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4. Pegylated interferon α plus ribavirin for the treatment of chronic hepatitis C: A multicentre independent study supported by the Italian Drug Agency

Author

Mascolo, M.C., Cursaro, C., Scuteri, A., Ranieri, J., Monti, M., Bellentani, S., Gasbarrini, A., Pompili, M., Puoti, C., Bellis, L., Regazzetti, A., Maffezzini, E., Pietrangelo, A., Abbati, G., Raimondo, G., Scribano, L., Martines, D., Baroni, G. Svegliati, Faraci, G., Schianchi, S., Fornaciari, G., Fabris, P., Madonia, S., Civitavecchia, G., Pirisi, M., Smirne, C., Borghi, A., Sardini, C., Andreoletti, M., Morisco, F., Caporaso, N., Fargion, S., Fatta, E., Masutti, F., Bonaventura, M.E., Autolitano, A., Russello, M., Bellia, A., Toniutto, P., Bitetto, D., Mecenate, F., Pasulo, L., Lucà, M.G., Picardi, A., Vespasiani, U., Grattagliano, I., Palasciano, G., Romagno, D., Crespi, C., Gianstefani, A., Gobbo, G., Monti, V., Giannelli, G., Napoli, N., Nosotti, Raspanti, A., Cuccorese, Colombo, A.E., Floridia, Plattella, M.S., Cassano, P., Gentile, I., Blanc, P.L., Messina, V., Bonfante, S., Bellissima, P., Toti, M., Vecchiet, J., Falasca, K., Portelli, V., De Stefano, G., Pietromatera, G., Viganò, P., Re, T., Andreoni, M., Raineri, G., Massari, M., Grossi, P.A., Caputo, S., Cassola, G., Feasi, M., Foti, G., Kunkar, A., Corti, G., Baragli, F., Caterini, L., Migliorini, D., Chiodera, A., Calleri, G., Spezia, C., Baiguera, C., Puoti, M., Brancaccio, G., Gaeta, G.B., Vento, S., Di Biagio, A., Nicolini, L., Liberti, A., Iannece, M.D., Contini, C., Tacconi, D., Caremani, M., Almi, P., Chimenti, M., Cosco, Messeri, D., Esperti, F.C., Paffetti, A., Mastropietro, C., Moretti, A., Spagnolo, A.L., Lomonaco, L., Calì, A., Mandelli, G., Spinzi, G.C., Framarin, L., Berrutti, M., Boccia, S., Simone, L., Pazzi, P., Fornari, F., Comparato, G., Casetti, T., Foschi, F.G., Bertin, T., Salvagnini, M., Samori, A., Ferretti, E., Casiraghi, M.A., Marin, R., Ciancio, A., Campo, N., Testa, R., Rocco, A., Federico, A., Loguercio, C., Rizzo, S., Giannini, E.G., Corbo, M., Riegler, G., Esposito, P., Ricci, G.L., Rosina, Floriano, Tosti, Maria Elena, Borghesio, Elisabetta, Masocco, Maria, Mele, Alfonso, Coppola, Carmine, Milella, Michele, Borgia, Guglielmo, Andreone, Pietro, Koch, Maurizio, Zignego, Anna Linda, Romano, Mario, Carrara, Maurizio, Almasio, Piero Luigi, Azzola, Emilio, Nardone, Gerardo, Benedetti, Antonio, Carosi, Giampiero, Mazzotta, Francesco, Sagnelli, Evangelista, and Rizzetto, Mario

Published
2014
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5. Generation and molecular characterization of paired human penile epithelial primary cell lines derived from patients with penile cancer

Author

Broad, S., primary, Hachim, M., additional, Bertin, T., additional, Hamoudi, R., additional, Xiel, B., additional, Khan, S., additional, Penderecka, K., additional, Henrique, R., additional, Machulla, N., additional, Arya, M., additional, Thrasivolou, C., additional, Ahmed, A., additional, and Muneer, A., additional

Published
2022
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7. The spectrum of ammonia near 0.793 μm

