12,737 results on '"Bertucci A"'
Search Results
2. VAE Explainer: Supplement Learning Variational Autoencoders with Interactive Visualization
- Author
-
Bertucci, Donald and Endert, Alex
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Variational Autoencoders are widespread in Machine Learning, but are typically explained with dense math notation or static code examples. This paper presents VAE Explainer, an interactive Variational Autoencoder running in the browser to supplement existing static documentation (e.g., Keras Code Examples). VAE Explainer adds interactions to the VAE summary with interactive model inputs, latent space, and output. VAE Explainer connects the high-level understanding with the implementation: annotated code and a live computational graph. The VAE Explainer interactive visualization is live at https://xnought.github.io/vae-explainer and the code is open source at https://github.com/xnought/vae-explainer., Comment: 6 pages, 4 figures
- Published
- 2024
3. Curvature in chemotaxis: A model for ant trail pattern formation
- Author
-
Bertucci, Charles, Rakotomalala, Matthias, and Tomasevic, Milica
- Subjects
Mathematics - Analysis of PDEs - Abstract
In this paper, we propose a new model of chemotaxis motivated by ant trail pattern formation, formulated as a coupled parabolic-parabolic local PDE system, for the population density and the chemical field. The main novelty lies in the transport term of the population density, which depends on the second-order derivatives of the chemical field. This term is derived as an anticipation-reaction steering mechanism of an infinitesimally small ant as its size approaches zero. We establish global-in-time existence and uniqueness for the model, and the propagation of regularity from the initial data. Then, we build a numerical scheme and present various examples that provide hints of trail formation.
- Published
- 2024
4. Price-Aware Automated Market Makers: Models Beyond Brownian Prices and Static Liquidity
- Author
-
Bergault, Philippe, Bertucci, Louis, Bouba, David, Guéant, Olivier, and Guilbert, Julien
- Subjects
Quantitative Finance - Trading and Market Microstructure - Abstract
In this paper, we introduce a suite of models for price-aware automated market making platforms willing to optimize their quotes. These models incorporate advanced price dynamics, including stochastic volatility, jumps, and microstructural price models based on Hawkes processes. Additionally, we address the variability in demand from liquidity takers through models that employ either Hawkes or Markov-modulated Poisson processes. Each model is analyzed with particular emphasis placed on the complexity of the numerical methods required to compute optimal quotes.
- Published
- 2024
5. Strategic geometric graphs through mean field games
- Author
-
Bertucci, Charles and Rakotomalala, Matthias
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Probability - Abstract
We exploit the structure of geometric graphs on Riemannian manifolds to analyze strategic dynamic graphs at the limit, when the number of nodes tends to infinity. This framework allows to preserve intrinsic geometrical information about the limiting graph structure, such as the Ollivier curvature. After introducing the setting, we derive a mean field game system, which models a strategic equilibrium between the nodes. It has the usual structure with the distinction of being set on a manifold. Finally, we establish existence and uniqueness of solutions to the system when the Hamiltonian is quadratic for a class of non-necessarily compact Riemannian manifolds, referred to as manifolds of bounded geometry.
- Published
- 2024
6. Dark Matter Line Searches with the Cherenkov Telescope Array
- Author
-
Abe, S., Abhir, J., Abhishek, A., Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Alfaro, R., Alvarez-Crespo, N., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrosi, G., Angel, L., Aramo, C., Arcaro, C., Arnesen, T. T. H., Arrabito, L., Asano, K., Ascasibar, Y., Aschersleben, J., Ashkar, H., Backes, M., Baktash, A., Balazs, C., Balbo, M., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Batković, I., Batzofin, R., Baxter, J., González, J. Becerra, Beck, G., Benbow, W., Berge, D., Bernardini, E., Bernete, J., Bernlöhr, K., Berti, A., Bertucci, B., Bhattacharjee, P., Bhattacharyya, S., Bigongiari, C., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Bolmont, J., Bonnoli, G., Bonollo, A., Bordas, P., Bosnjak, Z., Bottacini, E., Böttcher, M., Bringmann, T., Bronzini, E., Brose, R., Brown, A. M., Brunelli, G., Bulgarelli, A., Bulik, T., Burelli, I., Burmistrov, L., Burton, M., Buscemi, M., Bylund, T., Cailleux, J., Campoy-Ordaz, A., Cantlay, B. K., Capasso, G., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, A., Carosi, R., Carquin, E., Carrasco, M. -S., Cassol, F., Castaldini, L., Castrejon, N., Castro-Tirado, A. J., Cerasole, D., Cerruti, M., Chadwick, P. M., Chaty, S., Chen, A. W., Chernyakova, M., Chiavassa, A., Chudoba, J., Chytka, L., Cicciari, G. M., Cifuentes, A., Araujo, C. H. Coimbra, Colapietro, M., Conforti, V., Conte, F., Contreras, J. L., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cuevas, O., Curtis-Ginsberg, Z., D'Amico, G., D'Ammando, F., Dai, S., Dalchenko, M., Dazzi, F., De Angelis, A., de Lavergne, M. de Bony, De Caprio, V., Pino, E. M. de Gouveia Dal, De Lotto, B., De Lucia, M., de Menezes, R., de Naurois, M., de Souza, V., del Peral, L., del Valle, M. V., Giler, A. G. Delgado, Mengual, J. Delgado, Delgado, C., Dell'aiera, M., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Piano, A., Di Pierro, F., Di Tria, R., Di Venere, L., Díaz, C., Diebold, S., Dinesh, A., Djuvsland, J., Dominik, R. M., Prester, D. Dominis, Donini, A., Dorner, D., Dörner, J., Doro, M., Dournaux, J. -L., Duangchan, C., Dubos, C., Ducci, L., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Elsässer, D., Emery, G., Errando, M., Escanuela, C., Escarate, P., Godoy, M. Escobar, Escudero, J., Esposito, P., Ettori, S., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrarotto, F., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Guiteras, L. Font, Fontaine, G., Fröse, S., Fukazawa, Y., Fukui, Y., Furniss, A., Galanti, G., Galaz, G., Galelli, C., Gallozzi, S., Gammaldi, V., Garczarczyk, M., Gasbarra, C., Gasparrini, D., Ghalumyan, A., Gianotti, F., Giarrusso, M., Paiva, J. G. Giesbrecht Formiga, Giglietto, N., Giordano, F., Giuffrida, R., Glicenstein, J. -F., Glombitza, J., Goldoni, P., González, J. M., González, M. M., Coelho, J. Goulart, Gradetzke, T., Granot, J., Grasso, D., Grau, R., Gréaux, L., Green, D., Green, J. G., Grolleron, G., Guedes, L. M. V., Gueta, O., Hackfeld, J., Hadasch, D., Hamal, P., Hanlon, W., Hara, S., Harvey, V. M., Hassan, T., Hayashi, K., Heß, B., Heckmann, L., Heller, M., Cadena, S. Hernández, Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Iarlori, M., Inada, T., Incardona, F., Inoue, S., Inoue, Y., Iocco, F., Iori, M., Ishio, K., Jamrozy, M., Janecek, P., Jankowsky, F., Jean, P., Quiles, J. Jimenez, Jin, W., Juramy-Gilles, C., Jurysek, J., Kagaya, M., Kalekin, O., Karas, V., Katagiri, H., Kataoka, J., Kaufmann, S., Kazanas, D., Kerszberg, D., Kieda, D. B., Kleiner, T., Kluge, G., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kosack, K., Kowal, G., Kubo, H., Kushida, J., La