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206 results on '"Berretta, Nicola"'

2. Systemic inflammation triggers long-lasting neuroinflammation and accelerates neurodegeneration in a rat model of Parkinson's disease overexpressing human alpha-synuclein

Author

Cenere, Mariangela Massaro, primary, Tiberi, Marta, additional, Paldino, Emanuela, additional, D’Addario, Sebastian Luca, additional, Federici, Mauro, additional, Giacomet, Cecilia, additional, Cutuli, Debora, additional, Matteocci, Alessandro, additional, Cossa, Francesca, additional, Zarrilli, Beatrice, additional, Ledonne, Ada, additional, Petrosini, Laura, additional, Berretta, Nicola, additional, Fusco, Francesca Romana, additional, Chiurchiù, Valerio, additional, and Mercuri, Nicola B., additional

Published
2024
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7. Morpho‐Functional Changes of Nigral Dopamine Neurons in an α‐Synuclein Model of Parkinson's Disease

Author

Ledonne, Ada, primary, Massaro Cenere, Mariangela, additional, Paldino, Emanuela, additional, D'Angelo, Vincenza, additional, D'Addario, Sebastian Luca, additional, Casadei, Nicolas, additional, Nobili, Annalisa, additional, Berretta, Nicola, additional, Fusco, Francesca R., additional, Ventura, Rossella, additional, Sancesario, Giuseppe, additional, Guatteo, Ezia, additional, and Mercuri, Nicola Biagio, additional

Published
2022
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8. Neuropathology of the Basal Ganglia in SNCA Transgenic Rat Model of Parkinson’s Disease: Involvement of Parvalbuminergic Interneurons and Glial-Derived Neurotropic Factor

Author

Paldino, Emanuela, primary, D’angelo, Vincenza, additional, Massaro Cenere, Mariangela, additional, Guatteo, Ezia, additional, Barattucci, Simone, additional, Migliorato, Giorgia, additional, Berretta, Nicola, additional, Riess, Olaf, additional, Sancesario, Giuseppe, additional, Mercuri, Nicola Biagio, additional, and Fusco, Francesca Romana, additional

Published
2022
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11. Learning Discloses Abnormal Structural and Functional Plasticity at Hippocampal Synapses in the APP23 Mouse Model of Alzheimer's Disease

Author

Middei, Silvia, Roberto, Anna, and Berretta, Nicola

Abstract

B6-Tg/Thy1APP23Sdz (APP23) mutant mice exhibit neurohistological hallmarks of Alzheimer's disease but show intact basal hippocampal neurotransmission and synaptic plasticity. Here, we examine whether spatial learning differently modifies the structural and electrophysiological properties of hippocampal synapses in APP23 and wild-type mice. While no genotypic difference was found in the pseudotrained mice, training elicited a stronger increase in spine density and a more rapid decay of long-term potentiation (LTP) in APP23 mutants. Thus, learning discloses mutation-related abnormalities regarding dendritic spine formation and LTP persistence, thereby suggesting that although unaltered in naive synapses, plasticity becomes defective at the time it comes into play.

Published
2010
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19. Morpho‐Functional Changes of Nigral Dopamine Neurons in an α‐Synuclein Model of Parkinson's Disease.

Author

Ledonne, Ada, Massaro Cenere, Mariangela, Paldino, Emanuela, D'Angelo, Vincenza, D'Addario, Sebastian Luca, Casadei, Nicolas, Nobili, Annalisa, Berretta, Nicola, Fusco, Francesca R., Ventura, Rossella, Sancesario, Giuseppe, Guatteo, Ezia, and Mercuri, Nicola Biagio

