9,760 results on '"Berra, A."'
Search Results
2. International migration, refugees, and spread of tuberculosis in Brazil: Analysis of clusters, trends, and associated factors (2010-2021)
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Alves, Yan Mathias, Berra, Thais Zamboni, Tavares, Reginaldo Bazon Vaz, Popolin, Marcela Antunes Paschoal, da Costa, Fernanda Bruzadelli Paulino, de Jezus, Sonia Vivian, Ferezin, Letícia Perticarrara, Tartaro, Ariela Fehr, Serrano-Gallardo, Maria Del Pilar, Pinto, Ione Carvalho, Maciel, Ethel Leonor Noia, and Arcencio, Ricardo Alexandre
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- 2024
3. Star exponentials from propagators and path integrals
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Berra-Montiel, Jasel, Garcia-Compean, Hugo, and Molgado, Alberto
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Mathematical Physics ,Quantum Physics ,81S30, 46F10, 53D55, 81S40 - Abstract
In this paper we address the relation between the star exponentials emerging within the Deformation Quantization formalism and Feynman's path integrals associated with propagators in quantum dynamics. In order to obtain such a relation, we start by visualizing the quantum propagator as an integral transform of the star exponential by means of the symbol corresponding to the time evolution operator and, thus, we introduce Feynman's path integral representation of the propagator as a sum over all the classical histories. The star exponential thus constructed has the advantage that it does not depend on the convergence of formal series, as commonly understood within the context of Deformation Quantization. We include some basic examples to illustrate our findings, recovering standard results reported in the literature. Further, for an arbitrary finite dimensional system, we use the star exponential introduced here in order to find a particular representation of the star product which resembles the one encountered in the context of the quantum field theory for a Poisson sigma model., Comment: 18 pages, no figures
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- 2024
4. Sawyer estimates of mixed type for operators associated to a critical radius function
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Berra, Fabio, Pradolini, Gladis, and Quijano, Pablo
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Mathematics - Classical Analysis and ODEs ,42B20, 42B25, 35J10 - Abstract
We prove mixed inequalities for the Hardy-Littlewood maximal function $M^{\rho,\sigma}$, where $\rho$ is a critical radius function and $\sigma\geq 0$. We also exhibit and prove an extension of Cruz-Uribe, Martell and P\'erez extrapolation result in \cite{CruzUribe-Martell-Perez} to the setting of Muckenhoupt weights associated to a critical radius function $\rho$. This theorem allows us to give mixed inequalities for Schr\"odinger-Calder\'on-Zygmund operators, extending some previous estimates that we have already proved in \cite{BPQ}. Since we are dealing with unrelated weights, the proof involves a quite subtle argument related with the original ideas from Sawyer in \cite{Sawyer}., Comment: 23 pages
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- 2024
5. Endpoint estimates for higher order Gaussian Riesz transforms
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Berra, Fabio, Dalmasso, Estefanía, and Scotto, Roberto
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Mathematics - Classical Analysis and ODEs ,42B20, 42B30, 42B35 - Abstract
We will show that, contrary to the behavior of the higher order Riesz transforms studied so far on the atomic Hardy space $\mathcal{H}^1(\mathbb R^n, \gamma)$, associated with the Ornstein-Uhlenbeck operator with respect to the $n$-dimensional Gaussian measure $\gamma$, the new Gaussian Riesz transforms are bounded from $\mathcal{H}^1(\mathbb R^n, \gamma)$ to $L^1(\mathbb R^n, \gamma)$, for any order and dimension $n$. We will also prove that the classical Gaussian Riesz transforms of higher order are bounded from an adequate subspace of $\mathcal{H}^1(\mathbb R^n, \gamma)$ into $L^1(\mathbb R^n, \gamma)$, extending Bruno's result (J. Fourier Anal. Appl. 25, 4 (2019), 1609--1631) for the first order case., Comment: 15 pages
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- 2024
6. Impact of Vocabulary Teaching Approach in Turkish Curriculum on Turkish Textbooks and Use of Technology in Vocabulary Teaching
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Mete, Filiz, Alibasiç, Berra, and Köksal, Beyza
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Knowing a word means knowing its pronunciation, spelling, concept area, and meaning layers. Vocabulary is never an area that can be learned completely by individuals; rather it is a field that expands and deepens throughout life. Vocabulary teaching requires much more than just looking up words in a dictionary or using them in a sentence. Vocabulary is formed either by coincidence through indirect exposure to words or by deliberate and planned acquisition of certain words with vocabulary learning strategies. In this respect, the materials and lesson plans for teaching vocabulary should be prepared to enable the individual to comprehend words with multiple meanings and to use them effectively. Because the vocabulary of an individual will directly have an impact on effective use of four basic skills of the language (listening, reading, speaking, and writing). In this study, the approach of the Turkish curriculum and Turkish textbooks to vocabulary teaching is examined and the areas of utilisation of web 2.0 tools in vocabulary teaching are exemplified within the scope of technological development. This research is a qualitative study using the data which were collected through document analysis. Data collection sources are Turkish course curricula and secondary school Turkish textbooks. Results of the study show that, there is a conflict between the curriculum and the textbook in terms of vocabulary teaching; the vocabulary teaching activities are monotonous and are predominantly associated with the reading skill which is just one of the four basic language skills; Turkish textbooks lack addressing to related technological tools. Moreover, the planning of vocabulary teaching in the Turkish curriculum is not clear enough. In this context, the present study introduces various web 2.0 tools for the interest of curriculum developers, textbook authors, and Turkish teachers to effectively teach vocabulary.
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- 2023
7. Effects of MDMA-assisted therapy for PTSD on self-experience.
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van der Kolk, Bessel, Wang, Julie, Yehuda, Rachel, Bedrosian, Leah, Coker, Allison, Harrison, Charlotte, Mithoefer, Michael, Yazar-Klosinki, Berra, Emerson, Amy, and Doblin, Rick
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Humans ,N-Methyl-3 ,4-methylenedioxyamphetamine ,Stress Disorders ,Post-Traumatic ,Hallucinogens ,Anxiety ,Coping Skills - Abstract
INTRODUCTION: There is a resurgence of interest in the therapeutic potential of psychedelic substances such as 3,4-methylenedioxymethamphetamine (MDMA). Primary findings from our randomized, double-blind, placebo-controlled, multi-site Phase 3 clinical trial of participants with severe PTSD (NCT03537014) showed that MDMA-assisted therapy induced significant attenuation in the Clinician-Administered PTSD Scale for DSM-5 compared to Therapy with placebo. Deficits in emotional coping skills and altered self-capacities constitute major obstacles to successful completion of available treatments. The current analysis evaluated the differential effects of MDMA-assisted therapy and Therapy with placebo on 3 transdiagnostic outcome measures and explored the contribution of changes in self-experience to improvement in PTSD scores. METHODS: Participants were randomized to receive manualized therapy with either MDMA or placebo during 3 experimental sessions in combination with 3 preparation and 9 integration therapy visits. Symptoms were measured at baseline and 2 months after the last experimental session using the 20-item Toronto Alexithymia Scale (TAS-20), the 26-item Self Compassion Scale (SCS), and the 63-item Inventory of Altered Self-Capacities (IASC). RESULTS: 90 participants were randomized and dosed (MDMA-assisted therapy, n = 46; Therapy with placebo, n = 44); 84.4% (76/90) had histories of developmental trauma, and 87.8% (79/90) had suffered multiple traumas. MDMA-assisted therapy facilitated statistically significant greater improvement on the TAS-20, the SCS, and most IASC factors of interpersonal conflicts; idealization disillusionment; abandonment concerns; identity impairment; self-awareness; susceptibility to influence; affect dysregulation; affect instability; affect skill deficit; tension reduction activities; the only exception was identity diffusion. CONCLUSION: Compared with Therapy with placebo, MDMA-assisted therapy had significant positive effects on transdiagnostic mental processes of self-experience which are often associated with poor treatment outcome. This provides a possible window into understanding the psychological capacities facilitated by psychedelic agents that may result in significant improvements in PTSD symptomatology.
