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1. The Five Periampullary Cancers, not Just Different Siblings but Different Families: An International Multicenter Cohort Study

Author

Uijterwijk, Bas A., Lemmers, Daniël H., Ghidini, Michele, Wilmink, Hanneke, Zaniboni, Alberto, Salvia, Roberto, Kito Fusai, Giuseppe, Groot Koerkamp, Bas, Koek, Sharnice, Ghorbani, Poya, Zerbi, Alessandro, Nappo, Gennaro, Luyer, Misha, Goh, Brian K. P., Roberts, Keith J., Boggi, Ugo, Mavroeidis, Vasileios K., White, Steven, Kazemier, Geert, Björnsson, Bergthor, Serradilla-Martín, Mario, House, Michael G., Alseidi, Adnan, Ielpo, Benedetto, Mazzola, Michele, Jamieson, Nigel, Wellner, Ulrich, Soonawalla, Zahir, Cabús, Santiago Sánchez, Dalla Valle, Raffaele, Pessaux, Patrick, Vladimirov, Miljana, Kent, Tara S., Tang, Chung N., Fisher, William E., Kleeff, Jorg, Mazzotta, Alessandro, Suarez Muñoz, Miguel Angel, Berger, Adam C., Ball, Chad G., Korkolis, Dimitris, Bannone, Elisa, Ferarri, Clarissa, Besselink, Marc G., and Abu Hilal, Mohammed

Published
2024
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2. The road to tailored adjuvant chemotherapy for all four non-pancreatic periampullary cancers: An international multimethod cohort study

Author

Uijterwijk, Bas A., Lemmers, Daniël H., Ghidini, Michele, Wilmink, Johanna W., Zaniboni, Alberto, Fusai, Giuseppe Kito, Zerbi, Alessandro, Koerkamp, Bas Groot, Luyer, Misha, Ghorbani, Poya, Salvia, Roberto, White, Steven, Ielpo, Benedetto, Goh, Brian K. P., Boggi, Ugo, Kazemier, Geert, House, Michael G., Mavroeidis, Vasileios K., Björnsson, Bergthor, Mazzola, Michele, Serradilla, Mario, Korkolis, Dimitris, Alseidi, Adnan, Roberts, Keith J., Soonawalla, Zahir, Pessaux, Patrick, Fisher, William E., Koek, Sharnice, Kent, Tara S., Vladimirov, Miljana, Bolm, Louisa, Jamieson, Nigel, Dalla Valle, Raffaele, Kleeff, Jorg, Mazzotta, Alessandro, Suarez Muñoz, Miguel Angel, Cabús, Santiago Sánchez, Ball, Chad G., Berger, Adam C., Ferarri, Clarissa, Besselink, Marc G., and Hilal, Mohammed Abu

Published
2024
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3. Clickotine, A Personalized Smartphone App for Smoking Cessation: Initial Evaluation

Author

Iacoviello, Brian M, Steinerman, Joshua R, Klein, David B, Silver, Theodore L, Berger, Adam G, Luo, Sean X, and Schork, Nicholas J

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundTobacco smoking is the leading cause of preventable death in the United States, and the annual economic burden attributable to smoking exceeds US $300 billion. Obstacles to smoking cessation include limited access and adherence to effective cessation interventions. Technology can help overcome these obstacles; many smartphone apps have been developed to aid smoking cessation, but few that conform to the US clinical practice guideline (USCPG) have been rigorously tested and reported in the literature. Clickotine is a novel smartphone app for smoking cessation, designed to deliver the essential features of the USCPG and engineered to engage smokers by personalizing intervention components. ObjectiveOur objective was to assess the engagement, efficacy, and safety of Clickotine in an initial, single-arm study. Outcomes measured were indicators of engagement with the smartphone app (number of app opens, number of interactions with the Clickotine program, and weeks active with Clickotine), cessation outcomes of 7- and 30-day self-reported abstinence from smoking, and negative health events. MethodsWe recruited US residents between 18 and 65 years of age who owned an iPhone and smoked 5 or more cigarettes daily for the study via online advertising. Respondents were prescreened for eligibility by telephone and, if appropriate, directed to a Web portal to provide informed consent, confirm eligibility, and download the Clickotine app. Participants completed study assessments via the online portal at baseline and after 8 weeks. Data were collected in Amazon S3 with no manual data entry, and access to all data was maximally restrictive, logged, and auditable. ResultsA total of 416 participants downloaded the app and constituted the intention-to-treat (ITT) sample. On average, participants opened the Clickotine app 100.6 times during the 8-week study (median 69), logged 214.4 interactions with the Clickotine program (median 178), and remained engaged with Clickotine for 5.3 weeks (median 5). Among the ITT sample, 45.2% (188/416) reported 7-day abstinence and 26.2% (109/416) reported 30-day abstinence from smoking after 8 weeks. Completer analysis focused on 365 (87.7%) of the 416 enrolled participants who completed the 8-week questionnaire revealed that 51.5% (188/365) of completers reported 7-day abstinence and 29.9% (109/365) reported 30-day abstinence. Few adverse events, mostly consistent with nicotine withdrawal symptoms, were reported and overall no safety signal was detected. ConclusionsIn this initial single-arm trial, Clickotine users appeared to demonstrate encouraging indicators of engagement in terms of the number of app opens, number of program interactions, and continued engagement over time. Clickotine users reported encouraging quit rates while reporting few adverse events. Future research is warranted to assess Clickotine’s efficacy in a randomized controlled trial. Trial RegistrationClinicaltrials.gov NCT02656745; https://clinicaltrials.gov/ct2/show/NCT02656745 (Archived by WebCite at http://www.webcitation.org/6peTT4x60)

