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The Cd40l(-/-) mouse is a well-established model of X-linked hyper-immunoglobulin M (IgM) syndrome, an immunodeficiency disorder of human beings characterized by the lack of expression of the CD40 ligand (CD40L) on activated T-cells, predisposing to infections with opportunistic pathogens like Pneumocystis jirovecii. The aim of our study was to describe the pulmonary lesions in Cd40l(-/-) mice experimentally infected with Pneumocystis murina, in comparison with naturally infected severe combined immunodeficient (SCID) mice. Formalin-fixed paraffin-embedded lungs from 26 Cd40l(-/-), 11 SCID, and 5 uninfected Cd40l(-/-) mice were examined by histology and immunohistochemistry for the presence of the pathogen and for leukocyte populations (CD3, CD4, CD45R/B220, CD8a, Iba-1, Ly-6G, CD206, MHC II, and NKp46/NCR1). Infection was confirmed by immunohistochemistry in 18/26 (69%) Cd40l(-/-) mice and in 11/11 (100%) SCID mice. Fourteen out of 26 (54%) Cd40l(-/-) mice had interstitial pneumonia. Twenty-three out of 26 (88%) Cd40l(-/-) mice had peribronchiolar/perivascular lymphoplasmacytic infiltrates, rich in B-cells and Mott cells. Acidophilic macrophage pneumonia was additionally found in 20/26 (77%) Cd40l(-/-) mice. Only 4/11 (36%) SCID mice had interstitial pneumonia, but no peribronchiolar/perivascular infiltrates or acidophilic macrophage pneumonia were observed in this strain. This study represents the first description of pulmonary histopathological lesions in Cd40l(-/-) mice infected with P. murina. We speculate that the singular characteristics of the inflammatory infiltrates observed in Cd40l(-/-) mice could be explained by the specific immune phenotype of the model.

Gastrointestinal graft-versus-host disease (GvHD) is a major cause of mortality and morbidity following allogeneic bone marrow transplantation (allo-BMT). Chemerin is a chemotactic protein that recruits leukocytes to inflamed tissues by interacting with ChemR23/CMKLR1, a chemotactic receptor expressed by leukocytes, including macrophages. During acute GvHD, chemerin plasma levels were strongly increased in allo-BM-transplanted mice. The role of the chemerin/CMKLR1 axis in GvHD was investigated using Cmklr1-KO mice. WT mice transplanted with an allogeneic graft from Cmklr1-KO donors (t-KO) had worse survival and more severe GvHD. Histological analysis demonstrated that the gastrointestinal tract was the organ mostly affected by GvHD in t-KO mice. The severe colitis of t-KO mice was characterized by massive neutrophil infiltration and tissue damage associated with bacterial translocation and exacerbated inflammation. Similarly, Cmklr1- KO recipient mice showed increased intestinal pathology in both allogeneic transplant and dextran sulfate sodium-induced colitis. Notably, the adoptive transfer of WT monocytes into t-KO mice mitigated GvHD manifestations by decreasing gut inflammation and T cell activation. In patients, higher chemerin serum levels were predictive of GvHD development. Overall, these results suggest that CMKLR1/chemerin may be a protective pathway for the control of intestinal inflammation and tissue damage in GvHD.

The engine size of modern passenger transport aircraft is principally determined by take-off conditions, since initial acceleration requires maximum engine power. An elec¬tromagnetic launch (EML) system could provide some or all of the energy required at takeoff so that the aircraft engine power requirement and fuel consumption may be significantly reduced. So far, EML for aircraft has been adopted only for military applications to replace steam catapults on the deck of aircraft carriers. This paper will describe the potential application of EML to propel civil aircraft on the runways of modern air¬ports. A comparison of synchronous and asynchronous electrical motor systems designed to launch an A320-200 sized aircraft is presented. The paper also describes a solution of the transient heat transfer problem applied to the conductive components of EML systems.

Electromagnetic launch systems have been proposed for military applications to accelerate jet planes on aircraft carriers. This paper proposes the implementation of similar technology to aid civil aircraft take-off, which can provide significant economic, environmental and technical benefits. Assisted launch has the potential of reducing on ground noise and emissions near airports and improving overall aircraft efficiency through reducing engine thrust requirements. This paper presents a take-off performance analysis for an Airbus A320-200 taking off with and without the assistance of the electromagnetic catapult. Assisted take-off allows for a significant reduction in take-off field length, giving more capacity with existing airport footprints and reducing the necessary footprint of new airports, which will both reduce costs and increase the number of suitable sites. The electromagnetic catapult may allow the installation of smaller engines with lower rated thrust. The consequent fuel consumption and operational cost reduction is estimated. The potential of reducing the aircraft operational costs and the runway length required make electromagnetic launch system an attractive solution to the air traffic growth in busy airports.

