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293 results on '"Berthelet, Eric"'

9. Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial

Author

Nichols, Anthony C, Theurer, Julie, Prisman, Eitan, Read, Nancy, Berthelet, Eric, Tran, Eric, Fung, Kevin, de Almeida, John R, Bayley, Andrew, Goldstein, David P, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S Danielle, Winquist, Eric, Hammond, J Alex, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Chen, Jeff, Corsten, Martin, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Parker, Christina, Wehrli, Bret, Kwan, Keith, and Palma, David A

Published
2019
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12. 23 A Retrospective Study Comparing Outcomes in Matched Patients with Poor Prognosis Treated with Targeted Conventional Volumetric Modulated ARC Radiotherapy Versus Whole Brain Radiotherapy for Brain Metastases

Author

Parmar, Gurjit, primary, Kong, Timothy, additional, Hamm, Jeremy, additional, Liu, Mitchell, additional, Lefresne, Shilo, additional, Carolan, Hannah, additional, Berthelet, Eric, additional, Chan, Jessica, additional, and Nichol, Alan, additional

Published
2023
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14. Beyond PACIFIC: Real-World Outcomes of Adjuvant Durvalumab According to Treatment Received and PD-L1 Expression

Author

Denault, Marie-Hélène, primary, Feng, Jamie, additional, Kuang, Shelley, additional, Shokoohi, Aria, additional, Leung, Bonnie, additional, Liu, Mitchell, additional, Berthelet, Eric, additional, Laskin, Janessa, additional, Sun, Sophie, additional, Zhang, Tina, additional, Ho, Cheryl, additional, and Melosky, Barbara, additional

Published
2023
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16. Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony C., Lang, Pencilla, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, de Almeida, John R., Bayley, Andrew, Goldstein, David P., Eskander, Antoine, Husain, Zain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S. Danielle, Mendez, Adrian, Winquist, Eric, Read, Nancy, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Rajaraman, Murali, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, Matthews, T. Wayne, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David A.

Published
2020
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17. Effect of bladder filling on doses to prostate and organs at risk: a treatment planning study

Author

Moiseenko, Vitali, Liu, Mitchell, Kristensen, Sarah, Gelowitz, Gerald, and Berthelet, Eric

Subjects
Medical and Biological Physics, Biomedical and Clinical Sciences, Clinical Sciences, Physical Sciences, Oncology and Carcinogenesis, Cancer, Urologic Diseases, Clinical Research, Prostate Cancer, Aged, Aged, 80 and over, Humans, Male, Middle Aged, Patient Care Planning, Posture, Prostatic Neoplasms, Radiography, Radiotherapy Planning, Computer-Assisted, Rectum, Tattooing, Urinary Bladder, prostate cancer, organ motion, radiotherapy, bladder filling, Other Physical Sciences, Medical Physiology, Nuclear Medicine & Medical Imaging, Medical physiology, Medical and biological physics
Abstract

In the present study, we aimed to evaluate effects of bladder filling on dose-volume distributions for bladder, rectum, planning target volume (PTV), and prostate in radiation therapy of prostate cancer. Patients (n = 21) were scanned with a full bladder, and after 1 hour, having been allowed to void, with an empty bladder. Radiotherapy plans were generated using a four-field box technique and dose of 70 Gy in 35 fractions. First, plans obtained for full- and empty-bladder scans were compared. Second, situations in which a patient was planned on full bladder but was treated on empty bladder, and vice versa, were simulated, assuming that patients were aligned to external tattoos. Doses to the prostate [equivalent uniform dose (EUD)], bladder and rectum [effective dose (Deff)], and normal tissue complication probability (NTCP) were compared. Dose to the small bowel was examined. Mean bladder volume was 354.3 cm3 when full and 118.2 cm3 when empty. Median prostate EUD was 70 Gy for plans based on full- and empty-bladder scans alike. The median rectal Deff was 55.6 Gy for full-bladder anatomy and 56.8 Gy for empty-bladder anatomy, and the corresponding bladder Deff was 29.0 Gy and 49.3 Gy respectively. In 1 patient, part of the small bowel (7.5 cm3) received more than 50 Gy with full-bladder anatomy, and in 6 patients, part (2.5 cm3-30 cm3) received more than 50 Gy with empty-bladder anatomy. Bladder filling had no significant impact on prostate EUD or rectal Deff. A minimal volume of the small bowel received more than 50 Gy in both groups, which is below dose tolerance. The bladder Deff was higher with empty-bladder anatomy; however, the predicted complication rates were clinically insignificant. When the multileaf collimator pattern was applied in reverse, substantial underdosing of the planning target volume (PTV) was observed, particularly for patients with prostate shifts in excess of 0.5 cm in any one direction. However, the prostate shifts showed no correlation with bladder filling, and therefore the PTV underdosing also cannot be related to bladder filling. For some patients, bladder dose-volume constraints were not fulfilled in the worst-case scenario-that is, when a patient planned with full bladder consistently arrived for treatment with an empty bladder.

