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1,729 results on '"Bertone, C"'

24. HL-LHC IT STRING: Status and Perspectives

Author

Bajko, M., Baglin, V., Ballarino, A., Bednarek, M. J., Bertolasi, S., Bertone, C., Blanchard, S., Bozzini, D., Coulot, E., Coupat, C., Cruikshank, P., Dangelo, Giorgio, Dragoni, F., Fessia, P., Gascon, J. C., Girardot, G., Heredia Garcia, Nicolas, Herty, A., Kosmicki, A., Lees, A. J., e Naour, S., Nowak, E., Maan, W., Martinez Selles, Alejandro, Martino, M., Metselaar, J., Pojer, M., Otto, T., Rolando, G., Pelletier, S., Perin, A., Piednoir, D., Richards, E., Rodriguez Perez, Marta, Santos, N. Dos, Thiesen, H., Todesco, E., Yammine, S., Zerlauth, M., Zawilinski, J., Vergara Fernandez, Estrella, and Wollmann, D.

Abstract

The HL-LHC IT STRING, an integrated test stand for the major components of the HL-LHC Inner Triplet (IT) zone, is in its construction phase in a surface building at CERN. The main motivation is to study and validate the collective behavior of the different systems: magnets, circuit protection, cryogenics for magnets and superconducting link, magnet powering, vacuum, alignment, and interconnections between magnets and superconducting link. During the past two years, the major focus has been on the technical infrastructure definition and implementation, while preparing the installation sequences and procedures for the major elements. The String Validation Program (SVP) has been agreed with the HL-LHC Work Packages, allowing to set up a joint and optimized test program and to integrate it in a schedule. In this paper we describe the IT String installations and describe the main differences between the HL-LHC IT String and the future HL-LHC machine. The main line of the test program and the motivation of a full thermal cycle with a cost benefit analysis will be presented.

Published
2024
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25. Characteristics, Outcome and Prognostic Factors of Patients with Emergency Department Cardiac Arrest: A 14-Year Retrospective Study.

Author

Giamello JD, D'Agnano S, Paglietta G, Bertone C, Bruno A, Martini G, Poggi A, Sciolla A, and Lauria G

Abstract

Introduction : Cardiac arrests are traditionally classified according to the setting in which they occur, including out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA). However, cardiac arrests that occur in the emergency department (EDCA) could constitute a third category, due to the peculiar characteristics of the emergency department (ED). In recent years, the need to study EDCAs separately from other intra-hospital events has emerged. The aim of this study was to describe the characteristics and outcomes of a cohort of patients experiencing EDCA in an Italian hospital over a 14-year period. Methods : This was a single-centre retrospective observational study conducted in the ED of the Santa Croce e Carle Hospital in Cuneo, Italy. All adult patients who experienced EDCA between 1 January 2010 and 30 June 2023 were included. OHCA patients, those arriving in the ED with on-going resuscitation measures, patients with EDCA not undergoing resuscitation, and patients with post-traumatic cardiac arrest were excluded from the study. The main outcome of the study was survival at hospital discharge with a favourable neurological outcome. Results : 350 cases of EDCA were included. The median age was 78 (63-85) years, and the median Charlson Comorbidity Index score was 5 (3-6). A total of 35 patients (10%) survived to hospital discharge with a cerebral performance category (CPC) Score of 1-2; survival in the ED was 28.3%. The causes of cardiac arrests were identified in 212 cases (60.6%) and included coronary thrombosis (35%), hypoxia (22%), hypovolemia (17%), pulmonary embolism (11%), metabolic (8%), cardiac tamponade (4%), toxins (2%) and hypothermia (1%). Variables associated with survival with a favourable neurological outcome were young age, a lower Charlson Comorbidity Index, coronary thrombosis as the primary EDCA cause, and shockable presenting rhythm; however, only the latter was associated with the outcome in a multivariate age-weighted model. Conclusions : In a cohort of patients with EDCA over a period of more than a decade, the most frequent cause identified was coronary thrombosis; 10% of patients survived with a good neurological status, and the only factor associated with the best prognosis was presenting a shockable rhythm. EDCA should be considered an independent category in order to fully understand its characteristics and outcomes.

Published
2024
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27. Diagnosis and management of urinary tract infections in children aged 2 months to 3 years in the Italian emergency units: the ItaUTI study