Published
2017
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4. Tackling challenges in rare diseases: The ISGACA approach on non-pancreatic cancers in the periampullary region

Author

Berger, Adam C., Alseidi, Adnan, Pisanu, Adolfo, Ramirez-Del Val, Alejandro, Serrablo, Alejandro, Anselmo, Alessandro, Ferrero, Alessandro, Giani, Alessandro, Mazzotta, Alessandro, Zerbi, Alessandro, Moekotte, Alma, Zureikat, Amer H., Cacciaguerra, Andrea Benedetti, de Wilde, Anouk, Koerkamp, Bas Groot, Ielpo, Bennedetto, Björnsson, Bergthor, Al, Bilal, Sarireh, Goh, Brian K.P., Gayet, Brice, Ball, Chad G., Vollmer, Charles M., Tang, Chung N., van Dam, Coen, Ricci, Claudio, Droogh, Daphne, Korkolis, Dimitris, Sparrelid, Ernesto, Ausania, Fabio, di Benedetto, Fabrizio, Lancelotti, Francesco, Berrevoet, Frederik, Kazemier, Geert, Nappo, Gennaro, Poya, Ghorbani, Marchegiani, Giovanni, Fusai, Giuseppe Kito, Malleo, Giuseppe, Seppanen, Hanna, Wilmink, Hanneke, Han, Ho-Seong, Frigerio, Isabella, Halle, James, Christein, John D., Kleeff, Jorg, de Vos Geelen, Judith, Johansen, Karin, Roberts, Keith J., Hayek, Kevin el, Khalil, Khalid, Webber, Laurence, Siragusa, Leandro, Bolm, Louisa, Maglione, Manuel, Ramaekers, Mark, Giuffrida, Mario, Gruppo, Mario, Serradilla, Mario, Ramaeckers, Mark, Fontana, Martina, Guerra, Martina, Dillhoff, Mary E., Mortimer, Matthew C.M., House, Michael G., Mazzola, Michele, Suarez Muñoz, Miguel Angel, Vladimirov, Miljana, Luyer, Misha, Bonds, Morgan, Kerem, Mustafa, Napoli, Niccolò, Mowbray, Nicholas, Jamieson, Nigel B., Soubrane, Olivier, Pessaux, Patrick, Mauro, Podda, Valle, Raffaele Dalla, Zheng, Richard, Casadei, Riccardo, Bhogal, Ricky, Salvia, Roberto, Salem, Ronald R., Cabús, Santiago Sánchez, Koek, Sharnice, Delis, Spiros, Bouwense, Stefan, Dreyer, Stephan, Behrman, Stephen W., White, Steven, Robinson, Stuart, Mieog, Sven, S.Kent, Tara, Vanagas, Tomas, Boggi, Ugo, Wellner, Ulrich, Mavroeidis, Vasileios K., Fisher, William E., Koh, Ye Xin, Soonawalla, Zahir, Uijterwijk, Bas A., Lemmers, Daniël H., Moekotte, Alma L., Zaniboni, Alberto, Ghidini, Michele, Milella, Michele, Scarpa, Aldo, Luchini, Claudio, Baboeram, Nigel, Klei, Dorine S., Manzoni, Alberto, Bannone, Elisa, Oneda, Ester, Besselink, Marc G., and Abu Hilal, Mohammed

Published
2024
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7. Intravitreal aflibercept 8 mg in diabetic macular oedema (PHOTON): 48-week results from a randomised, double-masked, non-inferiority, phase 2/3 trial