Abstract

Background: The accumulation of α‐synuclein (α‐syn) fibrils in intraneuronal inclusions called Lewy bodies and Lewy neurites is a pathological signature of Parkinson's disease (PD). Although several aspects linked to α‐syn–dependent pathology (concerning its spreading, aggregation, and activation of inflammatory and neurodegenerative processes) have been under intense investigation, less attention has been devoted to the real impact of α‐syn overexpression on structural and functional properties of substantia nigra pars compacta (SNpc) dopamine (DA) neurons, particularly at tardive stages of α‐syn buildup, despite this has obvious relevance to comprehending mechanisms beyond PD progression. Objectives: We aimed to determine the consequences of a prolonged α‐syn overexpression on somatodendritic morphology and functions of SNpc DA neurons. Methods: We performed immunohistochemistry, stereological DA cell counts, analyses of dendritic arborization, ex vivo patch‐clamp recordings, and in vivo DA microdialysis measurements in a 12‐ to 13‐month‐old transgenic rat model overexpressing the full‐length human α‐syn (Snca+/+) and age‐matched wild‐type rats. Results: Aged Snca+/+ rats have mild loss of SNpc DA neurons and decreased basal DA levels in the SN. Residual nigral DA neurons display smaller soma and compromised dendritic arborization and, in parallel, increased firing activity, switch in firing mode, and hyperexcitability associated with hypofunction of fast activating/inactivating voltage‐gated K+ channels and Ca2+‐ and voltage‐activated large conductance K+ channels. These intrinsic currents underlie the repolarization/afterhyperpolarization phase of action potentials, thus affecting neuronal excitability. Conclusions: Besides clarifying α‐syn–induced pathological landmarks, such evidence reveals compensatory functional mechanisms that nigral DA neurons could adopt during PD progression to counteract neurodegeneration. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Correction to: MicroRNA-34 Contributes to the Stress-related Behavior and Affects 5-HT Prefrontal/GABA Amygdalar System through Regulation of Corticotropin-releasing Factor Receptor 1

Author

Andolina, Diego, primary, Di Segni, Matteo, additional, Accoto, Alessandra, additional, Lo Iacono, Luisa, additional, Borreca, Antonella, additional, Ielpo, Donald, additional, Berretta, Nicola, additional, Perlas, Emerald, additional, Puglisi-Allegra, Stefano, additional, and Ventura, Rossella, additional

Published
2019
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33. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

Author

Bashir, Zafar I., Davies, Ceri H., Berretta, Nicola, Irving, Andrew J., Seal, Andrew J., Henley, Jeremy M., Jane, David E., and Watkins, Jeffrey C.

Subjects
Methyl aspartate -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

(RS)-alpha-methyl-4-carboxy phenylglycine is used to examine the nature of the involvement of mGluRs in long-term potentiation (LTP). It is a specific mGluR antagonist in the Lippocampus. Synaptic activation of mGluRs is necessary for the induction of both NMDA receptor-dependent and NMDA receptor-independent forms of LTP in the Lippocampus.

Published
1993

36. NMDA receptors and long-term potentiation in the hippocampus

Author

BASHIR, ZAFAR I., primary, BERRETTA, NICOLA, additional, BORTOLOTTO, ZUNER A., additional, CLARK, KATH, additional, DAVIES, CERI H., additional, FRENGUELLI, BRUNO G., additional, HARVEY, JENNI, additional, POTIER, BRIGITTE, additional, and COLLINGRIDGE, GRAHAM L., additional

Published
1995
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37. Reversal of dopamine-mediated firing inhibition through activation of the dopamine transporter in substantia nigra pars compacta neurons

Author

Aversa, Daniela, Martini, Alessandro, Guatteo, Ezia, Pisani, Antonio, Mercuri, Nicola Biagio, and Berretta, Nicola

Subjects
D2 receptors, Neurons, Dopamine Plasma Membrane Transport Proteins, Patch-Clamp Techniques, Receptors, Dopamine D2, Parkinson's disease, Dopamine, monoamino oxidases, Settore BIO/14, In Vitro Techniques, Research Papers, Mice, Inbred C57BL, Substantia Nigra, Mice, nervous system, Mesencephalon, dopamine, dopamine transporter, Animals, Settore MED/26 - Neurologia, Monoamine Oxidase
Abstract

