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444 results on '"Bentzen, Soren"'

3. Organs at Risk Considerations for Thoracic Stereotactic Body Radiation Therapy: What Is Safe for Lung Parenchyma?

Author

Kong, Feng-Ming Spring, Moiseenko, Vitali, Zhao, Jing, Milano, Michael T, Li, Ling, Rimner, Andreas, Das, Shiva, Li, X Allen, Miften, Moyed, Liao, ZhongXing, Martel, Mary, Bentzen, Soren M, Jackson, Andrew, Grimm, Jimm, Marks, Lawrence B, and Yorke, Ellen

Subjects
Medical and Biological Physics, Biomedical and Clinical Sciences, Clinical Sciences, Physical Sciences, Oncology and Carcinogenesis, Lung, Rare Diseases, Cancer, Lung Cancer, 6.5 Radiotherapy and other non-invasive therapies, Evaluation of treatments and therapeutic interventions, Respiratory, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Models, Biological, Models, Theoretical, Organs at Risk, Pulmonary Fibrosis, Radiation Pneumonitis, Radiation Tolerance, Radiosurgery, Radiotherapy Dosage, Re-Irradiation, Risk Factors, Tumor Burden, Other Physical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Theoretical and computational chemistry, Medical and biological physics
Abstract

PurposeStereotactic body radiation therapy (SBRT) has become the standard of care for inoperable early-stage non-small cell lung cancer and is often used for recurrent lung cancer and pulmonary metastases. Radiation-induced lung toxicity (RILT), including radiation pneumonitis and pulmonary fibrosis, is a major concern for which it is important to understand dosimetric and clinical predictors.Methods and materialsThis study was undertaken through the American Association of Physicists in Medicine's Working Group on Biological Effects of Stereotactic Body Radiotherapy. Data from studies of lung SBRT published through the summer of 2016 that provided detailed information about RILT were analyzed.ResultsNinety-seven studies were ultimately considered. Definitions of the risk organ and complication endpoints as well as dose-volume information presented varied among studies. The risk of RILT, including radiation pneumonitis and pulmonary fibrosis, was reported to be associated with the size and location of the tumor. Patients with interstitial lung disease appear to be especially susceptible to severe RILT. A variety of dosimetric parameters were reported to be associated with RILT. There was no apparent threshold "tolerance dose-volume" level. However, most studies noted safe treatment with a rate of symptomatic RILT of

Published
2021

5. Radiation Fractionation Schedules Published During the COVID-19 Pandemic: A Systematic Review of the Quality of Evidence and Recommendations for Future Development

Author

Thomson, David J, Yom, Sue S, Saeed, Hina, El Naqa, Issam, Ballas, Leslie, Bentzen, Soren M, Chao, Samuel T, Choudhury, Ananya, Coles, Charlotte E, Dover, Laura, Guadagnolo, B Ashleigh, Guckenberger, Matthias, Hoskin, Peter, Jabbour, Salma K, Katz, Matthew S, Mukherjee, Somnath, Rembielak, Agata, Sebag-Montefiore, David, Sher, David J, Terezakis, Stephanie A, Thomas, Toms V, Vogel, Jennifer, and Estes, Christopher

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Mind and Body, Clinical Research, Good Health and Well Being, COVID-19, Coronavirus Infections, Dose Fractionation, Radiation, Evidence-Based Medicine, Humans, Pandemics, Pneumonia, Viral, Publications, Other Physical Sciences, Clinical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Theoretical and computational chemistry, Medical and biological physics
Abstract

PurposeNumerous publications during the COVID-19 pandemic recommended the use of hypofractionated radiation therapy. This project assessed aggregate changes in the quality of the evidence supporting these schedules to establish a comprehensive evidence base for future reference and highlight aspects for future study.Methods and materialsBased on a systematic review of published recommendations related to dose fractionation during the COVID-19 pandemic, 20 expert panelists assigned to 14 disease groups named and graded the highest quality of evidence schedule(s) used routinely for each condition and also graded all COVID-era recommended schedules. The American Society for Radiation Oncology quality of evidence criteria were used to rank the schedules. Process-related statistics and changes in distributions of quality ratings of the highest-rated versus recommended COVID-19 era schedules were described by disease groups and for specific clinical scenarios.ResultsFrom January to May 2020 there were 54 relevant publications, including 233 recommended COVID-19-adapted dose fractionations. For site-specific curative and site-specific palliative schedules, there was a significant shift from established higher-quality evidence to lower-quality evidence and expert opinions for the recommended schedules (P = .022 and P < .001, respectively). For curative-intent schedules, the distribution of quality scores was essentially reversed (highest levels of evidence "pre-COVID" vs "in-COVID": high quality, 51.4% vs 4.8%; expert opinion, 5.6% vs 49.3%), although there was variation in the magnitude of shifts between disease sites and among specific indications.ConclusionsA large number of publications recommended hypofractionated radiation therapy schedules across numerous major disease sites during the COVID-19 pandemic, which were supported by a lower quality of evidence than the highest-quality routinely used dose fractionation schedules. This work provides an evidence-based assessment of these potentially practice-changing recommendations and informs individualized decision-making and counseling of patients. These data could also be used to support radiation therapy practices in the event of second waves or surges of the pandemic in new regions of the world.