Author

Abraham, Prema, Aderman, Christopher, Akiyama, Kunihiko, Alfaro, Daniel V., Ali, Fareed A., Amini, Payam, Anzalotta, Andres Emanuelli, Bátor, György, Batlle, Ivan, Berger, Adam, Bhandari, Ramanath, Bridges, William, Brinkmann, Christian, Brown, Jamin, Burgess, Stuart, Calzada, Jorge, Capone Jr., Antonio, Cervena, Dana, Charles, Steven, Chaudhry, Nauman, Chow, David, Clark, W. Lloyd, Conrad III, Paul, Cunningham, Matthew, Dadgostar, Hajir, Dessouki, Amr, Deupree, Dana, Devine, Christopher, Eichenbaum, David, Ernest, Jan, Feltgen, Nicolas, Fenberg, Moss, Ferrone, Philip, Frenkel, Ronald, Friedman, Scott, Gasperini, Julie, Gerstenblith, Adam, Ghorayeb, Ghassan, Giunta, Michel, Goff, Mitchell, Golas, Liliya, Googe Jr., Joseph M., Goren Fein, Jordana, Hagedorn, Curtis, Hagiwara, Akira, Hahn, Paul, Hairston, Richard, Handza, Jason, Hau, Vivienne, Hayashi, Ken, Heier, Jeffrey, Hershberger, Vrinda, Higgins, Patrick, Hirano, Yoshio, Honda, Shigeru, Ikegami, Yasuko, Ishida, Yuichiro, Ishikawa, Isao, Ishii, Kiyoshi, Jablon, Eric P., Jain, Atul, Kaji, Yuichi, Kapoor, Kapil, Kerényi, Ágnes, Kimura, Kazuhiro, Kishino, Genichiro, Kiss, Katalin, Kitaoka, Takashi, Klancnik, James M., Kobayashi, Namie, Kogo, Jiro, Korda, Vladimir, Kruger, Erik, Kusuhara, Sentaro, Lara, Wilfredo, Laud, Ketan, Lee, Seong, Luu, James, Marcus, Dennis, Mein, Calvin, Meleth, Annal, Milibák, Tibor, Mitamura, Yoshinori, Murata, Toshinori, Noge, Sumiyo, Onoe, Hajime, Osher, James, Papp, András, Parschauer, Justin, Patel, Sugat, Patel, Sunil, Pezda, Matthew, Pirouz, Ashkan, Prasad, Pradeep, Punjabi, Omar, Rao, Llewelyn, Roe, Richard, Schadlu, Ramin, Schneider, Eric, Shah, Ankur, Shah, Milan, Shah, Sandeep, Shah, Sumit, Sharma, Ashish, Sheth, Veeral, Shimura, Masahiko, Singerman, Lawrence, Spital, Georg, Stoltz, Robert, Suan, Eric, Suzuma, Kiyoshi, Takahashi, Hidenori, Takamura, Yoshihiro, Takeuchi, Masaru, Tan, Jeffrey, Thomas, Benjamin, Tóth,-Molnár, Edit, Ueda, Tetsuo, Ushida, Hiroaki, Vajas, Attila, Varma, Deepali, Varsányi, Balázs, Veith, Miroslav, Weber, Pamela, Wee, Raymond, Williams, Geoff, Yamada, Haruhiko, Yonekawa, Yoshihiro, Yoshida, Shigeo, Brown, David M, Boyer, David S, Do, Diana V, Wykoff, Charles C, Sakamoto, Taiji, Win, Peter, Joshi, Sunir, Salehi-Had, Hani, Seres, András, Berliner, Alyson J, Leal, Sergio, Vitti, Robert, Chu, Karen W, Reed, Kimberly, Rao, Rohini, Cheng, Yenchieh, Sun, Wei, Voronca, Delia, Bhore, Rafia, Schmidt-Ott, Ursula, Schmelter, Thomas, Schulze, Andrea, Zhang, Xin, Hirshberg, Boaz, Yancopoulos, George D, and Sivaprasad, Sobha

Published
2024
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8. Tumor lysate particle only vaccine (TLPO) vs. Tumor lysate particle-loaded, dendritic cell vaccine (TLPLDC) to prevent recurrence in resected stage III/IV melanoma patients: Results of a phase I/IIa trial

Author

Van Decar, Spencer G., Carpenter, Elizabeth L., Adams, Alexandra M., Chick, Robert C., Clifton, Guy T., Stojadinovic, Alex, Vreeland, Timothy J., Valdera, Franklin A., Tiwari, Ankur, O'Shea, Anne E., McCarthy, Patrick M., Hale, Diane F., Bohan, Phillip M Kemp, Hickerson, Annelies T., Cindass, Jessica L., Hyngstrom, John, Berger, Adam C., Jakub, James W., Sussman, Jeffrey J., Shaheen, Montaser, Yu, Xianzhong, Wagner, Thomas, Faries, Mark B., and Peoples, George E.

