738 results on '"Bertoglio P"'
Search Results
2. Dual-step pharmacological intervention for traumatic-like memories: implications from D-cycloserine and cannabidiol or clonidine in male and female rats
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Soares, Luciane A., Nascimento, Laura M. M., Guimarães, Francisco S., Gazarini, Lucas, and Bertoglio, Leandro J.
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- 2024
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3. Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease
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Zajicek, Franziska, Verhaeghe, Jeroen, De Lombaerde, Stef, Van Eetveldt, Annemie, Miranda, Alan, Munoz-Sanjuan, Ignacio, Dominguez, Celia, Khetarpal, Vinod, Bard, Jonathan, Liu, Longbin, Staelens, Steven, and Bertoglio, Daniele
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- 2024
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4. Shadow Blade: A tool to interact with attack vectors
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Ril, Ariel R., Bertoglio, Daniel Dalalana, and Zorzo, Avelino F.
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Computer Science - Cryptography and Security - Abstract
The increased demand of cyber security professionals has also increased the development of new platforms and tools that help those professionals to improve their offensive skills. One of these platforms is HackTheBox, an online cyber security training platform that delivers a controlled and safe environment for those professionals to explore virtual machines in a Capture the Flag (CTF) competition style. Most of the tools used in a CTF, or even on real-world Penetration Testing (Pentest), were developed for specific reasons so each tool usually has different input and output formats. These different formats make it hard for cyber security professionals and CTF competitors to develop an attack graph. In order to help cyber security professionals and CTF competitors to discover, select and exploit an attack vector, this paper presents Shadow Blade, a tool to aid users to interact with their attack vectors.
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- 2024
5. Towards new challenges of modern Pentest
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Bertoglio, Daniel Dalalana, Gil, Arthur, Acosta, Juan, Godoy, Julia, Lunardi, Roben Castagna, and Zorzo, Avelino Francisco
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Computer Science - Cryptography and Security - Abstract
With the increasing number of internet-based resources and applications, the amount of attacks faced by companies has increased significantly in the past years. Likewise, the techniques to test security and emulate attacks need to be constantly improved and, as a consequence, help to mitigate attacks. Among these techniques, penetration test (Pentest) provides methods to assess the security posture of assets, using different tools and methodologies applied in specific scenarios. Therefore, this study aims to present current methodologies, tools, and potential challenges applied to Pentest from an updated systematic literature review. As a result, this work provides a new perspective on the scenarios where penetration tests are performed. Also, it presents new challenges such as automation of techniques, management of costs associated with offensive security, and the difficulty in hiring qualified professionals to perform Pentest., Comment: 11 pages, 2 figures. Paper presented at World Conference on Smart Trends in Systems, Security, and Sustainability (WorldS4 2023)
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- 2023
6. Two-meshes approach in posterior component separation with transversus abdominis release: the IMPACT study (Italian Multicentric Posterior-separation Abdominal Complex hernia Transversus-release)
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Pizza, F, Maida, P, Bertoglio, C, Antinori, A, Mongardini, F M, Cerbara, L, Sordelli, I, Alampi, B D, Marte, G, Morini, L, Grimaldi, S, Gili, S, Docimo, L, and Gambardella, C
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- 2024
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7. Load Reduction Leadership: A Cognitive Load Theory-Based Framework Differentiating Performance Patterns in NYC Schools
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Kristopher C. Bertoglio
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This dissertation applies cognitive load theory to teacher working conditions in New York City. To connect small-scale cognitive processes with perennial organization-level effects, the theoretical components of this paper develop a novel framework. Load reduction leadership (LRL) illuminates how day-to-day school operations impact staff members' cognition and school-level student performance. LRL extrapolates various cognitive load phenomena to schools' complexities and time scales. Eight longitudinal case studies were found through New York State summative exam data. Schools were selected based on their abilities to over- and under-perform at improving their students' proficiency, including schools that changed from under- to over-performance and vice versa. Public documents provided samples of organizational practices during each performance period, which were analyzed using LRL. The ratio of LRL-aligned to -misaligned coding's differentiated between samples taken from periods of over- and under-performance. Three exceptional former New York City principals from different schools were interviewed. Those transcripts provided further insight into the framework's potential to explain mechanisms linking school leaders' actions to school-wide performance. These quantitative and qualitative explorations generate recommendations for school improvement practices and future research. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
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- 2024
8. A Map-Free LiDAR-Based System for Autonomous Navigation in Vineyards
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Bertoglio, Riccardo, Carini, Veronica, Arrigoni, Stefano, and Matteucci, Matteo
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Computer Science - Robotics - Abstract
Agricultural robots have the potential to increase production yields and reduce costs by performing repetitive and time-consuming tasks. However, for robots to be effective, they must be able to navigate autonomously in fields or orchards without human intervention. In this paper, we introduce a navigation system that utilizes LiDAR and wheel encoder sensors for in-row, turn, and end-row navigation in row structured agricultural environments, such as vineyards. Our approach exploits the simple and precise geometrical structure of plants organized in parallel rows. We tested our system in both simulated and real environments, and the results demonstrate the effectiveness of our approach in achieving accurate and robust navigation. Our navigation system achieves mean displacement errors from the center line of 0.049 m and 0.372 m for in-row navigation in the simulated and real environments, respectively. In addition, we developed an end-row points detection that allows end-row navigation in vineyards, a task often ignored by most works.
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- 2023
9. Surgical fine-tuning for Grape Bunch Segmentation under Visual Domain Shifts
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Chiatti, Agnese, Bertoglio, Riccardo, Catalano, Nico, Gatti, Matteo, and Matteucci, Matteo
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Computer Science - Robotics ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Mobile robots will play a crucial role in the transition towards sustainable agriculture. To autonomously and effectively monitor the state of plants, robots ought to be equipped with visual perception capabilities that are robust to the rapid changes that characterise agricultural settings. In this paper, we focus on the challenging task of segmenting grape bunches from images collected by mobile robots in vineyards. In this context, we present the first study that applies surgical fine-tuning to instance segmentation tasks. We show how selectively tuning only specific model layers can support the adaptation of pre-trained Deep Learning models to newly-collected grape images that introduce visual domain shifts, while also substantially reducing the number of tuned parameters.
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- 2023
10. Prokaryotic richness and diversity increased during Holocene glacier retreat and onset of an Antarctic Lake
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Piccini, C., Bertoglio, F., Sommaruga, R., Martínez de la Escalera, G., Pérez, L., Bugoni, L., Bergamino, L., Evangelista, H., and García-Rodriguez, F.