Author

Cenzato, F, Milani, G, Amigoni, A, Sperotto, F, Bianchetti, M, Agostoni, C, Montini, G, Farello, G, Chiarelli, F, Greco, R, Di Lollo, F, Rocco Forte, F, Manieri, S, Carpino, L, Caloiero, M, Cirisano, A, Bragho, S, Della Casa, R, Nunziata, F, Pecoraro, C, Pacifico, R, Lanari, M, Ghizzi, C, Serra, L, Stella, M, Maggiore, G, Fiorini, R, Dodi, I, Morelli, A, Lughetti, L, Cella, A, Vergine, G, De Fanti, A, Dragovic, D, Santori, D, Cozzi, G, Cogo, P, Raponi, M, Lubrano, R, de Martinis, M, Gatto, A, Barbieri, M, Reale, A, Bracaglia, G, Piccotti, E, Borea, R, Gaiero, A, Martelli, L, Arrighini, A, Cianci, P, Cavalli, C, De Santis, L, Pietra, B, Biondi, A, Sala, M, Pogliani, L, Cherubini, S, Bellini, M, Bruni, P, Traina, G, Tommasi, P, Del Barba, P, Arrigoni, S, Salvini, F, Bernardo, L, Bertolozzi, G, Fasoli, S, Marseglia, G, Palumbo, E, Bosco, A, Mirri, G, Fabiani, E, Ruffini, E, Pieragostini, L, Fornaro, M, Ripanti, G, Pannoni, D, Enrico, F, Perona, A, Tappi, E, Nis Haitink, O, Rabbone, I, Capalbo, P, Urbino, A, Guala, A, Cosi, G, Barracchia, M, Martire, B, Cardinale, F, Moramarco, F, Perrone, C, Campanozzi, A, Cecinati, V, Canetto, A, Clemente, C, Cualbu, A, Narducci, F, Mula, G, Bulciolu, P, Antonucci, R, Gramaglia, G, Cavaleri, G, Salpietro, C, Corsello, G, Salvo, R, Palmeri, M, Vitale, M, Morgano, A, Falorni, S, Peroni, D, Masi, S, Bertini, A, Vaccaro, A, Vasarri, P, Reinstadler, P, Soffiati, M, Stefanelli, M, Verrotti di Pianella, A, Bertone, C, Marzini, S, Da Dalt, L, Rugolotto, S, Scozzola, F, Ecclesio Livio, L, Cinquetti, M, Silvagni, D, Bellettato, M, Cenzato F., Milani G. P., Amigoni A., Sperotto F., Bianchetti M. G., Agostoni C., Montini G., Farello G., Chiarelli F., Greco R., Di Lollo F., Rocco Forte F., Manieri S., Carpino L., Caloiero M., Cirisano A., Bragho S., Della Casa R., Nunziata F., Pecoraro C., Pacifico R., Lanari M., Ghizzi C., Serra L., Stella M., Maggiore G., Fiorini R., Dodi I., Morelli A., Lughetti L., Cella A., Vergine G., De Fanti A., Dragovic D., Santori D., Cozzi G., Cogo P., Raponi M., Lubrano R., de Martinis M., Gatto A., Barbieri M. A., Reale A., Bracaglia G., Piccotti E., Borea R., Gaiero A., Martelli L., Arrighini A., Cianci P., Cavalli C., De Santis L., Pietra B. C., Biondi A., Sala M., Pogliani L. M., Cherubini S., Bellini M., Bruni P., Traina G., Tommasi P., Del Barba P., Arrigoni S., Salvini F. M., Bernardo L., Bertolozzi G., Fasoli S., Marseglia G. L., Palumbo E., Bosco A., Mirri G., Fabiani E., Ruffini E., Pieragostini L., Fornaro M., Ripanti G., Pannoni D., Enrico F., Perona A., Tappi E., Nis Haitink O., Rabbone I., Capalbo P. T., Urbino A., Guala A., Cosi G., Barracchia M. G., Martire B., Cardinale F., Moramarco F., Perrone C., Campanozzi A., Cecinati V., Canetto A., Clemente C., Cualbu A., Narducci F., Mula G., Bulciolu P., Antonucci R., Gramaglia G., Cavaleri G., Salpietro C., Corsello G., Salvo R., Palmeri M., Vitale M. A., Morgano A., Falorni S., Peroni D., Masi S., Bertini A., Vaccaro A., Vasarri P., Reinstadler P., Soffiati M., Stefanelli M., Verrotti di Pianella A., Bertone C., Marzini S., Da Dalt L., Rugolotto S., Scozzola F., Ecclesio Livio L., Cinquetti M., Silvagni D., Bellettato M., Cenzato, F, Milani, G, Amigoni, A, Sperotto, F, Bianchetti, M, Agostoni, C, Montini, G, Farello, G, Chiarelli, F, Greco, R, Di Lollo, F, Rocco Forte, F, Manieri, S, Carpino, L, Caloiero, M, Cirisano, A, Bragho, S, Della Casa, R, Nunziata, F, Pecoraro, C, Pacifico, R, Lanari, M, Ghizzi, C, Serra, L, Stella, M, Maggiore, G, Fiorini, R, Dodi, I, Morelli, A, Lughetti, L, Cella, A, Vergine, G, De Fanti, A, Dragovic, D, Santori, D, Cozzi, G, Cogo, P, Raponi, M, Lubrano, R, de Martinis, M, Gatto, A, Barbieri, M, Reale, A, Bracaglia, G, Piccotti, E, Borea, R, Gaiero, A, Martelli, L, Arrighini, A, Cianci, P, Cavalli, C, De Santis, L, Pietra, B, Biondi, A, Sala, M, Pogliani, L, Cherubini, S, Bellini, M, Bruni, P, Traina, G, Tommasi, P, Del Barba, P, Arrigoni, S, Salvini, F, Bernardo, L, Bertolozzi, G, Fasoli, S, Marseglia, G, Palumbo, E, Bosco, A, Mirri, G, Fabiani, E, Ruffini, E, Pieragostini, L, Fornaro, M, Ripanti, G, Pannoni, D, Enrico, F, Perona, A, Tappi, E, Nis Haitink, O, Rabbone, I, Capalbo, P, Urbino, A, Guala, A, Cosi, G, Barracchia, M, Martire, B, Cardinale, F, Moramarco, F, Perrone, C, Campanozzi, A, Cecinati, V, Canetto, A, Clemente, C, Cualbu, A, Narducci, F, Mula, G, Bulciolu, P, Antonucci, R, Gramaglia, G, Cavaleri, G, Salpietro, C, Corsello, G, Salvo, R, Palmeri, M, Vitale, M, Morgano, A, Falorni, S, Peroni, D, Masi, S, Bertini, A, Vaccaro, A, Vasarri, P, Reinstadler, P, Soffiati, M, Stefanelli, M, Verrotti di Pianella, A, Bertone, C, Marzini, S, Da Dalt, L, Rugolotto, S, Scozzola, F, Ecclesio Livio, L, Cinquetti, M, Silvagni, D, Bellettato, M, Cenzato F., Milani G. P., Amigoni A., Sperotto F., Bianchetti M. G., Agostoni C., Montini G., Farello G., Chiarelli F., Greco R., Di Lollo F., Rocco Forte F., Manieri S., Carpino L., Caloiero M., Cirisano A., Bragho S., Della Casa R., Nunziata F., Pecoraro C., Pacifico R., Lanari M., Ghizzi C., Serra L., Stella M., Maggiore G., Fiorini R., Dodi I., Morelli A., Lughetti L., Cella A., Vergine G., De Fanti A., Dragovic D., Santori D., Cozzi G., Cogo P., Raponi M., Lubrano R., de Martinis M., Gatto A., Barbieri M. A., Reale A., Bracaglia G., Piccotti E., Borea R., Gaiero A., Martelli L., Arrighini A., Cianci P., Cavalli C., De Santis L., Pietra B. C., Biondi A., Sala M., Pogliani L. M., Cherubini S., Bellini M., Bruni P., Traina G., Tommasi P., Del Barba P., Arrigoni S., Salvini F. M., Bernardo L., Bertolozzi G., Fasoli S., Marseglia G. L., Palumbo E., Bosco A., Mirri G., Fabiani E., Ruffini E., Pieragostini L., Fornaro M., Ripanti G., Pannoni D., Enrico F., Perona A., Tappi E., Nis Haitink O., Rabbone I., Capalbo P. T., Urbino A., Guala A., Cosi G., Barracchia M. G., Martire B., Cardinale F., Moramarco F., Perrone C., Campanozzi A., Cecinati V., Canetto A., Clemente C., Cualbu A., Narducci F., Mula G., Bulciolu P., Antonucci R., Gramaglia G., Cavaleri G., Salpietro C., Corsello G., Salvo R., Palmeri M., Vitale M. A., Morgano A., Falorni S., Peroni D., Masi S., Bertini A., Vaccaro A., Vasarri P., Reinstadler P., Soffiati M., Stefanelli M., Verrotti di Pianella A., Bertone C., Marzini S., Da Dalt L., Rugolotto S., Scozzola F., Ecclesio Livio L., Cinquetti M., Silvagni D., and Bellettato M.

