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2. A Decentralized Policy with Logarithmic Regret for a Class of Multi-Agent Multi-Armed Bandit Problems with Option Unavailability Constraints and Stochastic Communication Protocols

Author

Pankayaraj, Pathmanathan, Maithripala, D. H. S., and Berg, J. M.

Subjects
Computer Science - Machine Learning, Mathematics - Statistics Theory, Statistics - Machine Learning
Abstract

This paper considers a multi-armed bandit (MAB) problem in which multiple mobile agents receive rewards by sampling from a collection of spatially dispersed stochastic processes, called bandits. The goal is to formulate a decentralized policy for each agent, in order to maximize the total cumulative reward over all agents, subject to option availability and inter-agent communication constraints. The problem formulation is motivated by applications in which a team of autonomous mobile robots cooperates to accomplish an exploration and exploitation task in an uncertain environment. Bandit locations are represented by vertices of the spatial graph. At any time, an agent's option consist of sampling the bandit at its current location, or traveling along an edge of the spatial graph to a new bandit location. Communication constraints are described by a directed, non-stationary, stochastic communication graph. At any time, agents may receive data only from their communication graph in-neighbors. For the case of a single agent on a fully connected spatial graph, it is known that the expected regret for any optimal policy is necessarily bounded below by a function that grows as the logarithm of time. A class of policies called upper confidence bound (UCB) algorithms asymptotically achieve logarithmic regret for the classical MAB problem. In this paper, we propose a UCB-based decentralized motion and option selection policy and a non-stationary stochastic communication protocol that guarantee logarithmic regret. To our knowledge, this is the first such decentralized policy for non-fully connected spatial graphs with communication constraints. When the spatial graph is fully connected and the communication graph is stationary, our decentralized algorithm matches or exceeds the best reported prior results from the literature., Comment: Pre-print submitted for review to the 2020 CDC

