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1. Molecular taxonomy of myelodysplastic syndromes and its clinical implications

Author

Bernard, Elsa, Hasserjian, Robert P., Greenberg, Peter L., Arango Ossa, Juan E., Creignou, Maria, Tuechler, Heinz, Gutierrez-Abril, Jesus, Domenico, Dylan, Medina-Martinez, Juan S., Levine, Max, Liosis, Konstantinos, Farnoud, Noushin, Sirenko, Maria, Jädersten, Martin, Germing, Ulrich, Sanz, Guillermo, van de Loosdrecht, Arjan A., Nannya, Yasuhito, Kosmider, Olivier, Follo, Matilde Y., Thol, Felicitas, Zamora, Lurdes, Pinheiro, Ronald F., Pellagatti, Andrea, Elias, Harold K., Haase, Detlef, Ganster, Christina, Ades, Lionel, Tobiasson, Magnus, Palomo, Laura, Della Porta, Matteo Giovanni, Fenaux, Pierre, Belickova, Monika, Savona, Michael R., Klimek, Virginia M., Santos, Fabio P. S., Boultwood, Jacqueline, Kotsianidis, Ioannis, Santini, Valeria, Solé, Francesc, Platzbecker, Uwe, Heuser, Michael, Valent, Peter, Finelli, Carlo, Voso, Maria Teresa, Shih, Lee-Yung, Fontenay, Michaela, Jansen, Joop H., Cervera, José, Gattermann, Norbert, Ebert, Benjamin L., Bejar, Rafael, Malcovati, Luca, Ogawa, Seishi, Cazzola, Mario, Hellström-Lindberg, Eva, and Papaemmanuil, Elli

Published
2024
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2. The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts

Author

Choi, In Young, Ling, Jonathan P., Zhang, Jian, Helmenstine, Eric, Walter, Wencke, Tsakiroglou, Panagiotis, Bergman, Riley E., Philippe, Céline, Manley, James L., Rouault-Pierre, Kevin, Li, Bing, Wiseman, Daniel H., Batta, Kiran, Ouseph, Madhu, Bernard, Elsa, Dubner, Benjamin, Li, Xiao, Haferlach, Torsten, Koget, Anna, Fazal, Salman, Jain, Tania, Gocke, Christopher D., DeZern, Amy E., and Dalton, William Brian

Published
2024
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3. Embracing cancer complexity: Hallmarks of systemic disease

Author

Swanton, Charles, Bernard, Elsa, Abbosh, Chris, André, Fabrice, Auwerx, Johan, Balmain, Allan, Bar-Sagi, Dafna, Bernards, René, Bullman, Susan, DeGregori, James, Elliott, Catherine, Erez, Ayelet, Evan, Gerard, Febbraio, Mark A., Hidalgo, Andrés, Jamal-Hanjani, Mariam, Joyce, Johanna A., Kaiser, Matthew, Lamia, Katja, Locasale, Jason W., Loi, Sherene, Malanchi, Ilaria, Merad, Miriam, Musgrave, Kathryn, Patel, Ketan J., Quezada, Sergio, Wargo, Jennifer A., Weeraratna, Ashani, White, Eileen, Winkler, Frank, Wood, John N., Vousden, Karen H., and Hanahan, Douglas

Published
2024
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6. Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms

Author

Nannya, Yasuhito, Tobiasson, Magnus, Sato, Shinya, Bernard, Elsa, Ohtake, Shigeki, Takeda, June, Creignou, Maria, Zhao, Lanying, Kusakabe, Manabu, Shibata, Yuhei, Nakamura, Nobuhiko, Watanabe, Mizuki, Hiramoto, Nobuhiro, Shiozawa, Yusuke, Shiraishi, Yuichi, Tanaka, Hiroko, Yoshida, Kenichi, Kakiuchi, Nobuyuki, Makishima, Hideki, Nakagawa, Masahiro, Usuki, Kensuke, Watanabe, Mitsumasa, Imada, Kazunori, Handa, Hiroshi, Taguchi, Masataka, Kiguchi, Toru, Ohyashiki, Kazuma, Ishikawa, Takayuki, Takaori-Kondo, Akifumi, Tsurumi, Hisashi, Kasahara, Senji, Chiba, Shigeru, Naoe, Tomoki, Miyano, Satoru, Papaemanuil, Elli, Miyazaki, Yasushi, Hellström-Lindberg, Eva, and Ogawa, Seishi

Published
2023
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7. Cancer therapy shapes the fitness landscape of clonal hematopoiesis.

Author

Bolton, Kelly, Ptashkin, Ryan, Gao, Teng, Braunstein, Lior, Devlin, Sean, Kelly, Daniel, Patel, Minal, Berthon, Antonin, Syed, Aijazuddin, Yabe, Mariko, Coombs, Catherine, Caltabellotta, Nicole, Walsh, Mike, Offit, Kenneth, Stadler, Zsofia, Mandelker, Diana, Schulman, Jessica, Patel, Akshar, Philip, John, Bernard, Elsa, Gundem, Gunes, Ossa, Juan, Levine, Max, Martinez, Juan, Farnoud, Noushin, Glodzik, Dominik, Li, Sonya, Robson, Mark, Lee, Choonsik, Pharoah, Paul, Stopsack, Konrad, Spitzer, Barbara, Mantha, Simon, Fagin, James, Boucai, Laura, Gibson, Christopher, Ebert, Benjamin, Young, Andrew, Druley, Todd, Takahashi, Koichi, Gillis, Nancy, Ball, Markus, Padron, Eric, Hyman, David, Baselga, Jose, Norton, Larry, Gardos, Stuart, Klimek, Virginia, Scher, Howard, Bajorin, Dean, Paraiso, Eder, Benayed, Ryma, Arcila, Maria, Ladanyi, Marc, Solit, David, Berger, Michael, Tallman, Martin, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Diaz, Luis, Levine, Ross, Morton, Lindsay, Zehir, Ahmet, and Papaemmanuil, Elli

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Cell Transformation, Neoplastic, Child, Child, Preschool, Clonal Evolution, Clonal Hematopoiesis, Cohort Studies, Female, Genetic Fitness, Humans, Infant, Infant, Newborn, Leukemia, Myeloid, Male, Middle Aged, Models, Biological, Mutation, Neoplasms, Neoplasms, Second Primary, Selection, Genetic, Young Adult
Abstract

Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of clonal hematopoiesis (CH) and the development of therapy-related myeloid neoplasms (tMNs). We find that mutations are selected differentially based on exposures. Mutations in ASXL1 are enriched in current or former smokers, whereas cancer therapy with radiation, platinum and topoisomerase II inhibitors preferentially selects for mutations in DNA damage response genes (TP53, PPM1D, CHEK2). Sequential sampling provides definitive evidence that DNA damage response clones outcompete other clones when exposed to certain therapies. Among cases in which CH was previously detected, the CH mutation was present at tMN diagnosis. We identify the molecular characteristics of CH that increase risk of tMN. The increasing implementation of clinical sequencing at diagnosis provides an opportunity to identify patients at risk of tMN for prevention strategies.