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- 2024
8. Corrigendum to “From A1A∞ to A1A∞: New Mixed Inequalities for Certain Maximal Operators”
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Berra, Fabio
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- 2024
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9. Weighted mixed endpoint estimates of Fefferman-Stein type for commutators of singular integral operators
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Berra, Fabio, Pradolini, Gladis, and Recchi, Jorgelina
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Mathematics - Classical Analysis and ODEs ,42B20, 42B25 - Abstract
We deal with mixed weak estimates of Fefferman-Stein type for higher order commutators of Calder\'on-Zygmund operators with BMO symbol. The results obtained are Fefferman-Stein inequalities that include the estimates proved in \cite{BCP22(JMS)} for the case of singular integral operators, as well as the classical weak endpoint estimate for commutators given in \cite{PP01}. We also consider commutators of operators involving less regular kernels satisfying an $L^{\Phi}$--H\"ormander condition. Particularly, the obtained results contain some previous estimates proved in \cite{BCP22(JMS)} and \cite{Lorente-Martell-Perez-Riveros}., Comment: 26 pages
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- 2023
10. Smoothness properties related to several commutators of fractional operators for values of $\boldsymbol{p}$ beyond the extreme in the multilinear setting
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Berra, Fabio and Ramos, Wilfredo
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Mathematics - Classical Analysis and ODEs ,26A33, 26D10 - Abstract
We prove continuity properties of higher order commutators of fractional operators on the multilinear setting, between a product of weighted Lebesgue spaces into certain weighted Lipschitz spaces. The considered operators include the multilinear fractional integral function and the main results extend previous estimates known for the unweighted case, as well as those established on the linear case. We give a complete study showing the main properties of the related multilinear weights and the optimal region described by the parameters where we can find nontrivial examples, including the restricted case of the one-weight theory. We also exhibit examples of such weights on the whole region., Comment: 24 pages. arXiv admin note: text overlap with arXiv:2209.14103
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- 2023
11. Derivation and external validation of predictive models for invasive mechanical ventilation in intensive care unit patients with COVID-19
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Gabriel Maia, Camila Marinelli Martins, Victoria Marques, Samantha Christovam, Isabela Prado, Bruno Moraes, Emanuele Rezoagli, Giuseppe Foti, Vanessa Zambelli, Maurizio Cereda, Lorenzo Berra, Patricia Rieken Macedo Rocco, Mônica Rodrigues Cruz, Cynthia dos Santos Samary, Fernando Silva Guimarães, and Pedro Leme Silva
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COVID-19 ,SOFA score ,SpO2 ,Multiple logistic regression ,Invasive mechanical ventilation ,External validation ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background This study aimed to develop prognostic models for predicting the need for invasive mechanical ventilation (IMV) in intensive care unit (ICU) patients with COVID-19 and compare their performance with the Respiratory rate-OXygenation (ROX) index. Methods A retrospective cohort study was conducted using data collected between March 2020 and August 2021 at three hospitals in Rio de Janeiro, Brazil. ICU patients aged 18 years and older with a diagnosis of COVID-19 were screened. The exclusion criteria were patients who received IMV within the first 24 h of ICU admission, pregnancy, clinical decision for minimal end-of-life care and missing primary outcome data. Clinical and laboratory variables were collected. Multiple logistic regression analysis was performed to select predictor variables. Models were based on the lowest Akaike Information Criteria (AIC) and lowest AIC with significant p values. Assessment of predictive performance was done for discrimination and calibration. Areas under the curves (AUC)s were compared using DeLong’s algorithm. Models were validated externally using an international database. Results Of 656 patients screened, 346 patients were included; 155 required IMV (44.8%), 191 did not (55.2%), and 207 patients were male (59.8%). According to the lowest AIC, arterial hypertension, diabetes mellitus, obesity, Sequential Organ Failure Assessment (SOFA) score, heart rate, respiratory rate, peripheral oxygen saturation (SpO2), temperature, respiratory effort signals, and leukocytes were identified as predictors of IMV at hospital admission. According to AIC with significant p values, SOFA score, SpO2, and respiratory effort signals were the best predictors of IMV; odds ratios (95% confidence interval): 1.46 (1.07–2.05), 0.81 (0.72–0.90), 9.13 (3.29–28.67), respectively. The ROX index at admission was lower in the IMV group than in the non-IMV group (7.3 [5.2–9.8] versus 9.6 [6.8–12.9], p
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- 2024
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12. A comparative analysis of classical and machine learning methods for forecasting TB/HIV co-infection
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André Abade, Lucas Faria Porto, Alessandro Rolim Scholze, Daniely Kuntath, Nathan da Silva Barros, Thaís Zamboni Berra, Antonio Carlos Vieira Ramos, Ricardo Alexandre Arcêncio, and Josilene Dália Alves
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Medicine ,Science - Abstract
Abstract TB/HIV coinfection poses a complex public health challenge. Accurate forecasting of future trends is essential for efficient resource allocation and intervention strategy development. This study compares classical statistical and machine learning models to predict TB/HIV coinfection cases stratified by gender and the general populations. We analyzed time series data using exponential smoothing and ARIMA to establish the baseline trend and seasonality. Subsequently, machine learning models (SVR, XGBoost, LSTM, CNN, GRU, CNN-GRU, and CNN-LSTM) were employed to capture the complex dynamics and inherent non-linearities of TB/HIV coinfection data. Performance metrics (MSE, MAE, sMAPE) and the Diebold-Mariano test were used to evaluate the model performance. Results revealed that Deep Learning models, particularly Bidirectional LSTM and CNN-LSTM, significantly outperformed classical methods. This demonstrates the effectiveness of Deep Learning for modeling TB/HIV coinfection time series and generating more accurate forecasts.
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- 2024
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13. The COVID-19 pandemic in Brazil: space-time approach of cases, deaths, and vaccination coverage (February 2020 – April 2024)
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Thaís Zamboni Berra, Yan Mathias Alves, Marcela Antunes Paschoal Popolin, Fernanda Bruzadelli Paulino da Costa, Reginaldo Bazon Vaz Tavares, Ariela Feh Tártaro, Heriederson Sávio Dias Moura, Letícia Perticarrara Ferezin, Monica Chiodi Toscano de Campos, Natacha Martins Ribeiro, Titilade Kehinde Ayandeyi Teibo, Rander Junior Rosa, and Ricardo Alexandre Arcêncio
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COVID-19 ,Time Series Analysis ,Spatial analysis ,Real World evidence ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Objective To assess the evolution of the COVID-19 pandemic in Brazil and its macro-regions, considering disease incidence and mortality rates, as well as identifying territories with still rising disease indices and evaluating vaccine coverage and population adherence to COVID-19 immunization. Methods An ecological study conducted in Brazil with COVID-19 cases and deaths reported between February 2020 and April 2024, obtained through the Coronavirus Panel. Historical series were constructed from incidence and mortality rates to assess the pandemic’s evolution, and temporal trends were estimated using the Seasonal Trend Decomposition using Loess (STL) method. The Spatial Variation in Temporal Trends (SVTT) technique was employed to identify clusters with significant variations in temporal trends. Vaccination was analyzed considering the percentage of vaccinated and unvaccinated population in each municipality of the country. Results Brazil recorded a total of 38,795,966 cases and 712,038 deaths from COVID-19 during the study period. Incidence and mortality rates showed three waves of the disease, with a fourth wave of smaller amplitude. Four clusters with significant case growth and two with increased deaths were identified. Vaccine coverage varied among municipalities, with some regions showing low vaccination rates and others with high immunization adherence. Conclusion The study provided a comprehensive overview of coronavirus behavior in Brazil, and its results highlight the ongoing importance of vaccination and the need to direct efforts and resources to areas of higher risk.
