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Supplementary Figure S6 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Supplementary Figure S5 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Supplementary Figure S3 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Supplementary Figure S4 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Supplementary Figure S10 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Supplementary Figure S7 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Supplementary Figure S9 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Significant caspase-8 activity has been found in normal and certain tumor cells, suggesting that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progression. In this article, we report that caspase-8 promotes cell motility. In particular, caspase-8 is required for the optimal activation of calpains, Rac, and lamellipodial assembly. This represents a novel nonapoptotic function of caspase-8 acting at the intersection of the caspase-8 and calpain proteolytic pathways to coordinate cell death versus cell motility signaling. (Cancer Res 2006; 66(8): 4273-8)

Supplementary Figure S8 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Supplementary Figure S2 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Supplementary Figure S1 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Supplementary Figure Legends S1-S10 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Significant caspase-8 activity has been found in normal and certain tumor cells, suggesting that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progression. In this article, we report that caspase-8 promotes cell motility. In particular, caspase-8 is required for the optimal activation of calpains, Rac, and lamellipodial assembly. This represents a novel nonapoptotic function of caspase-8 acting at the intersection of the caspase-8 and calpain proteolytic pathways to coordinate cell death versus cell motility signaling. (Cancer Res 2006; 66(8): 4273-8)