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1. Impact of vaccination on the presence and severity of symptoms in hospitalized patients with an infection of the Omicron variant (B.1.1.529) of the SARS-CoV-2 (subvariant BA.1)

Author

Beraud, Guillaume, Bouetard, Laura, Civljak, Rok, Michon, Jocelyn, Tulek, Necla, Lejeune, Sophie, Millot, Romain, Garchet-Beaudron, Aurélie, Lefebvre, Maeva, Velikov, Petar, Festou, Benjamin, Abgrall, Sophie, Lizatovic, Ivan K., Baldolli, Aurélie, Esmer, Huseyin, Blanchi, Sophie, Froidevaux, Gabrielle, Kapincheva, Nikol, Faucher, Jean-François, Duvnjak, Mario, Afşar, Elçin, Švitek, Luka, Yarimoglu, Saliha, Yarimoglu, Rafet, Janssen, Cécile, and Epaulard, Olivier

Published
2023
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3. Hydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial

Author

Brangier, Antoine, Codron, Philippe, Lemée, Jean Michel, Pichon, Virginie, Dhersin, Robin, Urbanski, Geoffrey, Lavigne, Christian, Courtois, Roxane, Danielou, Hélène, Lebreton, Jonathan, Vatan, Rémi, Crochette, Nicolas, Lainé, Jean-Baptiste, Perez, Lucia, Blanchi, Sophie, Hitoto, Hikombo, Bernard, Louis, Maillot, François, Marchand Adam, Sylvain, Talarmin, Jean-Philippe, Gaigneux, Emeline, Motte-Vincent, Pauline, Morrier, Marine, Merrien, Dominique, Bleher, Yves, Flori, Maxime, Ducet-Boiffard, Amélie, Colin, Orane, Février, Ronan, Thill, Pauline, Tetart, Macha, Demaeght, François, Lafond-Desmurs, Barthelemy, Pradier, Maxime, Meybeck, Agnes, Picaud, Marjorie, Prazuck, Thierry, Chapelet, Guillaume, Rouaud, Agnès, Le Turnier, Paul, Sunder, Simon, Lorleac'h, Aurélien, Dollon, Christophe, Jacquet, Antoine, Le Vely, Francois, Gazeau, Pierre, Ansart, Séverine, Roger, Hélène, Laterza, François, Buzelé, Rodolphe, Tahmi, Fella, Lepeule, Raphael, Lacombe, Karine, Lefebvre, Bénédicte, Célarier, Thomas, Gagneux-Brunon, Amandine, Botelho-Nevers, Elisabeth, Bernard, Marc, Garnier, Camille, Mourguet, Morgane, Pugnet, Gregory, Vienne-Noyes, Sara, Martin-Blondel, Guillaume, Delobel, Pierre, Grouteau, Gaspard, Debard, Alexa, Guilleminault, Laurent, Arias, Pauline, Chakvetadze, Catherine, Flateau, Clara, Kopp, Aude, Putot, Alain, Barben, Jeremy, Mouries Martin, Suzanne, Nuss, Valentine, Piroth, Lionel, Claessens, Yann-Erick, Hentgen, Veronique, Martinot, Martin, Bach-Bunner, Maxime, Bonijoly, Thomas, Gravier, Simon, Michel, Jean-Marc, Andreu, Mathilde, Roriz, Mélanie, Baldolli, Aurélie, Brochard, Julia, Grossi, Olivier, Pineau, Samuel, Brisset, Josselin, Desvaux, Edouard, Gondran, Guillaume, Faucher, Jean-François, Quesnel, Paul-Antoine, Bezanahary, Holy, Danthu, Clément, Gutierrez, Blandine, Ly, Kim, Simonneau, Yannick, Cypierre, Anne, Pinet, Pauline, Durox, Hélène, Ducroix-Roubertou, Sophie, Genet, Claire, Beraud, Guillaume, Le Moal, Gwenael, Rammaert, Blandine, Lanoix, Jean-Philippe, Andrejak, Claire, Joseph, Cédric, Soriot-Thomas, Sandrine, Dhote, Robin, Abad, Sébastien, Benainous, Ruben, Boitiaux, Jean-François, Briend, Guillaume, Gonfroy, Celine, Harent, Stanislas, Lagrange, Aurore, Tone, Alina, Wayenberg, Laura, Desoutter, Sophie, Ettahar, Nicolas, Gey, Thomas, Leroy, Vincent, Gaillard, Sacha, Toma, Andrea, Broussier, Amaury, Etienne, Sandrine, Spivac, Yann, Martha, Benoit, Roch, Nathalie, Diaz, Pierre, N’guyen Baranoff, Danièle, Rebaudet, Stanislas, Jourda, François, Zeller, Valérie, Bienvenu, Boris, Boyer, Arnaud, Pellier, Isabelle, Mercat, Alain, Darsonval, Astrid, Blanchet, Odile, Custaud, Marc-Antoine, Lefeuvre, Caroline, Parot-Schinkel, Elsa, Vielle, Bruno, Briet, Marie, Roy, Pierre-Marie, Dubée, Vincent, Guidet, Bertrand, Mismetti, Patrick, Vicaut, Eric, Sanchez, Olivier, Girard, Philippe, Elias, Antoine, Couturaud, Francis, Gable, Béatrice, Lazareff, Sybille, Carballido, Loïc, Hue, Catherine, Chrétien, Jean-Marie, Goraguer, Adrien, Eeckhoutte, Lucie van, Abbara, Chadi, Boucher, Sophie, Devaud, Edouard, Robineau, Olivier, Rispal, Patrick, Guimard, Thomas, d’Anglejean, Emma, and Diamantis, Sylvain

Published
2021
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4. Neurologic manifestations associated with COVID-19: a multicentre registry

Author

Abgrall, Sophie, Alby-Laurent, Fanny, Allou, Thibault, Amevigbe, Joséphine, Amarguellay, Hanifa, Alloussi, Nabil, Baille, Guillaume, Barbaz, Mathilde, Bekri, Imen, Bencherif, Lamia, Bensaadi, Samia, Beraud, Guillaume, Bizot, Alexandra, Bottin, Laure, Bruneel, Fabrice, Camdessanche, Jean-Philippe, Chauffier, Jeanne, Csajaghy, Jean-Philippe, De Broucker, Chloé, De Broucker, Thomas, Defebvre, Luc, Delorme, Cécile, Dembloque, Elodie, Derache, Nathalie, Dereeper, Olivier, Derollez, Céline, Descotes-Genon, Cécile, Desestret, Virginie, Devaux, Mathilde, Dubuc, Lydie, Edan, Gilles, Fickl, Andréa, Fraisse, Thibault, Gugenheim, Michel, Hankiewicz, Karolina, Hansmann, Yves, Hautecloque-Raysz, Geoffroy, Henry, Carole, Jobard, Stéphanie, Jouan, Fanny, Kwiatkowski, Arnaud, Lalu, Thibault, Landre, Sophie, Lannuzel, Annie, Leguilloux, Johan, Lejeune, Camille, Liegeois, Clémence, Mahy, Sophie, Marey, Jonathan, Maury, Alexandra, Meppiel, Elodie, Michel, Laure, Mitri, Rita, Moulin, Chloé, Moulin, Solène, Peiffer-Smadja, Nathan, Omarjee, Asma, Ozsancak, Canan, Perrin, Peggy, Petitgas, Paul, Pico, Fernando, Poupard, Marie, Rabier, Valérie, Rizzato, Camille, Roos, Caroline, Saison, Julien, Sayre, Naomi, Sedillot, Nicolas, Sellal, François, Servan, Jérôme, Storey, Caroline, Suchet, Laurent, Tarteret, Paul, Tattevin, Pierre, Thiebaut, Mathilde, Vaduva, Claudia, Varlan, David, Wang, Adrien, Zarrouk, Virginie, Gorza, Lucas, SellaI, François, and de Broucker, Thomas

Published
2021
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5. How Should we Use Multicolumn Spinal Cord Stimulation to Optimize Back Pain Spatial Neural Targeting? A Prospective, Multicenter, Randomized, Double-Blind, Controlled Trial (ESTIMET Study)

Author

Rigoard, Philippe, Billot, Maxime, Ingrand, Pierre, Durand-Zaleski, Isabelle, Roulaud, Manuel, Peruzzi, Philippe, Dam Hieu, Phong, Voirin, Jimmy, Raoul, Sylvie, Page, Philippe, Djian, Marie-Christine, Fontaine, Denys, Lantéri-Minet, Michel, Blond, Serge, Buisset, Nadia, Cuny, Emmanuel, Cadenne, Myriam, Caire, François, Ranoux, Danièle, Mertens, Patrick, Naous, Hussein, Simon, Emile, Emery, Evelyne, Béraud, Guillaume, Debiais, Françoise, Durand, Géraldine, Serrie, Alain, Diallo, Bakari, Bulsei, Julie, Ounajim, Amine, Nivole, Kevin, Duranton, Sophie, Naiditch, Nicolas, Monlezun, Olivier, and Bataille, Benoit

Published
2021
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6. Community-acquired bacterial meningitis in adults: in-hospital prognosis, long-term disability and determinants of outcome in a multicentre prospective cohort

