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2. Lung adenocarcinoma promotion by air pollutants

Author

Hill, William, Lim, Emilia L., Weeden, Clare E., Lee, Claudia, Augustine, Marcellus, Chen, Kezhong, Kuan, Feng-Che, Marongiu, Fabio, Evans, Jr, Edward J., Moore, David A., Rodrigues, Felipe S., Pich, Oriol, Bakker, Bjorn, Cha, Hongui, Myers, Renelle, van Maldegem, Febe, Boumelha, Jesse, Veeriah, Selvaraju, Rowan, Andrew, Naceur-Lombardelli, Cristina, Karasaki, Takahiro, Sivakumar, Monica, De, Swapnanil, Caswell, Deborah R., Nagano, Ai, Black, James R. M., Martínez-Ruiz, Carlos, Ryu, Min Hyung, Huff, Ryan D., Li, Shijia, Favé, Marie-Julie, Magness, Alastair, Suárez-Bonnet, Alejandro, Priestnall, Simon L., Lüchtenborg, Margreet, Lavelle, Katrina, Pethick, Joanna, Hardy, Steven, McRonald, Fiona E., Lin, Meng-Hung, Troccoli, Clara I., Ghosh, Moumita, Miller, York E., Merrick, Daniel T., Keith, Robert L., Al Bakir, Maise, Bailey, Chris, Hill, Mark S., Saal, Lao H., Chen, Yilun, George, Anthony M., Abbosh, Christopher, Kanu, Nnennaya, Lee, Se-Hoon, McGranahan, Nicholas, Berg, Christine D., Sasieni, Peter, Houlston, Richard, Turnbull, Clare, Lam, Stephen, Awadalla, Philip, Grönroos, Eva, Downward, Julian, Jacks, Tyler, Carlsten, Christopher, Malanchi, Ilaria, Hackshaw, Allan, Litchfield, Kevin, DeGregori, James, Jamal-Hanjani, Mariam, and Swanton, Charles

Published
2023
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4. Statistical approaches using longitudinal biomarkers for disease early detection: A comparison of methodologies

Author

Han, Yongli, Albert, Paul S., Berg, Christine D., Wentzensen, Nicolas, Katki, Hormuzd A., and Liu, Danping

Subjects
Statistics - Applications, Statistics - Methodology
Abstract

Early detection of clinical outcomes such as cancer may be predicted based on longitudinal biomarker measurements. Tracking longitudinal biomarkers as a way to identify early disease onset may help to reduce mortality from diseases like ovarian cancer that are more treatable if detected early. Two general frameworks for disease risk prediction, the shared random effects model (SREM) and the pattern mixture model (PMM) could be used to assess longitudinal biomarkers on disease early detection. In this paper, we studied the predictive performances of SREM and PMM on disease early detection through an application to ovarian cancer, where early detection using the risk of ovarian cancer algorithm (ROCA) has been evaluated. Comparisons of the above three methods were performed via the analyses of the ovarian cancer data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and extensive simulation studies. The time-dependent receiving operating characteristic (ROC) curve and its area (AUC) were used to evaluate the prediction accuracy. The out-of-sample predictive performance was calculated using leave-one-out cross-validation (LOOCV), aiming to minimize the problem of model over-fitting. A careful analysis of the use of the biomarker cancer antigen 125 for ovarian cancer early detection showed improved performance of PMM as compared with SREM and ROCA. More generally, simulation studies showed that PMM outperforms ROCA unless biomarkers are taken at very frequent screening settings.

Published
2019

5. Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Author

Robbins, Hilary A., Alcala, Karine, Moez, Elham Khodayari, Guida, Florence, Thomas, Sera, Zahed, Hana, Warkentin, Matthew T., Smith-Byrne, Karl, Brhane, Yonathan, Muller, David, Feng, Xiaoshuang, Albanes, Demetrius, Aldrich, Melinda C., Arslan, Alan A., Bassett, Julie, Berg, Christine D., Cai, Qiuyin, Chen, Chu, Davies, Michael P.A., Diergaarde, Brenda, Field, John K., Freedman, Neal D., Huang, Wen-Yi, Johansson, Mikael, Jones, Michael, Koh, Woon-Puay, Lam, Stephen, Lan, Qing, Langhammer, Arnulf, Liao, Linda M., Liu, Geoffrey, Malekzadeh, Reza, Milne, Roger L., Montuenga, Luis M., Rohan, Thomas, Sesso, Howard D., Severi, Gianluca, Sheikh, Mahdi, Sinha, Rashmi, Shu, Xiao-Ou, Stevens, Victoria L., Tammemägi, Martin C., Tinker, Lesley F., Visvanathan, Kala, Wang, Ying, Wang, Renwei, Weinstein, Stephanie J., White, Emily, Wilson, David, Yuan, Jian-Min, Zhang, Xuehong, Zheng, Wei, Amos, Christopher I., Brennan, Paul, Johansson, Mattias, and Hung, Rayjean J.

Published
2023
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6. Evaluation of a novel extracellular vesicle (EV) based ovarian cancer (OC) screening test in asymptomatic postmenopausal women.

