20 results on '"Berlengiero, Virginia"'
Search Results
2. Development and implementation of the AIDA International Registry for patients with Behçet’s disease
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Vitale, Antonio, Della Casa, Francesca, Ragab, Gaafar, Almaghlouth, Ibrahim A., Lopalco, Giuseppe, Pereira, Rosa Maria, Guerriero, Silvana, Govoni, Marcello, Sfikakis, Petros P., Giacomelli, Roberto, Ciccia, Francesco, Monti, Sara, Ruscitti, Piero, Piga, Matteo, Lomater, Claudia, Tufan, Abdurrahman, Opris-Belinski, Daniela, Emmi, Giacomo, Hernández-Rodríguez, José, Şahin, Ali, Sebastiani, Gian Domenico, Bartoloni, Elena, Akkoç, Nurullah, Gündüz, Özgül Soysal, Cattalini, Marco, Conti, Giovanni, Hatemi, Gulen, Maier, Armin, Parronchi, Paola, Del Giudice, Emanuela, Erten, Sukran, Insalaco, Antonella, Li Gobbi, Francesca, Maggio, Maria Cristina, Shahram, Farhad, Caggiano, Valeria, Hegazy, Mohamed Tharwat, Asfina, Kazi Nur, Morrone, Maria, Prado, Leandro L., Dammacco, Rosanna, Ruffilli, Francesca, Arida, Aikaterini, Navarini, Luca, Pantano, Ilenia, Cavagna, Lorenzo, Conforti, Alessandro, Cauli, Alberto, Marucco, Elena Maria, Kucuk, Hamit, Ionescu, Ruxandra, Mattioli, Irene, Espinosa, Gerard, Araújo, Olga, Karkaş, Burak, Canofari, Claudia, Sota, Jurgen, Laymouna, Ahmed Hatem, Bedaiwi, Asma. A., Colella, Sergio, Giardini, Henrique Ayres M., Albano, Valeria, Lo Monaco, Andrea, Fragoulis, George E., Kardas, Riza Can, Berlengiero, Virginia, Hussein, Mohamed A., Ricci, Francesca, La Torre, Francesco, Rigante, Donato, Więsik-Szewczyk, Ewa, Frassi, Micol, Gentileschi, Stefano, Tosi, Gian Marco, Dagostin, Marilia Ambiel, Mahmoud, Ayman Abdel-Monem Ahmed, Tarsia, Maria, Alessio, Giovanni, Cimaz, Rolando, Giani, Teresa, Gaggiano, Carla, Iannone, Florenzo, Cipriani, Paola, Mourabi, Mariam, Spedicato, Veronica, Barneschi, Sara, Aragona, Emma, Balistreri, Alberto, Frediani, Bruno, Fabiani, Claudia, and Cantarini, Luca
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- 2022
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3. Correction to: The diagnostic role of pathergy test in patients with Behçet’s disease from the Western Europe
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Vitale, Antonio, Berlengiero, Virginia, Caggiano, Valeria, Barneschi, Sara, Mourabi, Mariam, Sota, Jurgen, Gentileschi, Stefano, Maggio, Maria Cristina, Gaggiano, Carla, Tarsia, Maria, Tosi, Gian Marco, Lopalco, Giuseppe, Fabiani, Claudia, Frediani, Bruno, and Cantarini, Luca
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- 2023
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4. The Role of Biologic Agents in the Management of Pediatric-Onset Noninfectious Posterior Scleritis.