Barbera, A., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Laporte, P., Lazarević, S., Lazendic-Galloway, J., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leonora, E., Leto, G., Lindfors, E., Linhoff, M., Liodakis, I., Lipniacka, A., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Bahilo, J. Lozano, Luque-Escamilla, P. L., Macias, O., Majumdar, P., Mallamaci, M., Malyshev, D., Mandat, D., Manicò, G., Mariotti, M., Márquez, I., Marquez, P., Marsella, G., Martí, J., Martínez, G. A., Martínez, M., Martinez, O., Marty, C., Mas-Aguilar, A., Mastropietro, M., Mazin, D., Menchiari, S., Mestre, E., Meunier, J. -L., Meyer, D. M. -A., Meyer, M., Miceli, D., Miceli, M., Michailidis, M., Michałowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mizote, M., Mizuno, T., Moderski, R., Molero, M., Molfese, C., Molina, E., Montaruli, T., Moralejo, A., Morcuende, D., Morselli, A., Moulin, E., Zamanillo, V. Moya, Munari, K., Murach, T., Muraczewski, A., Muraishi, H., Nakamori, T., Nayak, A., Nemmen, R., Neto, J. P., Nickel, L., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Nikolić, L., Nishijima, K., Noda, K., Nosek, D., Novotny, V., Nozaki, S., Ohishi, M., Ohtani, Y., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Orlando, S., Ostrowski, M., Otero-Santos, J., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Panebianco, G., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pe'er, A., Pech, M., Pecimotika, M., Pensec, U., Peresano, M., Pérez-Romero, J., Persic, M., Peters, K. P., Petruk, O., Piano, G., Pierre, E., Pietropaolo, E., Pihet, M., Pinchbeck, L., Pirola, G., Pittori, C., Plard, C., Podobnik, F., Pohl, M., Pollet, V., Ponti, G., Prandini, E., Principe, G., Priyadarshi, C., Produit, N., Prouza, M., Pueschel, E., Pühlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Regeard, M., Reimer, A., Reimer, O., Reisenegger, A., Rhode, W., Ribeiro, D., Ribó, M., Ricci, C., Richtler, T., Rico, J., Rieger, F., Riitano, L., Rizi, V., Roache, E., Fernandez, G. Rodriguez, Frías, M. D. Rodríguez, Rodríguez-Vázquez, J. J., Romano, P., Romeo, G., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Ruiter, A. J., Rulten, C. B., Sadeh, I., Saha, L., Saito, T., Salzmann, H., Sánchez-Conde, M., Sandaker, H., Sangiorgi, P., Sano, H., Santander, M., Santos-Lima, R., Sapienza, V., Šarić, T., Sarkar, A., Sarkar, S., Saturni, F. G., Savarese, S., Scherer, A., Schiavone, F., Schipani, P., Schleicher, B., Schovanek, P., Schubert, J. L., Schwanke, U., Arroyo, M. Seglar, Seitenzahl, I. R., Sergijenko, O., Servillat, M., Siegert, T., Siejkowski, H., Siqueira, C., Sliusar, V., Slowikowska, A., Sol, H., Spencer, S. T., Spiga, D., Stamerra, A., Stanič, S., Starecki, T., Starling, R., Stawarz, Ł., Steppa, C., Hatlen, E. Sæther, Stolarczyk, T., Strišković, J., Suda, Y., Świerk, P., Tajima, H., Tak, D., Takahashi, M., Takeishi, R., Tavernier, T., Tejedor, L. A., Terauchi, K., Teshima, M., Testa, V., Tian, W. W., Tibaldo, L., Tibolla, O., Peixoto, C. J. Todero, Torradeflot, F., Torres, D. F., Tosti, G., Tothill, N., Toussenel, F., Tramacere, A., Travnicek, P., Tripodo, G., Trois, A., Truzzi, S., Tutone, A., Vaclavek, L., Vacula, M., Vallania, P., Vallés, R., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Verna, G., Viana, A., Viaux, N., Vigliano, A., Vignatti, J., Vigorito, C. F., Villanueva, J., Visentin, E., Vitale, V., Vodeb, V., Voisin, V., Voitsekhovskyi, V., Vorobiov, S., Voutsinas, G., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., White, M., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wohlleben, F., Wolter, A., Yamamoto, T., Yang, L., Yoshida, T., Yoshikoshi, T., Zaharijas, G., Zampieri, L., Sanchez, R. Zanmar, Zavrtanik, D., Zavrtanik, M., Zdziarski, A. A., Zech, A., Zhang, W., Zhdanov, V. I., Ziętara, K., Živec, M., and Zuriaga-Puig, J.
- Subjects
High Energy Physics - Phenomenology ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment - Abstract
Monochromatic gamma-ray signals constitute a potential smoking gun signature for annihilating or decaying dark matter particles that could relatively easily be distinguished from astrophysical or instrumental backgrounds. We provide an updated assessment of the sensitivity of the Cherenkov Telescope Array (CTA) to such signals, based on observations of the Galactic centre region as well as of selected dwarf spheroidal galaxies. We find that current limits and detection prospects for dark matter masses above 300 GeV will be significantly improved, by up to an order of magnitude in the multi-TeV range. This demonstrates that CTA will set a new standard for gamma-ray astronomy also in this respect, as the world's largest and most sensitive high-energy gamma-ray observatory, in particular due to its exquisite energy resolution at TeV energies and the adopted observational strategy focussing on regions with large dark matter densities. Throughout our analysis, we use up-to-date instrument response functions, and we thoroughly model the effect of instrumental systematic uncertainties in our statistical treatment. We further present results for other potential signatures with sharp spectral features, e.g.~box-shaped spectra, that would likewise very clearly point to a particle dark matter origin., Comment: 44 pages JCAP style (excluding author list and references), 19 figures; minor changes to match published version
- Published
- 2024
- Full Text
- View/download PDF
7. Bicycle Set-Up Dimensions and Cycling Kinematics: A Consensus Statement Using Delphi Methodology
- Author
-
Priego-Quesada, Jose Ignacio, Arkesteijn, Marco, Bertucci, William, Bini, Rodrigo R., Carpes, Felipe P., Diefenthaeler, Fernando, Dorel, Sylvain, Fonda, Borut, Gatti, Anthony A., Holliday, Wendy, Janssen, Ina, Elvira, Jose L. López, Millour, Geoffrey, Perez-Soriano, Pedro, Swart, Jeroen, Visentini, Paul, Zhang, Songning, and Encarnación-Martínez, Alberto
- Published
- 2024
- Full Text
- View/download PDF
8. A two spaces extension of Cauchy-Lipschitz Theorem
- Author
-
Bertucci, Charles and Lions, Pierre Louis
- Subjects
Mathematics - Analysis of PDEs - Abstract
We adapt the classical theory of local well-posedness of evolution problems to cases in which the nonlinearity can be accurately quantified by two different norms. For ordinary differential equations, we consider $\dot{x} = f(x,x)$ for a function $f: V\times E \to E$ where $E$ is a Banach space and $V \hookrightarrow E$ a normed vector space. This structure allows us to distinguish between the two dependencies of $f$ in $x$ and allows to generalize classical results. We also prove a similar results for partial differential equations.
- Published
- 2024
9. A spectral dominance approach to large random matrices: part II
- Author
-
Bertucci, Charles, Lasry, Jean-Michel, and Lions, Pierre Louis
- Subjects
Mathematics - Analysis of PDEs - Abstract
This paper is the second of a series devoted to the study of the dynamics of the spectrum of large random matrices. We study general extensions of the partial differential equation arising to characterize the limit spectral measure of the Dyson Brownian motion. We provide a regularizing result for those generalizations. We also show that several results of part I extend to cases in which there is no spectral dominance property. We then provide several modeling extensions of such models as well as several identities for the Dyson Brownian motion.
- Published
- 2024
10. Positivity Bounds on Massive Vectors
- Author
-
Bertucci, Francesco, Henriksson, Johan, McPeak, Brian, Ricossa, Sergio, Riva, Francesco, and Vichi, Alessandro
- Subjects
High Energy Physics - Theory - Abstract
In this paper, we explore positivity bounds for the effective field theory~(EFT) of a single weakly coupled massive vector field. The presence of both mass and spin makes the crossing properties of the amplitudes vastly complicated -- we address this by parametrizing the amplitudes as products of a polarization matrix and a vector of appropriately chosen functions with simpler crossing properties. The resulting framework involves sum rules and null constraints that allows us to constrain any combination of low-energy observables, such as EFT amplitudes. By varying the value of the vector mass over the cutoff scale, some of our bounds asymptote to the bounds obtained in the context of photons and massless scalars. This work paves the way for future applications to e.g. non-abelian massive vectors, glueballs and theories with spin larger than one.
- Published
- 2024
11. Noise through an additional variable for mean field games master equation on finite state space
- Author
-
Bertucci, Charles and Meynard, Charles
- Subjects
Mathematics - Analysis of PDEs - Abstract
This paper provides a mathematical study of the well-posedness of master equation on finite state space involving terms modelling common noise. In this setting, the solution of the master equation depends on an additional variable modelling the value of a stochastic process impacting all players. Using technique from viscosity solutions, we give sufficient conditions for the existence of a Lipschitz continuous solution on any time interval. Under some structural assumptions, we are even able to treat cases in which the dynamics of this stochastic process depend on the state of the game.
