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2. The contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe

Author

Selten, J. P., primary, Di Forti, M., additional, Quattrone, D., additional, Jones, P. B., additional, Jongsma, H. E., additional, Gayer-Anderson, C., additional, Szöke, A., additional, Llorca, P. M., additional, Arango, C., additional, Bernardo, M., additional, Sanjuan, J., additional, Santos, J. L., additional, Arrojo, M., additional, Tarricone, I., additional, Berardi, D., additional, Lasalvia, A., additional, Tosato, S., additional, la Cascia, C., additional, Velthorst, E., additional, van der Ven, E. M. A., additional, de Haan, L., additional, Rutten, B. P., additional, van Os, J., additional, Kirkbride, J. B., additional, Morgan, C. M., additional, Murray, R. M., additional, and Termorshuizen, F., additional

Published
2024
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5. Reparameterizing Litter Decomposition Using a Simplified Monte Carlo Method Improves Litter Decay Simulated by a Microbial Model and Alters Bioenergy Soil Carbon Estimates.

Author

Juice, S. M., Ridgeway, J. R., Hartman, M. D., Parton, W. J., Berardi, D. M., Sulman, B. N., Allen, K. E., and Brzostek, E. R.

Subjects
MONTE Carlo method, CARBON in soils, NITROGEN fixation, NUTRIENT cycles, PLANT litter
Abstract

Litter decomposition determines soil organic matter (SOM) formation and plant‐available nutrient cycles. Therefore, accurate model representation of litter decomposition is critical to improving soil carbon (C) projections of bioenergy feedstocks. Soil C models that simulate microbial physiology (i.e., microbial models) are new to bioenergy agriculture, and their parameterization is often based on small datasets or manual calibration to reach benchmarks. Here, we reparameterized litter decomposition in a microbial soil C model (CORPSE ‐ Carbon, Organisms, Rhizosphere, and Protection in the Soil Environment) using the continental‐scale Long‐term Inter‐site Decomposition Experiment Team (LIDET) dataset which documents decomposition across a range of litter qualities over a decade. We conducted a simplified Monte Carlo simulation that constrained parameter values to reduce computational costs. The LIDET‐derived parameters improved modeled C and nitrogen (N) remaining, decomposition rates, and litter mean residence times as compared to Baseline parameters. We applied the LIDET litter decomposition parameters to a microbial bioenergy model (Fixation and Uptake of Nitrogen – Bioenergy Carbon, Rhizosphere, Organisms, and Protection) to examine soil C estimates generated by Baseline and LIDET parameters. LIDET parameters increased estimated soil C in bioenergy feedstocks, with even greater increases under elevated plant inputs (i.e., by increasing residue, N fertilization). This was due to the integrated effects of plant litter quantity, quality, and agricultural practices (tillage, fertilization). Collectively, we developed a simple framework for using large‐scale datasets to inform the parameterization of microbial models that impacts projections of soil C for bioenergy feedstocks. Plain Language Summary: Decomposition breaks down organic matter like leaves and roots, creating soil organic material and releasing essential nutrients for plant and microbial growth. Soil creation and nutrient release are processes that affect how much carbon is stored in soil. Soil carbon storage in bioenergy agriculture may help create a favorable carbon balance for biofuels, ultimately reducing the rate of climate change. However, environmental decision makers need reliable information about how different bioenergy plants change soil carbon stocks to predict long‐term outcomes of present‐day decisions. These predictions are generated by computer models that mathematically represent ecological processes using observations from field studies. However, some models that include microbial decomposition lack a robust observational and mathematical basis for their representation of decomposition. We used a large‐scale litter decomposition dataset and simplified a statistical simulation that is typically complex and time‐consuming to improve the mathematical basis for litter decomposition in a soil carbon model. We used the improved decomposition representation in a different model that calculates soil carbon in bioenergy agriculture, and found the new representation increased predicted soil carbon in bioenergy feedstocks. Our statistical, data‐based framework can be adopted to help make model predictions more accurate, and environmental management decisions more effective. Key Points: Simplified Monte Carlo method uses constrained parameter sets and extensive dataset to parameterize decomposition in a microbial modelThe new litter decomposition parameters improved carbon and nitrogen decomposition metrics in a process‐based microbial modelApplying the new parameters to bioenergy systems altered modeled soil carbon with variation by plant traits, management, and litter inputs [ABSTRACT FROM AUTHOR]

Published
2024
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6. Emotion dysregulation, impulsivity and anger rumination in borderline personality disorder: the role of amygdala and insula

Author

Mitolo, M., primary, D’Adda, F., additional, Evangelisti, S., additional, Pellegrini, L., additional, Gramegna, L. L., additional, Bianchini, C., additional, Talozzi, L., additional, Manners, D. N., additional, Testa, C., additional, Berardi, D., additional, Lodi, R., additional, Menchetti, M., additional, and Tonon, C., additional

Published
2023
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7. Real-time Pipeline Reconfiguration of P4 Programmable Switches to Efficiently Detect and Mitigate DDoS Attacks

Author

Lopez, D, Montpetit, MJ, Cerroni, W, Di Mauro, M, Borylo, P, AL SADI, A, Savi, M, Berardi, D, Melis, A, Prandini, M, Callegati, F, Al Sadi Amir, Savi Marco, Berardi Davide, Melis Andrea, Prandini Marco, Callegati Franco, Lopez, D, Montpetit, MJ, Cerroni, W, Di Mauro, M, Borylo, P, AL SADI, A, Savi, M, Berardi, D, Melis, A, Prandini, M, Callegati, F, Al Sadi Amir, Savi Marco, Berardi Davide, Melis Andrea, Prandini Marco, and Callegati Franco

Abstract

In this work we demonstrate the integration of P4 enabled switches with high level AI techniques with the aim to improve efficiency and performance of DDoS detection and mitigation. Powerful ML-based strategies are adopted only when a suspicious behaviour is occurring in the network, and its activation is triggered by a coarser-grained and lightweight strategy fully executable in the data plane.

Published
2023

8. E-Services

Author

Ardagna, D., Avenali, A., Baresi, L., Berardi, D., Bianchini, D., Cappiello, C., Comuzzi, M., De Antonellis, V., De Rosa, F., Desideri, D., Francalanci, C., Leporelli, C., Matteucci, G., Maurino, A., Mecella, M., Melchiori, M., Modafferi, S., Mussi, E., Pernici, B., Plebani, P., Presenza, D., and Pernici, Barbara, editor

Published
2006
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11. Differences in patterns of stimulant use and their impact on first-episode psychosis incidence – an analysis of the EUGEI study

Author

Rodríguez-Toscano, E., Alloza, C., Fraguas, D., Durán-Cutilla, M., Roldán, L., Gutiérrez, T. Sánchez, López-Montoya, G., Parellada, M., Moreno, C., Gayer-Anderson, C., Jongsma, H.E., Di Forti, M., Velthorst, E., de Haan, L., Selten, J., Szöke, A., Llorca, P., Tortelli, A., Bobes, J., Tarricone, I., Berardi, D., Ruggeri, M., Lasalvia, A., Ferraro, L., Menezes, P.R., Rutten, B.P., Van Os, J., Jones, P.B., Murray, R.M., Kirkbride, J.B., Morgan, C., Díaz-Caneja, C.M., and Arango, C.