BACKGROUND AND PURPOSE: One of the hallmarks of ventral midbrain dopamine‐releasing neurons is membrane hyperpolarization in response to stimulation of somato‐dendritic D(2) receptors. At early postnatal age, under sustained dopamine, this inhibitory response is followed by a slow recovery, resulting in dopamine inhibition reversal (DIR). In the present investigation, we aimed to get a better insight into the cellular mechanisms underlying DIR. EXPERIMENTAL APPROACH: We performed single‐unit extracellular recordings with a multi‐electrode array device and conventional patch‐clamp recordings on midbrain mouse slices. KEY RESULTS: While continuous dopamine (100 μM) perfusion gave rise to firing inhibition that recovered in 10 to 15 min, the same effect was not obtained with the D(2) receptor agonist quinpirole (100 nM). Moreover, firing inhibition caused by the GABA(B) receptor agonist baclofen (300 nM) was reversed by dopamine (100 μM), albeit D(2) receptors had been blocked by sulpiride (10 μM). Conversely, the block of the dopamine transporter (DAT) with cocaine (30 μM) prevented firing recovery by dopamine under GABA(B) receptor stimulation. Accordingly, in whole‐cell recordings from single cells, the baclofen‐induced outward current was counteracted by dopamine (100 μM) in the presence of sulpiride (10 μM), and this effect was prevented by the DAT antagonists cocaine (30 μM) and GBR12909 (2 μM). CONCLUSIONS AND IMPLICATIONS: Our results indicate that the DAT plays a major role in DIR, mediating it under conditions of sustained dopamine exposure, and point to DAT as an important target for pharmacological therapies leading to prolonged enhancement of the dopaminergic signal.

Published
2018

39. Astrocyte-dependent vulnerability to excitotoxicity in spermine oxidase overexpressing mouse

Author

Cervetto, Chiara, Vergani, Laura, Passalacqua, Mario, Ragazzoni, Milena, Venturini, Arianna, Cecconi, Francesco, Berretta, Nicola, Mercuri, Nicola, D’Amelio, Marcello, Maura, Guido, Voci, Adriana, Marcoli, Manuela, MARIOTTINI, Paolo, CERVELLI, MANUELA, Cervetto, Chiara, Vergani, Laura, Passalacqua, Mario, Ragazzoni, Milena, Venturini, Arianna, Cecconi, Francesco, Berretta, Nicola, Mercuri, Nicola, D’Amelio, Marcello, Maura, Guido, Mariottini, Paolo, Voci, Adriana, Marcoli, Manuela, and Cervelli, Manuela

Published
2015

40. Dopamine loss alters the hippocampus-nucleus accumbens synaptic transmission in the Tg2576 mouse model of Alzheimer's disease

Author

Cordella, Alberto, primary, Krashia, Paraskevi, additional, Nobili, Annalisa, additional, Pignataro, Annabella, additional, La Barbera, Livia, additional, Viscomi, Maria Teresa, additional, Valzania, Alessandro, additional, Keller, Flavio, additional, Ammassari-Teule, Martine, additional, Mercuri, Nicola Biagio, additional, Berretta, Nicola, additional, and D'Amelio, Marcello, additional

Published
2018
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42. Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

Author

Nobili, Annalisa, primary, Latagliata, Emanuele Claudio, additional, Viscomi, Maria Teresa, additional, Cavallucci, Virve, additional, Cutuli, Debora, additional, Giacovazzo, Giacomo, additional, Krashia, Paraskevi, additional, Rizzo, Francesca Romana, additional, Marino, Ramona, additional, Federici, Mauro, additional, De Bartolo, Paola, additional, Aversa, Daniela, additional, Dell’Acqua, Maria Concetta, additional, Cordella, Alberto, additional, Sancandi, Marco, additional, Keller, Flavio, additional, Petrosini, Laura, additional, Puglisi-Allegra, Stefano, additional, Mercuri, Nicola Biagio, additional, Coccurello, Roberto, additional, Berretta, Nicola, additional, and D’Amelio, Marcello, additional

Published
2017
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46. Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse

Author

Cervetto, Chiara, primary, Vergani, Laura, additional, Passalacqua, Mario, additional, Ragazzoni, Milena, additional, Venturini, Arianna, additional, Cecconi, Francesco, additional, Berretta, Nicola, additional, Mercuri, Nicola, additional, D’Amelio, Marcello, additional, Maura, Guido, additional, Mariottini, Paolo, additional, Voci, Adriana, additional, Marcoli, Manuela, additional, and Cervelli, Manuela, additional

Published
2015
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48. On the properties of identified dopaminergic neurons in the mouse substantia nigra and ventral tegmental area.