Abstract

Urinary tract infections (UTIs) are among the most frequent bacterial diseases in infants and children. Physician adherence to recommendations is notoriously often poor, but no data are available on UTIs management in the emergency setting. In this multicenter national study, we investigated the policies regarding UTIs management in children aged 2 months to 3 years in Italian emergency units. Between April and June 2021, directors of the emergency units were invited to answer an online survey on the following items: diagnostic approach to children with fever without an apparent source, therapeutic approach to UTIs, the use of kidney and urinary tract ultrasound, and the criteria for hospitalization. A total of 121 (89%) out of 139 of invited units participated in the study. Overall, units manage children with a suspected or confirmed UTI according to available recommendations for most of the items. However, in almost 80% (n = 94) of units, a sterile perineal bag is used to collect urine for culture. When urine is collected by cathether, heterogeneity exists on the threshold of bacterial load considered for UTI diagnosis. Conclusions: Available recommendations on UTIs in children are followed by Italian emergency units for most of the items. However, the methods to collect urine specimens for culture, one of the crucial steps of the diagnostic work-up, often do not align with current recommendations and CFU thresholds considered for diagnosis largely vary among centers. Efforts should be addressed to validate and implement new child and family friendly urine collection techniques.What is Known:• Several guidelines are published on the management of children with suspected or confirmed urinary tract infection.• No data are available on the management of pediatric urinary tract infections in the emergency setting.What is New:• Almost 80% of the Italian emergency units employ a sterile perineal bag to collect urine for culture.• Diagnostic