Published
2020

7. ESTRO ACROP and SIOPE recommendations for myeloablative Total Body Irradiation in children

Author

Hoeben, Bianca A.W., Pazos, Montserrat, Seravalli, Enrica, Bosman, Mirjam E., Losert, Christoph, Albert, Michael H., Boterberg, Tom, Ospovat, Inna, Mico Milla, Soraya, Demiroz Abakay, Candan, Engellau, Jacob, Jóhannesson, Vilberg, Kos, Gregor, Supiot, Stéphane, Llagostera, Camille, Bierings, Marc, Scarzello, Giovanni, Seiersen, Klaus, Smith, Ed, Ocanto, Abrahams, Ferrer, Carlos, Bentzen, Søren M., Kobyzeva, Daria A., Loginova, Anna A., and Janssens, Geert O.

Published
2022
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9. A phase II trial of reirradiation combined with pembrolizumab in patients with locoregional inoperable recurrence or second primary squamous cell carcinoma of the head and neck (HNSCC).

Author

Zandberg, Dan Paul, primary, Bauman, Jessica R, additional, Mehra, Ranee, additional, Molitoris, Jason K., additional, Jelinek, Mark, additional, Wang, Hong, additional, Clump, David Anthony, additional, Skinner, Heath Devin, additional, Ferris, Robert L., additional, Fenton, Moon Jung, additional, Cullen, Kevin J., additional, Suntharalingam, Mohan, additional, Bentzen, Soren, additional, Giri, Anshu, additional, Liu, Jeffrey C, additional, and Galloway, Thomas James, additional

Published
2024
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16. Epilepsy surgery for children with epileptic spasms: A systematic review and meta‐analysis with focus on predictors and outcomes.

Author

Kolosky, Taylor, Goldstein Shipper, Andrea, Sun, Kai, Tozduman, Busra, Bentzen, Soren, Moosa, Ahsan N., and Erdemir, Gozde

Subjects
CHILD patients, INFANTILE spasms, PEDIATRIC surgery, EPILEPSY surgery, CHILDREN with epilepsy
Abstract

To conduct a systematic review of the literature regarding rates and predictors of favorable seizure outcome after resective surgery for epileptic spasms (ES) in pediatric patients. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses standards were followed. We searched PubMed, EMBASE, and Cochrane CENTRAL for articles published on the prevalence or incidence of epileptic spasm since 1985. Abstract, full‐text review, and data extraction were conducted by two independent reviewers. Meta‐analysis was performed to assess overall seizure freedom rate. Subject‐level analysis was performed on a subset of studies to identify prognostic indicators. A total of 21 retrospective studies (n = 531) were included. Meta‐analysis of all studies demonstrated a pooled seizure freedom rate of 68.8%. Subject‐level analysis on 18 studies (n = 360) demonstrated a significant association between duration of spasms and recurrence of spasms after surgery, with an estimated increased risk of 7% per additional year of spasms prior to operation. Patients who underwent resective surgery that was not a hemispherectomy (i.e., lobectomy, lesionectomy, etc.) had an increased recurrence risk of 57% compared to patients who had undergone hemispherectomy. Resective surgery results in seizure freedom for the majority of pediatric patients with epileptic spasms. Patients who undergo hemispherectomy have lower risk of recurrence than patients who undergo other types of surgical resection. Increased duration of spasms prior to surgery is associated with increased recurrence risk after surgery. Plain Language Summary: Children with epileptic spasms (ES) that do not respond to medications may benefit from surgical treatment. Our study reviewed existing research to understand how effective surgery is in treating ES in children and what factors predict better outcomes. Researchers followed strict guidelines to search for and analyze studies published since 1985, finding 21 studies with a total of 531 patients. They found that, on average, nearly 70% of children became seizure‐free after surgery. Further individual analysis of 360 patients showed that longer duration of spasms before surgery increased the risk of spasms returning by 7% per year. Additionally, children who had less extensive surgeries, such as removal of only a specific part of the brain, had a 57% higher risk of seizure recurrence compared to those who had a hemispherectomy, which removed or disconnected half of the brain. Overall, the study concludes that surgery can often stop seizures, especially when more extensive surgery is performed and when the surgery is done sooner rather than later. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Multiple HPV infections among men who have sex with men engaged in anal cancer screening in Abuja, Nigeria