Published
2007

18. Effect of bladder filling on doses to prostate and organs at risk: a treatment planning study.

Author

Moiseenko, Vitali, Liu, Mitchell, Kristensen, Sarah, Gelowitz, Gerald, and Berthelet, Eric

Subjects
Rectum, Humans, Prostatic Neoplasms, Radiography, Tattooing, Radiotherapy Planning, Computer-Assisted, Posture, Aged, Aged, 80 and over, Middle Aged, Patient Care Planning, Male, Urinary Bladder, prostate cancer, organ motion, radiotherapy, bladder filling, and over, Radiotherapy Planning, Computer-Assisted, Nuclear Medicine & Medical Imaging, Other Physical Sciences, Clinical Sciences, Medical Physiology
Abstract

In the present study, we aimed to evaluate effects of bladder filling on dose-volume distributions for bladder, rectum, planning target volume (PTV), and prostate in radiation therapy of prostate cancer. Patients (n = 21) were scanned with a full bladder, and after 1 hour, having been allowed to void, with an empty bladder. Radiotherapy plans were generated using a four-field box technique and dose of 70 Gy in 35 fractions. First, plans obtained for full- and empty-bladder scans were compared. Second, situations in which a patient was planned on full bladder but was treated on empty bladder, and vice versa, were simulated, assuming that patients were aligned to external tattoos. Doses to the prostate [equivalent uniform dose (EUD)], bladder and rectum [effective dose (Deff)], and normal tissue complication probability (NTCP) were compared. Dose to the small bowel was examined. Mean bladder volume was 354.3 cm3 when full and 118.2 cm3 when empty. Median prostate EUD was 70 Gy for plans based on full- and empty-bladder scans alike. The median rectal Deff was 55.6 Gy for full-bladder anatomy and 56.8 Gy for empty-bladder anatomy, and the corresponding bladder Deff was 29.0 Gy and 49.3 Gy respectively. In 1 patient, part of the small bowel (7.5 cm3) received more than 50 Gy with full-bladder anatomy, and in 6 patients, part (2.5 cm3-30 cm3) received more than 50 Gy with empty-bladder anatomy. Bladder filling had no significant impact on prostate EUD or rectal Deff. A minimal volume of the small bowel received more than 50 Gy in both groups, which is below dose tolerance. The bladder Deff was higher with empty-bladder anatomy; however, the predicted complication rates were clinically insignificant. When the multileaf collimator pattern was applied in reverse, substantial underdosing of the planning target volume (PTV) was observed, particularly for patients with prostate shifts in excess of 0.5 cm in any one direction. However, the prostate shifts showed no correlation with bladder filling, and therefore the PTV underdosing also cannot be related to bladder filling. For some patients, bladder dose-volume constraints were not fulfilled in the worst-case scenario-that is, when a patient planned with full bladder consistently arrived for treatment with an empty bladder.

Published
2006

21. 39: A Novel, Rapid and Simple (RAPPLE) Partial Brain Radiotherapy Technique to Treat Brain Metastasis: A Retrospective Review of Outcomes

Author

Kong, Timothy, primary, Parmar, Gurjit, additional, Carolan, Hannah, additional, Liu, Mitchell, additional, Lefresne, Shilo, additional, Berthelet, Eric, additional, Chan, Jessica, additional, Gondara, Lovedeep, additional, Thomas, Steven, additional, Mestrovic, Ante, additional, and Nichol, Alan, additional

Published
2022
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26. Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Author

Palma, David A., primary, Prisman, Eitan, additional, Berthelet, Eric, additional, Tran, Eric, additional, Hamilton, Sarah, additional, Wu, Jonn, additional, Eskander, Antoine, additional, Higgins, Kevin, additional, Karam, Irene, additional, Poon, Ian, additional, Husain, Zain, additional, Enepekides, Danny, additional, Hier, Michael, additional, Sultanem, Khalil, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Johnson-Obaseki, Stephanie, additional, Odell, Michael, additional, Bayley, Andrew, additional, Dowthwaite, Samuel, additional, Jackson, James E., additional, Dzienis, Marcin, additional, O’Neil, John, additional, Chandarana, Shamir, additional, Banerjee, Robyn, additional, Hart, Robert, additional, Chung, Jeffson, additional, Tenenholtz, Todd, additional, Krishnan, Suren, additional, Le, Hien, additional, Yoo, John, additional, Mendez, Adrian, additional, Winquist, Eric, additional, Kuruvilla, Sara, additional, Stewart, Paul, additional, Warner, Andrew, additional, Mitchell, Sylvia, additional, Chen, Jeff, additional, Parker, Christina, additional, Wehrli, Bret, additional, Kwan, Keith, additional, Theurer, Julie, additional, Sathya, Jinka, additional, Hammond, J. Alex, additional, Read, Nancy, additional, Venkatesan, Varagur, additional, MacNeil, S. Danielle, additional, Fung, Kevin, additional, and Nichols, Anthony C., additional