Published
2022

28. The Forward Physics Facility at the High-Luminosity LHC

Author

Feng, JL, Feng, JL, Kling, F, Reno, MH, Rojo, J, Soldin, D, Anchordoqui, LA, Boyd, J, Ismail, A, Harland-Lang, L, Kelly, KJ, Pandey, V, Trojanowski, S, Tsai, YD, Alameddine, JM, Araki, T, Ariga, A, Ariga, T, Asai, K, Bacchetta, A, Balazs, K, Barr, AJ, Battistin, M, Bian, J, Bertone, C, Bai, W, Bakhti, P, Baha Balantekin, A, Barman, B, Batell, B, Bauer, M, Bauer, B, Becker, M, Berlin, A, Bertuzzo, E, Bhattacharya, A, Bonvini, M, Boogert, ST, Boyarsky, A, Bramante, J, Brdar, V, Carmona, A, Casper, DW, Celiberto, FG, Cerutti, F, Chachamis, G, Chauhan, G, Citron, M, Copello, E, Corso, JP, Darmé, L, D'Agnolo, RT, Darvishi, N, Das, A, De Lellis, G, De Roeck, A, De Vries, J, Dembinski, HP, Demidov, S, Deniverville, P, Denton, PB, Deppisch, FF, Bhupal Dev, PS, Di Crescenzo, A, Dienes, KR, Diwan, MV, Dreiner, HK, Du, Y, Dutta, B, Duwentäster, P, Elie, L, Ellis, SAR, Enberg, R, Farzan, Y, Fieg, M, Foguel, AL, Foldenauer, P, Foroughi-Abari, S, Fortin, JF, Friedland, A, Fuchs, E, Fucilla, M, Gallmeister, K, Garcia, A, Canal, CAG, Garzelli, MV, Gauld, R, Ghosh, S, Ghoshal, A, Gibson, S, Giuli, F, Gonçalves, VP, Gorbunov, D, Goswami, S, Grau, S, Günther, JY, Guzzi, M, Haas, A, Hakulinen, T, Harris, SP, Harz, J, Feng, JL, Feng, JL, Kling, F, Reno, MH, Rojo, J, Soldin, D, Anchordoqui, LA, Boyd, J, Ismail, A, Harland-Lang, L, Kelly, KJ, Pandey, V, Trojanowski, S, Tsai, YD, Alameddine, JM, Araki, T, Ariga, A, Ariga, T, Asai, K, Bacchetta, A, Balazs, K, Barr, AJ, Battistin, M, Bian, J, Bertone, C, Bai, W, Bakhti, P, Baha Balantekin, A, Barman, B, Batell, B, Bauer, M, Bauer, B, Becker, M, Berlin, A, Bertuzzo, E, Bhattacharya, A, Bonvini, M, Boogert, ST, Boyarsky, A, Bramante, J, Brdar, V, Carmona, A, Casper, DW, Celiberto, FG, Cerutti, F, Chachamis, G, Chauhan, G, Citron, M, Copello, E, Corso, JP, Darmé, L, D'Agnolo, RT, Darvishi, N, Das, A, De Lellis, G, De Roeck, A, De Vries, J, Dembinski, HP, Demidov, S, Deniverville, P, Denton, PB, Deppisch, FF, Bhupal Dev, PS, Di Crescenzo, A, Dienes, KR, Diwan, MV, Dreiner, HK, Du, Y, Dutta, B, Duwentäster, P, Elie, L, Ellis, SAR, Enberg, R, Farzan, Y, Fieg, M, Foguel, AL, Foldenauer, P, Foroughi-Abari, S, Fortin, JF, Friedland, A, Fuchs, E, Fucilla, M, Gallmeister, K, Garcia, A, Canal, CAG, Garzelli, MV, Gauld, R, Ghosh, S, Ghoshal, A, Gibson, S, Giuli, F, Gonçalves, VP, Gorbunov, D, Goswami, S, Grau, S, Günther, JY, Guzzi, M, Haas, A, Hakulinen, T, Harris, SP, and Harz, J

Abstract

High energy collisions at the High-Luminosity Large Hadron Collider (LHC) produce a large number of particles along the beam collision axis, outside of the acceptance of existing LHC experiments. The proposed Forward Physics Facility (FPF), to be located several hundred meters from the ATLAS interaction point and shielded by concrete and rock, will host a suite of experiments to probe standard model (SM) processes and search for physics beyond the standard model (BSM). In this report, we review the status of the civil engineering plans and the experiments to explore the diverse physics signals that can be uniquely probed in the forward region. FPF experiments will be sensitive to a broad range of BSM physics through searches for new particle scattering or decay signatures and deviations from SM expectations in high statistics analyses with TeV neutrinos in this low-background environment. High statistics neutrino detection will also provide valuable data for fundamental topics in perturbative and non-perturbative QCD and in weak interactions. Experiments at the FPF will enable synergies between forward particle production at the LHC and astroparticle physics to be exploited. We report here on these physics topics, on infrastructure, detector, and simulation studies, and on future directions to realize the FPF's physics potential.

Published
2023

30. RPE65-Associated Retinopathies in the Italian Population: A Longitudinal Natural History Study

Author

Testa, F., Murro, V., Signorini, S., Colombo, L., Iarossi, G., Parmeggiani, F., Falsini, Benedetto, Salvetti, A. P., Brunetti-Pierri, R., Aprile, G., Bertone, C., Suppiej, A., Romano, Federica, Karali, M., Donati, S., Melillo, P., Sodi, A., Quaranta, L., Rossetti, Lodovico, Buzzonetti, Luca, Chizzolini, M., Rizzo, Stanislao, Staurenghi, G., Banfi, S., Azzolini, Chiara, Simonelli, F., Falsini B. (ORCID:0000-0002-3569-4968), Romano F., Rossetti L., Buzzonetti L. (ORCID:0000-0002-3200-3260), Rizzo S. (ORCID:0000-0001-6302-063X), Azzolini C. (ORCID:0000-0001-7270-577X), Testa, F., Murro, V., Signorini, S., Colombo, L., Iarossi, G., Parmeggiani, F., Falsini, Benedetto, Salvetti, A. P., Brunetti-Pierri, R., Aprile, G., Bertone, C., Suppiej, A., Romano, Federica, Karali, M., Donati, S., Melillo, P., Sodi, A., Quaranta, L., Rossetti, Lodovico, Buzzonetti, Luca, Chizzolini, M., Rizzo, Stanislao, Staurenghi, G., Banfi, S., Azzolini, Chiara, Simonelli, F., Falsini B. (ORCID:0000-0002-3569-4968), Romano F., Rossetti L., Buzzonetti L. (ORCID:0000-0002-3200-3260), Rizzo S. (ORCID:0000-0001-6302-063X), and Azzolini C. (ORCID:0000-0001-7270-577X)