Published
2020

3. A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study

Author

Jackson, Heather Ruth, Zandstra, Judith, Menikou, Stephanie, Hamilton, Shea, McArdle, Andrew J, De, Tisham, Agyeman, Philipp K A, Von Both, Ulrich, Carrol, Enitan D, Emonts, Marieke, Eleftheriou, Irini, Van der Flier, Michiel, Fink, Colin, De Groot, Ronald, Moll, Henriette A, Pokorn, Marko, Pollard, Andrew, Schlapbach, Luregn J, Tsolia, Maria, Usuf, Effua, Wright, Victoria, Yeung, Shunmay, Zavadska, Dace, Zenz, Werner, Coin, Lachlan JM, Cunnington, Aubrey J, Martinon-Torres, Federico, Herberg, Jethro, De Jonge, Marien I, Levin, Michael, Kuijpers, Taco, Kaforou, Myrsini, Abdulla, Amina, Aebi, Christoph, Agbeko, Rachel, Ali, Ladan, Alkema, Wynand, Allen, Karen, Anderson, Suzanne, Ansari, Imran, Arif, Tasnim, Avramoska, Tanja, Baas, Bryan, Bahovec, Natalija, Balode, Anda, Bãrdzdina, Arta, Barendregt, A M, Barral-Arca, Ruth, Bath, David, Bauchinger, Sebastian, Baumard, Lucas, Baumgart, Hinrich, Baxter, Frances, Bell, Kathryn, Bell, Ashley, Bello, Xabier, Bellos, Evangelos, Benesch, Martin, Bennet, Joshua, Berger, Christoph, Bernhard-Stirnemann, Sara, Bibi, Sagida, Bidlingmaier, Christoph, Binder, Alexander, Binder, Vera, Blackmore, Jennifer, Bojang, Kalifa, Borensztajn, Dorine M, Brengel-Pesce, Karen, Broderick, Claire, Buschbeck, Judith, Calvo-Bado, Leonides, Carnota, Sandra, Carter, Michael J, Castro, María Barreiro, Cebey-López, Miriam, Ceesay, Samba, Ceolotto, Astrid, Chan, Adora, Cocklin, Elizabeth, Collings, Kalvin, Crulley, Stephen, Curras-Tuala, María José, D'alessandro, Umberto, D'Souza, Giselle, Danhauser, Katharina, Darboe, Saffiatou, Darnell, Sarah, De Haan, L, De Vries, Gabriella, Deksne, Dãrta, Devine, Kirsty, Dewez, Juan Emmanuel, Dik, W, Dudley, Julia, Eber, Ernst, Fabian, Daniel, Farto, Cristina Balo, Fernández, Sonia Serén, Fidler, Katy, Fitchett, Elizabeth, Galassini, Rachel, Gallisti, Siegfried, García, Mirian Ben, Gardovska, Dace, Geissler, J, Gerrits, G P J M, Giannoni, Eric, Gloerich, Jolein, Gómez-Carballa, Alberto, González, Fernando Álves, Gores, Gunther, Grãvele, Dagne, Griese, Matthias, Grope, Ilze, Gurung, Meeru, Haas, Nikolaus, Habgood-Coote, Dominic, Hagedoorn, Nienke N, Haidl, Harald, Harrison, Rebekah, Hauer, Almuthe, Heidema, J, Heininger, Ulrich, Henriet, Stefanie, Hibberd, Martin, Hoggart, Cllive, Hösele, Susanne, Hourmat, Sara, Hude, Christa, Huijnen, Martijn, Iglesias, Pilar Leboráns, Iglesias, Marisol Vilas, Jennings, Rebecca, Johnson, Joanne, Jongerius, Ilse, Jorgensen, Rikke, Kahlert, Christian, Kandasamy, Rama, Kappler, Matthias, Keldorfer, Markus, Kelly, Dominic F, Khanijau, Aakash, Kim, Nayoung, Kim, Eunjung, King, Sharon, Kolberg, Laura, Kolnik, Mojca, Kloosterhuis, Lieke, Kohlfürst, Daniela S, Kohlmaier, Benno, Krenn, Larissa, Leigh, Simon, Leitner, Manuel, Leurent, Baptiste, Lim, Emma, Lin, Naomi, Liu, Ching-Chuan, Löffler, Sabine, Lurz, Eberhard, Mackerness, Christine, Maconochie, Ian, Mallet, Francois, Marmarinos, Antonis, Martin, Alex, Martin, Mike, Martinón Sánchez, José María, Martinón-Torres, Nazareth, McAlinden, Paul, McDonald, Sam, McDonell, Anne, Meiere, Anija, Meierford, Anne, Miedema, C J, Miners, Alec, Mistry, Ravi, Mommert, Marine, Morris, Sophie, Muench, Georg, Murdoch, David R, Mustafa, Sobia, Natalucci, Giancarlo, Neeleman, C, Newall, Karen, Nichols, Samuel, Niederer-Loher, Anita, Niedrist, Tobias, Nijman, Ruud, Nokalna, Ieve, Nordberg, Gudrun, O'Connor, Daniel, Obihara, C C, Oliver, Zoe, Oosthoek, Wilma, Ora, Miguel Sadiki, Osterman, Veronika, Pachot, Alexandre, Pajkrt, D, Pardo-Seco, Jacobo, Pavãre, Jana, Paz, Ivonne Pena, Paulus, Stéphane, Pérez, Belén Mosquera, Persand, Salina, Pfleger, Andreas, Pfurtscheller, Klaus, Philipsen, Ria, Pickering, Alisa, Pierce, Benjamin, Pilch, Heidemarie, Pischedda, Sara, Pölz, Lena, Posfay-Barbe, Klara M, Powell, Oliver, Prunk, Petra, Pučuka, Zanda, Rajic, Glorija, Rashid, Aqeela, Redondo-Collazo, Lorenzo, Reiter, Karl, Relly, Christa, Rhodes, Mathew, Rial, Jose Gómez, Richmond, Vivien, Riedel, Thomas, Rivero Calle, Irene, Roca, Anna, Rödl, Siegfried, Rodríguez, Lidia Piñeiro, Rodríguez-Tenreiro, Carmen, Romaine, Sam, Rowlands, Emily, Rudzate, Aleksandra, Sagmeister, Manfred, Saidykhan, Momodou, Sallas, Antonio, Sarr, Isatou, Schoen, Carola, Schonenberg, D, Schweintzger, Nina, Secka, Fatou, Selecka, Katrīna, Shah, Priyen, Shen, Ching-Fen, Shrestha, Shrijana, Skrabl-Baumgartner, Andrea, Soon, Joshua, Sperl, Matthias, Sprenkeler, Evelien, Spyridis, Nikos, Srovin, Tina Plankar, Stampfer, Laura, Stevens, Molly, Stocker, Martin, Strenger, Volker, Suárez, Carlos Durán, Svile, Dace, Syggelou, Kelly, Tal, Chantal, Tambouratzi, Maria, Tavliavini, Emma, Thakker, Clare, Thomson, Evelyn, Throson, Stephen, Till, Holger, Tramper-Stranders, G A, Trasorras, Cristina Serén, Trobisch, Andreas, Urbãne, Urzula Nora, Usman, Mariama, Valentine, Lucille, Van Aerde, Koen, Van den Berg, J M, Van den Broek, Bryan, Van der Giessen, Ilona, Van der Kuip, M, Van der Velden, Fabian, Van Furth, A M, Van Gool, Alain J, Van Leur, M, van Mierlo, G, Vázquez, Sara Ray, Vermont, Clementien, Vicente, Luisa García, Vincek, Katarina, Vito, Ortensia, Voice, Marie, Wallia, Diane, Walsh, Ben, Wang, Shih-Min, Wedderburn, Catherine, Willems, Esther, Wilson, Clare, Wood, Amanda, Woodsford, Phil, Wyss, Verena, Xagorari, Marietta, Zachariasse, Joany, Zaman, Syed M A, Zurl, Christoph, Zwerenz, Manuela, Jackson, Heather R, Hamilton, Melissa Shea, Fischer, Roman, Thorne, Adam M, Huang, Honglei, Tanck, Michael W, Jansen, Machiel H, Pollard, Andrew J, Tsolia, Maria N, Wright, Victoria J, Coin, Lachlan J M, Casals-Pascual, Climent, Herberg, Jethro A, de Jonge, Marien I, and Kuijpers, Taco W

