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O objetivo da entrevista é analisar as concepções de avaliação e qualidade educacional na contemporaneidade à luz das reflexões sobre as políticas públicas brasileiras influenciadas pelo desenvolvimento global da sociedade capitalista. A entrevista discute as causas estruturais da reforma empresarial da educação e sua intencionalidade, exemplificando os riscos com o desenvolvimento desta política em seu país de origem - a América do Norte – e que se encontra em estágio mais avançado, permitindo analisar suas consequências e desdobramentos na política educacional brasileira, instigados pelas estratégias no campo da avaliação e qualidade educacional. O entrevistado aponta impactos e dilemas da reforma empresarial no contexto brasileiro e indica caminhos de resistência, propondo conceitos alternativos para os processos de avaliação que contrariam a noção predominante da “qualidade empresarial” para a educação e fortalecem a luta e defesa da qualidade social da escola pública.

Já se vão muitos anos desde que as políticas neoliberais buscam se apropriar da avaliação da qualidade da escola, naturalizando formas de controle vertical sobre o trabalho docente à guisa de promover maior qualidade de ensino. Para tal, muito tempo e dinheiro públicos têm sido dispendidos de modo a estampar, por via de resultados dos estudantes em testes estandardizados, um retrato fiel, e quase ortodoxo, do quanto a escola e seus profissionais têm falhado na execução de sua função precípua, qual seja, garantir que as crianças e jovens aprendam. Parece se homogeneizar a ideia de que, quanto mais se avalia, mais qualidade se produz. Nesse sentido, a escola, atrelada à lógica empresarial, passa a ser qualificada pela produtividade, eficiência e competência numa perspectiva mercantil e tecnocrática.

BackgroundTotal-body positron emission tomography/computed tomography (PET/CT) scanners are characterized by higher signal collection efficiency and greater spatial resolution compared to conventional scanners, allowing for delayed imaging and improved image quality. These advantages may also lead to better detection of physiological processes that diagnostic imaging professionals should be aware of. The gallbladder (GB) is not usually visualized as an 18F-2-fluorodeoxyglucose (18F-FDG)-avid structure in routine clinical PET/CT studies; however, with the total-body PET/CT, we have been increasingly visualizing GB activity without it being involved in an inflammatory or neoplastic process. The aim of this study was to report visualization rates and characteristics of GB 18F-FDG uptake observed in both healthy and oncological subjects scanned on a total-body PET/CT system.Materials and methodsScans from 73 participants (48 healthy and 25 with newly diagnosed lymphoma) who underwent 18F-FDG total-body PET/CT were retrospectively reviewed. Subjects were scanned at multiple timepoints up to 3 h post-injection. Gallbladder 18F-FDG activity was graded using liver uptake as a reference, and the pattern was qualified as present in the wall, lumen, or both. Participants' characteristics, such as age, sex, body-mass index, blood glucose, and other clinical parameters, were collected to assess for any significant correlation with GB 18F-FDG uptake.ResultsAll 73 subjects showed GB uptake at one or more imaging timepoints. An increase in uptake intensity overtime was observed up until the 180-min scan, and the visualization rate of GB 18F-FDG uptake was 100% in the 120- and 180-min post-injection scans. GB wall uptake was detected in a significant number of patients (44/73, 60%), especially at early timepoint scans, whereas luminal activity was detected in 71/73 (97%) subjects, especially at later timepoint scans. No significant correlation was found between GB uptake intensity/pattern and subjects' characteristics.ConclusionThe consistent observation of GB 18F-FDG uptake recorded in this study in healthy participants and subjects with a new oncological diagnosis indicates that this is a normal physiologic finding rather than representing an exception.