Published
2020

8. Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Author

Bernard, Elsa, Nannya, Yasuhito, Hasserjian, Robert P, Devlin, Sean M, Tuechler, Heinz, Medina-Martinez, Juan S, Yoshizato, Tetsuichi, Shiozawa, Yusuke, Saiki, Ryunosuke, Malcovati, Luca, Levine, Max F, Arango, Juan E, Zhou, Yangyu, Solé, Francesc, Cargo, Catherine A, Haase, Detlef, Creignou, Maria, Germing, Ulrich, Zhang, Yanming, Gundem, Gunes, Sarian, Araxe, van de Loosdrecht, Arjan A, Jädersten, Martin, Tobiasson, Magnus, Kosmider, Olivier, Follo, Matilde Y, Thol, Felicitas, Pinheiro, Ronald F, Santini, Valeria, Kotsianidis, Ioannis, Boultwood, Jacqueline, Santos, Fabio PS, Schanz, Julie, Kasahara, Senji, Ishikawa, Takayuki, Tsurumi, Hisashi, Takaori-Kondo, Akifumi, Kiguchi, Toru, Polprasert, Chantana, Bennett, John M, Klimek, Virginia M, Savona, Michael R, Belickova, Monika, Ganster, Christina, Palomo, Laura, Sanz, Guillermo, Ades, Lionel, Della Porta, Matteo Giovanni, Elias, Harold K, Smith, Alexandra G, Werner, Yesenia, Patel, Minal, Viale, Agnès, Vanness, Katelynd, Neuberg, Donna S, Stevenson, Kristen E, Menghrajani, Kamal, Bolton, Kelly L, Fenaux, Pierre, Pellagatti, Andrea, Platzbecker, Uwe, Heuser, Michael, Valent, Peter, Chiba, Shigeru, Miyazaki, Yasushi, Finelli, Carlo, Voso, Maria Teresa, Shih, Lee-Yung, Fontenay, Michaela, Jansen, Joop H, Cervera, José, Atsuta, Yoshiko, Gattermann, Norbert, Ebert, Benjamin L, Bejar, Rafael, Greenberg, Peter L, Cazzola, Mario, Hellström-Lindberg, Eva, Ogawa, Seishi, and Papaemmanuil, Elli

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Hematology, Stem Cell Research, Cancer, Clinical Research, Rare Diseases, Genetics, 2.1 Biological and endogenous factors, Aetiology, Alleles, Cohort Studies, DNA Copy Number Variations, DNA Mutational Analysis, Female, Gene Frequency, Genomic Instability, Humans, Loss of Heterozygosity, Male, Mutation, Myelodysplastic Syndromes, Phenotype, Prognosis, Survival Analysis, Treatment Outcome, Tumor Suppressor Protein p53, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

Tumor protein p53 (TP53) is the most frequently mutated gene in cancer1,2. In patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease3,4, rapid transformation to acute myeloid leukemia (AML)5, resistance to conventional therapies6-8 and dismal outcomes9. Consistent with the tumor-suppressive role of TP53, patients harbor both mono- and biallelic mutations10. However, the biological and clinical implications of TP53 allelic state have not been fully investigated in MDS or any other cancer type. We analyzed 3,324 patients with MDS for TP53 mutations and allelic imbalances and delineated two subsets of patients with distinct phenotypes and outcomes. One-third of TP53-mutated patients had monoallelic mutations whereas two-thirds had multiple hits (multi-hit) consistent with biallelic targeting. Established associations with complex karyotype, few co-occurring mutations, high-risk presentation and poor outcomes were specific to multi-hit patients only. TP53 multi-hit state predicted risk of death and leukemic transformation independently of the Revised International Prognostic Scoring System (IPSS-R)11. Surprisingly, monoallelic patients did not differ from TP53 wild-type patients in outcomes and response to therapy. This study shows that consideration of TP53 allelic state is critical for diagnostic and prognostic precision in MDS as well as in future correlative studies of treatment response.

Published
2020

9. “Randomized phase II study of azacitidine ± lenalidomide in higher-risk myelodysplastic syndromes and acute myeloid leukemia with a karyotype including Del(5q)”

Author

Rasmussen, Bengt, Göhring, Gudrun, Bernard, Elsa, Nilsson, Lars, Tobiasson, Magnus, Jädersten, Martin, Garelius, Hege, Dybedal, Ingunn, Grønbaek, Kirsten, Ejerblad, Elisabeth, Lorenz, Fryderyk, Flogegård, Max, Marcher, Claus Werenberg, Öster Fernström, Annette, Cavelier, Lucia, Papaemmanuil, Elli, Ebeling, Freja, Kittang, Astrid Olsnes, Nørgaard, Jan Maxwell, Saft, Leonie, Möllgård, Lars, and Hellström-Lindberg, Eva

Published
2022
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10. Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs

Author

Asimomitis, Georgios, Deslauriers, André G., Kotini, Andriana G., Bernard, Elsa, Esposito, Davide, Olszewska, Malgorzata, Spyrou, Nikolaos, Arango Ossa, Juan, Mortera-Blanco, Teresa, Koche, Richard, Nannya, Yasuhito, Malcovati, Luca, Ogawa, Seishi, Cazzola, Mario, Aaronson, Stuart A., Hellström-Lindberg, Eva, Papaemmanuil, Elli, and Papapetrou, Eirini P.

Published
2022
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11. Unified classification and risk-stratification in Acute Myeloid Leukemia

Author

Tazi, Yanis, Arango-Ossa, Juan E., Zhou, Yangyu, Bernard, Elsa, Thomas, Ian, Gilkes, Amanda, Freeman, Sylvie, Pradat, Yoann, Johnson, Sean J., Hills, Robert, Dillon, Richard, Levine, Max F., Leongamornlert, Daniel, Butler, Adam, Ganser, Arnold, Bullinger, Lars, Döhner, Konstanze, Ottmann, Oliver, Adams, Richard, Döhner, Hartmut, Campbell, Peter J., Burnett, Alan K., Dennis, Michael, Russell, Nigel H., Devlin, Sean M., Huntly, Brian J. P., and Papaemmanuil, Elli

Published
2022
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12. Molecular and clinical presentation of UBA1-mutated myelodysplastic syndromes

