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A new acylated flavonol triglycoside, quercetin-3-O-(5′-p-hydroxybenzoyl)-β-D-apiofuranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-galactopyranoside (1), was isolated from the aerial parts of Astragalus armatus subsp. numidicus (Murb.) Emb. & Maire as well as ten known compounds, one phenolic compound, one flavonol-aglycone and eight flavonol-glycosides distributed into two monoglycosides, three diglycosides and three triosides. Their structures were mainly determined by 1D- and 2D-NMR experiments (1H,13C, COSY, HSQC, HMBC). The chloroform, ethyl acetate, n-butanol and hydroethanol extracts were tested for their antioxidant activity using five methods (DPPH, ABTS, Reducing power, CUPRAC and Phenanthroline). The ethyl acetate extract was the most active in CUPRAC (A0.5: 50.28 ± 2.16 µg/mL), ABTS (IC50: 49.73 ± 1.55 µg/mL) and Reducing power (A0.5: 58.13 ± 4.35 µg/mL) assays, whereas the hydroethanol and n-BuOH exhibited the highest activity in the Phenanthroline assay (A0.5: 9.93 ± 0.16) and (A0.5: 10.27 ± 0.44 µg/mL), respectively. [ABSTRACT FROM AUTHOR]

A pentacyclic triterpene, named salvibuchanic acid (1), together with five known compounds, were isolated from the roots of Salvia buchananii Hedge (Lamiaceae). The structural characterisation of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HRESIMS experiments. The lupane triterpene (1) and hyptadienic acid (2) were investigated for their potential cytotoxic activity on Jurkat, HeLa and MCF7 cell lines. Both compounds showed an interesting antiproliferative activity with similar potency in all cell lines. By means of flow cytometric studies, hyptadienic acid (2) induced in HeLa cells a S cell cycle block, while 1 elicited both cytostatic and cytotoxic responses. [ABSTRACT FROM AUTHOR]

A new 2-alkylhydroquinone glucoside, 1-O-β-d-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl)benzene (1), in addition to nine known compounds were isolated from the aerial parts of Phagnalon saxatile (L.) Cass. (Asteraceae). Their structures were identified based on spectroscopic methods including 1D and 2D NMR, mass spectrometry (HR-ESI-MS), UV spectral analyses and by comparison with literature data. The cytotoxic activity of three isolated compounds (1-3) was evaluated against fibrosarcoma (HT1080), human lung cancer (A549) and breast cancer (MCF7) cell lines. [ABSTRACT FROM AUTHOR]

Five flavonol glycosides, kaempferol 3,7-di-O-α-L-rhamnopyranoside (1), isorhamnetin 3,7-di-O-α-L- rhamnopyranoside (2), kaempferol 3-O-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside (3), isorhamnetin 3-O-β-D- glucopyranoside-7-O-α-L-rhamnopyranoside(4), Kaempferol 3-O-β-xylopyranosyl-(1'''→2'')-O-α-L-rhamnopyranoside- 7-O-α-L-rhamnopyranoside (5), have been isolated from the aerial parts of Reseda arabica. Their structures were established on the basis of physical and spectroscopic analysis, and by comparison with the literature data. [ABSTRACT FROM AUTHOR]

The article offers information on a research conducted by the authors related to convolvulus supinus' antioxidant activity and flavonol glycosides. Aerial parts of the plant were macerated in a methanolic solution and the extract was concentracted under low pressure. It discusses how acid hydrolysis of pure compounds was conducted and antioxidant activity of the plant was determined.

From the aerial parts of Astragalus armatus, a new acylated flavonol triglycoside, isorhamnetin-3-O-(5'"-p-hydroxybenzoyl)-β-apiofuranosyl-(1→2)[ α-rhamnopyranosyl-(1→6)]-β-galactopyranoside (1) which we named astrarmatuside, has been isolated and structurally elucidated together with seven known flavonol glycosides: tamarixetin-3-O-α-apiofuranosyl-(1→2) [α-rhamnopyranosyl-(1→6)]-β-galactopyranoside (2) (millettiaspecoside D), isorhamnetin-3-O-β-apiofuranosyl-(1?2)[a-rhamnopyranosyl-(1→6)]- β-galacto-pyranoside (3), kaempferol-3-O-α-rhamnopyranosyl-(1→2)[β-rhamnopyranosyl-(1→6)]-β-glucopyranoside (4), kaempferol-3-O-α-rhamnopyranosyl-(1→2)[α-rhamnopyranosyl-(1→6)]-β-galactopyranoside (mauritianin) (5), isorhamnetin-3-O-α-rhamnopyranosyl-(1→2)[α-rhamnopyranosyl-(1→6)]-β-galactopyranoside (6), kaempferol-3-O-α-rhamnopyranosyl-(1→6)]-β-glucopyranoside (nikotiflorin) (7) and isorhamnetin-3-O-α-rhamnopyranosyl-(1→6)]-β-glucopyranoside (narcissin) (8). The structures of the isolated compounds were established by means of 2D NMR experiments, HPLC-DADMS, HR-MS and UV spectral analyses. Pivotal role in the structure elucidation and in particular in the determination of sugar sequence, played HSQC-TOCSY and ROESY experiments whereas those of the known compounds (2-8) were established by spectral comparison with those published in the literature. [ABSTRACT FROM AUTHOR]

A new 2-alkylhydroquinone glucoside, 1-O-β-d-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl)benzene (1), in addition to nine known compounds were isolated from the aerial parts of Phagnalon saxatile (L.) Cass. (Asteraceae). Their structures were identified based on spectroscopic methods including 1D and 2D NMR, mass spectrometry (HR-ESI-MS), UV spectral analyses and by comparison with literature data. The cytotoxic activity of three isolated compounds (1-3) was evaluated against fibrosarcoma (HT1080), human lung cancer (A549) and breast cancer (MCF7) cell lines.