Abstract The new generation of heterogeneous CPU/GPU computer systems offer much greater computational performance but are not yet widely used for climate modeling. One reason for this is that traditional climate models were written before GPUs were available and would require an extensive overhaul to run on these new machines. In addition, even conventional “high–resolution” simulations don't currently provide enough parallel work to keep GPUs busy, so the benefits of such overhaul would be limited for the types of simulations climate scientists are accustomed to. The vision of the Simple Cloud‐Resolving Energy Exascale Earth System (E3SM) Atmosphere Model (SCREAM) project is to create a global atmospheric model with the architecture to efficiently use GPUs and horizontal resolution sufficient to fully take advantage of GPU parallelism. After 5 years of model development, SCREAM is finally ready for use. In this paper, we describe the design of this new code, its performance on both CPU and heterogeneous machines, and its ability to simulate real‐world climate via a set of four 40 day simulations covering all 4 seasons of the year.

O artigo apresenta o mapeamento da avaliação em larga escala de competências socioemocionais desenvolvida pelo Instituto Ayrton Senna (IAS) nas redes estaduais de ensino na região Sudeste do Brasil com o objetivo de analisar essa proposta avaliativa, especificamente no estado de São Paulo. Por meio de pesquisa qualitativa em documentos institucionais e materiais de comunicação das secretarias de educação e do IAS (totalizando 40), desvela-se a presença do instituto na região Sudeste e, em São Paulo, efetivamente a partir da aplicação da avaliação socioemocional em larga escala. Dessa forma, evidencia-se a incidência do IAS na política educacional para os anos finais do Ensino Fundamental e Ensino Médio disseminando as ideias do setor empresarial/privado na educação pública. Palavras-chave: Avaliação das competências socioemocionais. Política educacional. Privatização.

RESUMO Este artigo destaca as relações entre accountability e a avaliação de sistema, a partir das análises das avaliações da educação obrigatória do Brasil e do Uruguai. As avaliações de sistema ganham destaque no contexto histórico-político e se desdobram diferentemente em cada país. A pesquisa qualitativa foi desenvolvida a partir do estudo de dois casos (Brasil e Uruguai), por meio de levantamento documental e bibliográfico, e, análise de conteúdo. Entende-se que estas avaliações podem apontar para limitações no que tange à educação de qualidade social.

In pursuing quick and precise progressive flooding simulations for decision-making support, the linearised method has emerged and undergone refinement in recent years, becoming a reliable tool, especially for onboard decision support. This study consolidates and enhances the modelling approach based on a system of differential-algebraic equations capable of accommodating compartments filled with floodwater. The system can be linearised to permit analytical solutions, facilitating the utilization of larger time increments compared to conventional solvers for differential equations. Performance enhancements are achieved through the implementation of an adaptive time-step mechanism during the integration process. Furthermore, here, a correction coefficient for opening areas is introduced to enable the accurate modelling of free outflow scenarios, thereby mitigating issues associated with the assumption of deeply submerged openings used in governing equations. Experimental validation is conducted to compare the method’s efficacy against recent model-scale tests, specifically emphasising the improvements stemming from the correction for free outflow.