Author

Sirenko, Maria, primary, Bernard, Elsa, additional, Creignou, Maria, additional, Domenico, Dylan, additional, Farina, Andrea, additional, Arango Ossa, Juan Esteban, additional, Kosmider, Olivier, additional, Hasserjian, Robert P, additional, Jädersten, Martin, additional, Germing, Ulrich, additional, Sanz, Guillermo F., additional, van de Loosdrecht, Arjan A., additional, Gurnari, Carmelo, additional, Follo, Matilde Y, additional, Thol, Felicitas R., additional, Zamora, Lurdes, additional, Pellagatti, Andrea, additional, Elias, Harold Kunal, additional, Haase, Detlef Thomas, additional, Sander, Birgitta, additional, Orna, Elisa, additional, Zoldan, Katharina, additional, Eder, Lea Naomi, additional, Sperr, Wolfgang R, additional, Thalhammer, Renate, additional, Ganster, Christina, additional, Adès, Lionel, additional, Tobiasson, Magnus, additional, Palomo, Laura, additional, Della Porta, Matteo Giovanni, additional, Huberman, Kety H, additional, Fenaux, Pierre, additional, Belickova, Monika, additional, Savona, Michael R., additional, Klimek, Virginia, additional, Santos, Fabio P S, additional, Boultwood, Jacqueline, additional, Kotsianidis, Ioannis, additional, Santini, Valeria, additional, Sole, Francesc, additional, Platzbecker, Uwe, additional, Heuser, Michael, additional, Valent, Peter, additional, Finelli, Carlo, additional, Voso, Maria Teresa, additional, Shih, Lee Yung, additional, Ogawa, Seishi, additional, Fontenay, Michaela, additional, Jansen, Joop H, additional, Cervera, José, additional, Ebert, Benjamin L, additional, Bejar, Rafael, additional, Greenberg, Peter L., additional, Gattermann, Norbert, additional, Malcovati, Luca, additional, Cazzola, Mario, additional, Beck, David B., additional, Hellstrom-Lindberg, Eva S, additional, Papaemmanuil, Elli, additional, and Pinheiro, Ronald Feitosa, additional

Published
2024
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14. Liquid Biopsies for Circulating Tumor DNA Detection May Reveal Occult Hematologic Malignancies in Patients With Solid Tumors

Author

Aldea, Mihaela, Tagliamento, Marco, Bayle, Arnaud, Vasseur, Damien, Vergé, Véronique, Marinello, Arianna, Danlos, François-Xavier, Blanc-Durand, Felix, Bernard, Elsa, Cerbone, Luigi, Mosele, Maria Fernanda, Renneville, Aline, Hadoux, Julien, Loriot, Yohann, Sakkal, Madona, Vozy, Aurore, Sarkozy, Clementine, Smolenschi, Cristina, Nicotra, Claudio, Martin-Romano, Patricia, Boccon-Gibod, Clementine, Habza, Wafikaamira, Lazarovici, Julien, Ponce, Santiago, Hollebecque, Antoine, Marzac, Christophe, Lacroix, Ludovic, Barlesi, Fabrice, André, Fabrice, Besse, Benjamin, Rouleau, Etienne, Italiano, Antoine, and Micol, Jean-Baptiste

Published
2023
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15. A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates.

Author

Plouhinec, Jean-Louis, Medina-Ruiz, Sofía, Borday, Caroline, Bernard, Elsa, Vert, Jean-Philippe, Eisen, Michael B, Harland, Richard M, and Monsoro-Burq, Anne H

Subjects
Neurons, Stem Cells, Ectoderm, Neural Crest, Animals, Xenopus laevis, Humans, Neoplasms, Microdissection, Cluster Analysis, Gene Expression Profiling, Gene Expression Regulation, Developmental, Algorithms, Principal Component Analysis, Time Factors, Internet, Databases, Genetic, Wnt Proteins, Gene Regulatory Networks, Neurulation, Gastrulation, Transcriptome, Gene Ontology, Gene Expression Regulation, Developmental, Databases, Genetic, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Developmental Biology
Abstract

During vertebrate neurulation, the embryonic ectoderm is patterned into lineage progenitors for neural plate, neural crest, placodes and epidermis. Here, we use Xenopus laevis embryos to analyze the spatial and temporal transcriptome of distinct ectodermal domains in the course of neurulation, during the establishment of cell lineages. In order to define the transcriptome of small groups of cells from a single germ layer and to retain spatial information, dorsal and ventral ectoderm was subdivided along the anterior-posterior and medial-lateral axes by microdissections. Principal component analysis on the transcriptomes of these ectoderm fragments primarily identifies embryonic axes and temporal dynamics. This provides a genetic code to define positional information of any ectoderm sample along the anterior-posterior and dorsal-ventral axes directly from its transcriptome. In parallel, we use nonnegative matrix factorization to predict enhanced gene expression maps onto early and mid-neurula embryos, and specific signatures for each ectoderm area. The clustering of spatial and temporal datasets allowed detection of multiple biologically relevant groups (e.g., Wnt signaling, neural crest development, sensory placode specification, ciliogenesis, germ layer specification). We provide an interactive network interface, EctoMap, for exploring synexpression relationships among genes expressed in the neurula, and suggest several strategies to use this comprehensive dataset to address questions in developmental biology as well as stem cell or cancer research.

Published
2017

16. Modulation of IL-6/STAT3 signaling axis in CD4+FOXP3− T cells represents a potential antitumor mechanism of azacitidine

Author

Lamprianidou, Eleftheria, Kordella, Chryssoula, Kazachenka, Anastasiya, Zoulia, Emmanouela, Bernard, Elsa, Filia, Anastasia, Laidou, Stamatia, Garantziotis, Panayiotis, Vassilakopoulos, Theodoros P., Papageorgiou, Sotirios G., Pappa, Vassiliki, Galanopoulos, Athanasios G., Viniou, Nora, Nakou, Evangelia, Kalafati, Lydia, Chatzidimitriou, Anastasia, Kassiotis, George, Papaemmanuil, Elli, Mitroulis, Ioannis, and Kotsianidis, Ioannis

Published
2021
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17. Early transfusion patterns improve the Molecular International Prognostic Scoring System (IPSS-M) prediction in myelodysplastic syndromes

Author

Creignou, Maria, Bernard, Elsa, Gasparini, Alessandro, Tranberg, Anna, Todisco, Gabriele, Moura, Pedro Luis, Ejerblad, Elisabeth, Nilsson, Lars, Garelius, Hege, Antunovic, Petar, Lorenz, Fryderyk, Rasmussen, Bengt, Walldin, Gunilla, Mortera-Blanco, Teresa, Jansson, Monika, Tobiasson, Magnus, Elena, Chiara, Ferrari, Jacqueline, Galli, Anna, Pozzi, Sara, Malcovati, Luca, Edgren, Gustaf, Crowther, Michael J., Jaedersten, Martin, Papaemmanuil, Elli, Hellstroem-Lindberg, Eva, Creignou, Maria, Bernard, Elsa, Gasparini, Alessandro, Tranberg, Anna, Todisco, Gabriele, Moura, Pedro Luis, Ejerblad, Elisabeth, Nilsson, Lars, Garelius, Hege, Antunovic, Petar, Lorenz, Fryderyk, Rasmussen, Bengt, Walldin, Gunilla, Mortera-Blanco, Teresa, Jansson, Monika, Tobiasson, Magnus, Elena, Chiara, Ferrari, Jacqueline, Galli, Anna, Pozzi, Sara, Malcovati, Luca, Edgren, Gustaf, Crowther, Michael J., Jaedersten, Martin, Papaemmanuil, Elli, and Hellstroem-Lindberg, Eva