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Gaggiano, Carla, Berlengiero, Virginia, Vitale, Antonio, Tarsia, Maria, Grosso, Salvatore, Tosi, Gian Marco, Ricci, Francesca, Sota, Jurgen, Caggiano, Valeria, Frediani, Bruno, Cantarini, Luca, Cattalini, Marco, and Fabiani, Claudia
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BIOLOGICALS , *PEDIATRIC ophthalmology , *VISION , *SCLERITIS , *TREATMENT duration - Abstract
Registry-based observational prospective study aimed at describing the use of biologic drugs in pediatric-onset scleritis. Data were collected at baseline, at 3-, 6-, 12-month follow-up and at last assessment. Scleral inflammation was graded according to Sen classification. Five patients (9 eyes) treated with adalimumab, infliximab, abatacept and secukinumab were included. All patients were previously treated with conventional immunosuppressors and glucocorticoids. Median biologic treatment duration was 28 (IQR = 118) months. At 6-months, scleritis resolved in all eyes. At 12-months, complete disease control was observed in 7/9 eyes (77.8%). The number of relapses 12 months before and after treatment initiation was 17 and 2, respectively. Mean BCVA was 0.83 (range 0.3–1.0) at baseline and 1.0 for all eyes after 12 months. Glucocorticoids had been withdrawn in 4/5 patients. In conclusion, biological agents proved to be effective in pediatric-onset scleritis, allowing a noticeable steroid-sparing effect and preserving visual function and bulbar integrity. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Clinical profile and evolution of patients with juvenile-onset Behçet’s syndrome over a 25-year period: insights from the AIDA network
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Sota, Jurgen, Rigante, Donato, Lopalco, Giuseppe, Emmi, Giacomo, Gentileschi, Stefano, Gaggiano, Carla, Ciarcia, Luisa, Berlengiero, Virginia, Mourabi, Mariam, Ricco, Nicola, Barneschi, Sara, Mattioli, Irene, Tosi, Gian Marco, Frediani, Bruno, Tarsia, Maria, di Scala, Gerardo, Vitale, Antonio, Iannone, Florenzo, Fabiani, Claudia, and Cantarini, Luca
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- 2021
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6. Baricitinib retention rate: ‘real-life’ data from a mono-centric cohort of patients affected by rheumatoid arthritis
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Baldi, Caterina, primary, Berlengiero, Virginia, additional, Falsetti, Paolo, additional, Cartocci, Alessandra, additional, Conticini, Edoardo, additional, D’Alessandro, Roberto, additional, D’Ignazio, Emilio, additional, Bardelli, Marco, additional, Fabbroni, Marta, additional, Cantarini, Luca, additional, Frediani, Bruno, additional, and Gentileschi, Stefano, additional
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- 2023
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7. Peripheral Macrovascular Involvement in Systemic Sclerosis: A Cohort Study by Color and Spectral Doppler Ultrasonography
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D’Alessandro, Roberto, primary, Garcia Gonzalez, Estrella, additional, Falsetti, Paolo, additional, Conticini, Edoardo, additional, d’Alessandro, Miriana, additional, Selvi, Enrico, additional, Bellisai, Francesca, additional, Berlengiero, Virginia, additional, Vallifuoco, Giulia, additional, Pata, Anna Paola, additional, Bardelli, Marco, additional, Baldi, Caterina, additional, Cantarini, Luca, additional, Bargagli, Elena, additional, and Frediani, Bruno, additional
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- 2023
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8. Comparing biologic options for the management of Behcet’s disease-related uveitis
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Vitale, Antonio, primary, Caggiano, Valeria, additional, Berlengiero, Virginia, additional, Perfetti, Maria Orsetta, additional, Sota, Jurgen, additional, Tosi, Gian Marco, additional, Frediani, Bruno, additional, Cantarini, Luca, additional, and Fabiani, Claudia, additional
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- 2023
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9. Effects of antiresorptive agents on body composition: a case-control retrospective study.
