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202 results on '"Berendes, R"'

1. Unravelling the clinical heterogeneity of undefined recurrent fever over time in the European registries on Autoinflammation

Author

Vyzhga, Y., Wittkowski, H., Hentgen, V., Georgin-Lavialle, S., Theodoropoulou, A., Fuehner, S., Jesenak, M., Frenkel, J., Papadopoulou-Alataki, E., Anton, Jordi, Olivieri, A. Nunzia, Brunner, J., Sanchez, J., Koné-Paut, I., Fingerhutova, S., Pillet, P., Meinzer, U., Khubchandani, R., Jansson, A., Haas, J.-P., Berendes, R., Kallinich, T., Horneff, G., Lilienthal, E., Papa, R., Foell, D., Lainka, E., Caorsi, R., Gattorno, M., and Hofer, M.

Published
2024
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2. The Design, Construction, and Commissioning of the KATRIN Experiment

Author

Aker, M., Altenmüller, K., Amsbaugh, J. F., Arenz, M., Babutzka, M., Bast, J., Bauer, S., Bechtler, H., Beck, M., Beglarian, A., Behrens, J., Bender, B., Berendes, R., Berlev, A., Besserer, U., Bettin, C., Bieringer, B., Blaum, K., Block, F., Bobien, S., Bohn, J., Bokeloh, K., Bolz, H., Bornschein, B., Bornschein, L., Böttcher, M., Bouquet, H., Boyd, N. M., Brunst, T., Burritt, T. H., Caldwell, T. S., Chaoui, Z., Chilingaryan, S., Choi, W., Corona, T. J., Cox, G. A., Debowski, K., Deffert, M., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Dunmore, J. A., Dyba, S., Edzards, F., Eichelhardt, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Erhard, M., Eversheim, D., Fedkevych, M., Felden, A., Fischer, S., Formaggio, J. A., Fränkle, F. M., Franklin, G. B., Frenzel, H., Friedel, F., Fulst, A., Gauda, K., Gehring, R., Gil, W., Glück, F., Görhardt, S., Grimm, J., Grohmann, S., Groh, S., Grössle, R., Gumbsheimer, R., Hackenjos, M., Häßler, D., Hannen, V., Harms, F., Harper, G. C., Hartmann, J., Haußmann, N., Heizmann, F., Helbing, K., Held, M., Hickford, S., Hilk, D., Hillen, B., Hiller, R., Hillesheimer, D., Hinz, D., Höhn, T., Holzmann, S., Horn, S., Hötzel, M., Houdy, T., Howe, M. A., Huber, A., James, T., Jansen, A., Kaiser, M., Karl, C., Kazachenko, O., Kellerer, J., Kippenbrock, L., Kleesiek, M., Kleifges, M., Kleinfeller, J., Klein, M., Köllenberger, L., Kopmann, A., Korzeczek, M., Kosmider, A., Kovalík, A., Krasch, B., Krause, H., Kraus, M., Kuckert, L., Kumb, A., Kunka, N., Lasserre, T., La Cascio, L., Lebeda, O., Leber, M. L., Lehnert, B., Leiber, B., Letnev, J., Lewis, R. J., Le, T. L., Lichter, S., Lokhov, A., Poyato, J. M. Lopez, Machatschek, M., Malcherek, E., Mark, M., Marsteller, A., Martin, E. L., Mehret, K., Meloni, M., Melzer, C., Menshikov, A., Mertens, S., Minter, L. I., Monreal, B., Mostafa, J., Müller, K., Myers, A. W., Naumann, U., Neumann, H., Niemes, S., Oelpmann, P., Off, A., Ortjohann, H. -W., Osipowicz, A., Ostrick, B., Parno, D. S., Peterson, D. A., Plischke, P., Poon, A. W. P., Prall, M., Priester, F., Ranitzsch, P. C. -O., Reich, J., Renschler, P., Rest, O., Rinderspacher, R., Robertson, R. G. H., Rodejohann, W., Rodenbeck, C., Rohr, P., Röllig, M., Röttele, C., Rupp, S., Ryšavý, M., Sack, R., Saenz, A., Sagawe, M., Schäfer, P., Schaller, A., Schimpf, L., Schlösser, K., Schlösser, M., Schlüter, L., Schneidewind, S., Schön, H., Schönung, K., Schrank, M., Schulz, B., Schwarz, J., Šefčík, M., Seitz-Moskaliuk, H., Seller, W., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Sturm, M., Sun, M., Tcherniakhovski, D., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Trost, N., Valerius, K., VanDevender, B. A., Van Wechel, T. D., Vénos, D., Verbeek, A., Vianden, R., Hernández, A. P. Vizcaya, Vogt, K., Wall, B. L., Wandkowsky, N., Weber, M., Weingardt, H., Weinheimer, C., Weiss, C., Welte, S., Wendel, J., Wierman, K. J., Wilkerson, J. F., Wolf, J., Wüstling, S., Xu, W., Yen, Y. -R., Zacher, M., Zadoroghny, S., Zboril, M., and Zeller, G.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The KArlsruhe TRItium Neutrino (KATRIN) experiment, which aims to make a direct and model-independent determination of the absolute neutrino mass scale, is a complex experiment with many components. More than 15 years ago, we published a technical design report (TDR) [https://publikationen.bibliothek.kit.edu/270060419] to describe the hardware design and requirements to achieve our sensitivity goal of 0.2 eV at 90% C.L. on the neutrino mass. Since then there has been considerable progress, culminating in the publication of first neutrino mass results with the entire beamline operating [arXiv:1909.06048]. In this paper, we document the current state of all completed beamline components (as of the first neutrino mass measurement campaign), demonstrate our ability to reliably and stably control them over long times, and present details on their respective commissioning campaigns., Comment: Added missing acknowledgement, corrected performance statement in chapter 4.2.5, updated author list and references

Published
2021
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3. The design, construction, and commissioning of the KATRIN experiment

Author

Aker, M, Altenmüller, K, Amsbaugh, JF, Arenz, M, Babutzka, M, Bast, J, Bauer, S, Bechtler, H, Beck, M, Beglarian, A, Behrens, J, Bender, B, Berendes, R, Berlev, A, Besserer, U, Bettin, C, Bieringer, B, Blaum, K, Block, F, Bobien, S, Böttcher, M, Bohn, J, Bokeloh, K, Bolz, H, Bornschein, B, Bornschein, L, Bouquet, H, Boyd, NM, Brunst, T, Burritt, TH, Caldwell, TS, Chaoui, Z, Chilingaryan, S, Choi, W, Corona, TJ, Cox, GA, Debowski, K, Deffert, M, Descher, M, Barrero, D Díaz, Doe, PJ, Dragoun, O, Drexlin, G, Dunmore, JA, Dyba, S, Edzards, F, Eichelhardt, F, Eitel, K, Ellinger, E, Engel, R, Enomoto, S, Erhard, M, Eversheim, D, Fedkevych, M, Felden, A, Fischer, S, Formaggio, JA, Fränkle, FM, Franklin, GB, Frenzel, H, Friedel, F, Fulst, A, Gauda, K, Gehring, R, Gil, W, Glück, F, Görhardt, S, Grimm, J, Grössle, R, Groh, S, Grohmann, S, Gumbsheimer, R, Hackenjos, M, Häßler, D, Hannen, V, Harms, F, Harper, GC, Hartmann, J, Haußmann, N, Heizmann, F, Helbing, K, Held, M, Hickford, S, Hilk, D, Hillen, B, Hiller, R, Hillesheimer, D, Hinz, D, Höhn, T, Hötzel, M, Holzmann, S, Horn, S, Houdy, T, Howe, MA, Huber, A, James, T, Jansen, A, Kaiser, M, Karl, C, and Kazachenko, O

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Beam-line instrumentation, Spectrometers, Gas systems and purification, Neutrino detectors, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract

The KArlsruhe TRItium Neutrino (KATRIN) experiment, which aims to make a direct and model-independent determination of the absolute neutrino mass scale, is a complex experiment with many components. More than 15 years ago, we published a technical design report (TDR) [1] to describe the hardware design and requirements to achieve our sensitivity goal of 0.2 eV at 90% C.L. on the neutrino mass. Since then there has been considerable progress, culminating in the publication of first neutrino mass results with the entire beamline operating [2]. In this paper, we document the current state of all completed beamline components (as of the first neutrino mass measurement campaign), demonstrate our ability to reliably and stably control them over long times, and present details on their respective commissioning campaigns.

Published
2021

4. A novel ppm-precise absolute calibration method for precision high-voltage dividers

Author

Rest, O., Winzen, D., Bauer, S., Berendes, R., Meisner, J., Thümmler, T., Wüstling, S., and Weinheimer, C.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The most common method to measure direct current high voltage (HV) down to the ppm-level is to use resistive high-voltage dividers. Such devices scale the HV into a range where it can be compared with precision digital voltmeters to reference voltages sources, which can be traced back to Josephson voltage standards. So far the calibration of the scale factors of HV dividers for voltages above 1~kV could only be done at metrology institutes and sometimes involves round-robin tests among several institutions to get reliable results. Here we present a novel absolute calibration method based on the measurement of a differential scale factor, which can be performed with commercial equipment and outside metrology institutes. We demonstrate that reproducible measurements up to 35~kV can be performed with relative uncertainties below $1\cdot10^{-6}$. This method is not restricted to metrology institutes and offers the possibility to determine the linearity of high-voltage dividers for a wide range of applications., Comment: 9 pages, 13 figures

Published
2019
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5. Reduction of stored-particle background by a magnetic pulse method at the KATRIN experiment

Author

KATRIN Collaboration, Arenz, M., Baek, W. -J., Bauer, S., Beck, M., Beglarian, A., Behrens, J., Berendes, R., Bergmann, T., Berlev, A., Besserer, U., Blaum, K., Bode, T., Bornschein, B., Bornschein, L., Brunst, T., Buglak, W., Buzinsky, N., Chilingaryan, S., Choi, W. Q., Deffert, M., Doe, P. J., Dragoun, O., Drexlin, G., Dyba, S., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Erhard, M., Eversheim, D., Fedkevych, M., Formaggio, J. A., Fränkle, F. M., Franklin, G. B., Friedel, F., Fulst, A., Furse, D., Gil, W., Glück, F., Urena, A. Gonzalez, Grohmann, S., Grössle, R., Gumbsheimer, R., Hackenjos, M., Hannen, V., Harms, F., Haußmann, N., Heizmann, F., Helbing, K., Herz, W., Hickford, S., Hilk, D., Howe, M. A., Huber, A., Jansen, A., Kellerer, J., Kernert, N., Kippenbrock, L., Kleesiek, M., Klein, M., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Kraus, M., Kuckert, L., Lasserre, T., Lebeda, O., Letnev, J., Lokhov, A., Machatschek, M., Marsteller, A., Martin, E. L., Mertens, S., Mirz, S., Monreal, B., Neumann, H., Niemes, S., Off, A., Osipowicz, A., Otten, E., Parno, D. S., Pollithy, A., Poon, A. W. P., Priester, F., Ranitzsch, P. C. -O., Rest, O., Robertson, R. G. H., Roccati, F., Rodenbeck, C., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Schimpf, L., Schlösser, K., Schlösser, M., Schönung, K., Schrank, M., Seitz-Moskaliuk, H., Sentkerestiová, J., Sibille, V., Slezák, M., Steidl, M., Steinbrink, N., Sturm, M., Suchopar, M., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Trost, N., Valerius, K., Vénos, D., Vianden, R., Hernández, A. P. Vizcaya, Wandkowsky, N., Weber, M., Weinheimer, C., Weiss, C., Welte, S., Wendel, J., Wilkerson, J. F., Wolf, J., Wüstling, S., and Zadoroghny, S.

Subjects
Physics - Instrumentation and Detectors
Abstract

The KATRIN experiment aims to determine the effective electron neutrino mass with a sensitivity of $0.2\,{\text{eV}/c^2}$ (90\% C.L.) by precision measurement of the shape of the tritium \textbeta-spectrum in the endpoint region. The energy analysis of the decay electrons is achieved by a MAC-E filter spectrometer. A common background source in this setup is the decay of short-lived isotopes, such as $\textsuperscript{219}$Rn and $\textsuperscript{220}$Rn, in the spectrometer volume. Active and passive countermeasures have been implemented and tested at the KATRIN main spectrometer. One of these is the magnetic pulse method, which employs the existing air coil system to reduce the magnetic guiding field in the spectrometer on a short timescale in order to remove low- and high-energy stored electrons. Here we describe the working principle of this method and present results from commissioning measurements at the main spectrometer. Simulations with the particle-tracking software Kassiopeia were carried out to gain a detailed understanding of the electron storage conditions and removal processes., Comment: 16 pages, 9 figures, 4 tables

Published
2018
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6. Technical design and commissioning of the KATRIN large-volume air coil system

Author

Erhard, M., Behrens, J., Bauer, S., Beglarian, A., Berendes, R., Drexlin, G., Glück, F., Gumbsheimer, R., Hergenhan, J., Leiber, B., Mertens, S., Osipowicz, A., Plischke, P., Reich, J., Thümmler, T., Wandkowsky, N., Weinheimer, C., and Wüstling, S.

