Search

Supplemental material, sj-pdf-2-msj-10.1177_13524585221097296 for Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis by Synne Brune, Einar A Høgestøl, Sigrid A de Rodez Benavent, Pål Berg-Hansen, Mona K Beyer, Ingvild Sørum Leikfoss, Steffan D Bos, Piotr Sowa, Cathrine Brunborg, Magi Andorra, Irene Pulido Valdeolivas, Susanna Asseyer, Alexander Brandt, Claudia Chien, Michael Scheel, Kaj Blennow, Henrik Zetterberg, Nicole Kerlero de Rosbo, Friedemann Paul, Antonio Uccelli, Pablo Villoslada, Tone Berge and Hanne F Harbo in Multiple Sclerosis Journal

Supplemental material, sj-docx-13-msj-10.1177_13524585221097296 for Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis by Synne Brune, Einar A Høgestøl, Sigrid A de Rodez Benavent, Pål Berg-Hansen, Mona K Beyer, Ingvild Sørum Leikfoss, Steffan D Bos, Piotr Sowa, Cathrine Brunborg, Magi Andorra, Irene Pulido Valdeolivas, Susanna Asseyer, Alexander Brandt, Claudia Chien, Michael Scheel, Kaj Blennow, Henrik Zetterberg, Nicole Kerlero de Rosbo, Friedemann Paul, Antonio Uccelli, Pablo Villoslada, Tone Berge and Hanne F Harbo in Multiple Sclerosis Journal

Supplemental material, sj-docx-9-msj-10.1177_13524585221097296 for Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis by Synne Brune, Einar A Høgestøl, Sigrid A de Rodez Benavent, Pål Berg-Hansen, Mona K Beyer, Ingvild Sørum Leikfoss, Steffan D Bos, Piotr Sowa, Cathrine Brunborg, Magi Andorra, Irene Pulido Valdeolivas, Susanna Asseyer, Alexander Brandt, Claudia Chien, Michael Scheel, Kaj Blennow, Henrik Zetterberg, Nicole Kerlero de Rosbo, Friedemann Paul, Antonio Uccelli, Pablo Villoslada, Tone Berge and Hanne F Harbo in Multiple Sclerosis Journal

Supplemental material, sj-docx-8-msj-10.1177_13524585221097296 for Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis by Synne Brune, Einar A Høgestøl, Sigrid A de Rodez Benavent, Pål Berg-Hansen, Mona K Beyer, Ingvild Sørum Leikfoss, Steffan D Bos, Piotr Sowa, Cathrine Brunborg, Magi Andorra, Irene Pulido Valdeolivas, Susanna Asseyer, Alexander Brandt, Claudia Chien, Michael Scheel, Kaj Blennow, Henrik Zetterberg, Nicole Kerlero de Rosbo, Friedemann Paul, Antonio Uccelli, Pablo Villoslada, Tone Berge and Hanne F Harbo in Multiple Sclerosis Journal

Supplemental material, sj-pdf-3-msj-10.1177_13524585221097296 for Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis by Synne Brune, Einar A Høgestøl, Sigrid A de Rodez Benavent, Pål Berg-Hansen, Mona K Beyer, Ingvild Sørum Leikfoss, Steffan D Bos, Piotr Sowa, Cathrine Brunborg, Magi Andorra, Irene Pulido Valdeolivas, Susanna Asseyer, Alexander Brandt, Claudia Chien, Michael Scheel, Kaj Blennow, Henrik Zetterberg, Nicole Kerlero de Rosbo, Friedemann Paul, Antonio Uccelli, Pablo Villoslada, Tone Berge and Hanne F Harbo in Multiple Sclerosis Journal

Supplemental material, sj-pdf-1-msj-10.1177_13524585221097296 for Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis by Synne Brune, Einar A Høgestøl, Sigrid A de Rodez Benavent, Pål Berg-Hansen, Mona K Beyer, Ingvild Sørum Leikfoss, Steffan D Bos, Piotr Sowa, Cathrine Brunborg, Magi Andorra, Irene Pulido Valdeolivas, Susanna Asseyer, Alexander Brandt, Claudia Chien, Michael Scheel, Kaj Blennow, Henrik Zetterberg, Nicole Kerlero de Rosbo, Friedemann Paul, Antonio Uccelli, Pablo Villoslada, Tone Berge and Hanne F Harbo in Multiple Sclerosis Journal