IntroductionThe loose-patch clamp technique was first developed and used in native amphibian skeletal muscle (SkM), offering useful features complementing conventional sharp micro-electrode, gap, or conventional patch voltage clamping. It demonstrated the feedback effects of pharmacological modification of ryanodine receptor (RyR)-mediated Ca2+ release on the Na+ channel (Nav1.4) currents, initiating excitation–contraction coupling in native murine SkM. The effects of the further RyR and Ca2+-ATPase (SERCA) antagonists, dantrolene and cyclopiazonic acid (CPA), additionally implicated background tubular-sarcoplasmic Ca2+ domains in these actions.Materials and methodsWe extend the loose-patch clamp approach to ion current measurements in murine hippocampal brain slice cornu ammonis-1 (CA1) pyramidal neurons. We explored the effects on Na+ currents of pharmacologically manipulating RyR and SERCA-mediated intracellular store Ca2+ release and reuptake. We adopted protocols previously applied to native skeletal muscle. These demonstrated Ca2+-mediated feedback effects on the Na+ channel function.ResultsExperiments applying depolarizing 15 ms duration loose-patch clamp steps to test voltages ranging from −40 to 120 mV positive to the resting membrane potential demonstrated that 0.5 mM caffeine decreased inward current amplitudes, agreeing with the previous SkM findings. It also decreased transient but not prolonged outward current amplitudes. However, 2 mM caffeine affected neither inward nor transient outward but increased prolonged outward currents, in contrast to its increasing inward currents in SkM. Furthermore, similarly and in contrast to previous SkM findings, both dantrolene (10 μM) and CPA (1 μM) pre-administration left both inward and outward currents unchanged. Nevertheless, dantrolene pretreatment still abrogated the effects of subsequent 0.5- and 2-mM caffeine challenges on both inward and outward currents. Finally, CPA abrogated the effects of 0.5 mM caffeine on both inward and outward currents, but with 2 mM caffeine, inward and transient outward currents were unchanged, but sustained outward currents increased.ConclusionWe, thus, extend loose-patch clamping to establish pharmacological properties of murine CA1 pyramidal neurons and their similarities and contrasts with SkM. Here, evoked though not background Ca2+-store release influenced Nav and Kv excitation, consistent with smaller contributions of background store Ca2+ release to resting [Ca2+]. This potential non-canonical mechanism could modulate neuronal membrane excitability or cellular firing rates.

BackgroundSeveral recent studies have proposed the possible application of positron emission tomography/computed tomography (PET/CT) administering radiolabelled fibroblast-activation protein (FAP) inhibitors for various forms of thyroid cancer (TC), including differentiated TC (DTC), and medullary TC (MTC).MethodsThe authors conducted an extensive literature search of original studies examining the effectiveness of FAP-guided PET/CT in patients with TC. The papers included were original publications exploring the use of FAP-targeted molecular imaging in restaging metastatic DTC and MTC patients.ResultsA total of 6 studies concerning the diagnostic yield of FAP-targeted PET/CT in TC (274 patients, of which 247 DTC and 27 MTC) were included in this systematic review. The included articles reported high values of FAP-targeted PET/CT detection rates in TC, ranging from 81 to 100% in different anatomical sites and overall superior to the comparative imaging method.ConclusionAlthough there are promising results, the existing literature on the diagnostic accuracy of FAP-guided PET in this context is still quite limited. To thoroughly evaluate its potential significance in TC patients, it is needed to conduct prospective randomized multicentric trials.

Contaminants of emerging concern (CECs) and their respective transformation products (TPs) formed following photodegradation pose considerable threats to the environment and our health. The formation of TPs during UV-LED-based degradation of three target pollutants in the EU Watch List of CECs was accessed by LC-MS-Orbitrap, and their reaction pathways were elucidated. The influence of different matrices and treatments of choice on TP formation was investigated. Results showed that matrix changes did not produce different reaction pathways during UV-A photocatalysis, although plots of TP peak areas vs. time were different for each case. A new TP was found for the antidepressant venlafaxine, (1-[2-(dimethylnitroryl)-1-(4-methoxyphenyl)ethyl]cyclohexanol. When comparing UV-A photocatalysis with UV-C photolysis, dissimilar pathways were observed due to the distinct reaction mechanisms of each process, since photocatalysis, unlike photolysis, relies on radical-based reaction routes. Different levels of confidence were obtained for each TP depending on the availability of MS2 data in the literature and of standards for comparison. All the found TPs had similar molecular masses in comparison to their respective parent compounds. Most of the TPs remained in the effluent after 6 hours of photodegradation, which highlights the importance of their control, close-monitoring, and further toxicity assessments. HIGHLIGHTS Detection of transformation products of contaminants of emerging concern in water.; Elucidation of reaction pathways for photolysis and photocatalysis.; A new transformation product found for venlafaxine.; No difference in detected compounds for tap and ultrapure water.;