Abstract

PURPOSE. To investigate the course of inherited retinal degenerations (IRD) due to mutations in the RPE65 gene. METHODS. This longitudinal multicentric retrospective chart-review study was designed to collect best corrected visual acuity (BCVA), Goldman visual field, optical coherence tomography (OCT), and electroretinography (ERG) measurements. The data, including imaging, were collected using an electronic clinical research form and were reviewed at a single center to improve consistency. RESULTS. From an overall cohort of 60 Italian patients with RPE65-associated IRD, 43 patients (mean age, 27.8 ± 19.7 years) were included and showed a mean BCVA of 2.0 ± 1.0 logMAR. Time-to-event analysis revealed a median age of 33.8 years and 41.4 years to reach low vision and blindness based on BCVA, respectively. ERG (available for 34 patients) showed undetectable responses in most patients (26; 76.5%). OCT (available for 31 patients) revealed epiretinal membranes in five patients (16.1%). Central foveal thickness significantly decreased with age at a mean annual rate of −0.6%/y (P = 0.044). We identified 43 different variants in the RPE65 gene in the entire cohort. Nine variants were novel. Finally, to assess genotype-phenotype correlations, patients were stratified according to the number of RPE65 loss-of-function (LoF) alleles. Patients without LoF variants showed significantly (P < 0.05) better BCVA compared to patients with one or two LoF alleles. CONCLUSIONS. We described the natural course of RPE65-associated IRD in an Italian cohort showing for the first time a specific genotype-phenotype association. Our findings can contribute to a better management of RPE65-associated IRD patients.

Published
2022

31. Visual Function and Neuropsychological Profiling of Idiopathic Infantile Nystagmus.

Author

Morelli F, Catalano G, Scognamillo I, Balzarotti N, Luparia A, Olivier L, Bertone C, Gori M, and Signorini S

Abstract

Though considered a benign condition, idiopathic infantile nystagmus (IIN) may be associated with decreased visual acuity and oculo-motor abnormalities, resulting in developmental delays and poor academic performance. Nevertheless, the specific visual function profile of IIN and its possible impact on neuropsychological development have been poorly investigated. To fill this gap, we retrospectively collected the clinical data of 60 children presenting with IIN over a 10-year period (43 male; mean age of 7 years, range of 2 months-17 years, 9 months). The majority of the subjects in our cohort presented with reduced visual acuity for far distances and normal visual acuity for near distances, associated with oculo-motor abnormalities. The overall scores of cognitive and visual-cognitive tests were in the normal range, but revealed peculiar cognitive and visual-cognitive profiles, defined by specific frailties in processing speed and visual-motor integration. The same neuropsychological profiles characterize many neurodevelopmental disorders and may express a transnosographic vulnerability of the dorsal stream. As the first study to explore the neuropsychologic competencies in children with IIN, our study unveils the presence of subclinical frailties that need to be addressed to sustain academic and social inclusion.

Published
2023
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35. Technical infrastructure

Author

Tavian, L., Battistin, M., Bertolasi, S., Bertone, C., Di Girolamo, B., Dos Santos, N., Foraz, K., Hakulinen, T., Mattelaer, P., Muffat, P., and Pepinster, P.

Abstract

The HL-LHC technical infrastructure includes the civil engineering, the electrical distribution, the cooling & ventilation, the access & alarm system, the technical monitoring, the transport, the logistics, the storage, and the operational safety., CERN Yellow Reports: Monographs, Vol. 10 (2020): High-Luminosity Large Hadron Collider (HL-LHC): Technical design report

Published
2020
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36. Chapter 17: Technical infrastructure

Author

Tavian, L, Battistin, M, Bertolasi, S, Bertone, C, Di Girolamo, B, Dos Santos, N, Foraz, K, Hakulinen, T, Mattelaer, P, Muffat, P, and Pepinster, P

Subjects
Accelerators and Storage Rings
Abstract

The HL-LHC technical infrastructure includes the civil engineering, the electrical distribution, the cooling & ventilation, the access & alarm system, the technical monitoring, the transport, the logistics, the storage, and the operational safety.