Published
2022
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12. Long-acting injectable antipsychotics: Six-month follow-up of new outpatient treatments in Bologna Community Mental Health Centres

Author

Berardi, L, Antonazzo, I, Piccinni, C, Raschi, E, Forcesi, E, Fioritti, A, Berardi, D, De Ponti, F, Piazza, A, Poluzzi, E, Berardi L., Antonazzo I. C., Piccinni C., Raschi E., Forcesi E., Fioritti A., Berardi D., De Ponti F., Piazza A., Poluzzi E., Berardi, L, Antonazzo, I, Piccinni, C, Raschi, E, Forcesi, E, Fioritti, A, Berardi, D, De Ponti, F, Piazza, A, Poluzzi, E, Berardi L., Antonazzo I. C., Piccinni C., Raschi E., Forcesi E., Fioritti A., Berardi D., De Ponti F., Piazza A., and Poluzzi E.

Abstract

Purpose This study aims to describe factors associated to treatment continuity and psychiatric relapses in patients treated with Long Acting Injectable antipsychotics (LAIs) in Bologna Community Mental Health Centers (CMHCs). Methods New LAI treatments administered between July 1, 2010 and June 30, 2015 in CMHCs were selected. The cohort was followed-up for 6 months; predictors of continuity and psychiatric admissions were investigated by using logistic regression- and Cox- analysis respectively. Results Among the cohort of 1 070 patients, only 222 (21%) continued LAI treatment during the follow-up. LAI continuity was higher with first generation agents (OR: 1.71, 95%CI 1.18–2.49) and in case of previous psychiatric hospitalizations (OR 2.00, 95%CI 1.47–2.74). Incidence of psychiatric hospital admissions showed a sharp reduction in the follow-up compared with 6-month period before initiation (from 458 to 212), and was associated with previous psychiatric hospitalizations (HR 3.20, 95%CI 2.22–4.59), immigration (HR 3.13, 95%CI 1.28–7.69) and LAI discontinuation (HR 1.14, 95%Cl 1.01–1.97). Conclusions Psychiatric hospital admission before LAI initiation was the main predictor both of LAI continuity and hospitalization during the follow-up.

Published
2019

13. Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients: The EU-GEI case-control study

Author

Quattrone, D, Ferraro, L, Tripoli, G, La Cascia, C, Quigley, H, Quattrone, A, Jongsma, HE, Del Peschio, S, Gatto, G, EU-GEI group, Gayer-Anderson, C, Jones, PB, Kirkbride, JB, La Barbera, D, Tarricone, I, Berardi, D, Tosato, S, Lasalvia, A, Szöke, A, Arango, C, Bernardo, M, Bobes, J, Del Ben, CM, Menezes, PR, Llorca, P-M, Santos, JL, Sanjuán, J, Tortelli, A, Velthorst, E, de Haan, L, Rutten, BPF, Lynskey, MT, Freeman, TP, Sham, PC, Cardno, AG, Vassos, E, van Os, J, Morgan, C, Reininghaus, U, Lewis, CM, Murray, RM, Di Forti, M, Adult Psychiatry, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Quattrone, Diego [0000-0002-6051-8309], Apollo - University of Cambridge Repository, Quattrone D., Ferraro L., Tripoli G., La Cascia C., Quigley H., Quattrone A., Jongsma H.E., Del Peschio S., Gatto G., EU-GEI group, Gayer-Anderson C., Jones P.B., Kirkbride J.B., La Barbera D., Tarricone I., Berardi D., Tosato S., Lasalvia A., Szoke A., Arango C., Bernardo M., Bobes J., Del Ben C.M., Menezes P.R., Llorca P.-M., Santos J.L., Sanjuan J., Tortelli A., Velthorst E., De Haan L., Rutten B.P.F., Lynskey M.T., Freeman T.P., Sham P.C., Cardno A.G., Vassos E., Van Os J., Morgan C., Reininghaus U., Lewis C.M., Murray R.M., Di Forti M., RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, MUMC+: MA Psychiatrie (3), RS: MHeNs - R2 - Mental Health, and MUMC+: Hersen en Zenuw Centrum (3)

Subjects
Marijuana Abuse, IMPACT, Poison control, Cannabis use, cannabis-associated psychosis, 0302 clinical medicine, SCHIZOPHRENIA, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, health care economics and organizations, Applied Psychology, RISK, OUTCOMES, biology, Human factors and ergonomics, psychopathology, first episode psychosis, psychotic experiences, symptom dimensions, 3. Good health, Psychiatry and Mental health, Schizophrenia, HEALTH, Psychopathology, Psychosis, medicine.medical_specialty, DISORDERS, education, 03 medical and health sciences, Injury prevention, medicine, Humans, Psychiatry, ABUSE, Settore MED/25 - Psichiatria, SUBSTANCE USE, METAANALYSIS, Cannabis, business.industry, Case-control study, Original Articles, medicine.disease, biology.organism_classification, 030227 psychiatry, psychotic experience, Psychotic Disorders, first episode psychosi, Case-Control Studies, ONSET, Gene-Environment Interaction, business, cannabis-associated psychosi, 030217 neurology & neurosurgery
Abstract

The work was supported by: Clinician Scientist Medical Research Council fellowship (project reference MR/M008436/1) to MDF; the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King’s College Hospital NHS Foundation Trust to DQ; DFG Heisenberg professorship (no. 389624707) to UR. National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). The Brazilian study was funded by the São Paulo Research Foundation under grant number 2012/0417-0., Quattrone, D., Ferraro, L., Tripoli, G., La Cascia, C., Quigley, H., Quattrone, A., Jongsma, H.E., Del Peschio, S., Gatto, G., Gayer-Anderson, C., Jones, P.B., Kirkbride, J.B., La Barbera, D., Tarricone, I., Berardi, D., Tosato, S., Lasalvia, A., Szöke, A., Arango, C., Bernardo, M., Bobes, J., Del Ben, C.M., Menezes, P.R., Llorca, P.-M., Santos, J.L., Sanjuán, J., Tortelli, A., Velthorst, E., De Haan, L., Rutten, B.P.F., Lynskey, M.T., Freeman, T.P., Sham, P.C., Cardno, A.G., Vassos, E., Van Os, J., Morgan, C., Reininghaus, U., Lewis, C.M., Murray, R.M., Di Forti, M.

Published
2020
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14. Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis: results from the EU-GEI case-control study

Author

Jongsma H, Gayer-Anderson C, Tarricone I, Velthorst E, van der Ven E, Quattrone D, di Forti M, Menezes P, Del-Ben C, Arango C, Lasalvia A, Berardi D, La Cascia C, Bobes J, Bernardo M, Sanjuan J, Santos J, Arrojo M, de Haan L, Tortelli A, Szoke A, Murray R, Rutten B, van Os J, Morgan C, Jones P, Kirkbride J, EU-GEI WP2 Group, Jongsma, Hannah E [0000-0001-6346-5903], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Adolescent, Social Determinants of Health, social disadvantage, Communication Barriers, Black People, Health Status Disparities, Middle Aged, White People, Europe, Young Adult, Psychotic Disorders, Case-Control Studies, Discrimination, Ethnic and Racial Minorities, Ethnicity, Odds Ratio, Schizophrenia, Humans, epidemiology, Female, Gene-Environment Interaction
Abstract

BACKGROUND: Ethnic minority groups in Western countries face an increased risk of psychotic disorders. Causes of this long-standing public health inequality remain poorly understood. We investigated whether social disadvantage, linguistic distance and discrimination contributed to these patterns.; METHODS: We used case-control data from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study, carried out in 16 centres in six countries. We recruited 1130 cases and 1497 population-based controls. Our main outcome measure was first-episode ICD-10 psychotic disorder (F20-F33), and exposures were ethnicity (white majority, black, mixed, Asian, North-African, white minority and other), generational status, social disadvantage, linguistic distance and discrimination. Age, sex, paternal age, cannabis use, childhood trauma and parental history of psychosis were included as a priori confounders. Exposures and confounders were added sequentially to multivariable logistic models, following multiple imputation for missing data.; RESULTS: Participants from any ethnic minority background had crude excess odds of psychosis [odds ratio (OR) 2.03, 95% confidence interval (CI) 1.69-2.43], which remained after adjustment for confounders (OR 1.61, 95% CI 1.31-1.98). This was progressively attenuated following further adjustment for social disadvantage (OR 1.52, 95% CI 1.22-1.89) and linguistic distance (OR 1.22, 95% CI 0.95-1.57), a pattern mirrored in several specific ethnic groups. Linguistic distance and social disadvantage had stronger effects for first- and later-generation groups, respectively.; CONCLUSION: Social disadvantage and linguistic distance, two potential markers of sociocultural exclusion, were associated with increased odds of psychotic disorder, and adjusting for these led to equivocal risk between several ethnic minority groups and the white majority.