Subjects
Physics - Instrumentation and Detectors
Abstract

The KATRIN experiment is a next-generation direct neutrino mass experiment with a sensitivity of 0.2 eV (90% C.L.) to the effective mass of the electron neutrino. It measures the tritium $\beta$-decay spectrum close to its endpoint with a spectrometer based on the MAC-E filter technique. The $\beta$-decay electrons are guided by a magnetic field that operates in the mT range in the central spectrometer volume; it is fine-tuned by a large-volume air coil system surrounding the spectrometer vessel. The purpose of the system is to provide optimal transmission properties for signal electrons and to achieve efficient magnetic shielding against background. In this paper we describe the technical design of the air coil system, including its mechanical and electrical properties. We outline the importance of its versatile operation modes in background investigation and suppression techniques. We compare magnetic field measurements in the inner spectrometer volume during system commissioning with corresponding simulations, which allows to verify the system's functionality in fine-tuning the magnetic field configuration. This is of major importance for a successful neutrino mass measurement at KATRIN., Comment: 32 pages, 16 figures

Published
2017
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7. Reduction of stored-particle background by a magnetic pulse method at the KATRIN experiment

Author

Arenz, M, Baek, W-J, Bauer, S, Beck, M, Beglarian, A, Behrens, J, Berendes, R, Bergmann, T, Berlev, A, Besserer, U, Blaum, K, Bode, T, Bornschein, B, Bornschein, L, Brunst, T, Buglak, W, Buzinsky, N, Chilingaryan, S, Choi, WQ, Deffert, M, Doe, PJ, Dragoun, O, Drexlin, G, Dyba, S, Edzards, F, Eitel, K, Ellinger, E, Engel, R, Enomoto, S, Erhard, M, Eversheim, D, Fedkevych, M, Formaggio, JA, Fränkle, FM, Franklin, GB, Friedel, F, Fulst, A, Furse, D, Gil, W, Glück, F, Ureña, A Gonzalez, Grohmann, S, Grössle, R, Gumbsheimer, R, Hackenjos, M, Hannen, V, Harms, F, Haußmann, N, Heizmann, F, Helbing, K, Herz, W, Hickford, S, Hilk, D, Howe, MA, Huber, A, Jansen, A, Kellerer, J, Kernert, N, Kippenbrock, L, Kleesiek, M, Klein, M, Kopmann, A, Korzeczek, M, Kovalík, A, Krasch, B, Kraus, M, Kuckert, L, Lasserre, T, Lebeda, O, Letnev, J, Lokhov, A, Machatschek, M, Marsteller, A, Martin, EL, Mertens, S, Mirz, S, Monreal, B, Neumann, H, Niemes, S, Off, A, Osipowicz, A, Otten, E, Parno, DS, Pollithy, A, Poon, AWP, Priester, F, Ranitzsch, PC-O, Rest, O, Robertson, RGH, Roccati, F, Rodenbeck, C, Röllig, M, Röttele, C, Ryšavý, M, Sack, R, Saenz, A, Schimpf, L, Schlösser, K, Schlösser, M, and Schönung, K

Subjects
Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, physics.ins-det, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics
Abstract

The KATRIN experiment aims to determine the effective electron neutrino mass with a sensitivity of 0.2eV/c2 (%90 CL) by precision measurement of the shape of the tritium β -spectrum in the endpoint region. The energy analysis of the decay electrons is achieved by a MAC-E filter spectrometer. A common background source in this setup is the decay of short-lived isotopes, such as 219Rn and 220Rn , in the spectrometer volume. Active and passive countermeasures have been implemented and tested at the KATRIN main spectrometer. One of these is the magnetic pulse method, which employs the existing air coil system to reduce the magnetic guiding field in the spectrometer on a short timescale in order to remove low- and high-energy stored electrons. Here we describe the working principle of this method and present results from commissioning measurements at the main spectrometer. Simulations with the particle-tracking software Kassiopeia were carried out to gain a detailed understanding of the electron storage conditions and removal processes.

Published
2018

8. Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Author

CBM Collaboration, Ablyazimov, T., Abuhoza, A., Adak, R. P., Adamczyk, M., Agarwal, K., Aggarwal, M. M., Ahammed, Z., Ahmad, F., Ahmad, N., Ahmad, S., Akindinov, A., Akishin, P., Akishina, E., Akishina, T., Akishina, V., Akram, A., Al-Turany, M., Alekseev, I., Alexandrov, E., Alexandrov, I., Amar-Youcef, S., Anđelić, M., Andreeva, O., Andrei, C., Andronic, A., Anisimov, Yu., Appelshäuser, H., Argintaru, D., Atkin, E., Avdeev, S., Averbeck, R., Azmi, M. D., Baban, V., Bach, M., Badura, E., Bähr, S., Balog, T., Balzer, M., Bao, E., Baranova, N., Barczyk, T., Bartoş, D., Bashir, S., Baszczyk, M., Batenkov, O., Baublis, V., Baznat, M., Becker, J., Becker, K. -H., Belogurov, S., Belyakov, D., Bendarouach, J., Berceanu, I., Bercuci, A., Berdnikov, A., Berdnikov, Y., Berendes, R., Berezin, G., Bergmann, C., Bertini, D., Bertini, O., Beşliu, C., Bezshyyko, O., Bhaduri, P. P., Bhasin, A., Bhati, A. K., Bhattacharjee, B., Bhattacharyya, A., Bhattacharyya, T. K., Biswas, S., Blank, T., Blau, D., Blinov, V., Blume, C., Bocharov, Yu., Book, J., Breitner, T., Brüning, U., Brzychczyk, J., Bubak, A., Büsching, H., Bus, T., Butuzov, V., Bychkov, A., Byszuk, A., Cai, Xu, Cálin, M., Cao, Ping, Caragheorgheopol, G., Carević, I., Cătănescu, V., Chakrabarti, A., Chattopadhyay, S., Chaus, A., Chen, Hongfang, Chen, LuYao, Cheng, Jianping, Chepurnov, V., Cherif, H., Chernogorov, A., Ciobanu, M. I., Claus, G., Constantin, F., Csanád, M., D'Ascenzo, N., Das, Supriya, Das, Susovan, de Cuveland, J., Debnath, B., Dementiev, D., Deng, Wendi, Deng, Zhi, Deppe, H., Deppner, I., Derenovskaya, O., Deveaux, C. A., Deveaux, M., Dey, K., Dey, M., Dillenseger, P., Dobyrn, V., Doering, D., Dong, Sheng, Dorokhov, A., Dreschmann, M., Drozd, A., Dubey, A. K., Dubnichka, S., Dubnichkova, Z., Dürr, M., Dutka, L., Dželalija, M., Elsha, V. V., Emschermann, D., Engel, H., Eremin, V., Eşanu, T., Eschke, J., Eschweiler, D., Fan, Huanhuan, Fan, Xingming, Farooq, M., Fateev, O., Feng, Shengqin, Figuli, S. P. D., Filozova, I., Finogeev, D., Fischer, P., Flemming, H., Förtsch, J., Frankenfeld, U., Friese, V., Friske, E., Fröhlich, I., Frühauf, J., Gajda, J., Galatyuk, T., Gangopadhyay, G., Chávez, C. García, Gebelein, J., Ghosh, P., Ghosh, S. K., Gläßel, S., Goffe, M., Golinka-Bezshyyko, L., Golovatyuk, V., Golovnya, S., Golovtsov, V., Golubeva, M., Golubkov, D., Ramírez, A. Gómez, Gorbunov, S., Gorokhov, S., Gottschalk, D., Gryboś, P., Grzeszczuk, A., Guber, F., Gudima, K., Gumiński, M., Gupta, A., Gusakov, Yu., Han, Dong, Hartmann, H., He, Shue, Hehner, J., Heine, N., Herghelegiu, A., Herrmann, N., Heß, B., Heuser, J. M., Himmi, A., Höhne, C., Holzmann, R., Hu, Dongdong, Huang, Guangming, Huang, Xinjie, Hutter, D., Ierusalimov, A., Ilgenfritz, E. -M., Irfan, M., Ivanischev, D., Ivanov, M., Ivanov, P., Ivanov, Valery, Ivanov, Victor, Ivanov, Vladimir, Ivashkin, A., Jaaskelainen, K., Jahan, H., Jain, V., Jakovlev, V., Janson, T., Jiang, Di, Jipa, A., Kadenko, I., Kähler, P., Kämpfer, B., Kalinin, V., Kallunkathariyil, J., Kampert, K. -H., Kaptur, E., Karabowicz, R., Karavichev, O., Karavicheva, T., Karmanov, D., Karnaukhov, V., Karpechev, E., Kasiński, K., Kasprowicz, G., Kaur, M., Kazantsev, A., Kebschull, U., Kekelidze, G., Khan, M. M., Khan, S. A., Khanzadeev, A., Khasanov, F., Khvorostukhin, A., Kirakosyan, V., Kirejczyk, M., Kiryakov, A., Kiš, M., Kisel, I., Kisel, P., Kiselev, S., Kiss, T., Klaus, P., Kłeczek, R., Klein-Bösing, Ch., Kleipa, V., Klochkov, V., Kmon, P., Koch, K., Kochenda, L., Koczoń, P., Koenig, W., Kohn, M., Kolb, B. W., Kolosova, A., Komkov, B., Korolev, M., Korolko, I., Kotte, R., Kovalchuk, A., Kowalski, S., Koziel, M., Kozlov, G., Kozlov, V., Kramarenko, V., Kravtsov, P., Krebs, E., Kreidl, C., Kres, I., Kresan, D., Kretschmar, G., Krieger, M., Kryanev, A. V., Kryshen, E., Kuc, M., Kucewicz, W., Kucher, V., Kudin, L., Kugler, A., Kumar, Ajit, Kumar, Ashwini, Kumar, L., Kunkel, J., Kurepin, A., Kurepin, N., Kurilkin, A., Kurilkin, P., Kushpil, V., Kuznetsov, S., Kyva, V., Ladygin, V., Lara, C., Larionov, P., García, A. Laso, Lavrik, E., Lazanu, I., Lebedev, A., Lebedev, S., Lebedeva, E., Lehnert, J., Lehrbach, J., Leifels, Y., Lemke, F., Li, Cheng, Li, Qiyan, Li, Xin, Li, Yuanjing, Lindenstruth, V., Linnik, B., Liu, Feng, Lobanov, I., Lobanova, E., Löchner, S., Loizeau, P. -A., Lone, S. A., Martínez, J. A. Lucio, Luo, Xiaofeng, Lymanets, A., Lyu, Pengfei, Maevskaya, A., Mahajan, S., Mahapatra, D. P., Mahmoud, T., Maj, P., Majka, Z., Malakhov, A., Malankin, E., Malkevich, D., Malyatina, O., Malygina, H., Mandal, M. M., Mandal, S., Manko, V., Manz, S., Garcia, A. M. Marin, Markert, J., Masciocchi, S., Matulewicz, T., Meder, L., Merkin, M., Mialkovski, V., Michel, J., Miftakhov, N., Mik, L., Mikhailov, K., Mikhaylov, V., Milanović, B., Militsija, V., Miskowiec, D., Momot, I., Morhardt, T., Morozov, S., Müller, W. F. J., Müntz, C., Mukherjee, S., Castillo, C. E. Muńoz, Murin, Yu., Najman, R., Nandi, C., Nandy, E., Naumann, L., Nayak, T., Nedosekin, A., Negi, V. S., Niebur, W., Nikulin, V., Normanov, D., Oancea, A., Oh, Kunsu, Onishchuk, Yu., Ososkov, G., Otfinowski, P., Ovcharenko, E., Pal, S., Panasenko, I., Panda, N. R., Parzhitskiy, S., Patel, V., Pauly, C., Penschuck, M., Peshekhonov, D., Peshekhonov, V., Petráček, V., Petri, M., Petriş, M., Petrovici, A., Petrovici, M., Petrovskiy, A., Petukhov, O., Pfeifer, D., Piasecki, K., Pieper, J., Pietraszko, J., Płaneta, R., Plotnikov, V., Plujko, V., Pluta, J., Pop, A., Pospisil, V., Poźniak, K., Prakash, A., Prasad, S. K., Prokudin, M., Pshenichnov, I., Pugach, M., Pugatch, V., Querchfeld, S., Rabtsun, S., Radulescu, L., Raha, S., Rami, F., Raniwala, R., Raniwala, S., Raportirenko, A., Rautenberg, J., Rauza, J., Ray, R., Razin, S., Reichelt, P., Reinecke, S., Reinefeld, A., Reshetin, A., Ristea, C., Ristea, O., Rodriguez, A. Rodriguez, Roether, F., Romaniuk, R., Rost, A., Rostchin, E., Rostovtseva, I., Roy, Amitava, Roy, Ankhi, Rożynek, J., Ryabov, Yu., Sadovsky, A., Sahoo, R., Sahu, P. K., Sahu, S. K., Saini, J., Samanta, S., Sambyal, S. S., Samsonov, V., Rosado, J. Sánchez, Sander, O., Sarangi, S., Satława, T., Sau, S., Saveliev, V., Schatral, S., Schiaua, C., Schintke, F., Schmidt, C. J., Schmidt, H. R., Schmidt, K., Scholten, J., Schweda, K., Seck, F., Seddiki, S., Selyuzhenkov, I., Semennikov, A., Senger, A., Senger, P., Shabanov, A., Shabunov, A., Shao, Ming, Sheremetiev, A. D., Shi, Shusu, Shumeiko, N., Shumikhin, V., Sibiryak, I., Sikora, B., Simakov, A., Simon, C., Simons, C., Singaraju, R. N., Singh, A. K., Singh, B. K., Singh, C. P., Singhal, V., Singla, M., Sitzmann, P., Siwek-Wilczyńska, K., Škoda, L., Skwira-Chalot, I., Som, I., Song, Guofeng, Song, Jihye, Sosin, Z., Soyk, D., Staszel, P., Strikhanov, M., Strohauer, S., Stroth, J., Sturm, C., Sultanov, R., Sun, Yongjie, Svirida, D., Svoboda, O., Szabó, A., Szczygieł, R., Talukdar, R., Tang, Zebo, Tanha, M., Tarasiuk, J., Tarassenkova, O., Târzilă, M. -G., Teklishyn, M., Tischler, T., Tlustý, P., Tölyhi, T., Toia, A., Topil'skaya, N., Träger, M., Tripathy, S., Tsakov, I., Tsyupa, Yu., Turowiecki, A., Tuturas, N. G., Uhlig, F., Usenko, E., Valin, I., Varga, D., Vassiliev, I., Vasylyev, O., Verbitskaya, E., Verhoeven, W., Veshikov, A., Visinka, R., Viyogi, Y. P., Volkov, S., Volochniuk, A., Vorobiev, A., Voronin, Aleksey, Voronin, Alexander, Vovchenko, V., Vznuzdaev, M., Wang, Dong, Wang, Xi-Wei, Wang, Yaping, Wang, Yi, Weber, M., Wendisch, C., Wessels, J. P., Wiebusch, M., Wiechula, J., Wielanek, D., Wieloch, A., Wilms, A., Winckler, N., Winter, M., Wiśniewski, K., Wolf, Gy., Won, Sanguk, Wu, Ke-Jun, Wüstenfeld, J., Xiang, Changzhou, Xu, Nu, Yang, Junfeng, Yang, Rongxing, Yin, Zhongbao, Yoo, In-Kwon, Yuldashev, B., Yushmanov, I., Zabołotny, W., Zaitsev, Yu., Zamiatin, N. I., Zanevsky, Yu., Zhalov, M., Zhang, Yifei, Zhang, Yu, Zhao, Lei, Zheng, Jiajun, Zheng, Sheng, Zhou, Daicui, Zhou, Jing, Zhu, Xianglei, Zinchenko, A., Zipper, W., Żoładź, M., Zrelov, P., Zryuev, V., Zumbruch, P., and Zyzak, M.