Author

Zobov, N.F., primary, Bertin, T., additional, Vander Auwera, J., additional, Civiš, S., additional, Knížek, A., additional, Ferus, M., additional, Ovsyannikov, Roman I., additional, Makhnev, Vladimir Yu., additional, Tennyson, Jonathan, additional, and Polyansky, Oleg L., additional

Published
2021
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10. Impact of HBV infection in HCV/HBV coinfected patients treated with DAAs IN Northern Italy

Author

Fabris, P., primary, Noventa, F., additional, Pasulo, L., additional, Farina, F., additional, Carollo, G., additional, Carlotto, A., additional, Rovere, P., additional, Cavinato, S., additional, Romano, A., additional, Vario, A., additional, Fraceschet, I., additional, Panese, S., additional, Bertin, T., additional, Zappalà, F., additional, Alberti, A., additional, Lobello, S., additional, Aghemo, A., additional, Bruno, R., additional, Puoti, M., additional, Rizzardini, G., additional, Spinelli, O., additional, Pigozzi, MG., additional, Spinetti, A., additional, Menzaghi, B., additional, Pan, A., additional, Bella, D., additional, Re, T., additional, Borghi, M., additional, Lombardi, A., additional, Viganò, M., additional, Salpietro, S., additional, Lleo, A., additional, and Fagiuoli, S., additional

Published
2020
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13. Hepatitis E in Italy: 5 years of national epidemiological, virological and environmental surveillance, 2012 to 2016

Author

Alfonsi, V., Romano, L., Ciccaglione, A. R., La Rosa, G., Bruni, R., Zanetti, A., Libera, S. D., Iaconelli, M., Bagnarelli, P., Capobianchi, M. R., Garbuglia, A. R., Riccardo, F., Tosti, M. E., Ferrigno, L., Crateri, S., Galli, C., Tagliacarne, C., Giordani, M. T., Morelli, E., Vit, A., Bertin, T., Marinello, S., De Checchi, G., Zotti, C., Amprino, V., Rossati, A., Di Vito, A., Guidoni, C., Fiacchini, D., Marinelli, K., Loffredo, M., De Angelis, G., Citarella, A., and Megnia, A. S.

Subjects
0301 basic medicine, Swine, Sewage, Wastewater, medicine.disease_cause, Surveillance and Outbreak Report, 0302 clinical medicine, Hepatitis E virus, Epidemiology, Genotype, 80 and over, risk factors, 030212 general & internal medicine, Viral, Child, Phylogeny, Aged, 80 and over, Travel, Transmission (medicine), Middle Aged, Hepatitis E, 6. Clean water, 3. Good health, One Health, Italy, surveillance, RNA, Viral, epidemiology, Travel-Related Illness, Environmental Monitoring, Adult, medicine.medical_specialty, Adolescent, viral infections, Food Contamination, 03 medical and health sciences, Young Adult, Virology, Environmental health, medicine, Animals, Humans, Waste Water, Risk factor, Aged, business.industry, Public Health, Environmental and Occupational Health, medicine.disease, 030104 developmental biology, RNA, business
Abstract

Increasing numbers of hepatitis E cases are being reported in several European countries, including Italy, but the burden of hepatitis E virus (HEV) infection is largely unknown in the latter. To gain a better understanding of HEV epidemiology at national level in Italy, we piloted a strengthened and integrated human (epidemiological and virological) and environmental HEV surveillance system between 2012 and 2016. Over the 5-year period, 169 confirmed hepatitis E cases were identified, with a national annual incidence of 0.72 cases per 1,000,000. Of 65 HEV-RNA positive samples of sufficient quality for molecular analysis, 66% were genotype HEV3, 32% HEV1 and 1% HEV4. The most frequent risk factor reported by all HEV3 infected cases, was the consumption of undercooked pork and sausage. For the environmental surveillance, 679 urban sewage samples were collected from 53 wastewater treatment plants and HEV-RNA was detected in 38/679 of the samples. Among these, 25 (66%) were genotype HEV3 and the remaining were HEV1. We demonstrate that autochthonous transmission and environmental circulation of genotype HEV3 is adding to travel-related HEV transmission in Italy. We recommend the ‘One Health’ approach to integrated surveillance, and to include HEV-related messages within health information campaigns focussing on food security.