This paper describes the first implementation of the Δx = 3.25 km version of the Energy Exascale Earth System Model (E3SM) global atmosphere model and its behavior in a 40-day prescribed-sea-surface-temperature simulation (January 20 through February 28, 2020). This simulation was performed as part of the DYnamics of the Atmospheric general circulation Modeled On Non-hydrostatic Domains (DYAMOND) Phase 2 model intercomparison. Effective resolution is found to be (Formula presented.) the horizontal dynamics grid resolution despite using a coarser grid for physical parameterizations. Despite this new model being in an immature and untuned state, moving to 3.25 km grid spacing solves several long-standing problems with the E3SM model. In particular, Amazon precipitation is much more realistic, the frequency of light and heavy precipitation is improved, agreement between the simulated and observed diurnal cycle of tropical precipitation is excellent, and the vertical structure of tropical convection and coastal stratocumulus look good. In addition, the new model is able to capture the frequency and structure of important weather events (e.g., tropical cyclones, extratropical cyclones including atmospheric rivers, and cold air outbreaks). Interestingly, this model does not get rid of the erroneous southern branch of the intertropical convergence zone nor the tendency for strongest convection to occur over the Maritime Continent rather than the West Pacific, both of which are classic climate model biases. Several other problems with the simulation are identified, underscoring the fact that this model is a work in progress.

Background: The prognostic role of imaging with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in oropharynx cancer (OPC) has been demonstrated in the past. The aim of this study was to assess the prognostic impact of both baseline and post-treatment PET/CT in patients with OPC and treated with chemo- and/or radiotherapy. Methods: The PET/CT parameters of scans performed before and after therapy were collected and analyzed to find significant prognosticators for progression-free survival (PFS) and overall survival (OS). Human papillomavirus (HPV) infection’s influence on the prognosis was also taken into account. Results: A total of 66 patients were included in the study. The staging volumetric parameters of PET/CT were significant prognosticators for OS, while the same parameters were affordable predictors for PFS at the restaging evaluation. No significant correlations between HPV infection and PET/CT parameters were reported. Conclusion: The prognostic role of volumetric [18F]FDG PET/CT parameters in patients with OPC was reported.

Background: Recent studies have suggested using positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals for the detection of salivary gland malignancies (SGM), particularly adenoid-cystic carcinoma (ACC). Methods: The authors conducted an extensive review of the scientific literature to examine the potential diagnostic role of PET/CT using PSMA-targeting radiopharmaceuticals in salivary gland malignancies (SGMs) and adenoid cystic carcinoma (ACC). This study included newly diagnosed SGM patients and those with disease recurrence in their imaging evaluation. Results: This updated systematic review included a total of six studies that examined the diagnostic performance of PSMA-targeted PET/CT in ACC. The articles provided evidence of a high detection rate of PSMA-targeting PET/CT in ACC across all clinical contexts examined. SGMs other than ACC exhibited poorer diagnostic performance. Conclusions: PSMA-targeted PET/CT seems promising in detecting ACC lesions; moreover, PSMA appears to be a suitable potential target for radioligand therapy. Prospective multicentric studies are warranted to strengthen the role of PSMA-targeting radiopharmaceuticals in ACC, as both diagnostic and theragnostic agents.

El artículo analiza las trayectorias de cuatro mujeres italianas exiliadas durante la dictadura fascista en Italia: Joyce Lussu, Vera Funaro Modigliani, Graziella Sechi y Margherita Grassini Sarfatti. A partir de estos casos muy diferentes entre sí, el objetivo del artículo es abordar la cuestión de la relación entre género y exilio. Por un lado, plantea algunos interrogantes sobre el peso relativo de este factor frente a otros, como el estatus socioeconómico, en la determinación del compromiso político de las mujeres en el exilio. Por otro lado, trata de entender si y cómo el exilio cambió las relaciones de género en la pareja.