Abstract

Background The Molecular International Prognostic Scoring System (IPSS-M) is the new gold standard for diagnostic outcome prediction in patients with myelodysplastic syndromes (MDS). This study was designed to assess the additive prognostic impact of dynamic transfusion parameters during early follow-up. Methods We retrieved complete transfusion data from 677 adult Swedish MDS patients included in the IPSS-M cohort. Time-dependent erythrocyte transfusion dependency (E-TD) was added to IPSS-M features and analyzed regarding overall survival and leukemic transformation (acute myeloid leukemia). A multistate Markov model was applied to assess the prognostic value of early changes in transfusion patterns. Results Specific clinical and genetic features were predicted for diagnostic and time-dependent transfusion patterns. Importantly, transfusion state both at diagnosis and within the first year strongly predicts outcomes in both lower (LR) and higher-risk (HR) MDSs. In multivariable analysis, 8-month landmark E-TD predicted shorter survival independently of IPSS-M (p < 0.001). A predictive model based on IPSS-M and 8-month landmark E-TD performed significantly better than a model including only IPSS-M. Similar trends were observed in an independent validation cohort (n = 218). Early transfusion patterns impacted both future transfusion requirements and outcomes in a multistate Markov model. Conclusion The transfusion requirement is a robust and available clinical parameter incorporating the effects of first-line management. In MDS, it provides dynamic risk information independently of diagnostic IPSS-M and, in particular, clinical guidance to LR MDS patients eligible for potentially curative therapeutic intervention., Funding Agencies|Edward P. Evans Foundation

Published
2024
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18. Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

Author

Gao, Teng, Ptashkin, Ryan, Bolton, Kelly L., Sirenko, Maria, Fong, Christopher, Spitzer, Barbara, Menghrajani, Kamal, Ossa, Juan E. Arango, Zhou, Yangyu, Bernard, Elsa, Levine, Max, Martinez, Juan S. Medina, Zhang, Yanming, Franch-Expósito, Sebastià, Patel, Minal, Braunstein, Lior Z., Kelly, Daniel, Yabe, Mariko, Benayed, Ryma, Caltabellotta, Nicole M., Philip, John, Paraiso, Ederlinda, Mantha, Simon, Solit, David B., Diaz, Jr, Luis A., Berger, Michael F., Klimek, Virginia, Levine, Ross L., Zehir, Ahmet, Devlin, Sean M., and Papaemmanuil, Elli

Published
2021
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19. Mutational Profile and Dynamics of PPM1D-Mutant Clones in the Spectrum of Myeloid Disorders

Author

Pegliasco, Jean, primary, Fandrei, David, additional, Pasquier, Florence, additional, Ibrahim, Nathalie, additional, Kfoury, Maria, additional, Imbert-De-Tremiolles, Guillemette, additional, Lizziek, Nourhan, additional, Berthon, Céline, additional, Heiblig, Mael, additional, Lebon, Delphine, additional, Marcais, Ambroise, additional, Meunier, Mathieu, additional, Aljijakli, Ahmad, additional, Lemasle, Emilie, additional, Chantepie, Sylvain, additional, Pautas, Cécile, additional, Dumas, Pierre-Yves, additional, Haiat, Stephanie, additional, Quivoron, Cyril, additional, antony-Debre, Ileana, additional, Cotteret, Sophie, additional, Itzykson, Raphael, additional, Dombret, Hervé, additional, Duployez, Nicolas, additional, Droin, Nathalie, additional, Marzac, Christophe, additional, Bernard, Elsa, additional, and Micol, Jean-Baptiste, additional

Published
2023
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20. Supplementary Figure S7 from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts

Author

Todisco, Gabriele, primary, Creignou, Maria, primary, Bernard, Elsa, primary, Björklund, Ann-Charlotte, primary, Moura, Pedro Luis, primary, Tesi, Bianca, primary, Mortera-Blanco, Teresa, primary, Sander, Birgitta, primary, Jansson, Monika, primary, Walldin, Gunilla, primary, Barbosa, Indira, primary, Reinsbach, Susanne E., primary, Hofman, Isabel Juliana, primary, Nilsson, Christer, primary, Yoshizato, Tetsuichi, primary, Dimitriou, Marios, primary, Chang, David, primary, Olafsdottir, Svannildur, primary, Venckute Larsson, Sigita, primary, Tobiasson, Magnus, primary, Malcovati, Luca, primary, Woll, Petter, primary, Jacobsen, Sten Eirik W., primary, Papaemmanuil, Elli, primary, and Hellström-Lindberg, Eva, primary

Published
2023
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21. Supplementary Results S1 from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts

Author

Todisco, Gabriele, primary, Creignou, Maria, primary, Bernard, Elsa, primary, Björklund, Ann-Charlotte, primary, Moura, Pedro Luis, primary, Tesi, Bianca, primary, Mortera-Blanco, Teresa, primary, Sander, Birgitta, primary, Jansson, Monika, primary, Walldin, Gunilla, primary, Barbosa, Indira, primary, Reinsbach, Susanne E., primary, Hofman, Isabel Juliana, primary, Nilsson, Christer, primary, Yoshizato, Tetsuichi, primary, Dimitriou, Marios, primary, Chang, David, primary, Olafsdottir, Svannildur, primary, Venckute Larsson, Sigita, primary, Tobiasson, Magnus, primary, Malcovati, Luca, primary, Woll, Petter, primary, Jacobsen, Sten Eirik W., primary, Papaemmanuil, Elli, primary, and Hellström-Lindberg, Eva, primary

Published
2023
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22. Supplementary Table S1 from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts

Author

Todisco, Gabriele, primary, Creignou, Maria, primary, Bernard, Elsa, primary, Björklund, Ann-Charlotte, primary, Moura, Pedro Luis, primary, Tesi, Bianca, primary, Mortera-Blanco, Teresa, primary, Sander, Birgitta, primary, Jansson, Monika, primary, Walldin, Gunilla, primary, Barbosa, Indira, primary, Reinsbach, Susanne E., primary, Hofman, Isabel Juliana, primary, Nilsson, Christer, primary, Yoshizato, Tetsuichi, primary, Dimitriou, Marios, primary, Chang, David, primary, Olafsdottir, Svannildur, primary, Venckute Larsson, Sigita, primary, Tobiasson, Magnus, primary, Malcovati, Luca, primary, Woll, Petter, primary, Jacobsen, Sten Eirik W., primary, Papaemmanuil, Elli, primary, and Hellström-Lindberg, Eva, primary