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Al Khayyat, Suhel Gabriele, primary, Fogliame, Giuseppe, additional, Conticini, Edoardo, additional, Berlengiero, Virginia, additional, Falsetti, Paolo, additional, Gentileschi, Stefano, additional, Baldi, Caterina, additional, Bardelli, Marco, additional, Cantarini, Luca, additional, and Frediani, Bruno, additional
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- 2023
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10. The diagnostic role of pathergy test in patients with Behçet’s disease from the Western Europe
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Antonio, Vitale, primary, Berlengiero, Virginia, additional, Caggiano, Valeria, additional, Barneschi, Sara, additional, Mourabi, Mariam, additional, Sota, Jurgen, additional, Gentileschi, Stefano, additional, Maggio, Maria Cristina, additional, Gaggiano, Carla, additional, Tarsia, Maria, additional, Tosi, Gian Marco, additional, Lopalco, Giuseppe, additional, Fabiani, Claudia, additional, Frediani, Bruno, additional, and Cantarini, Luca, additional
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- 2022
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11. The Role of Biologic Agents in the Management of Pediatric-Onset Noninfectious Posterior Scleritis
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Gaggiano, Carla, primary, Berlengiero, Virginia, additional, Vitale, Antonio, additional, Tarsia, Maria, additional, Grosso, Salvatore, additional, Tosi, Gian Marco, additional, Ricci, Francesca, additional, Sota, Jurgen, additional, Caggiano, Valeria, additional, Frediani, Bruno, additional, Cantarini, Luca, additional, Cattalini, Marco, additional, and Fabiani, Claudia, additional
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- 2022
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12. Development and Implementation of the AIDA International Registry for Patients With Undifferentiated Systemic AutoInflammatory Diseases
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Della Casa, Francesca, primary, Vitale, Antonio, additional, Lopalco, Giuseppe, additional, Ruscitti, Piero, additional, Ciccia, Francesco, additional, Emmi, Giacomo, additional, Cattalini, Marco, additional, Wiesik-Szewczyk, Ewa, additional, Maggio, Maria Cristina, additional, Ogunjimi, Benson, additional, Sfikakis, Petros P., additional, Tufan, Abdurrahman, additional, Al-Mayouf, Sulaiman M., additional, Del Giudice, Emanuela, additional, Aragona, Emma, additional, La Torre, Francesco, additional, Sota, Jurgen, additional, Colella, Sergio, additional, Di Cola, Ilenia, additional, Iacono, Daniela, additional, Mattioli, Irene, additional, Jahnz-Rózyk, Karina, additional, Joos, Rik, additional, Laskari, Katerina, additional, Gaggiano, Carla, additional, Abbruzzese, Anna, additional, Cipriani, Paola, additional, Rozza, Gelsomina, additional, AlSaleem, Alhanouf, additional, Yildirim, Derya, additional, Tarsia, Maria, additional, Ragab, Gaafar, additional, Ricci, Francesca, additional, Cardinale, Fabio, additional, Korzeniowska, Marcelina, additional, Frassi, Micol, additional, Caggiano, Valeria, additional, Saad, Moustafa Ali, additional, Pereira, Rosa Maria, additional, Berlengiero, Virginia, additional, Gentileschi, Stefano, additional, Guerriero, Silvana, additional, Giani, Teresa, additional, Gelardi, Viviana, additional, Iannone, Florenzo, additional, Giardini, Henrique Ayres Mayrink, additional, Almaghlouth, Ibrahim A., additional, Kardas, Riza Can, additional, Ait-Idir, Djouher, additional, Frediani, Bruno, additional, Balistreri, Alberto, additional, Fabiani, Claudia, additional, Rigante, Donato, additional, and Cantarini, Luca, additional
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- 2022
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13. Peripheral Macrovascular Involvement in Systemic Sclerosis: A Cohort Study by Color and Spectral Doppler Ultrasonography.
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D'Alessandro, Roberto, Garcia Gonzalez, Estrella, Falsetti, Paolo, Conticini, Edoardo, d'Alessandro, Miriana, Selvi, Enrico, Bellisai, Francesca, Berlengiero, Virginia, Vallifuoco, Giulia, Pata, Anna Paola, Bardelli, Marco, Baldi, Caterina, Cantarini, Luca, Bargagli, Elena, and Frediani, Bruno
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SYSTEMIC scleroderma ,COLOR Doppler ultrasonography ,RADIAL artery ,INTERSTITIAL lung diseases ,COHORT analysis ,ARTERIAL occlusions - Abstract
Objectives: Systemic sclerosis (SSc) is a disease characterized by diffuse sclerosis of skin and organs and small vessel vasculopathy. Despite it, large vessels can also be involved with ulnar artery vasculopathy, revealing as a more frequent feature of SSc. The aim of this paper is to assess the macrovascular involvement of SSc patients through an ultrasound (US) evaluation of radial and ulnar arteries. Methods: Radial and ulnar resistance indices (RIs) and peak systolic velocity (PV) (cm/s) together with clinical features of SSc patients were evaluated. Raynaud phenomenon (RP) and healthy control (HC) groups were used for comparison. Results: Forty-three SSc patients were evaluated. Twelve patients (28%) had ulnar artery occlusions (UAOs). In nine cases (75%), UAOs were bilateral. A high UAO prevalence (42%) was found in SSc patients with late nailfold-video-capillaroscopy (NVC) pattern (p = 0.0264). Patients with UAOs had digital ulcers (DUs) in 10 cases (83.3%). Radial and ulnar PVs were lower in SSc and RP patients than the HC group. Radial and ulnar RIs were higher in SSc and RP patients than the HC group. A decision tree analysis led to the classification of 70% of SSc patients with an ulnar RI > 0.82 and ulnar PV > 2.8 cm/s. The most influential variables on UAO development were interstitial lung disease (ILD) (p = 0.002) and NVC pattern (p = 0.002). A positive correlation was shown between modified Rodnan skin score (mRSS) and ILD (p = 0.283; r = 0.033), mRSS and DU (r = 0.344; p = 0.012) and DU and ILD (r = 0.303; p = 0.024). Male sex was associated with increased UAO frequency (p = 0.042). Conclusions: UAO is a peculiar feature of severe SSc present in 28% of the cases, particularly associated with the presence of ILD and late NVC pattern. In 75% of the cases, UAOs are bilateral. DUs are very frequent in patients with UAOs (83%). The RI evaluated by US could be useful to distinguish SSc from HC patients. US could be a useful tool for assessing high-risk DU development in patients. [ABSTRACT FROM AUTHOR]
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- 2023
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14. The diagnostic role of pathergy test in patients with Behçet's disease from the Western Europe.