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- 2024
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11. O USO DE PROPIONATO DE CLOBETASOL NA CICATRIZAÇÃO DE FERIDAS: REVISÃO INTEGRATIVA
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RONIVALDO PINTO FERREIRA, Rafaela Bertoglio Escher, Natalia de Sá Policarpo, Gustavo Henrique Pereira Pinto, and Heloísa Geovana dos Santos Pinto
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Clobetasol ,Cicatrização ,Corticoide ,Ferimentos e Lesões ,Inflamação. ,Nursing ,RT1-120 - Abstract
Objetivo: identificar os efeitos e aplicação do propionato de clobetasol na cicatrização de feridas em humanos, e em quais feridas é mais frequente o uso dessa corticoideterapia tópica. Método: revisão integrativa, com a estratégia PICO, realizada entre janeiro e março de 2024 nas bases de dados U.S National Library of Medicine (PubMed), Cochrane Library, Scientific Electronic Library Online (SciELO) e no Google Acadêmico. Utilizou-se o seguinte algoritmo de busca: “Clobetasol” AND “Wound Healing” AND “Patients” com recorte temporal de 10 anos. Resultados: foram encontrados 1939 estudos, sendo selecionados 18 para a revisão. A maioria foi do tipo relato de caso. O tipo de ferida mais prevalente foi o pioderma gangrenoso ulcerativo, sendo a aplicação do clobetasol duas vezes na semana por até 14 dias. Os efeitos com uso do medicamento foram a diminuição dos sinais de inflamação e resolução na cicatrização das feridas. Conclusão: os dados sugerem que a aplicação tópica do propionato de clobetasol, em conjunto com outras terapias, em humanos portadores de feridas do tipo pioderma gangrenoso, penfigoide bolhoso, hipergranulação, queimaduras, dermatoses e líquen escleroso promove melhoras no processo cicatricial.
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- 2024
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12. Deaths in jail: a retrospective analysis of autopsies performed at the Legal Medicine Unit of Pavia (1999-2022)
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Giacomo Belli, Mateus E. Romão, Riccardo Lacquagni, Barbara Bertoglio, Andrea Bertolotti, Gaia Tamellini, Luca Morini, Gulnaz T. Javan, Ilaria Setti, and Silvia D. Visonà
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death in custody ,detention regime ,safety in prison ,suicide prevention ,inmates ,Psychiatry ,RC435-571 - Abstract
IntroductionThe high rate of incarceration, now exceeding 11.5 million people worldwide, has raised concerns about the conditions within penal institutions, such as the consequences of incarceration on the person. This retrospective study aims to investigate the issue of death in custody, exploring the relationship between incarceration, health vulnerabilities, and death from the forensic pathologist’s point of view.MethodsWe analyzed, from a forensic, clinical and toxicological perspective, 86 cases of deaths in detention facilities in North-Western Italy from 1999 to 2022.ResultsThe analysis has shown that suicide, mainly committed by hanging, plastic bag suffocation and butane intoxication, represents the leading type of violent death (52%), followed by accidental deaths (16%). On the other hand, cardiovascular diseases are the leading cause of natural deaths (42%), followed by infectious diseases (especially HIV-related).DiscussionThe present study identifies the most frequent and critical situations and risk factors related to death in custody and the profile of the inmate who is at a higher risk of death, allowing to highlight the issues to be addressed from a public health point of view. On the whole, it calls for comprehensive reforms, aligned with international human rights standards, addressing mental and physical care gaps, improving correctional officers' education, and training, and focusing on rehabilitation with well-being and dignity.
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- 2024
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13. Prokaryotic richness and diversity increased during Holocene glacier retreat and onset of an Antarctic Lake
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C. Piccini, F. Bertoglio, R. Sommaruga, G. Martínez de la Escalera, L. Pérez, L. Bugoni, L. Bergamino, H. Evangelista, and F. García-Rodriguez
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Geology ,QE1-996.5 ,Environmental sciences ,GE1-350 - Abstract
Abstract Knowledge about biodiversity changes during transitions from glacial landscape to lake formation is limited to contemporary studies. Here, we combined analyses of lithology, chronology and geochemistry with sedimentary ancient DNA metabarcoding to assess such transition in maritime Antarctica. We inferred three paleoenvironmental stages covering the Holocene glacier retreat process. From 4900 to 3850 years before the present, we found the lowest prokaryotic richness/diversity, with bacterial taxa indicators associated to soil and terrestrial environments. From 3850 to 2650 years before the present, a higher carbon content, higher Carbon/Nitrogen variability, increased species richness/diversity, and prokaryotic taxa indicators of long-term energy starvation were detected. Finally, from 2650 to 1070 years before the present, we inferred the onset of a genuine lacustrine environment holding stable Carbon/Nitrogen ratios and the highest prokaryotic diversity, with known aquatic bacterial taxa. Our study unveils for the first time the evolution from a glacier-covered to a freshwater lake through a millennial scale.
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- 2024
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14. A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants
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Kristin Metzdorf, Henning Jacobsen, Yeonsu Kim, Luiz Gustavo Teixeira Alves, Upasana Kulkarni, Maja Cokarić Brdovčak, Jelena Materljan, Kathrin Eschke, M. Zeeshan Chaudhry, Markus Hoffmann, Federico Bertoglio, Maximilian Ruschig, Michael Hust, Marko Šustić, Astrid Krmpotić, Stipan Jonjić, Marek Widera, Sandra Ciesek, Stefan Pöhlmann, Markus Landthaler, and Luka Čičin-Šain
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SARS-CoV-2 ,COVID-19 ,MCMV ,vaccination ,single-dose ,long-lasting protection ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Current vaccines against COVID-19 elicit immune responses that are overall strong but wane rapidly. As a consequence, the necessary booster shots have contributed to vaccine fatigue. Hence, vaccines that would provide lasting protection against COVID-19 are needed, but are still unavailable. Cytomegaloviruses (CMVs) elicit lasting and uniquely strong immune responses. Used as vaccine vectors, they may be attractive tools that obviate the need for boosters. Therefore, we tested the murine CMV (MCMV) as a vaccine vector against COVID-19 in relevant preclinical models of immunization and challenge. We have previously developed a recombinant MCMV vaccine vector expressing the spike protein of the ancestral SARS-CoV-2 (MCMVS). In this study, we show that the MCMVS elicits a robust and lasting protection in young and aged mice. Notably, spike-specific humoral and cellular immunity was not only maintained but also even increased over a period of at least 6 months. During that time, antibody avidity continuously increased and expanded in breadth, resulting in neutralization of genetically distant variants, like Omicron BA.1. A single dose of MCMVS conferred rapid virus clearance upon challenge. Moreover, MCMVS vaccination controlled two variants of concern (VOCs), the Beta (B.1.135) and the Omicron (BA.1) variants. Thus, CMV vectors provide unique advantages over other vaccine technologies, eliciting broadly reactive and long-lasting immune responses against COVID-19.
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- 2024
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15. Prolonged Impella 5.0/5.5 support within different pathways of care for cardiogenic shock: the experience of a referral center
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Marina Pieri, Alessandro Ortalda, Savino Altizio, Luca Bertoglio, Pasquale Nardelli, Evgeny Fominskiy, Elisabetta Lapenna, Silvia Ajello, and Anna Mara Scandroglio
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mechanical circulatory support ,cardiogenic shock ,Impella ,myocardial recovery ,LVAD ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
AimsImpella 5.0 and 5.5 are promising low-invasive left ventricle (LV) temporary mechanical circulatory supports (tMCS) for cardiogenic shock due to LV mechanical unloading and are paired with powerful hemodynamic support. This study aimed to analyze data and destinies of patients supported with Impella 5.0/5.5 at a national referral center for cardiogenic shock and to assess the parameters associated with myocardial recovery and successful weaning.MethodsA single-center observational study was conducted on all patients treated with Impella 5.0 or 5.5 from March 2018 to July 2023.ResultsA total of 59 patients underwent Impella 5.0/5.5 implantation due to profound cardiogenic shock, with acute myocardial infarction being the most frequent cause of shock (42 patients, 71%). The median duration of Impella support was 13 days (maximum duration of 52 days). Axillary cannulation was feasible in almost all patients, and 36% were mobilized during support. A total of 44 patients (75%) survived to the next therapy/recovery: 21 patients experienced recovery and 15 and 8 were bridged to long-term LVAD and heart transplantation, respectively. The global survival rate was 66%. The predictors of native heart recovery at multivariate analysis were the number of days on tMCS before upgrade to Impella 5.0/5.5 [hazard ratio (HR) 0.68 (0.51–9) p = 0.0068] and improvement of LVEF within the first 7–10 days of support [HR 4.72 (1.34–16.7), p = 0.016].ConclusionsTranscatheter systems such as Impella 5.0/5.5 revolutionized the field of tMCS. Myocardial recovery is the primary clinical target. Its prognostication and promotion are key to ensure the most proficuous course for each patient from cardiogenic shock to long-term event-free survival.