Published
2024
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9. Divergent clinical outcomes in a phase 2B trial of the TLPLDC vaccine in preventing melanoma recurrence and the impact of dendritic cell collection methodology: a randomized clinical trial

Author

Adams, Alexandra M., Carpenter, Elizabeth L., Clifton, Guy T., Vreeland, Timothy J., Chick, Robert C., O’Shea, Anne E., McCarthy, Patrick M., Kemp Bohan, Phillip M., Hickerson, Annelies T., Valdera, Franklin A., Tiwari, Ankur, Hale, Diane F., Hyngstrom, John R., Berger, Adam C., Jakub, James W., Sussman, Jeffrey J., Shaheen, Montaser F., Yu, Xianzhong, Wagner, Thomas E., Faries, Mark B., and Peoples, George E.

Published
2023
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11. Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee

Author

Gastman, Brian, Agarwal, Piyush K, Berger, Adam, Boland, Genevieve, Broderick, Stephen, Butterfield, Lisa H, Byrd, David, Fecci, Peter E, Ferris, Robert L, Fong, Yuman, Goff, Stephanie L, Grabowski, Matthew M, Ito, Fumito, Lim, Michael, Lotze, Michael T, Mahdi, Haider, Malafa, Mokenge, Morris, Carol D, Murthy, Pranav, Neves, Rogerio I, Odunsi, Adekunle, Pai, Sara I, Prabhakaran, Sangeetha, Rosenberg, Steven A, Saoud, Ragheed, Sethuraman, Jyothi, Skitzki, Joseph, Slingluff, Craig L, Sondak, Vernon K, Sunwoo, John B, Turcotte, Simon, Yeung, Cecilia CS, and Kaufman, Howard L

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Immunization, Rare Diseases, Cancer, Clinical Research, Clinical Trials and Supportive Activities, Orphan Drug, Detection, screening and diagnosis, 4.5 Resources and infrastructure (detection), Good Health and Well Being, Clinical Trials as Topic, Humans, Immunotherapy, Medical Oncology, Tissue and Organ Procurement, biomarkers, tumor, guidelines as topic, review, clinical trials as topic, immunotherapy, Oncology and carcinogenesis
Abstract

Immunotherapy is now a cornerstone for cancer treatment, and much attention has been placed on the identification of prognostic and predictive biomarkers. The success of biomarker development is dependent on accurate and timely collection of biospecimens and high-quality processing, storage and shipping. Tumors are also increasingly used as source material for the generation of therapeutic T cells. There have been few guidelines or consensus statements on how to optimally collect and manage biospecimens and source material being used for immunotherapy and related research. The Society for Immunotherapy of Cancer Surgery Committee has brought together surgical experts from multiple subspecialty disciplines to identify best practices and to provide consensus on how best to access and manage specific tissues for immuno-oncology treatments and clinical investigation. In addition, the committee recommends early integration of surgeons and other interventional physicians with expertise in biospecimen collection, especially in clinical trials, to optimize the quality of tissue and the validity of correlative clinical studies in cancer immunotherapy.

Published
2020

13. Changes To Illinois Biometric Data Law Lower Liability, But The Stakes Remain High

Author

Berger, Adam

Subjects
Privacy, Right of -- Laws, regulations and rules, Online gambling -- Laws, regulations and rules, Data security -- Laws, regulations and rules, Government regulation, Sports/gambling game, Biometric technology, Data security issue, Business, international
Abstract

In recent years, a heavy question mark has weighed on companies that process biometric information as part of their standard operating procedures: What is our risk exposure? In a previous [...]

Published
2024

18. A risk-adjusted analysis of drain use in pancreaticoduodenectomy: Some is good, but more may not be better

Author

Brubaker, Lisa S., Casciani, Fabio, Fisher, William E., Wood, Amy L., Cagigas, Martha Navarro, Trudeau, Maxwell T., Parikh, Viraj J., Baugh, Katherine A., Asbun, Horacio J., Ball, Chad G., Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Christein, John D., Fernandez-del Castillo, Carlos, Dillhoff, Mary E., Dixon, Elijah, House, Michael G., Hughes, Steven J., Kent, Tara S., Kunstman, John W., Wolfgang, Christopher L., Zureikat, Amer H., Vollmer, Charles M., Jr., and Van Buren, George, II

Published
2022
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19. Resource requirements to accelerate clinical applications of next-generation sequencing and radiomics: workshop commentary and review.