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Antonio, Vitale, Berlengiero, Virginia, Caggiano, Valeria, Barneschi, Sara, Mourabi, Mariam, Sota, Jurgen, Gentileschi, Stefano, Maggio, Maria Cristina, Gaggiano, Carla, Tarsia, Maria, Tosi, Gian Marco, Lopalco, Giuseppe, Fabiani, Claudia, Frediani, Bruno, and Cantarini, Luca
- Abstract
The aim of the study is to evaluate the frequency and features of positive pathergy test (PPT) in Italy, its role in the diagnosis of Behçet's disease (BD), and any association with other BD-related manifestations. 52 BD patients, 52 patients with axial spondyloarthritis (ax-SpA), and 26 healthy controls (HCs) underwent intradermal injection of normal saline and intradermal needle soaked with fresh self-saliva. The results of pathergy tests were statistically analysed in the light of demographic, clinical, and therapeutic features of subjects enrolled. Pathergy test performed with saline resulted always negative in all groups. Skin prick test using self-saliva resulted in the occurrence of a papule in 3 (5.8%) BD patients and in 1 (1.9%) patient with ax-SpA. A ≥ 15 mm erythematous area surrounding the needle prick site was observed in 22 (42.3%) BD patients, 5 (9.6%) patients with ax-SpA, and 2 (7.7%) HCs (p = 0.00002). The frequency of skin erythema was significantly more frequent in patients with BD than those with ax-SpA (p < 0.0001) and HCs (p = 0.003). No statistically significant differences were observed between ax-SpA patients and HCs (p = 1.000). The occurrence of skin erythema at pathergy test was not associated with any BD-related clinical manifestation. Erythema at self-saliva prick test presented a sensitivity of 42.31% (CI 28.73–56.80%) and a specificity of 91.03% (CI 82.38–96.32%). The development of a ≥ 15 mm erythematous area at self-saliva prick test could be sufficient to unveil the hyper-reactivity of the innate immune system in BD patients from Western Europe, where the development of skin erythema shows good sensitivity and specificity toward the diagnosis of BD. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Real-Life Data on the Efficacy of Canakinumab in Patients with Adult-Onset Still’s Disease
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Vitale, Antonio, primary, Berlengiero, Virginia, additional, Sota, Jurgen, additional, Ciarcia, Luisa, additional, Ricco, Nicola, additional, Barneschi, Sara, additional, Mourabi, Mariam, additional, Lopalco, Giuseppe, additional, Marzo, Chiara, additional, Bellisai, Francesca, additional, Iannone, Florenzo, additional, Frediani, Bruno, additional, and Cantarini, Luca, additional
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- 2020
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16. Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor—Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA Network
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Gaggiano, Carla, primary, Vitale, Antonio, additional, Obici, Laura, additional, Merlini, Giampaolo, additional, Soriano, Alessandra, additional, Viapiana, Ombretta, additional, Cattalini, Marco, additional, Maggio, Maria Cristina, additional, Lopalco, Giuseppe, additional, Montin, Davide, additional, Jaber, Masen Abdel, additional, Dagna, Lorenzo, additional, Manna, Raffaele, additional, Insalaco, Antonella, additional, Piga, Matteo, additional, La Torre, Francesco, additional, Berlengiero, Virginia, additional, Gelardi, Viviana, additional, Ciarcia, Luisa, additional, Emmi, Giacomo, additional, Ruscitti, Piero, additional, Caso, Francesco, additional, Cimaz, Rolando, additional, Hernández-Rodríguez, José, additional, Parronchi, Paola, additional, Sicignano, Ludovico Luca, additional, Verrecchia, Elena, additional, Iannone, Florenzo, additional, Sota, Jurgen, additional, Grosso, Salvatore, additional, Salvarani, Carlo, additional, Frediani, Bruno, additional, Giacomelli, Roberto, additional, Mencarelli, Maria Antonietta, additional, Renieri, Alessandra, additional, Rigante, Donato, additional, and Cantarini, Luca, additional
