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7. Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort

Author

Urowitz, MB, Gladman, DD, Anderson, NM, Su, J, Romero-Diaz, J, Bae, SC, Fortin, PR, Sanchez-Guerrero, J, Clarke, A, Bernatsky, S, Gordon, C, Hanly, JG, Wallace, DJ, Isenberg, D, Rahman, A, Merrill, J, Ginzler, E, Alarcón, GS, Fessler, BF, Petri, M, Bruce, IN, Khamashta, M, Aranow, C, Dooley, M, Manzi, S, Ramsey-Goldman, R, Sturfelt, G, Nived, O, Steinsson, K, Zoma, A, Ruiz-Irastorza, G, Lim, S, Kalunian, KC, Ỉnanç, M, van Vollenhoven, R, Ramos-Casals, M, Kamen, DL, Jacobsen, S, Peschken, C, Askanase, A, and Stoll, T

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Prevention, Atherosclerosis, Lupus, Cardiovascular, Autoimmune Disease, Clinical Research, Evaluation of treatments and therapeutic interventions, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, 6.1 Pharmaceuticals, Inflammatory and immune system, Cardiovascular Disease, Inflammation, Systemic Lupus Erythematosus, Clinical sciences, Immunology
Abstract

ObjectiveTo describe the frequency of myocardial infarction (MI) prior to the diagnosis of systemic lupus erythematosus (SLE) and within the first 2 years of follow-up.MethodsThe systemic lupus international collaborating clinics (SLICC) atherosclerosis inception cohort enters patients within 15 months of SLE diagnosis. MIs were reported and attributed on a specialised vascular event form. MIs were confirmed by one or more of the following: abnormal ECG, typical or atypical symptoms with ECG abnormalities and elevated enzymes (≥2 times upper limit of normal), or abnormal stress test, echocardiogram, nuclear scan or angiogram. Descriptive statistics were used.Results31 of 1848 patients who entered the cohort had an MI. Of those, 23 patients had an MI prior to SLE diagnosis or within the first 2 years of disease. Of the 23 patients studied, 60.9% were female, 78.3% were Caucasian, 8.7% black, 8.7% Hispanic and 4.3% other. The mean age at SLE diagnosis was 52.5±15.0 years. Of the 23 MIs that occurred, 16 MIs occurred at a mean of 6.1±7.0 years prior to diagnosis and 7 occurred within the first 2 years of follow-up. Risk factors associated with early MI in univariate analysis are male sex, Caucasian, older age at diagnosis, hypertension, hypercholesterolaemia, family history of MI and smoking. In multivariate analysis only age (OR=1.06 95% CI 1.03 to 1.09), hypertension (OR=5.01, 95% CI 1.38 to 18.23), hypercholesterolaemia (OR=4.43, 95% CI 1.51 to 12.99) and smoking (OR=7.50, 95% CI 2.38 to 23.57) remained significant risk factors.ConclusionsIn some patients with lupus, MI may develop even before the diagnosis of SLE or shortly thereafter, suggesting that there may be a link between autoimmune inflammation and atherosclerosis.

Published
2016

10. Anti-C1q antibodies in systemic lupus erythematosus

Author

Orbai, A-M, Truedsson, L, Sturfelt, G, Nived, O, Fang, H, Alarcón, GS, Gordon, C, Merrill, Jt, Fortin, PR, Bruce, IN, Isenberg, DA, Wallace, DJ, Ramsey-Goldman, R, Bae, S-C, Hanly, JG, Sanchez-Guerrero, J, Clarke, AE, Aranow, CB, Manzi, S, Urowitz, MB, Gladman, DD, Kalunian, KC, Costner, MI, Werth, VP, Zoma, A, Bernatsky, S, Ruiz-Irastorza, G, Khamashta, MA, Jacobsen, S, Buyon, JP, Maddison, P, Dooley, MA, Van Vollenhoven, RF, Ginzler, E, Stoll, T, Peschken, C, Jorizzo, JL, Callen, JP, Lim, SS, Fessler, BJ, Inanc, M, Kamen, DL, Rahman, A, Steinsson, K, Franks, AG, Sigler, L, Hameed, S, Pham, N, Brey, R, Weisman, MH, McGwin, G, Magder, LS, and Petri, M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Lupus, Clinical Research, Autoimmune Disease, Inflammatory and immune system, Adult, Antibodies, Antinuclear, Case-Control Studies, Complement C1q, Complement System Proteins, Cross-Sectional Studies, DNA, Female, Humans, Lupus Erythematosus, Systemic, Lupus Nephritis, Male, Middle Aged, Proteinuria, Rheumatic Diseases, Sensitivity and Specificity, Young Adult, Anti-dsDNA antibodies, renal lupus, systemic lupus erythematosus, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectiveAnti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study.MethodsInformation and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA.ResultsPrevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8-4, p

