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Source at https://vkm.no/ At request from the Norwegian Food Safety Authority (NFSA), VKM has identified food groups and food items consumed by the Norwegian population that are relevant for monitoring regarding content of one or more undesirable chemical substances (Figure 1). Undesirable chemical substances were defined as chemical substances in food that may constitute a potential health risk. VKM has created a knowledge base (an Excel file) as a tool for planning and prioritising monitoring of foods and undesirable chemical substances. The substance groups included in the knowledge base are flavourings, food additives, metals and metalloids, natural toxins, persistent organic pollutants, process-induced contaminants, substances in food contact materials, substances in food supplements, and trace elements. More than 40 different substances were included.

Source at https://vkm.no/

At request from the Norwegian Food Safety Authority (NFSA), VKM has identified food groups and food items consumed by the Norwegian population that are relevant for monitoring regarding content of one or more undesirable chemical substances (Figure 1). Undesirable chemical substances were defined as chemical substances in food that may constitute a potential health risk. Paid open access

Havforskningsinstituttet (HI) og Veterinærinstituttet (VI) fikk en felles bestilling av Nærings- og fiskeridepartementet om å analysere effektene av ulike scenarioer for en ny lokalitetsstruktur i produksjonsområde 3 som kan gi mindre spredning av lakselus, ILA og PD mellom lokalitetene. Det er antatt at mindre smitte mellom lokalitetene vil gjøre det lettere å drive oppdrett av laks, med lave luseverdier, bedre fiskehelse og fiskevelferd, og dermed øke bærekraften. Ved hjelp av biofysisk modellering og nettverksanalyse av spredning av lakselus, PD og ILA mellom lokaliteter er det anslått at flytting av produksjon fra særlig smittespredende lokaliteter til mindre smittespredende lokaliteter, kan redusere den totale smitten mellom lokalitetene. Analysene viser at ved å fjerne tilfeldige lokaliteter hvor man flytter biomassen til de resterende lokalitetene vil redusere smittepresset, men ikke like effektivt som ved en strategisk flytting av biomasse fra de “verste” til de beste lokalitetene med tanke på smittespredning. I et av scenariene som er testet med Havforskningsinstituttet sine modeller er det indikert at smitten mellom lokalitetene kan reduseres med 46% for lakselus og 30% for virus, ved å redusere fra dagens 135 lokaliteter ned til 100 matfisklokaliteter – dette uten å redusere den totale produksjonen i produksjonsområdet. På tilsvarende måte indikerer Veterinærinstituttet sin lusemodell at en ved tilfeldig fjerning av halvparten av alle lokaliteter og refordeling av biomassen til andre lokaliteter i PO3 vil få rundt regnet ca. 20% færre voksne hunnlus, 20% færre andre mobile lus, og 20% færre behandlinger i hele området. Denne effekten blir større, dersom de lokalitetene som lukkes er strategisk valgt, dvs. at de er valgt på bakgrunn av hvor mye de bidrar til spredning av lus basert på HI sin nettverksmodell. Det synes dermed å være et stort potensial for å redusere smitten mellom lokaliteter ved å redusere antall lokaliteter i PO3 og samtidig opprettholde produksjonen. Imidlertid er det behov for mer omfattende analyser og utredning av ny lokalitetsstruktur, der en tar hensyn til en rekke andre faktorer som bl.a. om lokalitetene tåler økt biomasse med tanke på organisk belastning, selskapsstruktur, muligheter for sonevise utsett, samt påvirkning på vill laksefisk før en kan anbefale konkret ny lokalitetsstruktur i PO3.