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- 2020
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17. The diagnostic role of pathergy test in patients with Behçet's disease from the Western Europe
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Vitale Antonio, Virginia Berlengiero, Valeria Caggiano, Sara Barneschi, Mariam Mourabi, Jurgen Sota, Stefano Gentileschi, Maria Cristina Maggio, Carla Gaggiano, Maria Tarsia, Gian Marco Tosi, Giuseppe Lopalco, Claudia Fabiani, Bruno Frediani, Luca Cantarini, Antonio, Vitale, Berlengiero, Virginia, Caggiano, Valeria, Barneschi, Sara, Mourabi, Mariam, Sota, Jurgen, Gentileschi, Stefano, Maggio, Maria Cristina, Gaggiano, Carla, Tarsia, Maria, Tosi, Gian Marco, Lopalco, Giuseppe, Fabiani, Claudia, Frediani, Bruno, and Cantarini, Luca
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Autoinflammatory diseases, Diagnosis, Diagnostic accuracy, Diagnostic test, Geographical differences, Management ,Settore MED/38 - Pediatria Generale E Specialistica ,Emergency Medicine ,Internal Medicine - Abstract
The aim of the study is to evaluate the frequency and features of positive pathergy test (PPT) in Italy, its role in the diagnosis of Behçet's disease (BD), and any association with other BD-related manifestations. 52 BD patients, 52 patients with axial spondyloarthritis (ax-SpA), and 26 healthy controls (HCs) underwent intradermal injection of normal saline and intradermal needle soaked with fresh self-saliva. The results of pathergy tests were statistically analysed in the light of demographic, clinical, and therapeutic features of subjects enrolled. Pathergy test performed with saline resulted always negative in all groups. Skin prick test using self-saliva resulted in the occurrence of a papule in 3 (5.8%) BD patients and in 1 (1.9%) patient with ax-SpA. A ≥ 15mm erythematous area surrounding the needle prick site was observed in 22 (42.3%) BD patients, 5 (9.6%) patients with ax-SpA, and 2 (7.7%) HCs (p = 0.00002). The frequency of skin erythema was significantly more frequent in patients with BD than those with ax-SpA (p
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- 2022
18. Development and implementation of the AIDA International Registry for patients with Behçet's disease
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Vitale, A, Della Casa, F, Ragab, G, Almaghlouth, Ia, Lopalco, G, Pereira, Rm, Guerriero, S, Govoni, M, Sfikakis, Pp, Giacomelli, R, Ciccia, F, Monti, S, Ruscitti, P, Piga, M, Lomater, C, Tufan, A, Opris-Belinski, D, Emmi, G, Hernández-Rodríguez, J, Şahin, A, Sebastiani, Gd, Bartoloni, E, Akkoç, N, Gündüz, Ös, Cattalini, M, Conti, Giorgio, Hatemi, G, Maier, A, Parronchi, P, Del Giudice, E, Erten, S, Insalaco, A, Li Gobbi, F, Maggio, Mc, Shahram, F, Caggiano, V, Hegazy, Mt, Asfina, Kn, Morrone, M, Prado, Ll, Dammacco, R, Ruffilli, F, Arida, A, Navarini, L, Pantano, I, Cavagna, L, Conforti, A, Cauli, A, Marucco, Em, Kucuk, H, Ionescu, R, Mattioli, I, Espinosa, G, Araújo, O, Karkaş, B, Canofari, C, Sota, J, Laymouna, Ah, Bedaiwi, Aa, Colella, S, Giardini, Ham, Albano, V, Lo Monaco, A, Fragoulis, Ge, Kardas, Rc, Berlengiero, V, Hussein, Ma, Ricci, F, La Torre, F, Rigante, Donato, Więsik-Szewczyk, E, Frassi, M, Gentileschi, S, Tosi, Gm, Dagostin, Ma, Mahmoud, Aaa, Tarsia, M, Alessio, G, Cimaz, R, Giani, T, Gaggiano, C, Iannone, F, Cipriani, P, Mourabi, M, Spedicato, V, Barneschi, S, Aragona, E, Balistreri, A, Frediani, B, Fabiani, C, Cantarini, L, Autoinflammatory