Subjects
Nuclear Experiment
Abstract

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter., Comment: 15 pages, 11 figures. Published in European Physical Journal A

Published
2016
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9. Challenges in QCD matter physics --The scientific programme of the Compressed Baryonic Matter experiment at FAIR

Author

Ablyazimov, T, Abuhoza, A, Adak, RP, Adamczyk, M, Agarwal, K, Aggarwal, MM, Ahammed, Z, Ahmad, F, Ahmad, N, Ahmad, S, Akindinov, A, Akishin, P, Akishina, E, Akishina, T, Akishina, V, Akram, A, Al-Turany, M, Alekseev, I, Alexandrov, E, Alexandrov, I, Amar-Youcef, S, Anđelić, M, Andreeva, O, Andrei, C, Andronic, A, Anisimov, Yu, Appelshäuser, H, Argintaru, D, Atkin, E, Avdeev, S, Averbeck, R, Azmi, MD, Baban, V, Bach, M, Badura, E, Bähr, S, Balog, T, Balzer, M, Bao, E, Baranova, N, Barczyk, T, Bartoş, D, Bashir, S, Baszczyk, M, Batenkov, O, Baublis, V, Baznat, M, Becker, J, Becker, K-H, Belogurov, S, Belyakov, D, Bendarouach, J, Berceanu, I, Bercuci, A, Berdnikov, A, Berdnikov, Y, Berendes, R, Berezin, G, Bergmann, C, Bertini, D, Bertini, O, Beşliu, C, Bezshyyko, O, Bhaduri, PP, Bhasin, A, Bhati, AK, Bhattacharjee, B, Bhattacharyya, A, Bhattacharyya, TK, Biswas, S, Blank, T, Blau, D, Blinov, V, Blume, C, Bocharov, Yu, Book, J, Breitner, T, Brüning, U, Brzychczyk, J, Bubak, A, Büsching, H, Bus, T, Butuzov, V, Bychkov, A, Byszuk, A, Cai, Xu, Cãlin, M, Cao, Ping, Caragheorgheopol, G, Carević, I, Cătănescu, V, Chakrabarti, A, Chattopadhyay, S, Chaus, A, Chen, Hongfang, Chen, LuYao, Cheng, Jianping, Chepurnov, V, Cherif, H, and Chernogorov, A

Subjects
nucl-ex, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics
Abstract

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sNN= 2.7--4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (μB> 500 MeV), effects of chiral symmetry, and the equation of state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2024, in the context of the worldwide efforts to explore high-density QCD matter.

Published
2017

10. Unravelling the clinical heterogeneity of undefined recurrent fever over time in the European registries on Autoinflammation

Author

Arts-assistenten Kinderen, Child Health, Vyzhga, Y., Wittkowski, H., Hentgen, V., Georgin-Lavialle, S., Theodoropoulou, A., Fuehner, S., Jesenak, M., Frenkel, J., Papadopoulou-Alataki, E., Anton, Jordi, Olivieri, A. Nunzia, Brunner, J., Sanchez, J., Koné-Paut, I., Fingerhutova, S., Pillet, P., Meinzer, U., Khubchandani, R., Jansson, A., Haas, J. P., Berendes, R., Kallinich, T., Horneff, G., Lilienthal, E., Papa, R., Foell, D., Lainka, E., Caorsi, R., Gattorno, M., Hofer, M., Arts-assistenten Kinderen, Child Health, Vyzhga, Y., Wittkowski, H., Hentgen, V., Georgin-Lavialle, S., Theodoropoulou, A., Fuehner, S., Jesenak, M., Frenkel, J., Papadopoulou-Alataki, E., Anton, Jordi, Olivieri, A. Nunzia, Brunner, J., Sanchez, J., Koné-Paut, I., Fingerhutova, S., Pillet, P., Meinzer, U., Khubchandani, R., Jansson, A., Haas, J. P., Berendes, R., Kallinich, T., Horneff, G., Lilienthal, E., Papa, R., Foell, D., Lainka, E., Caorsi, R., Gattorno, M., and Hofer, M.

Published
2024

11. Next generation KATRIN high precision voltage divider for voltages up to 65kV

Author

Bauer, S., Berendes, R., Hochschulz, F., Ortjohann, H. -W., Rosendahl, S., Thümmler, T., Schmidt, M., and Weinheimer, C.

Subjects
Physics - Instrumentation and Detectors
Abstract

The KATRIN (KArlsruhe TRItium Neutrino) experiment aims to determine the mass of the electron antineutrino with a sensitivity of 200meV by precisely measuring the electron spectrum of the tritium beta decay. This will be done by the use of a retarding spectrometer of the MAC-E-Filter type. To achieve the desired sensitivity the stability of the retarding potential of -18.6kV has to be monitored with a precision of 3ppm over at least two months. Since this is not feasible with commercial devices, two ppm-class high voltage dividers were developed, following the concept of the standard divider for DC voltages of up to 100kV of the Physikalisch-Technische Bundesanstalt (PTB). In order to reach such high accuracies different effects have to be considered. The two most important ones are the temperature dependence of resistance and leakage currents, caused by insulators or corona discharges. For the second divider improvements were made concerning the high-precision resistors and the thermal design of the divider. The improved resistors are the result of a cooperation with the manufacturer. The design improvements, the investigation and the selection of the resistors, the built-in ripple probe and the calibrations at PTB will be reported here. The latter demonstrated a stability of about 0.1ppm/month over a period of two years.

Published
2013
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12. APDs as Single-Photon Detectors for Visible and Near-Infrared Wavelenghts down to Hz Rates

Author

Jöhren, R., Berendes, R., Buglak, W., Hampf, D., Hannen, V., Mader, J., Nörtershäuser, W., Sánchez, R., and Weinheimer, C.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

For the SPECTRAP experiment at GSI, Germany, detectors with Single-Photon counting capability in the visible and near-infrared regime are required. For the wavelength region up to 1100 nm we investigate the performance of 2x2 mm^2 avalanche photo diodes (APDs) of type S0223 manufactured by Radiation Monitoring Devices. To minimize thermal noise, the APDs are cooled to approximately -170 deg. C using liquid nitrogen. By operating the diodes close to the breakdown voltage it is possible to achieve relative gains in excess of 2x10^4. Custom-made low noise preamplifiers are used to read out the devices. The measurements presented in this paper have been obtained at a relative gain of 2.2x10^4. At a discriminator threshold of 6 mV the resulting dark count rate is in the region of 230/s. With these settings the studied APDs are able to detect single photons at 628 nm wavelength with a photo detection efficiency of (67+-7)%. Measurements at 1020 nm wavelength have been performed using the attenuated output of a grating spectrograph with a light bulb as photon source. With this setup the photo detection efficiency at 1020 nm has been determined to be (13+-3)%, again at a threshold of 6 mV., Comment: 14 pages, 9 figures, submitted to Journal of Instrumentation

Published
2011
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14. Prävalenz und Korrelate von Angst- und Depressionssymptomen bei Jugendlichen und jungen Erwachsenen mit juveniler idiopathischer Arthritis (JIA): Ergebnisse aus COACH

Author

Milatz, F, Niewerth, M, Tomuscheit, J, Sengler, C, Grösch, N, Klotsche, J, Windschall, D, Kallinich, T, Dressler, F, Trauzeddel, R, Holl, RW, Foeldvari, I, Brück, N, Temming, S, Hospach, A, Warschburger, P, Berendes, R, Kümmerle-Deschner, J, Weller-Heinemann, F, Haas, JP, Müller-Stierlin, AS, Mutter, A, Meissner, T, Baumeister, H, Minden, K, Milatz, F, Niewerth, M, Tomuscheit, J, Sengler, C, Grösch, N, Klotsche, J, Windschall, D, Kallinich, T, Dressler, F, Trauzeddel, R, Holl, RW, Foeldvari, I, Brück, N, Temming, S, Hospach, A, Warschburger, P, Berendes, R, Kümmerle-Deschner, J, Weller-Heinemann, F, Haas, JP, Müller-Stierlin, AS, Mutter, A, Meissner, T, Baumeister, H, and Minden, K

Published
2023

16. Depressive und ängstliche Symptome bei Patienten mit juveniler idiopathischer Arthritis (JIA) - Daten aus der Inzeptionskohorte neu diagnostizierter Kinder und Jugendlicher mit JIA (ICON)

Author

Sengler, C, Oommen, P, Klotsche, J, Berendes, R, Dressler, F, Foeldvari, I, Föll, D, Geikowski, T, Haller, M, Horneff, G, Hospach, A, Kallinich, T, Kümmerle-Deschner, J, Liedmann, I, Mönkemöller, K, Niewerth, M, Rühlmann, M, Schmalbach, T, Siemer, C, Weller-Heinemann, F, Windschall, D, Minden, K, Sengler, C, Oommen, P, Klotsche, J, Berendes, R, Dressler, F, Foeldvari, I, Föll, D, Geikowski, T, Haller, M, Horneff, G, Hospach, A, Kallinich, T, Kümmerle-Deschner, J, Liedmann, I, Mönkemöller, K, Niewerth, M, Rühlmann, M, Schmalbach, T, Siemer, C, Weller-Heinemann, F, Windschall, D, and Minden, K

Published
2022

17. Development of an optimal ultrasound image acquisition protocol for pediatric knee arthritis - an international multicenter study by the imaging working groups of the PReS and GKJR

Author

Windschall, D, Trauzeddel, R, Gohar, F, Schua, S, Hardt, S, Krumrey-Langkammmerer, M, Fotis, L, Berendes, R, Haller, M, Dundar, H, Magni-Manzoni, S, Windschall, D, Trauzeddel, R, Gohar, F, Schua, S, Hardt, S, Krumrey-Langkammmerer, M, Fotis, L, Berendes, R, Haller, M, Dundar, H, and Magni-Manzoni, S

Published
2022

18. Gesundheitsbezogene Transitionskompetenz bei Jugendlichen und jungen Erwachsenen mit juveniler idiopathischer Arthritis (JIA)

Author

Niewerth, M, Minden, K, Schalm, S, Foeldvari, I, Dollinger, S, Horneff, G, Windschall, D, Kallinich, T, Dressler, F, Weller-Heinemann, F, Berendes, R, Hospach, T, Hufnagel, M, Haller, M, Hansmann, S, Klotsche, J, Niewerth, M, Minden, K, Schalm, S, Foeldvari, I, Dollinger, S, Horneff, G, Windschall, D, Kallinich, T, Dressler, F, Weller-Heinemann, F, Berendes, R, Hospach, T, Hufnagel, M, Haller, M, Hansmann, S, and Klotsche, J

Published
2022

19. TRANSITION COMPETENCE IN YOUNG PEOPLE WITH JUVENILE IDIOPATHIC ARTHRITIS HAS IMPROVED OVER TIME

Author

Minden, K., Niewerth, M., Schalm, S., Foeldvari, I., Haas, J. P., Horneff, G., Windschall, D., Kallinich, T., Dressler, F., Weller-Heinemann, F., Berendes, R., Hospach, T., Hufnagel, M., Haller, M., Hansmann, S., Klotsche, J., Minden, K., Niewerth, M., Schalm, S., Foeldvari, I., Haas, J. P., Horneff, G., Windschall, D., Kallinich, T., Dressler, F., Weller-Heinemann, F., Berendes, R., Hospach, T., Hufnagel, M., Haller, M., Hansmann, S., and Klotsche, J.

Published
2022

20. EFFECTIVENESS AND SAFETY OF IL-6 INHIBITION (TOCILIZUMAB) VERSUS TUMOUR NECROSIS FACTOR INHIBITION IN POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS: RESULTS FROM THE OBSERVATIONAL BIKER STUDY

Author

Klein, A., Zimmer, A., Hospach, T., Weller-Heinemann, F., Hansmann, S., Kuemmerle-Deschner, J., Fasshauer, M., Minden, K., Foeldvari, I., Rietschel, C., Windschall, D., Trauzeddel, R., Hufnagel, M., Foell, D., Berendes, R., Boeschow, G., Oommen, P., Dressler, F., Horneff, G., Klein, A., Zimmer, A., Hospach, T., Weller-Heinemann, F., Hansmann, S., Kuemmerle-Deschner, J., Fasshauer, M., Minden, K., Foeldvari, I., Rietschel, C., Windschall, D., Trauzeddel, R., Hufnagel, M., Foell, D., Berendes, R., Boeschow, G., Oommen, P., Dressler, F., and Horneff, G.

Published
2022

21. POS0338 TRANSITION COMPETENCE IN YOUNG PEOPLE WITH JUVENILE IDIOPATHIC ARTHRITIS HAS IMPROVED OVER TIME

Author

Minden, K., primary, Niewerth, M., additional, Schalm, S., additional, Foeldvari, I., additional, Haas, J. P., additional, Horneff, G., additional, Windschall, D., additional, Kallinich, T., additional, Dressler, F., additional, Weller-Heinemann, F., additional, Berendes, R., additional, Hospach, T., additional, Hufnagel, M., additional, Haller, M., additional, Hansmann, S., additional, and Klotsche, J., additional

Published
2022
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22. OP0217 EFFECTIVENESS AND SAFETY OF IL-6 INHIBITION (TOCILIZUMAB) VERSUS TUMOUR NECROSIS FACTOR INHIBITION IN POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS: RESULTS FROM THE OBSERVATIONAL BIKER STUDY

Author

Klein, A., primary, Zimmer, A., additional, Hospach, T., additional, Weller-Heinemann, F., additional, Hansmann, S., additional, Kuemmerle-Deschner, J., additional, Fasshauer, M., additional, Minden, K., additional, Foeldvari, I., additional, Rietschel, C., additional, Windschall, D., additional, Trauzeddel, R., additional, Hufnagel, M., additional, Foell, D., additional, Berendes, R., additional, Boeschow, G., additional, Oommen, P., additional, Dressler, F., additional, and Horneff, G., additional

Published
2022
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24. SARS-CoV-2-Infektionen bei Kindern und Jugendlichen mit rheumatischen Erkrankungen – Daten aus der Kinder-Kerndokumentation

Author

Sengler, C, Eulert, S, Minden, K, Niewerth, M, Horneff, G, Kümmerle-Deschner, J, Siemer, C, Berendes, R, Girschick, HJ, Hühn, R, Borte, M, Hospach, A, Emminger, W, Armann, J, Klein, A, and Kallinich, T

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Obwohl Kinder und Jugendliche seltener und milder an COVID-19 erkranken als Erwachsene, ist unklar, welchen Einfluss die SARS-CoV-2-Infektion auf juvenile Patienten mit rheumatischen Erkrankungen hat. Aufgrund ihrer Grunderkrankung sowie der therapeutischen Immunsuppression besteht möglicherweise[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2021
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25. INSAID Variant Classification and Eurofever Criteria Guide Optimal Treatment Strategy in Patients with TRAPS: Data from the Eurofever Registry

Author

Papa R, Lane T, Minden K, Touitou I, Cantarini L, Cattalini M, Obici L, Jansson AF, Belot A, Frenkel J, Anton-Lopez J, Wolska-Kusnierz B, Berendes R, Remesal A, Jelusic M, Hoppenreijs E, Espada G, Nikishina I, Maggio MC, Bovis F, Masini M, Youngstein T, Rezk T, Papadopoulou C, Brogan PA, Hawkins PN, Woo P, Ruperto N, Gattorno M, Lachmann HJ, and Pediatric Rheumatology International Trials Organization (PRINTO), the EUROTRAPS

Subjects
Colchicine, Autoinflammatory diseases, AA amyloidosis, TRAPS, Anakinra
Abstract

BACKGROUND: TNF receptor-associated periodic syndrome (TRAPS) is a rare autoinflammatory disease caused by dominant mutation of the TNF super family receptor 1A (TNFRSF1A) gene. Data regarding long-term treatment outcomes are lacking. OBJECTIVE: To assess correlations of genotype-phenotypes in patients with TRAPS, as defined by the International Study Group for Systemic Autoinflammatory Diseases (INSAID) classification and Eurofever criteria, with treatment responses. METHODS: Data from 226 patients with variants of the TNFRSF1A gene and enrolled in the Eurofever registry were classified according to the INSAID classification in groups A (pathogenic or likely pathogenic variants), B (variants of uncertain significance or not classified variants), and C (benign or likely benign variants) and screened for Eurofever criteria. RESULTS: In group A (127 of 226 patients, 56%), all fulfilled Eurofever criteria and 20 of 127 patients (16%) developed AA amyloidosis. In group B (78 of 226 patients, 35%), 40 of 78 patients (51%) did not fulfill Eurofever criteria, displaying a lower incidence of abdominal pain (P < .02) and higher efficacy rate of on-demand nonsteroidal anti-inflammatory drugs (P 85% complete response). No patients on anti-IL-1 treatments developed AA amyloidosis, and 7 women with a history of failure to conceive had successful pregnancies. CONCLUSION: Anti-IL-1 drugs are the best maintenance treatment in patients with TRAPS. The diagnosis of TRAPS should be considered very carefully in patients of group B not fulfilling Eurofever criteria and group C, and colchicine may be preferable as the first maintenance treatment.