Published
2015

11. Factors associated with waiting times for persons with rheumatic conditions in multidisciplinary pain treatment facilities

Author

Deslauriers S, Roy JS, Bernatsky S, Feldman DE, Pinard AM, Desmeules F, Fitzcharles MA, and Perreault K

Subjects
access, waiting time, rheumatic conditions, chronic pain, multidisciplinary pain treatment facilities, Medicine (General), R5-920
Abstract

Simon Deslauriers,1,2 Jean-Sébastien Roy,1,2 Sasha Bernatsky,3–5 Debbie E Feldman,6–8 Anne Marie Pinard,1,2,9 François Desmeules,6,10 Mary-Ann Fitzcharles,3,4 Kadija Perreault1,21Center for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS), Québec, QC, Canada; 2Faculty of Medicine, Université Laval, Québec, QC, Canada; 3McGill University Health Centre (MUHC), Montréal, QC, Canada; 4Faculty of Medicine, McGill University, Montréal, QC, Canada; 5Research Institute of the McGill University Health Centre (RI-MUHC), Montréal, QC, Canada; 6Faculty of Medicine, Université de Montréal, Montréal, QC, Canada; 7Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), Montréal, QC, Canada; 8Public Health Research Institute of Université de Montréal, Montréal, QC, Canada; 9Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, Canada; 10Maisonneuve-Rosemont Hospital (CRHMR) Research Center, Montréal, QC, CanadaObjectives: Access to multidisciplinary pain treatment facilities (MPTF) in Canada is limited by long waiting lists. However, little is known about the factors associated with access to MPTF specifically for persons with rheumatic conditions. This study aimed to 1) determine the waiting time for services in publicly funded MPTF for persons with rheumatic conditions in the province of Quebec, Canada, as well as 2) identify the factors associated with waiting time.Methods: This study was conducted using the Quebec Pain Registry, a large database of patients who received pain management services in MPTF. Sociodemographic and clinical variables were assessed for potential associations with waiting time. Descriptive, bivariate analyses and multiple linear regression analyses were conducted.Results: A total of 3,665 patients with rheumatic conditions were identified within the registry. Patients had a mean age of 55±14 years and the majority were women (65.7%). The average waiting time was 241.2±308.9 days (median=126), with 34.2% of the patients waiting longer than 6 months before having a first appointment. Results indicate that longer pain duration, lower household income, pain onset following a motor vehicle accident, having fibromyalgia, being on permanent disability or unemployed and being referred by a family physician (versus specialist) were significantly associated with longer waiting times.Conclusions: Many patients with rheumatic conditions (especially fibromyalgia) face long delays before receiving services in Quebec’s MPTF. This study identified several factors associated with waiting time and emphasizes the need to improve access to pain management services.Keywords: access, waiting time, rheumatic conditions, chronic pain, multidisciplinary pain treatment facilities

Published
2019

12. Cancer risk in childhood-onset systemic lupus

Author

von Scheven, Emily, Bernatsky, S, Clarke, AE, Labrecque, J, von, E, Schanberg, LE, Silverman, ED, Brunner, HI, Haines, KA, Cron, RQ, and O'Neil, KM

Abstract

Introduction: The aim of this study was to assess cancer incidence in childhood-onset systemic lupus erythematosus (SLE).Methods: We ascertained cancers within SLE registries at 10 pediatric centers. Subjects were linked to cancer registries for the observ