Diseases Alliance (AIDA) Network, Vitale, Antonio, Della Casa, Francesca, Ragab, Gaafar, Almaghlouth, Ibrahim A, Lopalco, Giuseppe, Pereira, Rosa Maria, Guerriero, Silvana, Govoni, Marcello, Sfikakis, Petros P, Giacomelli, Roberto, Ciccia, Francesco, Monti, Sara, Ruscitti, Piero, Piga, Matteo, Lomater, Claudia, Tufan, Abdurrahman, Opris-Belinski, Daniela, Emmi, Giacomo, Hernández-Rodríguez, José, Şahin, Ali, Sebastiani, Gian Domenico, Bartoloni, Elena, Akkoç, Nurullah, Gündüz, Özgül Soysal, Cattalini, Marco, Conti, Giovanni, Hatemi, Gulen, Maier, Armin, Parronchi, Paola, Del Giudice, Emanuela, Erten, Sukran, Insalaco, Antonella, Li Gobbi, Francesca, Maggio, Maria Cristina, Shahram, Farhad, Caggiano, Valeria, Hegazy, Mohamed Tharwat, Asfina, Kazi Nur, Morrone, Maria, Prado, Leandro L, Dammacco, Rosanna, Ruffilli, Francesca, Arida, Aikaterini, Navarini, Luca, Pantano, Ilenia, Cavagna, Lorenzo, Conforti, Alessandro, Cauli, Alberto, Marucco, Elena Maria, Kucuk, Hamit, Ionescu, Ruxandra, Mattioli, Irene, Espinosa, Gerard, Araújo, Olga, Karkaş, Burak, Canofari, Claudia, Sota, Jurgen, Laymouna, Ahmed Hatem, Bedaiwi, Asma A, Colella, Sergio, Giardini, Henrique Ayres M, Albano, Valeria, Lo Monaco, Andrea, Fragoulis, George E, Kardas, Riza Can, Berlengiero, Virginia, Hussein, Mohamed A, Ricci, Francesca, La Torre, Francesco, Rigante, Donato, Więsik-Szewczyk, Ewa, Frassi, Micol, Gentileschi, Stefano, Tosi, Gian Marco, Dagostin, Marilia Ambiel, Mahmoud, Ayman Abdel-Monem Ahmed, Tarsia, Maria, Alessio, Giovanni, Cimaz, Rolando, Giani, Teresa, Gaggiano, Carla, Iannone, Florenzo, Cipriani, Paola, Mourabi, Mariam, Spedicato, Veronica, Barneschi, Sara, Aragona, Emma, Balistreri, Alberto, Frediani, Bruno, Fabiani, Claudia, and Cantarini, Luca
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Adult ,Registrie ,Autoinflammatory disease ,Registry ,Settore MED/16 - REUMATOLOGIA ,precision medicine ,behçet’s disease ,Settore MED/38 - Pediatria Generale E Specialistica ,Retrospective Studie ,Internal Medicine ,Humans ,Prospective Studies ,Registries ,Child ,international registry ,Retrospective Studies ,Behçet's disease ,autoinflammatory diseases ,rare diseases ,uveitis ,Behcet Syndrome ,Prospective Studie ,Uveiti ,Emergency Medicine ,Rare disease ,Human - Abstract
Purpose of the present paper is to point out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients with Behçet’s disease (BD). The Registry is a clinical physician-driven non-population- and electronic-based instrument implemented for the retrospective and prospective collection of real-life data about demographics, clinical, therapeutic, laboratory, instrumental and socioeconomic information from BD patients; the Registry is based on the Research Electronic Data Capture (REDCap) tool, which is thought to collect standardised information for clinical real-life research, and has been realised to change over time according to future scientific acquisitions and potentially communicate with other existing and future Registries dedicated to BD. Starting from January 31st, 2021, to February 7th, 2022, 110 centres from 23 countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 5993 fields organised into 16 instruments, including patient’s demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. The development of the AIDA International Registry for BD patients will facilitate the collection of standardised data leading to real-world evidence, enabling international multicentre collaborative research through data sharing, international consultation, dissemination of knowledge, inclusion of patients and families, and ultimately optimisation of scientific efforts and implementation of standardised care.Trial registration NCT05200715 in 21/01/2022.
