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134 results on '"Bernhagen, Juergen"'

4. Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis

Author

Wirtz, Theresa H., Reuken, Philipp A., Jansen, Christian, Fischer, Petra, Bergmann, Irina, Backhaus, Christina, Emontzpohl, Christoph, Reißing, Johanna, Brandt, Elisa F., Koenen, M. Teresa, Schneider, Kai M., Schierwagen, Robert, Brol, Maximilian J., Chang, Johannes, Zimmermann, Henning W., Köse-Vogel, Nilay, Eggermann, Thomas, Kurth, Ingo, Stoppe, Christian, Bucala, Richard, Bernhagen, Jürgen, Praktiknjo, Michael, Stallmach, Andreas, Trautwein, Christian, Trebicka, Jonel, Bruns, Tony, and Berres, Marie-Luise

Published
2021
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5. Chemokine-like MDL proteins modulate flowering time and innate immunity in plants

Author

Gruner, Katrin, Leissing, Franz, Sinitski, Dzmitry, Thieron, Hannah, Axstmann, Christian, Baumgarten, Kira, Reinstädler, Anja, Winkler, Pascal, Altmann, Melina, Flatley, Andrew, Jaouannet, Maëlle, Zienkiewicz, Krzysztof, Feussner, Ivo, Keller, Harald, Coustau, Christine, Falter-Braun, Pascal, Feederle, Regina, Bernhagen, Jürgen, and Panstruga, Ralph

Published
2021
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7. Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice

Author

Tilstam, Pathricia V., Soppert, Josefin, Hemmers, Christian, Harlacher, Eva, Döring, Yvonne, van der Vorst, Emiel P.C., Schulte, Corinna, Alampour-Rajabi, Setareh, Theelen, Wendy, Asare, Yaw, de Winther, Menno P.J., Lawrence, Toby, Bernhagen, Jürgen, Schober, Andreas, Zernecke, Alma, Jankowski, Joachim, Weber, Christian, and Noels, Heidi

Published
2020
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9. CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.

Author

Immler, Roland, Nussbaumer, Katrin, Doerner, Axel, El Bounkari, Omar, Huber, Silke, Abisch, Janine, Napoli, Matteo, Schmidt, Sarah, Margraf, Andreas, Pruenster, Monika, Rohwedder, Ina, Lange-Sperandio, Baerbel, Mall, Marcus A., de Jong, Renske, Ohnmacht, Caspar, Bernhagen, Juergen, Voehringer, David, Marth, Jamey D., Frommhold, David, and Sperandio, Markus

Subjects
EOSINOPHILS, HOMEOSTASIS, PERITONEUM, ALLERGIES, ADIPOSE tissues
Abstract

Eosinophil recruitment is a pathological hallmark of many allergic and helminthic diseases. Here, we investigated chemokine receptor CCR3-induced eosinophil recruitment in sialyltransferase St3gal4-/- mice. We found a marked decrease in eosinophil extravasation into CCL11-stimulated cremaster muscles and into the inflamed peritoneal cavity of St3gal4-/- mice. Ex vivo flow chamber assays uncovered reduced adhesion of St3gal4-/- compared to wild type eosinophils. Using flow cytometry, we show reduced binding of CCL11 to St3gal4-/- eosinophils. Further, we noted reduced binding of CCL11 to its chemokine receptor CCR3 isolated from St3gal4-/- eosinophils. This was accompanied by almost absent CCR3 internalization of CCL11-stimulated St3gal4-/- eosinophils. Applying an ovalbumin-induced allergic airway disease model, we found a dramatic reduction in eosinophil numbers in bronchoalveolar lavage fluid following intratracheal challenge with ovalbumin in St3gal4-deficient mice. Finally, we also investigated tissue-resident eosinophils under homeostatic conditions and found reduced resident eosinophil numbers in the thymus and adipose tissue in the absence of ST3Gal-IV. Taken together, our results demonstrate an important role of ST3Gal-IV in CCR3-induced eosinophil recruitment in vivo rendering this enzyme an attractive target in reducing unwanted eosinophil infiltration in various disorders including allergic diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo

Author

Asare, Yaw, Ommer, Miriam, Azombo, Florence. A., Alampour-Rajabi, Setareh, Sternkopf, Marieke, Sanati, Maryam, Gijbels, Marion J., Schmitz, Corinna, Sinitski, Dzmitry, Tilstam, Pathricia V., Lue, Hongqi, Gessner, André, Lange, Denise, Schmid, Johannes A., Weber, Christian, Dichgans, Martin, Jankowski, Joachim, Pardi, Ruggero, de Winther, Menno P. J., Noels, Heidi, and Bernhagen, Jürgen

Published
2017

21. Structures ofArabidopsis thalianaMDL Proteins and Synergistic Effects with the Cytokine MIF on Human Receptors

Author

Spiller, Lukas, primary, Ramu, Manjula, additional, Leissing, Franz, additional, Basquin, Jerome, additional, Bourilhon, Priscila, additional, Sinitski, Dzimitry, additional, Brandhofer, Markus, additional, Levecque, Sophie C., additional, Sabelleck, Bjoern, additional, Feederle, Regina, additional, Flatley, Andrew, additional, Panstruga, Ralph, additional, Bernhagen, Juergen, additional, and Lolis, Elias, additional

Published
2023
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25. Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium

Author

Schiwon, Marzena, Weisheit, Christina, Franken, Lars, Gutweiler, Sebastian, Dixit, Akanksha, Meyer-Schwesinger, Catherine, Pohl, Judith-Mira, Maurice, Nicholas J., Thiebes, Stephanie, Lorenz, Kristina, Quast, Thomas, Fuhrmann, Martin, Baumgarten, Georg, Lohse, Martin J., Opdenakker, Ghislain, Bernhagen, Jürgen, Bucala, Rick, Panzer, Ulf, Kolanus, Waldemar, Gröne, Hermann-Josef, Garbi, Natalio, Kastenmüller, Wolfgang, Knolle, Percy A., Kurts, Christian, and Engel, Daniel R.

Published
2014
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26. Abstract P1110: Identification Of Timp-1 As A Downstream Target Of The Coronary Artery Disease Risk Factor Adamts-7 In Atherosclerosis

Author

Sharifi, M. Amin, primary, Wierer, Michael, additional, Milic, Jelena, additional, Moggio, Aldo, additional, Mueller, Philipp, additional, Werner, Julia, additional, Sager, Hendrik, additional, Bernhagen, Juergen, additional, Mann, Matthias, additional, Schunkert, Heribert, additional, and Kessler, Thorsten, additional

Published
2022
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27. Gremlin-1 Is an Inhibitor of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerotic Plaque Growth in ApoE−/− Mice

Author

Müller, Iris, Schönberger, Tanja, Schneider, Martina, Borst, Oliver, Ziegler, Melanie, Seizer, Peter, Leder, Christoph, Müller, Karin, Lang, Michael, Appenzeller, Florian, Lunov, Oleg, Büchele, Berthold, Fahrleitner, Manuela, Olbrich, Marcus, Langer, Harald, Geisler, Tobias, Lang, Florian, Chatterjee, Madhumita, de Boer, Jan Freark, Tietge, Uwe J.F., Bernhagen, Jürgen, Simmet, Thomas, and Gawaz, Meinrad

Published
2013
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48. Differential Role for Activating FcγRIII in Neointima Formation After Arterial Injury and Diet-Induced Chronic Atherosclerosis in Apolipoprotein E-Deficient Mice

Author

Asare, Yaw, Koehncke, Janine, Selle, Jaco, Simsekyilmaz, Sakine, Jankowski, Joachim, Shagdarsuren, Gansuvd, Gessner, Johannes E., Bernhagen, Juergen, Shagdarsuren, Erdenechimeg, Pathologie, and RS: Carim - B07 The vulnerable plaque: makers and markers

Subjects
LESIONS, IGG, LOW-DENSITY-LIPOPROTEIN, INHIBITION, PROGRESSION, MECHANISMS, RECEPTORS, inflammation, Fc gamma receptors, ANTIBODIES, cytokine, IMMUNE-COMPLEXES, hyperlipidemia, neointima formation, complement, PROTECTION, atherosclerosis
Abstract

