ORCID:0000-0002-2470-7858), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Vecchio, Fabio Maria (ORCID:0000-0002-9197-2264), Coco, Claudio (ORCID:0000-0002-4713-7093), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), and D'Ugo, Domenico (ORCID:0000-0001-6657-6318)

Abstract

BACKGROUND: The aim of this study was to investigate the effect of neoadjuvant chemoradiotherapy on the lymph node yield of rectal cancer surgery. METHODS: Data for patients who underwent neoadjuvant chemoradiotherapy followed by surgery for resectable rectal cancer from June 1992 to June 2009 were reviewed. The primary outcomes measured were the number of lymph nodes retrieved, their status, and patient survival. RESULTS: In total, 345 patients underwent neoadjuvant chemoradiotherapy followed by surgery, and 95 patients had surgery alone. Neoadjuvant chemoradiotherapy decreased both the median (range) number of lymph nodes retrieved (7 (1-33) versus 12.5 (0-44) respectively; P < 0.001) and the number of positive lymph nodes (0 (0-11) versus 0 (0-16); P = 0.001). After neoadjuvant chemoradiotherapy, the number of retrieved lymph nodes was inversely correlated with tumour regression, and with the interval between treatment and surgery. The 5-year overall and disease-free survival rates were 86.5 and 79.1 per cent respectively. After neoadjuvant therapy, lymph node status was found to be an independent predictor of survival, whereas the number of retrieved lymph nodes did not represent a prognostic factor for either overall or disease-free survival. CONCLUSION: Low lymph node count after neoadjuvant chemoradiotherapy for rectal cancer does not signify an inadequate resection or understaging, but represents an increased sensitivity to the treatment.

Published
2014

18. Prognostic value of preoperative staging in gastric cancer

Author

Biondi, Alberto, Persiani, Roberto, Cananzi, Ferdinando Carlo Maria, Bertucci Zoccali, Marco, D'Ugo, Domenico, Biondi, Alberto (ORCID:0000-0002-2470-7858), Persiani, Roberto (ORCID:0000-0002-1537-5097), D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Biondi, Alberto, Persiani, Roberto, Cananzi, Ferdinando Carlo Maria, Bertucci Zoccali, Marco, D'Ugo, Domenico, Biondi, Alberto (ORCID:0000-0002-2470-7858), Persiani, Roberto (ORCID:0000-0002-1537-5097), and D'Ugo, Domenico (ORCID:0000-0001-6657-6318)

Published
2011

19. Do perioperative blood transfusions influence prognosis of gastric cancer patients? Analysis of 927 patients and interactions with splenectomy

Author

Pacelli, Fabio, Rosa, Francesco, Marrelli, D, Pedrazzani, C, Bossola, Maurizio, Bertucci Zoccali, Marco, Marchet, A, Di Cosmo, M, Roata, C, Graziosi, L, Cavazzoni, E, Covino, Marcello, D'Ugo, Domenico, Roviello, F, Nitti, D, Doglietto, Gb, Pacelli, Fabio (ORCID:0000-0002-2013-6525), Bossola, Maurizio (ORCID:0000-0003-1627-0235), Covino, Marcello (ORCID:0000-0002-6709-2531), D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Pacelli, Fabio, Rosa, Francesco, Marrelli, D, Pedrazzani, C, Bossola, Maurizio, Bertucci Zoccali, Marco, Marchet, A, Di Cosmo, M, Roata, C, Graziosi, L, Cavazzoni, E, Covino, Marcello, D'Ugo, Domenico, Roviello, F, Nitti, D, Doglietto, Gb, Pacelli, Fabio (ORCID:0000-0002-2013-6525), Bossola, Maurizio (ORCID:0000-0003-1627-0235), Covino, Marcello (ORCID:0000-0002-6709-2531), and D'Ugo, Domenico (ORCID:0000-0001-6657-6318)

Abstract

This study was to assess the influence of perioperative blood transfusions on the prognosis of patients undergoing a potentially curative resection for gastric cancer and to investigate the interaction between transfusions and splenectomy.

Published
2011

20. Education and imaging: gastrointestinal: videocapsule retention: rationale for surgical indication

Author

Biondi, Alberto, Persiani, Roberto, Vigorita, Vincenzo, Cananzi, Ferdinando Carlo Maria, Bertucci Zoccali, Marco, D'Ugo, Domenico, Biondi, Alberto (ORCID:0000-0002-2470-7858), Persiani, Roberto (ORCID:0000-0002-1537-5097), D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Biondi, Alberto, Persiani, Roberto, Vigorita, Vincenzo, Cananzi, Ferdinando Carlo Maria, Bertucci Zoccali, Marco, D'Ugo, Domenico, Biondi, Alberto (ORCID:0000-0002-2470-7858), Persiani, Roberto (ORCID:0000-0002-1537-5097), and D'Ugo, Domenico (ORCID:0000-0001-6657-6318)

Abstract

No abstract is available for this article.