Published
2021

26. INSAID Variant Classification and Eurofever Criteria Guide Optimal Treatment Strategy in Patients with TRAPS: Data from the Eurofever Registry

Author

Papa, R., Lane, T., Minden, K., Touitou, I., Cantarini, L., Cattalini, M., Obici, L., Jansson, A.F., Belot, A., Frenkel, J., Anton, J., Wolska-Kusnierz, B., Berendes, R., Remesal, A., Jelusic, M., Hoppenreijs, E.P., Espada, G., Nikishina, I., Maggio, M.C., Bovis, F., Masini, M., Youngstein, T., Rezk, T., Papadopoulou, C., Brogan, P.A., Hawkins, P.N., Woo, P., Ruperto, N., Gattorno, M., Lachmann, H.J., Papa, R., Lane, T., Minden, K., Touitou, I., Cantarini, L., Cattalini, M., Obici, L., Jansson, A.F., Belot, A., Frenkel, J., Anton, J., Wolska-Kusnierz, B., Berendes, R., Remesal, A., Jelusic, M., Hoppenreijs, E.P., Espada, G., Nikishina, I., Maggio, M.C., Bovis, F., Masini, M., Youngstein, T., Rezk, T., Papadopoulou, C., Brogan, P.A., Hawkins, P.N., Woo, P., Ruperto, N., Gattorno, M., and Lachmann, H.J.

Abstract

Item does not contain fulltext, BACKGROUND: TNF receptor-associated periodic syndrome (TRAPS) is a rare autoinflammatory disease caused by dominant mutation of the TNF super family receptor 1A (TNFRSF1A) gene. Data regarding long-term treatment outcomes are lacking. OBJECTIVE: To assess correlations of genotype-phenotypes in patients with TRAPS, as defined by the International Study Group for Systemic Autoinflammatory Diseases (INSAID) classification and Eurofever criteria, with treatment responses. METHODS: Data from 226 patients with variants of the TNFRSF1A gene and enrolled in the Eurofever registry were classified according to the INSAID classification in groups A (pathogenic or likely pathogenic variants), B (variants of uncertain significance or not classified variants), and C (benign or likely benign variants) and screened for Eurofever criteria. RESULTS: In group A (127 of 226 patients, 56%), all fulfilled Eurofever criteria and 20 of 127 patients (16%) developed AA amyloidosis. In group B (78 of 226 patients, 35%), 40 of 78 patients (51%) did not fulfill Eurofever criteria, displaying a lower incidence of abdominal pain (P < .02) and higher efficacy rate of on-demand nonsteroidal anti-inflammatory drugs (P < .02) and colchicine (P < .001). Group C (21 of 226 patients, 9%) presented a milder disease (P < .02) and none fulfilled Eurofever criteria. Anti-IL-1 drugs were the most frequently used in patients fulfilling Eurofever criteria, with the highest efficacy rate (>85% complete response). No patients on anti-IL-1 treatments developed AA amyloidosis, and 7 women with a history of failure to conceive had successful pregnancies. CONCLUSION: Anti-IL-1 drugs are the best maintenance treatment in patients with TRAPS. The diagnosis of TRAPS should be considered very carefully in patients of group B not fulfilling Eurofever criteria and group C, and colchicine may be preferable as the first maintenance treatment.

Published
2021

27. PREVALENCE AND CORRELATES OF UNDERWEIGHT, OVERWEIGHT AND OBESITY AMONG PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS (JIA): EVIDENCE FROM THE NATIONAL PAEDIATRIC RHEUMATOLOGIC DATABASE (NPRD)

Author

Milatz, F., Klotsche, J., Niewerth, M., Hoerstermann, J., Windschall, D., Weller-Heinemann, F., Dressler, F., Berendes, R., Haas, J. P., Horneff, G., Minden, K., Milatz, F., Klotsche, J., Niewerth, M., Hoerstermann, J., Windschall, D., Weller-Heinemann, F., Dressler, F., Berendes, R., Haas, J. P., Horneff, G., and Minden, K.

Published
2021

28. The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry

Author

Lachmann, H J, Papa, R, Gerhold, K, Obici, L, Touitou, I, Cantarini, L, Frenkel, J, Anton, J, Kone-Paut, I, Cattalini, M, Bader-Meunier, B, Insalaco, A, Hentgen, V, Merino, R, Modesto, C, Toplak, N, Berendes, R, Ozen, S, Cimaz, R, Jansson, A, Brogan, P A, Hawkins, P N, Ruperto, N, Martini, A, Woo, P, and Gattorno, M

Published
2014
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29. POS1309 PREVALENCE AND CORRELATES OF UNDERWEIGHT, OVERWEIGHT AND OBESITY AMONG PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS (JIA): EVIDENCE FROM THE NATIONAL PAEDIATRIC RHEUMATOLOGIC DATABASE (NPRD)

Author

Milatz, F., primary, Klotsche, J., additional, Niewerth, M., additional, Hörstermann, J., additional, Windschall, D., additional, Weller-Heinemann, F., additional, Dressler, F., additional, Berendes, R., additional, Haas, J. P., additional, Horneff, G., additional, and Minden, K., additional

Published
2021
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30. POS1202 EXPERIENCE WITH COVID-19 IN GERMAN PAEDIATRIC RHEUMATOLOGY CENTRES

Author

Klein, A., primary, Windschall, D., additional, Emminger, W., additional, Berendes, R., additional, Kuemmerle-Deschner, J., additional, Trauzeddel, R., additional, Rietschel, C., additional, Kühn, A., additional, Hufnagel, M., additional, Sailer-Hoeck, M., additional, Hospach, T., additional, Haller, M., additional, Mrusek, S., additional, Sengler, C., additional, Minden, K., additional, and Horneff, G., additional

Published
2021
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31. CBM Collaboration

Author

Ablyazimov, T., primary, Adak, R.P., additional, Adler, A., additional, Agarwal, A., additional, Agarwal, K., additional, Ahammed, Z., additional, Ahmad, A., additional, Ahmad, F., additional, Ahmad, N., additional, Akindinov, A., additional, Akishin, P., additional, Akishina, V., additional, Al-Turany, M., additional, Alekseev, I., additional, Alexandrov, E., additional, Alexandrov, I., additional, Andronic, A., additional, Appelshäuser, H., additional, Argintaru, D., additional, Arnoldi-Meadows, B., additional, Atkin, E., additional, Azmi, M.D., additional, Baban, V., additional, Bähr, S., additional, Bajdel, M., additional, Balassa, G., additional, Balzer, M., additional, Baranova, N., additional, Bashir, S., additional, Baszczyk, M., additional, Bechtel, E., additional, Becker, J., additional, Becker, K.-H., additional, Becker, M., additional, Beckhoff, J., additional, Belogurov, S., additional, Belousov, A., additional, Bendarouach, J., additional, Bercuci, A., additional, Berendes, R., additional, Bertini, D., additional, Bertini, O., additional, Bezshyyko, O., additional, Bhaduri, P.P., additional, Bhasin, A., additional, Bhat, S.A., additional, Bhat, W.A., additional, Bhattacharjee, B., additional, Bhattacharyya, A., additional, Bhattacharyya, T.K., additional, Biswas, S., additional, Blank, T., additional, Blau, D., additional, Blume, C., additional, Brzychczyk, J., additional, Bus, T., additional, Bychkov, A., additional, Cãlin, M., additional, Caselle, M., additional, Chakrabarti, A., additional, Chatterjee, S., additional, Chattopadhyay, S., additional, Chaus, A., additional, Cherif, H., additional, Chudoba, P., additional, Clerkin, E., additional, Csanád, M., additional, Dahm, P., additional, Das, Supriya, additional, Susovan, Das, additional, de Cuveland, J., additional, Demanov, A., additional, Dementiev, D., additional, Deng, Wendi, additional, Deng, Zhi, additional, Deppe, H., additional, Deppner, I., additional, Derenovskaya, O., additional, Deveaux, M., additional, Ding, Zhiguo, additional, Dong, Sheng, additional, Dorenskaya, E., additional, Dorosz, P., additional, Dubey, A.K., additional, Dubla, A., additional, Dürr, M., additional, Elsha, V.V., additional, Emschermann, D., additional, Engel, H., additional, Eşanu, T., additional, Eschke, J., additional, Esen, M., additional, Fan, Xingming, additional, Fateev, O., additional, Feier-Riesen, C., additional, Feng, Sheng-Qin, additional, Fidorra, F., additional, Figuli, S.P.D., additional, Finogeev, D., additional, Fischer, P., additional, Flemming, H., additional, Förtsch, J., additional, Foka, P., additional, Frankenfeld, U., additional, Friese, V., additional, Friske, E., additional, Fröhlich, I., additional, Frühauf, J., additional, Galatyuk, T., additional, Ganai, R., additional, Gangopadhyay, G., additional, Gao, Xin, additional, Gasik, P., additional, Geßler, T., additional, Ghosh, C., additional, Ghosh, S.K., additional, Giang, D., additional, Gläßel, S., additional, Golinka-Bezshyyko, L., additional, Golosov, O., additional, Golovnya, S., additional, Golubeva, M., additional, Golubkov, D., additional, Gope, S., additional, Gorbunov, S., additional, Gorokhov, S., additional, Gottschalk, D., additional, Gryboś, P., additional, Guber, F., additional, Gumiński, M., additional, Gupta, A., additional, Gusakov, Yu., additional, Haas, R., additional, Han, Dong, additional, Hartmann, H., additional, He, Shu, additional, Hehner, J., additional, Heine, N., additional, Herrmann, N., additional, Heuser, J.M., additional, Höhne, C., additional, Holzmann, R., additional, Hu, Dongdong, additional, Huang, Guangming, additional, Huang, Xinjie, additional, Hutter, D., additional, Irfan, M., additional, Ivanishchev, D., additional, Ivanov, P., additional, Ivanov, Victor, additional, Ivanov, Vladimir, additional, Ivashkin, A., additional, Izvestnyy, A., additional, Jahan, H., additional, Janson, T., additional, Jash, A., additional, Jipa, A., additional, Kadenko, I., additional, Kähler, P., additional, Kämpfer, B., additional, Kampert, K.-H., additional, Kapell, R., additional, Karabowicz, R., additional, Kargin, N., additional, Karmanov, D., additional, Karpushkin, N., additional, Kashirin, E., additional, Kashyap, V.K.S., additional, Kasiński, K., additional, Kasprowicz, G., additional, Kazantsev, A., additional, Kebschull, U., additional, Kekelidze, G., additional, Khan, M.M., additional, Khan, S., additional, Khanzadeev, A., additional, Khasanov, F., additional, Kiryakov, A., additional, Kiš, M., additional, Kisel, I., additional, Kisel, P., additional, Kiselev, S., additional, Kiss, T., additional, Klaus, P., additional, Kłeczek, R., additional, Klein-Bösing, Ch., additional, Klochkov, V., additional, Kmon, P., additional, Koch, K., additional, Kochenda, L., additional, Koczoń, P., additional, Kohn, M., additional, Kolb, R., additional, Kolozhvari, A., additional, Komkov, B., additional, Korolev, M., additional, Korolko, I., additional, Kot, O., additional, Kotte, R., additional, Kovalchuk, O., additional, Koziel, M., additional, Kozlov, G., additional, Kozlov, V., additional, Kravtsov, P., additional, Kres, I., additional, Kresan, D., additional, Kruszewski, M., additional, Kryanev, A.V., additional, Kryshen, E., additional, Krzyżanowska, A., additional, Kucewicz, W., additional, Kudin, L., additional, Kudryashov, I., additional, Kugler, A., additional, Kuhl, P., additional, Kumar, Ajay, additional, Kumar, Ajit, additional, Kumar, L., additional, Kundu, S.K., additional, Kurepin, A., additional, Kurepin, N., additional, Kurilkin, P., additional, Kuznetsov, S., additional, Kyva, V., additional, Ladygin, V., additional, Lara, C., additional, Lavrik, E., additional, Lazanu, I., additional, Lebedev, A., additional, Lebedev, S., additional, Lebedeva, E., additional, Lehnert, J., additional, Leifels, Y., additional, Li, Chao, additional, Li, Yuanjing, additional, Lindenstruth, V., additional, Liu, Feng, additional, Lobanov, I., additional, Lobanova, E., additional, Löchner, S., additional, Loizeau, P.-A., additional, Łojek, K., additional, Lubynets, O., additional, Lucio Martínez, J.A., additional, Luo, Xiaofeng, additional, Lymanets, A., additional, Lyu, Pengfei, additional, Lyublev, N., additional, Ma, Jian-Hao, additional, Maevskaya, A., additional, Mahajan, S., additional, Maj, P., additional, Majka, Z., additional, Malakhov, A., additional, Malankin, E., additional, Malkevich, D., additional, Mallick, B., additional, Malyatina, O., additional, Mandal, M., additional, Manko, V., additional, Maragoto Rodriguez, O., additional, Marin Garcia, A.M., additional, Markert, J., additional, Matulewicz, T., additional, Mehta, S., additional, Merkin, M., additional, Meyer-Ahrens, A., additional, Michel, J., additional, Miedzik, P., additional, Mik, L., additional, Mikhailov, K., additional, Mikhaylov, V., additional, Militsija, V., additional, Mir, M.F., additional, Miskowiec, D., additional, Mohanty, B., additional, Momot, I., additional, Morgenweck, H., additional, Morhardt, T., additional, Morozov, S., additional, Mühlheim, D., additional, Müller, W.F.J., additional, Müntz, C., additional, Mukherjee, S., additional, Munkes, P., additional, Murin, Yu., additional, Nandy, E., additional, Naumann, L., additional, Nayak, T., additional, Nickels, F., additional, Niebur, W., additional, Nikulin, V., additional, Normanov, D., additional, Olar, A., additional, Otfinowski, P., additional, Otto, J.H., additional, Ovcharenko, E., additional, Pan, Liang-ming, additional, Panasenko, I., additional, Pandey, S., additional, Parfenov, P., additional, Parzhitskiy, S., additional, Patel, V., additional, Pauly, C., additional, Petráček, V., additional, Petri, M., additional, Petriş, M., additional, Petrovici, M., additional, Petukhov, O., additional, Pfeifer, D., additional, Pfistner, P., additional, Piasecki, K., additional, Pietraszko, J., additional, Pitsch, G., additional, Płaneta, R., additional, Plotnikov, V., additional, Plujko, V., additional, Pluta, J., additional, Poźniak, K., additional, Prasad, S.K., additional, Prokudin, M., additional, Prozorov, A., additional, Pugach, M., additional, Pugatch, V., additional, Puntke, A., additional, Querchfeld, S., additional, Radulescu, L., additional, Raha, S., additional, Raisig, P., additional, Raja, W., additional, Ramazanov, D., additional, Rautenberg, J., additional, Ray, R., additional, Redelbach, A., additional, Rehman, T., additional, Reinefeld, A., additional, Reshetin, A., additional, Ristea, C., additional, Ristea, O., additional, Rodriguez Rodriguez, A., additional, Roether, F., additional, Romaniuk, R., additional, Rost, A., additional, Rostchin, E., additional, Roy, A., additional, Roy, D., additional, Roy, S., additional, Rubio, E., additional, Rustamov, A., additional, Ryabov, Yu., additional, Sahoo, R., additional, Sahu, P.K., additional, Sahu, S.K., additional, Saini, J., additional, Salem, F., additional, Samanta, S., additional, Sambyal, S.S., additional, Samsonov, V., additional, Sander, O., additional, Sarangi, S., additional, Sau, S., additional, Schiaua, C., additional, Schintke, F., additional, Schmidt, C.J., additional, Schmidt, D., additional, Schmidt, H.R., additional, Schneider, P.M., additional, Schütt, T., additional, Seck, F., additional, Segal, I., additional, Selyuzhenkov, I., additional, Semennikov, A., additional, Sen, A., additional, Senger, A., additional, Senger, P., additional, Shabanov, A., additional, Shabunov, A., additional, Sharma, N., additional, Sheremetiev, A.D., additional, Shi, Shusu, additional, Shirinkin, S., additional, Shiroya, M., additional, Shitenkow, M., additional, Shumikhin, V., additional, Sibiryak, I., additional, Sidorenko, V., additional, Simon, C., additional, Simons, C., additional, Singh, A.K., additional, Singh, B.K., additional, Singh, C.P., additional, Singh, O., additional, Singh, R., additional, Singhal, V., additional, Škoda, L., additional, Smith, D., additional, Söhngen, Y., additional, Som, I., additional, Spicker, D., additional, Stach, D., additional, Staszel, P., additional, Storozhyk, D., additional, Strikhanov, M., additional, Stroth, J., additional, Stüllein, C., additional, Sturm, C., additional, Su, Yuan, additional, Sukhov, N., additional, Sultanov, R., additional, Sun, Yongjie, additional, Sun, Zhengyang, additional, Svirida, D., additional, Szczygieł, R., additional, Taranenko, A., additional, Tarassenkova, O., additional, Tölyhi, T., additional, Toia, A., additional, Topil'skaya, N., additional, Träger, M., additional, Traxler, M., additional, Trifonova, E., additional, Tsyupa, Yu., additional, Tuturas, N.G., additional, Uhlig, F., additional, Unger, K.L., additional, Usenko, E., additional, Varga, D., additional, Vassiliev, I., additional, Vasylyev, O., additional, Visinka, R., additional, Völkl, M., additional, Volkova, E., additional, Vorobiev, A., additional, Voronin, A., additional, Wahmes, L., additional, Wang, Botan, additional, Wang, Dong, additional, Wang, Tianxing, additional, Wang, Xinjian, additional, Wang, Yi, additional, Weber, A.A., additional, Weber, M., additional, Weidenkaff, P., additional, Weiglhofer, F., additional, Wessels, J.P., additional, Wielanek, D., additional, Wieloch, A., additional, Wilms, A., additional, Wójcik, D., additional, Wolf, Gy., additional, Wu, Ke-Jun, additional, Wu, Qiqi, additional, Yang, Junfeng, additional, Yang, Rongxing, additional, Yin, Zhongbao, additional, Yoo, In-Kwon, additional, Yuan, Jianhui, additional, Yushmanov, I., additional, Zabołotny, W., additional, Zaitsev, Yu., additional, Zamiatin, N.I., additional, Zbroszczyk, H., additional, Zhalov, M., additional, Zhang, Qiunan, additional, Zhang, Xiaoming, additional, Zhang, Yu, additional, Zhao, Yan-Qing, additional, Zheng, Sheng, additional, Zhou, Daicui, additional, Zhou, Jian, additional, Zhou, Wenxiong, additional, Zhu, Xianglei, additional, Zinchenko, A., additional, Zivko, I., additional, Żoładź, M., additional, Zorn, F., additional, Zubrzycka, W., additional, Zumbruch, P., additional, and Zyzak, M., additional