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- 2024
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14. Evaluation of oxidative stress and inflammation in patients with polycystic ovary syndrome
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Berra Sen, Senem Gonultas, Ceren Albayrak, Sevval Temur, Ilgar Acar, Beyza Nur Ozkan, Havva Sevde Islek, Muserref Banu Yilmaz, Ebru Kale, and Eray Metin Guler
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inflammation ,oxidative stress ,polycystic ovary syndrome ,reactive oxygen species ,disulfide ,Gynecology and obstetrics ,RG1-991 - Abstract
Objective Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder characterized by hyperandrogenism, hyperinsulinemia, and insulin resistance. The prevalence of PCOS is increasing worldwide. Although the etiology of this disease is currently unknown, it is thought to be closely related to inflammation and oxidative stress. Our study aimed to compare patients have PCOS to healthy volunteers and assess the changes in oxidative stress and inflammatory parameters in these patients. Methods Thirty patients between the ages of 18-45 diagnosed with PCOS and 30 healthy volunteers with the same demographic characteristics were included in this study. Clinical parameters were measured using immunoassays. Oxidative stress biomarkers, total oxidant (TOS), total antioxidant (TAS), total thiol (TT), and native thiol (NT) levels were measured using photometric methods according to Erel’s method. The dynamic disulfide level (DIS) and oxidative stress index (OSI) were calculated using mathematical equations. Among the inflammatory parameters, values for interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were measured photometrically using commercially purchased kits. Results Moreover, TT and NT levels were lower in patients with PCOS compared to those in the healthy group statistically significantly (P
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- 2024
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15. Spatial distribution and temporal trend of childhood tuberculosis in Brazil
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da Costa, Fernanda Bruzadelli Paulino, Ramos, Antonio Carlos Vieira, Berra, Thais Zamboni, Alves, Yan Mathias, dos Santos Silva, Ruan Victor, de Almeida Crispim, Juliane, dos Santos, Marcio Souza, Nanque, Adelia Roberto, Teibo, Titilade Kehinde Ayandeyi, and Arcencio, Ricardo Alexandre
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- 2023
16. Synchronization of quantum communication over an optical classical communication channel
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Berra, Federico, Agnesi, Costantino, Stanco, Andrea, Avesani, Marco, Kuklewski, Michal, Matter, Daniel, Villoresi, Paolo, and Vallone, Giuseppe
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Quantum Physics - Abstract
Precise synchronization between transmitter and receiver is crucial for quantum communication protocols, such as Quantum Key Distribution (QKD), to efficiently correlate the transmitted and received signals and increase the signal-to-noise ratio. In this work, we introduce a synchronization technique that exploits a co-propagating classical optical communication link and test its performance in a free-space QKD system. Previously, existing techniques required additional laser beams or relied on the capability of retrieving the synchronization from the quantum signal itself, though this is not applicable in high channel loss scenarios. On the contrary, our method exploits classical and quantum signals locked to the same master clock, allowing the receiver to synchronize both the classical and quantum communication links by performing a clock-data-recovery routine on the classical signal. In this way, by exploiting the same classical communication already required for post-processing and key generation, no additional hardware is required, and the synchronization can be reconstructed from a high-power signal. Our approach is suitable for both satellite and fiber infrastructures, where a classical and quantum channel can be transmitted through the same link., Comment: 6 pages, 5 figures
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- 2023
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17. MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
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Mitchell, Jennifer M, Ot’alora G., Marcela, van der Kolk, Bessel, Shannon, Scott, Bogenschutz, Michael, Gelfand, Yevgeniy, Paleos, Casey, Nicholas, Christopher R, Quevedo, Sylvestre, Balliett, Brooke, Hamilton, Scott, Mithoefer, Michael, Kleiman, Sarah, Parker-Guilbert, Kelly, Tzarfaty, Keren, Harrison, Charlotte, de Boer, Alberdina, Doblin, Rick, and Yazar-Klosinski, Berra
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Biomedical and Clinical Sciences ,Clinical Sciences ,Brain Disorders ,Behavioral and Social Science ,Post-Traumatic Stress Disorder (PTSD) ,Clinical Research ,Mental Health ,Clinical Trials and Supportive Activities ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,MAPP2 Study Collaborator Group ,Medical and Health Sciences ,Immunology ,Biomedical and clinical sciences ,Health sciences - Abstract
This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy and safety of 3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus placebo with identical therapy in participants with moderate to severe post-traumatic stress disorder (PTSD). Changes in Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) total severity score (primary endpoint) and Sheehan Disability Scale (SDS) functional impairment score (key secondary endpoint) were assessed by blinded independent assessors. Participants were randomized to MDMA-AT (n = 53) or placebo with therapy (n = 51). Overall, 26.9% (28/104) of participants had moderate PTSD, and 73.1% (76/104) of participants had severe PTSD. Participants were ethnoracially diverse: 28 of 104 (26.9%) identified as Hispanic/Latino, and 35 of 104 (33.7%) identified as other than White. Least squares (LS) mean change in CAPS-5 score (95% confidence interval (CI)) was -23.7 (-26.94, -20.44) for MDMA-AT versus -14.8 (-18.28, -11.28) for placebo with therapy (P
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- 2023
18. Mining in Carbonate Rocks in the Metropolitan Region of Curitiba, PR: Challenges for the Preservation of Karst and Speleological Heritage /A mineracao em Rochas Carbonaticas na Regiao Metropolitana de Curitiba- PR: Desafios para a Preservacao do Patrimonio Carstico e Espeleolcgico
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do Nascimento, Edenilson Roberto, Sessegolo, Gisele Cristina, Berra, Elias Fernando, da Silveira, Claudinei Taborda, and Sampaio, Tony Vinicius Moreira
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- 2024
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19. Design of a Flexible Robot Arm for Safe Aerial Physical Interaction.
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Julien Mellet, Andrea Berra, Achilleas Santi Seisa, Viswa Narayanan Sankaranarayanan, Udayanga G. W. K. N. Gamage, Miguel Angel Trujillo Soto, Guillermo Heredia, George Nikolakopoulos, Vincenzo Lippiello, and Fabio Ruggiero
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- 2024
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20. Obesity and Mechanical Ventilation
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Berra, Lorenzo, Grassi, Luigi G., Rounds, Sharon I. S., Series Editor, Dixon, Anne E., Series Editor, Schnapp, Lynn M., Series Editor, and Forno, Erick, editor
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- 2024
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21. Derivation and external validation of predictive models for invasive mechanical ventilation in intensive care unit patients with COVID-19
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Maia, Gabriel, Martins, Camila Marinelli, Marques, Victoria, Christovam, Samantha, Prado, Isabela, Moraes, Bruno, Rezoagli, Emanuele, Foti, Giuseppe, Zambelli, Vanessa, Cereda, Maurizio, Berra, Lorenzo, Rocco, Patricia Rieken Macedo, Cruz, Mônica Rodrigues, Samary, Cynthia dos Santos, Guimarães, Fernando Silva, and Silva, Pedro Leme
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- 2024
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22. A comparative analysis of classical and machine learning methods for forecasting TB/HIV co-infection
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Abade, André, Porto, Lucas Faria, Scholze, Alessandro Rolim, Kuntath, Daniely, Barros, Nathan da Silva, Berra, Thaís Zamboni, Ramos, Antonio Carlos Vieira, Arcêncio, Ricardo Alexandre, and Alves, Josilene Dália
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- 2024
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23. Food insecurity, income loss, healthcare access, and other exacerbated social inequalities among people experiencing homelessness during the COVID-19 pandemic in Brazil (2021–2023)
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Moura, Heriederson Sávio Dias, Canatto, Mayla Cristina Dinardi, Berra, Thaís Zamboni, Silva, Ruan Víctor dos Santos, Rosa, Rander Junior, Campos, Mônica Chiodi Toscano de, Costa, Fernanda Bruzadelli Paulino da, Ribeiro, Natacha Martins, Teibo, Titilade Kehinde Ayandeyi, Araújo, Juliana Soares Tenório de, Tártaro, Ariela Fehr, Alves, Yan Mathias, Souza, Rosa Maria Pinheiro, Uchoa, Severina Alice da Costa, Ferezin, Letícia Perticarrara, and Arcêncio, Ricardo Alexandre
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- 2024
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24. Implementation research: a protocol for two three-arm pragmatic randomised controlled trials on continuous glucose monitoring devices in people with type 1 diabetes in South Africa and Kenya
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Marbán-Castro, Elena, Muhwava, Lorrein, Kamau, Yvonne, Safary, Elvis, Rheeder, Paul, Karsas, Maria, Kemp, Tanja, Freitas, Johanè, Carrihill, Michelle, Dave, Joel, Katambo, Daniel, Kimetto, Joan, Allie, Razana, Ndungu, Joseph, Sigwebela, Ntombi, Akach, Dorcas, Girdwood, Sarah, Erkosar, Berra, Nichols, Brooke E., Haldane, Cathy, Vetter, Beatrice, and Shilton, Sonjelle
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- 2024
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25. Clinical accuracy of instrument-based SARS-CoV-2 antigen diagnostic tests: a systematic review and meta-analysis
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Manten, Katharina, Katzenschlager, Stephan, Brümmer, Lukas E., Schmitz, Stephani, Gaeddert, Mary, Erdmann, Christian, Grilli, Maurizio, Pollock, Nira R., Macé, Aurélien, Erkosar, Berra, Carmona, Sergio, Ongarello, Stefano, Johnson, Cheryl C., Sacks, Jilian A., Faehling, Verena, Bornemann, Linus, Weigand, Markus A., Denkinger, Claudia M., and Yerlikaya, Seda
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- 2024
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26. Unsuccessful tuberculosis treatment outcomes across Brazil's geographical landscape before and during the COVID-19 pandemic: are we truly advancing toward the sustainable development/end TB goal?
