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3. Ledelse for entreprenørskap i skolen

Author

Bentzen, Trine and Smørholm, Margaret Nybø

Subjects
bedriftsledelse, entreprenørskap, skole, mba, ledelse, Social science: 200::Political science and organizational theory: 240::Public and private administration: 242 [VDP]
Abstract

Master in Business Administration (MBA) - Nord universitet 2019

Published
2019

5. Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma.

Author

Dalen, Knut Tomas, Schoonjans, Kristina, Ulven, Stine M., Weedon-Fekjaer, Mina Susanne, Bentzen, Trine Gjesti, Koutnikova, Hana, Auwerx, Johan, and Nebb, Hilde I.

Subjects
ADIPOSE tissues, LIPIDS, PROTEINS, FATTY acids, FAT cells, PEROXISOMES, TYPE 2 diabetes, OBESITY
Abstract

In a systematic search for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) target genes, we identified S3-12 and perilipin as novel direct PPAR-gamma target genes. Together with adipophilin and tail-interacting protein of 47 kDa, these genes are lipid droplet-associating proteins with distinct expression pattern but overlapping expression in adipose tissue. The expression of S3-12 and perilipin is tightly correlated to the expression and activation of PPAR-gamma in adipocytes, and promoter characterization revealed that the S3-12 and the perilipin promoters contain three and one evolutionarily conserved PPAR response elements, respectively. We furthermore demonstrate that the expression of S3-12 and perilipin is reduced in obese compared with lean Zucker rats, whereas the expression of adipophilin is increased. Others have shown that perilipin is an essential factor in the hormonal regulation of lipolysis of stored triglycerides within adipose tissue. The direct regulation of perilipin and S3-12 by PPAR-gamma therefore is likely to be an important mediator of the in vivo effects of prolonged treatment with PPAR-gamma activators: insulin sensitization, fatty acid trapping in adipose tissue, reduced basal adipose lipolysis, and weight gain. [ABSTRACT FROM AUTHOR]

Published
2004
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6. Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma

Author

Dalen, Knut Tomas, Schoonjans, Kristina, Ulven, Stine M., Weedon-Fekjaer, Mina Susanne, Bentzen, Trine Gjesti, Koutnikova, Hana, Auwerx, Johan, and Nebb, Hilde I.

Abstract

In a systematic search for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) target genes, we identified S3-12 and perilipin as novel direct PPAR-gamma target genes. Together with adipophilin and tail-interacting protein of 47 kDa, these genes are lipid droplet-associating proteins with distinct expression pattern but overlapping expression in adipose tissue. The expression of S3-12 and perilipin is tightly correlated to the expression and activation of PPAR-gamma in adipocytes, and promoter characterization revealed that the S3-12 and the perilipin promoters contain three and one evolutionarily conserved PPAR response elements, respectively. We furthermore demonstrate that the expression of S3-12 and perilipin is reduced in obese compared with lean Zucker rats, whereas the expression of adipophilin is increased. Others have shown that perilipin is an essential factor in the hormonal regulation of lipolysis of stored triglycerides within adipose tissue. The direct regulation of perilipin and S3-12 by PPAR-gamma therefore is likely to be an important mediator of the in vivo effects of prolonged treatment with PPAR-gamma activators: insulin sensitization, fatty acid trapping in adipose tissue, reduced basal adipose lipolysis, and weight gain.

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