Published
2023
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5. Feedback Regularization and Geometric PID Control for Robust Stabilization of a Planar Three-link Hybrid Bipedal Walking Model

Author

Weerakoon, W. M. L. T., Madhushani, T. W. U., Maithripala, D. H. S., and Berg, J. M.

Subjects
Electrical Engineering and Systems Science - Systems and Control, Computer Science - Robotics
Abstract

This paper applies a recently developed geometric PID controller to stabilize a three-link planar bipedal hybrid dynamic walking model. The three links represent the robot torso and two kneeless legs, with an independent control torque available at each hip joint. The geometric PID controller is derived for fully actuated mechanical systems, however in the swing phase the three-link biped robot has three degrees of freedom and only two controls. Following the bipedal walking literature, underactuation is addressed by choosing two "virtual constraints" to enforce, and verifying the stability of the resulting two-dimensional zero dynamics. The resulting controlled dynamics do not have the structure of a mechanical system, however this structure is restored using "feedback regularization," following which geometric PID control is used to provide robust asymptotic regulation of the virtual constraints. The proposed method can tolerate significantly greater variations in inclination, showing the value of the geometric methods, and the benefit of integral action., Comment: Preprint submitted to 2018 American Control Conference

Published
2017
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8. 2020 ESC Guidelines on acute coronary syndrome without ST-segment elevation: Recommendations and critical appraisal from the Dutch ACS and Interventional Cardiology working groups

Author

Arslan, F., Damman, P., Zwart, B., Appelman, Y., Voskuil, M., de Vos, A., van Royen, N., Jukema, J. W., Waalewijn, R., Hermanides, R. S., Woudstra, P., ten Cate, T., Lemkes, J. S., Vink, M. A., Balder, W., van der Wielen, M. L. J., Vlaar, P. J., van der Heijden, D. J., Assa, S., van ’t Hof, A. W., and ten Berg, J. M.

Published
2021
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10. A Geometric PID Control Framework for Mechanical Systems

Author

Maithripala, D. H. S., Madhushani, T. W. U., and Berg, J. M.

Subjects
Mathematics - Optimization and Control
Abstract

These lectures demonstrate the development of a PID control framework for mechanical systems. Based on the observation that mechanical systems are essentially double integrator systems, we generalize the linear PID controller to mechanical systems that have a non-Euclidean configuration space. Specifically we start by presenting the development of the geometric PID controller for fully actuated mechanical systems and then extend it to a class of under actuated interconnected mechanical systems of practical significance by introducing the notion of feedback regularization. We show that feedback regularization is the mechanical system equivalent to partial feedback linearization. We apply these results for trajectory tracking for several systems of interest in the field of robotics. First, we demonstrate the robust almost-global stability properties of the geometric PID controller developed for fully actuated mechanical systems using simulations and experiments on a multi-rotor-aerial-vehicle. The extension to the class of under actuated interconnected systems allow one to ensure the semi-almost-global locally exponential tracking of the geometric center of a spherical robot on an inclined plane of unknown angle of inclination. The results are demonstrated using simulations for a hoop rolling on an inclined plane and then for a sphere rolling on an inclined plane. The final extension that we present here is that of geometric PID control for holonomically or non-holonomically constrained mechanical systems on Lie groups. The results are demonstrated by ensuring the robust almost global locally exponential tracking of a nontrivial spherical pendulum., Comment: Invited Talk, Systems & Control Engineering, IIT Bombay, 19-26 October 2016

Published
2016

11. Feedback Regularization and Geometric PID Control for Trajectory Tracking of Coupled Mechanical Systems: Hoop Robots on an Inclined Plane

Author

Madhushani, T. W. U., Maithripala, D. H. S., and Berg, J. M.