Author

Duval, Xavier, Hoen, Bruno, Mourvillier, Bruno, Ploy, Marie-Cécile, Tubiana, Sarah, Varon, Emmanuelle, Caron, François, Bollaert, Pierre-Edouard, Gaillot, Olivier, Taha, Muhamed-Kheir, Poyart, Claire, Bonacorsi, Stephane, Vandenesch, François, Cambau, Emmanuelle, Lecuit, Marc, Gravet, Alain, Frachet, Bruno, Broucker, Thomas De, Levy Bruhl, Daniel, Raffi, François, Anguel, Nadia, Argaud, Laurent, Arista, Sophie, Armand-Lefevre, Laurence, Balavoine, Stéphanie, Baraduc, Régine, Barnaud, Guilène, Beraud, Guillaume, Bernard, Louis, Bernars, Georges, Bertei, Dominique, Bessede, Emilie, Billard Pomares, Typhaine, Biron, Charlotte, Bland, Stéphane, Boileau, Julien, Boubeau, Patrice, Bourdon, Sandra, Bousquet, Aurore, Boyer, Sophie, Bozorg-Grayeli, Alexis, Bret, Laurent, Bretonniere, Cédric, Bricaire, François, Brocas, Elsa, Brun, Michel, Buret, Jennifer, Burucoa, Christophe, Cabalion, Jean, Cabon, Mathieu, Camuset, Guillaume, Canevet, Christophe, Carricajo, Anne, Castan, Bernard, Caumes, Eric, Cazanave, Charles, Chabrol, Amélie, Challan-Belval, Thibaut, Chanteperdrix-Marillier, Vanessa, Chaplain, Chantal, Charlier-Woerther, Caroline, Chaussade, Hélène, Chirouze, Catherine, Clair, Bernard, Colot, Julien, Conil, Jean-Marie, Cordel, Hugues, Cormier, Philippe, Cousson, Joël, Cronier, Pierrick, Cua, Eric, Dao-Dubremetz, Anne, Dargere, Sylvie, Degand, Nicolas, Dekeyser, Sophie, Delaune, Deborah, Denes, Eric, Dequin, Pierre-Francois, Descamps, Diane, Descloux, Elodie, Desmaretz, Jean-Luc, Diehl, Jean-Luc, Dimet, Jérôme, Dinh, Aurélien, Escaut, Lelia, Fabe, Claude, Faibis, Frédéric, Flateau, Clara, Fonsale, Nathalie, Forestier, Emmanuel, Fortineau, Nicolas, Gagneux-Brunon, Amandine, Garandeau, Garcia, Magali, Garot, Denis, Gaudry, Stéphane, Goehringer, François, Gregoire-Faucher, Valérie, Grosset, Marine, Gubavu, Camélia, Gueit, Isabelle, Guelon, Dominique, Guimard, Thomas, Guinard, Jérôme, Hadou, Tahar, Helene, Jean-Pierre, Henard, Sandrine, Henry, Benoit, Hochart, Anne-Cécile, Illes, Gabriela, Jaffuel, Sylvain, Jarrin, Irène, Jaureguy, Françoise, Joseph, Cédric, Juvin, Marie-Emmanuelle, Kayal, Samer, Lacassin, Flore, Lamaury, Isabelle, Lanotte, Philippe, Laurens, Etienne, Laurichesse, Henri, Le Brun, Cécile, Le Moing, Vincent, Le Turnier, Paul, Lecuyer, Hervé, Ledru, Sylvie, Legrix, Céline, Lemaignen, Adrien, Lemble, Chantal, Lemee, Ludovic, Lesens, Olivier, Levast, Marion, Lhommet, Claire, Males, Silvija, Malpote, Edith, Martin-Blondel, Guillaume, Marx, Matthieu, Masson, Raphael, Matray, Olivier, Mbadi, Aurore, Mechai, Frédéric, Mellon, Guillaume, Merens, Audrey, Meyohas, Marie Caroline, Michon, Adrien, Mootien Yoganaden, Joy, Morquin, David, Mouly, Stéphane, Mrozek, Natacha, Nguyen, Sophie, Nguyen, Yohan, Ogielska, Maja, Oziol, Eric, Page, Bernard, Patrat-Delon, Solène, Patry, Isabelle, Pechinot, André, Picot, Sandrine, Pierrejean, Piroth, Lionel, Plassart, Claire, Plessis, Patrice, Portel, Laurent, Poubeau, Patrice, Poupard, Marie, Prazuck, Thierry, Quaesaet, Luc, Ramanantsoa, Adriatsiferana, Rapp, Christophe, Raskine, Laurent, Raymond, Josette, Revest, Matthieu, Riche, Agnès, Robaday-Voisin, Stéphanie, Robin, Frédéric, Romaszko, Jean-Pierre, Rousseau, Florence, Roux, Anne-Laure, Royer, Cecile, Saada, Matthieu, Salmon, Dominique, Saroufim, Carlo, Schmit, Jean-Luc, Sebire, Manuela, Segonds, Christine, Sivadon-Tardy, Valérie, Soismier, Nathalie, Kerneis, Solen, Son, Olivia, Sunder, Simon, Suy, Florence, Tande, Didier, Tankovic, Jacques, Valin, Nadia, Van Grunderbeeck, Nicolas, Verdon, Renaud, Vergnaud, Michel, Vernet-Garnier, Véronique, Vidal, Magali, Vitrat, Virginie, Vittecoq, Daniel, Vuotto, Fanny, Coordination and statistical analyses, Gorenne, Isabelle, Laouenan, Cédric, Marcault, Estelle, Mentre, France, Pasquet, Blandine, Roy, Carine, Tubiana, S., Varon, E., Biron, C., Ploy, M.-C., Mourvillier, B., Taha, M.-K., Revest, M., Poyart, C., Martin-Blondel, G., Lecuit, M., Cua, E., Pasquet, B., Preau, M., Hoen, B., and Duval, X.

Published
2020
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8. Systematic Review and Meta-Analysis of Sex Differences in Social Contact Patterns and Implications for Tuberculosis Transmission and Control

Author

Horton, Katherine C., Hoey, Anne L., Beraud, Guillaume, Corbett, Elizabeth L., and White, Richard G.

Subjects
Tuberculosis -- Distribution -- Methods -- Health aspects, Sex differences (Biology) -- Health aspects -- Methods, Contact tracing -- Demographic aspects -- Methods -- Health aspects, Public health administration -- Methods -- Health aspects, Company distribution practices, Health
Abstract

Tuberculosis (TB) is the leading infectious cause of death worldwide; there were an estimated 1.3 million deaths during 2017 (1). Approximately 25% of the world's population is infected with Mycobacterium [...]

Published
2020
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9. Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae

Author

Aissa, Nejla, Losniewski, Alain, Henard, Sandrine, Rabaud, Christian, Janssen, Cécile, Pagani, Léonardo, Bland, Stéphane, Gaillat, Jacques, Bru, Jean Pierre, Bonnin, Pierre, Clavère, Gaelle, Vitrat, Virginie, Maulin, Laurence, Quarsaet, Luc, Roger, Helene, Euzen, Jean-Baptiste, Denes, Eric, Couve-Daecon, Elodie, Lechiche, Catherine, Lavigne, Jean-Philippe, Mondain, Véronique, Pulcini, Celine, Garnier, Veronique, Lambert, Dorothée, Hentzien, Maxime, Nguyen, Yohan, Talarmin, Jean Paul, Rameau, Pascaline, Geffroy, Françoise, Salmon-Rousseau, Arnaud, Cattoir, Vincent, Froissart, Antoine, Aberrane, Said, Legout, Laurence, Roblot, France, Beraud, Guillaume, Pavese, Patricia, Belmonte, Olivier, Traversier, Nicolas, Bellec, Laurent, Lagrange-Xelot, Marie, Moiton, Marie-Pierre, Kuli, Barbara, Longuet, Pascal, Scanvic, Agnes, Colombain, Lea, Ferreyra, Milagros, Jean, Maxime, Eden, Aurelia, Laurens, Etienne, Saada, Matthieu, Aumaitre, Hugues, Malet, Martine, Roustant, Frederique, LeMoing, Vincent, Helene, Jean-Pierre, Theodore, Jonathan, Garandeau, Caroline, Caillon, Jocelyne, Olivero, Benjamin, Boutoille, David, Lepelletier, Didier, Grandière-Perez, Lucia, Beaudron, Aurélie, Ramanantsoa, Céline, Varache, Catherine, Varache, Nicolas, Crochette, Nicolas, Hitoto, Hikombo, Blanchi, Sophie, Penn, Pascale, Louis, Bernard, Vanjak, Dominique, Escande, Marie-Christine, Patrigeon, René-Gilles, Honoré, Stéphanie, Barrelet, Audrey, Amara, Marlène, Galempoix, Jean-Marc, Réveil, Jean-Claude, Bucchiotty, Patricia, Couzigou, Carine, LeMonnier, Alban, Boidin, Emilie, Sire, Stephane, Luizy, Nelly, Bronstain, Caroline, Harbarth, Stephan, Fankhauser, Carolina, Brossier, Caroline, von Dach, Elodie, Sauve, Colette, Adam, Marie-Noelle, Hocqueloux, Laurent, Bret, Laurent, André, Marie-Hélène, Barruet, Régine, Challier, Marion, Cabié, Andre, Roze, Benoit, Plesiat, Patrick, Jeanot, Katy, Patry, Isabelle, Moreau, Joséphine, Chirouze, Catherine, Laurent, Aaron, Bachelier, Marie-Nadège, Kac, Guillaume, Farthouat, Nicolas, Feuillebois, Nicolas, Guimard, Thomas, Bourdon, Sandra, Nguyen, Sophie, Alfandari, Serge, Bentayeb, Houcine, Albertini, Mari-Thérèse, Marchou, Bruno, Gaudré, Noémie, Dubois, Damien, Guillet-Caruba, Christelle, Doucet Populaire, Florence, Fortineau, Nicolas, Escaut, Leila, Lesprit, Philippe, Fihman, Vincent, Gauzit, Rémy, Raymond, Josette, Kerneis, Solene, Leflon-Guibout, Veronique, Lefort, Agnes, Dinh, Aurelien, Roux, Anne-Laure, Abgrall, Sophie, Jauréguy, Françoise, Lucet, Jean-Christophe, Soismier, Nathalie, Lopes, Amanda, Cambau, Emmanuelle, Manceron, Veronique, Barnaud, Guilène, Zahar, Jean-Ralph, Ruckly, Stephane, Hikombo, Hitoto, Bernard, Louis, Timsit, Jean-François, and Brun-Buisson, Christian

Published
2017
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10. Are unknown co-medications, over-the-counter and off-label drug use still problems among people living with HIV? Results from a transversal survey in 23 centres in France.