Author

Manning, Brendan, primary, Banerjee, Sanchari, additional, Bortolin, Laura T, additional, Winn-Deen, Emily S., additional, Hamzeh, Bilal, additional, Grimes, Brittany, additional, Santos-Heiman, Timothy, additional, Byrne, Delaney M., additional, Hawkins, Troy B, additional, King, MacKenzie Sadie, additional, Salem, Daniel P., additional, Smith, Michael, additional, Apostolidou, Sophia, additional, Gentry-Maharaj, Aleksandra, additional, Berg, Christine D., additional, Skates, Steven, additional, Ransohoff, David, additional, Guettouche, Toumy, additional, Mattoon, Dawn R, additional, and Menon, Usha, additional

Published
2024
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9. USPSTF2013 versus PLCOm2012 lung cancer screening eligibility criteria (International Lung Screening Trial): interim analysis of a prospective cohort study

Author

Tammemägi, Martin C, Ruparel, Mamta, Tremblay, Alain, Myers, Renelle, Mayo, John, Yee, John, Atkar-Khattra, Sukhinder, Yuan, Ren, Cressman, Sonya, English, John, Bedard, Eric, MacEachern, Paul, Burrowes, Paul, Quaife, Samantha L, Marshall, Henry, Yang, Ian, Bowman, Rayleen, Passmore, Linda, McWilliams, Annette, Brims, Fraser, Lim, Kuan Pin, Mo, Lin, Melsom, Stephen, Saffar, Bann, Teh, Mark, Sheehan, Ramon, Kuok, Yijin, Manser, Renee, Irving, Louis, Steinfort, Daniel, McCusker, Mark, Pascoe, Diane, Fogarty, Paul, Stone, Emily, Lam, David C L, Ng, Ming-Yen, Vardhanabhuti, Varut, Berg, Christine D, Hung, Rayjean J, Janes, Samuel M, Fong, Kwun, and Lam, Stephen

Published
2022
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10. Abstract A040: Improving specificity for ovarian cancer screening using a novel extracellular vesicle-based blood test

Author

Winn-Deen, Emily S., primary, Banerjee, Sanchari, additional, Gusenleitner, Daniel, additional, Bortolin, Laura T., additional, Grosha, Jonian, additional, Biette, Kelly M., additional, Copeland, Karen, additional, Sedlak, Christopher R., additional, Hamzeh, Bilal, additional, Couvillon, Anthony D., additional, Byrne, Delaney M., additional, Duff, Peter A., additional, Cuoco, Lauren T., additional, King, MacKenzie S., additional, Gentry-Maharaj, Aleksandra, additional, Apostolidou, Sophia, additional, Mattoon, Dawn R., additional, Berg, Christine D., additional, Ransohoff, David F., additional, Skates, Steven J., additional, and Menon, Usha, additional

Published
2024
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11. Identifying post-menopausal women at elevated risk for epithelial ovarian cancer

Author

Urban, Nicole, Hawley, Sarah, Janes, Holly, Karlan, Beth Y, Berg, Christine D, Drescher, Charles W, Manson, JoAnn E, Palomares, Melanie R, Daly, Mary B, Wactawski-Wende, Jean, O'Sullivan, Mary J, Thorpe, Jason, Robinson, Randal D, Lane, Dorothy, Li, Christopher I, and Anderson, Garnet L

Subjects
Rare Diseases, Clinical Research, Aging, Ovarian Cancer, Prevention, Breast Cancer, Estrogen, Cancer, Aged, Aged, 80 and over, Biomarkers, Tumor, Breast Feeding, Breast Neoplasms, CA-125 Antigen, Carcinoma, Ovarian Epithelial, Case-Control Studies, Contraceptives, Oral, Hormonal, Estrogen Replacement Therapy, Female, Humans, Middle Aged, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Parity, Postmenopause, Proportional Hazards Models, Proteins, Risk Assessment, Risk Factors, Sterilization, Tubal, Talc, WAP Four-Disulfide Core Domain Protein 2, Ovarian cancer, Risk prediction, CA125, HE4, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis
Abstract

ObjectiveWe developed and validated a hybrid risk classifier combining serum markers and epidemiologic risk factors to identify post-menopausal women at elevated risk for invasive fallopian tube, primary peritoneal, and ovarian epithelial carcinoma.MethodsTo select epidemiologic risk factors for use in the classifier, Cox proportional hazards analyses were conducted using 74,786 Women's Health Initiative (WHI) Observational Study (OS) participants. To construct a combination classifier, 210 WHI OS cases and 536 matched controls with serum marker measurements were analyzed; validation employed 143 cases and 725 matched controls from the WHI Clinical Trial (CT) with similar data.ResultsAnalyses identified a combination risk classifier composed of two elevated-risk groups: 1) women with CA125 or HE4 exceeding a 98% specificity threshold; and 2) women with intact fallopian tubes, prior use of menopausal hormone therapy for at least two years, and either a first degree relative with breast or ovarian cancer or a personal history of breast cancer. In the WHI OS population, it classified 13% of women as elevated risk, identifying 30% of ovarian cancers diagnosed up to 7.8years post-enrollment (Hazard Ratio [HR]=2.6, p