Subjects
Mathematics - Optimization and Control, 93D06
Abstract

This paper applies geometric PID control for asymptotic tracking of a desired trajectory by a hoop robot in the presence of disturbances and uncertainties. The hoop robot, consisting of a circular body rolling without slip along a one-dimensional surface, is a planar analog of a spherical robot. A variety of coupled mechanical system may be used to actuate the hoop robot. This paper specifically considers two different actuators, one a simple pendulum and the other an internal cart. The geometric PID controller requires the plant to be a mechanical system, and the hoop robot does not satisfy this condition. Therefore a geometric inner loop is presented that gives the hoop robot the required structure. This procedure is here referred to as feedback regularization. Feedback regularization--in contrast to feedback linearization--is coordinate independent, and hence reflects the fundamental system structure. Note also that the resulting mechanical system is nonlinear and underactuated. Subsequently, the geometric PID outer loop guarantees almost-semiglobal tracking with locally exponential convergence, and the integral action of the PID guarantees robustness to constant disturbances and parameter uncertainties, including constant inclination of the rolling surface. The complete tracking controller is the composition of the two coordinate-independent loops, and therefore is also coordinate independent., Comment: To be presented at the American Control Conference 2017, May 24--26, Seattle, WA, USA

Published
2016

12. Semi-globally Exponential Trajectory Tracking for a Class of Spherical Robots

Author

Madhushani, T. W. U., Maithripala, D. H. S., Wijayakulasooriya, J. V., and Berg, J. M.

Subjects
Mathematics - Optimization and Control
Abstract

A spherical robot consists of an externally spherical rigid body rolling on a two-dimensional surface, actuated by an auxiliary mechanism. For a class of actuation mechanisms, we derive a controller for the geometric center of the sphere to asymptotically track any sufficiently smooth reference trajectory, with robustness to bounded, constant uncertainties in the inertial properties of the sphere and actuation mechanism, and to constant disturbance forces including, for example, from constant inclination of the rolling surface. The sphere and actuator are modeled as distinct systems, coupled by reaction forces. It is assumed that the actuator can provide three independent control torques, and that the actuator center of mass remains at a constant distance from the geometric center of the sphere. We show that a necessary and sufficient condition for such a controller to exist is that for any constant disturbance torque acting on the sphere there is a constant input such that the sphere and the actuator mechanism has a stable relative equilibrium. A geometric PID controller guarantees robust, semi-global, locally exponential stability for the position tracking error of the geometric center of the sphere, while ensuring that actuator velocities are bounded., Comment: Pre-print submitted to Automatica on 01/03/2017

Published
2016
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13. The impact of patient-reported frailty on cardiovascular outcomes in elderly patients after non-ST-acute coronary syndrome

Author

van den Broek, W. W.A., Gimbel, M. E., Hermanides, R. S., Runnett, C., Storey, R. F., Knaapen, P., Emans, M. E., Oemrawsingh, R. M., Cooke, J., Galasko, G., Walhout, R., Stoel, M. G., von Birgelen, C., van Bergen, Paul F.M.M., Brinckman, S. L., Aksoy, I., Liem, A., van't Hof, A. W.J., Jukema, J. W., Heestermans, A. A.C.M., Nicastia, D., Alber, H., Austin, D., Nasser, A., Deneer, V., ten Berg, J. M., van den Broek, W. W.A., Gimbel, M. E., Hermanides, R. S., Runnett, C., Storey, R. F., Knaapen, P., Emans, M. E., Oemrawsingh, R. M., Cooke, J., Galasko, G., Walhout, R., Stoel, M. G., von Birgelen, C., van Bergen, Paul F.M.M., Brinckman, S. L., Aksoy, I., Liem, A., van't Hof, A. W.J., Jukema, J. W., Heestermans, A. A.C.M., Nicastia, D., Alber, H., Austin, D., Nasser, A., Deneer, V., and ten Berg, J. M.

Abstract

Background: As life expectancy increases, the population of older individuals with coronary artery disease and frailty is growing. We aimed to assess the impact of patient-reported frailty on the treatment and prognosis of elderly early survivors of non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods: Frailty data were obtained from two prospective trials, POPular Age and the POPular Age Registry, which both assessed elderly NSTE-ACS patients. Frailty was assessed one month after admission with the Groningen Frailty Indicator (GFI) and was defined as a GFI-score of 4 or higher. In these early survivors of NSTE-ACS, we assessed differences in treatment and 1-year outcomes between frail and non-frail patients, considering major adverse cardiovascular events (MACE, including cardiovascular mortality, myocardial infarction, and stroke) and major bleeding. Results: The total study population consisted of 2192 NSTE-ACS patients, aged ≥70 years. The GFI-score was available in 1320 patients (79 ± 5 years, 37% women), of whom 712 (54%) were considered frail. Frail patients were at higher risk for MACE than non-frail patients (9.7% vs. 5.1%, adjusted hazard ratio [HR] 1.57, 95% confidence interval [CI] 1.01–2.43, p = 0.04), but not for major bleeding (3.7% vs. 2.8%, adjusted HR 1.23, 95% CI 0.65–2.32, p = 0.53). Cubic spline analysis showed a gradual increase of the risk for clinical outcomes with higher GFI-scores. Conclusions: In elderly NSTE-ACS patients who survived 1-month follow-up, patient-reported frailty was independently associated with a higher risk for 1-year MACE, but not with major bleeding. These findings emphasize the importance of frailty screening for risk stratification in elderly NSTE-ACS patients.