Published
2021
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32. SAT0490 MATCHED CONTROLLED SURVEILLANCE OF TOCILIZUMAB TREATMENT FOR POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS–AN INTERIM ANALYSIS

Author

Klein, A., primary, Hospach, T., additional, Weller-Heinemann, F., additional, Hansmann, S., additional, Kuemmerle-Deschner, J., additional, Fasshauer, M., additional, Minden, K., additional, Foeldvari, I., additional, Rietschel, C., additional, Schwarz, T., additional, Trauzeddel, R., additional, Hufnagel, M., additional, Foell, D., additional, Berendes, R., additional, Boeschow, G., additional, Oommen, P., additional, Dressler, F., additional, Helling-Bakki, A., additional, and Horneff, G., additional

Published
2020
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33. FRI0457 LONG-TERM OUTCOMES AND TREATMENT EFFICACY IN PATIENTS WITH TNF RECEPTOR-ASSOCIATED AUTOINFLAMMATORY SYNDROME (TRAPS) FROM THE EUROFEVER INTERNATIONAL REGISTRY

Author

Papa, R., primary, Lane, T., additional, Bovis, F., additional, Minden, K., additional, Touitou, I., additional, Cantarini, L., additional, Cattalini, M., additional, Obici, L., additional, Jansson, A., additional, Belot, A., additional, Woska-Kuśnierz, B., additional, Berendes, R., additional, Remesal, A., additional, Jelusic, M., additional, Espada, G., additional, Nikishina, I., additional, Hoppenreijs, E., additional, Maggio, M. C., additional, Youngstein, T., additional, Rezk, T., additional, Papadopoulou, C., additional, Brogan, P., additional, Hawkins, P. N., additional, Woo, P., additional, Ruperto, N., additional, Gattorno, M., additional, and Lachmann, H. J., additional

Published
2020
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35. Tocilizumab-Behandlung im Vergleich zur Behandlung mit TNF-Inhibitoren bei polyartikulärer juveniler idiopathischer Arthritis mit - Daten aus dem BIKER Register

Author

Klein, A, Minden, K, Hufnagel, M, Trauzeddel, R, Ganser, G, Weller-Heinemann, F, Rietschel, C, Hospach, A, Foeldvari, I, Kümmerle-Deschner, J, Föll, D, Hansmann, S, Conzelmann, D, Borte, M, Oommen, PT, Thon, A, Böschow, G, Berendes, R, Horneff, G, Klein, A, Minden, K, Hufnagel, M, Trauzeddel, R, Ganser, G, Weller-Heinemann, F, Rietschel, C, Hospach, A, Foeldvari, I, Kümmerle-Deschner, J, Föll, D, Hansmann, S, Conzelmann, D, Borte, M, Oommen, PT, Thon, A, Böschow, G, Berendes, R, and Horneff, G

Published
2019

38. Reduction of stored-particle background by a magnetic pulse method at the KATRIN experiment

Author

Bauer , S., Beck , M., Beglarian , A., Behrens , J., Berendes , R., Bergmann , T., Berlev , A., Besserer , U., Blaum , K., Bode , T., Bornschein , B., Bornschein , L., Brunst , T., Buglak , W., Buzinsky , N., Chilingaryan , S., Choi , W.Q., Deffert , M., Doe , P.J., Dragoun , O., Drexlin , G., Dyba , S., Edzards , F., Eitel , K., Ellinger , E., Engel , R., Enomoto , S., Erhard , M., Eversheim , D., Fedkevych , M., Formaggio , J.A., Fränkle , F.M., Franklin , G.B., Friedel , F., Fulst , A., Furse , D., Gil , W., Glück , F., Gonzalez Ureña , A., Grohmann , S., Grössle , R., Gumbsheimer , R., Hackenjos , M., Hannen , V., Harms , F., Haußmann , N., Heizmann , F., Helbing , K., Herz , W., Hickford , S., Hilk , D., Howe , M.A., Huber , A., Jansen , A., Kellerer , J., Kernert , N., Kippenbrock , L., Kleesiek , M., Klein , M., Kopmann , A., Korzeczek , M., Kovalík , A., Krasch , B., Kraus , M., Kuckert , L., Lasserre , T., Lebeda , O., Letnev , J., Lokhov , A., Machatschek , M., Marsteller , A., Martin , E.L., Mertens , S., Mirz , S., Monreal , B., Neumann , H., Niemes , S., Off , A., Osipowicz , A., Otten , E., Parno , D.S., Pollithy , A., Poon , A.W.P., Priester , F., Ranitzsch , P.C.-O., Rest , O., Robertson , R.G.H., Roccati , F., Rodenbeck , C., Röllig , M., Röttele , C., Ryšavý , M., Sack , R., Saenz , A., Schimpf , L., Schlösser , K., Schlösser , M., Schönung , K., Schrank , M., Seitz-Moskaliuk , H., Sentkerestiová , J., Sibille , V., Slezák , M., Steidl , M., Steinbrink , N., Sturm , M., Suchopar , M., Telle , H.H., Thorne , L.A., Thümmler , T., Titov , N., Tkachev , I., Trost , N., Valerius , K., Vénos , D., Vianden , R., Vizcaya Hernández , A.P., Wandkowsky , N., Weber , M., Weinheimer , C., Weiss , C., Welte , S., Wendel , J., Wilkerson , J.F., Wolf , J., Wüstling , S., Zadoroghny , S., Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, and KATRIN

Subjects
radon: nuclide, Neutrino mass, Physics::Instrumentation and Detectors, Background reduction methods, coil, Monte Carlo methods, spectrometer, Radon background, KATRIN, numerical calculations, background: radioactivity, [ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], background: suppression
Abstract

The KATRIN experiment aims to determine the effective electron neutrino mass with a sensitivity of $0.2\,{\text{eV}/c^2}$ (90\% C.L.) by precision measurement of the shape of the tritium \textbeta-spectrum in the endpoint region. The energy analysis of the decay electrons is achieved by a MAC-E filter spectrometer. A common background source in this setup is the decay of short-lived isotopes, such as $^{219}$Rn and $^{220}$Rn, in the spectrometer volume. Active and passive countermeasures have been implemented and tested at the KATRIN main spectrometer. One of these is the magnetic pulse method, which employs the existing air coil system to reduce the magnetic guiding field in the spectrometer on a short timescale in order to remove low- and high-energy stored electrons. Here we describe the working principle of this method and present results from commissioning measurements at the main spectrometer. Simulations with the particle-tracking software Kassiopeia were carried out to gain a detailed understanding of the electron storage conditions and removal processes.