Published
2022
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28. Comparison of 2-Weekly Versus 4-Weekly Durvalumab Consolidation for Locally Advanced NSCLC Treated With Chemoradiotherapy: A Brief Report

Author

Denault, Marie-Hélène, primary, Kuang, Shelley, additional, Shokoohi, Aria, additional, Leung, Bonnie, additional, Liu, Mitchell, additional, Berthelet, Eric, additional, Laskin, Janessa, additional, Sun, Sophie, additional, Zhang, Tina, additional, Melosky, Barbara, additional, and Ho, Cheryl, additional

Published
2022
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29. Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial

Author

Nichols, Anthony C., primary, Theurer, Julie, additional, Prisman, Eitan, additional, Read, Nancy, additional, Berthelet, Eric, additional, Tran, Eric, additional, Fung, Kevin, additional, de Almeida, John R., additional, Bayley, Andrew, additional, Goldstein, David P., additional, Hier, Michael, additional, Sultanem, Khalil, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Krishnan, Suren, additional, Le, Hien, additional, Yoo, John, additional, MacNeil, S. Danielle, additional, Winquist, Eric, additional, Hammond, J. Alex, additional, Venkatesan, Varagur, additional, Kuruvilla, Sara, additional, Warner, Andrew, additional, Mitchell, Sylvia, additional, Chen, Jeff, additional, Corsten, Martin, additional, Johnson-Obaseki, Stephanie, additional, Odell, Michael, additional, Parker, Christina, additional, Wehrli, Bret, additional, Kwan, Keith, additional, and Palma, David A., additional

Published
2022
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35. 3409: Radiotherapy vs. Trans-Oral Surgery for Treatment De-Escalation in HPV-Associated Oropharyngeal Squamous Cell Carcinoma: Primary Analysis of the ORATOR2 Trial.

Author

Palma, David A., Berthelet, Eric, Hamilton, Sarah, Wu, Jonn, Eskander, Antoine, Higgins, Kevin, Karam, Irene, Hier, Michael, Richardson, Keith, Mlynarek, Alex, Gaudet, Marc, Bayley, Andrew, Dzienis, Marcin, Chandarana, Shamir, Banerjee, Robyn, Hart, Robert, Chung, Jeffson, Le, Hien, Winquist, Eric, and Warner, Andrew

Subjects
*SQUAMOUS cell carcinoma, *RADIOTHERAPY, *SURGERY, *THERAPEUTICS
Published
2024
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36. Additional file 5 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 5. Study Information and Informed Consent Form.

Published
2020
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37. Additional file 4 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Subjects
ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES
Abstract

Additional file 4. Lab Guidelines.

Published
2020
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38. Additional file 6 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 6. World Health Organization Trial Registration Dataset.

Published
2020
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39. Additional file 1 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 1. Treatment Planning Guidelines.

Published
2020
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40. Additional file 2 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 2. Surgical Credentialling Form.

Published
2020
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41. Additional file 3 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, Data_FILES, ComputingMilieux_COMPUTERSANDEDUCATION, ComputingMilieux_MISCELLANEOUS
Abstract

Additional file 3. Schedule of Enrolment, Interventions and Assessments.

Published
2020
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50. CCTG HN.10: A phase II single-arm trial of elective volume adjusted de-escalation radiotherapy (EVADER) in patients with low-risk HPV-related oropharyngeal squamous cell carcinoma (NCT03822897).

Author

Bratman, Scott Victor, primary, Berthelet, Eric, additional, Butler, James B., additional, de Almeida, John R, additional, Karam, Irene, additional, Metser, Ur, additional, Olson, Robert Anton, additional, Pochini, Craig, additional, Waldron, John, additional, Yu, Eugene, additional, McNiven, Andrea, additional, Cheung, Winson Y., additional, Gaudet, Marc, additional, Hunter, Sarah, additional, Chen, Bingshu E., additional, and Parulekar, Wendy R., additional

Published
2020
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