Published
2020

38. High-Luminosity Large Hadron Collider (HL-LHC): Technical design report

Author

Aberle, O., Béjar Alonso, I, Brüning, O, Fessia, P, Rossi, L, Tavian, L, Zerlauth, M, Adorisio, C., Adraktas, A., Ady, M., Albertone, J., Alberty, L., Alcaide Leon, M., Alekou, A., Alesini, D., Ferreira, B. Almeida, Lopez, P. Alvarez, Ambrosio, G., Andreu Munoz, P., Anerella, M., Angal-Kalinin, D., Antoniou, F., Apollinari, G., Apollonio, A., Appleby, R., Arduini, G., Alonso, B. Arias, Artoos, K., Atieh, S., Auchmann, B., Badin, V., Baer, T., Baffari, D., Baglin, V., Bajko, M., Ball, A., Ballarino, A., Bally, S., Bampton, T., Banfi, D., Barlow, R., Barnes, M., Barranco, J., Barthelemy, L., Bartmann, W., Bartosik, H., Barzi, E., Battistin, M., Baudrenghien, P., Alonso, I. Bejar, Belomestnykh, S., Benoit, A., Ben-Zvi, I., Bertarelli, A., Bertolasi, S., Bertone, C., Bertran, B., Bestmann, P., Biancacci, N., Bignami, A., Bliss, N., Boccard, C., Body, Y., Borburgh, J., Bordini, B., Borralho, F., Bossert, R., Bottura, L., Boucherie, A., Bozzi, R., Bracco, C., Bravin, E., Bregliozzi, G., Brett, D., Broche, A., Brodzinski, K., Broggi, F., Bruce, R., Brugger, M., Brüning, O., Buffat, X., Burkhardt, H., Burnet, J., Burov, A., Burt, G., Cabezas, R., Cai, Y., Calaga, R., Calatroni, S., Capatina, O., Capelli, T., Cardon, P., Carlier, E., Carra, F., Carvalho, A., Carver, L.R., Caspers, F., Cattenoz, G., Cerutti, F., Chancé, A., Rodrigues, M. Chastre, Chemli, S., Cheng, D., Chiggiato, P., Chlachidze, G., Claudet, S., Coello De Portugal, JM., Collazos, C., Corso, J., Costa Machado, S., Costa Pinto, P., Coulinge, E., Crouch, M., Cruikshank, P., Cruz Alaniz, E., Czech, M., Dahlerup-Petersen, K., Dalena, B., Daniluk, G., Danzeca, S., Day, H., De Carvalho Saraiva, J., De Luca, D., De Maria, R., De Rijk, G., De Silva, S., Dehning, B., Delayen, J., Deliege, Q., Delille, B., Delsaux, F., Denz, R., Devred, A., Dexter, A., Di Girolamo, B., Dietderich, D., Dilly, J.W., Doherty, A., Dos Santos, N., Drago, A., D.Drskovic, Ramos, D. Duarte, Ducimetière, L., Efthymiopoulos, I., Einsweiler, K., Esposito, L., Esteban Muller, J., Evrard, S., Fabbricatore, P., Farinon, S., Fartoukh, S., Faus-Golfe, A., Favre, G., Felice, H., Feral, B., Ferlin, G., Ferracin, P., Ferrari, A., Ferreira, L., Fessia, P., Ficcadenti, L., Fiotakis, S., Fiscarelli, L., Fitterer, M., Fleiter, J., Foffano, G., Fol, E., Folch, R., Foraz, K., Foussat, A., Frankl, M., Frasciello, O., Fraser, M., Menendez, P. Freijedo, Fuchs, J-F., Furuseth, S., Gaddi, A., Gallilee, M., Gallo, A., Alia, R. Garcia, Gavela, H. Garcia, Matos, J. Garcia, Garcia Morales, H., Valdivieso, A. Garcia-Tabares, Garino, C., Garion, C., Gascon, J., Gasnier, Ch., Gentini, L., Gentsos, C., Ghosh, A., Giacomel, L., Hernandez, K. Gibran, Gibson, S., Ginburg, C., Giordano, F., Giovannozzi, M., Goddard, B., Gomes, P., Gonzalez De La Aleja Cabana, M., Goudket, P., Gousiou, E., Gradassi, P., Costa, A. Granadeiro, Grand-Clément, L., Grillot, S., Guillaume, JC., Guinchard, M., Hagen, P., Hakulinen, T., Hall, B., Hansen, J., Heredia Garcia, N., Herr, W., Herty, A., Hill, C., Hofer, M., Höfle, W., Holzer, B., Hopkins, S., Hrivnak, J., Iadarola, G., Infantino, A., Bermudez, S. Izquierdo, Jakobsen, S., Jebramcik, M.A., Jenninger, B., Jensen, E., Jones, M., Jones, R., Jones, T., Jowett, J., Juchno, M., Julie, C., Junginger, T., Kain, V., Kaltchev, D., Karastathis, N., Kardasopoulos, P., Karppinen, M., Keintzel, J., Kersevan, R., Killing, F., Kirby, G., Korostelev, M., Kos, N., Kostoglou, S., Kozsar, I., Krasnov, A., Krave, S., Krzempek, L., Kuder, N., Kurtulus, A., Kwee-Hinzmann, R., Lackner, F., Lamont, M., Lamure, A.L., m, L. Lari, Lazzaroni, M., Le Garrec, M., Lechner, A., Lefevre, T., Leuxe, R., Li, K., Li, Z., Lindner, R., Lindstrom, B., Lingwood, C., Löffler, C., Lopez, C., Lopez-Hernandez, LA., Losito, R., Maciariello, F., Macintosh, P., Maclean, E.H., Macpherson, A., Maesen, P., Magnier, C., Durand, H. Mainaud, Malina, L., Manfredi, M., Marcellini, F., Marchevsky, M., Maridor, S., Marinaro, G., Marinov, K., Markiewicz, T., Marsili, A., Martinez Urioz, P., Martino, M., Masi, A., Mastoridis, T., Mattelaer, P., May, A., Mazet, J., Mcilwraith, S., McIntosh, E., Medina Medrano, L., Mejica Rodriguez, A., Mendes, M., Menendez, P., Mensi, M., Mereghetti, A., Mergelkuhl, D., Mertens, T., Mether, L., Métral, E., Migliorati, M., Milanese, A., Minginette, P., Missiaen, D., Mitsuhashi, T., Modena, M., Mokhov, N., Molson, J., Monneret, E., Montesinos, E., Moron-Ballester, R., Morrone, M., Mostacci, A., Mounet, N., Moyret, P., Muffat, P., Muratori, B., Muttoni, Y., Nakamoto, T., Navarro-Tapia, M., Neupert, H., Nevay, L., Nicol, T., Nilsson, E., Ninin, P., Nobrega, A., Noels, C., Nolan, E., Nosochkov, Y., Nuiry, FX., Oberli, L., Ogitsu, T., Ohmi, K., Olave R., Oliveira, J., Orlandi, Ph., Ortega, P., Osborne, J., Otto, T., Palumbo, L., Papadopoulou, S., Papaphilippou, Y., Paraschou, K., Parente, C., Paret, S., Park, H., Parma, V., Pasquino, Ch., Patapenka, A., Patnaik, L., Pattalwar, S., Payet, J., Pechaud, G., Pellegrini, D., Pepinster, P., Perez, J., Espinos, J. Perez, Marcone, A. Perillo, Perin, A., Perini, P., Persson, T.H.B., Peterson, T., Pieloni, T., Pigny, G., Pinheiro de Sousa, J.P., Pirotte, O., Plassard, F., Pojer, M., Pontercorvo, L., Poyet, A., Prelipcean, D., Prin, H., Principe, R., Pugnat, T., Qiang, J., Quaranta, E., Rafique, H., Rakhno, I., Duarte, D. Ramos, Ratti, A., Ravaioli, E., Raymond, M., Redaelli, S., Renaglia, T., Ricci, D., Riddone, G., Rifflet, J., Rigutto, E., Rijoff, T., Rinaldesi, R., Riu Martinez, O., Rivkin, L., Rodriguez Mateos, F., Roesler, S., Romera Ramirez, I., Rossi, A., Rossi, L., Rude, V., Rumolo, G., Rutkovksi, J., Sabate Gilarte, M., Sabbi, G., Sahner, T., Salemme, R., Salvant, B., Galan, F. Sanchez, Santamaria Garcia, A., Santillana, I., Santini, C., Santos, O., Diaz, P. 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Vittal, Vlachoudis, V., Volpini, G., Wagner, U., Wanderer, P., Wang, M., Wang, X., Wanzenberg, R., Wegscheider, A., Weisz, S., Welsch, C., Wendt, M., Wenninger, J., Weterings, W., White, S., Widuch, K., Will, A., Willering, G., Wollmann, D., Wolski, A., Wozniak, J., Wu, Q., Xiao, B., Xiao, L., Xu, Q., Yakovlev, Y., Yammine, S., Yang, Y., Yu, M., Zacharov, I., Zagorodnova, O., Zannini, C., Zanoni, C., Zerlauth, M., Zimmermann, F., Zlobin, A., Zobov, M., and Zurbano Fernandez, I.