Author

Charurat, Manhattan, Ake, Julie, Abayomi, Aka, Adebajo, Sylvia, Baral, Stefan, Crowell, Trevor, Gaydos, Charlotte, Ketende, Sosthenes, Kokogho, Afoke, Malia, Jennifer, Makanjuola, Olumide, Michael, Nelson, Ndemb, Nicaise, Nowak, Rebecca, Olawore, Oluwasolape, Parker, Zahra, Peel, Sheila, Ramadhani, Habib, Robb, Merlin, Rodriguez-Hart, Cristina, Sanders-Buell, Eric, Shoyemi, Elizabeth, Tovanabutra, Sodsai, Vasan, Sandhya, Nowak, Rebecca G., Schumaker, Lisa M., Ambulos, Nicholas P., Ndembi, Nicaise, Dauda, Wuese, Nnaji, Chinedu H., Mitchell, Andrew, Mathias, Trevor J., Jibrin, Paul, Darragh, Teresa M., Olaomi, Oluwole, Crowell, Trevor A., Baral, Stefan D., Charurat, Manhattan E., Bentzen, Søren M., Palefsky, Joel M., and Cullen, Kevin J.

Published
2020
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25. Methodological Comparison of Mapping the Expanded Prostate Cancer Index Composite to EuroQoL-5D-3L Using Cross-Sectional and Longitudinal Data: Secondary Analysis of NRG/RTOG 0415

Author

Khairnar, Rahul, DeMora, Lyudmila, Sandler, Howard M., Lee, W. Robert, Villalonga-Olives, Ester, Mullins, C. Daniel, Palumbo, Francis B., Bruner, Deborah W., Shaya, Fadia T., Bentzen, Soren M., Shah, Amit B., Malone, Shawn, Michalski, Jeff M., Dayes, Ian S., Seaward, Samantha A., Albert, Michele, Currey, Adam D., Pisansky, Thomas M., Chen, Yuhchyau, Horwitz, Eric M., DeNittis, Albert S., Feng, Felix, and Mishra, Mark V.

Published
2022
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29. A User's Guide and Summary of Pediatric Normal Tissue Effects in the Clinic (PENTEC): Radiation Dose-Volume Response for Adverse Effects After Childhood Cancer Therapy and Future Directions

Author

Constine, Louis S., primary, Marks, Lawrence B., additional, Milano, Michael T., additional, Ronckers, Cécile M., additional, Jackson, Andrew, additional, Hudson, Melissa M., additional, Marcus, Karen J., additional, Hodgson, David C., additional, Hua, Chia-Ho, additional, Howell, Rebecca M., additional, Marples, Brian, additional, Yorke, Ellen, additional, Olch, Arthur, additional, and Bentzen, Soren M., additional

Published
2023
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41. Study design and rationale for ELPIS: A phase I/IIb randomized pilot study of allogeneic human mesenchymal stem cell injection in patients with hypoplastic left heart syndrome

Author

Kaushal, Sunjay, Wehman, Brody, Pietris, Nicholas, Naughton, Casey, Bentzen, Soren M., Bigham, Grace, Mishra, Rachana, Sharma, Sudhish, Vricella, Luca, Everett, Allen D., Deatrick, Kristopher B., Huang, Sihong, Mehta, Helina, Ravekes, William A., Hibino, Naru, Difede, Darcy L., Khan, Aisha, and Hare, Joshua M.

Published
2017
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43. Oncological outcomes from trimodality therapy receiving definitive doses of neoadjuvant chemoradiation (≥60 Gy) and factors influencing consideration for surgery in stage III non-small cell lung cancer

Author

Vyfhuis, Melissa A.L., Bhooshan, Neha, Burrows, Whitney M., Turner, Michelle, Suntharalingam, Mohan, Donahue, James, Nichols, Elizabeth M., Feliciano, Josephine, Bentzen, Søren M., Badiyan, Shahed, Carr, Shamus R., Friedberg, Joseph, Simone, Charles B., II, Edelman, Martin J., Feigenberg, Steven J., and Mohindra, Pranshu

Published
2017
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49. Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

Author

Andreassen, Christian Nicolaj, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, De Ruysscher, Dirk, Cesaretti, Jamie A., Barnett, Gillian C., Dunning, Alison M., Dorling, Leila, West, Catharine M.L., Burnet, Neil G., Elliott, Rebecca, Coles, Charlotte, Hall, Emma, Fachal, Laura, Vega, Ana, Gómez-Caamaño, Antonio, Talbot, Christopher J., Symonds, R. Paul, De Ruyck, Kim, Thierens, Hubert, Ost, Piet, Chang-Claude, Jenny, Seibold, Petra, Popanda, Odilia, Overgaard, Marie, Dearnaley, David, Sydes, Matthew R., Azria, David, Koch, Christine Anne, Parliament, Matthew, Blackshaw, Michael, Sia, Michael, Fuentes-Raspall, Maria J., Ramon y Cajal, Teresa, Barnadas, Agustin, Vesprini, Danny, Gutiérrez-Enríquez, Sara, Mollà, Meritxell, Díez, Orland, Yarnold, John R., Overgaard, Jens, Bentzen, Søren M., and Alsner, Jan

Published
2016
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