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Tavares, Reginaldo Bazon Vaz, Berra, Thaís Zamboni, Alves, Yan Mathias, Popolin, Marcela Antunes Paschoal, Ramos, Antônio Carlos Vieira, Tártaro, Ariela Fehr, de Souza, Clara Ferreira, and Arcêncio, Ricardo Alexandre
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- 2024
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27. Implementing a pilot study of COVID-19 self-testing in high-risk populations and remote locations: results and lessons learnt
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Marbán-Castro, Elena, Getia, Vladimer, Alkhazashvili, Maia, Japaridze, Maia, Jikia, Ia, Erkosar, Berra, Del Rey-Puech, Paula, Martínez-Pérez, Guillermo Z., Imnadze, Paata, Gamkrelidze, Amiran, Denisiuk, Olga, Reipold, Elena Ivanova, and Shilton, Sonjelle
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- 2024
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28. In vitro antioxidant activities of copper mixed oxide (CuO/Cu2O) nanoparticles produced from the leaves of Phoenix dactylifera L
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Djamila, Berra, Eddine, Laouini Salah, Abderrhmane, Bouafia, Nassiba, Allag, and Barhoum, Ahmed
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- 2024
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29. Detection of copper in boiled water samples from traditional coffee pots by applying deep eutectic solvent-assisted reduced graphene oxide-coated magnetic nanocomposite-based microextraction strategy
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Kasa, Nursu Aylin, Zeytinci, Nagehan Kübra, Aydin, Berra Nur, and Bakirdere, Sezgin
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- 2024
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30. Photocatalytic activity of iron oxide nanoparticles synthesized by different plant extracts for the degradation of diazo dyes Evans blue and Congo red
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Meneceur, Souhaila, Hemmami, Hadia, Bouafia, Abderrhmane, Laouini, Salah Eddine, Tedjani, Mohammed Laid, Berra, Djamila, and Mahboub, Mohammed Sadok
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- 2024
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31. Gender differences in trajectories of health-related quality of life from childhood to adolescence in a 7-year follow-up study in a urban socially disadvantaged sample from Argentina
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Berra, Silvina, Bernaschini, María Eugenia, Mamondi, Verónica, and Rajmil, Luis
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- 2024
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32. Trend and spatial distribution of drug-resistant tuberculosis in liberty-deprived populations in the state of Parana, Brazil
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Souza dos Santos, Marcio, Berra, Thais Zamboni, Scholze, Alessandro Rolim, Delpino, Felipe Mendes, Ramos, Antonio Carlos Vieira, Alves, Yan Mathias, Costa, Fernanda Bruzadelli Paulino da, de Almeida Crispim, Juliane, Giacomet, Clovis Luciano, Moura, Heriederson Savio Dias, Teibo, Titilade Kehinde Ayandeyi, Peres, Ana Carolina Silva, Freitas, Giselle Lima de, Pieri, Flavia Meneguetti, and Arcencio, Ricardo Alexandre
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- 2022
33. Unsupervised Active Visual Search with Monte Carlo planning under Uncertain Detections
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Taioli, Francesco, Giuliari, Francesco, Wang, Yiming, Berra, Riccardo, Castellini, Alberto, Del Bue, Alessio, Farinelli, Alessandro, Cristani, Marco, and Setti, Francesco
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Computer Science - Robotics - Abstract
We propose a solution for Active Visual Search of objects in an environment, whose 2D floor map is the only known information. Our solution has three key features that make it more plausible and robust to detector failures compared to state-of-the-art methods: (i) it is unsupervised as it does not need any training sessions. (ii) During the exploration, a probability distribution on the 2D floor map is updated according to an intuitive mechanism, while an improved belief update increases the effectiveness of the agent's exploration. (iii) We incorporate the awareness that an object detector may fail into the aforementioned probability modelling by exploiting the success statistics of a specific detector. Our solution is dubbed POMP-BE-PD (Pomcp-based Online Motion Planning with Belief by Exploration and Probabilistic Detection). It uses the current pose of an agent and an RGB-D observation to learn an optimal search policy, exploiting a POMDP solved by a Monte-Carlo planning approach. On the Active Vision Database benchmark, we increase the average success rate over all the environments by a significant 35% while decreasing the average path length by 4% with respect to competing methods. Thus, our results are state-of-the-art, even without using any training procedure., Comment: 12 pages,8 figures. Submitted for review at IEEE Transactions on Pattern Analysis and Machine Intelligence. arXiv admin note: text overlap with arXiv:2009.08140
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- 2023
34. Modular source for near-infrared quantum communication
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Berra, Federico, Agnesi, Costantino, Stanco, Andrea, Avesani, Marco, Cocchi, Sebastiano, Villoresi, Paolo, and Vallone, Giuseppe
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Quantum Physics - Abstract
We present a source of states for Quantum Key Distribution (QKD) based on a modular design exploiting the iPOGNAC, a stable, low-error, and calibration-free polarization modulation scheme, for both intensity and polarization encoding. This source is immune to the security vulnerabilities of other state sources such as side channels and some quantum hacking attacks. Furthermore, our intensity modulation scheme allows full tunability of the intensity ratio between the decoy and signal states, and mitigates patterning effects. The source was implemented and tested at the near-infrared optical band around 800 nm, of particular interest for satellite-based QKD. Remarkably, the modularity of the source simplifies its development, testing, and qualification, especially for space missions. For these reasons, our work paves the way for the development of the second generation of QKD satellites that can guarantee excellent performances at higher security levels., Comment: 7 pages, 6 figures
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- 2023
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35. Implementation research: a protocol for two three-arm pragmatic randomised controlled trials on continuous glucose monitoring devices in people with type 1 diabetes in South Africa and Kenya
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Elena Marbán-Castro, Lorrein Muhwava, Yvonne Kamau, Elvis Safary, Paul Rheeder, Maria Karsas, Tanja Kemp, Johanè Freitas, Michelle Carrihill, Joel Dave, Daniel Katambo, Joan Kimetto, Razana Allie, Kenya ACCEDE study group, South Africa ACCEDE study group, Joseph Ndungu, Ntombi Sigwebela, Dorcas Akach, Sarah Girdwood, Berra Erkosar, Brooke E. Nichols, Cathy Haldane, Beatrice Vetter, and Sonjelle Shilton
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(3–10): glucose monitoring ,CGM ,Continuous glucose monitoring ,Protocol ,Standard of care ,Type 1 diabetes ,Medicine (General) ,R5-920 - Abstract
Abstract Background Self-monitoring of glucose is an essential component of type 1 diabetes (T1D) management. In recent years, continuous glucose monitoring (CGM) has provided an alternative to daily fingerstick testing for the optimisation of insulin dosing and general glucose management in people with T1D. While studies have been conducted to evaluate the impact of CGM on clinical outcomes in the US, Europe and Australia, there are limited data available for low- and middle-income countries (LMICs) and further empirical evidence is needed to inform policy decision around their use in these countries. Methods This trial was designed as a pragmatic, parallel-group, open-label, multicentre, three-arm, randomised (1:1:1) controlled trial of continuous or periodic CGM device use versus standard of care in people with T1D in South Africa and Kenya. The primary objective of this trial will be to assess the impact of continuous or periodic CGM device use on glycaemic control as measured by change from baseline glycosylated haemoglobin (HbA1c). Additional assessments will include clinical outcomes (glucose variation, time in/below/above range), safety (adverse events, hospitalisations), quality of life (EQ-5D, T1D distress score, Glucose Monitoring Satisfaction Survey for T1D), and health economic measures (incremental cost-effectiveness ratios, quality adjusted life years). Discussion This trial aims to address the substantial evidence gap on the impact of CGM device use on clinical outcomes in LMICs, specifically South Africa and Kenya. The trial results will provide evidence to inform policy and treatment decisions in these countries. Trial registration NCT05944731 (Kenya), July 6, 2023; NCT05944718 (South Africa), July 13, 2023.