Published
2015

12. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming, Zhu, Bin, Zhang, Mingfeng, Parikh, Hemang, Jia, Jinping, Chung, Charles C, Sampson, Joshua N, Hoskins, Jason W, Hutchinson, Amy, Burdette, Laurie, Ibrahim, Abdisamad, Hautman, Christopher, Raj, Preethi S, Abnet, Christian C, Adjei, Andrew A, Ahlbom, Anders, Albanes, Demetrius, Allen, Naomi E, Ambrosone, Christine B, Aldrich, Melinda, Amiano, Pilar, Amos, Christopher, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Arici, Cecilia, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Beane Freeman, Laura E, Berg, Christine D, Berndt, Sonja I, Bertazzi, Pier Alberto, Biritwum, Richard B, Black, Amanda, Blot, William, Boeing, Heiner, Boffetta, Paolo, Bolton, Kelly, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brennan, Paul, Brinton, Louise A, Brotzman, Michelle, Bueno-de-Mesquita, H Bas, Buring, Julie E, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Cao, Guangwen, Caporaso, Neil E, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chang, Gee-Chen, Chang, I-Shou, Chang-Claude, Jenny, Che, Xu, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chung-Hsing, Chen, Constance, Chen, Kuan-Yu, Chen, Yuh-Min, Chokkalingam, Anand P, Chu, Lisa W, Clavel-Chapelon, Francoise, Colditz, Graham A, Colt, Joanne S, Conti, David, Cook, Michael B, Cortessis, Victoria K, Crawford, E David, Cussenot, Olivier, Davis, Faith G, De Vivo, Immaculata, Deng, Xiang, Ding, Ti, Dinney, Colin P, Di Stefano, Anna Luisa, Diver, W Ryan, Duell, Eric J, Elena, Joanne W, Fan, Jin-Hu, Feigelson, Heather Spencer, Feychting, Maria, Figueroa, Jonine D, Flanagan, Adrienne M, Fraumeni, Joseph F, Freedman, Neal D, Fridley, Brooke L, Fuchs, Charles S, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, and Garcia-Closas, Montserrat

Subjects
Biological Sciences, Genetics, Cancer, Clinical Research, Human Genome, Prevention, Aetiology, 2.1 Biological and endogenous factors, Alleles, Chromosomes, Human, Pair 5, Computational Biology, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Membrane Proteins, Neoplasm Proteins, Neoplasms, Odds Ratio, Polymorphism, Single Nucleotide, Risk, Telomerase, Medical and Health Sciences, Genetics & Heredity
Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Published
2014

13. A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11

Author

Siddiq, Afshan, Couch, Fergus J, Chen, Gary K, Lindström, Sara, Eccles, Diana, Millikan, Robert C, Michailidou, Kyriaki, Stram, Daniel O, Beckmann, Lars, Rhie, Suhn Kyong, Ambrosone, Christine B, Aittomäki, Kristiina, Amiano, Pilar, Apicella, Carmel, Investigators, Australian Breast Cancer Tissue Bank, Baglietto, Laura, Bandera, Elisa V, Beckmann, Matthias W, Berg, Christine D, Bernstein, Leslie, Blomqvist, Carl, Brauch, Hiltrud, Brinton, Louise, Bui, Quang M, Buring, Julie E, Buys, Saundra S, Campa, Daniele, Carpenter, Jane E, Chasman, Daniel I, Chang-Claude, Jenny, Chen, Constance, Clavel-Chapelon, Françoise, Cox, Angela, Cross, Simon S, Czene, Kamila, Deming, Sandra L, Diasio, Robert B, Diver, W Ryan, Dunning, Alison M, Durcan, Lorraine, Ekici, Arif B, Fasching, Peter A, Study, Familial Breast Cancer, Feigelson, Heather Spencer, Fejerman, Laura, Figueroa, Jonine D, Fletcher, Olivia, Flesch-Janys, Dieter, Gaudet, Mia M, Consortium, The GENICA, Gerty, Susan M, Rodriguez-Gil, Jorge L, Giles, Graham G, van Gils, Carla H, Godwin, Andrew K, Graham, Nikki, Greco, Dario, Hall, Per, Hankinson, Susan E, Hartmann, Arndt, Hein, Rebecca, Heinz, Judith, Hoover, Robert N, Hopper, John L, Hu, Jennifer J, Huntsman, Scott, Ingles, Sue A, Irwanto, Astrid, Isaacs, Claudine, Jacobs, Kevin B, John, Esther M, Justenhoven, Christina, Kaaks, Rudolf, Kolonel, Laurence N, Coetzee, Gerhard A, Lathrop, Mark, Le Marchand, Loic, Lee, Adam M, Lee, I-Min, Lesnick, Timothy, Lichtner, Peter, Liu, Jianjun, Lund, Eiliv, Makalic, Enes, Martin, Nicholas G, McLean, Catriona A, Meijers-Heijboer, Hanne, Meindl, Alfons, Miron, Penelope, Monroe, Kristine R, Montgomery, Grant W, Müller-Myhsok, Bertram, Nickels, Stefan, Nyante, Sarah J, Olswold, Curtis, Overvad, Kim, Palli, Domenico, Park, Daniel J, Palmer, Julie R, and Pathak, Harsh

Subjects
Biological Sciences, Genetics, Clinical Research, Aging, Human Genome, Breast Cancer, Cancer, Aetiology, 2.1 Biological and endogenous factors, Breast Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Receptors, Estrogen, Australian Breast Cancer Tissue Bank Investigators, Familial Breast Cancer Study, GENICA Consortium, Medical and Health Sciences, Genetics & Heredity
Abstract

Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS: NCI Breast and Prostate Cancer Cohort Consortium (BPC3) (2188 ER-negative cases; 25 519 controls of European ancestry), Triple Negative Breast Cancer Consortium (TNBCC) (1562 triple negative cases; 3399 controls of European ancestry) and African American Breast Cancer Consortium (AABC) (1004 ER-negative cases; 2745 controls). We performed in silico replication of 86 SNPs at P ≤ 1 × 10(-5) in an additional 11 209 breast cancer cases (946 with ER-negative disease) and 16 057 controls of Japanese, Latino and European ancestry. We identified two novel loci for breast cancer at 20q11 and 6q14. SNP rs2284378 at 20q11 was associated with ER-negative breast cancer (combined two-stage OR = 1.16; P = 1.1 × 10(-8)) but showed a weaker association with overall breast cancer (OR = 1.08, P = 1.3 × 10(-6)) based on 17 869 cases and 43 745 controls and no association with ER-positive disease (OR = 1.01, P = 0.67) based on 9965 cases and 22 902 controls. Similarly, rs17530068 at 6q14 was associated with breast cancer (OR = 1.12; P = 1.1 × 10(-9)), and with both ER-positive (OR = 1.09; P = 1.5 × 10(-5)) and ER-negative (OR = 1.16, P = 2.5 × 10(-7)) disease. We also confirmed three known loci associated with ER-negative (19p13) and both ER-negative and ER-positive breast cancer (6q25 and 12p11). Our results highlight the value of large-scale collaborative studies to identify novel breast cancer risk loci.

Published
2012

14. Cancer Screening: The Journey from Epidemiology to Policy

Author

Deppen, Stephen A, Aldrich, Melinda C, Hartge, Patricia, Berg, Christine D, Colditz, Graham A, Petitti, Diana B, and Hiatt, Robert A

Subjects
Health Services and Systems, Public Health, Health Sciences, Breast Cancer, Clinical Research, Cancer, Lung Cancer, Prevention, Lung, Health Services, Breast Neoplasms, Early Detection of Cancer, Epidemiology, Health Policy, Humans, Interprofessional Relations, Lung Neoplasms, Policy Making, Politics, Professional Role, Public Opinion, United States, Cancer Screening, Public Policy, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

PurposeCancer screening procedures have brought great benefit to the public's health. However, the science of cancer screening and the evidence arising from research in this field as it is applied to policy is complex and has been difficult to communicate, especially on the national stage. We explore how epidemiologists have contributed to this evidence base and to its translation into policy.MethodsOur essay focuses on breast and lung cancer screening to identify commonalities of experience by epidemiologists across two different cancer sites and describe how epidemiologists interact with evolving scientific and policy environments.ResultsWe describe the roles and challenges that epidemiologists encounter according to the maturity of the data, stakeholders, and the related political context. We also explore the unique position of cancer screening as influenced by the legislative landscape where, due to recent healthcare reform, cancer screening research plays directly into national policy.ConclusionsIn the complex landscape for cancer screening policy, epidemiologists can increase their impact by learning from past experiences, being well prepared and communicating effectively.

Published
2012

16. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

Author

Petersen, Gloria M, Amundadottir, Laufey, Fuchs, Charles S, Kraft, Peter, Stolzenberg-Solomon, Rachael Z, Jacobs, Kevin B, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gallinger, Steven, Gross, Myron, Helzlsouer, Kathy, Holly, Elizabeth A, Jacobs, Eric J, Klein, Alison P, LaCroix, Andrea, Li, Donghui, Mandelson, Margaret T, Olson, Sara H, Risch, Harvey A, Zheng, Wei, Albanes, Demetrius, Bamlet, William R, Berg, Christine D, Boutron-Ruault, Marie-Christine, Buring, Julie E, Bracci, Paige M, Canzian, Federico, Clipp, Sandra, Cotterchio, Michelle, de Andrade, Mariza, Duell, Eric J, Gaziano, J Michael, Giovannucci, Edward L, Goggins, Michael, Hallmans, Göran, Hankinson, Susan E, Hassan, Manal, Howard, Barbara, Hunter, David J, Hutchinson, Amy, Jenab, Mazda, Kaaks, Rudolf, Kooperberg, Charles, Krogh, Vittorio, Kurtz, Robert C, Lynch, Shannon M, McWilliams, Robert R, Mendelsohn, Julie B, Michaud, Dominique S, Parikh, Hemang, Patel, Alpa V, Peeters, Petra HM, Rajkovic, Aleksandar, Riboli, Elio, Rodriguez, Laudina, Seminara, Daniela, Shu, Xiao-Ou, Thomas, Gilles, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Van Den Eeden, Stephen K, Virtamo, Jarmo, Wactawski-Wende, Jean, Wang, Zhaoming, Wolpin, Brian M, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Fraumeni, Joseph F, Hoover, Robert N, Hartge, Patricia, and Chanock, Stephen J

Subjects
Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 13, Humans, Carcinoma, Pancreatic Neoplasms, Genetic Predisposition to Disease, Case-Control Studies, Cohort Studies, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci, Rare Diseases, Cancer, Genetics, Clinical Research, Pancreatic Cancer, Digestive Diseases, Human Genome, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