Published
2018

14. Confirmation of anti-HCV EIA reactivities by RIBA and neutralization assay among blood donors and patients with chronic liver disease and hepatocellular carcinoma

Author

Tanzi, E., primary, Galli, C., additional, Delaito, M., additional, Bertin, T., additional, Pizzocolo, G., additional, Rodella, A., additional, Buscarini, L., additional, Sbolli, G., additional, Rossi, U., additional, Romano, L., additional, Chiaramonte, M., additional, and Zanetti, Alessandro R., additional

Published
1992
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19. Pegylated interferon α plus ribavirin for the treatment of chronic hepatitis C: A multicentre independent study supported by the Italian Drug Agency

Author

Rosina, Floriano, Tosti, Maria Elena, Borghesio, Elisabetta, Masocco, Maria, Mele, Alfonso, Coppola, Carmine, Milella, Michele, Borgia, Guglielmo, Andreone, Pietro, Koch, Maurizio, Zignego, Anna Linda, Romano, Mario, Carrara, Maurizio, Almasio, Piero Luigi, Azzola, Emilio, Nardone, Gerardo, Benedetti, Antonio, Carosi, Giampiero, Mazzotta, Francesco, Sagnelli, Evangelista, Rizzetto, Mario, Mascolo, M. C., Cursaro, C., Scuteri, A., Crespi, C., Gianstefani, A., Ranieri, J., Monti, M., Corti, G., Blanc, P. L., Baragli, F., Bellentani, S., Gasbarrini, A., Pompili, M., Mecenate, F., Picardi, A., Vespasiani, U., Nosotti, Null, Null, A. Picardi, Ricci, G. L., Paffetti, A., Mastropietro, C., Moretti, A., Spagnolo, A. L., Puoti, C., Bellis, L., Regazzetti, A., Maffezzini, E., Pietrangelo, A., Abbati, G., Borghi, A., Sardini, C., Raimondo, G., Scribano, L., Martines, D., Svegliati Baroni, G., Faraci, G., Schi anchi, S., Fornaciari, G., Massari, M., Fabris, P., Bertin, T., Salvagnini, M., Madonia, S., Calì, A., Civitavecchia, G., Pirisi, M., Smirne, C., Andreoletti, M., Morisco, F., Caporaso, N., Gentile, I., Brancaccio, G., Gaeta, G. B., Liberti, A., Iannece, M. D., Rocco, A., Federico, A., Loguercio, C., Riegler, G., Esposito, P., Fargion, S., Fatta, E., Masutti, F., Bonaventura, M. E., Autolitano, A., Russello, M., Bellia, A., Toniutto, P., Bitetto, D., Pasulo, L., Lucà, M. G., Grattagliano, I., Palasciano, G., Romagno, D., Giannelli, G., Napoli, N., Plattella, M. S., Cassano, P., Gobbo, G., Monti, V., Raspanti, A., Cuccorese, Null, Colombo, A. E., Mandelli, G., Spinzi, G. C., Floridia, Null, Messina, V., Bonfante, S., Bellissima, P., Toti, M., Vecchiet, J., Falasca, K., Portelli, V., Stefano, G. De, Pietromatera, G., Viganò, P., Re, T., Andreoni, M., Null, G. Raineri, Grossi, P. A., Caputo, S., Cassola, G., Feasi, M., Biagio, A. Di, Nicolini, LAURA AMBRA, Giannini, EDOARDO GIOVANNI, Corbo, M., Foti, G., Kunkar, A., Caterini, L., Migliorini, D., Chiodera, A., Calleri, G., Spezia, C., Framarin, L., Null, M. Berrutti, Ciancio, A., Baiguera, C., Puoti, M., Vento, S., Contini, C., Boccia, S., Casiraghi, M. A., Simone, L., Tacconi, D., Caremani, M., Almi, P., Chimenti, M., Cosco, Null, Messeri, D., Esperti, F. C., Lomonaco, L., Pazzi, P., Fornari, F., Comparato, G., Casetti, T., Foschi, F. G., Samori, A., Ferretti, E., Marin, R., Campo, N., Testa, R., Rizzo, S., Rosina, F, Tosti, ME, Borghesio, E, Masocco, M, Mele, A, Coppola, C, Milella, M, Borgia, G, Andreone, P, Koch, M, Zignego, AL, Romano, M, Carrara, M, Almasio, PL, Azzola, E, Nardone, G, Benedetti, A, Carosi, G, Mazzotta, F, Sagnelli, E, Rizzetto, M, Rosina, F., Tosti, M. E., Borghesio, E., Masocco, M., Mele, A., Coppola, C., Milella, M., Borgia, Guglielmo, Andreone, P., Koch, M., Zignego, A. L., Romano, M., Carrara, M., Almasio, P. L., Azzola, E., Nardone, GERARDO ANTONIO PIO, Benedetti, A., Carosi, G., Mazzotta, F., Sagnelli, E., Rizzetto, M., Aifa, Aisf, Simit, Aigo, Sige, Gentile, Ivan, Morisco, Filomena, Et, Al, Floriano Rosina, Maria Elena Tosti, Elisabetta Borghesio, Maria Masocco, Alfonso Mele, Carmine Coppola, Michele Milella, Guglielmo Borgia, Pietro Andreone, Maurizio Koch, Anna Linda Zignego, Mario Romano, Maurizio Carrara, Piero Luigi Almasio, Emilio Azzola, Gerardo Nardone, Antonio Benedetti, Giampiero Carosi, Francesco Mazzotta, Evangelista Sagnelli, and Mario Rizzetto