Published
2023
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23. Data from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts

Author

Todisco, Gabriele, primary, Creignou, Maria, primary, Bernard, Elsa, primary, Björklund, Ann-Charlotte, primary, Moura, Pedro Luis, primary, Tesi, Bianca, primary, Mortera-Blanco, Teresa, primary, Sander, Birgitta, primary, Jansson, Monika, primary, Walldin, Gunilla, primary, Barbosa, Indira, primary, Reinsbach, Susanne E., primary, Hofman, Isabel Juliana, primary, Nilsson, Christer, primary, Yoshizato, Tetsuichi, primary, Dimitriou, Marios, primary, Chang, David, primary, Olafsdottir, Svannildur, primary, Venckute Larsson, Sigita, primary, Tobiasson, Magnus, primary, Malcovati, Luca, primary, Woll, Petter, primary, Jacobsen, Sten Eirik W., primary, Papaemmanuil, Elli, primary, and Hellström-Lindberg, Eva, primary

Published
2023
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25. Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts

Author

Todisco, Gabriele, primary, Creignou, Maria, additional, Bernard, Elsa, additional, Björklund, Ann-Charlotte, additional, Moura, Pedro Luis, additional, Tesi, Bianca, additional, Mortera-Blanco, Teresa, additional, Sander, Birgitta, additional, Jansson, Monika, additional, Walldin, Gunilla, additional, Barbosa, Indira, additional, Reinsbach, Susanne E., additional, Hofman, Isabel Juliana, additional, Nilsson, Christer, additional, Yoshizato, Tetsuichi, additional, Dimitriou, Marios, additional, Chang, David, additional, Olafsdottir, Svannildur, additional, Venckute Larsson, Sigita, additional, Tobiasson, Magnus, additional, Malcovati, Luca, additional, Woll, Petter, additional, Jacobsen, Sten Eirik W., additional, Papaemmanuil, Elli, additional, and Hellström-Lindberg, Eva, additional

Published
2023
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26. Supplementary Tables 1-6 from Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Author

Kotini, Andriana G., primary, Carcamo, Saul, primary, Cruz-Rodriguez, Nataly, primary, Olszewska, Malgorzata, primary, Wang, Tiansu, primary, Demircioglu, Deniz, primary, Chang, Chan-Jung, primary, Bernard, Elsa, primary, Chao, Mark P., primary, Majeti, Ravindra, primary, Luo, Hanzhi, primary, Kharas, Michael G., primary, Hasson, Dan, primary, and Papapetrou, Eirini P., primary

Published
2023
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27. Data from Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Author

Kotini, Andriana G., primary, Carcamo, Saul, primary, Cruz-Rodriguez, Nataly, primary, Olszewska, Malgorzata, primary, Wang, Tiansu, primary, Demircioglu, Deniz, primary, Chang, Chan-Jung, primary, Bernard, Elsa, primary, Chao, Mark P., primary, Majeti, Ravindra, primary, Luo, Hanzhi, primary, Kharas, Michael G., primary, Hasson, Dan, primary, and Papapetrou, Eirini P., primary

Published
2023
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28. Supplementary Figures 1-8 from Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Author

Kotini, Andriana G., primary, Carcamo, Saul, primary, Cruz-Rodriguez, Nataly, primary, Olszewska, Malgorzata, primary, Wang, Tiansu, primary, Demircioglu, Deniz, primary, Chang, Chan-Jung, primary, Bernard, Elsa, primary, Chao, Mark P., primary, Majeti, Ravindra, primary, Luo, Hanzhi, primary, Kharas, Michael G., primary, Hasson, Dan, primary, and Papapetrou, Eirini P., primary

Published
2023
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29. Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelomonocytic Leukemia: Clinical and Molecular Genetic Prognostic Factors in a Nordic Population

Author

Wedge, Eileen, Hansen, Jakob Werner, Dybedal, Ingunn, Creignou, Maria, Ejerblad, Elisabeth, Lorenz, Fryderyk, Werlenius, Olle, Ungerstedt, Johanna, Holm, Mette Skov, Nilsson, Lars, Kittang, Astrid Olsnes, Antunovic, Peter, Rohon, Peter, Andersen, Mette Klarskov, Papaemmanuil, Elli, Bernard, Elsa, Jädersten, Martin, Hellström-Lindberg, Eva, Grønbæk, Kirsten, Ljungman, Per, and Friis, Lone Smidstrup

Published
2021
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31. Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Author

Kotini, Andriana G., primary, Carcamo, Saul, additional, Cruz-Rodriguez, Nataly, additional, Olszewska, Malgorzata, additional, Wang, Tiansu, additional, Demircioglu, Deniz, additional, Chang, Chan-Jung, additional, Bernard, Elsa, additional, Chao, Mark P., additional, Majeti, Ravindra, additional, Luo, Hanzhi, additional, Kharas, Michael G., additional, Hasson, Dan, additional, and Papapetrou, Eirini P., additional

Published
2023
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32. The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts

Author

Dalton, William, primary, Choi, InYoung, additional, Ling, Jonathan, additional, Zhang, Jian, additional, Helmenstine, Eric, additional, Walter, Wencke, additional, Bergman, Riley, additional, Philippe, Céline, additional, Manley, James, additional, Rouault-Pierre, Kevin, additional, Li, Bing, additional, Wiseman, Daniel, additional, Ouseph, Madhu, additional, Bernard, Elsa, additional, Li, Xiao, additional, Haferlach, Torsten, additional, Fazal, Salman, additional, Jain, Tania, additional, Gocke, Christopher, additional, and DeZern, Amy, additional

Published
2023
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33. Supplementary Figures S1-S11 from ZBTB33 Is Mutated in Clonal Hematopoiesis and Myelodysplastic Syndromes and Impacts RNA Splicing

Author

Beauchamp, Ellen M., primary, Leventhal, Matthew, primary, Bernard, Elsa, primary, Hoppe, Emma R., primary, Todisco, Gabriele, primary, Creignou, Maria, primary, Gallì, Anna, primary, Castellano, Cecilia A., primary, McConkey, Marie, primary, Tarun, Akansha, primary, Wong, Waihay, primary, Schenone, Monica, primary, Stanclift, Caroline, primary, Tanenbaum, Benjamin, primary, Malolepsza, Edyta, primary, Nilsson, Björn, primary, Bick, Alexander G., primary, Weinstock, Joshua S., primary, Miller, Mendy, primary, Niroula, Abhishek, primary, Dunford, Andrew, primary, Taylor-Weiner, Amaro, primary, Wood, Timothy, primary, Barbera, Alex, primary, Anand, Shankara, primary, Psaty, Bruce M., primary, Desai, Pinkal, primary, Cho, Michael H., primary, Johnson, Andrew D., primary, Loos, Ruth, primary, MacArthur, Daniel G., primary, Lek, Monkol, primary, Neuberg, Donna S., primary, Lage, Kasper, primary, Carr, Steven A., primary, Hellstrom-Lindberg, Eva, primary, Malcovati, Luca, primary, Papaemmanuil, Elli, primary, Stewart, Chip, primary, Getz, Gad, primary, Bradley, Robert K., primary, Jaiswal, Siddhartha, primary, and Ebert, Benjamin L., primary