Author

Tetart, Macha, Passecountrin, Priscila, Lesourd, Anaïs, Sanderink, Diane, Moal, Gwenaël Le, Surgers, Laure, Beraud, Guillaume, Katlama, Christine, Robineau, Olivier, Parienti, Jean-Jacques, and group, the COMEDWEEK Study

Subjects
HIV-positive persons, OFF-label use (Drugs), DRUG interactions, PROTON pump inhibitors, INTEGRASE inhibitors, MULTIHOSPITAL systems
Abstract

Introduction Polypharmacy can lead to drug–drug interactions (DDIs), especially with ART. The burden of co-medications, including over-the-counter (OTC) drugs and self-medications, could be underestimated. We aimed to investigate the proportion of people living with HIV (PLHIV) with declared and undeclared co-medications, as well as their potential burden. Methods We conducted a national, multicentre, 1 week cross-sectional study between 10 December and 16 December 2019 in 23 French hospitals amongst consecutive adult PLHIV presenting for a routine outpatient visit. A standardized questionnaire filled in by the physicians assessed all medications and other active chemical substances taken by the PLHIV. Results Overall we enrolled 496 participants from 23 centres. Median age was 50.6 years; ART regimens included an integrase inhibitor in 61% (n  = 302), an NNRTI in 34% (n  = 169) and a PI in 14% (n  = 70) of the cases. Co-medications involved 392 (79%) PLHIV, among which 85 (17%) received polypharmacy (≥5 medications). Previously unknown co-medications or other active substances were found for 32% (n  = 159) of the participants. Corticosteroids (9%, n  = 46) and proton pump inhibitors (10%, n  = 50) were frequently administered. These co-medications did not differ according to age range. Illegal drug use was declared by 11% (n  = 54) and OTC drugs by 23% (n  = 113) of PLHIV. Potential DDIs were discovered for 11% (n  = 53), leading to treatment modifications in 47% (25/53) of cases. Conclusions Potential DDIs that lead to therapeutic modifications remain significant whatever the age of PLHIV. More devoted time to identify co-medications and OTC treatment is needed in all PLHIV. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Impact of vaccination on the presence and severity of symptoms of hospitalised patients with an infection by the Omicron variant (B.1.1.529) of the SARS-CoV-2 (subvariant BA.1)

Author

Beraud, Guillaume, primary, Bouetard, Laura, additional, Civljak, Rok, additional, Michon, Jocelyn, additional, Tulek, Necla, additional, Lejeune, Sophie, additional, Millot, Romain, additional, Garchet-Beaudron, Aurélie, additional, Lefebvre, Maeva, additional, Velikov, Petar, additional, Festou, Benjamin, additional, Abgrall, Sophie, additional, Lizatovic, Ivan Kresimir, additional, Baldolli, Aurélie, additional, Esmer, Huseyin, additional, Blanchi, Sophie, additional, Froidevaux, Gabrielle, additional, Kapincheva, Nikol, additional, Faucher, Jean-François, additional, Duvnjak, Mario, additional, Afşar, Elçin, additional, Švitek, Luka, additional, Yarimoglu, Saliha, additional, Yarimoglu, Rafet, additional, Janssen, Cécile, additional, and Epaulard, Olivier, additional

Published
2022
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15. ESGAP inventory of target indicators assessing antibiotic prescriptions: a cross-sectional survey

Author

Howard, Philip, Huttner, Benedikt, Beovic, Bojana, Beraud, Guillaume, Kofteridis, Diamantis P., Pano Pardo, José, Schouten, Jeroen, Pulcini, Céline, Angioni, Goffredo, Arvaniti, Kostoula, Barac, Aleksandra, Bolla, Cesare, Calbo, Esther, Dyar, Oliver-James, Fantoni, Massimo, Fjeld, Hilde, Keuleyan, Emma, Kumar, Sathish, Harhxi, Arjan, Jenkins, David, Maurer, Florian P., Messiaen, Peter, Montejo Baranda, Miguel, Muñoz, Patricia, Orlando, Gabriella, Pagani, Leonardo, Pepe, Fatmanur, Gentil, Pilar Retamar, Rocha Pereira, Nuno Miguel, Rodrigues-Bano, Jesus, Skodvin, Brita, Tängden, Thomas, Vitrat, Virginie, Vlahovic-Palcevski, Vera, Wechsler-Fördös, Agnes, and Zarb, Peter

Published
2017
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17. One-Year Sequelae and Quality of Life in Adults with Meningococcal Meningitis: Lessons from the COMBAT Multicentre Prospective Study

Author

Duval, Xavier, Taha, Muhamed-Kheir, Lamaury, Isabelle, Escaut, Lélia, Gueit, Isabelle, Manchon, Pauline, Tubiana, Sarah, Hoen, Bruno, Mourvillier, Bruno, Ploy, Marie-Cécile, Varon, Emmanuelle, Caron, François, Bollaert, Pierre-Edouard, Gaillot, Olivier, Poyart, Claire, Bonacorsi, Stephane, Vandenesch, François, Cambau, Emmanuelle, Lecuit, Marc, Gravet, Alain, Frachet, Bruno, de Broucker, Thomas, Bruhl, Daniel Levy, Raffi, François, Preau, Marie, Anguel, Nadia, Argaud, Laurent, Arista, Sophie, Armand-Lefevre, Laurence, Balavoine, Stéphanie, Baraduc, Régine, Barnaud, Guilène, Beraud, Guillaume, Bernard, Louis, Bernars, Georges, Bertei, Dominique, Bessede, Emilie, Pomares, Typhaine Billard, Biron, Charlotte, Bland, Stéphane, Boileau, Julien, Boubeau, Patrice, Bourdon, Sandra, Bousquet, Aurore, Boyer, Sophie, Bozorg-Grayeli, Alexis, Bret, Laurent, Bretonniere, Cédric, Bricaire, François, Brocas, Elsa, Brun, Michel, Buret, Jennifer, Burucoa, Christophe, Cabalion, Jean, Cabon, Mathieu, Camuset, Guillaume, Canevet, Christophe, Carricajo, Anne, Castan, Bernard, Caumes, Eric, Cazanave, Charles, Chabrol, Amélie, Challan-Belval, Thibaut, Chanteperdrix-Marillier, Vanessa, Chaplain, Chantal, Charlier-Woerther, Caroline, Chaussade, Hélène, Chirouze, Catherine, Clair, Bernard, Colot, Julien, Conil, Jean-Marie, Cordel, Hugues, Cormier, Philippe, Cousson, Joël, Cronier, Pierrick, Cua, Eric, Dao-Dubremetz, Anne, Dargere, Sylvie, Degand, Nicolas, Dekeyser, Sophie, Delaune, Deborah, Denes, Eric, Dequin, Pierre-Francois, Descamps, Diane, Descloux, Elodie, Desmaretz, Jean-Luc, Diehl, Jean-Luc, Dimet, Jérôme, Duval, Aurélien Dinh Xavier, Fabe, Claude, Faibis, Frédéric, Flateau, Clara, Fonsale, Nathalie, Forestier, Emmanuel, Fortineau, Nicolas, Gagneux-Brunon, Amandine, Garandeau, Caroline, Garcia, Magali, Garot, Denis, Gaudry, Stéphane, Goehringer, François, Gregoire-Faucher, Valérie, Grosset, Marine, Gubavu, Camélia, Guelon, Dominique, Guimard, Thomas, Guinard, Jérôme, Hadou, Tahar, Helene, Jean-Pierre, Henard, Sandrine, Henry, Benoit, Hochart, Anne-Cécile, Illes, Gabriela, Jaffuel, Sylvain, Jarrin, Irène, Jaureguy, Françoise, Joseph, Cédric, Juvin, Marie-Emmanuelle, Kayal, Samer, Kerneis, Solen, Lacassin, Flore, Lanotte, Philippe, Laurens, Etienne, Laurichesse, Henri, Le Brun, Cécile, Le Moing, Vincent, Le Turnier, Paul, Lecuyer, Hervé, Ledru, Sylvie, Legrix, Céline, Lemaignen, Adrien, Lemble, Chantal, Lemee, Ludovic, Lesens, Olivier, Levast, Marion, Lhommet, Claire, Males, Silvija, Malpote, Edith, Martin-Blondel, Guillaume, Marx, Matthieu, Masson, Raphael, Matray, Olivier, Mbadi, Aurore, Mechai, Frédéric, Mellon, Guillaume, Merens, Audrey, Meyohas, Marie Caroline, Michon, Adrien, Yoganaden, Joy Mootien, Morquin, David, Mouly, Stéphane, Mrozek, Natacha, Nguyen, Sophie, Nguyen, Yohan, Ogielska, Maja, Oziol, Eric, Page, Bernard, Patrat-Delon, Solène, Patry, Isabelle, Pechinot, André, Picot, Sandrine, Pierrejean, Denys, Piroth, Lionel, Plassart, Claire, Plessis, Patrice, Portel, Laurent, Poubeau, Patrice, Poupard, Marie, Prazuck, Thierry, Quaesaet, Luc, Ramanantsoa, Adriatsiferana, Rapp, Christophe, Raskine, Laurent, Raymond, Josette, Revest, Matthieu, Riche, Agnès, Robaday-Voisin, Stéphanie, Robin, Frédéric, Romaszko, Jean-Pierre, Rousseau, Florence, Roux, Anne-Laure, Royer, Cécile, Saada, Matthieu, Salmon, Dominique, Saroufim, Carlo, Schmit, Jean Luc, Sebire, Manuela, Segonds, Christine, Sivadon-Tardy, Valérie, Soismier, Nathalie, Son, Olivia, Sunder, Simon, Suy, Florence, Tande, Didier, Tankovic, Jacques, Valin, Nadia, van Grunderbeeck, Nicolas, Verdon, Renaud, Vergnaud, Michel, Vernet-Garnier, Véronique, Vidal, Magali, Vitrat, Virginie, Vittecoq, Daniel, Vuotto, Fanny, Gorenne, Isabelle, Laouenan, Cédric, Marcault, Estelle, Mentre, France, Pasquet, Blandine, Roy, Carine, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), Infections Bactériennes Invasives - Invasive Bacterial Infections, Institut Pasteur [Paris] (IP), CHU Pointe-à-Pitre/Abymes [Guadeloupe], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Rouen, Normandie Université (NU), and This study was supported by funding from the Assistance Publique Hopitaux de Paris, the French Society of Infectious Diseases, Pfizer and Sanofi. The rapid service and open access fees were funded by Sanofi.

Subjects
Adult, Community-acquired bacterial meningitis, Adolescent, [SDV]Life Sciences [q-bio], General Medicine, Meningitis, Meningococcal, Meningococcal meningitis, Meningitis, Bacterial, Cohort Studies, Disease Progression, Quality of Life, Humans, Pharmacology (medical), Prospective Studies, France, Long-term follow-up
Abstract

Trial registration: ClinicalTrial.Gov identification number NCT01730690. the COMBAT study group; International audience; Introduction: COMBAT is a prospective, multicentre cohort study that enrolled consecutive adults with community-acquired bacterial meningitis (CABM) in 69 participating centres in France between February 2013 and July 2015 and followed them for 1 year.Methods: Patients aged at least 18 years old, hospitalised with CABM were followed during their hospitalisation and then contacted by phone 12 months after enrolment. Here we present the prevalence of sequelae at 12 months in a subgroup of patients with meningococcal meningitis.Results: Five of the 111 patients with meningococcal meningitis died during initial hospitalisation and two died between discharge and 12 months, leaving 104 patients alive 1 year after enrolment, 71 of whom provided 12-month follow-up data. The median age was 30.0 years and 54.1% of the patients had no identified risk factor for meningitis. More than 30% reported persistent headache, more than 40% were not satisfied with their sleep and 10% had concentration difficulties. Hearing loss was present in about 15% of the patients and more than 30% had depressive symptoms. About 13% of the patients with a previous professional activity had not resumed work. On the SF-12 Health Survey, almost 50% and 30% had physical component or mental component scores lower than the 25th percentile of the score distribution in the French general population. There was a non-significant improvement in the patients' disability scores from hospital discharge to 12 months (p = 0.16), but about 10% of the patients had residual disability.Conclusions: Although most patients in our cohort survive meningococcal meningitis, the long-term burden is substantial and therefore it is important to ensure a prolonged follow-up of survivors and to promote preventive strategies, including vaccination.