Subjects
Registrie, Male, Cirrhosis, medicine.disease_cause, Polyethylene Glycol, Gastroenterology, Polyethylene Glycols, chemistry.chemical_compound, Hepatitis Viruses, Hepatitis Viruse, Prospective Studies, Viral, Registries, Chronic, Prospective cohort study, Drug Carrier, Drug Carriers, Settore MED/12 - Gastroenterologia, Medicine (all), Recombinant Protein, Middle Aged, Hepatitis C, Recombinant Proteins, Treatment Outcome, Italy, Combination, RNA, Viral, Population study, Drug Therapy, Combination, Female, Human, medicine.medical_specialty, Genotype, Hepatitis C virus, Alpha interferon, Ribavirin, Sustained virological response (SVR), Treatment, Antiviral Agents, Follow-Up Studie, Hepatology, Drug Therapy, Internal medicine, medicine, Humans, Antiviral Agent, business.industry, Interferon-alpha, HCV therapy, Hepatitis C, Chronic, medicine.disease, Clinical trial, Prospective Studie, chemistry, Immunology, RNA, Follow-Up Studies, business
Abstract

a b s t r a c t Background: Data on the efficacy of Peg-interferon/ribavirin therapy for chronic hepatitis C are mostly derived from treatment of selected patients enrolled in clinical trials. This study aimed to assess the effectiveness of Peg-interferon/ribavirin therapy in “real world” chronic hepatitis C patients in Italy. Methods: Independent observational multicentre study including consecutive patients receiving Peginterferon/ribavirin in the 18 months before (retrospective phase) and after (prospective phase) the start of the study. Results: 4176 patients were eligible. The final study population consisted of 2051 patients in the retrospective and 2073 in the prospective phase. Sustained virological response was achieved by 1036 patients (50.5%) during the retrospective phase: 325 were genotypes 1/4 (34.1%) and 684 were genotypes 2/3 (67.2%) and by 800 patients (38.6%) during the prospective phase: 300 were genotypes 1/4 (28.4%) and 473 were genotypes 2/3 (51.5%). During multivariate analysis genotypes 2/3 were significantly associated with higher sustained virological response rates; cirrhosis and -glutamil-transpeptidase >2 times the normal limit were associated with poorer response. Conclusions: The response to Peg-interferon/ribavirin therapy in “real world” clinical practice is distinctly lower than in registration trials. The difference in response rates was more pronounced among easy-totreat than among difficult-to-treat hepatitis C virus genotypes.