Published
2023
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34. Data from ZBTB33 Is Mutated in Clonal Hematopoiesis and Myelodysplastic Syndromes and Impacts RNA Splicing

Author

Beauchamp, Ellen M., primary, Leventhal, Matthew, primary, Bernard, Elsa, primary, Hoppe, Emma R., primary, Todisco, Gabriele, primary, Creignou, Maria, primary, Gallì, Anna, primary, Castellano, Cecilia A., primary, McConkey, Marie, primary, Tarun, Akansha, primary, Wong, Waihay, primary, Schenone, Monica, primary, Stanclift, Caroline, primary, Tanenbaum, Benjamin, primary, Malolepsza, Edyta, primary, Nilsson, Björn, primary, Bick, Alexander G., primary, Weinstock, Joshua S., primary, Miller, Mendy, primary, Niroula, Abhishek, primary, Dunford, Andrew, primary, Taylor-Weiner, Amaro, primary, Wood, Timothy, primary, Barbera, Alex, primary, Anand, Shankara, primary, Psaty, Bruce M., primary, Desai, Pinkal, primary, Cho, Michael H., primary, Johnson, Andrew D., primary, Loos, Ruth, primary, MacArthur, Daniel G., primary, Lek, Monkol, primary, Neuberg, Donna S., primary, Lage, Kasper, primary, Carr, Steven A., primary, Hellstrom-Lindberg, Eva, primary, Malcovati, Luca, primary, Papaemmanuil, Elli, primary, Stewart, Chip, primary, Getz, Gad, primary, Bradley, Robert K., primary, Jaiswal, Siddhartha, primary, and Ebert, Benjamin L., primary

Published
2023
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35. Supplementary Tables S1-S19 from ZBTB33 Is Mutated in Clonal Hematopoiesis and Myelodysplastic Syndromes and Impacts RNA Splicing

Author

Beauchamp, Ellen M., primary, Leventhal, Matthew, primary, Bernard, Elsa, primary, Hoppe, Emma R., primary, Todisco, Gabriele, primary, Creignou, Maria, primary, Gallì, Anna, primary, Castellano, Cecilia A., primary, McConkey, Marie, primary, Tarun, Akansha, primary, Wong, Waihay, primary, Schenone, Monica, primary, Stanclift, Caroline, primary, Tanenbaum, Benjamin, primary, Malolepsza, Edyta, primary, Nilsson, Björn, primary, Bick, Alexander G., primary, Weinstock, Joshua S., primary, Miller, Mendy, primary, Niroula, Abhishek, primary, Dunford, Andrew, primary, Taylor-Weiner, Amaro, primary, Wood, Timothy, primary, Barbera, Alex, primary, Anand, Shankara, primary, Psaty, Bruce M., primary, Desai, Pinkal, primary, Cho, Michael H., primary, Johnson, Andrew D., primary, Loos, Ruth, primary, MacArthur, Daniel G., primary, Lek, Monkol, primary, Neuberg, Donna S., primary, Lage, Kasper, primary, Carr, Steven A., primary, Hellstrom-Lindberg, Eva, primary, Malcovati, Luca, primary, Papaemmanuil, Elli, primary, Stewart, Chip, primary, Getz, Gad, primary, Bradley, Robert K., primary, Jaiswal, Siddhartha, primary, and Ebert, Benjamin L., primary

Published
2023
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36. Abstract 6168: Implementation and adoption of a web tool to support precision diagnostic and treatment decisions for patient with myelodysplastic syndromes

Author

Bernard, Elsa, primary, Ossa, Juan E. Arango, additional, Tuechler, Heinz, additional, Greenberg, Peter L., additional, Hasserjian, Robert P., additional, Nannya, Yasuhito, additional, Devlin, Sean M., additional, Creignou, Maria, additional, Pinel, Philippe, additional, Monier, Lily, additional, Medina-Martinez, Juan S., additional, Domenico, Dylan, additional, Jädersten, Martin, additional, Germing, Ulrich, additional, Sanz, Guillermo, additional, van de Loosdrecht, Arjan A., additional, Kosmider, Olivier, additional, Follo, Matilde Y., additional, Thol, Felicitas, additional, Zamora, Lurdes, additional, Pinheiro, Ronald F., additional, Pellagatti, Andrea, additional, Haase, Detlef, additional, Fenaux, Pierre, additional, Belickova, Monika, additional, Savona, Michael R., additional, Klimek, Virginia M., additional, Santos, Fabio P., additional, Boultwood, Jacqueline, additional, Kotsianidis, Ioannis, additional, Santini, Valeria, additional, Solé, Francesc, additional, Platzbecker, Uwe, additional, Heuser, Michael, additional, Valent, Peter, additional, Ohyashiki, Kazuma, additional, Finelli, Carlo, additional, Voso, Maria Teresa, additional, Shih, Lee-Yung, additional, Fontenay, Michaela, additional, Jansen, Joop H., additional, Cervera, José, additional, Gattermann, Norbert, additional, Ebert, Benjamin L., additional, Bejar, Rafael, additional, Malcovati, Luca, additional, Cazzola, Mario, additional, Ogawa, Seishi, additional, Hellström-Lindberg, Eva, additional, and Papaemmanuil, Elli, additional

Published
2023
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37. Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms

Author

90839721, 10431850, Nannya, Yasuhito, Tobiasson, Magnus, Sato, Shinya, Bernard, Elsa, Ohtake, Shigeki, Takeda, June, Creignou, Maria, Zhao, Lanying, Kusakabe, Manabu, Shibata, Yuhei, Nakamura, Nobuhiko, Watanabe, Mizuki, Hiramoto, Nobuhiro, Shiozawa, Yusuke, Shiraishi, Yuichi, Tanaka, Hiroko, Yoshida, Kenichi, Kakiuchi, Nobuyuki, Makishima, Hideki, Nakagawa, Masahiro, Usuki, Kensuke, Watanabe, Mitsumasa, Imada, Kazunori, Handa, Hiroshi, Taguchi, Masataka, Kiguchi, Toru, Ohyashiki, Kazuma, Ishikawa, Takayuki, Takaori-Kondo, Akifumi, Tsurumi, Hisashi, Kasahara, Senji, Chiba, Shigeru, Naoe, Tomoki, Miyano, Satoru, Papaemanuil, Elli, Miyazaki, Yasushi, Hellström-Lindberg, Eva, Ogawa, Seishi, 90839721, 10431850, Nannya, Yasuhito, Tobiasson, Magnus, Sato, Shinya, Bernard, Elsa, Ohtake, Shigeki, Takeda, June, Creignou, Maria, Zhao, Lanying, Kusakabe, Manabu, Shibata, Yuhei, Nakamura, Nobuhiko, Watanabe, Mizuki, Hiramoto, Nobuhiro, Shiozawa, Yusuke, Shiraishi, Yuichi, Tanaka, Hiroko, Yoshida, Kenichi, Kakiuchi, Nobuyuki, Makishima, Hideki, Nakagawa, Masahiro, Usuki, Kensuke, Watanabe, Mitsumasa, Imada, Kazunori, Handa, Hiroshi, Taguchi, Masataka, Kiguchi, Toru, Ohyashiki, Kazuma, Ishikawa, Takayuki, Takaori-Kondo, Akifumi, Tsurumi, Hisashi, Kasahara, Senji, Chiba, Shigeru, Naoe, Tomoki, Miyano, Satoru, Papaemanuil, Elli, Miyazaki, Yasushi, Hellström-Lindberg, Eva, and Ogawa, Seishi

Abstract

Azacitidine is a mainstay of therapy for MDS-related diseases. The purpose of our study is to elucidate the effect of gene mutations on hematological response and overall survival (OS), particularly focusing on their post-treatment clone size. We enrolled a total of 449 patients with MDS or related myeloid neoplasms. They were analyzed for gene mutations in pre- (n=449) and post- (n=289) treatment bone marrow samples using targeted-capture sequencing to assess the impact of gene mutations and their post-treatment clone size on treatment outcomes. In Cox proportional hazard modeling, multi-hit TP53 mutation (HR, 2.03; 95% CI, 1.42-2.91; P<.001), EZH2 mutation (HR, 1.71; 95% CI, 1.14-2.54; P=.009), and DDX41 mutations (HR, 0.33; 95% CI, 0.17-0.62; P<.001), together with age, high-risk karyotypes, low platelet, and high blast counts, independently predicted OS. Post-treatment clone size accounting for all drivers significantly correlated with International Working Group (IWG)-response (P<.001, trend test), except for that of DDX41-mutated clones, which did not predict IWG-response. Combined, IWG-response and post-treatment clone size further improved the prediction of the original model and even that of a recently proposed molecular prediction model, IPSS-M (c-index, 0.653 vs 0.688; P<.001, likelihood ratio test). In conclusion, evaluation of post-treatment clone size, together with pre-treatment mutational profile as well as IWG-response have a role in better prognostication of azacitidine-treated myelodysplasia patients.

Published
2023

38. Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Author

Bernard, Elsa, Nannya, Yasuhito, Hasserjian, Robert P., Devlin, Sean M., Tuechler, Heinz, Medina-Martinez, Juan S., Yoshizato, Tetsuichi, Shiozawa, Yusuke, Saiki, Ryunosuke, Malcovati, Luca, Levine, Max F., Arango, Juan E., Zhou, Yangyu, Solé, Francesc, Cargo, Catherine A., Haase, Detlef, Creignou, Maria, Germing, Ulrich, Zhang, Yanming, Gundem, Gunes, Sarian, Araxe, van de Loosdrecht, Arjan A., Jädersten, Martin, Tobiasson, Magnus, Kosmider, Olivier, Follo, Matilde Y., Thol, Felicitas, Pinheiro, Ronald F., Santini, Valeria, Kotsianidis, Ioannis, Boultwood, Jacqueline, Santos, Fabio P. S., Schanz, Julie, Kasahara, Senji, Ishikawa, Takayuki, Tsurumi, Hisashi, Takaori-Kondo, Akifumi, Kiguchi, Toru, Polprasert, Chantana, Bennett, John M., Klimek, Virginia M., Savona, Michael R., Belickova, Monika, Ganster, Christina, Palomo, Laura, Sanz, Guillermo, Ades, Lionel, Della Porta, Matteo Giovanni, Elias, Harold K., Smith, Alexandra G., Werner, Yesenia, Patel, Minal, Viale, Agnès, Vanness, Katelynd, Neuberg, Donna S., Stevenson, Kristen E., Menghrajani, Kamal, Bolton, Kelly L., Fenaux, Pierre, Pellagatti, Andrea, Platzbecker, Uwe, Heuser, Michael, Valent, Peter, Chiba, Shigeru, Miyazaki, Yasushi, Finelli, Carlo, Voso, Maria Teresa, Shih, Lee-Yung, Fontenay, Michaela, Jansen, Joop H., Cervera, José, Atsuta, Yoshiko, Gattermann, Norbert, Ebert, Benjamin L., Bejar, Rafael, Greenberg, Peter L., Cazzola, Mario, Hellström-Lindberg, Eva, Ogawa, Seishi, and Papaemmanuil, Elli

Published
2021
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40. Transfusion Patterns during Early Follow-up Predict Overall Survival Independently of IPSS-M in Patients with Myelodysplastic Syndromes

Author

Creignou, Maria, primary, Bernard, Elsa, additional, Crowther, Michael, additional, Tranberg, Anna, additional, Ejerblad, Elisabeth, additional, Nilsson, Lars, additional, Garelius, Hege, additional, Antunovic, Petar, additional, Rasmussen, Bengt Erik Holger, additional, Lorenz, Fryderyk, additional, Todisco, Gabriele, additional, Walldin, Gunilla, additional, Mortera-Blanco, Teresa, additional, Jansson, Monika, additional, Tobiasson, Magnus, additional, Edgren, Gustaf, additional, Jadersten, Martin, additional, Papaemmanuil, Elli, additional, and Hellström-Lindberg, Eva, additional

Published
2022
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41. Incidence, Clinical Associations, and Co-Mutation Patterns of UBA1 Mutations in MDS