Published
2022

18. Survey of delivery of parenteral antimicrobials in non-inpatient settings across Europe

Author

Emilie, Caroline, primary, de Nocker, Phebe, additional, Saïdani, Nadia, additional, Gilchrist, Mark, additional, Seaton, R. Andrew, additional, Patel, Sanjay, additional, Beraud, Guillaume, additional, Kofteridis, Diamantis, additional, Schouten, Jeroen, additional, Thilly, Nathalie, additional, Berrevoets, Marvin, additional, Hulscher, Marlies, additional, Buyle, Franky, additional, and Pulcini, Céline, additional

Published
2022
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20. Symptoms and severity in vaccinated and unvaccinated patients hospitalised with SARS-CoV-2 delta (B.1.617.2) variant infection

Author

Epaulard, Olivier, primary, Abgrall, Sophie, additional, Lefebvre, Maeva, additional, Faucher, Jean-Francois, additional, Michon, Jocelyn, additional, Frentiu, Emilia, additional, Janssen, Cecile, additional, Charbonnier, Gabrielle, additional, Fresse, Audrey, additional, Laurent, Simon, additional, Sandjakian, Lena, additional, Casez, Pierre, additional, Mahamat, Aba, additional, and Beraud, Guillaume, additional

Published
2022
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22. Hydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial

Author

Dubée, Vincent, primary, Roy, Pierre-Marie, additional, Vielle, Bruno, additional, Parot-Schinkel, Elsa, additional, Blanchet, Odile, additional, Darsonval, Astrid, additional, Lefeuvre, Caroline, additional, Abbara, Chadi, additional, Boucher, Sophie, additional, Devaud, Edouard, additional, Robineau, Olivier, additional, Rispal, Patrick, additional, Guimard, Thomas, additional, d’Anglejean, Emma, additional, Diamantis, Sylvain, additional, Custaud, Marc-Antoine, additional, Pellier, Isabelle, additional, Mercat, Alain, additional, Brangier, Antoine, additional, Codron, Philippe, additional, Lemée, Jean Michel, additional, Pichon, Virginie, additional, Dhersin, Robin, additional, Urbanski, Geoffrey, additional, Lavigne, Christian, additional, Courtois, Roxane, additional, Danielou, Hélène, additional, Lebreton, Jonathan, additional, Vatan, Rémi, additional, Crochette, Nicolas, additional, Lainé, Jean-Baptiste, additional, Perez, Lucia, additional, Blanchi, Sophie, additional, Hitoto, Hikombo, additional, Bernard, Louis, additional, Maillot, François, additional, Marchand Adam, Sylvain, additional, Talarmin, Jean-Philippe, additional, Gaigneux, Emeline, additional, Motte-Vincent, Pauline, additional, Morrier, Marine, additional, Merrien, Dominique, additional, Bleher, Yves, additional, Flori, Maxime, additional, Ducet-Boiffard, Amélie, additional, Colin, Orane, additional, Février, Ronan, additional, Thill, Pauline, additional, Tetart, Macha, additional, Demaeght, François, additional, Lafond-Desmurs, Barthelemy, additional, Pradier, Maxime, additional, Meybeck, Agnes, additional, Picaud, Marjorie, additional, Prazuck, Thierry, additional, Chapelet, Guillaume, additional, Rouaud, Agnès, additional, Le Turnier, Paul, additional, Sunder, Simon, additional, Lorleac'h, Aurélien, additional, Dollon, Christophe, additional, Jacquet, Antoine, additional, Le Vely, Francois, additional, Gazeau, Pierre, additional, Ansart, Séverine, additional, Roger, Hélène, additional, Laterza, François, additional, Buzelé, Rodolphe, additional, Tahmi, Fella, additional, Lepeule, Raphael, additional, Lacombe, Karine, additional, Lefebvre, Bénédicte, additional, Célarier, Thomas, additional, Gagneux-Brunon, Amandine, additional, Botelho-Nevers, Elisabeth, additional, Bernard, Marc, additional, Garnier, Camille, additional, Mourguet, Morgane, additional, Pugnet, Gregory, additional, Vienne-Noyes, Sara, additional, Martin-Blondel, Guillaume, additional, Delobel, Pierre, additional, Grouteau, Gaspard, additional, Debard, Alexa, additional, Guilleminault, Laurent, additional, Arias, Pauline, additional, Chakvetadze, Catherine, additional, Flateau, Clara, additional, Kopp, Aude, additional, Putot, Alain, additional, Barben, Jeremy, additional, Mouries Martin, Suzanne, additional, Nuss, Valentine, additional, Piroth, Lionel, additional, Claessens, Yann-Erick, additional, Hentgen, Veronique, additional, Martinot, Martin, additional, Bach-Bunner, Maxime, additional, Bonijoly, Thomas, additional, Gravier, Simon, additional, Michel, Jean-Marc, additional, Andreu, Mathilde, additional, Roriz, Mélanie, additional, Baldolli, Aurélie, additional, Brochard, Julia, additional, Grossi, Olivier, additional, Pineau, Samuel, additional, Brisset, Josselin, additional, Desvaux, Edouard, additional, Gondran, Guillaume, additional, Faucher, Jean-François, additional, Quesnel, Paul-Antoine, additional, Bezanahary, Holy, additional, Danthu, Clément, additional, Gutierrez, Blandine, additional, Ly, Kim, additional, Simonneau, Yannick, additional, Cypierre, Anne, additional, Pinet, Pauline, additional, Durox, Hélène, additional, Ducroix-Roubertou, Sophie, additional, Genet, Claire, additional, Beraud, Guillaume, additional, Le Moal, Gwenael, additional, Rammaert, Blandine, additional, Lanoix, Jean-Philippe, additional, Andrejak, Claire, additional, Joseph, Cédric, additional, Soriot-Thomas, Sandrine, additional, Dhote, Robin, additional, Abad, Sébastien, additional, Benainous, Ruben, additional, Boitiaux, Jean-François, additional, Briend, Guillaume, additional, Gonfroy, Celine, additional, Harent, Stanislas, additional, Lagrange, Aurore, additional, Tone, Alina, additional, Wayenberg, Laura, additional, Desoutter, Sophie, additional, Ettahar, Nicolas, additional, Gey, Thomas, additional, Leroy, Vincent, additional, Gaillard, Sacha, additional, Toma, Andrea, additional, Broussier, Amaury, additional, Etienne, Sandrine, additional, Spivac, Yann, additional, Martha, Benoit, additional, Roch, Nathalie, additional, Diaz, Pierre, additional, N’guyen Baranoff, Danièle, additional, Rebaudet, Stanislas, additional, Jourda, François, additional, Zeller, Valérie, additional, Bienvenu, Boris, additional, Boyer, Arnaud, additional, Briet, Marie, additional, Dubée, Vincent, additional, Guidet, Bertrand, additional, Mismetti, Patrick, additional, Vicaut, Eric, additional, Sanchez, Olivier, additional, Girard, Philippe, additional, Elias, Antoine, additional, Couturaud, Francis, additional, Gable, Béatrice, additional, Lazareff, Sybille, additional, Carballido, Loïc, additional, Hue, Catherine, additional, Chrétien, Jean-Marie, additional, Goraguer, Adrien, additional, and Eeckhoutte, Lucie van, additional

Published
2021
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24. Neurologic manifestations associated with COVID-19: a multicentre registry

Author

Meppiel, Elodie, primary, Peiffer-Smadja, Nathan, additional, Maury, Alexandra, additional, Bekri, Imen, additional, Delorme, Cécile, additional, Desestret, Virginie, additional, Gorza, Lucas, additional, Hautecloque-Raysz, Geoffroy, additional, Landre, Sophie, additional, Lannuzel, Annie, additional, Moulin, Solène, additional, Perrin, Peggy, additional, Petitgas, Paul, additional, SellaI, François, additional, Wang, Adrien, additional, Tattevin, Pierre, additional, de Broucker, Thomas, additional, Abgrall, Sophie, additional, Alby-Laurent, Fanny, additional, Allou, Thibault, additional, Amevigbe, Joséphine, additional, Amarguellay, Hanifa, additional, Alloussi, Nabil, additional, Baille, Guillaume, additional, Barbaz, Mathilde, additional, Bencherif, Lamia, additional, Bensaadi, Samia, additional, Beraud, Guillaume, additional, Bizot, Alexandra, additional, Bottin, Laure, additional, Bruneel, Fabrice, additional, Camdessanche, Jean-Philippe, additional, Chauffier, Jeanne, additional, Csajaghy, Jean-Philippe, additional, De Broucker, Chloé, additional, De Broucker, Thomas, additional, Defebvre, Luc, additional, Dembloque, Elodie, additional, Derache, Nathalie, additional, Dereeper, Olivier, additional, Derollez, Céline, additional, Descotes-Genon, Cécile, additional, Devaux, Mathilde, additional, Dubuc, Lydie, additional, Edan, Gilles, additional, Fickl, Andréa, additional, Fraisse, Thibault, additional, Gugenheim, Michel, additional, Hankiewicz, Karolina, additional, Hansmann, Yves, additional, Henry, Carole, additional, Jobard, Stéphanie, additional, Jouan, Fanny, additional, Kwiatkowski, Arnaud, additional, Lalu, Thibault, additional, Leguilloux, Johan, additional, Lejeune, Camille, additional, Liegeois, Clémence, additional, Mahy, Sophie, additional, Marey, Jonathan, additional, Meppiel, Elodie, additional, Michel, Laure, additional, Mitri, Rita, additional, Moulin, Chloé, additional, Omarjee, Asma, additional, Ozsancak, Canan, additional, Pico, Fernando, additional, Poupard, Marie, additional, Rabier, Valérie, additional, Rizzato, Camille, additional, Roos, Caroline, additional, Saison, Julien, additional, Sayre, Naomi, additional, Sedillot, Nicolas, additional, Sellal, François, additional, Servan, Jérôme, additional, Storey, Caroline, additional, Suchet, Laurent, additional, Tarteret, Paul, additional, Thiebaut, Mathilde, additional, Vaduva, Claudia, additional, Varlan, David, additional, and Zarrouk, Virginie, additional