- Published
- 2024
12. Combination of Elastic Nail(s) and Cementoplasty to Treat Pathological Fractures in Long Bones of the Upper Limb
- Author
-
Garnon, Julien, Autrusseau, Pierre-Alexis, Caudrelier, Jean, Weiss, Julia, Bertucci, Gregory, Koch, Guillaume, Gangi, Afshin, and Cazzato, Roberto Luigi
- Published
- 2024
- Full Text
- View/download PDF
13. Coral reef fish density at a tourist destination responded rapidly to COVID-19 restrictions
- Author
-
Gairin, Emma, Bertucci, Frédéric, Roux, Natacha, Minier, Lana, Berthe, Cécile, Waqalevu, Viliame, Maueau, Tehani, Sturny, Vincent, Sang, Gaston Tong, Mills, Suzanne C., and Lecchini, David
- Published
- 2024
- Full Text
- View/download PDF
14. Invertebrate sounds from photic to mesophotic coral reefs reveal vertical stratification and diel diversity
- Author
-
Raick, Xavier, Parmentier, Éric, Gervaise, Cédric, Lecchini, David, Pérez-Rosales, Gonzalo, Rouzé, Héloïse, Bertucci, Frédéric, and Di Iorio, Lucia
- Published
- 2024
- Full Text
- View/download PDF
15. MR-Guided Transurethral Ultrasound Ablation (TULSA)—An Emerging Minimally Invasive Treatment Option for Localised Prostate Cancer
- Author
-
Fung, Kin Fen Kevin, Cazzato, Roberto Luigi, Tricard, Thibault, Marini, Pierre D. E., Bertucci, Gregory, Autrusseau, Pierre-Alexis, Koch, Guillaume, Weiss, Julia, Garnon, Julien, Lang, Hervé, and Gangi, Afshin
- Published
- 2024
- Full Text
- View/download PDF
16. Four-week experimental plus 1-week taper period using live high train low does not alter muscle glycogen content
- Author
-
Bertucci, Danilo R., de Carvalho, Carlos Dellavechia, Scariot, Pedro P. M., Kalva-Filho, Carlos A., Luches-Pereira, Gabriel, Arruda, Tarine B., Alves, Isabela S., Gardim, Camila B., Castiglia, Marcelo, Riberto, Marcelo, Gobatto, Claudio Alexandre, and Papoti, Marcelo
- Published
- 2024
- Full Text
- View/download PDF
17. Automated market makers: mean-variance analysis of LPs payoffs and design of pricing functions
- Author
-
Bergault, Philippe, Bertucci, Louis, Bouba, David, and Guéant, Olivier
- Published
- 2024
- Full Text
- View/download PDF
18. Effect of Wearing a New Prophylactic Orthosis on Postural Balance
- Author
-
Romain, Julien, Arfaoui, Ahlem, and Bertucci, William
- Subjects
Quantitative Biology - Quantitative Methods - Abstract
Purpose: The purpose of this study is to evaluate the effect of an innovative prophylactic knee orthosis on postural balance. This prophylactic knee orthosis is designed with a compression that is oriented in a chosen direction. The purpose of this compression is to improve stability in dynamic situations. Orthoses are used to provide functional improvements to knee problems. However, more scientific validation is needed for this type of product. Methods: 20 sportsmen in team sports performed a functional test: the Y-Balance Test. This reliable and reproducible test allows to evaluate the postural balance of the lower limb. The subjects were tested in 3 conditions: prophylactic orthosis with innovative compression, control orthosis (with no compression) and without orthosis. The average of the three trials were collected in each direction and condition. Results: The prophylactic orthosis had a better standardized score in the anterior direction (p<0.05) and a better composite score (p<0.05) than the control orthosis (no compression). However, there were no differences in the normalized score in the other directions. There were no significant differences between the prophylactic orthosis and without orthosis. Conclusion:Wearing the prophylactic orthosis improves postural balance compared to a orthosis with no compression. But there is no difference between the prophylactic orthosis and without orthosis on postural balance.
- Published
- 2023
- Full Text
- View/download PDF
19. Joint Optimization of Charging Infrastructure Placement and Operational Schedules for a Fleet of Battery Electric Trucks
- Author
-
Bertucci, Juan Pablo, Hofman, Theo, and Salazar, Mauro
- Subjects
Electrical Engineering and Systems Science - Systems and Control - Abstract
This paper examines the challenges and requirements for transitioning logistic distribution networks to electric fleets. To maintain their current operations, fleet operators need a clear understanding of the charging infrastructure required and its relationship to existing power grid limitations and fleet schedules. In this context, this paper presents a modeling framework to optimize the charging infrastructure and charging schedules for a logistic distribution network in a joint fashion. Specifically, we cast the joint infrastructure design and operational scheduling problem as a mixed-integer linear program that can be solved with off-the-shelf optimization algorithms providing global optimality guarantees. For a case study in the Netherlands, we assess the impact of different parameters in our optimization problem, specifically, the allowed deviation from existing operations with conventional diesel trucks and the cost factor for daily peak energy usage. We examine the effects on infrastructure design and power requirements, comparing our co-design algorithm with planned infrastructure solutions. The results indicate that current charging and electric machine technologies for trucks can perform the itineraries of conventional trucks for our case study, but to maintain critical time requirements and navigate grid congestion co-design can have a significant impact in reducing total cost of ownership (average 3.51% decrease in total costs compared to rule-based design solutions).
- Published
- 2023
20. Prospects for $\gamma$-ray observations of the Perseus galaxy cluster with the Cherenkov Telescope Array
- Author
-
Consortium, The Cherenkov Telescope Array, Abe, K., Abe, S., Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Alfaro, R., Alvarez-Crespo, N., Batista, R. Alves, Amans, J. -P., Amato, E., Angüner, E. O., Antonelli, L. A., Aramo, C., Araya, M., Arcaro, C., Arrabito, L., Asano, K., Ascasíbar, Y., Aschersleben, J., Ashkar, H., Stuani, L. Augusto, Baack, D., Backes, M., Baktash, A., Balazs, C., Balbo, M., Ballester, O., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Batista, P. I., Batkovic, I., Batzofin, R., Baxter, J., González, J. Becerra, Beck, G., Tjus, J. Becker, Benbow, W., Medrano, J. Bernete, Bernlöhr, K., Berti, A., Bertucci, B., Beshley, V., Bhattacharjee, P., Bhattacharyya, S., Bi, B., Biederbeck, N., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Boisson, C., Bolmont, J., Bordas, P., Bosnjak, Z., Bottacini, E., Bradascio, F., Braiding, C., Bronzini, E., Brose, R., Brown, A. M., Brun, F., Brunetti, G., Bucciantini, N., Bulgarelli, A., Burelli, I., Burmistrov, L., Burton, M., Bylund, T., Calisse, P. G., Campoy-Ordaz, A., Cantlay, B. K., Capalbi, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, R., Carquin, E., Carrasco, M. -S., Cascone, E., Cassol, F., Castro-Tirado, A. J., Cerasole, D., Cerruti, M., Chadwick, P., Chaty, S., Chen, A. W., Chernyakova, M., Chiavassa, A., Chudoba, J., Chytka, L., Cifuentes, A., Araujo, C. H. Coimbra, Conforti, V., Conte, F., Contreras, J. L., Cortina, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cuevas, O., Curtis-Ginsberg, Z., D'Amico, G., D'Ammando, F., Dalchenko, M., Dazzi, F., de Lavergne, M. de Bony, De Caprio, V., Laadim, F. De Frondat, Pino, E. M. de Gouveia Dal, De Lotto, B., De Lucia, M., De Martino, D., de Menezes, R., de Naurois, M., De Simone, N., de Souza, V., del Valle, M. V., Delagnes, E., Giler, A. G. Delgado, Delgado, C., Dell'aiera, M., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Piano, A., Di Pierro, F., Di Tria, R., Di Venere, L., Diebold, S., Djannati-Ataï, A., Djuvsland, J., Dominik, R. M., Donini, A., Dorner, D., Dörner, J., Doro, M., Anjos, R. D. C. dos, Dournaux, J. -L., Duangchan, C., Dubos, C., Dumora, D., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Elsässer, D., Emery, G., Godoy, M. Escobar, Escudero, J., Esposito, P., Ettori, S., Evoli, C., Falceta-Goncalves, D., Ramazani, V. Fallah, Fattorini, A., Faure, A., Fedorova, E., Fegan, S., Feijen, K., Feng, Q., Ferrand, G., Ferrarotto, F., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Foffano, L., Guiteras, L. Font, Fontaine, G., Fröse, S., Fukazawa, Y., Fukui, Y., Gaggero, D., Galanti, G., Gallozzi, S., Gammaldi, V., Garczarczyk, M., Gasbarra, C., Gasparrini, D., Gaug, M., Ghalumyan, A., Gianotti, F., Giarrusso, M., Giesbrecht, J., Giglietto, N., Giordano, F., Glicenstein, J. -F., Göksu, H., Goldoni, P., González, J. M., González, M. M., Coelho, J. Goulart, Granot, J., Grau, R., Gréaux, L., Green, D., Green, J. G., Grenier, I., Grolleron, G., Grube, J., Gueta, O., Hackfeld, J., Hadasch, D., Hamal, P., Hanlon, W., Hara, S., Harvey, V. M., Hassan, T., Heckmann, L., Heller, M., Cadena, S. Hernández, Hervet, O., Hie, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hoang, J., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hrupec122, D., Hütten, M., Iarlori, M., Inada, T., Incardona, F., Inoue, S., Iocco, F., Iori, M., Jamrozy, M., Janecek, P., Jankowsky, F., Jarnot, C., Jean, P., Martínez, I. Jiménez, Jin, W., Juramy-Gilles, C., Jurysek, J., Kagaya, M., Kantzas, D., Karas, V., Katagiri, H., Kataoka, J., Kaufmann, S., Kerszberg, D., Khélifi, B., Kissmann, R., Kleiner, T., Kluge, G., Kluźniak, W., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kosack, K., Kowal, G., Kubo, H., Kushida, J., La