Published
2021

15. Premorbid Adjustment and IQ in Patients With First-Episode Psychosis: A Multisite Case-Control Study of Their Relationship With Cannabis Use

Author

Ferraro, Laura, La Cascia Caterina, Quattrone, Diego, Sideli, Lucia, Matranga, Domenica, Capuccio, Veronica, Tripoli, Giada, Gayer-Anderson, Charlotte, Morgan, Craig, Sami Musa, B., Sham, Pak, de Haan Lieuwe, Velthorst, Eva, Jongsma Hannah, E., Kirkbride James, B, Rutten Bart, P. F., Richards Alexander, L, Roldan, Laura, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Sanjuan, Julio, Santos Jose Luis, Arrojo, Manuel, Tarricone, Ilaria, Tortelli, Andrea, Szöke, Andrei, Del-Ben Cristina Marta, Selten, Jean-Paul, Lynskey, Michael, Jones Peter, B., Van Os Jim, La Barbera Daniele, Eu-Gei WP2 Group (Amoretti, S., Baudin, G., Beards, S., Berardi, D., Bonetto, C., Cabrera, B., Carracedo, A., Charpeaud, T., Costas, J., Cristofalo, D., Cuadrado, P., Ferchiou, A., Franke, N., Frijda, F., García Bernardo, E., Garcia-Portilla, P., González Peñas, J., González, E., Hubbard, K., Jamain, S., Jiménez-López, E., Lasalvia, A., Leboyer, M., López Montoya, G., Lorente-Rovira, E., Díaz-Caneja, C. M., Marcelino Loureiro, C., Marrazzo, G., Martínez, C., Matteis, M., Messchaart, E., Moltó, M. D., Moreno, C., Juan, N., Olmeda, M. S., Parellada, M., Pignon, B., Rapado, M., Richard, J. -R., Rodríguez Solano, J. J., Rossi Menezes, P., Ruggeri, M., Sáiz, P. A., Sánchez-Gutierrez, T., Sánchez, E., Sartorio, C., Schürhoff, F., Seminerio, F., Shuhama, R., Stilo, S. A., Termorshuizen, F., Tosato, S., Tronche, A. -M., Van Dam, D., Van Der Ven, E. )., Murray Robin, M., Di Forti Marta, Ferraro, Laura, La Cascia, Caterina, Quattrone, Diego, Sideli, Lucia, Matranga, Domenica, Capuccio, Veronica, Tripoli, Giada, Gayer-Anderson, Charlotte, Morgan, Craig, Sami, Musa B, Sham, Pak, de Haan, Lieuwe, Velthorst, Eva, Jongsma, Hannah E, Kirkbride, James B, Rutten, Bart P F, Richards, Alexander L, Roldan, Laura, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Sanjuan, Julio, Santos, Jose Lui, Arrojo, Manuel, Tarricone, Ilaria, Tortelli, Andrea, Szöke, Andrei, Del-Ben, Cristina Marta, Selten, Jean-Paul, Lynskey, Michael, Jones, Peter B, Van Os, Jim, La Barbera, Daniele, Murray, Robin M, Di Forti, Marta, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, APH - Mental Health, MUMC+: MA Psychiatrie (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, and RS: MHeNs - R2 - Mental Health

Subjects
Male, cognition, Intelligence, Comorbidity, SUBSTANCE USE DISORDERS, 0302 clinical medicine, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, Medicine, PREDICTORS, RISK, education, education.field_of_study, biology, Cognition, Middle Aged, Psychosocial Functioning, sociability, Psychiatry and Mental health, Schizophrenia, Female, Marijuana Use, Social Adjustment, MENTAL-HEALTH, Adult, medicine.medical_specialty, Psychosis, Adolescent, Population, 1ST EPISODE, DRUG-USE, preillness, Settore MED/01 - Statistica Medica, Young Adult, 03 medical and health sciences, AGE, Settore M-PSI/08 - Psicologia Clinica, Humans, Cognitive skill, Psychiatry, Settore MED/25 - Psichiatria, business.industry, Case-control study, preillne, biology.organism_classification, medicine.disease, EDUCAÇÃO, 030227 psychiatry, schizophrenia, Psychotic Disorders, Case-Control Studies, ONSET, Cannabis, NEUROCOGNITION, business, marijuana, Neurocognitive, 030217 neurology & neurosurgery, Regular Articles
Abstract

Psychotic patients with a lifetime history of cannabis use generally show better cognitive functioning than other psychotic patients. Some authors suggest that cannabis-using patients may have been less cognitively impaired and less socially withdrawn in their premorbid life. Using a dataset comprising 948 patients with first-episode psychosis (FEP) and 1313 population controls across 6 countries, we examined the extent to which IQ and both early academic (Academic Factor [AF]) and social adjustment (Social Factor [SF]) are related to the lifetime frequency of cannabis use in both patients and controls. We expected a higher IQ and a better premorbid social adjustment in psychotic patients who had ever used cannabis compared to patients without any history of use. We did not expect such differences in controls. In both patients and controls, IQ was 3 points higher among occasional-users than in never-users (mean difference [Mdiff] = 2.9, 95% CI = [1.2, 4.7]). Both cases and control daily-users had lower AF compared to occasional (Mdiff = −0.3, 95% CI = [−0.5; −0.2]) and never-users (Mdiff = −0.4, 95% CI = [−0.6; −0.2]). Finally, patient occasional (Mdiff = 0.3, 95% CI = [0.1; 0.5]) and daily-users (Mdiff = 0.4, 95% CI = [0.2; 0.6]) had better SF than their never-using counterparts. This difference was not present in controls (Fgroup*frequency(2, 2205) = 4.995, P = .007). Our findings suggest that the better premorbid social functioning of FEP with a history of cannabis use may have contributed to their likelihood to begin using cannabis, exposing them to its reported risk-increasing effects for Psychotic Disorders.