Published
2021
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26. Prospective Risk Assessment of Medicine Shortages in Europe and Israel: Findings and Implications

Author

Miljković, Nenad, primary, Godman, Brian, additional, Kovačević, Milena, additional, Polidori, Piera, additional, Tzimis, Leonidas, additional, Hoppe-Tichy, Torsten, additional, Saar, Marika, additional, Antofie, Ioan, additional, Horvath, Laszlo, additional, De Rijdt, Thomas, additional, Vida, Róbert György, additional, Kkolou, Elena, additional, Preece, David, additional, Tubić, Biljana, additional, Peppard, Joan, additional, Martinez, Alicia, additional, Yubero, Cristina Garcia, additional, Haddad, Ratiba, additional, Rajinac, Dragana, additional, Zelić, Pavle, additional, Jenzer, Helena, additional, Tartar, Franci, additional, Gitler, Gunda, additional, Jeske, Martina, additional, Davidescu, Michal, additional, Beraud, Guillaume, additional, Kuruc-Poje, Darija, additional, Haag, Kristine Sakstrup, additional, Fischer, Hanne, additional, Sviestina, Inese, additional, Ljubojević, Gordana, additional, Markestad, Anne, additional, Vujić-Aleksić, Vesna, additional, Nežić, Lana, additional, Crkvenčić, Anica, additional, Linnolahti, Johanna, additional, Ašanin, Bogdan, additional, Duborija-Kovačević, Nataša, additional, Bochenek, Tomasz, additional, Huys, Isabelle, additional, and Miljković, Branislava, additional

Published
2020
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29. Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Author

Erdem, Hakan, Ozturk-Engin, Derya, Cag, Yasemin, Senbayrak, Seniha, Inan, Asuman, Kazak, Esra, Savasci, Umit, Elaldi, Nazif, Vahaboglu, Haluk, Hasbun, Rodrigo, Nechifor, Mihai, Tireli, Hulya, Kilicoglu, Gamze, Defres, Sylviane, Gulsun, Serda, Ceran, Nurgul, Crisan, Alexandru, Johansen, Isik Somuncu, Namiduru, Mustafa, Dayan, Saim, Kayabas, Uner, Parlak, Emine, Khalifa, Ahmad, Kursun, Ebru, Sipahi, Oguz Resat, Yemisen, Mucahit, Akbulut, Ayhan, Bitirgen, Mehmet, Popovic, Natasa, Kandemir, Bahar, Luca, Catalina, Parlak, Mehmet, Stahl, Jean Paul, Pehlivanoglu, Filiz, Simeon, Soline, Ulu-Kilic, Aysegul, Yasar, Kadriye, Yilmaz, Gulden, Yilmaz, Emel, Beovic, Bojana, Catroux, Melanie, Lakatos, Botond, Sunbul, Mustafa, Oncul, Oral, Alabay, Selma, Sahin-Horasan, Elif, Kose, Sukran, Shehata, Ghaydaa, Andre, Katell, Dragovac, Gorana, Gul, Hanefi Cem, Karakas, Ahmet, Chadapaud, Stéphane, Hansmann, Yves, Harxhi, Arjan, Kirova, Valerija, Masse-Chabredier, Isabelle, Oncu, Serkan, Sener, Alper, Tekin, Recep, Deveci, Ozcan, Ozkaya, Hacer Deniz, Karabay, Oguz, Agalar, Canan, Gencer, Serap, Karahocagil, Mustafa Kasim, Karsen, Hasan, Kaya, Selcuk, Pekok, Abdullah Umut, Celen, Mustafa Kemal, Deniz, Secil, Ulug, Mehmet, Demirdal, Tuna, Guven, Tumer, Bolukcu, Sibel, Avci, Meltem, Nayman-Alpat, Saygin, Yaşar, Kadriye, Pehlivanoʇlu, Filiz, Ates-Guler, Selma, Mutlu-Yilmaz, Esmeray, Tosun, Selma, Sirmatel, Fatma, Batirel, Ayşe, Öztoprak, Nefise, Kadanali, Ayten, Turgut, Huseyin, Baran, Ali Irfan, Karaahmetoglu, Gokhan, Sunnetcioglu, Mahmut, Haykir-Solay, Asli, Denk, Affan, Ayaz, Celal, Gorenek, Levent, Larsen, Lykke, Poljak, Mario, Barsic, Bruno, Argemi, Xavier, Sørensen, Signe Maj, Bohr, Anne Lisbeth, Tattevin, Pierre, Gunst, Jesper Damsgaard, Baštáková, Lenka, Jereb, Matjaž, Chehri, Mahtab, Beraud, Guillaume, Del Vecchio, Rosa Fontana, Maresca, Mauro, Yilmaz, Hava, Sharif-Yakan, Ahmad, Kanj, Souha Shararah, Korkmaz, Fatime, Komur, Suheyla, Coskuner, Seher Ayten, Ince, Nevin, Akkoyunlu, Yasemin, Halac, Gulistan, Nemli, Salih Atakan, Ak, Oznur, Gunduz, Alper, Gozel, Mustafa G., Hatipoglu, Mustafa, Cicek-Senturk, Gonul, Akcam, Fusun Z., Inkaya, Ahmet C., Sagmak-Tartar, Ayşe, Ersoy, Yasemin, Tuncer-Ertem, Gunay, Balkan, Ilker I., Cetin, Birsen, Ersoz, Gulden, Ozgunes, Nail, Yesilkaya, Aysegul, Erturk, Ayse, Gundes, Sibel, Turhan, Vedat, Yalci, Aysun, Aydin, Emsal, Diktas, Husrev, Ulcay, Asim, Seyman, Derya, Leblebicioglu, Hakan, [Erdem, Hakan -- Savasci, Umit] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Ozturk-Engin, Derya -- Senbayrak, Seniha -- Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Cag, Yasemin] Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kazak, Esra] Uludag Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Vahaboglu, Haluk] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Hasbun, Rodrigo] UT Hlth McGovern Med Sch, Dept Infect Dis, Houston, TX 77030 USA, Kart Yasar, Kadriye -- 0000-0003-2963-4894, Larsen, Lykke -- 0000-0002-4113-4182, VAHABOGLU, Haluk -- 0000-0001-8217-1767, Mikrobiyoloji, OMÜ, Çukurova Üniversitesi, Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Kazak, Esra, AAG-8459-2021, and Ege Üniversitesi

Subjects
0301 basic medicine, Male, Leukocytosis, 0302 clinical medicine, CSF, Encephalitis, Leukocyte, Meningitis, Pleocytosis, Neurosyphilis, Diagnosis, Pathology, Medicine, 030212 general & internal medicine, Brucella meningitis, Middle aged, biology, Meningitis, Pneumococcal, General Medicine, Middle Aged, Central nervous system infection, Tıp, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, medicine.anatomical_structure, Cerebrospinal fluid, Bacterial Meningitides, Cerebrospinal Fluid, Infectious diseases, Protein cerebrospinal fluid level, Pneumococcal, Female, InformationSystems_MISCELLANEOUS, Human, Microbiology (medical), 030106 microbiology, Central nervous system, Brucella, Outcomes, Cerebrospinal fluid pleocytosis, Tuberculous meningitis, Article, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Humans, lcsh:RC109-216, Leukocytosis/cerebrospinal fluid, Herpes simplex encephalitis, business.industry, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Herpetic meningoencephalitis, Central Nervous System Infections/cerebrospinal fluid, Pneumococcal meningitis, Tuberculosis, meningeal, medicine.disease, biology.organism_classification, Meningitis, Pneumococcal/cerebrospinal fluid, ComputingMethodologies_PATTERNRECOGNITION, Tuberculosis, Meningeal/cerebrospinal fluid, Clinical feature, Immunology, business, Central nervous system infections
Abstract

WOS: 000417628500023, PubMed ID: 29081366, Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases., Grant-A-Starr Foundation, Grant-A-Starr Foundation.

Published
2017

30. Management of bloodstream infections by infection specialists: an international ESCMID cross-sectional survey

Author

Diallo, Kévin, primary, Thilly, Nathalie, additional, Luc, Amandine, additional, Beraud, Guillaume, additional, Ergonul, Önder, additional, Giannella, Maddalena, additional, Kofteridis, Diamantis, additional, Kostyanev, Tomislav, additional, Paňo-Pardo, José Ramón, additional, Retamar, Pilar, additional, Kern, Winfried, additional, and Pulcini, Céline, additional

Published
2018
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32. Erratum to ‘Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae’ [International Journal of Antimicrobial Agents 49/1 67–73]