Atherogenesis and arterial remodeling following mechanical injury are driven by inflammation and mononuclear cell infiltration. The binding of immune complexes (ICs) to immunoglobulin (Ig)-Fc gamma receptors (Fc gamma Rs) on most innate and adaptive immune cells induces a variety of inflammatory responses that promote atherogenesis. Here, we studied the role of Fc gamma RIII in neointima formation after arterial injury in atherosclerosis-prone mice and compared the outcome and mechanism to that of Fc gamma RIII in diet-induced "chronic" atherosclerosis.Fc gamma rIII(-/-)/Apoe(-/-)and controlApoe(-/-)mice were subjected to wire-induced endothelial denudation of the carotid artery while on high-fat diet (HFD).Fc gamma rIIIdeficiency mitigated neointimal plaque formation and lesional macrophage accumulation, and enhanced neointimal vascular smooth muscle cell (VSMC) numbers. This went along with a reduced expression of tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1/CCL2), and vascular cell adhesion molecule-1 (VCAM-1) in the neointimal lesions. Interestingly, in a chronic model of diet-induced atherosclerosis, we unraveled a dichotomic role of Fc gamma RIII in an early versus advanced stage of the disease. WhileFc gamma rIIIdeficiency conferred atheroprotection in the early stage, it promoted atherosclerosis in advanced stages. To this end,Fc gamma rIIIdeficiency attenuated pro-inflammatory responses in early atherosclerosis but promoted these events in advanced stages. Analysis of the mechanism(s) underlying the athero-promoting effect ofFc gamma rIIIdeficiency in late-stage atherosclerosis revealed increased serum levels of anti-oxidized-LDL immunoglobulins IgG2c and IgG2b. This was paralleled by enhanced lesional accumulation of IgGs without affecting levels of complement-activated products C5a or C5ar1, Fc gamma RII, and Fc gamma RIV. Moreover,Fc gamma rIII-deficient macrophages expressed moreFc gamma rII,Tnf-alpha, andIl-1 beta mRNA when exposed to IgG1 or oxLDL-IgG1 ICsin vitro, and peripheral CD4+ and CD8+ T-cell levels were altered. Collectively, our data suggest that deficiency of activatingFc gamma RIIIlimits neointima formation after arterial injury in atherosclerosis-prone mice as well as early stage chronic atherosclerosis, but augments late-stage atherosclerosis suggesting a dual role of Fc gamma RIII in atherogenic inflammation.

Published
2020

49. MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model

Author

Tilstam, Pathricia Veronica, Schulte, Wibke, Holowka, Thomas, Kim, Bong-Sung, Nouws, Jessica, Sauler, Maor, Piecychna, Marta, Pantouris, Georgios, Lolis, Elias, Leng, Lin, Bernhagen, Juergen, Fingerle-Rowson, Guenter, Bucala, Richard, Tilstam, Pathricia Veronica, Schulte, Wibke, Holowka, Thomas, Kim, Bong-Sung, Nouws, Jessica, Sauler, Maor, Piecychna, Marta, Pantouris, Georgios, Lolis, Elias, Leng, Lin, Bernhagen, Juergen, Fingerle-Rowson, Guenter, and Bucala, Richard

Abstract

Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and anti-MIF antibody improves survival in experimental models when administered 8 hours after infectious insult. The recent description of a second MIF superfamily member, D-dopachrometautomerase (D-DT/MIF-2), prompted closer investigation of MIF-dependent responses. We subjected Mif(-/-) and Mif-2(-/-) mice to polymicrobial sepsis and observed a survival benefit with Mif but not Mif-2 deficiency. Survival was associated with reduced numbers of small peritoneal macrophages (SPMs) that, in contrast to large peritoneal macrophages (LPMs), were recruited into the peritoneal cavity. LPMs produced higher quantities of MIF than SPMs, but SPMs expressed higher levels of inflammatory cytokines and the MIF receptors CD74 and CXCR2. Adoptive transfer of WT SPMs into Mif(-/-) hosts reduced the protective effect of Mif deficiency in polymicrobial sepsis. Notably, MIF-2 lacks the pseudo-(E) LR motif present in MIF that mediates CXCR2 engagement and SPM migration, supporting a specific role for MIF in the recruitment and accumulation of inflammatory SPMs.

Published
2021

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