Published
2014

20. Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model

Author

McCORMACK, W. M., BERTIN, T. K., PALMER, D. J., NG, P., SEILER, M. P., UBHAYAKAR, K., NICHOLS, T. C., and LEE, B.

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, hemic and lymphatic diseases
Abstract

Adenoviral vector-mediated gene therapy might have potential for long-term correction of the monogenic disease hemophilia A.

Published
2006
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21. Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis

Author

Premkumar, M. H., primary, Sule, G., additional, Nagamani, S. C., additional, Chakkalakal, S., additional, Nordin, A., additional, Jain, M., additional, Ruan, M. Z., additional, Bertin, T., additional, Dawson, B., additional, Zhang, J., additional, Schady, D., additional, Bryan, N. S., additional, Campeau, P. M., additional, Erez, A., additional, and Lee, B., additional

Published
2014
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22. Final report of a consensus interferon (CIFN) plus ribavirin (RBV) study for chronic hepatitis C (CHC)

Author

Zagni, Irene, Minola, E., Felder, M., Rovere, P., Carlotto, A., Suppressa, S., Miracolo, A. M., Paternoster, C., Rizzo, C., Rossini, A., Benedetti, P., Pignalosa, P., Costa, P., Ferrara, C., Bertin, T., Pantalena, M., Lomonaco, L., Scattolini, C., Mazzella, G., Boccia, S., Milani, S., Marin, R., Ribero, M. L., Tagger, A., and Fattovich, Giovanna

Subjects
therapy, ribavirin, chronic hepatitis C, interferon
Published
2003

23. Efficacy of consensus interferon (CIFN) plus ribavirin (RBV) as initial treatment for chronic hepatitis C patients: an italian multicentre study

Author

Zagni, Irene, Minola, E., Felder, M., Rovere, P., Carlotto, A., Suppressa, S., Miracolo, A. M., Paternoster, C., Rizzo, C., Rossini, A., Benedetti, P., Milani, S., Ferrara, C., Costa, P., Bertin, T., Pantalena, M., Fabris, F., Lomonaco, L., Mazzella, G., Boccia, S., Marin, R., Ribero, M. L., Tagger, A., and Fattovich, Giovanna

Subjects
therapy, ribavirin, chronic hepatitis C, consensus interferon
Published
2002

26. Antibody pattern of HCV infection and hepatocellular carcinoma in Itakly: A case control study

Author

Rapicetta, M, Stroffolini, T., Chiaramonte, M., Tiribelli, Claudio, Villa, E., Simonetti, R. G., Stazi, M. A., Chionne, P., Bertin, T., Croce', Saveria, Magliocco, P. TRANDE AND A., K. NISHIOKA, H. SUZUKI, S. MISHIRO AND T. ODA, Rapicetta, M, T., Stroffolini, M., Chiaramonte, Tiribelli, Claudio, E., Villa, R. G., Simonetti, M. A., Stazi, P., Chionne, T., Bertin, Croce', Saveria, and P. TRANDE AND A., Magliocco

Published
1994

31. Integrin upregulation on sputum neutrophils in smokers with chronic airway obstruction

Author

UCL, Maestrelli, P, Calcagni, PG, Saetta, M, Bertin, T, Mapp, CE, Sanna, A., Veriter, C., Fabbri, LM, Stanescu, Dan, UCL, Maestrelli, P, Calcagni, PG, Saetta, M, Bertin, T, Mapp, CE, Sanna, A., Veriter, C., Fabbri, LM, and Stanescu, Dan