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- 2024
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36. Clinical accuracy of instrument-based SARS-CoV-2 antigen diagnostic tests: a systematic review and meta-analysis
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Katharina Manten, Stephan Katzenschlager, Lukas E. Brümmer, Stephani Schmitz, Mary Gaeddert, Christian Erdmann, Maurizio Grilli, Nira R. Pollock, Aurélien Macé, Berra Erkosar, Sergio Carmona, Stefano Ongarello, Cheryl C. Johnson, Jilian A. Sacks, Verena Faehling, Linus Bornemann, Markus A. Weigand, Claudia M. Denkinger, and Seda Yerlikaya
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COVID-19 ,Instrument-based ,Antigen test ,Systematic review ,Meta-analysis ,SARS-CoV-2 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background During the COVID-19 pandemic, antigen diagnostic tests were frequently used for screening, triage, and diagnosis. Novel instrument-based antigen tests (iAg tests) hold the promise of outperforming their instrument-free, visually-read counterparts. Here, we provide a systematic review and meta-analysis of the SARS-CoV-2 iAg tests’ clinical accuracy. Methods We systematically searched MEDLINE (via PubMed), Web of Science, medRxiv, and bioRxiv for articles published before November 7th, 2022, evaluating the accuracy of iAg tests for SARS-CoV-2 detection. We performed a random effects meta-analysis to estimate sensitivity and specificity and used the QUADAS-2 tool to assess study quality and risk of bias. Sub-group analysis was conducted based on Ct value range, IFU-conformity, age, symptom presence and duration, and the variant of concern. Results We screened the titles and abstracts of 20,431 articles and included 114 publications that fulfilled the inclusion criteria. Additionally, we incorporated three articles sourced from the FIND website, totaling 117 studies encompassing 95,181 individuals, which evaluated the clinical accuracy of 24 commercial COVID-19 iAg tests. The studies varied in risk of bias but showed high applicability. Of 24 iAg tests from 99 studies assessed in the meta-analysis, the pooled sensitivity and specificity compared to molecular testing of a paired NP swab sample were 76.7% (95% CI 73.5 to 79.7) and 98.4% (95% CI 98.0 to 98.7), respectively. Higher sensitivity was noted in individuals with high viral load (99.6% [95% CI 96.8 to 100] at Ct-level ≤ 20) and within the first week of symptom onset (84.6% [95% CI 78.2 to 89.3]), but did not differ between tests conducted as per manufacturer’s instructions and those conducted differently, or between point-of-care and lab-based testing. Conclusion Overall, iAg tests have a high pooled specificity but a moderate pooled sensitivity, according to our analysis. The pooled sensitivity increases with lower Ct-values (a proxy for viral load), or within the first week of symptom onset, enabling reliable identification of most COVID-19 cases and highlighting the importance of context in test selection. The study underscores the need for careful evaluation considering performance variations and operational features of iAg tests.
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- 2024
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37. Impact of COVID-19 on tuberculosis indicators in Brazil: A time series and spatial analysis study
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Berra, Thais Zamboni, Vieira Ramos, Antonio Carlos, Alves, Yan Mathias, Tavares, Reginaldo Bazon Vaz, Tartaro, Ariela Fehr, Nascimento, Murilo Cesar do, Moura, Heriederson Savio Dias, Delpino, Felipe Mendes, Soares, Debora de Almeida, Silva, Ruan Victor dos Santos, Gomes, Dulce, Monroe, Aline Aparecida, and Arcencio, Ricardo Alexandre
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- 2022
38. Retraction Note: MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials
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Mithoefer, Michael C., Feduccia, Allison A., Jerome, Lisa, Mithoefer, Anne, Wagner, Mark, Walsh, Zach, Hamilton, Scott, Yazar-Klosinski, Berra, Emerson, Amy, and Doblin, Rick
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- 2024
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39. Retraction Note: Long-term follow-up outcomes of MDMA-assisted psychotherapy for treatment of PTSD: a longitudinal pooled analysis of six phase 2 trials
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Jerome, Lisa, Feduccia, Allison A., Wang, Julie B., Hamilton, Scott, Yazar-Klosinski, Berra, Emerson, Amy, Mithoefer, Michael C., and Doblin, Rick
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- 2024
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40. A fast and convergent combined Newton and gradient descent method for computing steady states of chemical reaction networks
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Berra, Silvia, La Torraca, Alessandro, Benvenuto, Federico, and Sommariva, Sara
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Mathematics - Numerical Analysis ,65L05 (Primary) 65K10 (Secondary) - Abstract
In this work we present a fast, globally convergent, iterative algorithm for computing the asymptotically stable states of nonlinear large--scale systems of quadratic autonomous Ordinary Differential Equations (ODEs) modeling, e.g., the dynamic of complex chemical reaction networks. Towards this aim, we reformulate the problem as a box--constrained optimization problem where the roots of a set of nonlinear equations need to be determined. Then, we propose to use a projected Newton's approach combined with a gradient descent algorithm so that every limit point of the sequence generated by the overall algorithm is a stationary point. More importantly, we suggest replacing the standard orthogonal projector with a novel operator that ensures the final solution to satisfy the box constraints while lowering the probability that the intermediate points reached at each iteration belong to the boundary of the box where the Jacobian of the objective function may be singular. The effectiveness of the proposed approach is shown in a practical scenario concerning a chemical reaction network modeling the signaling network of colorectal cancer cells. Specifically, in this scenario the proposed algorithm is proven to be faster and more accurate than a classical dynamical approach where the asymptotically stable states are computed as the limit points of the flux of the Cauchy problem associated with the ODEs system., Comment: 22 pages, 5 figures, 1 table
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- 2022
41. Corrgiendum to 'From $A_1$ to $A_\infty$: new mixed inequalities for certain maximal operators'
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Berra, Fabio
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Mathematics - Classical Analysis and ODEs - Abstract