Published
2019
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16. Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study

Author

Ajnakina O, Rodriguez V, Quattrone D, di Forti M, Vassos E, Arango C, Berardi D, Bernardo M, Bobes J, de Haan L, Del-Ben C, Gayer-Anderson C, Jongsma H, Lasalvia A, Tosato S, Llorca P, Menezes P, Rutten B, Santos J, Sanjuan J, Selten J, Szoke A, Tarricone I, D'Andrea G, Richards A, Tortelli A, Velthorst E, Jones P, Arrojo Romero M, La Cascia C, Kirkbride J, van Os J, O'Donovan M, Murray R, and EU-GEI WP2 Group

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, lipids (amino acids, peptides, and proteins)
Abstract

Duration of untreated psychosis (DUP) is associated with clinical outcomes in people with a diagnosis of first-episode psychosis (FEP), but factors associated with length of DUP are still poorly understood. Aiming to obtain insights into the possible biological impact on DUP, we report genetic analyses of a large multi-center phenotypically well-defined sample encompassing individuals with a diagnosis of FEP recruited from 6 countries spanning 17 research sites, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. Genetic propensity was measured using polygenic scores for schizophrenia (SZ-PGS), bipolar disorder (BD-PGS), major depressive disorder (MDD-PGS), and intelligence (IQ-PGS), which were calculated based on the results from the most recent genome-wide association meta-analyses. Following imputation for missing data and log transformation of DUP to handle skewedness, the association between DUP and polygenic scores (PGS), adjusting for important confounders, was investigated with multivariable linear regression models. The sample comprised 619 individuals with a diagnosis of FEP disorders with a median age at first contact of 29.0 years (interquartile range [IQR] = 22.0-38.0). The median length of DUP in the sample was 10.1 weeks (IQR = 3.8-30.8). One SD increases in SZ-PGS, BD-PGS, MDD-PGS or IQ-PGS were not significantly associated with the length of DUP. Our results suggest that genetic variation does not contribute to the DUP in patients with a diagnosis of FEP disorders. © Crown copyright 2021.

Published
2021

17. Models for the integration of psychology and primary health care: Towards the concrete construction of primary care psychological treatment?

Author

Aru F. L., Chiri L. R., Menchetti M., Gallingani F., Filugelli L., Antonica M. R., Ciotti E., Fioritti A., Berardi D., Aru F.L., Chiri L.R., Menchetti M., Gallingani F., Filugelli L., Antonica M.R., Ciotti E., Fioritti A., and Berardi D.

Subjects
Health psychology, Stepped care, Collaborative care, education, Integrated care, Primary care
Abstract

This review highlights the need to improve SSN to face adequately the growing mental health care demands. Previous research bearing on the topic show that the integration of different professional skills is necessary to achieve this target. A stepped care model, composed by a low-intensity intervention with high level of specificity, is the proposed tool. The introduction of psychologist in primary care system and in particular «Lo Psicologo nella Casa della Salute» project seems to answer this requirements.

Published
2019

21. The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme

Author

Gayer-Anderson C, Jongsma H, Di Forti M, Quattrone D, Velthorst E, de Haan L, Selten J, Sz?ke A, Llorca P, Tortelli A, Arango C, Bobes J, Bernardo M, Sanju?n J, Santos J, Arrojo M, Parellada M, Tarricone I, Berardi D, Ruggeri M, Lasalvia A, Ferraro L, La Cascia C, La Barbera D, Menezes P, Del-Ben C, Rutten B, van Os J, Jones P, Murray R, Kirkbride J, Morgan C, and EU-GEI WP2 Grp

Subjects
Environment-environment interactions, Incidence, Gene-environment interactions, Case-control, First-episode psychosis, EU-GEI
Abstract

Purpose The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted.

Published
2020

27. A plunge into the river Aniene: how polluted is our water?

Author

Grenni P, Rossi D, Falconi F, Di Lenola M, Ghergo S, Mastroianni D, Alfarone A, Berardi D, Basosi M, Berardi M, Bravo V, Caico O, Ceccarelli F, Cianfoni G, De Angelis S, De Cesaris C, De Mattia A, Dino LS, Lattanzio A, Ledda L, Leoni J, Pellegrino F, Petrone M, Tonni A, Serpa I, Valterio M, and Minicocci E

Subjects
WFD, river pollution, alternanza scuola-lavoro
Abstract

The River Aniene, a left bank tributary of the River Tiber in Central Italy, is almost certainly affected by various industrial and urban sources of pollution, even if information on its characteristics within the city of Rome is poor or limited to a few elements. In order to awaken students from a high school specialized in science (Rocci High School in Passo Corese, in the province of Rieti) to this problem, in the framework of an "Alternanza scuola-lavoro" project conducted by CNR-IRSA, the water quality of the River Aniene was verified at two sampling points inside the city of Rome analysing a number of parameters foreseen in the Italian Decree 152/2006. In particular many physico-chemical parameters plus anions and metals were measured; moreover, some microbiological parameters, both those foreseen in Italian Decree 152/2006 (faecal contamination) and others (such as total microbial number and viability), were evaluated. The results showed widespread faecal contamination of the water sampled. Some values for chemicals were also not in accordance with the good quality water status standards foreseen in the Water Framework Directive (2000/60/EC) of the European Union and in the Italian Decree 152/2006. Among the various geo-genic and human activity elements influencing the water pollution the human ones were the most significant for the bad river water quality.

Published
2019

28. The clinical contexts of psychosomatic medicine. Cross-cultural issues

Author

Tarricone, I, Graef-Calliess, Et, Chaudhry, N, Kastrup, M, Berardi, D, Bhugra, D, Barca, M, Burian, R, Diefenbacher, A, Ferrari, S, Husain, N, Qureshi, A, Schouler-Ocak, M, and Tosato, S

Subjects
Migration, Ethnic minorities, Psychosomatic Medicine, Psychosomatic Medicine, Ethnic minorities, Migration
Published
2019

29. The provision of mental health services to immigrants and refugees in Italy: The barriers and facilitating factors experienced by mental health workers

Author

Griffiths, G., Tarricone, I., Berardi, D., DONEGANI, IVONNE, FIORITTI, ANGELO, Maisto, R., Braca, M., Menchetti, M., TONTI, LORENZA, NOLET, MARIA, Piazza, A., Spigonardo, V., Griffiths, G., Tarricone, I., Berardi, D., Donegani, I., Fioritti, A., Maisto, R., Braca, M., Menchetti, M., Tonti, L., Nolet, M., Piazza, A., and Spigonardo, V.

Subjects
Clinical Psychology, Refugee, Italy, Psychiatry and Mental Health, Mental health worker, Immigrant
Abstract

Objective: To explore the barriers and facilitating factors to the provision of mental health services to immigrants and refugees by exploring the experiences of mental health workers (MHWs.) Method: A qualitative study was performed in May 2013 in a city in the Emilia Romagna region. Participants were recruited using purposive sampling and 14 semi-structured interviews were performed with MHWs. Framework Analysis was used to interpret the data. Results: Five facilitating factors were identified: language skill of patients, involvement of patients' family, specialist cultural psychiatric services, voluntary services and organisation of the mental health system. Five barriers were identified: patients' perceptions, lack of family support, cultural knowledge of MHWs, language skill of MHWs and funding of the mental health system. Conclusions: The barriers and facilitating factors identified reflect findings from research in both European and non-European countries. Nevertheless, the results of this study highlight the fact that a national mental health policy for immigrants and refugees needs to be implemented alongside cultural competence training programmes and specialist cultural psychiatric services.