Author

Harris, Lyndsay, Shankar, Lalitha K, Hildebrandt, Claire, Rubinstein, Wendy S, Langlais, Kristofor, Rodriguez, Henry, Berger, Adam, Freymann, John, Huang, Erich P, Williams, P Mickey, Zenklusen, Jean Claude, Ochs, Robert, Tezak, Zivana, and Sahiner, Berkman

Subjects
NUCLEOTIDE sequencing, ARTIFICIAL intelligence, MACHINE learning, RADIOMICS, SCIENTIFIC community
Abstract

The National Institutes of Health–US Food and Drug Administration Joint Leadership Council Next-Generation Sequencing and Radiomics Working Group was formed by the National Institutes of Health–Food and Drug Administration Joint Leadership Council to promote the development and validation of innovative next-generation sequencing tests, radiomic tools, and associated data analysis and interpretation enhanced by artificial intelligence and machine learning technologies. A 2-day workshop was held on September 29-30, 2021, to convene members of the scientific community to discuss how to overcome the "ground truth" gap that has frequently been acknowledged as 1 of the limiting factors impeding high-quality research, development, validation, and regulatory science in these fields. This report provides a summary of the resource gaps identified by the working group and attendees, highlights existing resources and the ways they can potentially be employed to accelerate growth in these fields, and presents opportunities to support next-generation sequencing and radiomic tool development and validation using technologies such as artificial intelligence and machine learning. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Prognostic value of coronary computed tomographic angiography findings in asymptomatic individuals: a 6-year follow-up from the prospective multicentre international CONFIRM study.

Author

Cho, Iksung, Al'Aref, Subhi J, Berger, Adam, Ó Hartaigh, Bríain, Gransar, Heidi, Valenti, Valentina, Lin, Fay Y, Achenbach, Stephan, Berman, Daniel S, Budoff, Matthew J, Callister, Tracy Q, Al-Mallah, Mouaz H, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin JW, DeLago, Augustin, Villines, Todd C, Hadamitzky, Martin, Hausleiter, Joerg, Leipsic, Jonathon, Shaw, Leslee J, Kaufmann, Philipp A, Feuchtner, Gudrun, Kim, Yong-Jin, Maffei, Erica, Raff, Gilbert, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Chang, Hyuk-Jae, and Min, James K

Subjects
Heart Disease - Coronary Heart Disease, Cardiovascular, Heart Disease, Biomedical Imaging, Atherosclerosis, Clinical Research, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Adult, Aged, Asymptomatic Diseases, Coronary Angiography, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Tomography, X-Ray Computed, Vascular Calcification, Coronary artery calcium scoring, Coronary CT angiography, Coronary artery disease, Computed tomography, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology
Abstract

Aim:The long-term prognostic benefit of coronary computed tomographic angiography (CCTA) findings of coronary artery disease (CAD) in asymptomatic populations is unknown. Methods and results:From the prospective multicentre international CONFIRM long-term study, we evaluated asymptomatic subjects without known CAD who underwent both coronary artery calcium scoring (CACS) and CCTA (n = 1226). Coronary computed tomographic angiography findings included the severity of coronary artery stenosis, plaque composition, and coronary segment location. Using the C-statistic and likelihood ratio tests, we evaluated the incremental prognostic utility of CCTA findings over a base model that included a panel of traditional risk factors (RFs) as well as CACS to predict long-term all-cause mortality. During a mean follow-up of 5.9 ± 1.2 years, 78 deaths occurred. Compared with the traditional RF alone (C-statistic 0.64), CCTA findings including coronary stenosis severity, plaque composition, and coronary segment location demonstrated improved incremental prognostic utility beyond traditional RF alone (C-statistics range 0.71-0.73, all P  0.05, for all). Conclusions:Coronary computed tomographic angiography improved prognostication of 6-year all-cause mortality beyond a set of conventional RF alone, although, no further incremental value was offered by CCTA when CCTA findings were added to a model incorporating RF and CACS.