We devote this note to correct an estimate concerning mixed inequalities for the generalized maximal function $M_\Phi$, when certain properties of the associated Young function $\Phi$ are assumed. Although the obtained estimates turn out to be slightly different, they are good extensions of mixed inequalities for the classical Hardy-Littlewood maximal functions $M_r$, with $r\geq 1$. They also allow us to obtain mixed estimates for the generalized fractional maximal operator $M_{\gamma,\Phi}$, when $0<\gamma
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- 2022
42. Impact of Hemoglobin Levels on Composite Cardiac Arrest or Stroke Outcome in Patients With Respiratory Failure Due to COVID-19
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Shi Nan Feng, BSPH, Thu-Lan Kelly, PhD, John F. Fraser, MD, PhD, Gianluigi Li Bassi, MD, PhD, Jacky Suen, PhD, Akram Zaaqoq, MD, MPH, Matthew J. Griffee, MD, Rakesh C. Arora, MD, Nicole White, PhD, Glenn Whitman, MD, Chiara Robba, MD, PhD, Denise Battaglini, MD, PhD, Sung-Min Cho, DO, MHS, on behalf of COVID-19 Critical Care Consortium (CCCC), Robert Bartlett, John F. Fraser, Gianluigi Li Bassi, Jacky Y. Suen, Heidi J. Dalton, John Laffey, Daniel Brodie, Eddy Fan, Antoni Torres, Davide Chiumello, Alyaa Elhazm, Carol Hodgson, Shingo Ichiba, Carlos Luna, Srinivas Murthy, Alistair Nichol, Pauline Yeung Ng, Mark Ogino, Aidan Burrell, Antonio Pesenti, Tala Al-Dabbous, Huda Alfoudri, Mohammed Shamsah, Subbarao Elapavaluru, Ashley Berg, Christina Horn, Yunis Mayasi, Stephan Schroll, Dan Meyer, Jorge Velazco, Ludmyla Ploskanych, Wanda Fikes, Rohini Bagewadi, Marvin Dao, Haley White, Alondra Berrios Laviena, Ashley Ehlers Maysoon, Shalabi-McGuire, Trent Witt, Lorenzo Grazioli, Luca Lorini, E. Wilson Grandin, Jose Nunez, Tiago Reyes, Diarmuid O’Briain, Stephanie Hunter, Mahesh Ramanan, Julia Affleck, Hemanth Hurkadli Veerendra, Sumeet Rai, Josie Russell-Brown, Mary Nourse, Mark Joseph, Brook Mitchell, Martha Tenzer, Ryuzo Abe, Hwa Jin Cho, In Seok Jeong, Nadeem Rahman, Vivek Kakar, Andres Oswaldo Razo Vazquez, Nicolas Brozzi, Omar Mehkri, Sudhir Krishnan Abhijit, Duggal Stuart Houltham, Jerónimo Graf, Roderigo Diaz, Roderigo Orrego, Camila Delgado, Joyce González, Maria Soledad Sanchez, Michael Piagnerelli, Josefa Valenzuela Sarrazin, A/Prof. Gustavo Zabert, Lucio Espinosa, Paulo Delgado, Victoria Delgado, Diego Fernando, Bautista Rincón, Angela Maria Marulanda Yanten, Melissa Bustamante Duque, Alyaa Elhazmi, Abdullah Al-Hudaib, Maria Callahan, M. Azhari Taufik, Elizabeth Yasmin Wardoyo, Margaretha Gunawan, Nurindah S Trisnaningrum, Vera Irawany, Muhammad Rayhan, Mauro Panigada, Alberto Zanella, Giacomo Grasselli, Sebastiano Colombo, Chiara Martinet, Gaetano Florio, Massimo Antonelli, Simone Carelli, Domenico L. Grieco, Motohiro Asaki, Kota Hoshino, Leonardo Salazar, Mary Alejandra Mendoza Monsalve, Bairbre McNicholas, David Cosgrave, Joseph McCaffrey, Allison Bone, Yusuff Hakeem, James Winearls, Mandy Tallott, David Thomson, Christel Arnold-Day, Jerome Cupido, Zainap Fanie, Malcom Miller, Lisa Seymore, Dawid van Straaten, Ali Ait Hssain, Jeffrey Aliudin, Al-Reem Alqahtani, Khoulod Mohamed, Ahmed Mohamed, Darwin Tan, Joy Villanueva, Ahmed Zaqout, Ethan Kurtzman, Arben Ademi, Ana Dobrita, Khadija El Aoudi, Juliet Segura, Gezy Giwangkancana, Shinichiro Ohshimo, Javier Osatnik, Anne Joosten, Minlan Yang, Ana Motos, Francisco Arancibia, Virginie Williams, Alexandre Noel, Nestor Luque, Marina Fantini, Ruth Noemi Jorge García, Enrique Chicote Alvarez, Anna Greti, Adrian Ceccato, Angel Sanchez, Ana Loza Vazquez, Ferran Roche-Campo, Diego Franch-Llasat, Divina Tuazon, Marcelo Amato, Luciana Cassimiro, Flavio Pola, Francis Ribeiro, Guilherme Fonseca, Heidi Dalton, Mehul Desai, Erik Osborn Hala Deeb, Antonio Arcadipane, Gennaro Martucci, Giovanna Panarello, Chiara Vitiello, Claudia Bianco, Giovanna Occhipinti, Matteo Rossetti, Raffaele Cuffaro, Sung-Min Cho, Glenn Whitman, Hiroaki Shimizu, Naoki Moriyama, Jae-Burm Kim, Nobuya Kitamura, Johannes Gebauer, Toshiki Yokoyama, Abdulrahman Al-Fares, Sarah Buabbas, Esam Alamad, Fatma Alawadhi, Kalthoum Alawadi, Hiro Tanaka, Satoru Hashimoto, Masaki Yamazaki, Tak-Hyuck Oh, Mark Epler, Cathleen Forney, Louise Kruse, Jared Feister, Joelle Williamson, Katherine Grobengieser, Eric Gnall, Sasha Golden, Mara Caroline, Timothy Shapiro, Colleen Karaj, Lisa Thome, Lynn Sher, Mark Vanderland, Mary Welch, Sherry McDermott, Matthew Brain, Sarah Mineall, Dai Kimura, Luca Brazzi, Gabriele Sales, Giorgia Montrucchio, Tawnya Ogston, Dave Nagpal, Karlee Fischer, Roberto Lorusso, Rajavardhan Rangappa, Sujin Rai, Argin Appu, Mariano Esperatti, Nora Angélica Fuentes, Maria Eugenia Gonzalez, Edmund G. Carton, Ayan Sen, Amanda Palacios, Deborah Rainey, Gordan Samoukoviv, Josie Campisi, Lucia Durham, Emily Neumann, Cassandra Seefeldt, Octavio Falcucci, Amanda Emmrich, Jennifer Guy, Carling Johns, Kelly Potzner, Catherine Zimmermann, Angelia Espinal, Nina Buchtele, Michael Schwameis, Andrea Korhnfehl, Roman Brock, Thomas Staudinger, Stephanie-Susanne, Stecher Michaela Barnikel, Sófia Antón, Alexandra Pawlikowski, Akram Zaaqoq, Lan Anh Galloway, Caitlin Merley, Marc Csete, Luisa Quesada, Isabela Saba, Daisuke Kasugai, Hiroaki Hiraiwa, Taku Tanaka, Eva Marwali, Yoel Purnama, Santi Rahayu Dewayanti, Ardiyan, Dafsah Arifa Juzar, Debby Siagian, Yih-Sharng Chen, Indrek Ratsep, Andra-Maris Post, Piret Sillaots, Anneli Krund, Merili-Helen Lehiste, Tanel Lepik, Frank Manetta, Effe Mihelis, Iam Claire Sarmiento, Mangala Narasimhan, Michael Varrone, Mamoru Komats, Julia Garcia-Diaz, Catherine Harmon, S. Veena Satyapriya, Amar Bhatt, Nahush A. Mokadam, Alberto Uribe, Alicia Gonzalez, Haixia Shi, Johnny McKeown, Joshua Pasek, Juan Fiorda, Marco Echeverria, Rita Moreno, Bishoy Zakhary, Marco Cavana, Alberto Cucino, Giuseppe Foti, Marco Giani, Benedetta Fumagalli, Valentina Castagna, Andrea Dell’Amore, Paolo Navalesi, Hoi-Ping Shum, Alain Vuysteke, Asad Usman, Andrew Acker, Benjamin Smood, Blake Mergler, Federico Sertic, Madhu Subramanian, Alexandra Sperry, Nicolas Rizer, Erlina Burhan, Menaldi Rasmin, Ernita Akmal, Faya Sitompul, Navy Lolong, Bhat Naivedh, Simon Erickson, Peter Barrett, David Dean, Julia Daugherty, Antonio Loforte, Irfan Khan, Mohammed Abraar Quraishi, Olivia DeSantis, Dominic So, Darshana Kandamby, Jose M. Mandei, Hans Natanael, Eka YudhaLantang, Anastasia Lantang, Surya Oto Wijaya, Anna Jung, George Ng, Wing Yiu Ng, Shu Fang, Alexis Tabah, Megan Ratcliffe, Maree Duroux, Shingo Adachi, Shota Nakao, Pablo Blanco, Ana Prieto, Jesús Sánchez, Meghan Nicholson, Warwick Butt, Alyssa Serratore, Carmel Delzoppo, Pierre Janin, Elizabeth Yarad, Richard Totaro, Jennifer Coles, Bambang Pujo, Robert Balk, Andy Vissing, Esha Kapania, James Hays, Samuel Fox, Garrett Yantosh, Pavel Mishin, Saptadi Yuliarto, Kohar Hari Santoso, Susanthy Djajalaksana, Arie Zainul Fatoni, Masahiro Fukuda, Keibun Liu, Paolo Pelosi, Denise Battaglini, Juan Fernando Masa Jiménez, Diego Bastos, Sérgio Gaião, Desy Rusmawatiningtyas, Young-Jae Cho, Su Hwan Lee, Tatsuya Kawasaki, Laveena Munshi, Pranya Sakiyalak, Prompak Nitayavardhana, Tamara Seitz, Rakesh Arora, David Kent, Daniel Marino, Swapnil Parwar, Andrew Cheng, Jennene