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- 2024
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16. Early Postoperative Results after Thymectomy for Thymic Cancer: A Single-Institution Experience
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Petroncini, Matteo, Solli, Piergiorgio, Brandolini, Jury, Lai, Giulia, Antonacci, Filippo, Garelli, Elena, Kawamukai, Kenji, Forti Parri, Sergio Nicola, Bonfanti, Barbara, Dolci, Giampiero, and Bertoglio, Pietro
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- 2023
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17. Activity of Brevibacillus brevis strain LABIM17 against Xanthomonas euvesicatoria pv. euvesicatoria and control of bacterial spot of tomato
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Bertoglio, Caroline, Moura Duin, Izabela, Bertê, Rosiana, Manoel Teixeira, Gustavo, Gonçalves de Oliveira, Admilton, Pereira Leite, Jr, Rui, and Balbi-Peña, Maria Isabel
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- 2023
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18. A postmortem case control study of asbestos burden in lungs of malignant mesothelioma cases
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S. D. Visonà, B. Bertoglio, C. Favaron, S. Capella, E. Belluso, C. Colosio, S. Villani, T. Ivic-Pavlicic, and E. Taioli
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Malignant mesothelioma ,Asbestos ,SEM–EDS ,Autopsy ,Chrysotile ,Amphiboles ,Medicine - Abstract
Abstract Background Asbestos lung content is regarded as the most reliable tool for causal attribution of malignant mesothelioma (MM) to previous asbestos exposures. However, there is a lack of studies on asbestos burden in lungs of MM patients in comparison with healthy individuals. This study aims to provide such a comparison, investigating, as well, differences in asbestos lung burden with sex and time trends. Methods Asbestos lung content has been assessed on formalin-fixed lung fragments using scanning electron microscopy coupled with energy dispersion spectroscopy (SEM–EDS) on individuals deceased from MM (cases) and healthy subjects without any lung disease who died from violent causes (controls) between 2005 and 2023. Results Asbestos and asbestos bodies (ABs) were found, respectively, in 73.7% and 43.2% of cases and in 28 and 22% of controls; in MM cases the most represented asbestos types were crocidolite and amosite, whereas in controls it was tremolite-actinolite asbestos. The concentration of both asbestos fibers and ABs was statistically significantly higher in MM cases compared to controls. The mean asbestos fibers width was also significantly higher in cases than controls. Males and females with MM showed similar asbestos and ABs concentrations, but females had higher concentrations of chrysotile, and significantly lower fibers width compared to males. Time trends show that MM lung asbestos concentrations decreased starting in 2011. Discussion The results suggest a correlation between asbestos burden in lungs and MM risk. The different concentration of chrysotile, as well as the different width of asbestos fibers in MM males and females might reflect a sex difference in response of the lung microenvironment to inhaled asbestos. Finally, this study provides the first pathological evidence of the effect of the ban of asbestos use, demonstrating a significant decrease of asbestos lung content after 2011.
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- 2023
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19. Accurate image derived input function in [18F]SynVesT-1 mouse studies using isoflurane and ketamine/xylazine anesthesia
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Alan Miranda, Daniele Bertoglio, Steven Staelens, and Jeroen Verhaeghe
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Mouse ,[18F]SynVesT-1 ,Image derived input function ,Non-negative matrix factorization ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background Kinetic modeling in positron emission tomography (PET) requires measurement of the tracer plasma activity in the absence of a suitable reference region. To avoid invasive blood sampling, the use of an image derived input function has been proposed. However, an accurate delineation of the blood pool region in the PET image is necessary to obtain unbiased blood activity. Here, to perform brain kinetic modeling in [18F]SynVesT-1 dynamic scans, we make use of non-negative matrix factorization (NMF) to unmix the activity signal from the different tissues that can contribute to the heart region activity, and extract only the left ventricle activity in an unbiased way. This method was implemented in dynamic [18F]SynVesT-1 scans of mice anesthetized with either isoflurane or ketamine–xylazine, two anesthestics that we showed to affect differently radiotracer kinetics. The left ventricle activity (NMF-IDIF) and a manually delineated cardiac activity (IDIF) were compared with arterial blood samples (ABS), and for isoflurane anesthetized mice, arteriovenous (AV) shunt blood data were compared as well. Finally, brain regional 2 tissue compartment modeling was performed using IDIF and NMF-IDIF, and the model fit accuracy (weighted symmetrical mean absolute percentage error, wsMAPE) as well as the total volume of distribution (V T) were compared. Results In isoflurane anesthetized mice, the difference between ABS and NMF-IDIF activity (+ 12.8 $$\pm$$ ± 11%, p = 0.0023) was smaller than with IDIF (+ 16.4 $$\pm$$ ± 9.8%, p = 0.0008). For ketamine–xylazine anesthetized mice the reduction in difference was larger (NMF-IDIF: 16.9 $$\pm$$ ± 10%, p = 0.0057, IDIF: 56.3 $$\pm$$ ± 14%, p
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- 2023
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20. Accurate image derived input function in [18F]SynVesT-1 mouse studies using isoflurane and ketamine/xylazine anesthesia
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Miranda, Alan, Bertoglio, Daniele, Staelens, Steven, and Verhaeghe, Jeroen
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- 2023
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21. A postmortem case control study of asbestos burden in lungs of malignant mesothelioma cases
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Visonà, S. D., Bertoglio, B., Favaron, C., Capella, S., Belluso, E., Colosio, C., Villani, S., Ivic-Pavlicic, T., and Taioli, E.