Supplemental material, sj-pdf-4-msj-10.1177_13524585221097296 for Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis by Synne Brune, Einar A Høgestøl, Sigrid A de Rodez Benavent, Pål Berg-Hansen, Mona K Beyer, Ingvild Sørum Leikfoss, Steffan D Bos, Piotr Sowa, Cathrine Brunborg, Magi Andorra, Irene Pulido Valdeolivas, Susanna Asseyer, Alexander Brandt, Claudia Chien, Michael Scheel, Kaj Blennow, Henrik Zetterberg, Nicole Kerlero de Rosbo, Friedemann Paul, Antonio Uccelli, Pablo Villoslada, Tone Berge and Hanne F Harbo in Multiple Sclerosis Journal

Supplemental material, sj-pdf-4-mso-10.1177_2055217321999826 for High prevalence of fatigue in contemporary patients with multiple sclerosis by Line Broch, Cecilia Smith Simonsen, Heidi Øyen Flemmen, Pål Berg-Hansen, Åshild Skardhamar, Heidi Ormstad and Elisabeth Gulowsen Celius in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Supplemental material, Supplemental Material6 for No differential gene expression for CD4+ T cells of MS patients and healthy controls by Ina S Brorson, Anna Eriksson, Ingvild S Leikfoss, Elisabeth G Celius, Pål Berg-Hansen, Lisa F Barcellos, Tone Berge, Hanne F Harbo and Steffan D Bos in Multiple Sclerosis Journal – Experimental, Translational and Clinical

Background Multiple sclerosis-associated genetic variants indicate that the adaptive immune system plays an important role in the risk of developing multiple sclerosis. It is currently not well understood how these multiple sclerosis-associated genetic variants contribute to multiple sclerosis risk. CD4+ T cells are suggested to be involved in multiple sclerosis disease processes. Objective We aim to identify CD4+ T cell differential gene expression between multiple sclerosis patients and healthy controls in order to understand better the role of these cells in multiple sclerosis. Methods We applied RNA sequencing on CD4+ T cells from multiple sclerosis patients and healthy controls. Results We did not identify significantly differentially expressed genes in CD4+ T cells from multiple sclerosis patients. Furthermore, pathway analyses did not identify enrichment for specific pathways in multiple sclerosis. When we investigated genes near multiple sclerosis-associated genetic variants, we did not observe significant enrichment of differentially expressed genes. Conclusion We conclude that CD4+ T cells from multiple sclerosis patients do not show significant differential gene expression. Therefore, gene expression studies of all circulating CD4+ T cells may not result in viable biomarkers. Gene expression studies of more specific subsets of CD4+ T cells remain justified to understand better which CD4+ T cell subsets contribute to multiple sclerosis pathology.

Supplemental material, MSJ765671_supplementary_material_4 for Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis by Piotr Sowa, Hanne F Harbo, Nathan S White, Elisabeth G Celius, Hauke Bartsch, Pål Berg-Hansen, Stine M Moen, Atle Bjørnerud, Lars T Westlye, Ole A Andreassen, Anders M Dale and Mona K Beyer in Multiple Sclerosis Journal

Background: Several environmental exposures, including infection with Epstein-Barr virus, low levels of vitamin D and smoking are established risk factors for multiple sclerosis (MS). Also, high hygienic standard and infection with parasites have been proposed to influence MS risk. The aim of this study was to investigate the influence of various environmental exposures on MS risk in a Norwegian cohort, focusing on factors during childhood related to the hygiene hypothesis. Methods: A questionnaire concerning environmental exposures, lifestyle, demographics and comorbidity was administrated to 756 Norwegian MS patients and 1090 healthy controls. Logistic regression was used to calculate odds ratio (OR) with 95% confidence interval (CI) for the risk of MS associated with the variables infectious mononucleosis, severe infection during childhood, vaccination and animals in the household during childhood. Age, gender, HLA-DRB1*15:01, smoking and infectious mononucleosis were included as covariates. General environmental exposures, including tobacco use, were also evaluated. Results: Infectious mononucleosis was confirmed to be significantly associated with increased MS risk, also after adjusting for the covariates (OR?=?1.79, 95% CI: 1.12-2.87, p?=?0.016). The controls more often reported growing up with a cat and/or a dog in the household, and this was significant for ownership of cat also after adjusting for the covariates (OR?=?0.56, 95% CI: 0.40-0.78, p?=?0.001). More patients than controls reported smoking and fewer patients reported snuff use. Conclusions: In this Norwegian MS case-control study of environmental exposures, we replicate that infectious mononucleosis and smoking are associated with increased MS risk. Our data also indicate a protective effect on MS of exposure to cats during childhood, in accordance with the hypothesis that risk of autoimmune diseases like MS may increase with high hygienic standard.