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Throughout this study, we employed unsupervised machine learning clustering algorithms, namely K-Means [1] and hierarchical agglomerative clustering (HAC) [2], to explore human locomotion and wayfinding using a VR Magic Carpet (VMC) [3], a table test version known as the Corsi Block Tapping task (CBT) [4]. This variation was carried out in the context of a virtual reality experimental setup. The participants were required to memorize a sequence of target positions projected on the rug and walk to each target figuring in the displayed sequence. the participant’s trajectory was collected and analyzed from a kinematic perspective. An earlier study [5] identified three different categories, but the classification remained ambiguous, implying that they include both kinds of individuals (normal and patients with cognitive spatial impairments). On this basis, we utilized K-Means and HAC to distinguish the navigation behavior of patients from normal individuals, emphasizing the most important discrepancies and then delving deeper to gain more insights.

Abstract Functional inhibition is known to improve treatment outcomes in substance use disorder (SUD), potentially through craving management enabled by underlying cerebral integrity. Whereas treatment is challenged by a multitude of substances that patients often use, no study has yet unraveled if inhibition and related cerebral integrity could prevent relapse from multiples substances, that is, one’s primary drug of choice and secondary ones. Individuals with primary alcohol, cannabis, or tobacco use disorders completed intensive Ecological Momentary Assessment (EMA) coupled with resting-state functional MRI (rs-fMRI) to characterize the extent to which inhibition and cerebral substrates interact with craving and use of primary and any substances. Participants were 64 patients with SUD and 35 healthy controls who completed one week EMA using Smartphones to report 5 times daily their craving intensity and substance use and to complete Stroop inhibition testing twice daily. Subsamples of 40 patients with SUD and 34 control individuals underwent rs-fMRI. Mixed Model Analysis revealed that reported use of any substance by SUD individuals predicted later use of any and primary substance, whereas use of the primary substance only predicted higher use of that same substances. Craving and inhibition level independently predicted later use but did not significantly interact. Preserved inhibition performance additionally influenced use indirectly by mediating the link between subsequent uses and by being linked to rs-fMRI connectivity strength in fronto-frontal and cerebello-occipital connections. As hypothesized, preserved inhibition performance, reinforced by the integrity of inhibitory neurofunctional substrates, may partake in breaking an unhealthy substance use pattern for a primary substance but may not generalize to non-target substances or to craving management.

Abstract Background Although renal damage is increasingly reported among the most undernourished patients with Anorexia Nervosa (AN), it remains underestimated in current practice, and often associated with acute dehydration. The purpose of our study was to evaluate the frequency, the extent, and the risk factors of renal involvement among adolescents and adults hospitalized in specialized units for AN. Methods In this multi-center study, 197 consecutive participants were included, aged 13–65, from 11 inpatient eating disorder psychiatric units. Information on the course of AN, clinical characteristics, biological data, and medication were collected. Results At admission, mean BMI was 13.1 (± 1.6) kg/m2 for a mean age of 20.74 (± 6.5) years and the z-score was − 3.6 (± 1.33). Six participants (3.0%) had hyponatremia, four (2.0%) had hypokalemia, and nine (4.5%) had hypochloremia. The Blood Urea Nitrogen/Creatinine ratio was over 20 for 21 (10.6%) participants. The mean plasma creatinine was 65.22 (± 12.8) µmol/L, and the mean eGFR was 74.74 (± 18.9) ml/min. Thirty- five participants (17.8%) had an eGFR > 90 ml/min, 123 (62.4%) from 60 to 90 ml/min, 35 (17.8%) from 45 to 60 ml/min, and 4 (2%) under 45 ml/min. In multivariate analysis, only BMI on admission was a determinant of renal impairment. The lower the BMI the more severe was the renal impairment. Conclusion When eGFR is calculated, it highlights renal dysfunction found in severe AN requiring hospitalisation in specialized units. The severity of undernutrition is an independent associated factor. Kidney functionality tests using eGFR, in addition to creatinine alone, should be part of routine care for patients with AN to detect underlying renal dysfunction.