Author

Zahar, Jean-Ralph, primary, Lesprit, Philippe, additional, Ruckly, Stephane, additional, Eden, Aurelia, additional, Hikombo, Hitoto, additional, Bernard, Louis, additional, Harbarth, Stephan, additional, Timsit, Jean-Francois, additional, Brun-Buisson, Christian, additional, Carlet, Jean, additional, Dellamonica, Pierre, additional, Gauzit, Remy, additional, Rabaud, Christian, additional, Zahar, Jean-Ralph, additional, Alfandari, Serge, additional, Cohen, Robert, additional, Coignard, Bruno, additional, Pulcini, Celine, additional, Robert, Jerome, additional, Aissa, Nejla, additional, Losniewski, Alain, additional, Henard, Sandrine, additional, Janssen, Cecile, additional, Pagani, Leonardo, additional, Bland, Stephane, additional, Gaillat, Jacques, additional, Bru, Jean Pierre, additional, Bonnin, Pierre, additional, Clavere, Gaelle, additional, Vitrat, Virginie, additional, Maulin, Laurence, additional, Quarsaet, Luc, additional, Roger, Helene, additional, Euzen, Jean-Baptiste, additional, Denes, Eric, additional, Couve-Daecon, Elodie, additional, Lechiche, Catherine, additional, Lavigne, Jean-Philippe, additional, Mondain, Veronique, additional, Garnier, Veronique, additional, Lambert, Dorothee, additional, Hentzien, Maxime, additional, Nguyen, Yohan, additional, Talarmin, Jean Paul, additional, Rameau, Pascaline, additional, Geffroy, Francoise, additional, Salmon-Rousseau, Arnaud, additional, Cattoir, Vincent, additional, Froissart, Antoine, additional, Aberrane, Said, additional, Legout, Laurence, additional, Roblot, France, additional, Beraud, Guillaume, additional, Pavese, Patricia, additional, Belmonte, Olivier, additional, Traversier, Nicolas, additional, Bellec, Laurent, additional, Lagrange-Xelot, Marie, additional, Moiton, Marie-Pierre, additional, Kuli, Barbara, additional, Longuet, Pascal, additional, Scanvic, Agnes, additional, Colombain, Lea, additional, Ferreyra, Milagros, additional, Jean, Maxime, additional, Laurens, Etienne, additional, Saada, Matthieu, additional, Aumaitre, Hugues, additional, Malet, Martine, additional, Roustant, Frederique, additional, LeMoing, Vincent, additional, Helene, Jean-Pierre, additional, Theodore, Jonathan, additional, Garandeau, Caroline, additional, Caillon, Jocelyne, additional, Olivero, Benjamin, additional, Boutoille, David, additional, Lepelletier, Didier, additional, Grandiere-Perez, Lucia, additional, Beaudron, Aurelie, additional, Ramanantsoa, Celine, additional, Varache, Catherine, additional, Varache, Nicolas, additional, Crochette, Nicolas, additional, Hitoto, Hikombo, additional, Blanchi, Sophie, additional, Penn, Pascale, additional, Louis, Bernard, additional, Vanjak, Dominique, additional, Escande, Marie-Christine, additional, Patrigeon, Rene-Gilles, additional, Honore, Stephanie, additional, Barrelet, Audrey, additional, Amara, Marlene, additional, Galempoix, Jean-Marc, additional, Reveil, Jean-Claude, additional, Bucchiotty, Patricia, additional, Couzigou, Carine, additional, LeMonnier, Alban, additional, Boidin, Emilie, additional, Sire, Stephane, additional, Luizy, Nelly, additional, Bronstain, Caroline, additional, Fankhauser, Carolina, additional, Brossier, Caroline, additional, von Dach, Elodie, additional, Sauve, Colette, additional, Adam, Marie-Noelle, additional, Hocqueloux, Laurent, additional, Bret, Laurent, additional, Andre, Marie-Helene, additional, Barruet, Regine, additional, Challier, Marion, additional, Cabie, Andre, additional, Roze, Benoit, additional, Plesiat, Patrick, additional, Jeanot, Katy, additional, Patry, Isabelle, additional, Moreau, Josephine, additional, Chirouze, Catherine, additional, Laurent, Aaron, additional, Bachelier, Marie-Nadege, additional, Kac, Guillaume, additional, Farthouat, Nicolas, additional, Feuillebois, Nicolas, additional, Guimard, Thomas, additional, Bourdon, Sandra, additional, Nguyen, Sophie, additional, Bentayeb, Houcine, additional, Albertini, Mari-Therese, additional, Marchou, Bruno, additional, Gaudre, Noemie, additional, Dubois, Damien, additional, Guillet-Caruba, Christelle, additional, Populaire, Florence Doucet, additional, Fortineau, Nicolas, additional, Escaut, Leila, additional, Fihman, Vincent, additional, Raymond, Josette, additional, Kerneis, Solene, additional, Leflon-Guibout, Veronique, additional, Lefort, Agnes, additional, Dinh, Aurelien, additional, Roux, Anne-Laure, additional, Abgrall, Sophie, additional, Jaureguy, Francoise, additional, Lucet, Jean-Christophe, additional, Soismier, Nathalie, additional, Lopes, Amanda, additional, Cambau, Emmanuelle, additional, Manceron, Veronique, additional, and Barnaud, Guilene, additional

Published
2017
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33. Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae

Author

Zahar, Jean-Ralph, primary, Lesprit, Philippe, additional, Ruckly, Stephane, additional, Eden, Aurelia, additional, Hikombo, Hitoto, additional, Bernard, Louis, additional, Harbarth, Stephan, additional, Timsit, Jean-François, additional, Brun-Buisson, Christian, additional, Aissa, Nejla, additional, Losniewski, Alain, additional, Henard, Sandrine, additional, Rabaud, Christian, additional, Janssen, Cécile, additional, Pagani, Léonardo, additional, Bland, Stéphane, additional, Gaillat, Jacques, additional, Bru, Jean Pierre, additional, Bonnin, Pierre, additional, Clavère, Gaelle, additional, Vitrat, Virginie, additional, Maulin, Laurence, additional, Quarsaet, Luc, additional, Roger, Helene, additional, Euzen, Jean-Baptiste, additional, Denes, Eric, additional, Couve-Daecon, Elodie, additional, Lechiche, Catherine, additional, Lavigne, Jean-Philippe, additional, Mondain, Véronique, additional, Pulcini, Celine, additional, Garnier, Veronique, additional, Lambert, Dorothée, additional, Hentzien, Maxime, additional, Nguyen, Yohan, additional, Talarmin, Jean Paul, additional, Rameau, Pascaline, additional, Geffroy, Françoise, additional, Salmon-Rousseau, Arnaud, additional, Cattoir, Vincent, additional, Froissart, Antoine, additional, Aberrane, Said, additional, Legout, Laurence, additional, Roblot, France, additional, Beraud, Guillaume, additional, Pavese, Patricia, additional, Belmonte, Olivier, additional, Traversier, Nicolas, additional, Bellec, Laurent, additional, Lagrange-Xelot, Marie, additional, Moiton, Marie-Pierre, additional, Kuli, Barbara, additional, Longuet, Pascal, additional, Scanvic, Agnes, additional, Colombain, Lea, additional, Ferreyra, Milagros, additional, Jean, Maxime, additional, Laurens, Etienne, additional, Saada, Matthieu, additional, Aumaitre, Hugues, additional, Malet, Martine, additional, Roustant, Frederique, additional, LeMoing, Vincent, additional, Helene, Jean-Pierre, additional, Theodore, Jonathan, additional, Garandeau, Caroline, additional, Caillon, Jocelyne, additional, Olivero, Benjamin, additional, Boutoille, David, additional, Lepelletier, Didier, additional, Grandière-Perez, Lucia, additional, Beaudron, Aurélie, additional, Ramanantsoa, Céline, additional, Varache, Catherine, additional, Varache, Nicolas, additional, Crochette, Nicolas, additional, Hitoto, Hikombo, additional, Blanchi, Sophie, additional, Penn, Pascale, additional, Louis, Bernard, additional, Vanjak, Dominique, additional, Escande, Marie-Christine, additional, Patrigeon, René-Gilles, additional, Honoré, Stéphanie, additional, Barrelet, Audrey, additional, Amara, Marlène, additional, Galempoix, Jean-Marc, additional, Réveil, Jean-Claude, additional, Bucchiotty, Patricia, additional, Couzigou, Carine, additional, LeMonnier, Alban, additional, Boidin, Emilie, additional, Sire, Stephane, additional, Luizy, Nelly, additional, Bronstain, Caroline, additional, Fankhauser, Carolina, additional, Brossier, Caroline, additional, von Dach, Elodie, additional, Sauve, Colette, additional, Adam, Marie-Noelle, additional, Hocqueloux, Laurent, additional, Bret, Laurent, additional, André, Marie-Hélène, additional, Barruet, Régine, additional, Challier, Marion, additional, Cabié, Andre, additional, Roze, Benoit, additional, Plesiat, Patrick, additional, Jeanot, Katy, additional, Patry, Isabelle, additional, Moreau, Joséphine, additional, Chirouze, Catherine, additional, Laurent, Aaron, additional, Bachelier, Marie-Nadège, additional, Kac, Guillaume, additional, Farthouat, Nicolas, additional, Feuillebois, Nicolas, additional, Guimard, Thomas, additional, Bourdon, Sandra, additional, Nguyen, Sophie, additional, Alfandari, Serge, additional, Bentayeb, Houcine, additional, Albertini, Mari-Thérèse, additional, Marchou, Bruno, additional, Gaudré, Noémie, additional, Dubois, Damien, additional, Guillet-Caruba, Christelle, additional, Doucet Populaire, Florence, additional, Fortineau, Nicolas, additional, Escaut, Leila, additional, Fihman, Vincent, additional, Gauzit, Rémy, additional, Raymond, Josette, additional, Kerneis, Solene, additional, Leflon-Guibout, Veronique, additional, Lefort, Agnes, additional, Dinh, Aurelien, additional, Roux, Anne-Laure, additional, Abgrall, Sophie, additional, Jauréguy, Françoise, additional, Lucet, Jean-Christophe, additional, Soismier, Nathalie, additional, Lopes, Amanda, additional, Cambau, Emmanuelle, additional, Manceron, Veronique, additional, and Barnaud, Guilène, additional

Published
2017
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34. Results of a multinational study suggests rapid diagnosis and early onset of antiviral treatment in herpetic meningoencephalitis

Author

Erdem, Hakan, Cag, Yasemin, Ozturk-Engin, Derya, Defres, Sylviane, Kaya, Selcuk, Larsen, Lykke, Poljak, Mario, Barsic, Bruno, Argemi, Xavier, Sørensen, Signe Maj, Bohr, Anne Lisbeth, Tattevin, Pierre, Gunst, Jesper Damsgaard, Baštáková, Lenka, Jereb, Matjaž, Somuncu Johansen, Isik, Karabay, Oguz, Pekok, Abdullah Umut, Sipahi, Oguz Resat, Chehri, Mahtab, Beraud, Guillaume, Shehata, Ghaydaa, Fontana del Vecchio, Rosa, Maresca, Mauro, Karsen, Hasan, Sengoz, Gonul, Sunbul, Mustafa, Yilmaz, Gulden, Yilmaz, Hava, Sharif-Yakan, Ahmad, Kanj, Souha, Parlak, Emine, Pehlivanoglu, Filiz, Korkmaz, Fatime, Komur, Suheyla, Kose, Sukran, Ulug, Mehmet, Bolukcu, Sibel, Coskuner, Seher Ayten, Ince, Nevin, Akkoyunlu, Yasemin, Halac, Gulistan, Sahin-Horasan, Elif, Tireli, Hulya, Kilicoglu, Gamze, Al-Mahdawi, Akram, Nemli, Salih Atakan, Inan, Asuman, Senbayrak, Seniha, Stahl, Jean Paul, Vahaboglu, Haluk, Institute of Microbiology and Immunology, Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Fonction, structure et inactivation d'ARN bactériens, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institute of Microbiology and Immunology - Inštitut za mikrobiologijo in imunologijo [Ljubljana, Slovenia], and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Abstract

International audience; Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.