The request from NFSA and NEA: Antimicrobial agents and microorganisms are introduced to sewage systems by different human activities, from private homes, institutions such as schools and hospitals, office buildings, industrial and commercial activities, i.e., from everywhere where people work and live. The Norwegian Food Safety Authority (NFSA) and Norwegian Environment Agency (NEA) asked the Norwegian Scientific Committee for Food and Environment (Vitenskapskomiteen for mat og miljø, VKM) for an extension of the 2009 VKM report “Risk assessment of contaminants in sewage sludge applied on Norwegian soils” regarding the impact of wastewater (WW)- and sewage sludge treatment methods used in Norway, on the fate and survival of antimicrobial resistant bacteria, fate of antimicrobial resistance genes, and main drivers for resistance (e.g. antibiotics, antifungal agents, heavy metals, disinfectants). The request addressed by VKM: VKM appointed a working group, consisting of three members of the Panel on Microbial Ecology, four external members and VKM staff to prepare a draft Opinion document. The Panel on Microbial Ecology has reviewed and revised the draft prepared by the working group and approved the Opinion document “Assessment of the impact of wastewater and sewage sludge treatment methods on antimicrobial resistance”. The antimicrobial resistance cycle: Exposure to antimicrobial agents is regarded as the most important driver for development and dissemination of AMR in microorganisms. Consequently, an important location for the development of AMR is the gut of humans or animals receiving antimicrobial drug therapy. As ARB, ARG, resistance genes and antimicrobial agents will end up in the WW system, this system could be regarded as a potential hot spot for interactions between different microorganisms, between different antimicrobial agents, and between microorganisms and antimicrobial agents. Hospitals and pharmaceutical companies are regarded as being an important source for antimicrobial drug residues released in WW. At the wastewater treatment plant (WWTP), bacteria and genes end up either in the effluent wastewater fraction or in the sludge fraction. When ARB and ARG are distributed with the WW sludge, they may reach arable land when the sludge is used as soil improver and fertilising product, and thus be recycled into the food-production chain. When following the effluent WW fraction, ARB and ARB will be released into WW recipients, such as lakes, rivers or fjords, and may, from these environments, also be recycled into food production. In each step of these cycles, ARB and ARG will be introduced into new environmental compartments to which they must adapt, and to microbial communities with which they must compete for survival and growth. Depending on the bacterial species, these new environmental compartments will be more or less hostile, but they will also provide opportunities for microbial interactions, like dissemination of ARG due to horizontal gene transfer (HGT) within and between bacterial species. Findings: It is challenging to deliver a general assessment of the nature of as well as the probability for direct discharge of ARB and ARG into effluent WW and applied sludge. This is due to the combined complexity of resistance carriers, traits, various sources of variation, and the WW systems. Moreover, there is currently a lack of harmonized methods and protocols to compare studies from different systems. However, there are no strong indications that there is a significant enrichment of ARB in WWTP operated under European conditions, which, on a general level, also applies to the Norwegian situation. Although some studies indicate a slight increase in the fraction of ARB, the absolute reduction in bacterial load during WW treatment (WWT) is significant; removal of between 99 % to 99.9 % of faecal indicator bacteria is generally achieved by secondary treatment, including biological and physico chemical treatment steps. Effluent WW is often released into water recipients, and there are many mechanisms (physical, mechanical, and chemical) that will limit the extent that ARB of faecal origin are transferred to the food-production chain. However, there are different views on the significance of this release for the development of AMR. Results from single studies indicate that WWTP effluents contribute little to the total AMR exposure of micro – and macro organisms in aquatic and marine environments. On the other hand, freshwater environments in general are regarded as an important reservoir of novel antibiotic resistance determinants, and in some areas, relative abundance of resistance determinants in effluents has been observed to be considerably higher than in pristine natural water sources. Some imprint of AMR in recipient waters, compared to pristine waters, is unavoidable. During WWT, bacteria largely adhere to particles that are aggregated and precipitated to form a solid sludge. The mandatory hygienisation of sludge kills a large proportion of these bacteria, notably all thermosensitive faecal bacteria. However, the resulting hygienised sludge is still rich in bacteria, some of which are carriers of ARGs. The current Norwegian regulations on use of sludge on soil contribute to prevent contamination of food with antimicrobial resistant bacteria and antimicrobial resistance genes from sludge. Yet, soils do contain a pool of both natural and sludge-derived antimicrobial resistance. The contribution of sludge to this antimicrobial resistance pool is probably temporally limited to a period after soil amendment with sludge. A recent, comprehensive study from Sweden showed that long-term application of sewage sludge on farmland only resulted in minor changes of soil bacterial community composition. No evidence could be found for enrichment of antimicrobial resistant bacteria or antimicrobial resistance genes in soil amended with digested and stored sewage. Hospital WW contains more ARB, ARG, and antibiotic residues than municipal sewage, but the difference is not large for ARB and the impact may be minimal in large WW systems. In smaller WW infrastructures, a hospital or similar institution may have a higher impact on the effluent water from the WWTP, and this might suggest that local treatment of the WW at the hospital could be advantageous. A recent Norwegian study monitored bacterial diversity in different WW in the Oslo area, and found the highest concentration of AMR (ARB and/or ARG) in hospital WW. But surprisingly, high concentrations were also found in the studied community wastewater. The relative contribution of hospital effluents seemed low in terms of dissemination of antimicrobial resistant bacteria to the wastewater treatment plant. All measures that can be taken at source to avoid dissemination of antimicrobial agents, ARB, and ARG should be evaluated for their contribution towards combatting AMR emergence. Concentrations of antimicrobial agents, ARB, and ARG are highest in the sewage system and at the inlet to WWTPs. Separation of the different fractions of antimicrobials, ARB, and ARG for individual treatment may therefore reduce the total load reaching the WWTPs. Due to the high concentrations of ARB and ARG in the sewage system, risks from sewage pipe leakages are of concern. Intrusion of contaminated water into the drinking water distribution system should also raise concern. Rehabilitation of the sewage and drinking water networks will considerably mitigate risks. The level of sewage treatment in Norway is rather low, and upgrading will decrease the concentration of bacteria discharged. However, WWTPs are generally not designed for removal of AMR. Membrane processes seem to be the most promising option for increasing such removal rates. Future perspectives: The opinion discusses how the “concept of sensitive recipients” for requirements of the level of WWT could be revisited. This concept is currently based on controlling nutrient loads to the environment, rather than on trace contaminants or contaminants such as ARB and ARG that develop in the stressed environment. In the future, it might be of value to define requirements for WWT based on the relative increase caused by the discharge to the pollution level. Using such a paradigm, a small load with contaminants to a rather unpolluted environment would be rated as being highly critical and the discharge would require further treatment. In addition to the amount of ARB, the type of resistance and their level of horizontal mobility are also important in this aspect. This opinion also proposes the establishment of a new monitoring programme, parallel to the existing NORM and NORM-VET monitoring programmes; “NORM-ECO”. There is relatively little knowledge on AMR in non-clinical compartments, compared with hospital and other clinical settings, and parameters that would trigger immediate responses from NFAS or NEA are not yet identified. However, establishment of a “NORM-ECO”-system requires clarification of that needs further definition.