Published
2024

14. The impact of patient-reported frailty on cardiovascular outcomes in elderly patients after non-ST-acute coronary syndrome

Author

Apotheek Klinische Farmacie, van den Broek, W. W.A., Gimbel, M. E., Hermanides, R. S., Runnett, C., Storey, R. F., Knaapen, P., Emans, M. E., Oemrawsingh, R. M., Cooke, J., Galasko, G., Walhout, R., Stoel, M. G., von Birgelen, C., van Bergen, Paul F.M.M., Brinckman, S. L., Aksoy, I., Liem, A., van't Hof, A. W.J., Jukema, J. W., Heestermans, A. A.C.M., Nicastia, D., Alber, H., Austin, D., Nasser, A., Deneer, V., ten Berg, J. M., Apotheek Klinische Farmacie, van den Broek, W. W.A., Gimbel, M. E., Hermanides, R. S., Runnett, C., Storey, R. F., Knaapen, P., Emans, M. E., Oemrawsingh, R. M., Cooke, J., Galasko, G., Walhout, R., Stoel, M. G., von Birgelen, C., van Bergen, Paul F.M.M., Brinckman, S. L., Aksoy, I., Liem, A., van't Hof, A. W.J., Jukema, J. W., Heestermans, A. A.C.M., Nicastia, D., Alber, H., Austin, D., Nasser, A., Deneer, V., and ten Berg, J. M.

Published
2024

15. The impact of patient-reported frailty on cardiovascular outcomes in elderly patients after non-ST-acute coronary syndrome

Author

Afd Pharmacoepi & Clinical Pharmacology, PECP – Centre for Clinical Therapeutics, Pharmacoepidemiology and Clinical Pharmacology, van den Broek, W. W.A., Gimbel, M. E., Hermanides, R. S., Runnett, C., Storey, R. F., Knaapen, P., Emans, M. E., Oemrawsingh, R. M., Cooke, J., Galasko, G., Walhout, R., Stoel, M. G., von Birgelen, C., van Bergen, Paul F.M.M., Brinckman, S. L., Aksoy, I., Liem, A., van't Hof, A. W.J., Jukema, J. W., Heestermans, A. A.C.M., Nicastia, D., Alber, H., Austin, D., Nasser, A., Deneer, V., ten Berg, J. M., Afd Pharmacoepi & Clinical Pharmacology, PECP – Centre for Clinical Therapeutics, Pharmacoepidemiology and Clinical Pharmacology, van den Broek, W. W.A., Gimbel, M. E., Hermanides, R. S., Runnett, C., Storey, R. F., Knaapen, P., Emans, M. E., Oemrawsingh, R. M., Cooke, J., Galasko, G., Walhout, R., Stoel, M. G., von Birgelen, C., van Bergen, Paul F.M.M., Brinckman, S. L., Aksoy, I., Liem, A., van't Hof, A. W.J., Jukema, J. W., Heestermans, A. A.C.M., Nicastia, D., Alber, H., Austin, D., Nasser, A., Deneer, V., and ten Berg, J. M.

Published
2024

17. Efficacy and Safety of Low Dose Rivaroxaban in High Ischemic Risk Patients with Chronic Coronary Syndrome: Rationale and Design of the Dutch CCS Registry

Author

Selvarajah, A., primary, Heijden, D. J. van der, additional, Remkes, W. S., additional, Berg, J. M. ten, additional, Magro, M., additional, von Birgelen, C., additional, Riezebos, R. K., additional, Pisters, R., additional, Hemels, M., additional, Rasoul, S., additional, Hof, A. W.J. van 't, additional, Somi, S., additional, Polad, J., additional, Hoogslag, P., additional, and Hermanides, R. S., additional

Published
2024
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29. Impact of patient-reported frailty on cardiovascular outcomes in elderly patients with non-ST-elevation myocardial infarction

Author

Van Den Broek, W W A, primary, Hermanides, R S, additional, Runnet, R, additional, Storey, R F, additional, Knaapen, P, additional, Emans, M E, additional, Oemrawsingh, R M, additional, Walhout, R, additional, Von Birgelen, C, additional, Liem, A, additional, Van 'T Hof, A W J, additional, Schellings, D A A M, additional, Jukema, J W, additional, Deneer, V, additional, and Ten Berg, J M, additional