Published
2010

17. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

Author

Amundadottir, Laufey, Kraft, Peter, Stolzenberg-Solomon, Rachael Z, Fuchs, Charles S, Petersen, Gloria M, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Zheng, Wei, Albanes, Demetrius, Bamlet, William, Berg, Christine D, Berrino, Franco, Bingham, Sheila, Buring, Julie E, Bracci, Paige M, Canzian, Federico, Clavel-Chapelon, Françoise, Clipp, Sandra, Cotterchio, Michelle, de Andrade, Mariza, Duell, Eric J, Fox, John W, Gallinger, Steven, Gaziano, J Michael, Giovannucci, Edward L, Goggins, Michael, González, Carlos A, Hallmans, Göran, Hankinson, Susan E, Hassan, Manal, Holly, Elizabeth A, Hunter, David J, Hutchinson, Amy, Jackson, Rebecca, Jacobs, Kevin B, Jenab, Mazda, Kaaks, Rudolf, Klein, Alison P, Kooperberg, Charles, Kurtz, Robert C, Li, Donghui, Lynch, Shannon M, Mandelson, Margaret, McWilliams, Robert R, Mendelsohn, Julie B, Michaud, Dominique S, Olson, Sara H, Overvad, Kim, Patel, Alpa V, Peeters, Petra HM, Rajkovic, Aleksandar, Riboli, Elio, Risch, Harvey A, Shu, Xiao-Ou, Thomas, Gilles, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Van Den Eeden, Stephen K, Virtamo, Jarmo, Wactawski-Wende, Jean, Wolpin, Brian M, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Chanock, Stephen J, Hartge, Patricia, and Hoover, Robert N

Subjects
Chromosomes, Human, Pair 9, Humans, Pancreatic Neoplasms, Genetic Predisposition to Disease, ABO Blood-Group System, Logistic Models, Odds Ratio, Risk Factors, Case-Control Studies, Cohort Studies, Prospective Studies, Gene Frequency, Genotype, Haplotypes, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Alleles, Introns, United States, Female, Male, Genetic Variation, Genome-Wide Association Study, Prevention, Rare Diseases, Cancer, Genetics, Clinical Research, Pancreatic Cancer, Digestive Diseases, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

Published
2009

19. Perspectives on This Article from Ovarian Cancer Biomarker Performance in Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Specimens

Author

Cramer, Daniel W., primary, Bast, Robert C., primary, Berg, Christine D., primary, Diamandis, Eleftherios P., primary, Godwin, Andrew K., primary, Hartge, Patricia, primary, Lokshin, Anna E., primary, Lu, Karen H., primary, McIntosh, Martin W., primary, Mor, Gil, primary, Patriotis, Christos, primary, Pinsky, Paul F., primary, Thornquist, Mark D., primary, Scholler, Nathalie, primary, Skates, Steven J., primary, Sluss, Patrick M., primary, Srivastava, Sudhir, primary, Ward, David C., primary, Zhang, Zhen, primary, Zhu, Claire S., primary, and Urban, Nicole, primary

Published
2023
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20. Data from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer

Author

Zhu, Claire S., primary, Pinsky, Paul F., primary, Cramer, Daniel W., primary, Ransohoff, David F., primary, Hartge, Patricia, primary, Pfeiffer, Ruth M., primary, Urban, Nicole, primary, Mor, Gil, primary, Bast, Robert C., primary, Moore, Lee E., primary, Lokshin, Anna E., primary, McIntosh, Martin W., primary, Skates, Steven J., primary, Vitonis, Allison, primary, Zhang, Zhen, primary, Ward, David C., primary, Symanowski, James T., primary, Lomakin, Aleksey, primary, Fung, Eric T., primary, Sluss, Patrick M., primary, Scholler, Nathalie, primary, Lu, Karen H., primary, Marrangoni, Adele M., primary, Patriotis, Christos, primary, Srivastava, Sudhir, primary, Buys, Saundra S., primary, and Berg, Christine D., primary

Published
2023
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21. Supplementary Materials from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer

Author

Zhu, Claire S., primary, Pinsky, Paul F., primary, Cramer, Daniel W., primary, Ransohoff, David F., primary, Hartge, Patricia, primary, Pfeiffer, Ruth M., primary, Urban, Nicole, primary, Mor, Gil, primary, Bast, Robert C., primary, Moore, Lee E., primary, Lokshin, Anna E., primary, McIntosh, Martin W., primary, Skates, Steven J., primary, Vitonis, Allison, primary, Zhang, Zhen, primary, Ward, David C., primary, Symanowski, James T., primary, Lomakin, Aleksey, primary, Fung, Eric T., primary, Sluss, Patrick M., primary, Scholler, Nathalie, primary, Lu, Karen H., primary, Marrangoni, Adele M., primary, Patriotis, Christos, primary, Srivastava, Sudhir, primary, Buys, Saundra S., primary, and Berg, Christine D., primary

Published
2023
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23. Perspectives on This Article from A Framework for Evaluating Biomarkers for Early Detection: Validation of Biomarker Panels for Ovarian Cancer

Author

Zhu, Claire S., primary, Pinsky, Paul F., primary, Cramer, Daniel W., primary, Ransohoff, David F., primary, Hartge, Patricia, primary, Pfeiffer, Ruth M., primary, Urban, Nicole, primary, Mor, Gil, primary, Bast, Robert C., primary, Moore, Lee E., primary, Lokshin, Anna E., primary, McIntosh, Martin W., primary, Skates, Steven J., primary, Vitonis, Allison, primary, Zhang, Zhen, primary, Ward, David C., primary, Symanowski, James T., primary, Lomakin, Aleksey, primary, Fung, Eric T., primary, Sluss, Patrick M., primary, Scholler, Nathalie, primary, Lu, Karen H., primary, Marrangoni, Adele M., primary, Patriotis, Christos, primary, Srivastava, Sudhir, primary, Buys, Saundra S., primary, and Berg, Christine D., primary

Published
2023
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24. Data from Ovarian Cancer Biomarker Performance in Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Specimens