Published
2013

13. Breast Cancer in Systemic Lupus Erythematosus

Author

Cloutier, B Tessier, Clarke, AE, Ramsey-Goldman, R, Wang, Y, Foulkes, W, Gordon, C, Hansen, JE, Yelin, E, Urowitz, MB, Gladman, D, Fortin, PR, Wallace, DJ, Petri, M, Manzi, S, Ginzler, EM, Labrecque, J, Edworthy, S, Dooley, MA, Senécal, JL, Peschken, CA, Bae, SC, Isenberg, D, Rahman, A, Ruiz-Irastorza, G, Hanly, JG, Jacobsen, S, Nived, O, Witte, T, Criswell, LA, Barr, SG, Dreyer, L, Sturfelt, G, and Bernatsky, S

Subjects
Clinical Research, Breast Cancer, Cancer, Lupus, Autoimmune Disease, Adult, Aged, Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Cohort Studies, Disease Susceptibility, Female, Humans, Logistic Models, Lupus Erythematosus, Systemic, Middle Aged, Multivariate Analysis, Odds Ratio, Risk Factors, Breast cancer, Systemic lupus erythematosus, Histopathology, Epidemiology, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

ObjectiveEvidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries.MethodsInformation on age, SLE duration, cancer date, and histology was available. We analyzed information on histological type and performed multivariate logistic regression analyses of histological types according to age, SLE duration, and calendar year.ResultsWe studied 180 breast cancers in the SLE cohort. Of the 155 cases with histology information, 11 were referred to simply as 'carcinoma not otherwise specified'. In the remaining 144 breast cancers, the most common histological type was ductal carcinoma (n = 95; 66%) followed by lobular adenocarcinoma (n = 11; 8%), 15 cancers were of mixed histology, and the remaining ones were special types. In our regression analyses, the independent risk factors for lobular versus ductal carcinoma was age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.01-1.14] and for the 'special' subtypes it was age (OR 1.06, 95% CI 1.01-1.10) and SLE duration (OR 1.05, 95% CI 1.00-1.11).ConclusionsGenerally, up to 80% of breast cancers are ductal carcinomas. Though our results are not definitive, in the breast cancers that occur in SLE, there may be a slight decrease in the ductal histological type. In our analyses, age and SLE duration were independent predictors of histological status.

Published
2013

18. A170 ADVERSE EVENTS & SEROLOGICAL RESPONSES FOLLOWING SARS-COV-2 VACCINATION IN INDIVIDUALS WITH INFLAMMATORY BOWEL DISEASE

Author

Markovinovic, A, primary, Herauf, M, additional, Quan, J, additional, Hracs, L, additional, Windsor, J W, additional, Sharifi, N, additional, Coward, S, additional, Caplan, L, additional, Gorospe, J, additional, Ma, C, additional, Panaccione, R, additional, Ingram, R, additional, Kanji, J, additional, Tipples, G, additional, Holodinsky, J, additional, Berstein, C, additional, Mahoney, D, additional, Bernatsky, S, additional, Benchimol, E, additional, and Kaplan, G G, additional

Published
2023
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19. Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes.

Author

Choi, M. Y., Hanly, J., Bae, S.-C., Romero-Diaz, J., Sanchez-Guerrero, J., Bernatsky, S., Wallace, D. J., Isenberg, D. A., Rahman, A., Merrill, J. T., Fortin, P. R., Ramsey-Goldman, R., Manzi, S., Jönsen, A., Alarcón, G. S., van Vollenhoven C. Aranow M. Mackay, R. F., Ruiz-Irastorza, G., Kalunian, K., Kamen, D. L., and Askanase, A.