Miller, Shigeki Fujitani, Naoki Shimizu, Jai Madhok, Clark Owyang, Hergen Buscher, Claire Reynolds, Olavi Maasikas, Aleksan Beljantsev, Vladislav Mihnovits, Takako Akimoto, Mariko Aizawa, Kanako Horibe, Ryota Onodera, Meredith Young, Timothy George, Kiran Shekar, Niki McGuinness, Lacey Irvine, Brigid Flynn, Tomoyuki Endo, Kazuhiro Sugiyama, Keiki Shimizu, Kathleen Exconde, Leslie Lussier, Gösta Lotz, Maximilian Malfertheiner, Lars Maier, Esther Dreier, Neurinda Permata Kusumastuti, Colin McCloskey, Al-Awwab Dabaliz, Tarek B Elshazly, Josiah Smith, Konstanty S. Szuldrzynski, Piotr Bielański, Keith Wille, Ken Kuljit, S. Parhar, Kirsten M. Fiest, Cassidy Codan, Anmol Shahid, Mohamed Fayed, Timothy Evans, Rebekah Garcia, Ashley Gutierrez, Tae Song, Rebecca Rose, Suzanne Bennett, Denise Richardson, Giles Peek, Lovkesh Arora, Kristina Rappapport, Kristina Rudolph, Zita Sibenaller, Lori Stout, Alicia Walter, Daniel Herr, Nazli Vedadi, Shaun Thompson, Julie Hoffman, Xiaonan Ying, Ryan Kennedy, Muhammed Elhadi, Matthew Griffee, Anna Ciullo, Yuri Kida, Ricard Ferrer Roca, JordI Riera, Sofia Contreras, Cynthia Alegre, Christy Kay, Irene Fischer, Elizabeth Renner, Hayato Taniguci, John Fraser, Jacky Suen, Adrian Barnett, Nicole White, Kristen Gibbons, Simon Forsyth, Amanda Corley, India Pearse, Samuel Hinton, Gabriella Abbate, Halah Hassan, Silver Heinsar, Varun A Karnik, Katrina Ki, Hollier F. O’Neill, Nchafatso Obonyo, Leticia Pretti Pimenta, Janice D. Reid, Kei Sato, Aapeli Vuorinen, Karin S. Wildi, Emily S. Wilson, Stephanie Yerkovich, James Lee, Daniel Plotkin, Barbara Wanjiru Citarella, Laura Merson, Emma Hartley, Bastian Lubis, Takanari Ikeyama, Balu Bhaskar, Jae-Seung Jung, Shay McGuinness, Glenn Eastwood, Sandra Rossi Marta, Fabio Guarracino, Stacy Gerle, Emily Coxon, Bruno Claro, Daniel Loverde, Namrata Patil, Vieri Parrini, Angela McBride, Kathryn Negaard, Angela Ratsch, Ahmad Abdelaziz, Juan David Uribe, Adriano Peris, Mark Sanders, Dominic Emerson, Muhammad Kamal, Pedro Povoa, Roland Francis, Ali Cherif, Sunimol Joseph, Matteo Di Nardo, Micheal Heard, Kimberly Kyle, Ray A Blackwell, Patrick Biston, Hye Won Jeong, Reanna Smith, Yogi Prawira, Arturo Huerta Garcia, Nahikari Salterain, Bart Meyns, Marsha Moreno, Rajat Walia, Amit Mehta, Annette Schweda, Moh Supriatna, Cenk Kirakli, Melissa Williams, Kyung Hoon Kim, Alexandra Assad, Estefania Giraldo, Wojtek Karolak, Martin Balik, Elizabeth Pocock, Evan Gajkowski, Kanamoto Masafumi, Nicholas Barrett, Yoshihiro Takeyama, Sunghoon Park, Faizan Amin, Fina Meilyana Andriyani, Serhii Sudakevych, Magdalena Vera, Rodrigo Cornejo, Patrícia Schwarz, Ana Carolina Mardini, Thais de Paula, Ary Serpa Neto, Andrea Villoldo, Alexandre Siciliano Colafranceschi, Alejandro Ubeda Iglesias, Juan Granjean, Lívia Maria Garcia Melro, Giovana Fioravante Romualdo, Diego Gaia, Helmgton Souza, Filomena Galas, Rafael Máñez Mendiluce, Alejandra Sosa, Ignacio Martinez, Hiroshi Kurosawa, Juan Salgado, Beate Hugi-Mayr, Eric Charbonneau, Vitor Salvatore Barzilai, Veronica Monteiro, Rodrigo Ribeiro de Souza, Michael Harper, Hiroyuki Suzuki, Celina Adams, Jorge Brieva, George Nyale, Faisal Saleem Eltatar, Jihan Fatani, Husam Baeissa, Ayman AL Masri, Ahmed Rabie, Mok Yee Hui, Masahiro Yamane, Hanna Jung, Ayorinde Mojisola Margaret, Newell Nacpil, Katja Ruck, Rhonda Bakken, Claire Jara, Tim Felton, Lorenzo Berra, Bobby Shah, Arpan Chakraborty, Monika Cardona, Gerry Capatos, Bindu Akkanti, Abiodun Orija, Harsh Jain, Asami Ito, Brahim Housni, Sennen Low, Koji Iihara, Joselito Chavez, Kollengode Ramanathan, Gustavo Zabert, Krubin Naidoo, Ian Seppelt, Marlice VanDyk, Sarah MacDonald, Randy McGregor, Teka Siebenaler, Hannah Flynn, Kristi Lofton, Toshiyuki Aokage, Kazuaki Shigemitsu, Andrea Moscatelli, Giuseppe Fiorentino, Matthias Baumgaertel, Serge Eddy Mba, Jana Assy, Amelya Hutahaean, Holly Roush, Kay A Sichting, Francesco Alessandri, Debra Burns, Gavin Salt, Carl P. Garabedian, Jonathan Millar, Malcolm Sim, Adrian Mattke, Danny McAuley, Jawad Tadili, Tim Frenzel, Yaron Bar-Lavie, Aaron Blandino Ortiz, Jackie Stone, Antony Attokaran, Michael Farquharson, Brij Patel, Derek Gunning, Kenneth Baillie, Pia Watson, Kenji Tamai, Gede Ketut Sajinadiyasa, Dyah Kanyawati, Marcello Salgado, Assad Sassine, Bhirowo Yudo, Scott McCaul, Bongjin Lee, Sang Min Lee, Arnon Afek, Yoshiaki Iwashita, Bambang Pujo Semedi, Jack Metiva, Nicole Van Belle, Ignacio Martin-Loeches, Lenny Ivatt, Chia Yew Woon, Hyun Mi Kang, Timothy Smith, Erskine James, Nawar Al-Rawas, Yudai Iwasaki, Kenny Chan King-Chung, Vadim Gudzenko, Fabio Taccone, Fajar Perdhana, Yoan Lamarche, Joao Miguel Ribeiro, Nikola Bradic, Klaartje Van den Bossche, Oude Lansink, Gurmeet Singh, Gerdy Debeuckelaere, Henry T. Stelfox, Cassia Yi, Jennifer Elia, Thomas Tribble, Shyam Shankar, Raj Padmanabhan, Bill Hallinan, Luca Paoletti, Yolanda Leyva, Tatuma Fykuda, Jenelle Badulak, Jillian Koch, Amy Hackman, Lisa Janowaik, Deb Hernandez, Jennifer Osofsky, Katia Donadello, Aizah Lawang, Josh Fine, and Benjamin Davidson
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
OBJECTIVES:. Anemia has been associated with an increased risk of both cardiac arrest and stroke, frequent complications of COVID-19. The effect of hemoglobin level at ICU admission on a composite outcome of cardiac arrest or stroke in an international cohort of COVID-19 patients was investigated. DESIGN:. Retrospective analysis of prospectively collected database. SETTING:. A registry of COVID-19 patients admitted to ICUs at over 370 international sites was reviewed for patients diagnosed with cardiac arrest or stroke up to 30 days after ICU admission. Anemia was defined as: normal (hemoglobin ≥ 12.0 g/dL for women, ≥ 13.5 g/dL for men), mild (hemoglobin 10.0–11.9 g/dL for women, 10.0–13.4 g/dL for men), moderate (hemoglobin ≥ 8.0 and < 10.0 g/dL for women and men), and severe (hemoglobin < 8.0 g/dL for women and men). PATIENTS:. Patients older than 18 years with acute COVID-19 infection in the ICU. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. Of 6926 patients (median age = 59 yr, male = 65%), 760 patients (11.0%) experienced stroke (2.0%) and/or cardiac arrest (9.4%). Cardiac arrest or stroke was more common in patients with low hemoglobin, occurring in 12.8% of patients with normal hemoglobin, 13.3% of patients with mild anemia, and 16.7% of patients with moderate/severe anemia. Time to stroke or cardiac arrest by anemia status was analyzed using Cox proportional hazards regression with death as a competing risk. Covariates selected through clinical knowledge were age, sex, comorbidities (diabetes, hypertension, obesity, and cardiac or neurologic conditions), pandemic era, country income, mechanical ventilation, and extracorporeal membrane oxygenation. Moderate/severe anemia was associated with a higher risk of cardiac arrest or stroke (hazard ratio, 1.32; 95% CI, 1.05–1.67). CONCLUSIONS:. In an international registry of ICU patients with COVID-19, moderate/severe anemia was associated with increased hazard of cardiac arrest or stroke.