Published
2015

37. Computed tomography assessment of response to treatment in chronic pulmonary aspergillosis

Author

Godet, Cendrine, primary, Laurent, François, additional, Bergeron, Anne, additional, Begeilman, Catherine, additional, Pison, Christophe, additional, Cottin, Vincent, additional, Germaud, Patrick, additional, Philippe, Bruno, additional, Camara, Boubou, additional, Toper, Cécile, additional, Beraud, Guillaume, additional, Roblot, France, additional, and Cadranel, Jacques, additional

Published
2015
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39. Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis

Author

Erdem, Hakan, primary, Cag, Yasemin, additional, Ozturk-Engin, Derya, additional, Defres, Sylviane, additional, Kaya, Selcuk, additional, Larsen, Lykke, additional, Poljak, Mario, additional, Barsic, Bruno, additional, Argemi, Xavier, additional, Sørensen, Signe Maj, additional, Bohr, Anne Lisbeth, additional, Tattevin, Pierre, additional, Gunst, Jesper Damsgaard, additional, Baštáková, Lenka, additional, Jereb, Matjaž, additional, Johansen, Isik Somuncu, additional, Karabay, Oguz, additional, Pekok, Abdullah Umut, additional, Sipahi, Oguz Resat, additional, Chehri, Mahtab, additional, Beraud, Guillaume, additional, Shehata, Ghaydaa, additional, Del Vecchio, Rosa Fontana, additional, Maresca, Mauro, additional, Karsen, Hasan, additional, Sengoz, Gonul, additional, Sunbul, Mustafa, additional, Yilmaz, Gulden, additional, Yilmaz, Hava, additional, Sharif-Yakan, Ahmad, additional, Kanj, Souha Shararah, additional, Parlak, Emine, additional, Pehlivanoglu, Filiz, additional, Korkmaz, Fatime, additional, Komur, Suheyla, additional, Kose, Sukran, additional, Ulug, Mehmet, additional, Bolukcu, Sibel, additional, Coskuner, Seher Ayten, additional, Ince, Nevin, additional, Akkoyunlu, Yasemin, additional, Halac, Gulistan, additional, Sahin-Horasan, Elif, additional, Tireli, Hulya, additional, Kilicoglu, Gamze, additional, Al-Mahdawi, Akram, additional, Nemli, Salih Atakan, additional, Inan, Asuman, additional, Senbayrak, Seniha, additional, Stahl, Jean Paul, additional, and Vahaboglu, Haluk, additional

Published
2015
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41. Erratum to ‘Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae’ [International Journal of Antimicrobial Agents 49/1 67–73]

Author

Brun-Buisson, Christian, Carlet, Jean, Dellamonica, Pierre, Gauzit, Remy, Rabaud, Christian, Zahar, Jean-Ralph, Timsit, Jean-Francois, Alfandari, Serge, Cohen, Robert, Coignard, Bruno, Pulcini, Celine, Robert, Jerome, Aissa, Nejla, Losniewski, Alain, Henard, Sandrine, Janssen, Cecile, Pagani, Leonardo, Bland, Stephane, Gaillat, Jacques, Bru, Jean Pierre, Bonnin, Pierre, Clavere, Gaelle, Vitrat, Virginie, Maulin, Laurence, Quarsaet, Luc, Roger, Helene, Euzen, Jean-Baptiste, Denes, Eric, Couve-Daecon, Elodie, Lechiche, Catherine, Lavigne, Jean-Philippe, Mondain, Veronique, Garnier, Veronique, Lambert, Dorothee, Hentzien, Maxime, Nguyen, Yohan, Talarmin, Jean Paul, Rameau, Pascaline, Geffroy, Francoise, Salmon-Rousseau, Arnaud, Cattoir, Vincent, Froissart, Antoine, Aberrane, Said, Legout, Laurence, Roblot, France, Beraud, Guillaume, Pavese, Patricia, Belmonte, Olivier, Traversier, Nicolas, Bellec, Laurent, Lagrange-Xelot, Marie, Moiton, Marie-Pierre, Kuli, Barbara, Longuet, Pascal, Scanvic, Agnes, Colombain, Lea, Ferreyra, Milagros, Jean, Maxime, Eden, Aurelia, Laurens, Etienne, Saada, Matthieu, Aumaitre, Hugues, Malet, Martine, Roustant, Frederique, LeMoing, Vincent, Helene, Jean-Pierre, Theodore, Jonathan, Garandeau, Caroline, Caillon, Jocelyne, Olivero, Benjamin, Boutoille, David, Lepelletier, Didier, Grandiere-Perez, Lucia, Beaudron, Aurelie, Ramanantsoa, Celine, Varache, Catherine, Varache, Nicolas, Crochette, Nicolas, Hitoto, Hikombo, Blanchi, Sophie, Penn, Pascale, Louis, Bernard, Vanjak, Dominique, Escande, Marie-Christine, Patrigeon, Rene-Gilles, Honore, Stephanie, Barrelet, Audrey, Amara, Marlene, Galempoix, Jean-Marc, Reveil, Jean-Claude, Bucchiotty, Patricia, Couzigou, Carine, LeMonnier, Alban, Boidin, Emilie, Sire, Stephane, Luizy, Nelly, Bronstain, Caroline, Harbarth, Stephan, Fankhauser, Carolina, Brossier, Caroline, von Dach, Elodie, Sauve, Colette, Adam, Marie-Noelle, Hocqueloux, Laurent, Bret, Laurent, Andre, Marie-Helene, Barruet, Regine, Challier, Marion, Cabie, Andre, Roze, Benoit, Plesiat, Patrick, Jeanot, Katy, Patry, Isabelle, Moreau, Josephine, Chirouze, Catherine, Laurent, Aaron, Bachelier, Marie-Nadege, Kac, Guillaume, Farthouat, Nicolas, Feuillebois, Nicolas, Guimard, Thomas, Bourdon, Sandra, Nguyen, Sophie, Bentayeb, Houcine, Albertini, Mari-Therese, Marchou, Bruno, Gaudre, Noemie, Dubois, Damien, Guillet-Caruba, Christelle, Populaire, Florence Doucet, Fortineau, Nicolas, Escaut, Leila, Lesprit, Philippe, Fihman, Vincent, Raymond, Josette, Kerneis, Solene, Leflon-Guibout, Veronique, Lefort, Agnes, Dinh, Aurelien, Roux, Anne-Laure, Abgrall, Sophie, Jaureguy, Francoise, Lucet, Jean-Christophe, Soismier, Nathalie, Lopes, Amanda, Cambau, Emmanuelle, Manceron, Veronique, Barnaud, Guilene, Ruckly, Stephane, Hikombo, Hitoto, and Bernard, Louis

Published
2017
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44. Management of bloodstream infections by infection specialists: an international ESCMID cross-sectional survey

Author

José Ramón Paňo-Pardo, Guillaume Béraud, Céline Pulcini, Esgbis Esgap, Winfried V. Kern, Pilar Retamar, Amandine Luc, Nathalie Thilly, Onder Ergonul, Diamantis P. Kofteridis, Tomislav Kostyanev, Kévin Diallo, Maddalena Giannella, Department of Infective and Tropical Diseases, Dermatology and Internal Medicine [Pointe-à-Pitre, Guadeloupe], CHU Pointe-à-Pitre/Abymes [Guadeloupe], Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Department of Medicine II, University of Freiburg [Freiburg], Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Diallo, Kévin, Thilly, Nathalie, Luc, Amandine, Beraud, Guillaume, Ergonul, Önder, Giannella, Maddalena, Kofteridis, Diamanti, Kostyanev, Tomislav, Paňo-Pardo, José Ramón, Retamar, Pilar, Kern, Winfried, Pulcini, Céline, Koç University, University of Bologna, University of Crete [Heraklion] (UOC), University of Antwerp (UA), Hospital Clínico Universitario 'Lozano Blesa' [Zaragoza, Spain], Hospital Universitario Virgen Macarena [Seville, Spain], ESGAP, and ESGBIS

Subjects
0301 basic medicine, Male, Cross-sectional study, Bacteremia, medicine.disease_cause, Candida albicans, Medicine, Antimicrobial stewardship, Pharmacology (medical), Blood culture, Survey, ComputingMilieux_MISCELLANEOUS, Antibiotic stewardship, biology, medicine.diagnostic_test, Pharmacology. Therapy, Candidiasis, General Medicine, Middle Aged, Staphylococcal Infections, 16. Peace & justice, Antimicrobial, Corpus albicans, 3. Good health, Infectious Diseases, Staphylococcus aureus, Female, Guideline Adherence, Fungemia, Microbiology (medical), Adult, Methicillin-Resistant Staphylococcus aureus, medicine.medical_specialty, 030106 microbiology, Enterococcus faecalis, 03 medical and health sciences, Candidaemia, Internal medicine, Physicians, Humans, Biology, business.industry, Questionnaire, biology.organism_classification, Health Surveys, Cross-Sectional Studies, Bacteraemia, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Human medicine, business
Abstract

Bloodstream infections (BSIs) are common, however international guidelines are available only for methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia and candidaemia. This international ESCMID cross-sectional survey, open from December 2016 to February 2017, explored the management of BSIs by infection specialists. All infection specialists (senior or trainees) giving at least weekly advice on positive blood cultures could participate. Their practices were evaluated using six clinical vignettes presenting uncomplicated BSI cases. A total of 616 professionals from 56 countries participated [333/616 (54%) infectious diseases specialists, 188/616 (31%) clinical microbiologists], of whom 76% (468/616) were members of an antimicrobial stewardship team. Large variations in practice were noted, in particular for the Escherichia coli, Enterococcus faecalis and Pseudomonas aeruginosa vignettes. Echocardiography was considered standard of care by 81% (373/459) of participants for MRSA, 78% (400/510) for methicillin-susceptible S. aureus and 60% (236/395) for Candida albicans. Antimicrobial combination therapy was recommended by 2% (8/360) of respondents for C. albicans, 11% (43/378) for E. coli, 27% (114/420) for MRSA and 39% (155/393) for E. faecalis. Intravenous-to-oral switch was considered in 68% (285/418) for MRSA, 79% (306/388) for E. faecalis, 72% (264/366) for P. aeruginosa and 75% (270/362) for C. albicans. In multivariable analysis, IDSA guideline-compliant practice was more frequent among participants belonging to an antimicrobial stewardship team (aOR = 1.7, P = 0.018 for the MRSA vignette; and aOR = 2.0, P = 0.008 for the candidaemia vignette). This survey showed large variations in practice among infection specialists. International guidelines on management of BSI are urgently needed. (c) 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Published
2018