Published
2018

40. Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers

Author

Federici S., Sormani M. P., Ozen S., Lachmann H. J., Amaryan G., Woo P., Kone-Paut I., Dewarrat N., Cantarini L., Insalaco A., Uziel Y., Rigante D., Quartier P., Demirkaya E., Herlin T., Meini A., Fabio G., Kallinich T., Martino S., Butbul A. Y., Olivieri A., Kuemmerle-Deschner J., Neven B., Simon A., Ozdogan H., Touitou I., Frenkel J., Hofer M., Martini A., Ruperto N., Gattorno M., Espada G., Russo R., De Cunto C., Boros C., Borzutzky A., Jelusic-Drazic M., Dolezalova P., Nielsen S., Hentgen V., Schwarz T., Berendes R., Jansson A., Horneff G., Papadopoulou-Alataki E., Tsitsami E., Tsakalidou F. K., Gallizzi R., Obici L., Barone P., Cimaz R., Alessio M., Nishikomori R., Stanevicha V., Hoppenreijs E., Wolska-Kusnierz B., Iagaru N., Nikishina I., Al-Mayouf S. M., Sewairi, Susic G., Toplak N., Modesto C., Elorduy M. J. R., Anton J., Bou R., Federici, S., Sormani, M. P., Ozen, S., Lachmann, H. J., Amaryan, G., Woo, P., Kone-Paut, I., Dewarrat, N., Cantarini, L., Insalaco, A., Uziel, Y., Rigante, D., Quartier, P., Demirkaya, E., Herlin, T., Meini, A., Fabio, G., Kallinich, T., Martino, S., Butbul, A. Y., Olivieri, A., Kuemmerle-Deschner, J., Neven, B., Simon, A., Ozdogan, H., Touitou, I., Frenkel, J., Hofer, M., Martini, A., Ruperto, N., Gattorno, M., Espada, G., Russo, R., De Cunto, C., Boros, C., Borzutzky, A., Jelusic-Drazic, M., Dolezalova, P., Nielsen, S., Hentgen, V., Schwarz, T., Berendes, R., Jansson, A., Horneff, G., Papadopoulou-Alataki, E., Tsitsami, E., Tsakalidou, F. K., Gallizzi, R., Obici, L., Barone, P., Cimaz, R., Alessio, M., Nishikomori, R., Stanevicha, V., Hoppenreijs, E., Wolska-Kusnierz, B., Iagaru, N., Nikishina, I., Al-Mayouf, S. M., Sewairi, Susic, G., Toplak, N., Modesto, C., Elorduy, M. J. R., Anton, J., Bou, R., Istituto Giannina Gaslini, Genova, Immunologia Clinica e Sperimentale, University of Genoa (UNIGE), Hacettepe University = Hacettepe Üniversitesi, National Amyloidosis Centre, University College London Medical School, University College of London [London] (UCL), 'ARABKIR' JOINT MEDICAL CENTER & INSTITUTE OF CHILD AND ADOLESCENT HEALTH, Cardiac Unit, Institute of Child Health (UCL), Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses [CH Versailles] (CeRéMAIA - Hôpital André Mignot), Centre Hospitalier de Versailles André Mignot (CHV), University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Università degli Studi di Siena = University of Siena (UNISI), Children's Hospital Bambino Gesù IRCCS [Rome], Meir Medical Centre, Università cattolica del Sacro Cuore [Roma] (Unicatt), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Ankara University School of Medicine [Turkey], Aarhus University Hospital, Università degli Studi di Brescia [Brescia], IRCCS Istituto Nazionale dei Tumori [Milano], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Università degli studi di Torino (UNITO), Rambam Medical Health Center, Israel., Universita degli studi di Napoli 'Parthenope' [Napoli], Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Radboud University Medical Centre [Nijmegen, The Netherlands], Cerrahpasa Faculty of Medicine, Istanbul University, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), University Medical Center [Utrecht], Geneva University Hospital (HUG), Universita degli studi di Genova, and Olivieri, Alma Nunzia

Subjects
Male, Pediatrics, Multivariate analysis, [SDV]Life Sciences [q-bio], Fever Syndromes, Familial Mediterranean fever, Immunology and Allergy, Mevalonate Kinase Deficiency/classification/diagnosis, Registries, Child, ddc:618, Evidence-Based Medicine, Middle Aged, Pharyngitis, 3. Good health, Familial Mediterranean Fever, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Child, Preschool, Autoinflammation, Familial Mediterranean Fever/classification/diagnosis, Female, medicine.symptom, Periodic fever syndrome, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], Adult, medicine.medical_specialty, Fever, Adolescent, Immunology, Cryopyrin-Associated Periodic Syndromes/classification/diagnosis, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Young Adult, Inflammation, Rheumatology, medicine, Humans, Preschool, Hereditary Autoinflammatory Diseases/classification/diagnosis, Receiver operating characteristic, business.industry, Hereditary Autoinflammatory Diseases, Case-control study, Cryopyrin-associated periodic syndrome, Infant, Gold standard (test), medicine.disease, Case-Control Studies, Cryopyrin-Associated Periodic Syndromes, Mevalonate Kinase Deficiency, ROC Curve, business
Abstract

Item does not contain fulltext The objective of this work was to develop and validate a set of clinical criteria for the classification of patients affected by periodic fevers. Patients with inherited periodic fevers (familial Mediterranean fever (FMF); mevalonate kinase deficiency (MKD); tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS); cryopyrin-associated periodic syndromes (CAPS)) enrolled in the Eurofever Registry up until March 2013 were evaluated. Patients with periodic fever, aphthosis, pharyngitis and adenitis (PFAPA) syndrome were used as negative controls. For each genetic disease, patients were considered to be 'gold standard' on the basis of the presence of a confirmatory genetic analysis. Clinical criteria were formulated on the basis of univariate and multivariate analysis in an initial group of patients (training set) and validated in an independent set of patients (validation set). A total of 1215 consecutive patients with periodic fevers were identified, and 518 gold standard patients (291 FMF, 74 MKD, 86 TRAPS, 67 CAPS) and 199 patients with PFAPA as disease controls were evaluated. The univariate and multivariate analyses identified a number of clinical variables that correlated independently with each disease, and four provisional classification scores were created. Cut-off values of the classification scores were chosen using receiver operating characteristic curve analysis as those giving the highest sensitivity and specificity. The classification scores were then tested in an independent set of patients (validation set) with an area under the curve of 0.98 for FMF, 0.95 for TRAPS, 0.96 for MKD, and 0.99 for CAPS. In conclusion, evidence-based provisional clinical criteria with high sensitivity and specificity for the clinical classification of patients with inherited periodic fevers have been developed.

Published
2015
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42. Technical design and commissioning of the KATRIN large-volume air coil system

Author

Erhard, M., primary, Behrens, J., additional, Bauer, S., additional, Beglarian, A., additional, Berendes, R., additional, Drexlin, G., additional, Glück, F., additional, Gumbsheimer, R., additional, Hergenhan, J., additional, Leiber, B., additional, Mertens, S., additional, Osipowicz, A., additional, Plischke, P., additional, Reich, J., additional, Thümmler, T., additional, Wandkowsky, N., additional, Weinheimer, C., additional, and Wüstling, S., additional

Published
2018
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43. The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry

Author

Lachmann, H.J., Papa, R., Gerhold, K., Obici, L., Touitou, I., Cantarini, L., Frenkel, J., Anton, J., Kone-Paut, I., Cattalini, M., Bader-Meunier, B., Insalaco, A., Hentgen, V., Merino, R., Modesto, C., Toplak, N., Berendes, R., Ozen, S., Cimaz, R., Jansson, A., Brogan, P.T., Hawkins, P.N., Ruperto, N., Martini, A., Woo, P., Gattorno, M., Advances in Veterinary Medicine, Dep Gezondheidszorg Paard, ES AVM, University College of London [London] (UCL), Istituto Giannina Gaslini, Genova, Immunologia Clinica e Sperimentale, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Fondazione IRCCS Policlinico San Matteo [Pavia], Università di Pavia, Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Rheumatology Unit [Siena], University Medical Center [Utrecht], Universitat de Barcelona (UB), Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses [CH Versailles] (CeRéMAIA - Hôpital André Mignot), Centre Hospitalier de Versailles André Mignot (CHV), Università degli Studi di Brescia [Brescia], Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Hospital Universitario La Paz [Madrid, Espagne], Vall d'Hebron University Hospital [Barcelona], University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Azienda Ospedaliero Universitaria Meyer, Ludwig-Maximilians-Universität München (LMU), This project is supported by the Executive Agency for Health and Consumers of the European Union (EAHC, Project Nos 2007332 and 200923) and by Coordination Theme 1 (Health) of the European Community’s FP7, grant agreement number HEALTH-F2-2008-200923. Unrestricted educational grants were also kindly provided by PRINTO and Novartis, European Project: 200923,EC:FP7:HEALTH,FP7-HEALTH-2007-A,EUROTRAPS(2008), Università degli Studi di Pavia = University of Pavia (UNIPV), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Università degli Studi di Brescia = University of Brescia (UniBs), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Philips, Alexandre, Natural course, pathophysiology, models for early diagnosis, prevention and innovative treatment of TNF Receptor Associated Periodic Syndrome TRAPS with application for all hereditary recurrent fevers - EUROTRAPS - - EC:FP7:HEALTH2008-04-01 - 2011-09-30 - 200923 - VALID, Çocuk Sağlığı ve Hastalıkları, Advances in Veterinary Medicine, Dep Gezondheidszorg Paard, ES AVM, and Universitat de Barcelona

Subjects
Male, Abdominal pain, Time Factors, Fever Syndromes, Type I, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Cohort Studies, 0302 clinical medicine, AA amyloidosis, Receptors, Malalties hereditàries, Immunology and Allergy, amyloidosis, fever syndromes, inflammation, Pediatric rheumatology, Registries, Family history, Child, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, 0303 health sciences, Amyloidosis, Middle Aged, Inflamació, Rash, 3. Good health, Phenotype, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Receptors, Tumor Necrosis Factor, Type I, TNF receptor associated periodic syndrome, Child, Preschool, Disease Progression, Female, Headaches, medicine.symptom, Genetic diseases, Adult, medicine.medical_specialty, Adolescent, Fever, Genotype, Immunology, Pain, General Biochemistry, Genetics and Molecular Biology, Young Adult, 03 medical and health sciences, Rheumatology, Febre, Internal medicine, medicine, Humans, Reumatologia pediàtrica, Preschool, [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity, Aged, Retrospective Studies, 030304 developmental biology, Inflammation, 030203 arthritis & rheumatology, business.industry, Hereditary Autoinflammatory Diseases, Retrospective cohort study, Clinical and Epidemiological Research, Exanthema, Autoinflammatory Syndrome, medicine.disease, Surgery, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Tumor Necrosis Factor, business
Abstract

International audience; Objective To evaluate the genetic findings, demographic features and clinical presentation of tumour necrosis factor receptor-associated autoinflammatory syndrome (TRAPS) in patients from the Eurofever/EUROTRAPS international registry.Methods A web-based registry collected retrospective data on patients with TNFRSF1A sequence variants and inflammatory symptoms. Participating hospitals included paediatric rheumatology centres and adult centres with a specific interest in autoinflammatory diseases. Cases were independently validated by experts in the disease.Results Complete information on 158 validated patients was available. The most common TNFRSF1A variant was R92Q (34% of cases), followed by T50M (10%). Cysteine residues were disrupted in 27% of cases, accounting for 39% of sequence variants. A family history was present in 19% of patients with R92Q and 64% of those with other variants. The median age at which symptoms began was 4.3 years but 9.1% of patients presented after 30 years of age. Attacks were recurrent in 88% and the commonest features associated with the pathogenic variants were fever (88%), limb pain (85%), abdominal pain (74%), rash (63%) and eye manifestations (45%). Disease associated with R92Q presented slightly later at a median of 5.7 years with significantly less rash or eye signs and more headaches. Children were more likely than adults to present with lymphadenopathy, periorbital oedema and abdominal pains. AA amyloidosis has developed in 16 (10%) patients at a median age of 43 years.Conclusions In this, the largest reported case series to date, the genetic heterogeneity of TRAPS is accompanied by a variable phenotype at presentation. Patients had a median 70 symptomatic days a year, with fever, limb and abdominal pain and rash the commonest symptoms. Overall, there is little evidence of a significant effect of age or genotype on disease features at presentation.

Published
2013
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44. Temporäre Colchizinbehandlung bei heterozygoten FMF-Patienten

Author

Hitzegrad, A, Klotsche, J, Lainka, E, Niehues, T, Neudorf, U, Rietschel, C, Berendes, R, Lutz, T, Oommen, PT, Föll, D, Wittkowski, H, Kallinich, T, Hitzegrad, A, Klotsche, J, Lainka, E, Niehues, T, Neudorf, U, Rietschel, C, Berendes, R, Lutz, T, Oommen, PT, Föll, D, Wittkowski, H, and Kallinich, T

Published
2017

45. Combination of clinical parameters and biomarkers for the prediction of colchicine dose increase in patients with Familial Mediterranean Fever

Author

Knieper, AM, Klotsche, J, Lainka, E, Jansson, AF, Niehues, T, Neudorf, U, Oommen, PT, Berendes, R, Dressler, F, Berger, T, Rietschel, C, Foell, D, Wittkowski, H, Kallinich, T, Knieper, AM, Klotsche, J, Lainka, E, Jansson, AF, Niehues, T, Neudorf, U, Oommen, PT, Berendes, R, Dressler, F, Berger, T, Rietschel, C, Foell, D, Wittkowski, H, and Kallinich, T

