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17 results on '"Bentsen, Christopher"'

1. Continued Transmission of HIV Among Young Adults Who Inject Drugs in San Francisco: Still Room for Improvement

Author

Mirzazadeh, Ali, Evans, Jennifer L, Hahn, Judith A, Jain, Jennifer, Briceno, Alya, Shiboski, Stephen, Lum, Paula J, Bentsen, Christopher, Davis, Geoff, Shriver, Kathy, Dimapasoc, Melanie, Stone, Mars, Busch, Michael P, and Page, Kimberly

Subjects
Public Health, Health Sciences, Sexually Transmitted Infections, Behavioral and Social Science, HIV/AIDS, Prevention, Sexual and Gender Minorities (SGM/LGBT*), Substance Misuse, Infectious Diseases, Infection, Good Health and Well Being, Adolescent, Black or African American, Cohort Studies, Drug Users, HIV Infections, Heterosexuality, Hispanic or Latino, Homosexuality, Male, Humans, Incidence, Male, San Francisco, Sexual Behavior, Substance Abuse, Intravenous, White People, Young Adult, HIV, Epidemiology, Drug users, Injection, Young adults, Cohort studies, Public Health and Health Services, Social Work, Public health
Abstract

We measured HIV incidence rate, trend and risk factors in 564 HIV-negative young people (

Published
2018

2. Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient

Author

Yukl, Steven A, Boritz, Eli, Busch, Michael, Bentsen, Christopher, Chun, Tae-Wook, Douek, Daniel, Eisele, Evelyn, Haase, Ashley, Ho, Ya-Chi, Hütter, Gero, Justement, J Shawn, Keating, Sheila, Lee, Tzong-Hae, Li, Peilin, Murray, Danielle, Palmer, Sarah, Pilcher, Christopher, Pillai, Satish, Price, Richard W, Rothenberger, Meghan, Schacker, Timothy, Siliciano, Janet, Siliciano, Robert, Sinclair, Elizabeth, Strain, Matt, Wong, Joseph, Richman, Douglas, and Deeks, Steven G

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Biotechnology, Clinical Research, Transplantation, HIV/AIDS, Sexually Transmitted Infections, Infectious Diseases, Genetics, 4.1 Discovery and preclinical testing of markers and technologies, Infection, Adult, Allografts, Anti-Retroviral Agents, Antibodies, Viral, DNA, Viral, HIV, HIV Infections, Hematopoietic Stem Cell Transplantation, Humans, RNA, Viral, Microbiology, Virology, Medical microbiology
Abstract

There is intense interest in developing curative interventions for HIV. How such a cure will be quantified and defined is not known. We applied a series of measurements of HIV persistence to the study of an HIV-infected adult who has exhibited evidence of cure after allogeneic hematopoietic stem cell transplant from a homozygous CCR5Δ32 donor. Samples from blood, spinal fluid, lymph node, and gut were analyzed in multiple laboratories using different approaches. No HIV DNA or RNA was detected in peripheral blood mononuclear cells (PBMC), spinal fluid, lymph node, or terminal ileum, and no replication-competent virus could be cultured from PBMCs. However, HIV RNA was detected in plasma (2 laboratories) and HIV DNA was detected in the rectum (1 laboratory) at levels considerably lower than those expected in ART-suppressed patients. It was not possible to obtain sequence data from plasma or gut, while an X4 sequence from PBMC did not match the pre-transplant sequence. HIV antibody levels were readily detectable but declined over time; T cell responses were largely absent. The occasional, low-level PCR signals raise the possibility that some HIV nucleic acid might persist, although they could also be false positives. Since HIV levels in well-treated individuals are near the limits of detection of current assays, more sensitive assays need to be developed and validated. The absence of recrudescent HIV replication and waning HIV-specific immune responses five years after withdrawal of treatment provide proof of a clinical cure.

Published
2013

3. HIV vaccine-induced sero-reactivity: A challenge for trial participants, researchers, and physicians

Author

Voronin, Yegor, Zinszner, Helene, Karg, Carissa, Brooks, Katie, Coombs, Robert, Hural, John, Holt, Renee, Fast, Pat, Allen, Mary, Busch, Michael, Fruth, Ulrich, Golding, Hana, Khurana, Surender, Mulenga, Joseph, Peel, Sheila, Schito, Marco, Barnabas, Nomampondo, Bentsen, Christopher, Graham, Barney, Gray, Glenda, Levin, Andrew, McCluskey, Margaret, O’Connell, Robert, Snow, Bill, and Ware, Mark

Published
2015
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9. Seroreversion in subjects receiving antiretroviral therapy during acute/early HIV infection

Author

Hare, C. Bradley, Pappalardo, Brandee L., Busch, Michael P., Karlsson, Annika C., Phelps, Bruce H., Alexander, Steven S., Bentsen, Christopher, Ramstead, Clarissa A., Nixon, Douglas F., Levy, Jay A., and Hecht, Frederick M.

Subjects
Antiviral agents -- Usage, HIV infection -- Care and treatment, Health, Health care industry, University of California -- Services
Published
2006

13. Continued Transmission of HIV Among Young Adults Who Inject Drugs in San Francisco: Still Room for Improvement

Author

Mirzazadeh, Ali, primary, Evans, Jennifer L., additional, Hahn, Judith A., additional, Jain, Jennifer, additional, Briceno, Alya, additional, Shiboski, Stephen, additional, Lum, Paula J., additional, Bentsen, Christopher, additional, Davis, Geoff, additional, Shriver, Kathy, additional, Dimapasoc, Melanie, additional, Stone, Mars, additional, Busch, Michael P., additional, and Page, Kimberly, additional

Published
2017
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16. Aspergillus Galactomannan Antigen in the Bronchoalveolar Lavage Fluid for the Diagnosis of Invasive Aspergillosis in Lung Transplant Recipients

Author

Husain, Shahid, primary, Paterson, David L., additional, Studer, Sean M., additional, Crespo, Maria, additional, Pilewski, Joseph, additional, Durkin, Michelle, additional, Wheat, Joseph L., additional, Johnson, Bruce, additional, McLaughlin, Lisa, additional, Bentsen, Christopher, additional, McCurry, Kenneth R., additional, and Singh, Nina, additional

Published
2007
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17. Prospective AspergillusGalactomannan Antigen Testing in Pediatric Hematopoietic Stem Cell Transplant Recipients

Author

Steinbach, William J., Addison, Rachel M., McLaughlin, Lisa, Gerrald, Quincy, Martin, Paul L., Driscoll, Timothy, Bentsen, Christopher, Perfect, John R., and Alexander, Barbara D.

Abstract

The galactomannan (GM) assay is an approved noninvasive test for detection of invasive aspergillosis (IA) that has been validated in adult patients with hematologic malignancies who are undergoing bone marrow transplantation. There have been few studies with this assay in pediatric patients, but early reports suggest that there may be differences in the performance such that false-positive GM tests in pediatric patients are more common than in adult patients.

Published
2007
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