Published
2017

30. Treated Incidence of Psychotic Disorders in the Multinational EU-GEI Study

Author

Jongsma HE, Gayer-Anderson C, Lasalvia A, Quattrone D, Mulè A, Szöke A, Selten JP, Turner C, Arango C, Tarricone I, Berardi D, Tortelli A, Llorca PM, de Haan L, Bobes J, Bernardo M, Sanjuán J, Santos JL, Arrojo M, Del-Ben CM, Menezes PR, Velthorst E, Murray RM, Rutten BP, Jones PB, van Os J, Morgan C, Kirkbride JB, and European Network of National Schizophrenia Networks Studying Gene-Environment In

Published
2018

32. Occupation and first episode psychosis in Northern Italy: better outcomes for migrants.

Author

Tarricone, I, Morgan, C, Boydell, J, Panigada, S, Morigi, R, Braca, M, Sutti, E, Boldri, P, Di Forti, M, Murray, RM, Berardi, D, Tarricone, I, Morgan, C, Boydell, J, Panigada, S, Morigi, R, Braca, M, Sutti, E, Boldri, P, Di Forti, M, Murray, RM, and Berardi, D

Abstract

AIMS: Many studies show that migrants have a higher incidence of psychosis compared to natives, but the influence of migration on psychosis outcomes is little investigated. We aimed to evaluate the occupational outcomes of a first episode psychosis (FEP) sample in Bologna (Northern Italy). METHODS: An incidence cohort of FEP patients presenting at the Bologna West Community Mental Health Centers between 2002 and 2009 was assessed at the baseline and at 12th month follow-up. Return to school or work was used as occupational outcome. RESULTS: Most of the patients (82.8%) were still in contact at 12 months. Migrants showed significantly higher rate of return to work compared to natives (adjusted OR 4.45, 95% CI 1.55-12.76). CONCLUSIONS: First generation migrants had better occupational outcomes. Further cross-cultural studies are needed to further explain these findings.

Published
2017

42. A012 – CURRENT UTILIZATION OF AEROBIC EXERCISE IN ADULT NEUROLOGICAL REHABILITATION BY CANADIAN PHYSIOTHERAPISTS

Author

Mehta, SP, MacDermid, JC, Butcher, SJ, Pikaluk, BJ, Heynen, NM, Chura, RL, Farthing, JP, Marciniuk, DD, MacKay-Lyons, M, Doyle, L, MacDonald, T, Law, M, Burgos-Martinez, G, Fleet, A, Che, M, MacKenzie, D, Page, S, Boe, S, Woznowski-Vu, A, Preuss, R, Shaw, JA, Connelly, DM, McWilliam, CL, Shaw, J, Sidhu, K, Kearney, C, Keeber, M, McKay, S, Hopkins-Rosseel, D, Bergsma, K, Van Bavel, C, Fricke, M, Swinamer, J, Winn, CS, Tryssenaar, J, Chisholm, BA, Hummelbrunner, JA, Kandler, LS, Jasper, L, Daniels, J, Haennel, RG, Johnson, R, Martin, B, Norman, KE, Booth, R, Chisholm, B, Ellerton, C, Jelley, W, MacPhail, A, Mooney, P, Mori, B, Taipalus, L, Thomas, B, Duval, G, Ghali, S, Nasirian, A, Santillo, G, Yang, XL, Thomas, A, McKinley, P, Kaizer, F, Desveaux, L, Nanavaty, G, Howell, P, Sundar, R, Ryan, J, Verrier, M, Dutton, TL, Langendoen, T, Marshall, J, Coghill, C, Pederson, C, Blechinger, C, Marshall, M, Hamilton, CB, Chesworth, BM, Styles-Tripp, F, Sheps, D, Bury, J, Bouliane, M, Glasgow, R, Otto, D, Luciak-Corea, C, Beaupre, L, Balyk, R, Carson, S, Graham, J, Hopman, W, Parsons, T, Sawant, A, Overend, T, Prasanna, SS, Korner-Bitensky, N, Ahmed, S, O’Donovan, MJ, Driver, H, Randhawa, BK, Farley, BG, Boyd, LA, Henderson, R, Najafi, B, Bansberg, J, Druja, G, Hinch, S, Sikkema, A, Subramanian, SK, LourenÇo, CB, Chilingaryan, G, Sveistrup, H, Levin, MF, King, J, Chamberland, P, Agar, A, Leger, R, Michaels, R, Poitras, R, Rawji, A, Skelton, D, Warren, M, Lavallée, L, LeBlanc, C, McKim, D, Woolnough, A, Cockburn, L, Wango, J, Benuh, E, Cleaver, S, Madill, SJ, Pontbriand-Drolet, S, Prud’homme-Delage, A, Tang, A, Dumoulin, C, Hiemstra, LA, Lafave, M, Kerslake, S, Heard, M, Buchko, G, Mohtadi, N, Auais, M, Eilayyan, O, Mayo, N, Otfinowski, C, Fung, J, Smallhorn, P, Diez, d’Aux N, Shan, He F, Li, L, Ren, Y, Perez, C, Spahija, J, Sadeghi, M, Ebrahimi, S, Maroufi, N, Jamshidi, AA, Chepeha, JC, Magee, DJ, Warren, S, Storey, AST, Brinkman, DM, Bauck, RA, Myrah, AM, Friess, SN, Webber, SC, Taphorn, A, Magnus, CRA, Arnold, CM, Johnston, G, Dal-Bello, Haas V, Basran, J, Krentz, JR, Berardi, D, Brizard, M, Brière, H, Charron, M, Gagnon, I, Tran, T, Kasymjanova, G, Grossman, M, Xenopoulos, T, Jagoe, T, Agulnik, J, Small, D, Kinlin, C, Marlow, T, Donald, LA, Tiessen, S, Cooper, N, Pryse-Phillips, S, Yoshida, K, Teachman, G, Wright, V, Fehlings, D, Young, N, McKeever, P, Parent, EC, Breitkreitz, R, Ladd, J, McIntosh, K, Pauls, D, Urhbach, S, Koppenhaver, S, Alderdice, C, Evans, J, Feldman, S, Robinson, S, White, L, Long, A, McDougall, M, Bonnet, F, Brososky, C, Hopcroft, L, Bester, L, Clement, D, Quigley, A, Sachdeva, M, Rourke, S, Nixon, S, Mendes, P, Robles, P, Mathur, S, Warmington, K, Kennedy, C, Lundon, K, Rozmovits, L, Lineker, S, Shupak, R, Schneider, R, Kennedy, CA, Soever, L, Passalent, L, Katie, Lundon K, Roots, RK, Bainbridge, L, Brown, H, Li, LC, Gillis, K, Augruso, A, Coe, T, O’Neill, A, Radford, L, Gibson, BE, O’Callaghan, L, Bath, B, Janzen, B, Lovo, Grona S, Bourassa, R, Reilly, J, Prendergast, M, Derbyshire, M, Anderson, CM, Friedman, D, Gilbert, G, Lazowski, D, Hurtubise, K, Cote, N, McGlasson, Emery, C, Woodhouse, L, Jones, A, Dickinson, D, Torrance, G, Landry, MD, Murphy, SM, Rivard, LM, Levac, D, Aisen, M, French, EH, Barclay-Goddard, R, Dubouloz, CJ, Schwartz, CE, Jam, B, Manns, PJ, McDonald, A, Ploughman, M, Evans, C, Zhan, J, Stevens, M, Asmundson, Gordon, Yardley, D, Funk, S, Yeung, E, Sinclair, L, Damp, Lowery C, Denehy, L, Ziegler, T, LaRocque, D, Clarke, L, Edge-Hughes, LM, Budiselic, S, Berney, S, Rankin, A, Juricic, M, Peddie, E, Johnson, A, and Seminowicz, DA

Subjects
Innovation in Education, Practice Models and Policy, Divisions, Abstracts, CPA Congress 2012, Proposals, Guest Editorial, Physiotherapy Research: Basic Science through Population Health, Best Practice
Published
2012

43. Adaptation and psychometric evaluation of the Italian version of the depression attitude questionnaire (DAQ)

Author

Sighinolfi, C, NORCINI PALA, A, Casini, F, Haddad, M, Berardi, D, Menchetti, M, NORCINI PALA, ANDREA, Berardi D, Menchetti, M., Sighinolfi, C, NORCINI PALA, A, Casini, F, Haddad, M, Berardi, D, Menchetti, M, NORCINI PALA, ANDREA, Berardi D, and Menchetti, M.