Published
2017

46. Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Author

Ablyazimov, T., Abuhoza, A., Adak, R. P., Adamczyk, M., Agarwal, K., Aggarwal, M. M., Ahammed, Z., Ahmad, F., Ahmad, N., Ahmad, S., Akindinov, A., Akishin, P., Akishina, E., Akishina, T., Akishina, V., Akram, A., Al-Turany, M., Alekseev, I., Alexandrov, E., Alexandrov, I., Amar-Youcef, S., Anđelić, M., Andreeva, O., Andrei, C., Andronic, A., Anisimov, Y., Appelshäuser, H., Argintaru, D., Atkin, E., Avdeev, S., Averbeck, R., Azmi, M. D., Baban, V., Bach, M., Badura, E., Bähr, S., Balog, T., Balzer, M., Bao, E., Baranova, N., Barczyk, T., Bartoş, D., Bashir, S., Baszczyk, M., Batenkov, O., Baublis, V., Baznat, M., Becker, J., Becker, K.-H., Belogurov, S., Belyakov, D., Bendarouach, J., Berceanu, I., Bercuci, A., Berdnikov, A., Berdnikov, Y., Berendes, R., Berezin, G., Bergmann, C., Bertini, D., Bertini, O., Beşliu, C., Bezshyyko, O., Bhaduri, P. P., Bhasin, A., Bhati, A. K., Bhattacharjee, B., Bhattacharyya, A., Bhattacharyya, T. K., Biswas, S., Blank, T., Blau, D., Blinov, V., Blume, C., Bocharov, Y., Book, J., Breitner, T., Brüning, U., Brzychczyk, J., Bubak, A., Büsching, H., Bus, T., Butuzov, V., Bychkov, A., Byszuk, A., Cai, X., Cálin, M., Cao, P., Caragheorgheopol, G., Carević, I., Cătănescu, V., Chakrabarti, A., Chattopadhyay, S., Chaus, A., Chen, H., Chen, L., Chen, J., Chepurnov, V., Cherif, H., Chernogorov, A., Ciobanu, M. I., Claus, G., Constantin, F., Csanád, M., D'Ascenzo, N., Das, S., Cuveland, J., Debnath, B., Dementiev, D., Deng, W., Deng, C., Deppe, H., Deppner, I., Derenovskaya, O., Deveaux, C. A., Deveaux, M., Dey, K., Dey, M., Dillenseger, P., Dobyrn, V., Doering, D., Dong, S., Dorokhov, A., Dreschmann, M., Drozd, A., Dubey, A. K., Dubnichka, S., Dubnichkova, Z., Dürr, M., Dutka, L., Dželalija, M., Elsha, V. V., Emschermann, D., Engel, H., Eremin, V., Eşanu, T., Eschke, J., Eschweiler, D., Fan, H., Fan, X., Farooq, M., Fateev, O., Feng, S., Figuli, S. P. D., Filozova, I., Finogeev, D., Fischer, P., Flemming, H., Förtsch, J., Frankenfeld, U., Friese, V., Friske, E., Fröhlich, I., Frühauf, J., Gajda, J., Galatyuk, T., Gangopadhyay, G., García Chávez, C., Gebelein, J., Ghosh, P., Ghosh, S. K., Gläßel, S., Goffe, M., Golinka-Bezshyyko, L., Golovatyuk, V., Golovnya, S., Golovtsov, V., Golubeva, M., Golubkov, D., Gómez Ramírez, A., Gorbunov, S., Gorokhov, S., Gottschalk, D., Gryboś, P., Grzeszczuk, A., Guber, F., Gudima, K., Gumiński, M., Gupta, A., Gusakov, Y., Han, D., Hartmann, H., He, S., Hehner, J., Heine, N., Herghelegiu, A., Herrmann, N., Heß, B., Heuser, J. M., Himmi, A., Höhne, C., Holzmann, R., Hu, D., Huang, G., Huang, X., Hutter, D., Ierusalimov, A., Ilgenfritz, E.-M., Irfan, M., Ivanischev, D., Ivanov, M., Ivanov, P., Ivanov, V., Ivashkin, A., Jaaskelainen, K., Jahan, H., Jain, V., Jakovlev, V., Janson, T., Jiang, D., Jipa, A., Kadenko, I., Kähler, P., Kämpfer, B., Kalinin, V., Kallunkathariyil, J., Kampert, K.-H., Kaptur, E., Karabowicz, R., Karavichev, O., Karavicheva, T., Karmanov, D., Karnaukhov, V., Karpechev, E., Kasiński, K., Kasprowicz, G., Kaur, M., Kazantsev, A., Kebschull, U., Kekelidze, G., Khan, M. M., Khan, S. A., Khanzadeev, A., Khasanov, F., Khvorostukhin, A., Kirakosyan, V., Kirejczyk, M., Kiryakov, A., Kiš, M., Kisel, I., Kisel, P., Kiselev, S., Kiss, T., Klaus, P., Kłeczek, R., Klein-Bösing, C., Kleipa, V., Klochkov, V., Kmon, P., Koch, K., Kochenda, L., Koczoń, P., Koenig, W., Kohn, M., Kolb, B. W., Kolosova, A., Komkov, B., Korolev, M., Korolko, I., Kotte, R., Kovalchuk, A., Kowalski, S., Koziel, M., Kozlov, G., Kozlov, V., Kramarenko, V., Kravtsov, P., Krebs, E., Kreidl, C., Kres, I., Kresan, D., Kretschmar, G., Krieger, M., Kryanev, A. V., Kryshen, E., Kuc, M., Kucewicz, W., Kucher, V., Kudin, L., Kugler, A., Kumar, A., Kumar, L., Kunkel, J., Kurepin, A., Kurepin, N., Kurilkin, A., Kurilkin, P., Kushpil, V., Kuznetsov, S., Kyva, V., Ladygin, V., Lara, C., Larionov, P., Laso García, A., Lavrik, E., Lazanu, I., Lebedev, A., Lebedev, S., Lebedeva, E., Lehnert, J., Lehrbach, J., Leifels, Y., Lemke, F., Li, C., Li, Q., Li, X., Li, Y., Lindenstruth, V., Linnik, B., Liu, F., Lobanov, I., Lobanova, E., Löchner, S., Loizeau, P.-A., Lone, S. A., Lucio Martínez, J. A., Luo, X., Lymanets, A., Lyu, P., Maevskaya, A., Mahajan, S., Mahapatra, D. P., Mahmoud, T., Maj, P., Majka, Z., Malakhov, A., Malankin, E., Malkevich, D., Malyatina, O., Malygina, H., Mandal, M. M., Mandal, S., Manko, V., Manz, S., Marin Garcia, A. M., Markert, J., Masciocchi, S., Matulewicz, T., Meder, L., Merkin, M., Mialkovski, V., Michel, J., Miftakhov, N., Mik, L., Mikhailov, K., Mikhaylov, V., Milanović, B., Militsija, V., Miskowiec, D., Momot, I., Morhardt, T., Morozov, S., Müller, W. F. J., Müntz, C., Mukherjee, S., Muńoz Castillo, C. E., Murin, Y., Najman, R., Nandi, C., Nandy, E., Naumann, L., Nayak, T., Nedosekin, A., Negi, V. S., Niebur, W., Nikulin, V., Normanov, D., Oancea, A., Oh, K., Onishchuk, Y., Ososkov, G., Otfinowski, P., Ovcharenko, E., Pal, S., Panasenko, I., Panda, N. R., Parzhitskiy, S., Patel, V., Pauly, C., Penschuck, M., Peshekhonov, D., Peshekhonov, V., Petráček, V., Petri, M., Petriş, M., Petrovici, A., Petrovici, M., Petrovskiy, A., Petukhov, O., Pfeifer, D., Piasecki, K., Pieper, J., Pietraszko, J., Płaneta, R., Plotnikov, V., Plujko, V., Pluta, J., Pop, A., Pospisil, V., Poźniak, K., Prakash, A., Prasad, S. K., Prokudin, M., Pshenichnov, I., Pugach, M., Pugatch, V., Querchfeld, S., Rabtsun, S., Radulescu, L., Raha, S., Rami, F., Raniwala, R., Raniwala, S., Raportirenko, A., Rautenberg, J., Rauza, J., Ray, R., Razin, S., Reichelt, P., Reinecke, S., Reinefeld, A., Reshetin, A., Ristea, C., Ristea, O., Rodriguez Rodriguez, A., Roether, F., Romaniuk, R., Rost, A., Rostchin, E., Rostovtseva, I., Roy, A., Rożynek, J., Ryabov, Y., Sadovsky, A., Sahoo, R., Sahu, P. K., Sahu, S. K., Saini, J., Samanta, S., Sambyal, S. S., Samsonov, V., Sánchez Rosado, J., Sander, O., Sarangi, S., Satława, T., Sau, S., Saveliev, V., Schatral, S., Schiaua, C., Schintke, F., Schmidt, C. J., Schmidt, H. R., Schmidt, K., Scholten, J., Schweda, K., Seck, F., Seddiki, S., Selyuzhenkov, I., Semennikov, A., Senger, A., Senger, P., Shabanov, A., Shabunov, A., Shao, M., Sheremetiev, A. D., Shi, S., Shumeiko, N., Shumikhin, V., Sibiryak, I., Sikora, B., Simakov, A., Simon, C., Simons, C., Singaraju, R. N., Singh, A. K., Singh, B. K., Singh, C. P., Singhal, V., Singla, M., Sitzmann, P., Siwek-Wilczyńska, K., Skwira-Chalot, I., Som, I., Song, G., Song, J., Sosin, Z., Soyk, D., Staszel, P., Strikhanov, M., Strohauer, S., Stroth, J., Sturm, C., Sultanov, R., Sun, Y., Svirida, D., Svoboda, O., Szabó, A., Szczygieł, R., Talukdar, R., Tang, Z., Tanha, M., Tarasiuk, J., Tarassenkova, O., Târzilă, M.-G., Teklishyn, M., Tischler, T., Tlustý, P., Tölyhi, T., Toia, A., Topil'Skaya, N., Träger, M., Tripathy, S., Tsakov, I., Tsyupa, Y., Turowiecki, A., Tuturas, N. G., Uhlig, F., Usenko, E., Valin, I., Varga, D., Vassiliev, I., Vasylyev, O., Verbitskaya, E., Verhoeven, W., Veshikov, A., Visinka, R., Viyogi, Y. P., Volkov, S., Volochniuk, A., Vorobiev, A., Voronin, A., Vovchenko, V., Vznuzdaev, M., Wang, D., Wang, X.-W., Wang, Y., Weber, M., Wendisch, C., Wessels, J. P., Wiebusch, M., Wiechula, J., Wielanek, D., Wieloch, A., Wilms, A., Winckler, N., Winter, M., Wiśniewski, K., Wolf, G., Won, S., Wu, K.-J., Wüstenfeld, J., Xiang, C., Xu, N., Yang, J., Yang, R., Yin, Z., Yoo, I.-K., Yuldashev, B., Yushmanov, I., Zabołotny, W., Zaitsev, Y., Zamiatin, N. I., Zanevsky, Y., Zhalov, M., Zhang, Y., Zhao, L., Zheng, J., Zheng, S., Zhou, D., Zhou, J., Zhu, X., Zinchenko, A., Zipper, W., Zrelov, M., Zryuev, V., Zumbruch, P., Zyzak, M., Ablyazimov, T., Abuhoza, A., Adak, R. P., Adamczyk, M., Agarwal, K., Aggarwal, M. M., Ahammed, Z., Ahmad, F., Ahmad, N., Ahmad, S., Akindinov, A., Akishin, P., Akishina, E., Akishina, T., Akishina, V., Akram, A., Al-Turany, M., Alekseev, I., Alexandrov, E., Alexandrov, I., Amar-Youcef, S., Anđelić, M., Andreeva, O., Andrei, C., Andronic, A., Anisimov, Y., Appelshäuser, H., Argintaru, D., Atkin, E., Avdeev, S., Averbeck, R., Azmi, M. D., Baban, V., Bach, M., Badura, E., Bähr, S., Balog, T., Balzer, M., Bao, E., Baranova, N., Barczyk, T., Bartoş, D., Bashir, S., Baszczyk, M., Batenkov, O., Baublis, V., Baznat, M., Becker, J., Becker, K.-H., Belogurov, S., Belyakov, D., Bendarouach, J., Berceanu, I., Bercuci, A., Berdnikov, A., Berdnikov, Y., Berendes, R., Berezin, G., Bergmann, C., Bertini, D., Bertini, O., Beşliu, C., Bezshyyko, O., Bhaduri, P. P., Bhasin, A., Bhati, A. K., Bhattacharjee, B., Bhattacharyya, A., Bhattacharyya, T. K., Biswas, S., Blank, T., Blau, D., Blinov, V., Blume, C., Bocharov, Y., Book, J., Breitner, T., Brüning, U., Brzychczyk, J., Bubak, A., Büsching, H., Bus, T., Butuzov, V., Bychkov, A., Byszuk, A., Cai, X., Cálin, M., Cao, P., Caragheorgheopol, G., Carević, I., Cătănescu, V., Chakrabarti, A., Chattopadhyay, S., Chaus, A., Chen, H., Chen, L., Chen, J., Chepurnov, V., Cherif, H., Chernogorov, A., Ciobanu, M. I., Claus, G., Constantin, F., Csanád, M., D'Ascenzo, N., Das, S., Cuveland, J., Debnath, B., Dementiev, D., Deng, W., Deng, C., Deppe, H., Deppner, I., Derenovskaya, O., Deveaux, C. A., Deveaux, M., Dey, K., Dey, M., Dillenseger, P., Dobyrn, V., Doering, D., Dong, S., Dorokhov, A., Dreschmann, M., Drozd, A., Dubey, A. K., Dubnichka, S., Dubnichkova, Z., Dürr, M., Dutka, L., Dželalija, M., Elsha, V. V., Emschermann, D., Engel, H., Eremin, V., Eşanu, T., Eschke, J., Eschweiler, D., Fan, H., Fan, X., Farooq, M., Fateev, O., Feng, S., Figuli, S. P. D., Filozova, I., Finogeev, D., Fischer, P., Flemming, H., Förtsch, J., Frankenfeld, U., Friese, V., Friske, E., Fröhlich, I., Frühauf, J., Gajda, J., Galatyuk, T., Gangopadhyay, G., García Chávez, C., Gebelein, J., Ghosh, P., Ghosh, S. K., Gläßel, S., Goffe, M., Golinka-Bezshyyko, L., Golovatyuk, V., Golovnya, S., Golovtsov, V., Golubeva, M., Golubkov, D., Gómez Ramírez, A., Gorbunov, S., Gorokhov, S., Gottschalk, D., Gryboś, P., Grzeszczuk, A., Guber, F., Gudima, K., Gumiński, M., Gupta, A., Gusakov, Y., Han, D., Hartmann, H., He, S., Hehner, J., Heine, N., Herghelegiu, A., Herrmann, N., Heß, B., Heuser, J. M., Himmi, A., Höhne, C., Holzmann, R., Hu, D., Huang, G., Huang, X., Hutter, D., Ierusalimov, A., Ilgenfritz, E.-M., Irfan, M., Ivanischev, D., Ivanov, M., Ivanov, P., Ivanov, V., Ivashkin, A., Jaaskelainen, K., Jahan, H., Jain, V., Jakovlev, V., Janson, T., Jiang, D., Jipa, A., Kadenko, I., Kähler, P., Kämpfer, B., Kalinin, V., Kallunkathariyil, J., Kampert, K.-H., Kaptur, E., Karabowicz, R., Karavichev, O., Karavicheva, T., Karmanov, D., Karnaukhov, V., Karpechev, E., Kasiński, K., Kasprowicz, G., Kaur, M., Kazantsev, A., Kebschull, U., Kekelidze, G., Khan, M. M., Khan, S. A., Khanzadeev, A., Khasanov, F., Khvorostukhin, A., Kirakosyan, V., Kirejczyk, M., Kiryakov, A., Kiš, M., Kisel, I., Kisel, P., Kiselev, S., Kiss, T., Klaus, P., Kłeczek, R., Klein-Bösing, C., Kleipa, V., Klochkov, V., Kmon, P., Koch, K., Kochenda, L., Koczoń, P., Koenig, W., Kohn, M., Kolb, B. W., Kolosova, A., Komkov, B., Korolev, M., Korolko, I., Kotte, R., Kovalchuk, A., Kowalski, S., Koziel, M., Kozlov, G., Kozlov, V., Kramarenko, V., Kravtsov, P., Krebs, E., Kreidl, C., Kres, I., Kresan, D., Kretschmar, G., Krieger, M., Kryanev, A. V., Kryshen, E., Kuc, M., Kucewicz, W., Kucher, V., Kudin, L., Kugler, A., Kumar, A., Kumar, L., Kunkel, J., Kurepin, A., Kurepin, N., Kurilkin, A., Kurilkin, P., Kushpil, V., Kuznetsov, S., Kyva, V., Ladygin, V., Lara, C., Larionov, P., Laso García, A., Lavrik, E., Lazanu, I., Lebedev, A., Lebedev, S., Lebedeva, E., Lehnert, J., Lehrbach, J., Leifels, Y., Lemke, F., Li, C., Li, Q., Li, X., Li, Y., Lindenstruth, V., Linnik, B., Liu, F., Lobanov, I., Lobanova, E., Löchner, S., Loizeau, P.-A., Lone, S. A., Lucio Martínez, J. A., Luo, X., Lymanets, A., Lyu, P., Maevskaya, A., Mahajan, S., Mahapatra, D. P., Mahmoud, T., Maj, P., Majka, Z., Malakhov, A., Malankin, E., Malkevich, D., Malyatina, O., Malygina, H., Mandal, M. M., Mandal, S., Manko, V., Manz, S., Marin Garcia, A. M., Markert, J., Masciocchi, S., Matulewicz, T., Meder, L., Merkin, M., Mialkovski, V., Michel, J., Miftakhov, N., Mik, L., Mikhailov, K., Mikhaylov, V., Milanović, B., Militsija, V., Miskowiec, D., Momot, I., Morhardt, T., Morozov, S., Müller, W. F. J., Müntz, C., Mukherjee, S., Muńoz Castillo, C. E., Murin, Y., Najman, R., Nandi, C., Nandy, E., Naumann, L., Nayak, T., Nedosekin, A., Negi, V. S., Niebur, W., Nikulin, V., Normanov, D., Oancea, A., Oh, K., Onishchuk, Y., Ososkov, G., Otfinowski, P., Ovcharenko, E., Pal, S., Panasenko, I., Panda, N. R., Parzhitskiy, S., Patel, V., Pauly, C., Penschuck, M., Peshekhonov, D., Peshekhonov, V., Petráček, V., Petri, M., Petriş, M., Petrovici, A., Petrovici, M., Petrovskiy, A., Petukhov, O., Pfeifer, D., Piasecki, K., Pieper, J., Pietraszko, J., Płaneta, R., Plotnikov, V., Plujko, V., Pluta, J., Pop, A., Pospisil, V., Poźniak, K., Prakash, A., Prasad, S. K., Prokudin, M., Pshenichnov, I., Pugach, M., Pugatch, V., Querchfeld, S., Rabtsun, S., Radulescu, L., Raha, S., Rami, F., Raniwala, R., Raniwala, S., Raportirenko, A., Rautenberg, J., Rauza, J., Ray, R., Razin, S., Reichelt, P., Reinecke, S., Reinefeld, A., Reshetin, A., Ristea, C., Ristea, O., Rodriguez Rodriguez, A., Roether, F., Romaniuk, R., Rost, A., Rostchin, E., Rostovtseva, I., Roy, A., Rożynek, J., Ryabov, Y., Sadovsky, A., Sahoo, R., Sahu, P. K., Sahu, S. K., Saini, J., Samanta, S., Sambyal, S. S., Samsonov, V., Sánchez Rosado, J., Sander, O., Sarangi, S., Satława, T., Sau, S., Saveliev, V., Schatral, S., Schiaua, C., Schintke, F., Schmidt, C. J., Schmidt, H. R., Schmidt, K., Scholten, J., Schweda, K., Seck, F., Seddiki, S., Selyuzhenkov, I., Semennikov, A., Senger, A., Senger, P., Shabanov, A., Shabunov, A., Shao, M., Sheremetiev, A. D., Shi, S., Shumeiko, N., Shumikhin, V., Sibiryak, I., Sikora, B., Simakov, A., Simon, C., Simons, C., Singaraju, R. N., Singh, A. K., Singh, B. K., Singh, C. P., Singhal, V., Singla, M., Sitzmann, P., Siwek-Wilczyńska, K., Skwira-Chalot, I., Som, I., Song, G., Song, J., Sosin, Z., Soyk, D., Staszel, P., Strikhanov, M., Strohauer, S., Stroth, J., Sturm, C., Sultanov, R., Sun, Y., Svirida, D., Svoboda, O., Szabó, A., Szczygieł, R., Talukdar, R., Tang, Z., Tanha, M., Tarasiuk, J., Tarassenkova, O., Târzilă, M.-G., Teklishyn, M., Tischler, T., Tlustý, P., Tölyhi, T., Toia, A., Topil'Skaya, N., Träger, M., Tripathy, S., Tsakov, I., Tsyupa, Y., Turowiecki, A., Tuturas, N. G., Uhlig, F., Usenko, E., Valin, I., Varga, D., Vassiliev, I., Vasylyev, O., Verbitskaya, E., Verhoeven, W., Veshikov, A., Visinka, R., Viyogi, Y. P., Volkov, S., Volochniuk, A., Vorobiev, A., Voronin, A., Vovchenko, V., Vznuzdaev, M., Wang, D., Wang, X.-W., Wang, Y., Weber, M., Wendisch, C., Wessels, J. P., Wiebusch, M., Wiechula, J., Wielanek, D., Wieloch, A., Wilms, A., Winckler, N., Winter, M., Wiśniewski, K., Wolf, G., Won, S., Wu, K.-J., Wüstenfeld, J., Xiang, C., Xu, N., Yang, J., Yang, R., Yin, Z., Yoo, I.-K., Yuldashev, B., Yushmanov, I., Zabołotny, W., Zaitsev, Y., Zamiatin, N. I., Zanevsky, Y., Zhalov, M., Zhang, Y., Zhao, L., Zheng, J., Zheng, S., Zhou, D., Zhou, J., Zhu, X., Zinchenko, A., Zipper, W., Zrelov, M., Zryuev, V., Zumbruch, P., and Zyzak, M.