Author

Krashia, Paraskevi, Martini, Alessandro, Nobili, Annalisa, Aversa, Daniela, D'Amelio, Marcello, Berretta, Nicola, Guatteo, Ezia, Mercuri, Nicola Biagio, and Bolam, Paul

Subjects
DOPAMINERGIC neurons, SUBSTANTIA nigra, HYPERPOLARIZATION (Cytology), MESENCEPHALON, LABORATORY mice, PHYSIOLOGY
Abstract

We studied the properties of dopaminergic neurons in the substantia nigra pars compacta ( SNpc) and ventral tegmental area ( VTA) in mice expressing the enhanced green fluorescent protein ( eGFP) under the control of the tyrosine hydroxylase promoter ( TH- GFP). By using a practical map of cell positioning in distinct SNpc and VTA subregions in horizontal midbrain slices we saw that the spontaneous firing, membrane properties, cell body size and magnitude of the hyperpolarization-activated current ( Ih) in TH- GFP-positive neurons ( TH- GFP+) vary significantly among subregions, following a mediolateral gradient. Block of Ih with Zd7288 inhibited firing in the most lateral subregions, but had little effect in the intermediate/medial VTA. In addition, TH- GFP+ cells were excited by Met5-Enkephalin. Extracellular recordings from a large neuron number showed that all TH- GFP+ cells were inhibited by dopamine, suggesting that this is a reliable approach for identifying dopaminergic neurons in vitro. Simultaneous recordings from dopamine-sensitive and dopamine-insensitive neurons showed that dopamine-insensitive cells (putative non-dopaminergic neurons) are unaffected by Zd7288 but inhibited by Met5-Enkephalin. Under patch-clamp, dopamine generated a quantitatively similar outward current in most TH- GFP+ neurons, although medial VTA cells showed reduced dopamine sensitivity. Pargyline prolonged the dopamine current, whereas cocaine enhanced dopamine-mediated responses in both the SNpc and the VTA. Our work provides new insights into the variability in mouse midbrain dopaminergic neurons along the medial-lateral axis and points to the necessity of a combination of different electrophysiological and pharmacological approaches for reliably identifying these cells to distinguish them from non-dopaminergic neurons in the midbrain. [ABSTRACT FROM AUTHOR]

Published
2017
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49. Interleukin-1β Promotes Long-Term Potentiation in Patients with Multiple Sclerosis

Author

Mori, Francesco, primary, Nisticò, Robert, additional, Mandolesi, Georgia, additional, Piccinin, Sonia, additional, Mango, Dalila, additional, Kusayanagi, Hajime, additional, Berretta, Nicola, additional, Bergami, Alessandra, additional, Gentile, Antonietta, additional, Musella, Alessandra, additional, Nicoletti, Carolina G., additional, Nicoletti, Ferdinando, additional, Buttari, Fabio, additional, Mercuri, Nicola B., additional, Martino, Gianvito, additional, Furlan, Roberto, additional, and Centonze, Diego, additional

Published
2013
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50. Inflammation Subverts Hippocampal Synaptic Plasticity in Experimental Multiple Sclerosis

Author

Nisticò, Robert, primary, Mango, Dalila, additional, Mandolesi, Georgia, additional, Piccinin, Sonia, additional, Berretta, Nicola, additional, Pignatelli, Marco, additional, Feligioni, Marco, additional, Musella, Alessandra, additional, Gentile, Antonietta, additional, Mori, Francesco, additional, Bernardi, Giorgio, additional, Nicoletti, Ferdinando, additional, Mercuri, Nicola B., additional, and Centonze, Diego, additional

Published
2013
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