The engine size of modern passenger transport aircraft is principally determined by take-off conditions, since initial acceleration requires maximum engine power. An Electromagnetic Launch (EML) system could provide some or all of the energy required at the launch stage so that the aircraft engine power requirement and fuel consumption may be significantly reduced. So far, EML for aircraft has been adopted only for military applications to replace steam catapults on the deck of aircraft carriers. This paper will describe the application of EML to propel civil aircraft on the runways of modern airports. A comparison of synchronous and asynchronous electrical motor systems designed to launch an A320-200 will be presented. The paper will present the solution of the transient heat transfer problem of EML systems and the respective design limitations of a civil aircraft launcher under rated current density. The experimental setup that will serve for future validation is introduced.

This paper considers the feasibility of different superconducting technologies for electromagnetic launch (EML) to assist civil aircraft take-off. EML has the potential of reducing the required runway length by increasing aircraft acceleration. Expensive airport extensions to face constant air traffic growth could be avoided by allowing large aircraft to operate from short runways at small airports. The new system positively affects total aircraft noise and exhaust emissions near airports and improves overall aircraft efficiency through reducing engine design constraints. Superconducting Linear Synchronous Motors (SCLSMs) can be exploited to deliver the required take-off thrust with electromagnetic performance that cannot be easily achieved by conventional electrical machines. The sizing procedure of a SCLSM able to launch A320 in weight is presented. Electromagnetic and thermal aspects of the machine are taken into account including the modelling of ac losses in superconductors and thermal insulation. The metallic high temperature superconductor (HTS) magnesium diboride (MgB2) is used and operated at 20 K, the boiling temperature of liquid hydrogen. With modern manufacturing technology, multifilament MgB2 wires appear to be the most cost-effective solution for this application. Finally the impact of the cryocooler efficiency on the machine performance is evaluated.

This paper considers the feasibility of different technologies for an electromagnetic launcher to assist civil aircraft take-off. This method is investigated to reduce the power required from the engines during initial acceleration. Assisted launch has the potential of reducing the required runway length, reducing noise near airports and improving overall aircraft efficiency through reducing engine thrust requirements. The research compares two possible linear motor topologies which may be efficaciously used for this application. The comparison is made on results from both analytical and finite element analysis (FEA).

The engine size of modern passenger transport aircraft is principally determined by take-off conditions, since initial acceleration requires maximum engine power. An Electromagnetic Launch (EML) system could provide some or all of the energy required at the launch stage so that the aircraft engine power requirement and fuel consumption may be significantly reduced. So far, EML for aircraft has been adopted only for military applications to replace steam catapults on the deck of aircraft carriers. This paper will describe the application of EML to propel civil aircraft on the runways of modern airports. A comparison of synchronous and asynchronous electrical motor systems designed to launch an A320-200 will be presented. The paper will present the solution of the transient heat transfer problem of EML systems and the respective design limitations of a civil aircraft launcher under rated current density. The experimental setup that will serve for future validation is introduced.

Electromagnetic launch systems have been proposed for military applications to accelerate jet planes on aircraft carriers. This paper proposes the implementation of similar technology to aid civil aircraft take-off, which can provide significant economic, environmental and technical benefits. Assisted launch has the potential of reducing on ground noise and emissions near airports and improving overall aircraft efficiency through reducing engine thrust requirements. This paper presents a take-off performance analysis for an Airbus A320-200 taking off with and without the assistance of the electromagnetic catapult. Assisted take-off allows for a significant reduction in take-off field length, giving more capacity with existing airport footprints and reducing the necessary footprint of new airports, which will both reduce costs and increase the number of suitable sites. The electromagnetic catapult may allow the installation of smaller engines with lower rated thrust. The consequent fuel consumption and operational cost reduction is estimated. The potential of reducing the aircraft operational costs and the runway length required make electromagnetic launch system an attractive solution to the air traffic growth in busy airports.