Published
2023
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31. Competition and cooperation:aspects of dynamics in sandpiles

Author

Mehta, Anita, Luck, J M, Berg, J M, and Barker, G C

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Statistical Mechanics
Abstract

In this article, we review some of our approaches to granular dynamics, now well known to consist of both fast and slow relaxational processes. In the first case, grains typically compete with each other, while in the second, they cooperate. A typical result of {\it cooperation} is the formation of stable bridges, signatures of spatiotemporal inhomogeneities; we review their geometrical characteristics and compare theoretical results with those of independent simulations. {\it Cooperative} excitations due to local density fluctuations are also responsible for relaxation at the angle of repose; the {\it competition} between these fluctuations and external driving forces, can, on the other hand, result in a (rare) collapse of the sandpile to the horizontal. Both these features are present in a theory reviewed here. An arena where the effects of cooperation versus competition are felt most keenly is granular compaction; we review here a random graph model, where three-spin interactions are used to model compaction under tapping. The compaction curve shows distinct regions where 'fast' and 'slow' dynamics apply, separated by what we have called the {\it single-particle relaxation threshold}. In the final section of this paper, we explore the effect of shape -- jagged vs. regular -- on the compaction of packings near their jamming limit. One of our major results is an entropic landscape that, while microscopically rough, manifests {\it Edwards' flatness} at a macroscopic level. Another major result is that of surface intermittency under low-intensity shaking., Comment: 36 pages, 23 figures, minor corrections

Published
2004
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39. OP0162 PATTERNS OF CLINICAL JOINT INFLAMMATION IN JUVENILE IDIOPATHIC ARTHRITIS

Author

Heckert, S. L., primary, Hissink Muller, P. C. E., additional, Van den Berg, J. M., additional, Schonenberg-Meinema, D., additional, Van Suijlekom-Smit, L. W. A., additional, Van Rossum, M., additional, Koopman-Keemink, Y., additional, Ten Cate, R., additional, Brinkman, D. M. C., additional, Huizinga, T., additional, Allaart, C., additional, and Bergstra, S. A., additional

Published
2023
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40. OP0300 INCREASING THE ETANERCEPT DOSE IN JUVENILE IDIOPATHIC ARTHRITIS PATIENTS: DOES IT HELP REACHING THE TREATMENT TARGET? A POST-HOC ANALYSIS OF THE BEST4KIDS RANDOMISED CLINICAL TRIAL

Author

Van Dijk, B., primary, Bergstra, S. A., additional, Van den Berg, J. M., additional, Schonenberg-Meinema, D., additional, Van Suijlekom-Smit, L. W. A., additional, Van Rossum, M., additional, Koopman-Keemink, Y., additional, Ten Cate, R., additional, Allaart, C., additional, Brinkman, D. M. C., additional, and Hissink Muller, P. C. E., additional

Published
2023
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41. POS0134 LEARNING FROM LONGITUDINAL DATA IN CHILDHOOD ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: WHICH BIOMARKERS HAVE PREDICTIVE VALUE FOR ENDOTHELIAL INVOLVEMENT?

Author

Bergkamp, S., primary, Bergkamp, N., additional, Wahadat, M. J., additional, Gruppen, M., additional, Nassar-Sheikh Rashid, A., additional, Kuijpers, T., additional, Tas, S., additional, Smit, M., additional, Kamphuis, S., additional, Van den Berg, J. M., additional, and Schonenberg-Meinema, D., additional

Published
2023
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45. Relationship between molecular pathogen detection and clinical disease in febrile children across Europe:a multicentre, prospective observational study