Author

Cramer, Daniel W., primary, Bast, Robert C., primary, Berg, Christine D., primary, Diamandis, Eleftherios P., primary, Godwin, Andrew K., primary, Hartge, Patricia, primary, Lokshin, Anna E., primary, Lu, Karen H., primary, McIntosh, Martin W., primary, Mor, Gil, primary, Patriotis, Christos, primary, Pinsky, Paul F., primary, Thornquist, Mark D., primary, Scholler, Nathalie, primary, Skates, Steven J., primary, Sluss, Patrick M., primary, Srivastava, Sudhir, primary, Ward, David C., primary, Zhang, Zhen, primary, Zhu, Claire S., primary, and Urban, Nicole, primary

Published
2023
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26. Supplementary Table 1 from Eighteen Insulin-like Growth Factor Pathway Genes, Circulating Levels of IGF-I and Its Binding Protein, and Risk of Prostate and Breast Cancer

Author

Gu, Fangyi, primary, Schumacher, Fredrick R., primary, Canzian, Federico, primary, Allen, Naomi E., primary, Albanes, Demetrius, primary, Berg, Christine D., primary, Berndt, Sonja I., primary, Boeing, Heiner, primary, Bueno-de-Mesquita, H. Bas, primary, Buring, Julie E., primary, Chabbert-Buffet, Nathalie, primary, Chanock, Stephen J., primary, Clavel-Chapelon, Françoise, primary, Dumeaux, Vanessa, primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Haiman, Christopher A., primary, Hankinson, Susan E., primary, Hayes, Richard B., primary, Henderson, Brian E., primary, Hunter, David J., primary, Hoover, Robert N., primary, Johansson, Mattias, primary, Key, Timothy J., primary, Khaw, Kay-Tee, primary, Kolonel, Laurence N., primary, Lagiou, Pagona, primary, Lee, I-Min, primary, LeMarchand, Loic, primary, Lund, Eiliv, primary, Ma, Jing, primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Rodriguez, Laudina, primary, Sacerdote, Carlotta, primary, Sánchez, Maria-José, primary, Stampfer, Meir J., primary, Stattin, Pär, primary, Stram, Daniel O., primary, Thomas, Gilles, primary, Thun, Michael J., primary, Tjønneland, Anne, primary, Trichopoulos, Dimitrios, primary, Tumino, Rosario, primary, Virtamo, Jarmo, primary, Weinstein, Stephanie J., primary, Willett, Walter C., primary, Yeager, Meredith, primary, Zhang, Shumin M., primary, Kaaks, Rudolf, primary, Riboli, Elio, primary, Ziegler, Regina G., primary, and Kraft, Peter, primary

Published
2023
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28. The efficacy of prostate‐specific antigen screening: Impact of key components in the ERSPC and PLCO trials

Author

de Koning, Harry J., Gulati, Roman, Moss, Sue M., Hugosson, Jonas, Pinsky, Paul F., Berg, Christine D., Auvinen, Anssi, Andriole, Gerald L., Roobol, Monique J., Crawford, E. David, Nelen, Vera, Kwiatkowski, Maciej, Zappa, Marco, Luján, Marcos, Villers, Arnauld, de Carvalho, Tiago M., Feuer, Eric J., Tsodikov, Alex, Mariotto, Angela B., Heijnsdijk, Eveline A. M., and Etzioni, Ruth

Published
2018
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30. Body mass index and breast cancer survival: a Mendelian randomization analysis

Author

Guo, Qi, Burgess, Stephen, Turman, Constance, Bolla, Manjeet K, Wang, Qin, Lush, Michael, Abraham, Jean, Aittomäki, Kristiina, Andrulis, Irene L, Apicella, Carmel, Arndt, Volker, Barrdahl, Myrto, Benitez, Javier, Berg, Christine D, Blomqvist, Carl, Bojesen, Stig E, Bonanni, Bernardo, Brand, Judith S, Brenner, Hermann, Broeks, Annegien, Burwinkel, Barbara, Caldas, Carlos, Campa, Daniele, Canzian, Federico, Chang-Claude, Jenny, Chanock, Stephen J, Chin, Suet-Feung, Couch, Fergus J, Cox, Angela, Cross, Simon S, Cybulski, Cezary, Czene, Kamila, Darabi, Hatef, Devilee, Peter, Diver, Ryan W, Dunning, Alison M, Earl, Helena M, Eccles, Diana M, Ekici, Arif B, Eriksson, Mikael, Evans, Gareth D, Fasching, Peter A, Figueroa, Jonine, Flesch-Janys, Dieter, Flyger, Henrik, Gapstur, Susan M, Gaudet, Mia M, Giles, Graham G, Glendon, Gord, Grip, Mervi, Gronwald, Jacek, Haeberle, Lothar, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hankinson, Susan, Hartikainen, Jaana M, Hein, Alexander, Hiller, Louise, Hogervorst, Frans B, Holleczek, Bernd, Hooning, Maartje J, Hoover, Robert N, Humphreys, Keith, Hunter, David J, Hüsing, Anika, Jakubowska, Anna, Jukkola-Vuorinen, Arja, Kaaks, Rudolf, Kabisch, Maria, Kataja, Vesa, Knight, Julia A, Koppert, Linetta B, Kosma, Veli-Matti, Kristensen, Vessela N, Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lindström, Sara, Lissowska, Jolanta, Lubinski, Jan, Machiela, Mitchell J, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Marme, Federik, Martens, John WM, McLean, Catriona, Menéndez, Primitiva, Milne, Roger L, Marie Mulligan, Anna, Muranen, Taru A, Nevanlinna, Heli, Neven, Patrick, Nielsen, Sune F, Nordestgaard, Børge G, Olson, Janet E, Perez, Jose IA, Peterlongo, Paolo, Phillips, Kelly-Anne, Poole, Christopher J, Pylkäs, Katri, Radice, Paolo, Rahman, Nazneen, Rüdiger, Thomas, Rudolph, Anja, Sawyer, Elinor J, Schumacher, Fredrick, Seibold, Petra, Seynaeve, Caroline, Shah, Mitul, Smeets, Ann, Southey, Melissa C, Tollenaar, Rob A E M, Tomlinson, Ian, Tsimiklis, Helen, Ulmer, Hans-Ulrich, Vachon, Celine, van den Ouweland, Ans MW, Vanʼt Veer, Laura J, Wildiers, Hans, Willett, Walter, Winqvist, Robert, Zamora, Pilar M, Chenevix-Trench, Georgia, Dörk, Thilo, Easton, Douglas F, García-Closas, Montserrat, Kraft, Peter, Hopper, John L, Zheng, Wei, Schmidt, Marjanka K, and Pharoah, Paul DP