This paper compares three possible linear motor topologies for an electromagnetic launch system to assist civil aircraft take-off. Assisted launch of civil aircraft has the potential of reducing the required runway length, reducing noise and emissions near airports and improving overall aircraft efficiency through reducing engine thrust requirements. A comparison is made of practical designs of a linear induction motor, a linear permanent magnet synchronous motor and a superconducting linear synchronous motor to propel the A320-200 aircraft. The machine design requirements are established considering aerodynamic and engine performance and allow the aircraft to safely complete the take-off procedure. Analytical design of conventional synchronous and asynchronous linear motor will be compared with finite element analysis. A superconducting synchronous motor design is also considered, accounting for full system losses including the cryocooler power requirement and the mechanical & design constraints necessary for the cooler and the superconducting coils

Electromagnetic launch systems have been proposed for military applications to accelerate jet planes on aircraft carriers. This paper proposes the implementation of similar technology to aid civil aircraft take-off, which can provide significant economic, environmental and technical benefits. Assisted launch has the potential of reducing on ground noise and emissions near airports and improving overall aircraft efficiency through reducing engine thrust requirements. This paper presents a take-off performance analysis for an Airbus A320-200 taking off with and without the assistance of the electromagnetic catapult. Assisted take-off allows for a significant reduction in take-off field length, giving more capacity with existing airport footprints and reducing the necessary footprint of new airports, which will both reduce costs and increase the number of suitable sites. The electromagnetic catapult may allow the installation of smaller engines with lower rated thrust. The consequent fuel consumption and operational cost reduction is estimated. The potential of reducing the aircraft operational costs and the runway length required make electromagnetic launch system an attractive solution to the air traffic growth in busy airports.

The engine size of modern passenger transport aircraft is principally determined by take-off conditions, since initial acceleration requires maximum engine power. An Electromagnetic Launch (EML) system could provide some or all of the energy required at the launch stage so that the aircraft engine power requirement and fuel consumption may be significantly reduced. So far, EML for aircraft has been adopted only for military applications to replace steam catapults on the deck of aircraft carriers. This paper will describe the application of EML to propel civil aircraft on the runways of modern airports. A comparison of synchronous and asynchronous electrical motor systems designed to launch an A320-200 will be presented. The paper will present the solution of the transient heat transfer problem of EML systems and the respective design limitations of a civil aircraft launcher under rated current density. The experimental setup that will serve for future validation is introduced.

This paper compares three possible linear motor topologies for an electromagnetic launch system to assist civil aircraft take-off. Assisted launch of civil aircraft has the potential of reducing the required runway length, reducing noise and emissions near airports and improving overall aircraft efficiency through reducing engine thrust requirements. A comparison is made of practical designs of a linear induction motor, a linear permanent magnet synchronous motor and a superconducting linear synchronous motor to propel the A320-200 aircraft. The machine design requirements are established considering aerodynamic and engine performance and allow the aircraft to safely complete the take-off procedure. Analytical design of conventional synchronous and asynchronous linear motor will be compared with finite element analysis. A superconducting synchronous motor design is also considered, accounting for full system losses including the cryocooler power requirement and the mechanical & design constraints necessary for the cooler and the superconducting coils

Electromagnetic launch systems have been proposed for military applications to accelerate jet planes on aircraft carriers. This paper proposes the implementation of similar technology to aid civil aircraft take-off, which can provide significant economic, environmental and technical benefits. Assisted launch has the potential of reducing on ground noise and emissions near airports and improving overall aircraft efficiency through reducing engine thrust requirements. This paper presents a take-off performance analysis for an Airbus A320-200 taking off with and without the assistance of the electromagnetic catapult. Assisted take-off allows for a significant reduction in take-off field length, giving more capacity with existing airport footprints and reducing the necessary footprint of new airports, which will both reduce costs and increase the number of suitable sites. The electromagnetic catapult may allow the installation of smaller engines with lower rated thrust. The consequent fuel consumption and operational cost reduction is estimated. The potential of reducing the aircraft operational costs and the runway length required make electromagnetic launch system an attractive solution to the air traffic growth in busy airports.

The engine size of modern passenger transport aircraft is principally determined by take-off conditions, since initial acceleration requires maximum engine power. An Electromagnetic Launch (EML) system could provide some or all of the energy required at the launch stage so that the aircraft engine power requirement and fuel consumption may be significantly reduced. So far, EML for aircraft has been adopted only for military applications to replace steam catapults on the deck of aircraft carriers. This paper will describe the application of EML to propel civil aircraft on the runways of modern airports. A comparison of synchronous and asynchronous electrical motor systems designed to launch an A320-200 will be presented. The paper will present the solution of the transient heat transfer problem of EML systems and the respective design limitations of a civil aircraft launcher under rated current density. The experimental setup that will serve for future validation is introduced.