I en bestilling fra Fiskeridirektoratet (Fdir) bes Havforskningsinstituttet (HI) å opparbeide et kunnskapsgrunnlag for en vurdering av lokalitetsstrukturen i Nordfjord. I et påfølgende møte mellom Fdir og HI den 16/11-20 ble det avtalt at HI skulle utføre en konnektivitetsanalyse mellom lokaliteter i produksjonsområde 4 (PO4) ut i fra dagens lokalitetsstruktur og lusenivåer–et såkalt «null-scenario». Havforskningsinstituttet sine modeller indikerer moderate eller høye konsentrasjoner av infektive lakselus i stort sett hele PO4, unntatt indre deler av de store fjordene. Vi rapporterer høye konsentrasjoner av infektive lakselus i områdene Sognesjøen, ytre deler av Sognefjorden, Austefjord, Masfjorden, og Frøysjøen samt i flere viker og trange sund langs kystlandskapet i PO4. Smittenettverket for lakselus i PO4 ser ut til å være delt opp i 10 klynger av tett sammenkoblede lokaliteter, med generelt lignende fordeling av klynger innad i fjorder for lus og virus. Nåværende utsett-strategi fordelt på sesong og partall/oddetalls-år ser ikke ut til å påvirke klyngestrukturen til smittenettverket i PO4 i nevneverdig grad. Rangeringen av smittefaktorer i PO4 viser stor geografisk variasjon, med generelt høy eksport av smitte fra flere lokaliteter i områdene Sognesjøen, Austefjord, Masfjorden og Osterfjorden/Sørfjorden. Spesifikt for klyngen Nordfjord-Frøysjøen observerte vi lav konnektivitet med lokaliteter i andre klynger, med unntak noen få lokaliteter i Frøysjøen. Koblingene innad i Nordfjord-Frøysjøen-klyngen var dominert av selv-smitte, og da særlig på virus-siden. Ethvert koordinert tiltak innad i Nordfjord vil derfor mest sannsynlig gi god effekt grunnet lav påvirkning utenfra.

The ABC model - A Paradigm shift in Integrated Carrying Capacity Modelling.

Source at https://vkm.no/english/riskassessments/allpublications/assessmentofriskstoanimalhealthandbiodiversityfromimportandfarmingofaustralianredclawcrayfish.4.2375207615dac0245aee2789.html. Main message: It seems unlikely that the Australian red claw clayfish will establish reproductive populations under Norwegian climate conditions, but hitchhiker organisms and infectious agents could potentially follow the import, and unless managed, may pose risks to biodiversity and aquatic animal health. This is the conclusion in a risk assessment from the Norwegian Scientific Committee for Food Safety (VKM).