Subjects
Accelerators and Storage Rings
Abstract

The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up anew energy frontier for exploration in 2010, it has gathered a global user community of about 9000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its instantaneous luminosity (rate of collisions) by a factor of five beyond the original design valueand the integrated luminosity (totalnumber of collisions) by a factor ten. The LHC is already a highly complexand exquisitely optimised machine so this upgrade must be carefully conceived and will require new infrastructures(underground and on surface)and over a decade to implement. The new configuration, known as High Luminosity LHC (HL-LHC), relies on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11–12Tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 100 metre-long high-power superconducting links with negligible energy dissipation, all of which required several years of dedicated R&D; effort on a global international level. The present document describes the technologies and components that will be used to realise the projectand is intended to serve as the basis for the detailed engineering design of the HL-LHC.

Published
2020

40. Acute coronary syndrome after initiation of amoxicillin/clavulanate.

Author

Giamello JD, Bertone C, Sobrero G, Barutta L, Paglietta G, Losardo L, and Lauria G

Subjects
Male, Humans, Middle Aged, Amoxicillin-Potassium Clavulanate Combination adverse effects, Coronary Angiography, Electrocardiography, Emergency Service, Hospital, Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome diagnostic imaging
Abstract

We report the case of a 54 year old man referred to the Emergency Department for rapid onset of an itchy rash and oppressive epigastric pain after assumption of amoxicillin/clavulanate. Electrocardiogram aand laboratory findings were consistent with acute coronaty syndrome. After coronary angiography, diagnosis of type II Kounis syndrome was made.

Published
2023
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46. The role of hypochlorous acid in the management of eye infections: a case series.

Author

Bertone C, Mollicone A, Russo S, Sasso P, Fasciani R, Riccardi C, and Lizzano M

Abstract

Experiences from clinical practice suggest that hypochlorous acid (HOCl) used as adjuvant treatment can shorten the time to clinical resolution of blepharitis, particularly in relation to the ophthalmic complications that often occur with a blepharitis diagnosis. In addition, in clinical practice, HOCl adjuvant treatment also resulted in a viable option for the management of ophthalmic disorders other than blepharitis. This case series presents and discusses real-life experiences with using an HOCl ophthalmic spray to manage eye infections, further characterizing the use of HOCl for ophthalmic applications., Competing Interests: Disclosure and potential conflicts of interest: None of the authors declared conflict of interests. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2022/05/dic.2022-3-10-COI.pdf, (Copyright © 2022 Bertone C, Mollicone A, Russo S, Sasso P, Fasciani R, Riccardi C, Lizzano M, the ALI working group.)

Published
2022
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47. Optical coherence tomography angiography in healthy children: A comparison of macular structure.