Barbera, A., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Laporte, P., Lazarević, S., Leitgeb, F., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leto, G., Leuschner, F., Lindfors, E., Linhoff, M., Liodakis, I., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Luque-Escamilla, P. L., Macias, O., Mackey, J., Majumdar, P., Malyshev, D., Mandat, D., Manganaro, M., Manicò, G., Mariotti, M., Markoff, S., Márquez, I., Marquez, P., Marsella, G., Martínez, G. A., Martínez, M., Martinez, O., Marty, C., Mas-Aguilar, A., Mastropietro, M., Maurin, G., Mazin, D., Melkumyan, D., Mello, A. J. T. S., Meunier, J. -L., Meyer, D. M. -A., Meyer, M., Miceli, D., Michailidis, M., Michałowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mizote, M., Mizuno, T., Moderski, R., Molero, M., Molfese, C., Molina, E., Montaruli, T., Morcuende, D., Morik, K., Morlino, G., Morselli, A., Moulin, E., Zamanillo, V. Moya, Munari, K., Murach, T., Muraczewski, A., Muraishi, H., Nagataki, S., Nakamori, T., Nemmen, R., Neyroud, N., Nickel, L., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Nishijima, K., Noda, K., Nosek, D., Novotny, V., Nozaki, S., O'Brien, P., Ohishi, M., Ohtani, Y., Okumura, A., Olive, J. -F., Olmi, B., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Ostrowski, M., Oya, I., Pagliaro, A., Palatiello, M., Panebianco, G., Paneque, D., Pantaleo, F. R., Paoletti, R., Paredes, J. M., Parmiggiani, N., Patel, S. R., Patricelli, B., Pavlović, D., Pech, M., Pecimotika, M., Pensec, U., Peresano, M., Pérez-Romero, J., Peron, G., Persic, M., Petrucci, P. -O., Petruk, O., Piano, G., Pierre, E., Pietropaolo, E., Pintore, F., Pirola, G., Pita, S., Plard, C., Podobnik, F., Pohl, M., Polo, M., Pons, E., Ponti, G., Prandini, E., Prast, J., Principe, G., Priyadarshi, C., Produit, N., Pueschel, E., Pühlhofer, G., Pumo, M. L., Punch, M., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Recchia, S., Regeard, M., Reichherzer, P., Reimer, A., Reimer, O., Reisenegger, A., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Righi, C., Riitano, L., Rizi, V., Roache, E., Fernandez, G. Rodriguez, Rodríguez-Vázquez, J. J., Romano, P., Romeo, G., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Rulten, C. B., Russo, F., Sadeh, I., Saha, L., Saito, T., Salzmann, H., Sanchez, D., Sánchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santangelo, A., Santos-Lima, R., Sanuy, A., Šarić, T., Sarkar, A., Sarkar, S., Satalecka, K., Saturni, F. G., Savchenko, V., Scherer, A., Schipani, P., Schleicher, B., Schubert, J. L., Schussler, F., Schwanke, U., Schwefer, G., Arroyo, M. Seglar, Seiji, S., Semikoz, D., Sergijenko, O., Servillat, M., Sguera, V., Shang, R. Y., Sharma, P., Siejkowski, H., Sinha, A., Siqueira, C., Sliusar, V., Slowikowska, A., Sol, H., Specovius, A., Spencer, S. T., Spiga, D., Stamerra, A., Stanič, S., Starecki, T., Starling, R., Stawarz, Ł., Steppa, C., Stolarczyk, T., Strišković, J., Suda, Y., Suomijärvi, T., Tajima, H., Tak, D., Takahashi, M., Takeishi, R., Tanaka, S. J., Tavernier, T., Tejedor, L. A., Terauchi, K., Terrier, R., Teshima, M., Tian, W. W., Tibaldo, L., Tibolla, O., Torradeflot, F., Torres, D. F., Torresi, E., Tosti, G., Tosti, L., Tothill, N., Toussenel, F., Touzard, V., Tramacere, A., Travnicek, P., Tripodo, G., Truzzi, S., Tsiahina, A., Tutone, A., Vacula, M., Vallage, B., Vallania, P., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Verna, G., Viana, A., Viaux, N., Vigliano, A., Vigorito, C. F., Vitale, V., Vodeb, V., Voisin, V., Vorobiov, S., Voutsinas, G., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Wechakama, M., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wohlleben, F., Wolter, A., Yamamoto, T., Yamazaki, R., Yoshida, T., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zavrtanik, D., Zavrtanik, M., Zdziarski, A. A., Zech, A., Zhdanov, V. I., Živec, M., Zuriaga-Puig, J., and Luque, P. De la Torre
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Phenomenology - Abstract
Galaxy clusters are expected to be dark matter (DM) reservoirs and storage rooms for the cosmic-ray protons (CRp) that accumulate along the cluster's formation history. Accordingly, they are excellent targets to search for signals of DM annihilation and decay at gamma-ray energies and are predicted to be sources of large-scale gamma-ray emission due to hadronic interactions in the intracluster medium. We estimate the sensitivity of the Cherenkov Telescope Array (CTA) to detect diffuse gamma-ray emission from the Perseus galaxy cluster. We perform a detailed spatial and spectral modelling of the expected signal for the DM and the CRp components. For each, we compute the expected CTA sensitivity. The observing strategy of Perseus is also discussed. In the absence of a diffuse signal (non-detection), CTA should constrain the CRp to thermal energy ratio within the radius $R_{500}$ down to about $X_{500}<3\times 10^{-3}$, for a spatial CRp distribution that follows the thermal gas and a CRp spectral index $\alpha_{\rm CRp}=2.3$. Under the optimistic assumption of a pure hadronic origin of the Perseus radio mini-halo and depending on the assumed magnetic field profile, CTA should measure $\alpha_{\rm CRp}$ down to about $\Delta\alpha_{\rm CRp}\simeq 0.1$ and the CRp spatial distribution with 10% precision. Regarding DM, CTA should improve the current ground-based gamma-ray DM limits from clusters observations on the velocity-averaged annihilation cross-section by a factor of up to $\sim 5$, depending on the modelling of DM halo substructure. In the case of decay of DM particles, CTA will explore a new region of the parameter space, reaching models with $\tau_{\chi}>10^{27}$s for DM masses above 1 TeV. These constraints will provide unprecedented sensitivity to the physics of both CRp acceleration and transport at cluster scale and to TeV DM particle models, especially in the decay scenario., Comment: 93 pages (including author list, appendix and references), 143 figures. Submitted to JCAP
- Published
- 2023
- Full Text
- View/download PDF
21. Sounds as taxonomic indicators in Holocentrid fishes
- Author
-
Marine Banse, Estelle Bertimes, David Lecchini, Terry J. Donaldson, Frédéric Bertucci, and Eric Parmentier
- Subjects
General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Abstract The species-specific character of sounds in the animal kingdom has been extensively documented, yet research on fishes has predominantly focused on a limited number of species, overlooking the potential of acoustic signals to reflect broader taxonomic ranks. In this study, we analyzed acoustic data of hand-held sounds from 388 specimens spanning 5 genera and 33 species within the family Holocentridae, with the objective of evaluating the use of sound characteristics for taxonomic discrimination across various levels (subfamily, genus, species). Sounds could be indicative of grouping. Taxa discriminability depends on taxonomic level; the higher the taxonomic level, the better the discrimination of taxa based on sounds. Analogous to the role of morphological traits in taxonomic delineation, this research corroborates the utility of acoustic features in identifying fish taxa across multiple hierarchical levels. Remarkably, certain holocentrid species have evolved complex sound patterns characterized by unique temporal arrangements where pulses are not continuous but emitted in blocks, facilitating the exploitation of the acoustic space.
- Published
- 2024
- Full Text
- View/download PDF
22. Whole-exome profiles of inflammatory breast cancer and pathological response to neoadjuvant chemotherapy
- Author
-
François Bertucci, Arnaud Guille, Florence Lerebours, Michele Ceccarelli, Najeeb Syed, José Adélaïde, Pascal Finetti, Naoto T. Ueno, Steven Van Laere, Patrice Viens, Alexandre De Nonneville, Anthony Goncalves, Daniel Birnbaum, Céline Callens, Davide Bedognetti, and Emilie Mamessier
- Subjects
Inflammatory breast cancer ,Copy number alteration ,Mutation ,Whole-exome sequencing ,Medicine - Abstract
Abstract Background Neoadjuvant chemotherapy (NACT) became a standard treatment strategy for patients with inflammatory breast cancer (IBC) because of high disease aggressiveness. However, given the heterogeneity of IBC, no molecular feature reliably predicts the response to chemotherapy. Whole-exome sequencing (WES) of clinical tumor samples provides an opportunity to identify genomic alterations associated with chemosensitivity. Methods We retrospectively applied WES to 44 untreated IBC primary tumor samples and matched normal DNA. The pathological response to NACT, assessed on operative specimen, distinguished the patients with versus without pathological complete response (pCR versus no-pCR respectively). We compared the mutational profiles, spectra and signatures, pathway mutations, copy number alterations (CNAs), HRD, and heterogeneity scores between pCR versus no-pCR patients. Results The TMB, HRD, and mutational spectra were not different between the complete (N = 13) versus non-complete (N = 31) responders. The two most frequently mutated genes were TP53 and PIK3CA. They were more frequently mutated in the complete responders, but the difference was not significant. Only two genes, NLRP3 and SLC9B1, were significantly more frequently mutated in the complete responders (23% vs. 0%). By contrast, several biological pathways involved in protein translation, PI3K pathway, and signal transduction showed significantly higher mutation frequency in the patients with pCR. We observed a higher abundance of COSMIC signature 7 (due to ultraviolet light exposure) in tumors from complete responders. The comparison of CNAs of the 3808 genes included in the GISTIC regions between both patients’ groups identified 234 genes as differentially altered. The CIN signatures were not differentially represented between the complete versus non-complete responders. Based on the H-index, the patients with heterogeneous tumors displayed a lower pCR rate (11%) than those with less heterogeneous tumors (35%). Conclusions This is the first study aiming at identifying correlations between the WES data of IBC samples and the achievement of pCR to NACT. Our results, obtained in this 44-sample series, suggest a few subtle genomic alterations associated with pathological response. Additional investigations are required in larger series.