Abstract

To determine the relationship between the expression of leukocyte-specific integrins in the airways and the airway obstruction in smokers, we analyzed hypertonic saline-induced sputum in 33 male subjects, age 64.7 +/- 0.5 yr (mean +/- SEM), with a smoking history of 12 to 94 pack-years, at the end of a 15-yr follow-up study. Average FEV(1)/VC ratio was 69 +/- 1% at the beginning of the study and 66 +/- 2% at the end of the follow-up period, and annual decline of FEV(1) was 20 +/- 3 ml/yr. Fourteen individuals exhibited airway obstruction as assessed by a FEV(1)/VC ratio lower than 63.3%. Differential leukocyte count was performed on cytospin preparations and the expression of integrin alpha (CD11a, CD11b, CD11c) and beta (CD18) chains was assessed on granulocytes and mononuclear cells by immunocytology. The numbers of neutrophils expressing CD11b and CD18, but not CD11c or CD11a, were increased in the subjects with airway obstruction compared with those without airway obstruction. CD11b- and CD18-positive neutrophils were negatively correlated with FEV(1)/VC ratio (p < 0.01). No significant correlations were found between CD11a-, CD11b-, CD11c-, CD18-positive mononuclear cells and lung function measurements. In conclusion, our results suggest that leukocyte-specific integrin CD11b/CD18 expressed on sputum polymorphonuclear leukocytes represents a marker for the smokers who develop chronic airway obstruction.

Published
1996

41. Prevention of acute NSAID-related gastroduodenal damage: a meta-analysis of controlled clinical trials.

Author

Leandro, Gioacchino, Pilotto, Alberto, Franceschi, Marilisa, Bertin, Tosca, Lichino, Emanuela, Di Mario, Francesco, Leandro, G, Pilotto, A, Franceschi, M, Bertin, T, Lichino, E, and Di Mario, F

Subjects
DRUG therapy for arthritis, GASTROINTESTINAL agents, MISOPROSTOL, H2 receptor antagonists, COMPARATIVE studies, DUODENUM, RESEARCH methodology, MEDICAL cooperation, META-analysis, NONSTEROIDAL anti-inflammatory agents, RESEARCH, STOMACH, SYSTEMATIC reviews, PROTON pump inhibitors, EVALUATION research, THERAPEUTICS
Abstract

No consensus exists as to whether cotherapy is effective in the short-term prevention of severe NSAID-related gastroduodenal damage. The aim of this study was to provide a quantitative systematic review of the efficacy of gastroprotective drugs, such as misoprostol, H2-blockers, and proton pump inhibitors (PPI) in preventing the severe acute NSAID-related gastroduodenal damage. Placebo-controlled randomized clinical trials on the use of misoprostol, H2-blockers, and PPIs as preventative agents published between January 1986 and May 1999 were identified through Medline and reference lists from clinical reviews. Studies on patients or healthy subjects were considered to be eligible for data pooling if they were performed in acute NSAID users (not longer than 30 days) and with at least one endoscopic evaluation during therapy that reported results specifically for gastric and duodenal damage. Risk difference (RD), heterogeneity χ2 test, publication bias assessment and number needed to treat (NnT) were calculated for each meta-analysis by a customized program. Twenty-one trials met the inclusion criteria evaluating a total of 636 healthy subjects and 1904 patients with arthritis randomized to active drug or placebo. The baseline risk of NSAID-related gastric (68% vs 16.6%, P < 0.001) and duodenal (22% vs 8.5%, P < 0.001) damage was higher in healthy subjects compared to patients with arthritis. Meta-analysis demonstrated a significant heterogeneity between trials performed in the two populations (P < 0.0001). In healthy subjects the active drug treatment induced a significant prevention of severe gastric (misoprostol RD = 69%, 95% CI = 60.3–77.7, H2-blocker RD = 38.3%, 95% CI = 17.8–58.9 and PPI RD = 43%, 95% CI = 28.2–57.7) and duodenal damage (misoprostol RD = 22.3%, 95% CI = 13.6–31, H2-blocker RD = 13.2%, 95% CI = 5.2–21.3 and PPI RD = 17.7%, 95% CI = 3.5–31.8). NnT values were, respectively, 1, 3, and 2 for gastric and 4, 8, and 6 for duodenal damage. In patients with arthritis lower RD and higher NnT values were found compared to healthy subjects. In conclusions, cotreatment with gastroprotective drugs for short-term prevention of severe gastroduodenal NSAID-related damage was more effective in healthy subjects than in patients with arthritis; misoprostol and PPIs were more effective than H2-blockers in the prevention of both gastric and duodenal severe damage; more studies need to evaluate the role of short-term prevention in patients with arthritis who require acute NSAID treatment. [ABSTRACT FROM AUTHOR]