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- 2024
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43. Decreased Delta/Beta ratio index as the sleep state-independent electrophysiological signature of sleep state misperception in Insomnia disorder: A focus on the sleep onset and the whole night
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Elisabetta Fasiello, Maurizio Gorgoni, Andrea Galbiati, Marco Sforza, Francesca Berra, Serena Scarpelli, Valentina Alfonsi, Ludovica Annarumma, Francesca Casoni, Marco Zucconi, Vincenza Castronovo, Luigi Ferini-Strambi, and Luigi De Gennaro
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Insomnia disorder ,Sleep state misperception ,Sleep onset ,Topographic EEG ,Cortical hyperarousal ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Purpose: Sleep State Misperception (SSM) is described as the tendency of Insomnia Disorder (ID) patients to overestimate Sleep Latency (SL) and underestimate Total Sleep Time (TST). Literature exploring topographical components in ID with SSM is scarce and does not allow us to fully understand the potential mechanisms underlying this phenomenon. This study aims to evaluate the existence of sleep EEG topography alterations in ID patients associated with SSM compared to Healthy Controls (HC), focusing on two distinct periods: the Sleep Onset (SO) and the whole night. Methods: Twenty ID patients (mean age: 43.5 ± 12.7; 7 M/13F) and 18 HCs (mean age: 41.6 ± 11.9; 8 M/10F) underwent a night of Polysomnography (PSG) and completed sleep diaries the following morning upon awakening. Two SSM indices, referring to the misperception of SL (SLm) and TST (TSTm), were calculated by comparing objective and subjective sleep indices extracted by PSG and sleep diary. According to these indices, the entire sample was split into 4 sub-groups: ID +SLm vs HC –SLm; ID +TSTm vs HC –TSTm. Results: Considering the SO, the two-way mixed-design ANOVA showed a significant main effect of Groups pointing to a decreased delta/beta ratio in the whole scalp topography. Moreover, we found a significant interaction effect for the sigma and beta bands. Post Hoc tests showed higher sigma and beta power in anterior and temporo-parietal sites during the SO period in IDs +SLm compared to HC –SLm.Considering the whole night, the unpaired t-test revealed in IDs +TSTm significantly lower delta power during NREM, and lower delta/beta ratio index during NREM and REM sleep compared to HCs –TSTm.Finally, we found diffuse significant negative correlations between SSM indices and the delta/beta ratio during SO, NREM, and REM sleep. Conclusion: The main finding of the present study suggests that higher SL overestimation and TST underestimation are both phenomena related to diffuse cortical hyperarousal interpreted as a sleep state-independent electrophysiological correlate of the SSM, both during the SO and the whole night.
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- 2024
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44. Self-Perception of Mental Health and Exacerbated Social Inequalities Among Vulnerable Older Adults During the COVID-19 Pandemic in Brazil (2021–2023)
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Letícia Perticarrara Ferezin PhD, Rander Junior Rosa MS, Mônica Chiodi Toscano de Campos PhD, Thaís Zamboni Berra PhD, Heriederson Sávio Dias Moura PhD, Ariela Fehr Tártaro BSC, Murilo César do Nascimento PhD, Natacha Martins Ribeiro BSC, Juliana Soares Tenório de Araújo BSC, Fernanda Bruzadelli Paulino da Costa BSC, Reginaldo Bazon Vaz Tavares BSC, Yan Mathias Alves MS, Titilade Kehinde Ayandeyi Teibo MS, Regina Celia Fiorati PhD, Severina Alice da Costa Uchoa PhD, Rosa Maria Pinheiro Souza PhD, Ione Carvalho Pinto PhD, and Ricardo Alexandre Arcêncio PhD
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Geriatrics ,RC952-954.6 - Abstract
This study analyzes the self-perception of mental health of socially vulnerable elderly people during the COVID-19 crisis in Brazil. Conducted across all state capitals from February 2021 to October 2023, it included 366 participants living in various conditions such as camps, street situations, slums, and communities. The average age was 66.7 years, with a majority being male (59.0%), of Black or Brown race/color (62.3%), and earning below one minimum wage (36.6%). Findings revealed that older adults in street situations, experiencing psychological manifestations like sleep disturbances due to the pandemic, tended to assess their mental health more negatively. In contrast, older men of white race/color without such manifestations, and those practicing strategies like physical activity or relaxation, were less likely to perceive their mental health as poor. Addressing housing, implementing health strategies, and recognizing sample and regional complexities are crucial interventions for older adults in street situations.
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- 2024
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45. Effectiveness of Elements of Social Behavior Change Activities in Nutrition-Sensitive Agriculture Programs: A Systematic Review
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Tsedenia Tewodros, Carolina X Escobar, Liris S Berra, and Amy Webb Girard
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nutrition ,agriculture ,social behavior change ,diet diversity ,project implementation ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Background: Limited research exists on the specific approaches and behavior change techniques (BCT) used in nutrition-sensitive agriculture (NSA) programs and their effects on diet diversity. Objectives: We aimed to describe nutrition-related social behavior change (SBC) in the context of NSA and quantify the effectiveness of different SBC components of NSA programs in improving diet diversity. Methods: We searched PubMed, Embase, Web of Science, the International Food Policy and Research Institute repository, and Agricola for articles published between 2000 and 2023. We identified the agricultural activities each project used as a pathway to improved nutrition (ag-nutrition pathways), identified SBC approaches used by each project, and coded BCTs using validated coding protocols. Effectiveness ratios (ERs) were calculated to assess pathways, approaches, and BCTs in relation to dietary diversity outcomes (minimum diet diversity for children, child dietary diversity score, and women’s dietary diversity). Results: Of 65 included NSA interventions, the most used agriculture-to-nutrition pathways included 1) agricultural production for home consumption (n = 61); 2) women’s empowerment (n = 36); and 3) agricultural income (n = 37) pathways. The most used SBC approaches were interpersonal communication (IPC, n = 59) and community-based approaches (n = 53). Frequently used BCTs included “instructions on how to perform the behavior” (n = 65), “social support (unspecified)” (n = 43), and using a “credible source” (n = 43). The increased production for the home consumption pathway, IPC approach, and the BCT “behavioral practice” had high ERs for diet diversity outcomes. Conclusions: Although the agricultural production for home consumption pathway to improved nutrition had the highest ERs for diet diversity, other pathways, such as income generation and reducing wastage, hold promise and require additional investigation. The most commonly applied BCTs focused on information dissemination; however, participatory BCTs related to behavioral demonstration, and behavioral practice had higher ERs. Findings indicate a need to test less frequently utilized SBC components to determine effectiveness.This trial was registered at PROSPERO (=https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=179016) as CRD42020179016.
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- 2024
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46. Identifying hotspots of people diagnosed of tuberculosis with addiction to alcohol, tobacco, and other drugs through a geospatial intelligence application in communities from Southern Brazil
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Scholze, Alessandro Rolim, Delpino, Felipe Mendes, Alves, Luana Seles, Alves, Josilene Dalia, Berra, Thais Zamboni, Ramos, Antonio Carlos Vieira, Fuentealba-Torres, Miguel, Fronteira, Ines, and Arcencio, Ricardo Alexandre
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- 2022
47. A Low Complexity Iterative SC-FDE Receiver for Massive MIMO Systems.
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Salah Berra, Sourav Chakraborty 0006, and Rui Dinis 0001
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- 2024
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48. Combined Newton-Gradient Method for Constrained Root-Finding in Chemical Reaction Networks.
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Silvia Berra, Alessandro La Torraca, Federico Benvenuto, and Sara Sommariva
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- 2024
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49. Some extensions of classes involving pair of weights related to the boundedness of multilinear commutators associated to generalized fractional integral operators
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Berra, Fabio, Pradolini, Gladis, and Recchi, Jorgelina
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Mathematics - Classical Analysis and ODEs ,26A33, 26D10 - Abstract
We deal with the boundedness properties of higher order commutators related to some generalizations of the multilinear fractional integral operator of order $m$, $I_\alpha ^m$, from a product of weighted Lebesgue spaces into adequate weighted Lipschitz spaces, extending some previous estimates for the linear case. Our study includes two different types of commutators and sufficient conditions on the weights in order to guarantee the continuity properties described above. We also exhibit the optimal range of the parameters involved. The optimality is understood in the sense that the parameters defining the corresponding spaces belong to a certain region, being the weights trivial outside of it. We further show examples of weights for the class which cover the mentioned area., Comment: 30 pages. arXiv admin note: text overlap with arXiv:2203.04247
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- 2022
50. Mixed inequalities for operators associated to critical radius functions with applications to Schr\'odinger type operators
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Berra, Fabio, Pradolini, Gladis, and Quijano, Pablo
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Mathematics - Analysis of PDEs ,42B20, 42B25, 35J10 - Abstract
We obtain weighted mixed inequalities for operators associated to a critical radius function. We consider Schr\"odinger Calder\'on-Zygmund operators of $(s,\delta)$ type, for $1
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- 2022
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