Abstract

Aims. To validate the Italian version of the 'depression attitude questionnaire' (DAQ), to assess its psychometric properties and to evaluate the primary care physicians' (PCPs) opinion and attitude towards depression. Methods. An Italian version of the DAQ was created and then administered to a representative sample of PCPs working in the Emilia-Romagna region. Results. The findings derived from the Italian version of the DAQ indicated a three-factor solution (professional confidence, negative viewpoint and biological stance), broadly similar to previous studies and with acceptable fit indices. Our results showed that the PCPs consider depression as an increasingly important issue for their daily clinical practice. A large majority of them believed in the effectiveness of antidepressants and considered psychopharmacological treatment as appropriate for the PCPs to undertake. However, most PCP respondents thought that psychotherapy should be left to the specialists. Our findings suggest a prevalent orientation to the biochemical aspects of depression and the use of antidepressant treatment. Conclusions. The PCPs' attitude and opinion towards depression is an important aspect of their understanding and response to this common and disabling condition. The Italian version of the DAQ appears to be an appropriate and useful instrument to assist the understanding of the PCPs' views and potential need for further professional development.

Published
2012

45. Aripiprazole Versus Haloperidol in Combination With Clozapine for Treatment-Resistant Schizophrenia in Routine Clinical Care A Randomized, Controlled Trial

Author

Barbui, C, Accordini, S, Nosè, M, Stroup, S, Purgato, M, Girlanda, F, Esposito, E, Veronese, A, Tansella, M, Cipriani, A, CHAT Clozapine Haloperidol Aripiprazole Trial, Study Group, Losavio, T, Percudani, M, Aldini, F, Appino, Mg, Artioli, P, Barale, F, Beneduce, R, Berardi, D, Bertolazzi, G, Biancosino, B, Bisogno, A, Bivi, R, Bogetto, F, Boso, M, Bozzani, A, Bucolo, P, Casale, M, Cascone, L, Ciammella, L, Cicolini, A, Cipresso, G, Colombo, P, Dal Santo, B, De Francesco, M, Di Lorenzo, G, Di Munzio, W, Erlicher, A, Ferrannini, L, Ferrato, F, Ferro, A, Fragomeno, N, Fricchione Parise, V, Frova, M, Gardellin, F, Garzotto, N, Giambartolomei, A, Giupponi, G, Grassi, L, Grazian, N, Grecu, L, Guerrini, G, Laddomada, F, Lazzarin, E, Lintas, C, Malchiodi, F, Malvini, L, Marchiaro, L, Marsilio, A, Mauri, Mc, Mautone, A, Menchetti, M, Migliorini, G, Mollica, M, Moretti, D, Mulè, S, Nicholau, S, Nosè, F, Occhionero, G, Pacilli, Am, Pecchioli, S, Petrosemolo, P, Piantato, E, Piazza, C, Pontarollo, F, Pycha, R, Quartesan, Roberto, Rillosi, L, Risso, F, Rizzo, R, Rocca, P, Roma, S, Rossattini, M, Rossi, G, Sala, A, Santilli, C, Saraò, G, Sarnicola, A, Sartore, F, Scarone, S, Sciarma, Tiziana, Siracusano, A, Strizzolo, S, Targa, G, Tasser, A, Tomasi, R, Travaglini, R, Valentini, C, Ziero, S., Barbui C., Accordini S., Nosè M., Stroup S., Purgato M., Girlanda F., Esposito E., Veronese A., Tansella M., Cipriani A., CHAT (Clozapine Haloperidol Aripiprazole Trial) Study Group […, Losavio T., Percudani M., Aldini F., Appino M.G., Artioli P., Barale F., Beneduce R., Berardi D., Bertolazzi G., Biancosino B., Bisogno A., Bivi R., Bogetto F., Boso M., Bozzani A., Bucolo P., Casale M., Cascone L., Ciammella L., Cicolini A., Cipresso G., Colombo P., Dal Santo B., De Francesco M., Di Lorenzo G., Di Munzio W., Erlicher A., Ferrannini L., Ferrato F., Ferro A., Fragomeno N., Fricchione Parise V., Frova M., Gardellin F., Garzotto N., Giambartolomei A., Giupponi G., Grassi L., Grazian N., Grecu L., Guerrini G., Laddomada F., Lazzarin E., Lintas C., Malchiodi F., Malvini L., Marchiaro L., Marsilio A., Mauri M.C., Mautone A., Menchetti M., Migliorini G., Mollica M., Moretti D., Mulè S., Nicholau S., Nosè F., Occhionero G., Pacilli A.M., Pecchioli S., Petrosemolo P., Piantato E., Piazza C., Pontarollo F., Pycha R., Quartesan R., Rillosi L., Risso F., Rizzo R., Rocca P., Roma S., Rossattini M., Rossi G., Sala A., Santilli C., Saraò G., Sarnicola A., Sartore F., Scarone S., Sciarma T., Siracusano A., Strizzolo S., Targa G., Tasser A., Tomasi R., Travaglini R., Valentini C., and Ziero S. …]

Subjects
Adult, Male, medicine.medical_specialty, antipsychotics, aripiprazole, clozapine, combination strategies, schizophrenia, medicine.drug_class, medicine.medical_treatment, Drug Resistance, Atypical antipsychotic, Quinolones, Piperazines, law.invention, Randomized controlled trial, law, Internal medicine, Brief Psychiatric Rating Scale, medicine, Haloperidol, Humans, Pharmacology (medical), humans, quinolones, drug resistance, brief psychiatric rating scale, antipsychotic agents, drug therapy, combination, haloperidol, piperazines, adult, female, male, Psychiatry, Antipsychotic, Settore MED/25 - Psichiatria, Clozapine, combination, Randomised Controlled Trial, Aripiprazole, ATYPICAL ANTIPSYCHOTICS, TREATMENT RESISTANCE, drug therapy, Psychiatry and Mental health, Tolerability, Treatment-resistant, Schizophrenia, Drug Therapy, Combination, Female, Psychology, Antipsychotic Agents, medicine.drug
Abstract

This multisite study was conducted to compare the efficacy and tolerability of combination treatment with clozapine plus aripiprazole versus combination treatment with clozapine plus haloperidol in patients with schizophrenia who do not have an optimal response to clozapine. Patients continued to take clozapine and were randomly assigned to receive daily augmentation with aripiprazole or haloperidol. Physicians prescribed the allocated treatments according to usual clinical care. Withdrawal from allocated treatment within 3 months was the primary outcome. Secondary outcomes included severity of symptoms on the Brief Psychiatric Rating Scale and antipsychotic subjective tolerability on the Liverpool University Neuroleptic Side Effect Rating Scale. A total of 106 patients with schizophrenia were randomly assigned to treatment. After 3 months, we found no difference in the proportion of patients who discontinued treatment between the aripiprazole and haloperidol groups (13.2% vs 15.1%, P = 0.780). The 3-month change of the Brief Psychiatric Rating Scale total score was similar in the aripiprazole and haloperidol groups (-5.9 vs -4.4 points, P = 0.523), whereas the 3-month decrease of the Liverpool University Neuroleptic Side Effect Rating Scale total score was significantly higher in the aripiprazole group than in the haloperidol group (-7.4 vs -2.0 points, P = 0.006). These results suggest that augmentation of clozapine with aripiprazole offers no benefit with regard to treatment withdrawal and overall symptoms in schizophrenia compared with augmentation with haloperidol. However, an advantage in the perception of adverse effects with aripiprazole treatment may be meaningful for patients.

