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3. Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation

Author

Kollek, Matthias, primary, Voigt, Gesina, additional, Molnar, Christian, additional, Murad, Fabronia, additional, Bertele, Daniela, additional, Krombholz, Christopher Felix, additional, Bohler, Sheila, additional, Labi, Verena, additional, Schiller, Stefan, additional, Kunze, Mirjam, additional, Geley, Stephan, additional, Niemeyer, Charlotte M., additional, Garcia-Saez, Ana, additional, and Erlacher, Miriam, additional

Published
2017
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4. B‐cell signaling in persistent polyclonal B lymphocytosis (PPBL)

Author

Voelxen, Nadine, primary, Wehr, Claudia, additional, Gutenberger, Sylvia, additional, Keller, Baerbel, additional, Erlacher, Miriam, additional, Dominguez‐Conde, Cecilia, additional, Bertele, Daniela, additional, Emmerich, Florian, additional, Pantic, Milena, additional, Jennings, Stefanie, additional, Rakhmanov, Mirzokhid, additional, Foerster, Christian, additional, Martens, Uwe M, additional, Platzbecker, Uwe, additional, Peter, Hans‐Hartmut, additional, Fisch, Paul, additional, Boztug, Kaan, additional, Eibel, Hermann, additional, Salzer, Ulrich, additional, and Warnatz, Klaus, additional

Published
2016
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5. Transient Bcl-XL Overexpression in Donor Stem Cells Increases Efficacy of Hematopoietic Stem Cell Transplantation without Increasing the Risk of Leukemogenesis

Author

Erlacher, Miriam, primary, Kollek, Matthias, additional, Voigt, Gesina, additional, Bertele, Daniela, additional, Krombholz, Felix, additional, Schiller, Stefan, additional, Garcia-Saez, Ana, additional, Geley, Stephan, additional, Villunger, Andreas, additional, and Niemeyer, Charlotte M, additional

Published
2014
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6. Preclinical Evaluation of 4-Methylthiobutyl Isothiocyanate on Liver Cancer and Cancer Stem Cells with Different p53 Status

Author

Lamy, Evelyn, primary, Hertrampf, Anke, additional, Herz, Corinna, additional, Schüler, Julia, additional, Erlacher, Miriam, additional, Bertele, Daniela, additional, Bakare, Adekunle, additional, Wagner, Meike, additional, Weiland, Timo, additional, Lauer, Ulrich, additional, Drognitz, Oliver, additional, Huber, Roman, additional, Rohn, Sascha, additional, Giesemann, Torsten, additional, and Mersch-Sundermann, Volker, additional

Published
2013
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7. Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3‐only proteins Bim and Bmf

Author

Labi, Verena, primary, Bertele, Daniela, additional, Woess, Claudia, additional, Tischner, Denise, additional, Bock, Florian J., additional, Schwemmers, Sven, additional, Pahl, Heike L., additional, Geley, Stephan, additional, Kunze, Mirjam, additional, Niemeyer, Charlotte M., additional, Villunger, Andreas, additional, and Erlacher, Miriam, additional

Published
2012
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10. Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

Author

Krombholz CF, Aumann K, Kollek M, Bertele D, Fluhr S, Kunze M, Niemeyer CM, Flotho C, and Erlacher M

Subjects
Animals, Biopsy, Disease Models, Animal, Graft Survival, Graft vs Host Disease etiology, Humans, Immunohistochemistry, Leukemia, Myelomonocytic, Juvenile mortality, Mice, Mice, Knockout, Neoplasm Invasiveness, Neoplastic Stem Cells metabolism, T-Lymphocytes immunology, T-Lymphocytes metabolism, Transplantation, Heterologous, DNA-Binding Proteins deficiency, Interleukin Receptor Common gamma Subunit deficiency, Leukemia, Myelomonocytic, Juvenile genetics, Leukemia, Myelomonocytic, Juvenile pathology, Neoplasm Transplantation adverse effects
Abstract

Juvenile myelomonocytic leukemia is a clonal malignant disease affecting young children. Current cure rates, even with allogeneic hematopoietic stem cell transplantation, are no better than 50%-60%. Pre-clinical research on juvenile myelomonocytic leukemia is urgently needed for the identification of novel therapies but is hampered by the unavailability of culture systems. Here we report a xenotransplantation model that allows long-term in vivo propagation of primary juvenile myelomonocytic leukemia cells. Persistent engraftment of leukemic cells was achieved by intrahepatic injection of 1×10(6) cells into newborn Rag2(-/-)γc(-/-) mice or intravenous injection of 5×10(6) cells into 5-week old mice. Key characteristics of juvenile myelomonocytic leukemia were reproduced, including cachexia and clonal expansion of myelomonocytic progenitor cells that infiltrated bone marrow, spleen, liver and, notably, lung. Xenografted leukemia cells led to reduced survival of recipient mice. The stem cell character of juvenile myelomonocytic leukemia was confirmed by successful serial transplantation that resulted in leukemia cell propagation for more than one year. Independence of exogenous cytokines, low donor cell number and slowly progressing leukemia are advantages of the model, which will serve as an important tool to research the pathophysiology of juvenile myelomonocytic leukemia and test novel pharmaceutical strategies such as DNA methyltransferase inhibition., (Copyright© Ferrata Storti Foundation.)

Published
2016
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