Published
2018

23. Tumor Lysate Particle Only Vaccine (TLPO) vs. Tumor Lysate Particle-Loaded, Dendritic Cell Vaccine (TLPLDC) to Prevent Recurrence in Resected Stage III/IV Melanoma Patients: Results of a Phase I/IIa Trial

Author

Decar, Spencer G. Van, primary, Carpenter, Elizabeth L., additional, Adams, Alexandra M., additional, Chick, Robert C., additional, Clifton, Guy T., additional, Stojadinovic, Alex, additional, Vreeland, Timothy J., additional, Valdera, Franklin A., additional, Tiwari, Ankur, additional, O’Shea, Anne E., additional, McCarthy, Patrick M., additional, Hale, Diane F., additional, Bohan, Phillip M Kemp, additional, Hickerson, Annelies T., additional, Cindass, Jessica L., additional, Hyngstrom, John, additional, Berger, Adam C., additional, Jakub, James W., additional, Sussman, Jeffrey J., additional, Shaheen, Montaser, additional, Yu, Xianzhong, additional, Wagner, Thomas, additional, Faries, Mark, additional, and Peoples, George, additional

Published
2024
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24. The effect of high intraoperative blood loss on pancreatic fistula development after pancreatoduodenectomy: An international, multi-institutional propensity score matched analysis

Author

Fisher, William E., Van Buren, George, II, Callery, Mark P., Kent, Tara S., Pratt, Wande B., Vollmer, Charles M., Jr., Watkins, Ammara A., House, Michael G., Beane, Joal D., Berger, Adam C., Wolfgang, Christopher L., Javed, Ammar A., Poruk, Katherine E., Soares, Kevin C., Valero, Vicente, III, Fernandez-del Castillo, Carlos, Fong, Zhi V., Asbun, Horacio J., Stauffer, John A., Bloomston, Mark P., Dilhoff, Mary E., Haverick, Ericka N., Schmidt, Carl R., Christein, John D., Hollis, Robert H., Ball, Chad G., Dixon, Elijah, Hughes, Steven J., Drebin, Jeffrey A., Ecker, Brett, Lewis, Russell, Jr., McMillan, Matthew, Miller, Benjamin, Puri, Priya, Seykora, Thomas, Sprys, Michael J., Zureikat, Amer H., Kowalsky, Stacy J., Behrman, Stephen W., Bassi, Claudio, Casciani, Fabio, Maggino, Laura, Malleo, Giuseppe, Salvia, Roberto, Savegnago, Giulia, Cinelli, Lorenzo, Falconi, Massimo, Partelli, Stefano, Dickson, Euan J., Jamieson, Nigel B., Velu, Lavanniya K.P., Salem, Ronald R., Kunstman, John W., Trudeau, Maxwell T., Dillhoff, Mary E., and Vollmer, Charles M.

Published
2021
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25. A Phase IIb Randomized Controlled Trial of the TLPLDC Vaccine as Adjuvant Therapy After Surgical Resection of Stage III/IV Melanoma: A Primary Analysis

Author

Vreeland, Timothy J., Clifton, Guy T., Hale, Diane F., Chick, Robert C., Hickerson, Annelies T., Cindass, Jessica L., Adams, Alexandra M., Bohan, Phillip M. Kemp, Andtbacka, Robert H. I., Berger, Adam C., Jakub, James W., Sussman, Jeffrey J., Terando, Alicia M., Wagner, Thomas, Peoples, George E., and Faries, Mark B.

Published
2021
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27. Impact of Cavity Shave Margins on Margin Status in Patients with Pure Ductal Carcinoma In Situ

Author

Howard-McNatt, Marissa, Dupont, Elisabeth, Tsangaris, Theodore, Garcia-Cantu, Carlos, Chiba, Akiko, Berger, Adam C., Levine, Edward A., Gass, Jennifer S., Ollila, David W., Gallagher, Kristalyn, Lum, Sharon S., Martinez, Ricardo D., Willis, Alliric I., Pandya, Sonali V., Brown, Eric A., Fenton, Andrew, Mendiola, Amanda, Murray, Mary, Haddad, Victor, Solomon, Naveenraj L., Senthil, Maheswari, Bansil, Hannah, Snyder, Samuel K., Edmonson, David, Lazar, Melissa, Namm, Jukes P., Li, Fangyong, Butler, Meghan, McGowan, Noreen E., Herrera, Maria E., Avitan, Yoana P., Yoder, Brian, McPartland, Tara, and Chagpar, Anees B.