- Published
- 2024
- Full Text
- View/download PDF
23. Endometrioid ovarian carcinoma landscape: pathological and molecular characterization
- Author
-
Alexandre deNonneville, Elsa Kalbacher, Francesco Cannone, Arnaud Guille, José Adelaïde, Pascal Finetti, Maria Cappiello, Eric Lambaudie, Giuseppe Ettore, Emmanuelle Charafe, Emilie Mamessier, Magali Provansal, François Bertucci, and Renaud Sabatier
- Subjects
endometrioid carcinoma ,gene expression profiling ,genomic ,ovarian cancer ,tissue microarray ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Endometrioid ovarian cancers (EOvC) are usually managed as serous tumors. In this study, we conducted a comprehensive molecular investigation to uncover the distinct biological characteristics of EOvC. This retrospective multicenter study involved patients from three European centers. We collected clinical data and formalin‐fixed paraffin‐embedded (FFPE) samples for analysis at the DNA level using panel‐based next‐generation sequencing and array‐comparative genomic hybridization. Additionally, we examined mRNA expression using NanoString nCounter® and protein expression through tissue microarray. We compared EOvC with other ovarian subtypes and uterine endometrioid tumors. Furthermore, we assessed the impact of molecular alterations on patient outcomes, including progression‐free survival (PFS) and overall survival (OS). Preliminary analysis of clinical data from 668 patients, including 86 (12.9%) EOvC, revealed more favorable prognosis for EOvC compared with serous ovarian carcinoma (5‐year OS of 60% versus 45%; P = 0.001) driven by diagnosis at an earlier stage. Immunohistochemistry and copy number alteration (CNA) profiles of 43 cases with clinical data and FFPE samples available indicated that EOvC protein expression and CNA profiles were more similar to endometrioid endometrial tumors than to serous ovarian carcinomas. EOvC exhibited specific alterations, such as lower rates of PTEN loss, mutations in DNA repair genes, and P53 abnormalities. Survival analysis showed that patients with tumors harboring loss of PTEN expression had worse outcomes (median PFS 19.6 months vs. not reached; P = 0.034). Gene expression profile analysis confirmed that EOvC differed from serous tumors. However, comparison to other rare subtypes of ovarian cancer suggested that the EOvC transcriptomic profile was close to that of ovarian clear cell carcinoma. Downregulation of genes involved in the PI3K pathway and DNA methylation was observed in EOvC. In conclusion, EOvC represents a distinct biological entity and should be regarded as such in the development of specific clinical approaches.
- Published
- 2024
- Full Text
- View/download PDF
24. Stochastic optimal transport and Hamilton-Jacobi-Bellman equations on the set of probability measures
- Author
-
Bertucci, Charles
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Optimization and Control ,Mathematics - Probability - Abstract
We introduce a stochastic version of the optimal transport problem. We provide an analysis by means of the study of the associated Hamilton-Jacobi-Bellman equation, which is set on the set of probability measures. We introduce a new definition of viscosity solutions of this equation, which yields general comparison principles, in particular for cases involving terms modeling stochasticity in the optimal control problem. We are then able to establish results of existence and uniqueness of viscosity solutions of the Hamilton-Jacobi-Bellman equation. These results rely on controllability results for stochastic optimal transport that we also establish.
- Published
- 2023
25. Sounds as taxonomic indicators in Holocentrid fishes
- Author
-
Banse, Marine, Bertimes, Estelle, Lecchini, David, Donaldson, Terry J., Bertucci, Frédéric, and Parmentier, Eric
- Published
- 2024
- Full Text
- View/download PDF
26. Whole-exome profiles of inflammatory breast cancer and pathological response to neoadjuvant chemotherapy
- Author
-
Bertucci, François, Guille, Arnaud, Lerebours, Florence, Ceccarelli, Michele, Syed, Najeeb, Adélaïde, José, Finetti, Pascal, Ueno, Naoto T., Van Laere, Steven, Viens, Patrice, De Nonneville, Alexandre, Goncalves, Anthony, Birnbaum, Daniel, Callens, Céline, Bedognetti, Davide, and Mamessier, Emilie
- Published
- 2024
- Full Text
- View/download PDF
27. Altered ribosomal profile in acquired resistance and reversal associates with pathological response to chemotherapy in inflammatory breast cancer
- Author
-
Devi, Gayathri R., Pai, Pritha, Lee, Seayoung, Foster, Matthew W., Sannareddy, Dorababu S., Bertucci, Francois, Ueno, Naoto, and Van Laere, Steven
- Published
- 2024
- Full Text
- View/download PDF
28. Mutational landscape of inflammatory breast cancer
- Author
-
Bertucci, François, Lerebours, Florence, Ceccarelli, Michele, Guille, Arnaud, Syed, Najeeb, Finetti, Pascal, Adélaïde, José, Van Laere, Steven, Goncalves, Anthony, Viens, Patrice, Birnbaum, Daniel, Mamessier, Emilie, Callens, Céline, and Bedognetti, Davide
- Published
- 2024
- Full Text
- View/download PDF
29. Macrophages reprogramming driven by cancer-associated fibroblasts under FOLFIRINOX treatment correlates with shorter survival in pancreatic cancer
- Author
-
Hussain, Zainab, Bertran, Thomas, Finetti, Pascal, Lohmann, Eugenie, Mamessier, Emilie, Bidaut, Ghislain, Bertucci, François, Rego, Moacyr, and Tomasini, Richard
- Published
- 2024
- Full Text
- View/download PDF
30. Erosion vs. accretion of sandy beaches: their impacts on nursery areas of coral reef fish
- Author
-
Lecchini, David, Tessonneau, Julien, Dulornne, Maguy, Gairin, Emma, Roux, Natacha, Waqalevu, Viliame, Vignaud, Léa, Minier, Lana, Beaufort, Océane, James, Dorothée, Trouillefou, Malika, Dromard, Charlotte. R., and Bertucci, Frédéric
- Published
- 2024
- Full Text
- View/download PDF
31. Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities
- Author
-
Jiang, Yi-Zhou, Ma, Ding, Jin, Xi, Xiao, Yi, Yu, Ying, Shi, Jinxiu, Zhou, Yi-Fan, Fu, Tong, Lin, Cai-Jin, Dai, Lei-Jie, Liu, Cheng-Lin, Zhao, Shen, Su, Guan-Hua, Hou, Wanwan, Liu, Yaqing, Chen, Qingwang, Yang, Jingcheng, Zhang, Naixin, Zhang, Wen-Juan, Liu, Wei, Ge, Weigang, Yang, Wen-Tao, You, Chao, Gu, Yajia, Kaklamani, Virginia, Bertucci, François, Verschraegen, Claire, Daemen, Anneleen, Shah, Nakul M., Wang, Ting, Guo, Tiannan, Shi, Leming, Perou, Charles M., Zheng, Yuanting, Huang, Wei, and Shao, Zhi-Ming
- Published
- 2024
- Full Text
- View/download PDF
32. Sensitivity of the Cherenkov Telescope Array to spectral signatures of hadronic PeVatrons with application to Galactic Supernova Remnants
- Author
-
Consortium, The Cherenkov Telescope Array, Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Aloisio, R., Crespo, N. Álvarez, Batista, R. Alves, Amati, L., Amato, E., Ambrosi, G., Angüner, E. O., Aramo, C., Arcaro, C., Armstrong, T., Asano, K., Ascasibar, Y., Aschersleben, J., Backes, M., Baktash, A., Balazs, C., Balbo, M., Ballet, J., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Baxter, J. R., Tjus, J. Becker, Benbow, W., Bernardos-Martín, M. I., Bernete, J., Berti, A., Bertucci, B., Beshley, V., Bhattacharjee, P., Bhattacharyya, S., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Bordas, P., Bottacini, E., Bregeon, J., Brose, R., Bucciantini, N., Bulgarelli, A., Capasso, M., Dolcetta, R. A. Capuzzo, Caraveo, P., Cardillo, M., Carosi, R., Casanova, S., Cascone, E., Cassol, F., Catalani, F., Cerruti, M., Chadwick, P., Chaty, S., Chen, A., Chernyakova, M., Chiavassa, A., Chudoba, J., Coimbra-Araujo, C., Conforti, V., Contreras, J. L., Costa, A., Costantini, H., Cristofari, P., Crocker, R., D'Amico, G., D'Ammando, F., De Angelis, A., De Caprio, V., Pino, E. M. de Gouveia Dal, Wilhelmi, E. de Ona, de Souza, V., Delgado, C., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Pierro, F., Di Tria, R., Di