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32 results on '"Benton, Ryan G."'

1. Artificial targeting of the NEIL1 DNA glycosylase to the mitochondria.

Author

Thompson, Marlo K., Eggers, Mark H., Benton, Ryan G., Johnsten, Tom, and Prakash, Aishwarya

Subjects
EXCISION repair, HUMAN DNA, CONFOCAL microscopy, GLYCOSYLASES, CELL death
Abstract

The human NEIL1 DNA glycosylase is one of 11 mammalian glycosylases that initiate base excision repair. While substrate preference, catalytic mechanism, and structural information of NEIL1's ordered residues are available, limited information on its subcellular localization, compounded by relatively low endogenous expression levels, have impeded our understanding of NEIL1. Here, we employed a previously developed computational framework to optimize the mitochondrial localization signal of NEIL1, enabling the visualization of its specific targeting to the mitochondrion via confocal microscopy. While we observed clear mitochondrial localization and increased glycosylase/lyase activity in mitochondrial extracts from low‐moderate NEIL1 expression, high NEIL1 mitochondrial expression levels proved harmful, potentially leading to cell death. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Representations for Large-Scale Sequence Data Mining: A Tale of Two Vector Space Models

Author

Raghavan, Vijay V., Benton, Ryan G., Johnsten, Tom, Xie, Ying, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Ciucci, Davide, editor, Inuiguchi, Masahiro, editor, Yao, Yiyu, editor, Ślęzak, Dominik, editor, and Wang, Guoyin, editor

Published
2013
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5. Diagnosis and Grading of Alzheimer’s Disease via Automatic Classification of FDG-PET Scans

Author

Benton, Ryan G., Choubey, Suresh, Clark, David G., Johnsten, Tom, Raghavan, Vijay V., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Imamura, Kazayuki, editor, Usui, Shiro, editor, Shirao, Tomoaki, editor, Kasamatsu, Takuji, editor, Schwabe, Lars, editor, and Zhong, Ning, editor

Published
2013
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6. Composite Kernels for Automatic Relevance Determination in Computerized Diagnosis of Alzheimer’s Disease

Author

Ayhan, Murat Seckin, Benton, Ryan G., Raghavan, Vijay V., Choubey, Suresh, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Imamura, Kazayuki, editor, Usui, Shiro, editor, Shirao, Tomoaki, editor, Kasamatsu, Takuji, editor, Schwabe, Lars, editor, and Zhong, Ning, editor

Published
2013
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7. Camera Pose Estimation by an Artificial Neural Network

Author

Benton, Ryan G., Chu, Chee-hung Henry, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, King, Irwin, editor, Wang, Jun, editor, Chan, Lai-Wan, editor, and Wang, DeLiang, editor

Published
2006
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14. Utilizing Machine Learning Techniques to Predict the Efficacy of Aerobic Exercise Intervention on Young Hypertensive Patients Based on Cardiopulmonary Exercise Testing

Author

Huang, Fangwan, primary, Leng, Xiuyu, additional, Kasukurthi, Mohan Vamsi, additional, Huang, Yulong, additional, Li, Dongqi, additional, Tan, Shaobo, additional, Lu, Guiying, additional, Lu, Juhong, additional, Benton, Ryan G., additional, Borchert, Glen M., additional, and Huang, Jingshan, additional

Published
2021
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32. Camera Pose Estimation by an Artificial Neural Network.

Author

King, Irwin, Jun Wang, Laiwan Chan, DeLiang Wang, Benton, Ryan G., and Chee-hung Henry Chu

Abstract

Reconstruction of a three-dimensional scene using images taken from two views is possible if the relative pose of the cameras is known. A traditional approach to estimating the pose of the cameras uses eight pairs of corresponding points and involves the solution of a set of homogeneous equations. We propose a multi-layered feedforward network solution. Empirical results demonstrate the feasibility of using the network to recover the relative pose of the cameras in the three-dimensional world. [ABSTRACT FROM AUTHOR]

Published
2006
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