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- 2023
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22. Influence of the Mn5Ge3/Ge ohmic-contact interface on the Seebeck coefficient of the Mn5Ge3/Ge bilayer
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Portavoce, Alain, Hassak, Siham, and Bertoglio, Maxime
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- 2023
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23. Comparison of COVID-19 hospitalization costs across care pathways: a patient-level time-driven activity-based costing analysis in a Brazilian hospital
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Cardoso, Ricardo Bertoglio, Marcolino, Miriam Allein Zago, Marcolino, Milena Soriano, Fortis, Camila Felix, Moreira, Leila Beltrami, Coutinho, Ana Paula, Clausell, Nadine Oliveira, Nabi, Junaid, Kaplan, Robert S., Etges, Ana Paula Beck da Silva, and Polanczyk, Carisi Anne
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- 2023
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24. Impact of the COVID-19 pandemic on the mental health of frontline healthcare workers in a highly affected region in Brazil
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Cohen, Mírian, Cruz, Luciane Nascimento, Cardoso, Ricardo Bertoglio, Albuquerque, Maria de Fátima Pessoa Militão de, Montarroyos, Ulisses Ramos, de Souza, Wayner Vieira, Ludermir, Ana Bernarda, de Carvalho, Maria Rosimery, da Silva Vicente, Julianne Damiana, Viegas Filho, Marcelo Paulino, Cortes, Fanny Julia Mireille, de Siqueira Silva, Marina Teixeira, Almeida, Carla Menezes Cavalcante, Lima, Luana Nepomuceno Gondim Costa, Veras, Maria Amelia de Sousa Mascena, Kendall, Carl, Kerr, Ligia Regina Franco Sansigolo, Martelli, Celina Maria Turchi, and Camey, Suzi Alves
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- 2023
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25. Magnetic moment impact on spin-dependent Seebeck coefficient of ferromagnetic thin films
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Portavoce, Alain, Assaf, Elie, Bertoglio, Maxime, Narducci, Dario, and Bertaina, Sylvain
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- 2023
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26. Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington's disease
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Nicholas Vidas-Guscic, Joëlle van Rijswijk, Johan Van Audekerke, Ben Jeurissen, Israel Nnah, Haiying Tang, Ignacio Muñoz-Sanjuan, Dorian Pustina, Roger Cachope, Annemie Van der Linden, Daniele Bertoglio, and Marleen Verhoye
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Fixel-based analysis ,Neurodegeneration ,Huntington's disease ,Longitudinal ,Preclinical ,Neurofilament ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Huntington's disease (HD) is a progressive neurodegenerative disease affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans and animal models of HD. The identification of sensitive white-matter-based biomarkers in HD animal models will be important in understanding disease mechanisms and testing the efficacy of therapeutic interventions. Here we investigated the progression of white matter deficits in the knock-in zQ175DN heterozygous (HET) mouse model of HD at 3, 6 and 11 months of age (M), reflecting different states of phenotypic progression. We compared findings from traditional diffusion tensor imaging (DTI) and advanced fixel-based analysis (FBA) diffusion metrics for their sensitivity in detecting white matter anomalies in the striatum, motor cortex, and segments of the corpus callosum. FBA metrics revealed progressive and widespread reductions of fiber cross-section and fiber density in myelinated bundles of HET mice. The corpus callosum genu was the most affected structure in HET mice at 6 and 11 M based on the DTI and FBA metrics, while the striatum showed the earliest progressive differences starting at 3 M based on the FBA metrics. Overall, FBA metrics detected earlier and more prominent alterations in myelinated fiber bundles compared to the DTI metrics. Luxol fast blue staining showed no loss in myelin density, indicating that diffusion anomalies could not be explained by myelin reduction but diffusion anomalies in HET mice were accompanied by increased levels of neurofilament light chain protein at 11 M. Altogether, our findings reveal progressive alterations in myelinated fiber bundles that can be measured using diffusion MRI, representing a candidate noninvasive imaging biomarker to study phenotype progression and the efficacy of therapeutic interventions in zQ175DN mice. Moreover, our study exposed higher sensitivity of FBA than DTI metrics, suggesting a potential benefit of adopting these advanced metrics in other contexts, including biomarker development in humans.
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- 2024
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27. Connecting Large-Scale Velocity and Temperature Bursts with Small-Scale Intermittency in Stratified Turbulence
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Feraco, Fabio, Marino, Raffaele, Primavera, Leonardo, Pumir, Alain, Mininni, Pablo, Rosenberg, Duane, Pouquet, Annick, Foldes, Raffaello, Lévêque, Emmanuel, Camporeale, Enrico, Cerri, Silvio, Asokan, Harikrishnan Charuvil, Chau, Jorge, Bertoglio, Jean-Pierre, Salizzoni, Pietro, and Marro, Massimo
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Physics - Fluid Dynamics - Abstract
Non-Gaussian statistics of large-scale fields are routinely observed in data from atmospheric and oceanic campaigns and global models. Recent direct numerical simulations (DNSs) showed that large-scale intermittency in stably stratified flows is due to the emergence of sporadic, extreme events in the form of bursts in the vertical velocity and the temperature. This phenomenon results from the interplay between waves and turbulent motions, affecting mixing. We provide evidence of the enhancement of the classical small-scale (or internal) intermittency due to the emergence of large-scale drafts, connecting large- and small-scale bursts. To this aim we analyze a large set of DNSs of the stably stratified Boussinesq equations over a wide range of values of the Froude number ($Fr\approx 0.01-1$). The variation of the buoyancy field kurtosis with $Fr$ is similar to (though with smaller values than) the kurtosis of the vertical velocity, both showing a non-monotonic trend. We present a mechanism for the generation of extreme vertical drafts and vorticity enhancements which follows from the exact equations for field gradients., Comment: 7 pages, 4 figures
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- 2021
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28. Influence of the Mn5Ge3/Ge ohmic-contact interface on the Seebeck coefficient of the Mn5Ge3/Ge bilayer
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Alain Portavoce, Siham Hassak, and Maxime Bertoglio
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Medicine ,Science - Abstract
Abstract Thermoelectricity is a well-known effect that can be used to convert heat energy into electrical energy. However, the yield of this conversion is still low compared to current photovoltaic technology. It is limited by the intrinsic properties of materials, leading to intensive materials science investigations for the design of efficient thermoelectric (TE) materials. Interface engineering was shown to be a valuable solution for improving materials’ TE properties, supporting the development of multiphase TE materials. In particular, interfaces have been suggested to promote the increase of the Seebeck coefficient of materials without significantly impacting their electrical conductivity through the so-called energy filtering effect. This work aims at determining experimentally the effect of a metal/semiconductor interface exhibiting an ohmic character on the effective Seebeck coefficient of multiphase materials, focusing on the n-type Mn5Ge3/p-type Ge interface. This interface is shown not to contribute to carrier transport, but to contribute to carrier concentration filtering due to carrier injection or recombination. The Seebeck coefficient of the bi-phase material is shown to be dependent on the direction carriers are crossing the interface. The interface effect mainly results from a modification of charge carrier concentrations in the semiconductor.
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- 2023
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29. A parametric geometry model of the aortic valve for subject-specific blood flow simulations using a resistive approach
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Pase, Giorgia, Brinkhuis, Emiel, De Vries, Tanja, Kosinka, Jiří, Willems, Tineke, and Bertoglio, Cristóbal
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- 2023
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30. The Digital Agricultural Revolution: a Bibliometric Analysis Literature Review
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Bertoglio, Riccardo, Corbo, Chiara, Renga, Filippo M., and Matteucci, Matteo
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Computer Science - Digital Libraries - Abstract
The application of digital technologies in agriculture can improve traditional practices to adapt to climate change, reduce Greenhouse Gases (GHG) emissions, and promote a sustainable intensification for food security. Some authors argued that we are experiencing a Digital Agricultural Revolution (DAR) that will boost sustainable farming. This study aims to find evidence of the ongoing DAR process and clarify its roots, what it means, and where it is heading. We investigated the scientific literature with bibliometric analysis tools to produce an objective and reproducible literature review. We retrieved 4995 articles by querying the Web of Science database in the timespan 2012-2019, and we analyzed the obtained dataset to answer three specific research questions: i) what is the spectrum of the DAR-related terminology?; ii) what are the key articles and the most influential journals, institutions, and countries?; iii) what are the main research streams and the emerging topics? By grouping the authors' keywords reported on publications, we identified five main research streams: Climate-Smart Agriculture (CSA), Site-Specific Management (SSM), Remote Sensing (RS), Internet of Things (IoT), and Artificial Intelligence (AI). To provide a broad overview of each of these topics, we analyzed relevant review articles, and we present here the main achievements and the ongoing challenges. Finally, we showed the trending topics of the last three years (2017, 2018, 2019).