Author

Sirenko, Maria, primary, Bernard, Elsa, additional, Beck, David B., additional, Creignou, Maria, additional, Domenico, Dylan, additional, Farina, Andrea, additional, Arango, Juan E, additional, Kosmider, Olivier, additional, Hasserjian, Robert P., additional, Jadersten, Martin, additional, Germing, Ulrich, additional, Sanz, Guillermo, additional, van de Loosdrecht, Arjan A., additional, Follo, Matilde Y, additional, Thol, Felicitas R., additional, Zamora, Lurdes, additional, Pinheiro, Ronald Feitosa, additional, Pellagatti, Andrea, additional, Elias, Harold K., additional, Haase, Detlef, additional, Ganster, Christina, additional, Ades, Lionel, additional, Tobiasson, Magnus, additional, Palomo, Laura, additional, Della Porta, Matteo G., additional, Huberman, Kety, additional, Fenaux, Pierre, additional, Belickova, Monika, additional, Savona, Michael R., additional, Klimek, Virginia M., additional, Santos, Fabio Pires de Souza, additional, Boultwood, Jacqueline, additional, Kotsianidis, Ioannis, additional, Santini, Valeria, additional, Solé, Francesc, additional, Platzbecker, Uwe, additional, Heuser, Michael, additional, Valent, Peter, additional, Finelli, Carlo, additional, Voso, Maria Teresa, additional, Shih, Lee-Yung, additional, Ogawa, Seishi, additional, Fontenay, Michaela, additional, Jansen, Joop H., additional, Cervera, Jose, additional, Ebert, Benjamin L., additional, Bejar, Rafael, additional, Greenberg, Peter L, additional, Gattermann, Norbert, additional, Malcovati, Luca, additional, Cazzola, Mario, additional, Hellström-Lindberg, Eva, additional, and Papaemmanuil, Elli, additional

Published
2022
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44. 'Randomized phase II study of azacitidine +/- lenalidomide in higher-risk myelodysplastic syndromes and acute myeloid leukemia with a karyotype including Del(5q)'

Author

Rasmussen, Bengt, Gohring, Gudrun, Bernard, Elsa, Nilsson, Lars, Tobiasson, Magnus, Jadersten, Martin, Garelius, Hege, Dybedal, Ingunn, Gronbaek, Kirsten, Ejerblad, Elisabeth, Lorenz, Fryderyk, Flogegard, Max, Marcher, Claus Werenberg, oster Fernstrom, Annette, Cavelier, Lucia, Papaemmanuil, Elli, Ebeling, Freja, Kittang, Astrid Olsnes, Norgaard, Jan Maxwell, Saft, Leonie, Mollgard, Lars, Hellstrom-Lindberg, Eva, Clinicum, HUS Comprehensive Cancer Center, and Hematologian yksikkö

Subjects
education, 3122 Cancers
Abstract

Non

Published
2022

45. Transfusion Patterns during Early Follow-up Predict Overall Survival Independently of IPSS-M in Patients with Myelodysplastic Syndromes

Author

Creignou, Maria, Bernard, Elsa, Crowther, Michael, Tranberg, Anna, Ejerblad, Elisabeth, Nilsson, Lars, Garelius, Hege, Antunovic, Petar, Rasmussen, Bengt, Lorenz, Fryderyk, Todisco, Gabriele, Walldin, Gunilla, Mortera-Blanco, Teresa, Jansson, Monika, Tobiasson, Magnus, Edgren, Gustaf, Jadersten, Martin, Papaemmanuil, Elli, Hellström-Lindberg, Eva, Creignou, Maria, Bernard, Elsa, Crowther, Michael, Tranberg, Anna, Ejerblad, Elisabeth, Nilsson, Lars, Garelius, Hege, Antunovic, Petar, Rasmussen, Bengt, Lorenz, Fryderyk, Todisco, Gabriele, Walldin, Gunilla, Mortera-Blanco, Teresa, Jansson, Monika, Tobiasson, Magnus, Edgren, Gustaf, Jadersten, Martin, Papaemmanuil, Elli, and Hellström-Lindberg, Eva

Published
2022
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46. Molecular International Prognostic Scoring System for Myelodysplastic Syndromes

Author

Bernard, Elsa, primary, Tuechler, Heinz, additional, Greenberg, Peter L., additional, Hasserjian, Robert P., additional, Arango Ossa, Juan E., additional, Nannya, Yasuhito, additional, Devlin, Sean M., additional, Creignou, Maria, additional, Pinel, Philippe, additional, Monnier, Lily, additional, Gundem, Gunes, additional, Medina-Martinez, Juan S., additional, Domenico, Dylan, additional, Jädersten, Martin, additional, Germing, Ulrich, additional, Sanz, Guillermo, additional, van de Loosdrecht, Arjan A., additional, Kosmider, Olivier, additional, Follo, Matilde Y., additional, Thol, Felicitas, additional, Zamora, Lurdes, additional, Pinheiro, Ronald F., additional, Pellagatti, Andrea, additional, Elias, Harold K., additional, Haase, Detlef, additional, Ganster, Christina, additional, Ades, Lionel, additional, Tobiasson, Magnus, additional, Palomo, Laura, additional, Della Porta, Matteo Giovanni, additional, Takaori-Kondo, Akifumi, additional, Ishikawa, Takayuki, additional, Chiba, Shigeru, additional, Kasahara, Senji, additional, Miyazaki, Yasushi, additional, Viale, Agnes, additional, Huberman, Kety, additional, Fenaux, Pierre, additional, Belickova, Monika, additional, Savona, Michael R., additional, Klimek, Virginia M., additional, Santos, Fabio P. S., additional, Boultwood, Jacqueline, additional, Kotsianidis, Ioannis, additional, Santini, Valeria, additional, Solé, Francesc, additional, Platzbecker, Uwe, additional, Heuser, Michael, additional, Valent, Peter, additional, Ohyashiki, Kazuma, additional, Finelli, Carlo, additional, Voso, Maria Teresa, additional, Shih, Lee-Yung, additional, Fontenay, Michaela, additional, Jansen, Joop H., additional, Cervera, José, additional, Gattermann, Norbert, additional, Ebert, Benjamin L., additional, Bejar, Rafael, additional, Malcovati, Luca, additional, Cazzola, Mario, additional, Ogawa, Seishi, additional, Hellström-Lindberg, Eva, additional, and Papaemmanuil, Elli, additional

Published
2022
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48. Les récits judiciaires de l'Europe. Dynamiques et conflits

Author

Bernard, Elsa, Bailleux, Antoine, Jacquot, Sophie, Landenne, Quentin, Centre de recherche Droits et perspectives du droit - ULR 4487 (CRDP), and Université de Lille

Subjects
[SHS.DROIT]Humanities and Social Sciences/Law
Published
2021

50. Whole Transcriptome Analysis Identifies Distinct Gene Expression Profiles between SF3B1mut and SF3B1 wt Myelodysplastic Syndrome with Ring Sideroblasts

Author

Todisco, Gabriele, primary, Creignou, Maria, additional, Bernard, Elsa, additional, Björklund, Ann-Charlotte, additional, Moura, Pedro Luis, additional, Jansson, Monika, additional, Chang, David, additional, Venckute, Sigita, additional, Walldin, Gunilla, additional, Malcovati, Luca, additional, Tesi, Bianca, additional, Mortera-Blanco, Teresa, additional, Barbosa, Indira, additional, Papaemmanuil, Elli, additional, and Hellstrom Lindberg, Eva, additional

Published
2021
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