45. Managing atypical and typical herpetic central nervous system infections: results of a multinational study

Author

Signe Maj Sørensen, Jean-Paul Stahl, Seher Ayten Coskuner, Pierre Tattevin, Mauro Maresca, Sibel Bolukcu, Oğuz Reşat Sipahi, Rosa Fontana, Lykke Larsen, Xavier Argemi, Lenka Baštáková, Guillaume Béraud, Mario Poljak, Gamze Kilicoglu, Matjaž Jereb, Bruno Baršić, Akram Al-Mahdawi, Nevin Ince, Isik Somuncu Johansen, Filiz Pehlivanoglu, Sylviane Defres, Hasan Karsen, Yasemin Akkoyunlu, Asuman Inan, Souha S. Kanj, Hava Yilmaz, Nazif Elaldi, Elif Sahin-Horasan, Jesper Damsgaard Gunst, Emine Parlak, Hulya Tireli, Hakan Erdem, Anne Lisbeth Bohr, Fatime Korkmaz, Oguz Karabay, Haluk Vahaboglu, Gulden Yilmaz, Ghaydaa A. Shehata, Süheyla Kömür, Stephen L. Leib, Mahtab Chehri, Salih Atakan Nemli, Abdullah Umut Pekok, Sukran Kose, Derya Ozturk-Engin, Seniha Senbayrak, Mehmet Ulug, Gulistan Halac, Mustafa Sunbul, Gonul Sengoz, Selçuk Kaya, Ahmad Sharif-Yakan, Yasemin Cag, Institute of Microbiology and Immunology, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Fonction, structure et inactivation d'ARN bactériens, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Universitaire [Grenoble] (CHU), Cumhuriyet Universitesi, AKKOYUNLU, YASEMİN, Institute of Microbiology and Immunology - Inštitut za mikrobiologijo in imunologijo [Ljubljana, Slovenia], Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Ege Üniversitesi, [Cag, Y.] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Erdem, H.] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Leib, S.] Univ Bern, Inst Infect Dis, CH-3012 Bern, Switzerland -- [Defres, S.] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England -- [Defres, S.] Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Trop Infect Dis Unit, Liverpool, Merseyside, England -- [Kaya, S.] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Larsen, L. -- Johansen, I. S.] Odense Univ Hosp, Dept Infect Dis Q, Odense, Denmark -- [Poljak, M.] Univ Ljubljana, Inst Microbiol & Immunol, Fac Med, Ljubljana, Slovenia -- [Ozturk-Engin, D. -- Bolukcu, S. -- Inan, A. -- Senbayrak, S.] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Barsic, B.] Univ Zagreb, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Sch Med, Zagreb, Croatia -- [Argemi, X.] Nouvel Hop Civil, Dept Infect Dis, Strasbourg, France -- [Sorensen, S. M.] Aalborg Univ Hosp, Dept Infect Dis, Aalborg, Denmark -- [Bohr, A. L.] Rigshosp, Copenhagen Univ Hosp, Inst Inflammat Res, Dept Infect Dis & Rheumatol, Copenhagen, Denmark -- [Tattevin, P.] Univ Hosp Pontchaillou, Dept Infect & Trop Dis, Rennes, France -- [Gunst, J. D.] Aarhus Univ Hosp, Dept Infect Dis, Aarhus, Denmark -- [Bastakova, L.] Masaryk Univ, Fac Hosp Brno, Dept Infect Dis, Fac Med, Brno, Czech Republic -- [Jereb, M.] Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia -- [Karabay, O.] Sakarya Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Sakarya, Turkey -- [Pekok, A. U.] Private Erzurum Sifa Hosp, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Sipahi, O. R.] Ege Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Izmir, Turkey -- [Chehri, M.] Hvidovre Univ Hosp, Dept Infect Dis, Copenhagen, Denmark -- [Beraud, G.] Univ Poitiers Hosp, Dept Infect Dis, Poitiers, France -- [Shehata, G.] Assiut Univ Hosp, Dept Neurol & Psychiat, Assiut, Egypt -- [Fontana, R. -- Maresca, M.] Univ Catania, Infect Dis Sect, Dept Clin & Mol Biomed, Catania, Italy -- [Karsen, H.] Harran Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sanliurfa, Turkey -- [Sengoz, G. -- Pehlivanoglu, F.] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sunbul, M. -- Yilmaz, H.] Ondokuz Mayis Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Samsun, Turkey -- [Yilmaz, G.] Ankara Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Sharif-Yakan, A. -- Kanj, S.] Amer Univ Beirut, Med Ctr, Beirut, Lebanon -- [Parlak, E.] Ataturk Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Korkmaz, F.] Konya Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Konya, Turkey -- [Komur, S.] Cukurova Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Kose, S.] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Ulug, M.] Private Umit Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Coskuner, S. A.] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Stahl, J. P.] Univ Grenoble 1, Grenoble, France -- [Stahl, J. P.] Univ Hosp Grenoble, Dept Infect Dis, Grenoble, France -- [Ince, N.] Duzce Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Duzce, Turkey -- [Akkoyunlu, Y.] Bezmi Alem Vakif Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Halac, G.] Bezmi Alem Vakif Univ, Sch Med, Dept Neurol, Istanbul, Turkey -- [Sahin-Horasan, E.] Mersin Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Mersin, Turkey -- [Tireli, H.] Haydarpasa Numune Training & Res Hosp, Dept Neurol, Istanbul, Turkey -- [Kilicoglu, G.] Haydarpasa Numune Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Al-Mahdawi, A.] Baghdad Teaching Hosp, Dept Neurol, Baghdad, Iraq -- [Nemli, S. A.] Katip Celebi Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Izmir, Turkey -- [Vahaboglu, H.] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, N.] Cumhuriyet Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Sivas, Turkey, Ghaydaa, Shehata -- 0000-0002-3631-893X, VAHABOGLU, Haluk -- 0000-0001-8217-1767, Kanj, Souha -- 0000-0001-6413-3396, Beraud, Guillaume -- 0000-0002-4705-0916, Gunst, Jesper -- 0000-0002-3787-0259, Stahl, Jean Paul -- 0000-0002-0086-3557, johansen, isik somuncu -- 0000-0002-2189-9823, Larsen, Lykke -- 0000-0002-4113-4182, Karabay, Oguz -- 0000-0003-0502-432X, OMÜ, Cag, Y, Erdem, H, Leib, S, Defres, S, Kaya, S, Larsen, L, Poljak, M, Ozturk-Engin, D, Barsic, B, Argemi, X, Sorensen, SM, Bohr, AL, Tattevin, P, Gunst, JD, Bastakova, L, Jereb, M, Johansen, IS, Karabay, O, Pekok, AU, Sipahi, OR, Chehri, M, Beraud, G, Shehata, G, Fontana, R, Maresca, M, Karsen, H, Sengoz, G, Sunbul, M, Yilmaz, G, Yilmaz, H, Sharif-Yakan, A, Kanj, S, Parlak, E, Pehlivanoglu, F, Korkmaz, F, Komur, S, Kose, S, Ulug, M, Bolukcu, S, Coskuner, SA, Stahl, JP, Ince, N, Akkoyunlu, Y, Halac, G, Sahin-Horasan, E, Tireli, H, Kilicoglu, G, Al-Mahdawi, A, Nemli, SA, Inan, A, Senbayrak, S, Vahaboglu, H, Elaldi, N, Sakarya Üniversitesi/İlahiyat Fakültesi/Temel İslam Bilimleri Bölümü, Kaya, Süleyman, Karabay, Oğuz, and Çukurova Üniversitesi

Subjects
Male, Pathology, [SDV]Life Sciences [q-bio], encephalitis, Electroencephalography, medicine.disease_cause, Polymerase Chain Reaction, 0302 clinical medicine, Cerebrospinal fluid, 030212 general & internal medicine, Cerebrospinal Fluid, Aged, 80 and over, medicine.diagnostic_test, Atypical presentation, Brain, meningitis, General Medicine, Middle Aged, Magnetic Resonance Imaging, 3. Good health, Infectious Diseases, medicine.anatomical_structure, results of a multinational study-, Clinical Microbiology And Infection, cilt.22, ss.568-569, 2016 [Akkoyunlu Y., Çağ Y., -Managing atypical and typical herpetic central nervous system infections], Female, Presentation (obstetrics), Encephalitis, Adult, Microbiology (medical), medicine.medical_specialty, Adolescent, Central nervous system, Microbiology, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Journal Article, Humans, Aged, Retrospective Studies, managing, Diagnostic Tests, Routine, business.industry, Magnetic resonance imaging, medicine.disease, herpes simplex virus, Herpes simplex virus, Concomitant, DNA, Viral, Encephalitis, Herpes Simplex, business, 030217 neurology & neurosurgery
Abstract

WOS: 000379252100027, PubMed ID: 27085724, There have been many studies pertaining to the management of herpetic meningoencephalitis (HME), but the majority of them have focussed on virologically unconfirmed cases or included only small sample sizes. We have conducted a multicentre study aimed at providing management strategies for HME. Overall, 501 adult patients with PCR-proven HME were included retrospectively from 35 referral centres in 10 countries; 496 patients were found to be eligible for the analysis. Cerebrospinal fluid (CSF) analysis using a PCR assay yielded herpes simplex virus (HSV)-1 DNA in 351 patients (70.8%), HSV-2 DNA in 83 patients (16.7%) and undefined HSV DNA type in 62 patients (12.5%). A total of 379 patients (76.4%) had at least one of the specified characteristics of encephalitis, and we placed these patients into the encephalitis presentation group. The remaining 117 patients (23.6%) had none of these findings, and these patients were placed in the nonencephalitis presentation group. Abnormalities suggestive of encephalitis were detected in magnetic resonance imaging (MRI) in 83.9% of the patients and in electroencephalography (EEG) in 91.0% of patients in the encephalitis presentation group. In the nonencephalitis presentation group, MRI and EEG data were suggestive of encephalitis in 33.3 and 61.9% of patients, respectively. However, the concomitant use of MRI and EEG indicated encephalitis in 96.3 and 87.5% of the cases with and without encephalitic clinical presentation, respectively. Considering the subtle nature of HME, CSF HSV PCR, EEG and MRI data should be collected for all patients with a central nervous system infection. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Published
2016

46. [Fibrate-induced increase in serum creatinine levels: two cases].

Author

Décaudin B, Beraud G, Lannoy D, Semjen E, Wierre L, Horrent S, Résibois JP, Azar R, and Odou P

Subjects
Acute Kidney Injury chemically induced, Acute Kidney Injury pathology, Diabetes Mellitus, Type 2 complications, Female, Humans, Hypercholesterolemia complications, Hypercholesterolemia drug therapy, Kidney Function Tests, Middle Aged, Nephritis, Interstitial chemically induced, Nephritis, Interstitial pathology, Clofibric Acid adverse effects, Creatinine blood, Hypolipidemic Agents adverse effects
Published
2005
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