Author

Shah, Priyen, Voice, Marie, Calvo-Bado, Leonides, Rivero-Calle, Irene, Morris, Sophie, Nijman, Ruud, Broderick, Claire, De, Tisham, Eleftheriou, Irini, Galassini, Rachel, Khanijau, Aakash, Kolberg, Laura, Kolnik, Mojca, Rudzate, Aleksandra, Sagmeister, Manfred, Schweintzger, Nina, Secka, Fatou, Thakker, Clare, van der Velden, Fabian, Vermont, Clementien, Vincek, Katarina, Agyeman, Philipp K.A., Cunnington, Aubrey J., De Groot, Ronald, Emonts, Marieke, Fidler, Katy, Kuijpers, Taco, Mommert-Tripon, Marine, Brengel-Pesce, Karen, Mallet, Francois, Moll, Henriette, Paulus, Stéphane, Pokorn, Marko, Pollard, Andrew, van der Flier, Michiel, Borensztajn, Dorine M., Hagedoorn, Nienke N., Zachariasse, Joany, Dik, W., Stocker, Martin, Willems, Esther, De Haan, L., Neeleman, C., Tramper-Stranders, G. A., Baas, Bryan, Kloosterhuis, Lieke, Oosthoek, Wilma, De Vries, Gabriella, van den Berg, J. M., Barendregt, A. M., Shah, Priyen, Voice, Marie, Calvo-Bado, Leonides, Rivero-Calle, Irene, Morris, Sophie, Nijman, Ruud, Broderick, Claire, De, Tisham, Eleftheriou, Irini, Galassini, Rachel, Khanijau, Aakash, Kolberg, Laura, Kolnik, Mojca, Rudzate, Aleksandra, Sagmeister, Manfred, Schweintzger, Nina, Secka, Fatou, Thakker, Clare, van der Velden, Fabian, Vermont, Clementien, Vincek, Katarina, Agyeman, Philipp K.A., Cunnington, Aubrey J., De Groot, Ronald, Emonts, Marieke, Fidler, Katy, Kuijpers, Taco, Mommert-Tripon, Marine, Brengel-Pesce, Karen, Mallet, Francois, Moll, Henriette, Paulus, Stéphane, Pokorn, Marko, Pollard, Andrew, van der Flier, Michiel, Borensztajn, Dorine M., Hagedoorn, Nienke N., Zachariasse, Joany, Dik, W., Stocker, Martin, Willems, Esther, De Haan, L., Neeleman, C., Tramper-Stranders, G. A., Baas, Bryan, Kloosterhuis, Lieke, Oosthoek, Wilma, De Vries, Gabriella, van den Berg, J. M., and Barendregt, A. M.

Abstract

Background: The PERFORM study aimed to understand causes of febrile childhood illness by comparing molecular pathogen detection with current clinical practice. Methods: Febrile children and controls were recruited on presentation to hospital in 9 European countries 2016–2020. Each child was assigned a standardized diagnostic category based on retrospective review of local clinical and microbiological data. Subsequently, centralised molecular tests (CMTs) for 19 respiratory and 27 blood pathogens were performed. Findings: Of 4611 febrile children, 643 (14%) were classified as definite bacterial infection (DB), 491 (11%) as definite viral infection (DV), and 3477 (75%) had uncertain aetiology. 1061 controls without infection were recruited. CMTs detected blood bacteria more frequently in DB than DV cases for N. meningitidis (OR: 3.37, 95% CI: 1.92–5.99), S. pneumoniae (OR: 3.89, 95% CI: 2.07–7.59), Group A streptococcus (OR 2.73, 95% CI 1.13–6.09) and E. coli (OR 2.7, 95% CI 1.02–6.71). Respiratory viruses were more common in febrile children than controls, but only influenza A (OR 0.24, 95% CI 0.11–0.46), influenza B (OR 0.12, 95% CI 0.02–0.37) and RSV (OR 0.16, 95% CI: 0.06–0.36) were less common in DB than DV cases. Of 16 blood viruses, enterovirus (OR 0.43, 95% CI 0.23–0.72) and EBV (OR 0.71, 95% CI 0.56–0.90) were detected less often in DB than DV cases. Combined local diagnostics and CMTs respectively detected blood viruses and respiratory viruses in 360 (56%) and 161 (25%) of DB cases, and virus detection ruled-out bacterial infection poorly, with predictive values of 0.64 and 0.68 respectively. Interpretation: Most febrile children cannot be conclusively defined as having bacterial or viral infection when molecular tests supplement conventional approaches. Viruses are detected in most patients with bacterial infections, and the clinical value of individual pathogen detection in determining treatment is low. New approaches are needed to help determine which

Published
2023

46. Dysregulated endothelial cell markers in systemic lupus erythematosus:a systematic review and meta-analysis

Author

Bergkamp, S. C., Wahadat, M. J., Salah, A., Kuijpers, T. W., Smith, V., Tas, S. W., van den Berg, J. M., Kamphuis, S., Schonenberg-Meinema, D., Bergkamp, S. C., Wahadat, M. J., Salah, A., Kuijpers, T. W., Smith, V., Tas, S. W., van den Berg, J. M., Kamphuis, S., and Schonenberg-Meinema, D.