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- 2021
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31. Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?
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Michele Mazzola, Lorenzo Ripamonti, Alessandro Giani, Pietro Carnevali, Matteo Origi, BrunocDomenico Alampi, Irene Giusti, Pietro Achilli, Camillo Leonardo Bertoglio, Carmelo Magistro, and Giovanni Ferrari
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complete mesocolic excision ,laparoscopic surgery ,right colectomy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Despite its potential oncologic benefit, complete mesocolic excision (CME) has rarely been offered to elderly patients. The present study evaluated the effect of age on postoperative outcomes among patients undergoing laparoscopic right colectomies with CME for right-sided colon cancer (RCC). Methods: Data of patients undergoing laparoscopic right colectomies with CME for RCC between 2015 and 2018 were retrospectively analyzed. Selected patients were divided into two groups: the under-80 group and the over-80 group. Surgical, pathological, and oncological outcomes among the groups were compared. Results: A total of 130 patients were selected (95 in the under-80 group and 35 in the over-80 group). No difference was found between the groups in terms of postoperative outcomes, except for median length of stay and adjuvant chemotherapy received, which were in favor of the under-80 group (5 vs. 8 days, p < 0.001 and 26.3% vs. 2.9%, p = 0.003, respectively). No difference between the groups was found regarding overall survival and disease free survival. Using multivariate analysis, only the ASA score > 2 (p = 0.01) was an independent predictor of overall complications. Conclusions: laparoscopic right colectomy with CME for RCC was safely performed in elderly patients ensuring similar oncological outcomes compared to younger patients.
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- 2023
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32. The effect of pulsed electromagnetic field exposure on osteoinduction of human mesenchymal stem cells cultured on nano-$TiO_{2}$ surfaces
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Bloise, Nora, Petecchia, Loredana, Ceccarelli, Gabriele, Fassina, Lorenzo, Usai, Cesare, Bertoglio, Federico, Balli, Martina, Vassalli, Massimo, De Angelis, Maria Gabriella Cusella, Gavazzo, Paola, Imbriani, Marcello, and Visai, Livia
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Quantitative Biology - Quantitative Methods ,Quantitative Biology - Tissues and Organs - Abstract
Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are considered a great promise in the repair and regeneration of bone. Considerable efforts have been oriented towards uncovering the best strategy to promote stem cells osteogenic differentiation. In previous studies, hBM-MSCs exposed to physical stimuli such as pulsed electromagnetic fields (PEMFs) or directly seeded on nanostructured titanium surfaces ($TiO_{2}$) were shown to improve their differentiation to osteoblasts in osteogenic condition. In the present study, the effect of a daily PEMF-exposure on osteogenic differentiation of hBM-MSCs seeded onto nanostructured $TiO_{2}$ (with clusters under 100 nm of dimension) was investigated. $TiO_{2}$-seeded cells were exposed to PEMF (magnetic field intensity: 2 mT; intensity of induced electric field: 5 mV; frequency: 75 Hz) and examined in terms of cell physiology modifications and osteogenic differentiation. Results showed that PEMF exposure affected $TiO_{2}$-seeded cells osteogenesis by interfering with selective calcium-related osteogenic pathways, and greatly enhanced hBM-MSCs osteogenic features such as the expression of early/late osteogenic genes and protein production (e.g., ALP, COL-I, osteocalcin and osteopontin) and ALP activity. Finally, PEMF-treated cells resulted to secrete into conditioned media higher amounts of BMP-2, DCN and COL-I than untreated cell cultures. These findings confirm once more the osteoinductive potential of PEMF, suggesting that its combination with $TiO_{2}$ nanostructured surface might be a great option in bone tissue engineering applications.
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- 2020
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33. 10th antibody industrial symposium: new developments in antibody and adoptive cell therapies
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Ana Antunes, Luis Alvarez-Vallina, Federico Bertoglio, Nicolas Bouquin, Stéphanie Cornen, Francis Duffieux, Pierre Ferré, Raphaëlle Gillet, Christian Jorgensen, Mark B Leick, Bernard Maillère, Hélène Negre, Mireia Pelegrin, Nicolas Poirier, Dietmar Reusch, Bruno Robert, Guy Serre, Alain Vicari, Martin Villalba, Christoph Volpers, Gavin Vuddamalay, Hervé Watier, Thierry Wurch, Lennart Zabeau, Stefan Zielonka, Baolin Zhang, Alain Beck, and Pierre Martineau
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Antibody engineering ,Antibody industrial symposium ,antibody-related molecules ,biotherapeutics ,cell-based therapies ,congress ,Therapeutics. Pharmacology ,RM1-950 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
ABSTRACTThe annual “Antibody Industrial Symposium”, co-organized by LabEx MAbImprove and MabDesign, held its 10th anniversary edition in Montpellier, France, on June 28–29, 2022. The meeting focused on new results and concepts in antibody engineering (naked, mono- or multi-specific, conjugated to drugs or radioelements) and also on new cell-based therapies, such as chimeric antigenic receptor (CAR)-T cells. The symposium, which brought together scientists from academia and industry, also addressed issues concerning the production of these molecules and cells, and the necessary steps to ensure a strong intellectual property protection of these new molecules and approaches. These two days of exchanges allowed a rich discussion among the various actors in the field of therapeutic antibodies.