Abstract

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.

Published
2017

47. Vereinssport bei juveniler idiopathischer Arthritis – Ergebnisse des Sportmoduls im Rahmen der Kerndokumentation rheumakranker Kinder und Jugendlicher

Author

Milatz, F, Niewerth, M, Geisemeyer, N, Hartmann, M, Peitz, J, Berendes, R, Thon, A, Huppertz, HI, and Minden, K

Subjects
Sportverein, ddc: 610, Kinder und Jugendliche, 610 Medical sciences, Medicine, juvenile idiopathische Arthritis
Abstract

Einleitung: Der Sportverein gilt als ein wichtiges soziales Handlungsfeld und kann damit einen bedeutenden Beitrag für das psychosoziale Wohlbefinden, die Persönlichkeitsentwicklung und das Erlernen sozialer Kompetenzen leisten. Chronisch-rheumatische Erkrankungen, wie die juvenile idiopathische[zum vollständigen Text gelangen Sie über die oben angegebene URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2016
Full Text
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48. Trends in der medikamentösen Therapie und im gesundheitlichen Befinden von Patienten mit hereditären periodischen Fiebersyndromen (HPF) in den letzten 10 Jahren

Author

Niewerth, M, Kallinich, T, Hospach, A, Thon, A, Berendes, R, and Minden, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Patienten mit HPF leiden unter verschiedenen Beschwerden, u.a. Fieber, Schmerzen und chronische Müdigkeit. Über das Ausmaß krankheitsbedingter Belastungen im Alltag und deren Veränderungen in den vergangenen 10 Jahren ist bisher wenig bekannt. Methoden: Daten von Patienten[zum vollständigen Text gelangen Sie über die oben angegebene URL], 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2015
Full Text
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49. Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Author

Ablyazimov, T., Abuhoza, A., Adak, R. P., Adamczyk, M., Agarwal, K., Aggarwal, M. M., Ahammed, Z., Ahmad, F., Ahmad, N., Ahmad, S., Akindinov, A., Akishin, P., Akishina, E., Akishina, T., Akishina, V., Akram, A., Al-Turany, M., Alekseev, I., Alexandrov, E., Alexandrov, I., Amar-Youcef, S., Anđelić, M., Andreeva, O., Andrei, C., Andronic, A., Anisimov, Y., Appelshäuser, H., Argintaru, D., Atkin, E., Avdeev, S., Averbeck, R., Azmi, M. D., Baban, V., Bach, M., Badura, E., Bähr, S., Balog, T., Balzer, M., Bao, E., Baranova, N., Barczyk, T., Bartoş, D., Bashir, S., Baszczyk, M., Batenkov, O., Baublis, V., Baznat, M., Becker, J., Becker, K.-H., Belogurov, S., Belyakov, D., Bendarouach, J., Berceanu, I., Bercuci, A., Berdnikov, A., Berdnikov, Y., Berendes, R., Berezin, G., Bergmann, C., Bertini, D., Bertini, O., Beşliu, C., Bezshyyko, O., Bhaduri, P. P., Bhasin, A., Bhati, A. K., Bhattacharjee, B., Bhattacharyya, A., Bhattacharyya, T. K., Biswas, S., Blank, T., Blau, D., Blinov, V., Blume, C., Bocharov, Y., Book, J., Breitner, T., Brüning, U., Brzychczyk, J., Bubak, A., Büsching, H., Bus, T., Butuzov, V., Bychkov, A., Byszuk, A., Cai, X., Cálin, M., Cao, P., Caragheorgheopol, G., Carević, I., Cătănescu, V., Chakrabarti, A., Chattopadhyay, S., Chaus, A., Chen, H., Chen, L., Chen, J., Chepurnov, V., Cherif, H., Chernogorov, A., Ciobanu, M. I., Claus, G., Constantin, F., Csanád, M., D'Ascenzo, N., Das, S., Cuveland, J., Debnath, B., Dementiev, D., Deng, W., Deng, C., Deppe, H., Deppner, I., Derenovskaya, O., Deveaux, C. A., Deveaux, M., Dey, K., Dey, M., Dillenseger, P., Dobyrn, V., Doering, D., Dong, S., Dorokhov, A., Dreschmann, M., Drozd, A., Dubey, A. K., Dubnichka, S., Dubnichkova, Z., Dürr, M., Dutka, L., Dželalija, M., Elsha, V. V., Emschermann, D., Engel, H., Eremin, V., Eşanu, T., Eschke, J., Eschweiler, D., Fan, H., Fan, X., Farooq, M., Fateev, O., Feng, S., Figuli, S. P. D., Filozova, I., Finogeev, D., Fischer, P., Flemming, H., Förtsch, J., Frankenfeld, U., Friese, V., Friske, E., Fröhlich, I., Frühauf, J., Gajda, J., Galatyuk, T., Gangopadhyay, G., García Chávez, C., Gebelein, J., Ghosh, P., Ghosh, S. K., Gläßel, S., Goffe, M., Golinka-Bezshyyko, L., Golovatyuk, V., Golovnya, S., Golovtsov, V., Golubeva, M., Golubkov, D., Gómez Ramírez, A., Gorbunov, S., Gorokhov, S., Gottschalk, D., Gryboś, P., Grzeszczuk, A., Guber, F., Gudima, K., Gumiński, M., Gupta, A., Gusakov, Y., Han, D., Hartmann, H., He, S., Hehner, J., Heine, N., Herghelegiu, A., Herrmann, N., Heß, B., Heuser, J. M., Himmi, A., Höhne, C., Holzmann, R., Hu, D., Huang, G., Huang, X., Hutter, D., Ierusalimov, A., Ilgenfritz, E.-M., Irfan, M., Ivanischev, D., Ivanov, M., Ivanov, P., Ivanov, V., Ivashkin, A., Jaaskelainen, K., Jahan, H., Jain, V., Jakovlev, V., Janson, T., Jiang, D., Jipa, A., Kadenko, I., Kähler, P., Kämpfer, B., Kalinin, V., Kallunkathariyil, J., Kampert, K.-H., Kaptur, E., Karabowicz, R., Karavichev, O., Karavicheva, T., Karmanov, D., Karnaukhov, V., Karpechev, E., Kasiński, K., Kasprowicz, G., Kaur, M., Kazantsev, A., Kebschull, U., Kekelidze, G., Khan, M. M., Khan, S. A., Khanzadeev, A., Khasanov, F., Khvorostukhin, A., Kirakosyan, V., Kirejczyk, M., Kiryakov, A., Kiš, M., Kisel, I., Kisel, P., Kiselev, S., Kiss, T., Klaus, P., Kłeczek, R., Klein-Bösing, C., Kleipa, V., Klochkov, V., Kmon, P., Koch, K., Kochenda, L., Koczoń, P., Koenig, W., Kohn, M., Kolb, B. W., Kolosova, A., Komkov, B., Korolev, M., Korolko, I., Kotte, R., Kovalchuk, A., Kowalski, S., Koziel, M., Kozlov, G., Kozlov, V., Kramarenko, V., Kravtsov, P., Krebs, E., Kreidl, C., Kres, I., Kresan, D., Kretschmar, G., Krieger, M., Kryanev, A. V., Kryshen, E., Kuc, M., Kucewicz, W., Kucher, V., Kudin, L., Kugler, A., Kumar, A., Kumar, L., Kunkel, J., Kurepin, A., Kurepin, N., Kurilkin, A., Kurilkin, P., Kushpil, V., Kuznetsov, S., Kyva, V., Ladygin, V., Lara, C., Larionov, P., Laso García, A., Lavrik, E., Lazanu, I., Lebedev, A., Lebedev, S., Lebedeva, E., Lehnert, J., Lehrbach, J., Leifels, Y., Lemke, F., Li, C., Li, Q., Li, X., Li, Y., Lindenstruth, V., Linnik, B., Liu, F., Lobanov, I., Lobanova, E., Löchner, S., Loizeau, P.-A., Lone, S. A., Lucio Martínez, J. A., Luo, X., Lymanets, A., Lyu, P., Maevskaya, A., Mahajan, S., Mahapatra, D. P., Mahmoud, T., Maj, P., Majka, Z., Malakhov, A., Malankin, E., Malkevich, D., Malyatina, O., Malygina, H., Mandal, M. M., Mandal, S., Manko, V., Manz, S., Marin Garcia, A. M., Markert, J., Masciocchi, S., Matulewicz, T., Meder, L., Merkin, M., Mialkovski, V., Michel, J., Miftakhov, N., Mik, L., Mikhailov, K., Mikhaylov, V., Milanović, B., Militsija, V., Miskowiec, D., Momot, I., Morhardt, T., Morozov, S., Müller, W. F. J., Müntz, C., Mukherjee, S., Muńoz Castillo, C. E., Murin, Y., Najman, R., Nandi, C., Nandy, E., Naumann, L., Nayak, T., Nedosekin, A., Negi, V. S., Niebur, W., Nikulin, V., Normanov, D., Oancea, A., Oh, K., Onishchuk, Y., Ososkov, G., Otfinowski, P., Ovcharenko, E., Pal, S., Panasenko, I., Panda, N. R., Parzhitskiy, S., Patel, V., Pauly, C., Penschuck, M., Peshekhonov, D., Peshekhonov, V., Petráček, V., Petri, M., Petriş, M., Petrovici, A., Petrovici, M., Petrovskiy, A., Petukhov, O., Pfeifer, D., Piasecki, K., Pieper, J., Pietraszko, J., Płaneta, R., Plotnikov, V., Plujko, V., Pluta, J., Pop, A., Pospisil, V., Poźniak, K., Prakash, A., Prasad, S. 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Abstract

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.

Published
2016

50. Arthrosonografische Normwerte im Kindes- und Jugendalter - Achillessehne

Author

Windschall, D, Trauzeddel, R, Lehmann, H, Ganser, G, Berendes, R, Haller, M, Krumrey-Langkammerer, M, Palm-Beden, K, Nimtz-Talaska, A, Nirschl, C, Schoof, P, Trauzeddel, F, Windschall, D, Trauzeddel, R, Lehmann, H, Ganser, G, Berendes, R, Haller, M, Krumrey-Langkammerer, M, Palm-Beden, K, Nimtz-Talaska, A, Nirschl, C, Schoof, P, and Trauzeddel, F

Published
2016

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