Published
2017
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31. Transitioning to Environmentally Sustainable, Climate-Smart Radiation Oncology Care

Author

Lichter, Katie E., primary, Anderson, Justin, additional, Sim, Austin J., additional, Baniel, Claire C., additional, Thiel, Cassandra L., additional, Chuter, Robert, additional, Collins, Amy, additional, Carollo, Erin, additional, Berg, Christine D, additional, Coleman, C. Norman, additional, Abdel-Wahab, May, additional, Grover, Surbhi, additional, Singer, Lisa, additional, and Mohamad, Osama, additional

Published
2022
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32. Abstract 2232: Preliminary results for a novel single extracellular vesicle assay for early lung cancer: The power of co-localized detection of surface biomarkers

Author

Salem, Daniel P., primary, Bortolin, Laura T., additional, Banerjee, Sanchari, additional, Biette, Kelly M., additional, Byrne, Delaney M., additional, Couvillon, Anthony D., additional, Duff, Peter A., additional, Grosha, Jonian, additional, Gusenleitner, Daniel, additional, King, MacKenzie Sadie, additional, Sedlak, Christopher R., additional, Zabroski, Ibukunoluwapo O., additional, Copeland, Karen, additional, Winn-Deen, Emily S., additional, Huang, Eric K., additional, Berg, Christine D., additional, and Sedlak, Joseph C., additional

Published
2022
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33. Reconciling the Effects of Screening on Prostate Cancer Mortality in the ERSPC and PLCO Trials

Author

Tsodikov, Alex, Gulati, Roman, Heijnsdijk, Eveline A.M., Pinsky, Paul F., Moss, Sue M., Qiu, Sheng, de Carvalho, Tiago M., Hugosson, Jonas, Berg, Christine D., Auvinen, Anssi, Andriole, Gerald L., Roobol, Monique J., Crawford, E. David, Nelen, Vera, Kwiatkowski, Maciej, Zappa, Marco, Luján, Marcos, Villers, Arnauld, Feuer, Eric J., de Koning, Harry J., Mariotto, Angela B., and Etzioni, Ruth

Published
2017

35. Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Author

Robbins, Hilary A, primary, Alcala, Karine, additional, Khodayari Moez, Elham, additional, Guida, Florence, additional, Thomas, Sera, additional, Zahed, Hana, additional, Warkentin, Matthew, additional, Smith-Byrne, Karl, additional, Brhane, Yonathan, additional, Muller, David, additional, Albanes, Demetrius, additional, Aldrich, Melinda C, additional, Arslan, Alan A, additional, Bassett, Julie, additional, Berg, Christine D, additional, Cai, Qiuyin, additional, Chen, Chu, additional, Davies, Michael PA, additional, Diergaarde, Brenda, additional, Field, John K, additional, Freedman, Neal D, additional, Huang, Wen-Yi, additional, Johansson, Mikael, additional, Jones, Michael, additional, Koh, Woon-Puay, additional, Lam, Stephen, additional, Lan, Qing, additional, Langhammer, Arnulf, additional, Liao, Linda M, additional, Liu, Geoffrey, additional, Malekzadeh, Reza, additional, Milne, Roger L, additional, Montuenga, Luis M, additional, Rohan, Thomas, additional, Sesso, Howard D, additional, Severi, Gianluca, additional, Sheikh, Mahdi, additional, Sinha, Rashmi, additional, Shu, Xiao-Ou, additional, Stevens, Victoria L, additional, Tammemägi, Martin C, additional, Tinker, Lesley F, additional, Visvanathan, Kala, additional, Wang, Ying, additional, Wang, Renwei, additional, Weinstein, Stephanie J, additional, White, Emily, additional, Wilson, David, additional, Yuan, Jian-Min, additional, Zhang, Xuehong, additional, Zheng, Wei, additional, Amos, Christopher I, additional, Brennan, Paul, additional, Johansson, Mattias, additional, and Hung, Rayjean J, additional

Published
2022
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37. Leveraging Biospecimen Resources for Discovery or Validation of Markers for Early Cancer Detection

Author

Schully, Sheri D., Carrick, Danielle M., Mechanic, Leah E., Srivastava, Sudhir, Anderson, Garnet L., Baron, John A., Berg, Christine D., Cullen, Jennifer, Diamandis, Eleftherios P., Doria-Rose, V. Paul, Goddard, Katrina A. B., Hankinson, Susan E., Kushi, Lawrence H., Larson, Eric B., McShane, Lisa M., Schilsky, Richard L., Shak, Steven, Skates, Steven J., Urban, Nicole, Kramer, Barnett S., Khoury, Muin J., and Ransohoff, David F.