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- 2023
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34. Pentest on an Internet Mobile App: A Case Study using Tramonto
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Bertoglio, Daniel Dalalana, Girotto, Guilherme, Neu, Charles Varlei, Lunardi, Roben Castagna, and Zorzo, and Avelino Francisco
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Computer Science - Cryptography and Security - Abstract
Mobile applications are used to handle different types of data. Commonly, there is a set of personal identifiable information present in the data stored, shared and used by these applications. From that, attackers can try to exploit the mobile application in order to obtain or to cause private data leakage. Therefore, performing security assessments is an important practice to find vulnerabilities in the applications and systems before the application is deployed, or even during their use. Regarding security assessments, Penetration Test (Pentest) is one of the security test types that can be used to detect vulnerabilities through simulated attacks. Additionally, Pentest can be performed using different methodologies and best practices, through several frameworks to: organize the test execution, execute tools, provide estimations, provide reports and document a Pentest. One such framework is Tramonto, which aims to assist a cybersecurity expert during the Pentest execution by providing organization, standardization and flexibility to the whole Pentest process. This paper presents a Pentest case study applied to a Brazilian university Mobile App using the Tramonto framework. The main goal of this case study is to present how Tramonto can be applied during a Pentest execution, assisting cybersecurity experts in the tasks included in the Pentest process. Our results show details on how to perform a Pentest using Tramonto and the found vulnerabilities in the Mobile App. Besides that, there is a discussion about the main contributions obtained from our results, and we were able to verify that Tramonto managed, organized and optimized the whole Pentest process., Comment: ICITST 2019
- Published
- 2019
35. Impact of the COVID-19 pandemic on the mental health of frontline healthcare workers in a highly affected region in Brazil
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Mírian Cohen, Luciane Nascimento Cruz, Ricardo Bertoglio Cardoso, Maria de Fátima Pessoa Militão de Albuquerque, Ulisses Ramos Montarroyos, Wayner Vieira de Souza, Ana Bernarda Ludermir, Maria Rosimery de Carvalho, Julianne Damiana da Silva Vicente, Marcelo Paulino Viegas Filho, Fanny Julia Mireille Cortes, Marina Teixeira de Siqueira Silva, Carla Menezes Cavalcante Almeida, Luana Nepomuceno Gondim Costa Lima, Maria Amelia de Sousa Mascena Veras, Carl Kendall, Ligia Regina Franco Sansigolo Kerr, Celina Maria Turchi Martelli, and Suzi Alves Camey
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COVID-19 ,Mental health ,Healthcare workers ,Anxiety ,Depression ,PTSD. ,Psychiatry ,RC435-571 - Abstract
Abstract Background The COVID-19 pandemic had a major impact on the mental health of healthcare workers (HCWs), especially in low and middle-income countries, which had to face additional political, social, and economic challenges. We thus aimed to assess the prevalence of mental health outcomes and the associated factors in HCWs treating COVID-19 patients in one of the most affected regions in Brazil. Methods We used the Respondent-Driven Sampling method to assess the risks of COVID-19 infection and symptoms of mental disorders in nurses, nursing technicians, and physicians who worked on the frontline in the metropolitan region of Recife. 865 healthcare workers completed a survey regarding sociodemographic data, work-related risks, and symptoms of mental disorders - SRQ-20 for common mental disorders (CMD); AUDIT-C for problematic alcohol use; GAD-7 for anxiety; PHQ-9 for depression; PCL-5 for post-traumatic stress disorder (PTSD). Gile’s successive sampling estimator was used to produce the weighted estimates by professional category. A Poisson regression model with robust variance was used to analyze factors associated with a positive screening for CMD. We will present the results of a cross-sectional analysis of the mental health outcomes after the first peak of COVID-19 – from August 2020 to February 2021. Results The prevalence ratios for a positive screening for CMD were 34.9% (95% CI: 27.8–41.9) in nurses, 28.6% (95% CI: 21.3–36.0) in physicians, and 26.6% (95% CI: 16.8–36.5) in nursing technicians. Nurses presented a higher prevalence of depressive symptoms (23%). Positive screening for problematic alcohol use (10.5 to14.0%), anxiety (10.4 to 13.3%), and PTSD (3.3 to 4.4%) were similar between the professional categories. The main factors associated with CMD in nurses and physicians were related to an intrinsic susceptibility to mental illness, such as previous or family history of psychiatric disorder, and female sex. Among nurse technicians, work-related factors, such as accidents with biological material, presented the strongest association with CMD. Conclusion The mental health of HCWs fighting COVID-19 in Recife was severely affected. It is crucial that healthcare services provide adequate working conditions and psychological support, investing in programs to promote and protect HCWs mental health.
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- 2023
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36. Comparison of COVID-19 hospitalization costs across care pathways: a patient-level time-driven activity-based costing analysis in a Brazilian hospital
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Ricardo Bertoglio Cardoso, Miriam Allein Zago Marcolino, Milena Soriano Marcolino, Camila Felix Fortis, Leila Beltrami Moreira, Ana Paula Coutinho, Nadine Oliveira Clausell, Junaid Nabi, Robert S. Kaplan, Ana Paula Beck da Silva Etges, and Carisi Anne Polanczyk
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Cost and cost analysis ,Health care costs ,Microcosting ,Time-driven activity-based costing ,TDABC ,COVID-19 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The COVID-19 pandemic raised awareness of the need to better understand where and how patient-level costs are incurred in health care organizations, as health managers and other decision-makers need to plan and quickly adapt to the increasing demand for health care services to meet patients’ care needs. Time-driven activity-based costing offers a better understanding of the drivers of cost throughout the care pathway, providing information that can guide decisions on process improvement and resource optimization. This study aims to estimate COVID-19 patient-level hospital costs and to evaluate cost variability considering the in-hospital care pathways of COVID-19 management and the patient clinical classification. Methods This is a prospective cohort study that applied time-driven activity-based costing (TDABC) in a Brazilian reference center for COVID-19. Patients hospitalized during the first wave of the disease were selected for their data to be analyzed to estimate in-hospital costs. The cost information was calculated at the patient level and stratified by hospital care pathway and Ordinal Scale for Clinical Improvement (OSCI) category. Multivariable analyses were applied to identify predictors of cost variability in the care pathways that were evaluated. Results A total of 208 patients were included in the study. Patients followed five different care pathways, of which Emergency + Ward was the most followed (n = 118, 57%). Pathways which included the intensive care unit presented a statistically significant influence on costs per patient (p
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- 2023
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37. Standardized right artery first approach during laparoscopic pancreaticoduodenectomy for periampullary neoplasms: technical aspects and perioperative outcomes
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Mazzola, Michele, Giani, Alessandro, Bertoglio, Camillo Leonardo, Carnevali, Pietro, De Martini, Paolo, Benedetti, Antonio, Giusti, Irene, Magistro, Carmelo, and Ferrari, Giovanni
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- 2023
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38. The rights of migrants to the identification of their dead: an attempt at an identification strategy from Italy
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Cattaneo, Cristina, De Angelis, Danilo, Mazzarelli, Debora, Porta, Davide, Poppa, Pasquale, Caccia, Giulia, D’Amico, Maria Elisa, Siccardi, Cecilia, Previderè, Carlo, Bertoglio, Barbara, Tidball-Binz, Morris, Ubelaker, Douglas, Piscitelli, Vittorio, and Riccio, Silvana
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- 2023
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39. Is routine CT scan after pancreaticoduodenectomy a useful tool in the early detection of complications? A single center retrospective analysis
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Mazzola, Michele, Calcagno, Pietro, Giani, Alessandro, Maspero, Marianna, Bertoglio, Camillo Leonardo, De Martini, Paolo, Magistro, Carmelo, Sgrazzutti, Cristiano, Vanzulli, Angelo, and Ferrari, Giovanni
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- 2022
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40. The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples
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Pierangela Grignani, Silvia Damiana Visonà, Maria Vittoria Fronda, Paola Borrelli, Maria Cristina Monti, Barbara Bertoglio, Adelaide Conti, Paolo Fattorini, and Carlo Previderè
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asbestos ,malignant mesothelioma ,SNP ,single base extension (SBE) ,iron metabolism ,Public aspects of medicine ,RA1-1270 - Abstract
Asbestos-related diseases still represent a major public health problem all over the world. Among them, malignant mesothelioma (MM) is a poor-prognosis cancer, arising from the serosal lining of the pleura, pericardium and peritoneum, triggered by asbestos exposure. Literature data suggest the key role of iron metabolism in the coating process leading to the formation of asbestos bodies, considered to be both protective and harmful. Two sample sets of individuals were taken into consideration, both residing in Broni or neighboring cities (Northwestern Italy) where an asbestos cement factory was active between 1932 and 1993. The present study aims to compare the frequency of six SNPs involved in iron trafficking, previously found to be related to protection/predisposition to MM after asbestos exposure, between 48 male subjects with documented asbestos exposure who died of MM and 48 male subjects who were exposed to asbestos but did not develop MM or other neoplastic respiratory diseases (Non-Mesothelioma Asbestos Exposed – NMAE). The same analysis was performed on 76 healthy male controls. The allelic and genotypic frequencies of a sub-group of 107 healthy Italian individuals contained in the 1000 genomes database were considered for comparison. PCR-multiplex amplification followed by SNaPshot mini-sequencing reaction was used. The findings presented in this study show that the allelic and genotypic frequencies for six SNP markers involved in iron metabolism/homeostasis and the modulation of tumor microenvironment are not significantly different between the two sample sets of MM and NMAE. Therefore, the SNPs here considered do not seem to be useful markers for individual susceptibility to mesothelioma. This finding is not in agreement with previous literature.