Author

Plaitano C, Periti F, Guagliano R, Bertone C, Barillà D, Arpa C, Tinelli C, Gallo FG, Bianchi A, and Magli A

Subjects
Birth Weight, Child, Fluorescein Angiography methods, Fovea Centralis blood supply, Humans, Retinal Vessels diagnostic imaging, Retrospective Studies, Refractive Errors, Tomography, Optical Coherence methods
Abstract

Purpose: The purpose of the present study was to investigate the perfusion density (PD) of macular superficial (SCP) and deep capillary plexus (DCP), the size of foveal avascular zone (FAZ) and central macular thickness (CMT) in healthy children using optical coherence tomography angiography (OCT-A)., Patients and Methods: About 206 eyes of 111 children were analyzed. The correlation of gestational age (GA), birth weight (BW), age, sex, refractive errors, and visual acuity (VA) with OCT-A parameters were investigated., Results: The mean PD of the fovea and the mean FAZ area of SCP were 17.1% (DS: 4.26) and 234.47 (DS: 106.39) µm 2 . The mean PD of the fovea and the mean FAZ area of DCP were 13.5% (DS: 5.23) and 298.32 (DS: 112.37) µm 2 . Superficial and deep FAZ areas were not correlated with sex, age, BW, refractive errors, or VA. FAZ area of SCP was correlated with foveal PD ( r  = -0.76) and with CMT ( r  = -0.68). FAZ area of DCP was correlated with foveal's PD ( r  = -0.61). There was no correlation between CMT and refractive errors., Conclusion: OCT-A may provide a non-invasive and reliable approach to evaluate macular perfusion in children. As the FAZ area, PD, and CMT change during the growth period, we performed established a reference range for different ages.

Published
2022
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48. Evaluation of macular and optic nerve head parameters in amblyopic eyes: An optical coherence tomography study.

Author

Guagliano R, Barillà D, Bertone C, Montescani S, Verticchio Vercellin AC, Arpa C, Tinelli C, De Angelis G, and Quaranta L

Subjects
Child, Humans, Retinal Ganglion Cells, Tomography, Optical Coherence methods, Visual Acuity, Amblyopia, Optic Disk
Abstract

Purpose: To evaluate morphological differences in retinal nerve fibers layers (RNFL), optic nerve head (ONH), ganglion cell complex (GCC), and macular thickness between amblyopic and normal eyes from spectral domain optical coherence tomography (SD-OCT)., Methods: Of 234 eyes of 117 children, four groups emerged: group A (162 eyes of 81 non-amblyopic subjects); group B (32 fellow eyes of 32 subjects with monolateral amblyopia); group C (32 amblyopic eyes of 32 subjects affected by monolateral amblyopia); group D (8 amblyopic eyes of 4 subjects with bilateral amblyopia). Patients underwent SD-OCT for ONH parameters, RNFL, GCC and macular thickness, retina map, and ONH scan quality index (SQI). Two-sided p values <0.05 were taken as statistically significant. (Analysis: STATA v.13)., Results: Parameters with a significant difference between groups ( p  < 0.005) with their Standard Deviation (SD) are presented: rim area, 2.08 (0.49) mm 2 in group A and 1.76 (0.68) mm 2 in group C; disk area, 2.43 (0.45) mm 2 in group A and 2.02 (0.71) mm 2 in group C; central macular thickness, 250.99 (19.74) µm in group A and 267.16 (23.52) µm in group C; nerve fiber ONH SQI, 62.82 (13.15) in group A, 51.26 (15.55) in group C, 48.29 (14.37) in group D; retina map SQI, 63.34 (10.34) in group A and 57.34 (9.84) in group C. For other parameters no significant difference was observed ( p  > 0.005)., Conclusions: Amblyopia may influence optic nerve morphology, central macular thickness, and OCT scan quality. RNFL and GCC are not affected by monolateral amblyopia.

Published
2022
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49. Visual Evoked Potentials in Joubert Syndrome: A Suggested Useful Method for Evaluating Future Approaches Targeted to Improve Visual Pathways' Function.

Author

Ruberto G, Parisi V, Bertone C, Signorini S, Antonini M, Valente EM, Manzoni F, Serpieri V, Fausto R, and Quaranta L

Subjects
Adolescent, Cerebellum abnormalities, Child, Child, Preschool, Electroretinography, Evoked Potentials, Visual, Humans, Prospective Studies, Retina abnormalities, Visual Pathways, Abnormalities, Multiple, Eye Abnormalities diagnosis, Kidney Diseases, Cystic diagnosis
Abstract

Introduction: Joubert syndrome (JS) is a recessive disorder characterized by a congenital malformation of the mid-hindbrain and a large spectrum of clinical features including optic nerve morphologic abnormalities. The function of the visual pathways, including the optic nerve, can be objectively evaluated by visual evoked potential (VEP) recordings. Our work aims to employ VEP to evaluate the neural conduction along the visual pathways in JS patients with or without optic nerve morphologic abnormalities (ONMA)., Methods: In this observational and prospective study, 18 children with genetic diagnosis of JS (mean age 8.78 ± 5.87 years) and 17 healthy age-similar control subjects (control group, 9.05 ± 6.02 years) were enrolled. Based on presence/absence of ONMA at fundus examination, JS patients were divided into two groups: the JS-A group (eight patients with ONMA) and JS-N group (ten patients without ONMA). Following the ISCEV standards, pattern VEPs were recorded in patients and controls in response to 60' and 15' checks to obtain a prevalent activation of large or small axons, respectively., Results: Compared to controls, both the JS-A and JS-N groups showed significant abnormalities in 60' and 15' VEP implicit time and amplitude. Only in the JS-N group were values of 15' VEP implicit significantly correlated with the corresponding values of visual acuity., Conclusions: Our results suggest that a visual pathways dysfunction (of both large and small axons) detectable by VEP may occur in JS patients regardless of the presence of ONMA. Since clinical trials are envisaged in the near future to address JS-related ocular problems, our results might provide information about the potential usefulness of VEP recordings to assess the efficacy of treatments targeted to improve the visual pathways' function.

Published
2021
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