Published
2015
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42. Additive Interactions Between Susceptibility Single-Nucleotide Polymorphisms Identified in Genome-Wide Association Studies and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium

Author

Joshi, Amit D., Lindström, Sara, Hüsing, Anika, Barrdahl, Myrto, VanderWeele, Tyler J., Campa, Daniele, Canzian, Federico, Gaudet, Mia M., Figueroa, Jonine D., Baglietto, Laura, Berg, Christine D., Buring, Julie E., Chanock, Stephen J., Chirlaque, María-Dolores, Diver, W. Ryan, Dossus, Laure, Giles, Graham G., Haiman, Christopher A., Hankinson, Susan E., Henderson, Brian E., Hoover, Robert N., Hunter, David J., Isaacs, Claudine, Kaaks, Rudolf, Kolonel, Laurence N., Krogh, Vittorio, Le Marchand, Loic, Lee, I-Min, Lund, Eiliv, McCarty, Catherine A., Overvad, Kim, Peeters, Petra H., Riboli, Elio, Schumacher, Fredrick, Severi, Gianluca, Stram, Daniel O., Sund, Malin, Thun, Michael J., Travis, Ruth C., Trichopoulos, Dimitrios, Willett, Walter C., Zhang, Shumin, Ziegler, Regina G., Kraft, Peter, Joshi, Amit D., Lindström, Sara, Hunter, David J., Kraft, Peter, Hüsing, Anika, Barrdahl, Myrto, Kaaks, Rudolf, Kraft, Peter, VanderWeele, Tyler J., Trichopoulos, Dimitrios, Campa, Daniele, VanderWeele, Tyler J., Campa, Daniele, Canzian, Federico, Gaudet, Mia M., Figueroa, Jonine D., Chanock, Stephen J., Hoover, Robert N., Ziegler, Regina G., Baglietto, Laura, Giles, Graham G., Severi, Gianluca, Baglietto, Laura, Giles, Graham G., Severi, Gianluca, Berg, Christine D., Buring, Julie E., Lee, I-Min, Zhang, Shumin, Chirlaque, María-Dolores, Chirlaque, María-Dolores, Diver, W. Ryan, Thun, Michael J., Dossus, Laure, Dossus, Laure, Giles, Graham G., Haiman, Christopher A., Schumacher, Fredrick, Stram, Daniel O., Henderson, Brian E., Hankinson, Susan E., Isaacs, Claudine, Kolonel, Laurence N., Krogh, Vittorio, Marchand, Loic Le, Lund, Eiliv, McCarty, Catherine A., Overvad, Kim, Peeters, Petra H., Peeters, Petra H., Riboli, Elio, Sund, Malin, Travis, Ruth C., Trichopoulos, Dimitrios, Trichopoulos, Dimitrios, and Willett, Walter C.

Published
2014
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48. ABO Blood Group Alleles and Prostate Cancer Risk: Results from the Breast and Prostate Cancer Cohort Consortium (BPC3)

Author

Markt, Sarah C., Shui, Irene M., Unger, Robert H., Urun, Yuksel, Berg, Christine D., Black, Amanda, Brennan, Paul, Bueno-de-Mesquita, Bas H., Gapstur, Susan M., Giovannucci, Edward, Haiman, Christopher, Henderson, Brian, Hoover, Robert N., Hunter, David J., Key, Timothy J., Khaw, Kay-Tee, Canzian, Federico, Larranga, Nerea, Le Marchand, Loic, Ma, Jing, Naccarati, Alessio, Siddiq, Afshan, Stampfer, Meir J., Stattin, Par, Stevens, Victoria L., Stram, Daniel O., Tjnneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Ziegler, Regina G., Lindstrom, Sara, Kraft, Peter, Mucci, Lorelei A., Choueiri, Toni K., and Wilson, Kathryn M.

Published
2015
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49. Fine mapping of 14q24.1 breast cancer susceptibility locus

Author

Lee, Phoebe, Fu, Yi-Ping, Figueroa, Jonine D., Prokunina-Olsson, Ludmila, Gonzalez-Bosquet, Jesus, Kraft, Peter, Wang, Zhaoming, Jacobs, Kevin B., Yeager, Meredith, Horner, Marie-Josèphe, Hankinson, Susan E., Hutchinson, Amy, Chatterjee, Nilanjan, Garcia-Closas, Montserrat, Ziegler, Regina G., Berg, Christine D., Buys, Saundra S., McCarty, Catherine A., Feigelson, Heather Spencer, Thun, Michael J., Diver, Ryan, Prentice, Ross, Jackson, Rebecca, Kooperberg, Charles, Chlebowski, Rowan, Lissowska, Jolanta, Peplonska, Beata, Brinton, Louise A., Tucker, Margaret, Fraumeni, Jr., Joseph F., Hoover, Robert N., Thomas, Gilles, Hunter, David J., and Chanock, Stephen J.

Published
2012
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