Published
2011

46. Depression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design

Author

Menchetti, M., Bortolotti, B., Rucci, P., Scocco, P., Bombi, A., Berardi, D., Affatati, V., Alberini, G., Baranzini, F., Bellino, S., Bellomo, A., Blasi, T., Bogetto, F., Bortolaso, P., Callegari, C., Carpiniello, B., Colombini, N., Contu, C., Croci, G., De Salvia, M., Diurni, M., Elisei, S., Ferretti, M., Fiore, P., Fusar-Poli, P., Iuso, S., Lacalamita, A., La Ferla, T., Lia, L., Luciano, C. C., Magnani, M., Manganaro, D., Martinelli, V., Martino, I., Montaguti, M. B., Nespeca, C., Petito, A., Pinna, F., Piselli, M., Politi, P., Quartesan, R., Rella, A., Restaino, F., Rigatelli, M., Sciarini, P., Simoni, E., Succui, M., Tedeschini, E., Todarello, O., Vender, S., Zaccagni, L., Zizza, M., Lullini, G., Pedrini, E., D'Onghia, A., Mazza, M., Papagni, S., Menchetti M., Bortolotti B., Rucci P., Scocco P., Bombi A., Berardi D., and DEPICS Study Group.

Subjects
Research design, Counseling, Male, NEUROPSYCHIATRIC INTERVIEW MINI, Outcome Assessment, Psychological intervention, Personal Satisfaction, law.invention, Study Protocol, STRUCTURED INTERVIEW, Randomized controlled trial, law, lcsh:Psychiatry, Surveys and Questionnaires, Outcome Assessment, Health Care, Medicine, Depression (differential diagnoses), METHODOLOGICAL ASPECTS, OUTCOMES, Depression, Primary care, Combined Modality Therapy, Diagnostic and Statistical Manual of Mental Disorders, Psychiatry and Mental health, Selective serotonin reuptake inhibitors, Treatment Outcome, PSYCHOSOCIAL INTERVENTION, Research Design, Brief, Serotonin Uptake Inhibitors, Antidepressant, Female, Attitude to Health, Selective Serotonin Reuptake Inhibitors, Adult, PROBLEM SOLVING TREATMENT, medicine.medical_specialty, Adolescent, lcsh:RC435-571, DISORDERS, Outcome Assessment (Health Care), Depressive Disorder, Major, Humans, Primary Health Care, Psychiatric Status Rating Scales, Interpersonal Relations, Psychotherapy, Brief, Quality of life (healthcare), QUALITY OF LIFE, MAJOR DEPRESSION, PSYCHOTHERAPY, Psychiatry, Intensive care medicine, Depressive Disorder, Primary Health Care, Serotonin Uptake Inhibitors, Psychotherapy, Depressive Disorder, business.industry, Major, Health Care, Psychotherapy, business
Abstract

Background Depression is a frequently observed and disabling condition in primary care, mainly treated by Primary Care Physicians with antidepressant drugs. Psychological interventions are recommended as first-line treatment by the most authoritative international guidelines but few evidences are available on their efficacy and effectiveness for mild depression. Methods/Design This multi-center randomized controlled trial was conducted in 9 Italian centres with the aim to compare the efficacy of Inter-Personal Counseling, a brief structured psychological intervention, to that of Selective Serotonin Reuptake Inhibitors. Patients with depressive symptoms referred by Primary Care Physicians to psychiatric consultation-liaison services were eligible for the study if they met the DSM-IV criteria for major depression, had a score ≥13 on the 21-item Hamilton Depression Rating Scale, and were at their first or second depressive episode. The primary outcome was remission of depressive symptoms at 2-months, defined as a HDRS score ≤ 7. Secondary outcome measures were improvement in global functioning and recurrence of depressive symptoms at 12-months. Patients who did not respond to Inter-Personal Counseling or Selective Serotonin Reuptake Inhibitors at 2-months received augmentation with the other treatment. Discussion This trial addresses some of the shortcomings of existing trials targeting major depression in primary care by evaluating the comparative efficacy of a brief psychological intervention that could be easily disseminated, by including a sample of patients with mild/moderate depression and by using different outcome measures. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12608000479303

Published
2010

47. Identifying gene-environment interactions in schizophrenia: Contemporary challenges for integrated, large-scale investigations

Author

Van Os, J. Rutten, B.P. Myin-Germeys, I. Delespaul, P. Viechtbauer, W. Van Zelst, C. Bruggeman, R. Reininghaus, U. Morgan, C. Murray, R.M. Di Forti, M. McGuire, P. Valmaggia, L.R. Kempton, M.J. Gayer-Anderson, C. Hubbard, K. Beards, S. Stilo, S.A. Onyejiaka, A. Bourque, F. Modinos, G. Tognin, S. Calem, M. O'Donovan, M.C. Owen, M.J. Holmans, P. Williams, N. Craddock, N. Richards, A. Humphreys, I. Meyer-Lindenberg, A. Leweke, F.M. Tost, H. Akdeniz, C. Rohleder, C. Bumb, J.M. Schwarz, E. Alptekin, K. Üçok, A. Saka, M.C. Atbagoǧlu, E.C. Gülöksüz, S. Gumus-Akay, G. Cihan, B. Karadaǧ, H. Soygür, H. Cankurtaran, E.S. Ulusoy, S. Akdede, B. Binbay, T. Ayer, A. Noyan, H. Karadayi, G. Akturan, E. Ulaş, H. Arango, C. Parellada, M. Bernardo, M. Sanjuán, J. Bobes, J. Arrojo, M. Santos, J.L. Cuadrado, P. Solano, J.J.R. Carracedo, A. Bernardo, E.G. Roldán, L. López, G. Cabrera, B. Cruz, S. Mesa, E.M.D. Pouso, M. Jiménez, E. Sánchez, T. Rapado, M. González, E. Martínez, C. Sánchez, E. Olmeda, M.S. De Haan, L. Velthorst, E. Van Der Gaag, M. Selten, J.-P. Van Dam, D. Van Der Ven, E. Van Der Meer, F. Messchaert, E. Kraan, T. Burger, N. Leboyer, M. Szoke, A. Schürhoff, F. Llorca, P.-M. Jamain, S. Tortelli, A. Frijda, F. Vilain, J. Galliot, A.-M. Baudin, G. Ferchiou, A. Richard, J.-R. Bulzacka, E. Charpeaud, T. Tronche, A.-M. De Hert, M. Van Winkel, R. Decoster, J. Derom, C. Thiery, E. Stefanis, N.C. Sachs, G. Aschauer, H. Lasser, I. Winklbaur, B. Schlögelhofer, M. Riecher-Rössler, A. Borgwardt, S. Walter, A. Harrisberger, F. Smieskova, R. Rapp, C. Ittig, S. Soguel-Dit-Piquard, F. Studerus, E. Klosterkötter, J. Ruhrmann, S. Paruch, J. Julkowski, D. Hilboll, D. Sham, P.C. Cherny, S.S. Chen, E.Y.H. Campbell, D.D. Li, M. Romeo-Casabona, C.M. Cirión, A.E. Mora, A.U. Jones, P. Kirkbride, J. Cannon, M. Rujescu, D. Tarricone, I. Berardi, D. Bonora, E. Seri, M. Marcacci, T. Chiri, L. Chierzi, F. Storbini, V. Braca, M. Minenna, M.G. Donegani, I. Fioritti, A. La Barbera, D. La Cascia, C.E. Mulè, A. Sideli, L. Sartorio, R. Ferraro, L. Tripoli, G. Seminerio, F. Marinaro, A.M. McGorry, P. Nelson, B. Amminger, G.P. Pantelis, C. Menezes, P.R. Del-Ben, C.M. Tenan, S.H.G. Shuhama, R. Ruggeri, M. Tosato, S. Lasalvia, A. Bonetto, C. Ira, E. Nordentoft, M. Krebs, M.-O. Barrantes-Vidal, N. Cristóbal, P. Kwapil, T.R. Brietzke, E. Bressan, R.A. Gadelha, A. Maric, N.P. Andric, S. Mihaljevic, M. Mirjanic, T.