Venere, L., Diebold, S., Djuvsland, J. I., Donini, A., Doro, M., Anjos, R. d. C. Dos, Dwarkadas, V. V., Einecke, S., Elsässer, D., Emery, G., Evoli, C., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Ferrand, G., Fiandrini, E., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Fontaine, G., Fukami, S., Galanti, G., Galaz, G., Gammaldi, V., Gasbarra, C., Ghalumyan, A., Ghirlanda, G., Giarrusso, M., Giavitto, G., Giglietto, N., Giordano, F., Giroletti, M., Giuliani, A., Giunti, L., Godinovic, N., Coelho, J. Goulart, Gréaux, L., Green, D., Grondin, M-H., Gueta, O., Gunji, S., Hassan, T., Heller, M., Hernández-Cadena, S., Hinton, J., Hnatyk, B., Hnatyk, R., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hrabovsky, M., Hrupec, D., Inada, T., Incardona, F., Inoue, S., Ishio, K., Jamrozy, M., Janecek, P., Martínez, I. Jiménez, Jin, W., Jung-Richardt, I., Jurysek, J., Kaaret, P., Karas, V., Katz, U., Kerszberg, D., Khélifi, B., Kieda, D. B., Kissmann, R., Kleiner, T., Kluge, G., Kluzniak, W., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kubo, H., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leto, G., Leuschner, F., Lindfors, E., Liodakis, I., Lohse, T., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Luque-Escamilla, P. L., Macias, O., Mackey, J., Majumdar, P., Mandat, D., Manganaro, M., Manicò, G., Marconi, M., Martí, J., Martínez, G., Martinez, M., Martinez, O., Mello, A. J. T. S., Menchiari, S., Meyer, D. M. -A., Micanovic, S., Miceli, D., Miceli, M., Michalowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Montaruli, T., Morcuende, D., Morlino, G., Morselli, A., Mosè, M., Moulin, E., Mukherjee, R., Munari, K., Murach, T., Nagai, A., Nagataki, S., Nemmen, R., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikolajuk, M., Nishijima, K., Noda, K., Novosyadlyj, B., Nozaki, S., Ohishi, M., Ohm, S., Ohtani, Y., Okumura, A., Olmi, B., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Orlando, S., Ostrowski, M., Oya, I., Pantaleo, F. R., Paredes, J. M., Patricelli, B., Pecimotika, M., Peresano, M., Pérez-Romero, J., Persic, M., Petruk, O., Piano, G., Pietropaolo, E., Pirola, G., Pittori, C., Pohl, M., Ponti, G., Prandini, E., Principe, G., Priyadarshi, C., Pueschel, E., Pühlhofer, G., Pumo, M. L., Quirrenbach, A., Rando, R., Razzaque, S., Reichherzer, P., Reimer, A., Reimer, O., Renaud, M., Reposeur, T., Ribó, M., Richtler, T., Rico, J., Rieger, F., Rigoselli, M., Riitano, L., Rizi, V., Roache, E., Romano, P., Romeo, G., Rosado, J., Rowell, G., Rudak, B., Sadeh, I., Safi-Harb, S., Saha, L., Sailer, S., Sánchez-Conde, M., Sarkar, S., Satalecka, K., Saturni, F. G., Scherer, A., Schovánek, P., Schussler, F., Schwanke, U., Scuderi, S., Seglar-Arroyo, M., Sergijenko, O., Servillat, M., Shang, R-Y., Sharma, P., Siejkowski, H., Sliusar, V., Słowikowska, A., Sol, H., Specovius, A., Spencer, S. T., Spengler, G., Stamerra, A., Stanič, S., Starecki, T., Starling, R., Stolarczyk, T., Pereira, L. A. Stuani, Suda, Y., Suomijarvi, T., Sushch, I., Tajima, H., Tam, P-H. T., Tanaka, S. J., Tavecchio, F., Testa, V., Tian, W., Tibaldo, L., Torres, D. F., Tothill, N., Vallage, B., Vallania, P., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Acosta, M. Vazquez, Vecchi, M., Vercellone, S., Verna, G., Viana, A., Vignatti, J., Vitale, V., Vodeb, V., Vorobiov, S., Vuillaume, T., Wagner, S. J., Walter, R., White, M., Wierzcholska, A., Will, M., Williams, D., Yang, L., Yoshida, T., Yoshikoshi, T., Zaharijas, G., Zampieri, L., Zavrtanik, D., Zavrtanik, M., Zhdanov, V. I., and Živec, M.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The local Cosmic Ray (CR) energy spectrum exhibits a spectral softening at energies around 3~PeV. Sources which are capable of accelerating hadrons to such energies are called hadronic PeVatrons. However, hadronic PeVatrons have not yet been firmly identified within the Galaxy. Several source classes, including Galactic Supernova Remnants (SNRs), have been proposed as PeVatron candidates. The potential to search for hadronic PeVatrons with the Cherenkov Telescope Array (CTA) is assessed. The focus is on the usage of very high energy $\gamma$-ray spectral signatures for the identification of PeVatrons. Assuming that SNRs can accelerate CRs up to knee energies, the number of Galactic SNRs which can be identified as PeVatrons with CTA is estimated within a model for the evolution of SNRs. Additionally, the potential of a follow-up observation strategy under moonlight conditions for PeVatron searches is investigated. Statistical methods for the identification of PeVatrons are introduced, and realistic Monte--Carlo simulations of the response of the CTA observatory to the emission spectra from hadronic PeVatrons are performed. Based on simulations of a simplified model for the evolution for SNRs, the detection of a $\gamma$-ray signal from in average 9 Galactic PeVatron SNRs is expected to result from the scan of the Galactic plane with CTA after 10 hours of exposure. CTA is also shown to have excellent potential to confirm these sources as PeVatrons in deep observations with $\mathcal{O}(100)$ hours of exposure per source., Comment: 34 pages, 16 figures, Accepted for publication in Astroparticle Physics
- Published
- 2023
- Full Text
- View/download PDF
33. Data driven analysis of cosmic rays in the heliosphere: diffusion of cosmic protons
- Author
-
Tomassetti, N., Fiandrini, E., Bertucci, B., Donnini, F., Graziani, M., Khiali, B., and Conde, A. Reina
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
Understanding the time-dependent relationship between the Sun's variability and cosmic rays (GCR) is essential for developing predictive models of energetic radiation in space. When traveling inside the heliosphere, GCRs are affected by magnetic turbulence and solar wind disturbances which result in the so-called solar modulation effect. To investigate this phenomenon, we have performed a data-driven analysis of the temporal dependence of the GCR flux over the solar cycle. With a global statistical inference of GCR data collected in space by AMS-02 and PAMELA on monthly basis, we have determined the rigidity and time dependence of the GCR diffusion mean free path. Here we present our results for GCR protons, we discuss their interpretation in terms of basic processes of particle transport and their relations with the dynamics of the heliospheric plasma., Comment: 5 pages, 4 figures, comments welcome
- Published
- 2023
- Full Text
- View/download PDF
34. Altered ribosomal profile in acquired resistance and reversal associates with pathological response to chemotherapy in inflammatory breast cancer
- Author
-
Gayathri R. Devi, Pritha Pai, Seayoung Lee, Matthew W. Foster, Dorababu S. Sannareddy, Francois Bertucci, Naoto Ueno, and Steven Van Laere
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Therapeutic resistance presents a significant hurdle in combating inflammatory breast cancer (IBC), adding to the complexity of its management. To investigate these mechanisms, we conducted a comprehensive analysis using transcriptomic and proteomic profiling in a preclinical model alone with correlates of treatment response in IBC patients. This included SUM149 cell lines derived from treatment-naïve patients, along with acquired drug resistance (rSUM149) and others in a state of resistance reversal (rrSUM149), aiming to uncover drug resistance networks. We identified specific ribosomal proteins associated with acquiring resistance. These correlated with elevated levels of molecular markers such as pERK, CDK1, XIAP, and SOD2. While resistance reversal in rrSUM149 cells largely normalized the expression profile, VIPER analysis revealed persistent alterations in ribosomal process-related proteins (AGO2, Exportin 1, RPL5), suggesting their continued involvement in drug resistance. Moreover, genes linked to ribosomal processes were significantly enriched (P
- Published
- 2024
- Full Text
- View/download PDF
35. On Lipschitz solutions of mean field games master equations
- Author
-
Bertucci, Charles, Lasry, Jean-Michel, and Lions, Pierre-Louis
- Subjects
Mathematics - Analysis of PDEs - Abstract
We develop a theory of existence and uniqueness of solutions of MFG master equations when the initial condition is Lipschitz continuous. Namely, we show that as long as the solution of the master equation is Lipschitz continuous in space, it is uniquely defined. Because we do not impose any structural assumptions, such as monotonicity for instance, there is a maximal time of existence for the notion of solution we provide. We analyze three cases: the case of a finite state space, the case of master equation set on a Hilbert space, and finally on the set of probability measures, all in cases involving common noises. In the last case, the Lipschitz continuity we refer to is on the gradient of the value function with respect to the state variable of the player.
- Published
- 2023
36. Zeno: An Interactive Framework for Behavioral Evaluation of Machine Learning
- Author
-
Cabrera, Ángel Alexander, Fu, Erica, Bertucci, Donald, Holstein, Kenneth, Talwalkar, Ameet, Hong, Jason I., and Perer, Adam
- Subjects
Computer Science - Human-Computer Interaction - Abstract
Machine learning models with high accuracy on test data can still produce systematic failures, such as harmful biases and safety issues, when deployed in the real world. To detect and mitigate such failures, practitioners run behavioral evaluation of their models, checking model outputs for specific types of inputs. Behavioral evaluation is important but challenging, requiring that practitioners discover real-world patterns and validate systematic failures. We conducted 18 semi-structured interviews with ML practitioners to better understand the challenges of behavioral evaluation and found that it is a collaborative, use-case-first process that is not adequately supported by existing task- and domain-specific tools. Using these findings, we designed Zeno, a general-purpose framework for visualizing and testing AI systems across diverse use cases. In four case studies with participants using Zeno on real-world models, we found that practitioners were able to reproduce previous manual analyses and discover new systematic failures.