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- 2022
19. Development and Implementation of the AIDA International Registry for Patients With Undifferentiated Systemic AutoInflammatory Diseases
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Francesca Della Casa, Antonio Vitale, Giuseppe Lopalco, Piero Ruscitti, Francesco Ciccia, Giacomo Emmi, Marco Cattalini, Ewa Wiesik-Szewczyk, Maria Cristina Maggio, Benson Ogunjimi, Petros P. Sfikakis, Abdurrahman Tufan, Sulaiman M. Al-Mayouf, Emanuela Del Giudice, Emma Aragona, Francesco La Torre, Jurgen Sota, Sergio Colella, Ilenia Di Cola, Daniela Iacono, Irene Mattioli, Karina Jahnz-Rózyk, Rik Joos, Katerina Laskari, Carla Gaggiano, Anna Abbruzzese, Paola Cipriani, Gelsomina Rozza, Alhanouf AlSaleem, Derya Yildirim, Maria Tarsia, Gaafar Ragab, Francesca Ricci, Fabio Cardinale, Marcelina Korzeniowska, Micol Frassi, Valeria Caggiano, Moustafa Ali Saad, Rosa Maria Pereira, Virginia Berlengiero, Stefano Gentileschi, Silvana Guerriero, Teresa Giani, Viviana Gelardi, Florenzo Iannone, Henrique Ayres Mayrink Giardini, Ibrahim A. Almaghlouth, Riza Can Kardas, Djouher Ait-Idir, Bruno Frediani, Alberto Balistreri, Claudia Fabiani, Donato Rigante, Luca Cantarini, Della Casa, Francesca, Vitale, Antonio, Lopalco, Giuseppe, Ruscitti, Piero, Ciccia, Francesco, Emmi, Giacomo, Cattalini, Marco, Wiesik-Szewczyk, Ewa, Maggio, Maria Cristina, Ogunjimi, Benson, Sfikakis, Petros P, Tufan, Abdurrahman, Al-Mayouf, Sulaiman M, Del Giudice, Emanuela, Aragona, Emma, La Torre, Francesco, Sota, Jurgen, Colella, Sergio, Di Cola, Ilenia, Iacono, Daniela, Mattioli, Irene, Jahnz-Rózyk, Karina, Joos, Rik, Laskari, Katerina, Gaggiano, Carla, Abbruzzese, Anna, Cipriani, Paola, Rozza, Gelsomina, Alsaleem, Alhanouf, Yildirim, Derya, Tarsia, Maria, Ragab, Gaafar, Ricci, Francesca, Cardinale, Fabio, Korzeniowska, Marcelina, Frassi, Micol, Caggiano, Valeria, Saad, Moustafa Ali, Pereira, Rosa Maria, Berlengiero, Virginia, Gentileschi, Stefano, Guerriero, Silvana, Giani, Teresa, Gelardi, Viviana, Iannone, Florenzo, Giardini, Henrique Ayres Mayrink, Almaghlouth, Ibrahim A, Kardas, Riza Can, Ait-Idir, Djouher, Frediani, Bruno, Balistreri, Alberto, Fabiani, Claudia, Rigante, Donato, Cantarini, Luca, and AlSaleem, Alhanouf
- Subjects
Registry ,Settore MED/16 - REUMATOLOGIA ,precision medicine ,rare diseases ,General Medicine ,personalized medicine ,autoinflammatory diseases ,International Registry ,Settore MED/38 - Pediatria Generale E Specialistica ,autoinflammatory disease ,Autoinflammation ,Human medicine - Abstract
ObjectiveThis paper points out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients affected by Undifferentiated Systemic AutoInflammatory Diseases (USAIDs).MethodsThis is an electronic registry employed for real-world data collection about demographics, clinical, laboratory, instrumental and socioeconomic data of USAIDs patients. Data recruitment, based on the Research Electronic Data Capture (REDCap) tool, is designed to obtain standardized information for real-life research. The instrument is endowed with flexibility, and it could change over time according to the scientific acquisitions and potentially communicate with other similar tools; this platform ensures security, data quality and data governance.ResultsThe focus of the AIDA project is connecting physicians and researchers from all over the world to shed a new light on heterogeneous rare diseases. Since its birth, 110 centers from 23 countries and 4 continents have joined the AIDA project. Fifty-four centers have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 179 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry is collecting baseline and follow-up data using 3,769 fields organized into 23 instruments, which include demographics, history, symptoms, trigger/risk factors, therapies, and healthcare information access for USAIDs patients.ConclusionsThe development of the AIDA International Registry for USAIDs patients will facilitate the online collection of real standardized data, connecting a worldwide group of researchers: the Registry constitutes an international multicentre observational groundwork aimed at increasing the patient cohort of USAIDs in order to improve our knowledge of this peculiar cluster of autoinflammatory diseases. NCT 05200715 available at https://clinicaltrials.gov/.