A Perrochon,1,2,5 G Kemoun,1,2 E Watelain,3,4 A Berthoz51ISIS, Research Institute on Handicap and Aging, Paris; 2Université de Poitiers, Laboratoire Mobilité, Vieillissement et Exercice (MOVE), EA 6314, 3Université de Valenciennes, LAMIH, UMR CNRS 8201, 4Université Sud Toulon Var, HandiBio, EA 4322, La Garde, 5LPPA, UMR CNRS 7152, Collège de France, Paris, FranceBackground: Several studies have reported the potential value of the dual-task concept during locomotion in clinical evaluation because cognitive decline is strongly associated with gait abnormalities. However, current dual-task tests appear to be insufficient for early diagnosis of cognitive impairment.Methods: Forty-nine subjects (young, old, with or without mild cognitive impairment) underwent cognitive evaluation (Mini-Mental State Examination, Frontal Assessment Battery, five-word test, Stroop, clock-drawing) and single-task locomotor evaluation on an electronic walkway. They were then dual-task-tested on the Walking Stroop carpet, which is an adaptation of the Stroop color–word task for locomotion. A cluster analysis, followed by an analysis of variance, was performed to assess gait parameters.Results: Cluster analysis of gait parameters on the Walking Stroop carpet revealed an interaction between cognitive and functional abilities because it made it possible to distinguish dysexecutive cognitive fragility or decline with a sensitivity of 89% and a specificity of 94%. Locomotor abilities differed according to the group and dual-task conditions. Healthy subjects performed less well on dual-tasking under reading conditions than when they were asked to distinguish colors, whereas dysexecutive subjects had worse motor performances when they were required to dual task.Conclusion: The Walking Stroop carpet is a dual-task test that enables early detection of cognitive fragility that has not been revealed by traditional neuropsychological tests or single-task walking analysis.Keywords: stroop, dual-task, walking, mild cognitive impairment

Background: According to the Cognitive–Interpersonal model of anorexia nervosa (AN), the combined influence of cognitive and socio-emotional difficulties would constitute vulnerability and maintaining factors. Poor cognitive flexibility is one of the endophenotypic candidates (i.e., a trait marker) of the disorder, but few studies have examined its association with illness symptom variations, notably weight status. The study aimed to evaluate the relationships between cognitive flexibility performances and nutritional status indices (BMI; body composition) at different times of the disorder. Methods: Cross-sectional and longitudinal associations between cognitive flexibility (TAP 2.1) and nutritional status indices, along with anxious and depressive (HAD) and eating disorder (EDE-Q) symptomatology were investigated using univariate and multivariate analyses in a cohort of AN inpatients evaluated at hospital admission (N = 167) and discharge (N = 94). Results: We found no or negligible associations between nutritional status and HAD or EDE-Q scores or cognitive flexibility performances, either cross-sectionally or longitudinally. Cognitive performances did not significantly differ between the AN subtypes. Conclusions: In agreement with the Cognitive–Interpersonal model of AN, cognitive flexibility is independent of nutritional status, as well as the AN subtype. It is also independent of the levels of anxious, depressive, or ED symptomatology. A new therapeutic approach targeting cognitive flexibility and intolerance to change could benefit severely emaciated people with AN, regardless of disease subtype and level of dysphoria.

Background: Patients treated for Substance Use Disorders exhibit highly fluctuating patterns of craving that could reveal novel prognostic markers of use. Accordingly, we 1) measured fluctuations within intensively repeated measures of craving and 2) linked fluctuations of craving to connectivity indices within resting-state (rs) brain regions to assess their relation to use among patients undergoing treatment for Alcohol, Tobacco and Cannabis Use Disorders Method: Participants —64 individuals with SUD for tobacco, alcohol, or cannabis and 35 healthy controls— completed a week of Ecological Momentary Assessment (EMA) during which they reported craving intensity and substance use five times daily. Before EMA, a subsample of 50 patients, and 34 healthy controls also completed resting-state (rs)-MRI acquisitions. Craving temporal dynamics within each day were characterized using Standard Deviation (SD), Auto-Correlation Factor (ACF), and Mean Successive Square Difference (MSSD). Absolute Difference (AD) in craving between assessments was a prospective prediction measure. Results: Within-day, higher MSSD predicted greater substance use while controlling for mean craving. Prospectively higher AD predicted later increased substance use independently of previous use or craving level. Moreover, MSSD was linked to strength in five functional neural connections, most involving frontotemporal systems. Cerebello-thalamic and thalamo-frontal connectivity were also linked to substance use and distinguished the SUD from the controls. Conclusion: To the best of our knowledge, this is the first study to indicate that instability in craving may be a trigger for use in several SUD types, beyond the known effect of craving intensity.

A major full-scale experiment called the Tunnelling and Limitation of Impacts on Piles (TULIP) project was conducted in 2020 on Line 16 of the Grand Paris Express project to analyze the tunnel boring machine–soil–pile interactions during tunnel excavation near deep structures. This paper presents the greenfield ground response observed when the tunnel boring machine (TBM) crossed the TULIP site: surface displacements, subsurface displacements, and pore water pressures are presented. The originality of the paper lies in the fact that details are provided not only on the site geological and geotechnical characteristics, but also on the TBM operation: a detailed analysis of the variations in pressure inside the cutting chamber of the earth-pressure balanced machine (EPBM) is proposed. This paper reports factual data without bias induced by a preconceived numerical model, but highlights open questions that challenge the advanced numerical models, that will be required to analyze completely the tunnel–soil–pile interactions. [ABSTRACT FROM AUTHOR]