- Published
- 2023
- Full Text
- View/download PDF
37. Resistance to cosmetic botulinum toxin A: A 15-patient case series across 12 sites
- Author
-
Carlos G. Wambier, MD, PhD, Fatima N. Mirza, MD, MPH, Sarah P.F. Wambier, MD, PhD, Vince Bertucci, MD, Jean Carruthers, MD, Joely Kaufman, MD, John Martin, MD, J. Barton Sterling, MD, Flávia Brasileiro, MD, Carolina Marçon, MD, MSc, Allison J. Brown, MD, Miranda Rosenberg, MD, Lilia R.S. Guadanhim, MD, PhD, and Doris Hexsel, MD
- Subjects
botox ,botulinum toxin A ,botulinum toxin B ,cosmetic dermatology ,neuromodulator ,neurotoxin ,Dermatology ,RL1-803 - Published
- 2025
- Full Text
- View/download PDF
38. Automated Market Makers: Mean-Variance Analysis of LPs Payoffs and Design of Pricing Functions
- Author
-
Bergault, Philippe, Bertucci, Louis, Bouba, David, and Guéant, Olivier
- Subjects
Quantitative Finance - Trading and Market Microstructure - Abstract
With the emergence of decentralized finance, new trading mechanisms called Automated Market Makers have appeared. The most popular Automated Market Makers are Constant Function Market Makers. They have been studied both theoretically and empirically. In particular, the concept of impermanent loss has emerged and explains part of the profit and loss of liquidity providers in Constant Function Market Makers. In this paper, we propose another mechanism in which price discovery does not solely rely on liquidity takers but also on an external exchange rate or price oracle. We also propose to compare the different mechanisms from the point of view of liquidity providers by using a mean / variance analysis of their profit and loss compared to that of agents holding assets outside of Automated Market Makers. In particular, inspired by Markowitz' modern portfolio theory, we manage to obtain an efficient frontier for the performance of liquidity providers in the idealized case of a perfect oracle. Beyond that idealized case, we show that even when the oracle is lagged and in the presence of adverse selection by liquidity takers and systematic arbitrageurs, optimized oracle-based mechanisms perform better than popular Constant Function Market Makers.
- Published
- 2022
39. EP-283 - LEISHMANIOSE CUTÂNEA DIFUSA COMO DIAGNÓSTICO DIFERENCIAL DE ERITEMA NODOSO HANSÊNICO: RELATO DE CASO NO MATO GROSSO DO SUL
- Author
-
Sara Naomi Shimabukuro, Alexandre Albuquerque Bertucci, and Caroline Franciscato
- Subjects
Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Introdução: A leishmaniose cutânea difusa (LCD) é uma das formas de apresentação da leishmaniose tegumentar e um dos principais diagnósticos diferenciais a ser considerado é a hanseníase virchowiana (BRASIL, 2006). A resposta ao tratamento da LCD pode ser baixa e as recidivas são recorrentes (BRASIL, 2017). Objetivo: O trabalho visa ressaltar a possibilidade da afecção simultânea de LCD e hanseníase. Método: A metodologia consiste na descrição de um caso de LCD concomitante ao Eritema Nodoso Hansênico (ENH). Resultados: Homem, 37 anos, procedente do município de Bela Vista, Mato Grosso do Sul (MS), procurou o serviço de saúde no município de Campo Grande/MS em março de 2023 com queixas de lesões cutâneas em membros superiores, inferiores, icterícia, febre, diarreia e prostração há 01 mês. Contemplava em seu histórico o tratamento para hanseníase dimorfa com poliquimioterapia finalizado em 2019 e ENH em uso de talidomida com uso prévio recorrente de corticoides. Ao exame físico apresentava lesões crostosas ulceradas com base eritematosa de distribuição randômica, hepatoesplenomegalia sem alterações ao exame pulmonar e cardíaco. Os exames laboratoriais iniciais evidenciavam pancitopenia, disfunção hepática, renal e sorologias negativas para sífilis, hepatites B e C, HIV e dengue, zika e chigungunya. Considerando o quadro clínico, foi solicitado exame sorológico para leishmaniose visceral com resultado reagente de imunofluorescência direta com título 1:80 e pesquisa de amastigotas em aspirado medula óssea negativo. Realizado biópsia excisional de lesões de membros superior e inferior esquerdo com pesquisa de amastigotas positiva. Foi tratado com anfotericina B Lipossomal na dose cumulativa total de 30 mg/kg. Após o tratamento evoluiu com melhora clínica e laboratorial com regressão e reepitelização das lesões, não havendo, até o momento, recidiva. Conclusão: A LCD pode se manifestar em indivíduos que apresentem anergia e deficiência específica na resposta imune celular a antígenos de Leishmania sp. O quadro clínico caracteriza-se por lesões de evolução insidiosa até o desenvolvimento de placas e nodulações não ulceradas em grandes extensões cutâneas (BRASIL, 2017). Torrealba (1994) descreve um caso de coinfecção na Venezuela com as formas hanseníase virchowiana e leishmaniose cutânea localizada com boa evolução após o tratamento com meglumina. Deste modo, além da análise de diagnósticos diferenciais, é de suma importância considerar a possibilidade da afecção em concomitância das patologias.
- Published
- 2024
- Full Text
- View/download PDF
40. EP-395 - HISTOPLASMOSE DISSEMINADA E TUBERCULOSE EM PESSOA VIVENDO COM AIDS: RELATO DE CASO
- Author
-
Adriana Vieira Souza, Alexandre Albuquerqu Bertucci, and Caroline Franciscato
- Subjects
Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Introdução: A histoplasmose é uma micose sistêmica, causada pelo fungo dimórfico Histoplasma capsulatum (HC), altamente endêmico na América do Sul (PAHO, 2020). Objetivo: Este trabalho se propõe a descrever um caso de histoplasmose disseminada com posterior coinfecção por tuberculose (TB) disseminada em pacientes com AIDS. Resultados: Homem, 35 anos, natural e procedente de Cassilândia, com diagnóstico de HIV, sendo a última carga viral de 2010 cópias/mL e contagem de linfócitos TCD4 de 15 céls/mm³. Apresentava pápulas eritematosas em couro cabeludo, tórax, abdome, membros superiores, dorso, nádegas e região perianal há cinco meses. Seu histórico patológico também incluía sarcoma de Kaposi (SK) com acometimento linfático em membro inferior direito, múltiplas perdas de seguimento e TB com diagnóstico clínico/epidemiológico. Realizou biópsias de lesões perianais e da região torácica com crescimento de HC em ambas. Sua tomografia de tórax evidenciava opacidades nodulares com atenuação em vidro fosco bilateralmente. Em análise de escarro, além de pesquisas negativas para tuberculose, também houve crescimento de HC. Foi inicialmente tratado com anfotericina B complexo lipídico (5mg/Kg/dia) por 12 dias e, posteriormente, intraconazol 600 mg/dia de acordo com melhora clínica do paciente. Após primeiro ano de seu acompanhamento, paciente apresentou resultado detectável para TRM-TB em escarro, com sensibilidade à rifampicina, e LF-LAM em urina positiva, iniciado tratamento para tuberculose disseminada. Após perda de seguimento, retornou em tratamento irregular de tuberculose e do HIV, porém, em tratamento quimioterápico para SK. Apresentava-se com piora de estado geral e manutenção de lesões perianais com sintomas de proctite. Optado por reintrodução de tratamento para TB e histoplasmose. Realizou nova biópsia de lesões perianais após dois meses, não sendo observadas novas estruturas sugestivas de histoplasmose. Segue em acompanhamento em serviço de infectologia de Campo Grande/MS, realizando manutenção de tratamento de histoplasmose com anfotericina B lipossomal 3 mg/kg/dia, mantendo boa evolução clínica e ausência de sinais de recidiva de histoplasmose. Conclusão: A histoplasmose disseminada em áreas endêmicas pode ser confundida com tuberculose (Almeida et al, 2019). Em revisão sistemática, Almeida et al, observou simultaneidade de diagnósticos em 10,37% dos casos em estudos brasileiros, logo, é necessário manter a investigação para tuberculose mesmo em vigência de critérios para histoplasmose disseminada.
- Published
- 2024
- Full Text
- View/download PDF
41. Joint Optimization of Charging Infrastructure Placement and Operational Schedules for a Fleet of Battery Electric Trucks.