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- 2023
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41. Editorial: Imaging brain molecular connectivity in health and disease
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Arianna Sala, Kristina Herfert, Gabriel Gonzalez-Escamilla, Silvia Paola Caminiti, and Daniele Bertoglio
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PET ,SPECT ,MRI ,system neuroscience ,metabolic connectivity ,resting-state networks ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2023
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42. Antibodies to coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared fibrinogen binding repeats
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Federico Bertoglio, Ya-Ping Ko, Sheila Thomas, Liliana Giordano, Francesca Romana Scommegna, Doris Meier, Saskia Polten, Marlies Becker, Srishtee Arora, Michael Hust, Magnus Höök, and Livia Visai
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Staphylococcus aureus ,monoclonal antibodies ,phage display ,fibrinogen-binding repeats ,coagulase ,Efb ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Staphylococcus aureus pathology is caused by a plethora of virulence factors able to combat multiple host defence mechanisms. Fibrinogen (Fg), a critical component in the host coagulation cascade, plays an important role in the pathogenesis of this bacterium, as it is the target of numerous staphylococcal virulence proteins. Amongst its secreted virulence factors, coagulase (Coa) and Extracellular fibrinogen-binding protein (Efb) share common Fg binding motives and have been described to form a Fg shield around staphylococcal cells, thereby allowing efficient bacterial spreading, phagocytosis escape and evasion of host immune system responses. Targeting these proteins with monoclonal antibodies thus represents a new therapeutic option against S. aureus. To this end, here we report the selection and characterization of fully human, sequence-defined, monoclonal antibodies selected against the C-terminal of coagulase. Given the functional homology between Coa and Efb, we also investigated if the generated antibodies bound the two virulence factors. Thirteen unique antibodies were isolated from naïve antibodies gene libraries by antibody phage display. As anticipated, most of the selected antibodies showed cross-recognition of these two proteins and among them, four were able to block the interaction between Coa/Efb and Fg. Furthermore, our monoclonal antibodies could interact with the two main Fg binding repeats present at the C-terminal of Coa and distinguish them, suggesting the presence of two functionally different Fg-binding epitopes.
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- 2023
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43. Giant lung bulla as a late-onset complication of mild SARS-CoV-2 pneumonia
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Matteo Petroncini, Leonardo Valentini, Piergiorgio Solli, and Pietro Bertoglio
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Emphysema ,bullae ,minimally invasive surgery ,COVID-19 ,Medicine - Abstract
A 49-year-old Caucasian man was admitted to the Emergency Department for shortness of breath and cough. CT imaging showed bilateral a mild COVID-19 related pneumonia. He was hospitalized in the low-intensity COVID-19 unit where he received O2 therapy and oral corticosteroids (CS). Three weeks after discharge a high-resolution computed tomography (HRCT) find a giant bulla of the inferior lobe. The bulla was resected by video-assisted thoracoscopic surgery (VATS) and the patient recovered completely. In our patient, it is reasonable to suspect that the development of the bulla is a result of SARS-CoV-2 infection, since no bulla was observed in the first HRCT two months before. SARS-CoV-2 related pneumonia may be responsible for lung remodeling due to diffuse alveolar damage and later interstitial myofibroblastic proliferation. Corticosteroids might have played a role in increasing SARS-CoV-2 dystrophic action. COVID-19 leads to pulmonary damages, which are still partially unknown and might result in development of bullae. In fit patient surgical treatment can be carried out safely.
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- 2023
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44. A comparative study of Fourier transform and CycleGAN as domain adaptation techniques for weed segmentation
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Riccardo Bertoglio, Alessio Mazzucchelli, Nico Catalano, and Matteo Matteucci
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Weed identification ,Semantic segmentation ,Domain adaptation ,Fourier transform ,Generative adversarial networks ,Agriculture (General) ,S1-972 ,Agricultural industries ,HD9000-9495 - Abstract
Automatic weed identification is becoming increasingly important in the Precision Agriculture field as a fundamental capability for targeted spraying or mechanical weed destruction. Targeted weed elimination reduces herbicides' use and thus lowers the environmental impact of treatments. Convolutional Neural Networks are one of the most successful techniques to automatically detect weeds on RGB images. Such models require a high amount of labeled data to obtain satisfying detection performance. The agricultural context presents a high degree of variability, and it is thus unfeasible to expect a representative dataset for each specific condition that can appear in the fields. Domain Adaptation techniques are exploited to maintain high detection performance in different field conditions, lowering the need for labeled data. This study presents a comparison of the two main style transfer techniques for performing domain adaptation, that is, the Fourier Transform and the CycleGAN architecture. We used these techniques to reduce the domain gap in two use cases: one with images collected by different robots with different cameras and another with images collected by the same platform in different years. We show how, in the first case, the CycleGAN architecture attains satisfying performance and beats the simpler Fourier Transform. Instead, in the second case, all the tested DA techniques struggle to reach baseline performance. We also show how introducing a loss based on phase discrepancy in the CycleGAN architecture stabilizes the training and improves the performance. Moreover, we release a new dataset of labeled agricultural images and the code of our experiments for the reproducibility of the results and comparison with future works.
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- 2023
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45. Automatic Mapping of Atrial Fiber Orientations for Patient-Specific Modeling of Cardiac Electromechanics using Image-Registration
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Hoermann, Julia M., Pfaller, Martin R., Avena, Linda, Bertoglio, Cristóbal, and Wall, Wolfgang A.
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Physics - Medical Physics ,Computer Science - Computational Engineering, Finance, and Science - Abstract
Knowledge of appropriate local fiber architecture is necessary to simulate patient-specific electromechanics in the human heart. However, it is not yet possible to reliably measure in-vivo fiber directions, especially in human atria. Thus, we present a method which defines the fiber architecture in arbitrarily shaped atria using image registration and reorientation methods based on atlas atria with fibers predefined from detailed histological observations. Thereby, it is possible to generate detailed fiber families in every new patient-specific geometry in an automated, time-efficient process. We demonstrate the good performance of the image registration and fiber definition on ten differently shaped human atria. Additionally, we show that characteristics of the electrophysiological activation pattern which appear in the atlas atria also appear in the patients' atria. We arrive at analogous conclusions for coupled electro-mechano-hemodynamical computations.