Published
2011

21. R0 resection in the treatment of gastric cancer: room for improvement

Author

Biondi, Alberto, Persiani, Roberto, Cananzi, Ferdinando Carlo Maria, Bertucci Zoccali, Marco, Vigorita, Vincenzo, Tufo, Andrea, D'Ugo, Domenico, Biondi, Alberto (ORCID:0000-0002-2470-7858), Persiani, Roberto (ORCID:0000-0002-1537-5097), D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Biondi, Alberto, Persiani, Roberto, Cananzi, Ferdinando Carlo Maria, Bertucci Zoccali, Marco, Vigorita, Vincenzo, Tufo, Andrea, D'Ugo, Domenico, Biondi, Alberto (ORCID:0000-0002-2470-7858), Persiani, Roberto (ORCID:0000-0002-1537-5097), and D'Ugo, Domenico (ORCID:0000-0001-6657-6318)

Abstract

Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor. In particular, lymphatic metastasis is one of the main predictors of tumor recurrence and survival, and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection. This is compounded by the observation that two-thirds of gastric cancer in the Western world presents at an advanced stage, with lymph node metastasis at diagnosis. All current therapeutic efforts in gastric cancer are directed toward individualization of therapeutic protocols, tailoring the extent of resection and the administration of preoperative and postoperative treatment. The goals of all these strategies are to improve prognosis towards the achievement of a curative resection (R0 resection) with minimal morbidity and mortality, and better postoperative quality of life.

Published
2010

22. Surgical issues after neoadjuvant treatment for gastric cancer

Author

D'Ugo, Domenico, Persiani, Roberto, Bertucci Zoccali, Marco, Cananzi, Ferdinando Carlo Maria, Vigorita, Vincenzo, Mazzeo, Pasquale, Tufo, Andrea, Biondi, Alberto, D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Persiani, Roberto (ORCID:0000-0002-1537-5097), Biondi, Alberto (ORCID:0000-0002-2470-7858), D'Ugo, Domenico, Persiani, Roberto, Bertucci Zoccali, Marco, Cananzi, Ferdinando Carlo Maria, Vigorita, Vincenzo, Mazzeo, Pasquale, Tufo, Andrea, Biondi, Alberto, D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Persiani, Roberto (ORCID:0000-0002-1537-5097), and Biondi, Alberto (ORCID:0000-0002-2470-7858)

Abstract

Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior depends on the metastatic potential of the tumour. Particularly, lymphatic metastasis is one of the main predictor of tumour recurrence and survival and current pathologic staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients resected with curative intent. This is deducted by the observation that two thirds of gastric cancers in the western world present at an advanced stage, with nearly 85% of tumors accompanied by lymph node metastasis at diagnosis. To date most therapeutic efforts are directed toward individualization of therapeutic protocols, tailoring the extent of resection integrated by the administration of preoperative and postoperative treatment. The goal of such strategies is to improve prognosis towards the achievement of a curative resection (R0-resection) with minimal morbidity and mortality, with better postoperative quality of life. A brief review of literature about preoperative therapy for gastric carcinoma will be herein illustrated. The rationale and the general drawbacks of preoperative treatments will be both discussed in order to demonstrate its value in terms of safety and efficacy.

Published
2010

23. Large bowel auto-amputation and passage of a colon 'cast' after left hemicolectomy

Author

Biondi, Alberto, Persiani, Roberto, Rausei, Stefano, Cananzi, Ferdinando Carlo Maria, Bertucci Zoccali, Marco, Vecchioli Scaldazza, Amorino, D'Ugo, Domenico, Biondi, Alberto (ORCID:0000-0002-2470-7858), Persiani, Roberto (ORCID:0000-0002-1537-5097), D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Biondi, Alberto, Persiani, Roberto, Rausei, Stefano, Cananzi, Ferdinando Carlo Maria, Bertucci Zoccali, Marco, Vecchioli Scaldazza, Amorino, D'Ugo, Domenico, Biondi, Alberto (ORCID:0000-0002-2470-7858), Persiani, Roberto (ORCID:0000-0002-1537-5097), and D'Ugo, Domenico (ORCID:0000-0001-6657-6318)

Abstract

No abstract available

Published
2008

24. Determinants of surgical morbidity in gastric cancer treatment

Author

Persiani, Roberto, Antonacci, Vincenzo, Biondi, Alberto, Rausei, Stefano, La Greca, Antonio, Bertucci Zoccali, Marco, Ciccoritti, Luigi, D'Ugo, Domenico, Persiani, Roberto (ORCID:0000-0002-1537-5097), Biondi, Alberto (ORCID:0000-0002-2470-7858), La Greca, Antonio (ORCID:0000-0002-7587-7427), D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Persiani, Roberto, Antonacci, Vincenzo, Biondi, Alberto, Rausei, Stefano, La Greca, Antonio, Bertucci Zoccali, Marco, Ciccoritti, Luigi, D'Ugo, Domenico, Persiani, Roberto (ORCID:0000-0002-1537-5097), Biondi, Alberto (ORCID:0000-0002-2470-7858), La Greca, Antonio (ORCID:0000-0002-7587-7427), and D'Ugo, Domenico (ORCID:0000-0001-6657-6318)

Abstract

The occurrence of early surgical complications after gastrectomy as a treatment for gastric cancer has been reported to have a negative impact on longterm survival. The aim of this study was to identify treatment-related factors that can predict morbidity and mortality in patients undergoing operations for gastric cancer.

Published
2008

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