- Published
- 2022
20. Clinical and subclinical atherosclerosis in patients with systemic sclerosis: an observational, multicentre study of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale).
- Author
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Liakouli V, Verde I, Ruscitti P, Di Vico C, Ruggiero A, Mauro D, Forte G, Navarini L, Di Donato S, Bearzi P, Minerba M, Bertolini N, Favoino E, Destro Castaniti GM, D'Alessandro R, Berlengiero V, Italiano N, Bellisai F, Caso F, Guggino G, Corrado A, Triggianese P, Lo Gullo A, Mandraffino G, Cantarini L, Cipriani P, Cantatore FP, Chimenti MS, Perosa F, Iagnocco A, Docimo L, Giacomelli R, and Ciccia F
- Subjects
- Humans, Female, Male, Middle Aged, Italy epidemiology, Aged, Adult, Prevalence, Risk Factors, Aged, 80 and over, Young Adult, Ultrasonography, Doppler, Asymptomatic Diseases, Carotid Artery Diseases epidemiology, Carotid Artery Diseases diagnostic imaging, Plaque, Atherosclerotic diagnostic imaging, Plaque, Atherosclerotic epidemiology, Scleroderma, Systemic epidemiology, Scleroderma, Systemic complications, Atherosclerosis epidemiology, Atherosclerosis diagnostic imaging, Atherosclerosis etiology, Carotid Intima-Media Thickness
- Abstract
Objectives: Conflicting results about clinical and subclinical atherosclerosis in systemic sclerosis (SSc) and the associated risk factors have been reported. Hence, we aimed to determine the prevalence of clinical and subclinical atherosclerosis in a large number of Italian SSc patients and the associated risk factors., Methods: This study included 613 SSc patients from 11 Italian tertiary Rheumatologic Units. All patients underwent full history taking, clinical examination, and relevant laboratory and radiological investigations. Doppler ultrasonography (US) of the common carotid and upper and lower limbs was performed to measure carotid and femoral intima-media thickness (cIMT and fIMT), and carotid and peripheral atheroma plaques. Doppler US of the brachial artery was performed to measure flow-mediated dilatation (FMD)., Results: Patients were mostly women (91.4%) with a median age of 61 years (range, 20-100); a median disease duration of 14 years (range, 0-77) from the onset of the first non-Raynaud's phenomenon (RP); 9.3% had a history of clinical atherosclerosis (9 stable/unstable angina, 21 myocardial infarctions, 24 heart failure, 3 strokes, 8 transient ischaemic attack, 6 intermittent claudication, 10 atrial thrombo-embolism). In 37.1% of patients, subclinical atherosclerosis was detected, after excluding those with a history of clinical atherosclerosis. The prevalence of clinical and subclinical atherosclerosis was higher than that reported by the European Society of Cardiology and observational studies that enrolled Italian healthy individuals as a control group, respectively., Conclusions: A higher prevalence of clinical and subclinical atherosclerosis was detected in SSc Italian patients and correlated with traditional and SSc-related risk factors.
- Published
- 2024
- Full Text
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