Published
2001
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45. Le epatiti croniche: inquadramento nosografico

Author

Chiaramonte, M, Martines, D, Floreani, A, Fabris, P, Fagiuoli, S, Bertin, T, Naccarato R, Chiaramonte, M, Martines, D, Floreani, A, Fabris, P, Fagiuoli, S, and Bertin, T

Subjects
epatiti croniche, inquadramento nosografico
Published
1989

47. Gene diversity and estimation of genetic admixture among Mexican-Americans of Starr County, Texas

Author

Cerda-Flores, R. M., Kshatriya, G. K., Bertin, T. K., Hewett-Emmett, D., Hanis, C. L., and Chakraborty, R.

Abstract

The Mexican-Americans of Starr County, Texas, classified by sex and birth-place, were studied to determine the extent of genetic variation and contributions from ancestral populations such as Spanish, Amerindian and West African. Using 21 genetic marker systems, genetic distance and diversity analyses indicate that subpopulations of Mexican-Americans in Starr County are similar, and that more than 99% of the total gene diversity (HT) can be attributed to individual variation within the population. Genetic admixture analysis shows the predominant influence comes from the Spanish, a lesser contribution from Amerindians and a slight one from the West Africans. The contribution of the ancestral population to various subpopulations of the Mexican-Americans of Starr County is similar. The Mexican-Americans of Starr County are similar to the Mexican population from northeastern Mexico. The history of admixture is apparently old enough to have brought the entire Mexican-American gene pool to Hardy-Weinberg equilibrium. There is no non-random association of alleles among the genetic marker systems considered in the present study, in spite of the fact that this population is of admixed origin. These results, in aggregate, suggest genetic homogeneity of the Mexican-Americans of Starr County, Texas, and point towards the utility of this population for genetic and epidemiological studies.

Published
1992
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48. A Rare Occurrence of Hairy Cell Leukemia in a Congolese Child

Author

Ehungu, Jean Lambert K. Gini, Mufuta, Jean-Pierre N., Ngiyulu, René M., Ekulu, Pépé M., Kadima, Bertin T., and Aloni, Michel N.

Abstract

Hairy cell leukemia is a rare form of leukemia and has been rarely reported in African and pediatric population.

Published
2013

49. The Multinational Andean Genetic and Health Program. IX. Gene frequencies and rare variants of 20 serum proteins and erythrocyte enzymes in the Aymara of Chile

Author

Ferrell, R. E., Bertin, T., Sara Ann Barton, Rothhammer, F., and Schull, W. J.

Subjects
Male, Erythrocytes, Polymorphism, Genetic, Acclimatization, Altitude, Indians, South American, education, Genetic Variation, Blood Proteins, Enzymes, Gene Frequency, Spain, Ethnicity, Humans, Female, Chile, Selection, Genetic, Alleles, Research Article
Abstract

Electrophoretic variants at 22 genetic loci in the Aymara, mestizo, and Spanish populations of northern Chile are presented, and their possible role in adaptation to hypoxic environments are discussed. Some apparently unique variants were found.

Published
1980

50. Le epatiti croniche: inquadramento nosografico

Author

Naccarato R, Chiaramonte, M, Martines, D, Floreani, A, Fabris, P, Fagiuoli, S, Bertin, T, Naccarato R, Chiaramonte, M, Martines, D, Floreani, A, Fabris, P, Fagiuoli, S, and Bertin, T

Published
1989

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