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- 2018
46. Magnetic moment impact on spin-dependent Seebeck coefficient of ferromagnetic thin films
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Alain Portavoce, Elie Assaf, Maxime Bertoglio, Dario Narducci, and Sylvain Bertaina
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Medicine ,Science - Abstract
Abstract Magnetic materials may be engineered to produce thermoelectric materials using spin-related effects. However, clear understanding of localized magnetic moments (µ I ), free carriers, and Seebeck coefficient (S) interrelations is mandatory for efficient material design. In this work, we investigate µ I influence on the spin-dependent S of model ferromagnetic thin films, allowing µ I thermal fluctuations, ordering, and density variation influence to be independently investigated. µ I influence on free carrier polarization is found to be of highest importance on S: efficient coupling of free carrier spin and localized magnetic moment promotes the increase of S, while spin-dependent relaxation time difference between the two spin-dependent conduction channels leads to S decrease. Our observations support new routes for thermoelectric material design based on spin-related effects in ferromagnetic materials.
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- 2023
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47. The new educational project Televascular Games during the Coronavirus Disease 2019 pandemic
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Emiliano Chisci, MD, Gianbattista Parlani, MD, Emanuele Gatta, MD, Giacomo Isernia, MD, Gianmarco de Donato, MD, Michele Antonello, MD, Gioele Simonte, MD, Tilo Kölbel, MD, Luca Bertoglio, MD, Kak Khee Yeung, MD, Konstantinos Donas, MD, Stefano Fazzini, MD, Nuno Dias, MD, and Stefano Michelagnoli, MD
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Telemedicine ,Telehealth ,Teleconsultation ,Education ,Training ,Thoraco-abdominal aortic disease ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: To report methodology and first-year results of a new educational project called Televascular Games,” which took place during coronavirus disease 2019 pandemic. Methods: Complex aneurysmal aortic disease was discussed during a 2-hour competition webinar, according to three modalities. (1) Planning case competition (PCC): Two to four preoperative computed tomography angiography (CTA) scans of an already performed selected case were submitted for the competition. CTA scans were uploaded anonymously, without any reference to the center or the surgeon who performed the case. The competitor had to prepare a presentation of how he or she would have diagnosed, sized, planned, treated, and followed up the case, of the medical therapy and of the bail-out maneuvers. (2) Challenging case competition (CCC): The competitor elaborates a presentation of an already treated case concerning an aortic topic and discusses sizing, planning, treatment, possible bail-out maneuvers and obtained results. For the CCC and PCC, the competitors with the best score were preselected to present and discuss their plan during the webinars. (3) Quiz competition: Two to six CTA scans of already performed selected aortic cases were submitted for the competition. A quiz with multiple choice questions was answered by the competitors. The top four competitors were selected for the webinars and then they discussed the cases during the webinar. Finally, at the end of the case discussion, the effective case resolution and follow-up were shown. A final winner was voted via televoting, based on six preestablished criteria. The project was endorsed by different national and international societies. Results: Between October 2020 and December 2021, there were 12 Italian and 1 international webinars with 1695 participants overall (mean, 130; range, 86-177). Competitors were 54 years of age (mean, 27 years; range, 22-38 years). Two editions were CCCs, two quiz competitions, and nine PCCs. The reliability of the interobserver sizing of competitors was κ = 0.43 and κ = 0.62 for the proximal and distal sealing measurements respectively and very good (κ = 0.88-0.95) in the evaluation of orientation of the vessels, presence of angulations, calcifications, and thrombus. The sizing discrepancy resulted in a significant variability of the planning (κ = 0.45). The project ranked 9.6 on a 10-point rating scale by all the participants and competitors. Conclusions: The formula of gaming and collegial discussion of aortic cases herein reported has proved valid and attractive during coronavirus disease 2019 pandemic period. The variability of the results on sizing and planning suggested to confer with a second opinion, especially for less experienced surgeons.
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- 2022
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48. Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis
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Bertoglio, Pietro, Aprile, Vittorio, Ventura, Luigi, Cattoni, Maria, Nachira, Dania, Lococo, Filippo, Perez, Maria Rodriguez, Guerrera, Francesco, Minervini, Fabrizio, Querzoli, Giulia, Bocchialini, Giovanni, Bacchin, Diana, Franzi, Francesca, Rindi, Guido, Bellafiore, Salvatore, Femia, Federico, Bogina, Giuseppe Salvatore, Solli, Piergiorgio, Kestenholz, Peter, Ruffini, Enrico, Paci, Massimiliano, Margaritora, Stefano, Imperatori, Andrea Selenito, Lucchi, Marco, Gnetti, Letizia, and Terzi, Alberto Claudio
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- 2022
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49. Mid-term oncological outcomes after complete versus conventional mesocolic excision for right-sided colon cancer: a propensity score matching analysis
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Giani, Alessandro, Bertoglio, Camillo Leonardo, Mazzola, Michele, Giusti, Irene, Achilli, Pietro, Carnevali, Pietro, Origi, Matteo, Magistro, Carmelo, and Ferrari, Giovanni
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- 2022
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50. Unsolved Issues in Thymic Epithelial Tumour Stage Classification: The Role of Tumour Dimension
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Carolina Sassorossi, Pietro Bertoglio, Filippo Lococo, Gloria Santoro, Elisa Meacci, Dania Nachira, Maria Teresa Congedo, Jury Brandolini, Matteo Petroncini, Adriana Nocera, Diepriye Charles-Davies, Piergiorgio Solli, Stefano Margaritora, and Marco Chiappetta
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thymic epithelial tumour ,staging system ,surgery ,oncology ,TNM ,Medicine (General) ,R5-920 - Abstract
According to the different classifications now in use, thymic tumours are staged by the extent of local invasiveness, and tumour size is not included as a major determinant for the T category. The aim of this double-site retrospective study is to analyse the correlation between tumour dimension and overall survival (OS) in patients who underwent surgical treatment. From January 2000 to December 2020, patients with thymic epithelial tumours who underwent surgical resection were included in this study. Data from a total of 332 patients were analysed. Five- and ten-year overall survival (5–10 YOS) was 89.26% and 87.08%, respectively, while five- and ten-year disease-free survival (DFS) was 88.12% and 84.2%, respectively. Univariate analysis showed a significant correlation between male sex (p-value 0.02), older age (p-value < 0.01), absence of myasthenia gravis (p-value < 0.01), increase in pTNM (pathological Tumor Node Metastasis) (p-value 0.03) and increase in the number of infiltrated organs (p-value 0.02) with an increase in tumour dimension. Tumour dimension alone was not effective in the prediction of DFS and OS, both when considered as a continuous variable and when considered with a cut-off of 3 and 5 cm. However, with multivariate analysis, it was effective in predicting OS in the aforementioned conditions (p-value < 0.01). Moreover, multivariate analysis was also used in the thymoma and Masaoka I subgroups. In our experience, the role of tumour dimension as a descriptor of the T parameter of the TNM (Tumor Node Metastasis) staging system seemed to be useful in improving this system.
- Published
- 2023
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