Published
2023
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20. S15.2 Severe non-adherence to hydroxychloroquine is associated with flares, early damage, and mortality in systemic lupus erythematosus: data from 660 patients from the slicc inception cohort

Author

Nguyen, Y, primary, Blanchet, B, additional, Urowitz, MB, additional, Hanly, JG, additional, Gordon, C, additional, Bae, S, additional, Romero-Dia, J, additional, Sanchez-Guerrero, J, additional, Clarke, AE, additional, Bernatsky, S, additional, Wallace, DJ, additional, Isenberg, DA, additional, Rahman, A, additional, Merrill, JT, additional, Fortin, PR, additional, Gladman, DD, additional, Bruce, IN, additional, Petri, M, additional, Ginzler, EM, additional, Dooley, MA, additional, Ramsey-Goldman, R, additional, Manzi, S, additional, Jönsen, A, additional, Alarcón, GS, additional, Van Vollenhoven, RF, additional, Aranow, C, additional, Le Gurn, V, additional, Mackay, M, additional, Ruiz-Irastorza, G, additional, Lin, S, additional, Inanc, M, additional, Kalunian, KC, additional, Jacobsen, S, additional, Peschken, CA, additional, Kamen, DL, additional, Askanase, A, additional, Buyon, J, additional, and Costedoat-Chalumeau, N, additional

Published
2022
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21. Impact of the COVID-19 pandemic on maternal mental health during pregnancy: The CONCEPTION study – Phase I

Author

Berard, A., primary, Lacasse, A., additional, Gomez, Y.-H., additional, Gorgui, J., additional, Côté, S., additional, King, S., additional, Tchuente, V., additional, Muanda, F., additional, Lumu, Y., additional, Boucoiran, I., additional, Nuyt, A.-M., additional, Quach, C., additional, Ferreira, E., additional, Kaul, P., additional, Winquist, B., additional, O’Donnell, K., additional, Eltonsy, S., additional, Château, D., additional, Zhao, J.-P., additional, Hanley, G., additional, Oberlander, T., additional, Kassai, B., additional, Mainbourg, S., additional, Bernatsky, S., additional, Vinet, É., additional, Brodeur-Doucet, A., additional, Demers, J., additional, Richebé, P., additional, Zaphiratos, V., additional, Wang, C., additional, and Wang, X., additional

Published
2022
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27. OP0286 CHARACTERISTICS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE (COVID-19 GRA)

Author

Ugarte-Gil, M. F., primary, Alarcon, G. S., additional, Seet, A., additional, Izadi, Z., additional, Reategui Sokolova, C., additional, Clarke, A. E., additional, Wise, L., additional, Pons-Estel, G., additional, Santos, M. J., additional, Bernatsky, S., additional, Mathias, L., additional, Lim, N., additional, Sparks, J., additional, Wallace, Z., additional, Hyrich, K., additional, Strangfeld, A., additional, Gossec, L., additional, Carmona, L., additional, Mateus, E., additional, Lawson-Tovey, S., additional, Trupin, L., additional, Rush, S., additional, Schmajuk, G., additional, Katz, P., additional, Jacobsohn, L., additional, Al Emadi, S., additional, Gilbert, E., additional, Duarte-Garcia, A., additional, Valenzuela-Almada, M., additional, Hsu, T., additional, D’silva, K., additional, Serling-Boyd, N., additional, Dieudé, P., additional, Nikiphorou, E., additional, Kronzer, V., additional, Singh, N., additional, Wallace, B., additional, Akpabio, A., additional, Thomas, R., additional, Bhana, S., additional, Costello, W., additional, Grainger, R., additional, Hausmann, J., additional, Liew, J., additional, Sirotich, E., additional, Sufka, P., additional, Robinson, P., additional, Machado, P., additional, Gianfrancesco, M., additional, and Yazdany, J., additional

Published
2021
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31. OP0289 LLDAS (LOW LUPUS DISEASE ACTIVITY STATE), LOW DISEASE ACTIVITY (LDA) AND REMISSION (ON- OR OFF-TREATMENT) PREVENT DAMAGE ACCRUAL IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENTS IN A MULTINATIONAL MULTICENTER COHORT