Abstract

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. © 2014 The Author.

Published
2014

48. Moderators of remission with interpersonal counselling or drug treatment in primary care patients with depression: Randomised controlled trial

Author

Menchetti, M., Rucci, P., Bortolotti, B., Bombi, A., Scocco, P., Kraemer, H. C., Berardi, D., Luciano, C., Lia, L., Manganaro, D., Magnani, M., Nespeca, C., Succu, M., Bellino, S., Bogetto, F., Zizza, M., Colombini, N., Rigatelli, M., Simoni, E., Tedeschin, E., Baranzini, F., Bortolaso, P., Callegari, C., Diurni, G. C. M., Vender, S., Martinelli, V., Politi, P., Sciarini, P., Piselli, Massimiliano, Quartesan, Roberto, Bellomo, A., De Salvia, M., Ferretti, M., Iuso, S., Petito, A., Affatati, V., Todarello, O., Carpiniello, B., Contu, C., Pinna, F., M Menchetti, P Rucci, B Bortolotti, A Bombi, P Scocco, HC Kraemer, D Berardi, and DEPICS group

Subjects
Male, Counseling, SYMPTOMS, Outcome Assessment, MAJOR DEPRESSION, ANTIDEPRESSANT MEDICATION, COGNITIVE THERAPY, MENTAL DISORDERS, PROBLEM SOLVING TREATMENT, PSYCHOTHERAPY, PHARMACOTHERAPY, SIZE, LIFE, INTERPERSONAL COUNSELLING, Anxiety, Severity of Illness Index, law.invention, 0302 clinical medicine, Randomized controlled trial, PRIMARY CARE, law, Outcome Assessment, Health Care, Activities of Daily Living, 030212 general & internal medicine, Depression (differential diagnoses), Remission Induction, Smoking, Middle Aged, DEPRESSION, ANTIDEPRESSANTS, Intention to Treat Analysis, Psychiatry and Mental health, Brief, Practice Guidelines as Topic, Serotonin Uptake Inhibitors, Female, Adult, Depressive Disorder, Major, Effect Modifier, Epidemiologic, Humans, Logistic Models, Outcome Assessment (Health Care), Patient Selection, Primary Health Care, Psychiatric Status Rating Scales, Psychotherapy, Brief, Social Adjustment, medicine.symptom, Psychology, Selective Serotonin Reuptake Inhibitors, medicine.medical_specialty, 03 medical and health sciences, Internal medicine, Severity of illness, medicine, Psychiatry, Depressive Disorder, Intention-to-treat analysis, Epidemiologic, Hamilton Rating Scale for Depression, Major, moderator, medicine.disease, Comorbidity, 030227 psychiatry, Clinical trial, Effect Modifier, Health Care, Psychotherapy
Abstract

BackgroundDespite depressive disorders being very common there has been little research to guide primary care physicians on the choice of treatment for patients with mild to moderate depression.AimsTo evaluate the efficacy of interpersonal counselling compared with selective serotonin reuptake inhibitors (SSRIs), in primary care attenders with major depression and to identify moderators of treatment outcome.MethodA randomised controlled trial in nine centres (DEPICS, Australian New Zealand Clinical Trials Registry number: ACTRN12608000479303). The primary outcome was remission of the depressive episode (defined as a Hamilton Rating Scale for Depression score 7 at 2 months). Daily functioning was assessed using the Work and Social Adjustment Scale. Logistic regression models were used to identify moderators of treatment outcome.ResultsThe percentage of patients who achieved remission at 2 months was significantly higher in the interpersonal counselling group compared with the SSRI group (58.7% v. 45.1%, P = 0.021). Five moderators of treatment outcome were found: depression severity, functional impairment, anxiety comorbidity, previous depressive episodes and smoking habit.ConclusionsWe identified some patient characteristics predicting a differential outcome with pharmacological and psychological interventions. Should our results be confirmed in future studies, these characteristics will help clinicians to define criteria for first-line treatment of depression targeted to patients' characteristics.

Published
2014

49. E-Services

Author

Presenza, D, Melchiori, M, Matteucci, G, Desideri, D, De Rosa, F, Berardi, D, Avenali, A, Plebani, P, Pernici, B, Mussi, E, Modafferi, S, Mecella, M, Matteucci, M, Leporati, AO, Francalanci, C, De Antonellis, V, Comuzzi, M, Cappiello, C, Bianchini, D, Baresi, L, Ardagna, D., MAURINO, ANDREA, Pernici, B, Presenza, D, Melchiori, M, Matteucci, G, Desideri, D, De Rosa, F, Berardi, D, Avenali, A, Plebani, P, Mussi, E, Modafferi, S, Mecella, M, Maurino, A, Matteucci, M, Leporati, A, Francalanci, C, De Antonellis, V, Comuzzi, M, Cappiello, C, Bianchini, D, Baresi, L, and Ardagna, D

Subjects
services, ING-INF/05 - SISTEMI DI ELABORAZIONE DELLE INFORMAZIONI
Published
2006

50. Suicidal ideation and suicide attempts in obsessivecompulsive related disorders (OCRDs): A systematic review and meta-analysis.

Author

Pellegrini, L., Fineberg, N., Menchetti, M., Berardi, D., Rucci, P., Maina, G., Rihmer, Z., and Albert, U.

Subjects
ATTEMPTED suicide, SUICIDAL ideation, COMPULSIVE hoarding, MUSCLE dysmorphia, SUICIDE statistics
Abstract

Introduction: Recent systematic reviews show that OCD is at risk of suicide, but less is known about suicidality and other DSM-5 Obsessive-Compulsive Related Disorders (OCRDs). Objectives: The present meta-analysis has the following aims: 1. to calculate the pooled prevalence rates of suicide attempts and current/lifetime suicidal ideation in OCRDs, and 2. to identify predictors of suicide risk. Methods: This systematic review and meta-analysis was performed by searching inMedline from the date of the first available article to Dicember 31, 2018. Meta-analyses of proportions based on randomeffectsDer Simonian and Lairdmethod was used to derive the pooled estimates. Analyses were executed using Stata version 15.1. Results: Concerning suicide attempts in BDD, the pooled prevalence rate is 0.287 (IC95% 0.202-0.372) (figure-1); comorbid OCD, substance use, MDD, poor insight, severity, early onset and muscle dysmorphia raise the risk. Pooled prevalence rates of current/lifetime suicidal ideation are 0.311 (IC95% 0.212-0.410) (subgroup A figure-2) and 0.742 (IC95% 0.694-0.790) (subgroup B figure-2), respectively. Hoarding Disorder has a pooled prevalence rate of suicide attempts of 0.176 (IC 95% 0.117-0.235) (figure-3), while current suicidal ideation is 0.105 (IC95% 0.072-0.137). Suicide attempts in Grooming Disorders (Trichotillomania and Skin Picking Disorder) have a pooled prevalence rate of 0.115 (IC95% 0.054-0.176), current ideation in these disorders is 0.408 (IC95% 0.360-0.455). Conclusions: Our present meta-analysis shows that, like pure OCD, OCRDs are at suicide risk independently from comorbid disorders (specifically independently from comorbid OCD); BDD is the disorder with the highest risk (even higher than OCD), followed by HD and then Grooming Disorders. [ABSTRACT FROM AUTHOR]

Published
2020

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