Abstract

Objectives: To perform a systematic literature review and meta-analysis on endothelial cell (EC) markers that are involved and dysregulated in systemic lupus erythematosus (SLE) in relation to disease activity, as EC dysregulation plays a major role in the development of premature atherosclerosis in SLE. Methods: Search terms were entered into Embase, MEDLINE, Web of Science, Google Scholar and Cochrane. Inclusion criteria were 1) studies published after 2000 reporting measurements of EC markers in serum and/or plasma of SLE patients (diagnosed according to ACR/SLICC criteria), 2) English language peer reviewed articles, and 3) disease activity measurement. For meta-analysis calculations, the Meta-Essentials tool by Erasmus Research Institute and of Management (ERIM) was used. Only those EC markers, which were 1) reported in at least two articles and 2) reported a correlation coefficient (i.e. Spearman’s rank or Pearson’s) between the measured levels of the EC marker and disease activity were included. For meta-analyses, a fixed effect model was used. Results: From 2133 hits, 123 eligible articles were selected. The identified SLE-related endothelial markers were involved in EC activation, EC apoptosis, disturbed angiogenesis, defective vascular tone control, immune dysregulation and coagulopathy. Meta-analyses of primarily cross-sectional studies showed significant associations between marker levels and disease activity for the following endothelial markers: Pentraxin-3, Thrombomodulin, VEGF, VCAM-1, ICAM-1, IP-10 and MCP-1. Dysregulated EC markers without associations with disease activity were: Angiopoeitin-2, vWF, P-Selectin, TWEAK and E-Selectin. Conclusions: We provide a complete literature overview for dysregulated EC markers in SLE comprising a wide range of different EC functions. SLE-induced EC marker dysregulation was seen with, but also without, association with disease activity. This study provides some clarity in the eminent complex field of EC mark

Published
2023

47. Genomic investigations of unexplained acute hepatitis in children

Author

Morfopoulou, Sofia, Buddle, Sarah, Torres Montaguth, Oscar Enrique, Atkinson, Laura, Guerra-Assunção, José Afonso, Moradi Marjaneh, Mahdi, Zennezini Chiozzi, Riccardo, Storey, Nathaniel, Campos, Luis, Hutchinson, J. Ciaran, Counsell, John R., Pollara, Gabriele, Roy, Sunando, Venturini, Cristina, Antinao Diaz, Juan F., Siam, Ala’a, Tappouni, Luke J., Asgarian, Zeinab, Ng, Joanne, Hanlon, Killian S., Lennon, Alexander, McArdle, Andrew, Nijman, Ruud, Peters, Mark, Emonts, Marieke, van der Zee, Carlijn, Vermont, Clementien L., Moll, Henriëtte A., Borensztajn, Dorine M., Hagedoorn, Nienke N., Tan, Chantal, Zachariasse, Joany, Dik, W., van der Flier, Michiel, Stocker, Martin, Tempel, Dennie, Hoffmann, Florian, de Groot, Ronald, Willems, Esther, de Haan, L., Neeleman, C., Tramper-Stranders, G. A., Baas, Bryan, Kloosterhuis, Lieke, Oosthoek, Wilma, de Vries, Gabriella, van den Berg, J. M., Barendregt, A. M., Breuer, Judith, Morfopoulou, Sofia, Buddle, Sarah, Torres Montaguth, Oscar Enrique, Atkinson, Laura, Guerra-Assunção, José Afonso, Moradi Marjaneh, Mahdi, Zennezini Chiozzi, Riccardo, Storey, Nathaniel, Campos, Luis, Hutchinson, J. Ciaran, Counsell, John R., Pollara, Gabriele, Roy, Sunando, Venturini, Cristina, Antinao Diaz, Juan F., Siam, Ala’a, Tappouni, Luke J., Asgarian, Zeinab, Ng, Joanne, Hanlon, Killian S., Lennon, Alexander, McArdle, Andrew, Nijman, Ruud, Peters, Mark, Emonts, Marieke, van der Zee, Carlijn, Vermont, Clementien L., Moll, Henriëtte A., Borensztajn, Dorine M., Hagedoorn, Nienke N., Tan, Chantal, Zachariasse, Joany, Dik, W., van der Flier, Michiel, Stocker, Martin, Tempel, Dennie, Hoffmann, Florian, de Groot, Ronald, Willems, Esther, de Haan, L., Neeleman, C., Tramper-Stranders, G. A., Baas, Bryan, Kloosterhuis, Lieke, Oosthoek, Wilma, de Vries, Gabriella, van den Berg, J. M., Barendregt, A. M., and Breuer, Judith

Abstract

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children.

Published
2023

49. Additional file 2 of Dysregulated endothelial cell markers in systemic lupus erythematosus: a systematic review and meta-analysis

Author

Bergkamp, S. C., Wahadat, M. J., Salah, A., Kuijpers, T. W., Smith, V., Tas, S. W., van den Berg, J. M., Kamphuis, S., and Schonenberg-Meinema, D.

Abstract

Additional file 2. Supplementary File 2 provides an overview of all included studies in chronological order and their characteristicscorrelation with disease activity, method of blood sample analysis. Figure A. Overview of the number of articles per EC marker reporting whether or not a significant correlation between plasma/serum levels of each EC marker and validated SLE disease activity index.

Published
2023
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