Children's early emotional environment strongly influences their later behavioural development. Yet, besides maternal depression, limited knowledge exists about the effect of other emotions and the role of fathers. Using 290 triads (mother/father/child), we investigated how positive (SEEKING, CARING, PLAYFULNESS) and negative (FEAR, ANGER, SADNESS) dimensions of mothers' and fathers' affectivity relate to their offspring's externalizing and internalizing behaviours directly as well as indirectly via parenting practices. Parental variables were measured when children were 4 years old and children's behaviours were measured at 8 years of age. Latent Profile Analysis identified three parental affective profiles: "low negative emotions," "balanced," and "high emotional." Structural equation models showed that, for boys, mothers' "low negative emotions" and "high emotional profiles" predicted later internalizing behaviours (direct effect; [beta] = -0.21 and [beta] = 0.23), while fathers' "low negative emotions" profile predicted externalizing behaviours indirectly ([beta] = -0.10). For girls, mothers' profiles ("low negative emotions" and "high emotional") predicted both internalizing ([beta] = -0.04 and [beta] = 0.07) and externalizing ([beta] = -0.05 and [beta] = 0.09) behaviours indirectly, but no effects of fathers' profiles were found. Mothers' and fathers' affective profiles contributed to the behavioural development of their offspring in different ways, according to the type of behaviour (internalizing or externalizing) and the child's sex. These findings may help in tailoring existing parenting interventions on affective profiles, thus enhancing their efficacy.

Objective: Previous studies have highlighted the relevance of perfectionism, self‐esteem, and anxio‐depressive symptoms in anorexia nervosa (AN). However, the relationships between these factors and cardinal eating disorders (ED) symptoms remain unclear, particularly in AN subtypes. This study aimed to examine their interconnections using network analysis. Method: The sample included n = 338 inpatients with AN who completed the Eating Disorder Examination Questionnaire, Frost Multidimensional Perfectionism Scale, Rosenberg Self‐Esteem Scale, and Hospital Anxiety and Depression Scale. Using network analysis, we estimated three networks: full sample, AN‐restrictive (AN‐R) and AN‐binge/purging (AN‐BP) subtypes. We estimated central and bridge symptoms using expected influence and conducted an exploratory network comparison test to compare AN subtypes. Results: Overvaluation of Weight and Shape, Concern over Mistakes, and Personal Standards were consistently central in all networks. The most central bridge symptoms across all networks were Concern over Mistakes and Self‐Esteem. Concern over Mistakes bridged perfectionism and ED symptoms, while Self‐Esteem was highly connected to all symptom clusters. Anxiety was significantly more central in the AN‐R network compared to the AN‐BP network. Conclusions: The present study contributes to a growing body of network studies suggesting that nodes related to perfectionism are just as central as cardinal ED symptoms, indicating the relevance of perfectionism in ED pathology. The high bridge centrality of self‐esteem suggests that it may be an important link between perfectionism, mood, and ED symptoms. Future research should investigate the efficacy of targeting multiple psychological factors in the treatment of AN, as well as their potential transdiagnostic relevance. SIGNIFICANCE STATEMENT: Our study contributes to a growing body of work pointing to the relevance of perfectionism, self‐esteem, and anxiety/depression in the symptomatology of anorexia nervosa (AN). The most central symptoms in the network included basing one's value on weight and shape, concern over making mistakes, high personal standards, anxiety, and self‐esteem, indicating that these factors may be important targets to consider in the treatment of AN. [ABSTRACT FROM AUTHOR]

Background: According to the Cognitive–Interpersonal model of anorexia nervosa (AN), the combined influence of cognitive and socio-emotional difficulties would constitute vulnerability and maintaining factors. Poor cognitive flexibility is one of the endophenotypic candidates (i.e., a trait marker) of the disorder, but few studies have examined its association with illness symptom variations, notably weight status. The study aimed to evaluate the relationships between cognitive flexibility performances and nutritional status indices (BMI; body composition) at different times of the disorder. Methods: Cross-sectional and longitudinal associations between cognitive flexibility (TAP 2.1) and nutritional status indices, along with anxious and depressive (HAD) and eating disorder (EDE-Q) symptomatology were investigated using univariate and multivariate analyses in a cohort of AN inpatients evaluated at hospital admission (N = 167) and discharge (N = 94). Results: We found no or negligible associations between nutritional status and HAD or EDE-Q scores or cognitive flexibility performances, either cross-sectionally or longitudinally. Cognitive performances did not significantly differ between the AN subtypes. Conclusions: In agreement with the Cognitive–Interpersonal model of AN, cognitive flexibility is independent of nutritional status, as well as the AN subtype. It is also independent of the levels of anxious, depressive, or ED symptomatology. A new therapeutic approach targeting cognitive flexibility and intolerance to change could benefit severely emaciated people with AN, regardless of disease subtype and level of dysphoria. [ABSTRACT FROM AUTHOR]