- Author
-
Juan Pablo Bertucci, Theo Hofman, and Mauro Salazar
- Published
- 2024
- Full Text
- View/download PDF
42. Comparison of Multivariate Linear and Nonlinear Models for FES Cycling
- Author
-
Henrique e Silva Bezerra, Bruno, Henrique Bertucci Borges, Luiz, Delisle-Rodriguez, Denis, de Sousa Britto, Heloísa Maria Jácome, de Oliveira Dantas, André Felipe Azevêdo, do Espirito Santo, Caroline Cunha, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Marques, Jefferson Luiz Brum, editor, Rodrigues, Cesar Ramos, editor, Suzuki, Daniela Ota Hisayasu, editor, Marino Neto, José, editor, and García Ojeda, Renato, editor
- Published
- 2024
- Full Text
- View/download PDF
43. Cycling Lower-Limb Movement Analysis and Decoding by LSTM for a Motor Imagery-Based FES Rehabilitation System—A SCI Patient Case Study
- Author
-
Bertucci, Luiz Henrique, do Espirito Santo, Caroline Cunha, Spinelli, Bruno Guedes, Rodrigues, Abner Cardoso, de Oliveira Dantas, André Felipe Azevedo, Delisle-Rodriguez, Denis, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Marques, Jefferson Luiz Brum, editor, Rodrigues, Cesar Ramos, editor, Suzuki, Daniela Ota Hisayasu, editor, Marino Neto, José, editor, and García Ojeda, Renato, editor
- Published
- 2024
- Full Text
- View/download PDF
44. An integrated tumor, immune and microbiome atlas of colon cancer.
- Author
-
Roelands, Jessica, Kuppen, Peter, Ahmed, Eiman, Mall, Raghvendra, Masoodi, Tariq, Singh, Parul, Monaco, Gianni, Raynaud, Christophe, de Miranda, Noel, Ferraro, Luigi, Carneiro-Lobo, Tatiana, Syed, Najeeb, Rawat, Arun, Awad, Amany, Decock, Julie, Mifsud, William, Miller, Lance, Sherif, Shimaa, Mohamed, Mahmoud, Rinchai, Darawan, Van den Eynde, Marc, Sayaman, Rosalyn, Ziv, Elad, Bertucci, Francois, Petkar, Mahir, Lorenz, Stephan, Mathew, Lisa, Wang, Kun, Murugesan, Selvasankar, Chaussabel, Damien, Vahrmeijer, Alexander, Wang, Ena, Ceccarelli, Anna, Fakhro, Khalid, Zoppoli, Gabriele, Ballestrero, Alberto, Tollenaar, Rob, Marincola, Francesco, Galon, Jérôme, Khodor, Souhaila, Ceccarelli, Michele, Hendrickx, Wouter, and Bedognetti, Davide
- Subjects
Humans ,Cohort Studies ,Biomarkers ,Tumor ,Colonic Neoplasms ,Transcriptome ,Tumor Microenvironment - Abstract
The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, we performed comprehensive genomic analyses on fresh-frozen samples from 348 patients affected by primary colon cancer, encompassing RNA, whole-exome, deep T cell receptor and 16S bacterial rRNA gene sequencing on tumor and matched healthy colon tissue, complemented with tumor whole-genome sequencing for further microbiome characterization. A type 1 helper T cell, cytotoxic, gene expression signature, called Immunologic Constant of Rejection, captured the presence of clonally expanded, tumor-enriched T cell clones and outperformed conventional prognostic molecular biomarkers, such as the consensus molecular subtype and the microsatellite instability classifications. Quantification of genetic immunoediting, defined as a lower number of neoantigens than expected, further refined its prognostic value. We identified a microbiome signature, driven by Ruminococcus bromii, associated with a favorable outcome. By combining microbiome signature and Immunologic Constant of Rejection, we developed and validated a composite score (mICRoScore), which identifies a group of patients with excellent survival probability. The publicly available multi-omics dataset provides a resource for better understanding colon cancer biology that could facilitate the discovery of personalized therapeutic approaches.
- Published
- 2023
45. A mean field model for the development of renewable capacities
- Author
-
Alasseur, Clémence, Basei, Matteo, Bertucci, Charles, and Cecchin, Alekos
- Subjects
Mathematics - Optimization and Control ,91A16, 91B50, 49N80 - Abstract
We propose a model based on a large number of small competitive producers of renewable energies, to study the effect of subsidies on the aggregate level of capacity, taking into account a cannibalization effect. We first derive a model to explain how long-time equilibrium can be reached on the market of production of renewable electricity and compare this equilibrium to the case of monopoly. Then we consider the case in which other capacities of production adjust to the production of renewable energies. The analysis is based on a master equation and we get explicit formulae for the long-time equilibria. We also provide new numerical methods to simulate the master equation and the evolution of the capacities. Thus we find the optimal subsidies to be given by a central planner to the installation and the production in order to reach a desired equilibrium capacity., Comment: 21 pages, 8 figures
- Published
- 2022
46. New insights from cross-correlation studies between Solar activity and Cosmic-ray fluxes
- Author
-
Tomassetti, Nicola, Bertucci, Bruna, and Fiandrini, Emanuele
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Physics - Space Physics - Abstract
The observed variability of the cosmic-ray intensity in the interplanetary space is driven by the evolution of the Sun's magnetic activity over its 11-year quasiperiodical cycle. Investigating the relationship between solar activity indices and cosmic-ray intensity measurements is then essential for understanding the fundamental processes of particle transport in the heliosphere. Here we have performed a global characterization the solar modulation of cosmic rays over the solar activity cycle and for different energies of the cosmic particles. We present our cross-correlation studies using data from space experiments, neutron monitors and solar observatories collected over several solar cycles., Comment: 8 pages, 1 figure, proceedings of the ICRC-2021 conference
- Published
- 2022
- Full Text
- View/download PDF
47. Data driven analysis of Galactic cosmic rays in the heliosphere: diffusion of cosmic protons and nuclei
- Author
-
Tomassetti, Nicola, Bertucci, Bruna, Donnini, Federico, Fiandrini, Emanuele, Graziani, Maura, Khiali, Behrouz, and Conde, Alejandro Reina
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
Galactic cosmic rays (GCRs) inside the heliosphere are affected by magnetic turbulence and Solar wind disturbances which result in the so-called solar modulation effect. To investigate this phenomenon, we have performed a data-driven analysis of the temporal dependence of the GCR flux over the solar cycle. With a global statistical inference of GCR data collected in space by AMS-02, PAMELA, and CRIS on monthly basis, we have determined the dependence of the GCR diffusion parameters upon time and rigidity. In this conference, we present our results for GCR protons and nuclei, we discuss their interpretation in terms of basic processes of particle transport and their relations with the dynamics of the heliospheric plasma., Comment: 8 pages, 3 figures, proceedings of ICRC-2021 conference
- Published
- 2022
- Full Text
- View/download PDF
48. Temporal evolution and rigidity dependence of the solar modulation lag of Galactic cosmic rays
- Author
-
Tomassetti, Nicola, Bertucci, Bruna, and Fiandrini, Emanuele
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Physics - Space Physics - Abstract
When traveling in the heliosphere, Galactic cosmic rays (GCRs) are subjected to the solar modulation effect, a quasiperiodical change of their intensity caused by the 11-year cycle of solar activity. Here we investigate the association of solar activity and cosmic radiation over five solar cycles, from 1965 to 2020, using a collection of multichannel data from neutron monitors, space missions, and solar observatories. In particular, we focus on the time lag between the monthly sunspot number and the GCR flux variations. We show that the modulation lag is subjected to a 22-year periodical variation, ranging from about 2 to 14 months and following the polarity cycle of the Sun's magnetic field. We also show that the lag is remarkably decreasing with increasing energy of the GCR particles. These results reflect the interplay of basic physics phenomena that cause the GCR modulation effect: the drift motion of charged particles in the interplanetary magnetic field, the latitudinal dependence of the solar wind, the energy dependence of their residence time in the heliosphere. Based on this interpretation, we end up with a global effective formula for the modulation lag and testable predictions for the flux evolution of cosmic particles and antiparticles over the solar cycle., Comment: 13 pages, 9 figures and 2 tables, matches version published in PRD
- Published
- 2022
- Full Text
- View/download PDF
49. A singular infinite dimensional Hamilton-Jacobi-Bellman equation arising from a storage problem
- Author
-
Bertucci, Charles, Lasry, Jean-Michel, and Lions, Pierre Louis
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Optimization and Control - Abstract
In the first part of this paper, we derive an infinite dimensional partial differential equation which describes an economic equilibrium in a model of storage which includes an infinite number of non-atomic agents. This equation has the form of a mean field game master equation. The second part of the paper is devoted to the mathematical study of the Hamilton-Jacobi-Bellman equation from which the previous equation derives. This last equation is both singular and set on a Hilbert space and thus raises new mathematical difficulties.
- Published
- 2022
50. Regorafenib in patients with advanced Ewing sarcoma: results of a non-comparative, randomised, double-blind, placebo-controlled, multicentre Phase II study
- Author
-
Duffaud, Florence, Blay, Jean-Yves, Le Cesne, Axel, Chevreau, Christine, Boudou-Rouquette, Pascaline, Kalbacher, Elsa, Penel, Nicolas, Perrin, Christophe, Laurence, Valérie, Bompas, Emmanuelle, Saada-Bouzid, Esma, Delcambre, Corinne, Bertucci, François, Cancel, Mathilde, Schiffler, Camille, Monard, Laure, Bouvier, Corinne, Vidal, Vincent, Gaspar, Nathalie, and Chabaud, Sylvie
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.