Author

Ugarte-Gil, M. F., primary, Hanly, J., additional, Urowitz, M. B., additional, Gordon, C., additional, Bae, S. C., additional, Romero-Diaz, J., additional, Sanchez-Guerrero, J., additional, Bernatsky, S., additional, Clarke, A. E., additional, Wallace, D. J., additional, Isenberg, D., additional, Rahman, A., additional, Merrill, J. T., additional, Fortin, P., additional, Gladman, D. D., additional, Bruce, I. N., additional, Petri, M. A., additional, Ginzler, E. M., additional, Dooley, M. A., additional, Ramsey-Goldman, R., additional, Manzi, S., additional, Jonsen, A., additional, Van Vollenhoven, R., additional, Aranow, C., additional, Mackay, M., additional, Ruiz-Irastorza, G., additional, Lim, S. S., additional, Inanc, M., additional, Kalunian, K. C., additional, Jacobsen, S., additional, Peschken, C., additional, Kamen, D. L., additional, Askanase, A., additional, Pons-Estel, B., additional, and Alarcon, G. S., additional

Published
2021
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33. POS0050 ARE PATIENTS WITH IMMUNE MEDIATED INFLAMMATORY DISEASES (IMID) MORE LIKELY TO RECEIVE COVID-19 TESTS AND TEST POSITIVE FOR SARS-COV-2? A MATCHED POPULATION-BASED STUDY

Author

Eder, L., primary, Croxford, R., additional, Drucker, A., additional, Mendel, A., additional, Bindee, K., additional, Touma, Z., additional, Johnson, S., additional, Cook, R., additional, Bernatsky, S., additional, Haroon, N., additional, and Widdifield, J., additional

Published
2021
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37. Lung cancer in systemic lupus erythematosus

Author

Bin, J., Bernatsky, S., Gordon, C., Boivin, J.-F., Ginzler, E., Gladman, D., Fortin, P.R., Urowitz, M., Manzi, S., Isenberg, D., Rahman, A., Petri, M., Nived, O., Sturfeldt, G., Ramsey-Goldman, R., and Clarke, A.E.

Published
2007
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40. Autoantibodies as biomarkers for the prediction of neuropsychiatric events in systemic lupus erythematosus

Author

Hanly, J G, Urowitz, M B, Su, L, Bae, S-C, Gordon, C, Clarke, A, Bernatsky, S, Vasudevan, A, Isenberg, D, Rahman, A, Wallace, D J, Fortin, P R, Gladman, D, Romero-Dirz, J, Sanchez-Guerrero, J, Dooley, M A, Bruce, I, Steinsson, K, Khamashta, M, Manzi, S, Ramsey-Goldman, R, Sturfelt, G, Nived, O, van Vollenhoven, R, Ramos-Casals, M, Aranow, C, Mackay, M, Kalunian, K, Alarcón, G S, Fessler, B J, Ruiz-Irastorza, G, Petri, M, Lim, S, Kamen, D, Peschken, C, Farewell, V, Thompson, K, Theriault, C, and Merrill, J T

Published
2011
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41. SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus

Author

Hanly, J G, Urowitz, M B, Jackson, D, Bae, S C, Gordon, C, Wallace, D J, Clarke, A, Bernatsky, S, Vasudevan, A, Isenberg, D, Rahman, A, Sanchez-Guerrero, J, Romero-Diaz, J, Merrill, J T, Fortin, P R, Gladman, D D, Bruce, I N, Steinsson, K, Khamashta, M, Alarcón, G S, Fessler, B, Petri, M, Manzi, S, Nived, O, Sturfelt, G, Ramsey-Goldman, R, Dooley, M A, Aranow, C, Van Vollenhoven, R, Ramos-Casals, M, Zoma, A, Kalunian, K, and Farewell, V

Published
2011
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47. Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus

Author

Hanly, J G, Urowitz, M B, Su, L, Bae, S C, Gordon, C, Wallace, D J, Clarke, A, Bernatsky, S, Isenberg, D, Rahman, A, Alarcón, G S, Gladman, D D, Fortin, P R, Sanchez-Guerrero, J, Romero-Diaz, J, Merrill, J T, Ginzler, E, Bruce, I N, Steinsson, K, Khamashta, M, Petri, M, Manzi, S, Dooley, M A, Ramsey-Goldman, R, Van Vollenhoven, R, Nived, O, Sturfelt, G, Aranow, C, Kalunian, K, Ramos-Casals, M, Zoma, A, Douglas, J, Thompson, K, and Farewell, V

Published
2010
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