Published
2021
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28. Surgeon experience contributes to improved outcomes in pancreatoduodenectomies at high risk for fistula development

Author

Fisher, William E., Van Buren, George, II, Callery, Mark P., Kent, Tara S., Pratt, Wande B., Vollmer, Charles M., Jr., Watkins, Ammara A., House, Michael G., Beane, Joal D., Berger, Adam C., Wolfgang, Christopher L., Javed, Ammar A., Poruk, Katherine E., Soares, Kevin C., Valero, Vicente, III, Fernandez-del Castillo, Carlos, Fong, Zhi V., Asbun, Horacio J., Stauffer, John A., Bloomston, Mark P., Dilhoff, Mary E., Haverick, Ericka N., Schmidt, Carl R., Christein, John D., Hollis, Robert H., Ball, Chad G., Dixon, Elijah, Hughes, Steven J., Drebin, Jeffrey A., Ecker, Brett, Lewis, Russell, Jr., McMillan, Matthew, Miller, Benjamin, Puri, Priya, Seykora, Thomas, Sprys, Michael J., Zureikat, Amer H., Kowalsky, Stacy J., Behrman, Stephen W., Bassi, Claudio, Casciani, Fabio, Maggino, Laura, Malleo, Giuseppe, Salvia, Roberto, Savegnago, Giulia, Cinelli, Lorenzo, Falconi, Massimo, Partelli, Stefano, Dickson, Euan J., Jamieson, Nigel B., Velu, Lavanniya K.P., Salem, Ronald R., Kunstman, John W., Trudeau, Maxwell T., and Dillhoff, Mary E.

Published
2021
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29. Controlling Cooperative CO2 Adsorption in Diamine-Appended Mg2(dobpdc) Metal–Organic Frameworks

Author

Siegelman, Rebecca L, McDonald, Thomas M, Gonzalez, Miguel I, Martell, Jeffrey D, Milner, Phillip J, Mason, Jarad A, Berger, Adam H, Bhown, Abhoyjit S, and Long, Jeffrey R

Subjects
Inorganic Chemistry, Engineering, Chemical Sciences, Climate Action, Adsorption, Carbon Dioxide, Coordination Complexes, Crystallography, X-Ray, Diamines, Magnesium, Metal-Organic Frameworks, Models, Molecular, Molecular Structure, Surface Properties, General Chemistry, Chemical sciences
Abstract

In the transition to a clean-energy future, CO2 separations will play a critical role in mitigating current greenhouse gas emissions and facilitating conversion to cleaner-burning and renewable fuels. New materials with high selectivities for CO2 adsorption, large CO2 removal capacities, and low regeneration energies are needed to achieve these separations efficiently at scale. Here, we present a detailed investigation of nine diamine-appended variants of the metal-organic framework Mg2(dobpdc) (dobpdc4- = 4,4'-dioxidobiphenyl-3,3'-dicarboxylate) that feature step-shaped CO2 adsorption isotherms resulting from cooperative and reversible insertion of CO2 into metal-amine bonds to form ammonium carbamate chains. Small modifications to the diamine structure are found to shift the threshold pressure for cooperative CO2 adsorption by over 4 orders of magnitude at a given temperature, and the observed trends are rationalized on the basis of crystal structures of the isostructural zinc frameworks obtained from in situ single-crystal X-ray diffraction experiments. The structure-activity relationships derived from these results can be leveraged to tailor adsorbents to the conditions of a given CO2 separation process. The unparalleled versatility of these materials, coupled with their high CO2 capacities and low projected energy costs, highlights their potential as next-generation adsorbents for a wide array of CO2 separations.

Published
2017

31. The Influence of Intraoperative Blood Loss on Fistula Development Following Pancreatoduodenectomy

Author

Trudeau, Maxwell T., Casciani, Fabio, Maggino, Laura, Seykora, Thomas F., Asbun, Horacio J., Ball, Chad G., Bassi, Claudio, Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Castillo, Carlos Fernandez-del, Christein, John D., Dillhoff, Mary E., Dickson, Euan J., Dixon, Elijah, Fisher, William E., House, Michael G., Hughes, Steven J., Kent, Tara S., Malleo, Giuseppe, Salem, Ronald R., Wolfgang, Christopher L., Zureikat, Amer H., and Vollmer, Charles M.

Published
2022
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34. Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma

Author

Moekotte, Alma L., van Roessel, Stijn, Malleo, Giuseppe, Rajak, Rushda, Ecker, Brett L., Fontana, Martina, Han, Ho-Seong, Rabie, Mohamed, Roberts, Keith J., Khalil, Khalid, White, Steven A., Robinson, Stuart, Halimi, Asif, Zarantonello, Laura, Fusai, Giuseppe K., Gradinariu, George, Alseidi, Adnan, Bonds, Morgan, Dreyer, Stephan, Jamieson, Nigel B., Mowbray, Nicholas, Al-Sarireh, Bilal, Mavroeidis, Vasileios K., Soonawalla, Zahir, Napoli, Niccolò, Boggi, Ugo, Kent, Tara S., Fisher, William E., Tang, Chung N., Bolm, Louisa, House, Michael G., Dillhoff, Mary E., Behrman, Stephen W., Nakamura, Masafumi, Ball, Chad G., Berger, Adam C., Christein, John D., Zureikat, Amer H., Salem, Ronald R., Vollmer, Charles M., Salvia, Roberto, Besselink, Marc G., Abu Hilal, Mohammed, Aljarrah, Ra'ed, Barrows, Courtney, Cagigas, Martha Navarro, Lai, Eric C.H., Wellner, Ulrich, Aversa, John, Dickson, Paxton V., Ohtsuka, Takao, Dixon, Elijah, Zheng, Richard, Kowalski, Stacy, and Freedman-Weiss, Mollie