This paper compares three possible linear motor topologies for an electromagnetic launch system to assist civil aircraft take-off. Assisted launch of civil aircraft has the potential of reducing the required runway length, reducing noise and emissions near airports and improving overall aircraft efficiency through reducing engine thrust requirements. A comparison is made of practical designs of a linear induction motor, a linear permanent magnet synchronous motor and a superconducting linear synchronous motor to propel the A320-200 aircraft. The machine design requirements are established considering aerodynamic and engine performance and allow the aircraft to safely complete the take-off procedure. Analytical design of conventional synchronous and asynchronous linear motor will be compared with finite element analysis. A superconducting synchronous motor design is also considered, accounting for full system losses including the cryocooler power requirement and the mechanical & design constraints necessary for the cooler and the superconducting coils

The engine size of modern aircraft is principally determined by take-off conditions, since initial acceleration requires the maximum engine power. An Electromagnetic Launch (EML) system could provide some or all of the energy required during the take-off phase of the flight so that the engine power requirement and fuel use could be significantly reduced. EML also has the potential of reducing the required runway length by increasing aircraft acceleration. Expensive airport extensions to face constant air traffic growth might then be avoided by allowing large aircraft to operate from short runways at small airports. The proposed system has positive impacts on total aircraft noise and exhaust emissions near airports and improves overall aircraft efficiency through reducing engine design constraints. So far, EML for aircraft has been adopted only for military applications to replace steam catapults on the deck of aircraft carriers. This thesis considers the feasibility of different technologies for EML systems to assist civil aircraft takeoff. The research develops, models, designs and compares three possible linear motor topologies which may be used to propel an A320-200 sized aircraft up to the take-off speed. The theories exploited to design the motors are thoroughly explained while the comparison of the performance is made on results from both analytical and finite element analysis (FEA). The work is validated using a small experimental setup to launch a UAV weighing 4.5 kg. The electromagnetic analysis developed for civil aircraft launchers has been employed to size the scaled down motors and the methods proposed to design all the other components of the test rig are also presented.

Electromagnetic launch systems have been proposed for military applications to accelerate jet planes on aircraft carriers. This paper proposes the implementation of similar technology to aid civil aircraft take-off, which can provide significant economic, environmental and technical benefits. Assisted launch has the potential of reducing on ground noise and emissions near airports and improving overall aircraft efficiency through reducing engine thrust requirements. This paper presents a take-off performance analysis for an Airbus A320-200 taking off with and without the assistance of the electromagnetic catapult. Assisted take-off allows for a significant reduction in take-off field length, giving more capacity with existing airport footprints and reducing the necessary footprint of new airports, which will both reduce costs and increase the number of suitable sites. The electromagnetic catapult may allow the installation of smaller engines with lower rated thrust. The consequent fuel consumption and operational cost reduction is estimated. The potential of reducing the aircraft operational costs and the runway length required make electromagnetic launch system an attractive solution to the air traffic growth in busy airports.

The engine size of modern passenger transport aircraft is principally determined by take-off conditions, since initial acceleration requires maximum engine power. An Electromagnetic Launch (EML) system could provide some or all of the energy required at the launch stage so that the aircraft engine power requirement and fuel consumption may be significantly reduced. So far, EML for aircraft has been adopted only for military applications to replace steam catapults on the deck of aircraft carriers. This paper will describe the application of EML to propel civil aircraft on the runways of modern airports. A comparison of synchronous and asynchronous electrical motor systems designed to launch an A320-200 will be presented. The paper will present the solution of the transient heat transfer problem of EML systems and the respective design limitations of a civil aircraft launcher under rated current density. The experimental setup that will serve for future validation is introduced.

This paper compares three possible linear motor topologies for an electromagnetic launch system to assist civil aircraft take-off. Assisted launch of civil aircraft has the potential of reducing the required runway length, reducing noise and emissions near airports and improving overall aircraft efficiency through reducing engine thrust requirements. A comparison is made of practical designs of a linear induction motor, a linear permanent magnet synchronous motor and a superconducting linear synchronous motor to propel the A320-200 aircraft. The machine design requirements are established considering aerodynamic and engine performance and allow the aircraft to safely complete the take-off procedure. Analytical design of conventional synchronous and asynchronous linear motor will be compared with finite element analysis. A superconducting synchronous motor design is also considered, accounting for full system losses including the cryocooler power requirement and the mechanical & design constraints necessary for the cooler and the superconducting coils