Published
2020
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38. Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors

Author

Wang, Chun, Mu, Zhaomei, Ye, Zhong, Zhang, Zhenchao, Abu-Khalaf, Maysa M., Silver, Daniel P., Palazzo, Juan P., Jagannathan, Geetha, Fellin, Frederick M., Bhattacharya, Saveri, Jaslow, Rebecca J., Tsangaris, Theodore N., Berger, Adam, Neupane, Manish, Cescon, Terrence P., Lopez, AnaMaria, Yao, Kaelan, Chong, Weelic, Lu, Brian, Myers, Ronald E., Hou, Lifang, Wei, Qiang, Li, Bingshan, Cristofanilli, Massimo, and Yang, Hushan

Published
2020
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44. Novel Form of Breast Intraoperative Radiation Therapy with CT-Guided High-Dose-Rate Brachytherapy: Interim Results of a Prospective Phase-II Clinical Trial

Author

Turkheimer, Lena M, primary, Petroni, Gina R, additional, Berger, Adam C, additional, Schroen, Anneke T, additional, Brenin, David R, additional, Lazar, Melissa, additional, Libby, Bruce, additional, Janowski, Einsley M, additional, Showalter, Timothy N, additional, and Showalter, Shayna L, additional

Published
2023
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47. The Influence of Intraoperative Blood Loss on Fistula Development Following Pancreatoduodenectomy

Author

Trudeau, Maxwell T., Casciani, Fabio, Maggino, Laura, Seykora, Thomas F., Asbun, Horacio J., Ball, Chad G., Bassi, Claudio, Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Castillo, Carlos Fernandez-del, Christein, John D., Dillhoff, Mary E., Dickson, Euan J., Dixon, Elijah, Fisher, William E., House, Michael G., Hughes, Steven J., Kent, Tara S., Malleo, Giuseppe, Salem, Ronald R., Wolfgang, Christopher L., Zureikat, Amer H., and Vollmer, Charles M.

Published
2020
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48. The Fistula Risk Score Catalog: Toward Precision Medicine for Pancreatic Fistula After Pancreatoduodenectomy

Author

Trudeau, Maxwell T., Casciani, Fabio, Ecker, Brett L., Maggino, Laura, Seykora, Thomas F., Puri, Priya, McMillan, Matthew T., Miller, Benjamin, Pratt, Wande B., Asbun, Horacio J., Ball, Chad G., Bassi, Claudio, Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Castillo, Carlos Fernandez-del, Christein, John D., Dillhoff, Mary E., Dickson, Euan J., Dixon, Elijah, Fisher, William E., House, Michael G., Hughes, Steven J., Kent, Tara S., Malleo, Giuseppe, Salem, Ronald R., Wolfgang, Christopher L., Zureikat, Amer H., and Vollmer, Charles M.

Published
2020
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49. Resection of Cavity Shave Margins in Stage 0–III Breast Cancer Patients Undergoing Breast Conserving Surgery: A Prospective Multicenter Randomized Controlled Trial

Author

Dupont, Elisabeth, Tsangaris, Theodore, Garcia-Cantu, Carlos, Howard-McNatt, Marissa, Chiba, Akiko, Berger, Adam C., Levine, Edward A., Gass, Jennifer S., Gallagher, Kristalyn, Lum, Sharon S., Martinez, Ricardo D., Willis, Alliric I., Pandya, Sonali V., Brown, Eric A., Fenton, Andrew, Mendiola, Amanda, Murray, Mary, Solomon, Naveenraj L., Senthil, Maheswari, Ollila, David W., Edmonson, David, Lazar, Melissa, Namm, Jukes P., Li, Fangyong, Butler, Meghan, McGowan, Noreen E., Herrera, Maria E., Avitan, Yoana P., Yoder, Brian, Walters, Laura L., McPartland, Tara, and Chagpar, Anees B.

Published
2021
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