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219 results on '"Bentley, Graham A."'

13. Functional and immunological characterization of a duffy binding-like-[gamma] domain from Plasmodium falciparum erythrocyte membrane protein-1 expressed by a placental isolate

Author

Chia, Yu-Shan, Badaut, Cyril, Tuikue Ndam, Nicaise G., Khattab, Ayman, Igonet, Sebastien, Fievet, Nadine, Bentley, Graham A., Deloron, Philippe, and Klinkert, Mo-Quen

Subjects
Pregnant women -- Health aspects, Protein binding -- Research, Plasmodium falciparum -- Diagnosis, Plasmodium falciparum -- Care and treatment, Plasmodium falciparum -- Research, Health
Published
2005

14. Crystal structure of the beta chain of a T cell antigen receptor

Author

Bentley, Graham A., Boulot, Ginette, Karjalainen, Klaus, and Mariuzza, Roy A.

Subjects
T cells -- Receptors, Antigen receptors, T cell -- Composition -- Research, Cellular signal transduction -- Research, Science and technology, Composition, Research
Abstract

The crystal structure of the extracellular portion of the β chain of a murine T cell antigen receptor (TCR), determined at a resolution of 1.7 angstroms, shows structural homology to immunoglobulins. The structure of the first and second hypervariable loops suggested that, in general, they adopt more restricted sets of conformations in TCR β chains than those found in immunoglobulins; the third hypervariable loop had certain structural characteristics in common with those of immunoglobulin heavy chain variable domains. The variable and constant domains were in close contact, presumably restricting the flexibility of the β chain. This may facilitate signal transduction from the TCR to the associated CD3 molecules in the TCR-CD3 complex., Antigen recognition by T lymphocytes is mediated by highly diverse cell-surface glycoproteins known as T cell receptors. These disulfide-linked heterodimers are composed of α and β (or γ and δ) [...]

Published
1995

18. The humoral response to Plasmodium falciparum VarO rosetting variant and its association with protection against malaria in Beninese children

Author

Bentley Graham, Juillerat Alexandre, Guillotte Micheline, Lokossou Adjimon, Vigan-Womas Inès, Garcia André, Mercereau-Puijalon Odile, and Migot-Nabias Florence

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The capacity of Plasmodium falciparum-infected erythrocytes to bind uninfected erythrocytes (rosetting) is associated with severe malaria in African children. Rosetting is mediated by a subset of the variant surface antigens PfEMP1 targeted by protective antibody responses. Analysis of the response to rosette-forming parasites and their PfEMP1 adhesive domains is essential for understanding the acquisition of protection against severe malaria. To this end, the antibody response to a rosetting variant was analysed in children recruited with severe or uncomplicated malaria or asymptomatic P. falciparum infection. Methods Serum was collected from Beninese children with severe malaria, uncomplicated malaria or P. falciparum asymptomatic infection (N = 65, 37 and 52, respectively) and from immune adults (N = 30) living in the area. Infected erythrocyte surface-reactive IgG, rosette disrupting antibodies and IgG to the parasite crude extract were analysed using the single variant Palo Alto VarO-infected line. IgG, IgG1 and IgG3 to PfEMP1-varO-derived NTS-DBL1α1, CIDRγ and DBL2βC2 recombinant domains were analysed by ELISA. Antibody responses were compared in the clinical groups. Stability of the response was studied using a blood sampling collected 14 months later from asymptomatic children. Results Seroprevalence of erythrocyte surface-reactive IgG was high in adults (100%) and asymptomatic children (92.3%) but low in children with severe or uncomplicated malaria (26.1% and 37.8%, respectively). The IgG, IgG1 and IgG3 antibody responses to the varO-derived PfEMP1 domains were significantly higher in asymptomatic children than in children with clinical malaria in a multivariate analysis correcting for age and parasite density at enrolment. They were essentially stable, although levels tended to decrease with time. VarO-surface reactivity correlated positively with IgG reactivity to the rosetting domain varO-NTS-DBL1α1. None of the children sera, including those with surface-reactive antibodies possessed anti-VarO-rosetting activity, and few adults had rosette-disrupting antibodies. Conclusions Children with severe and uncomplicated malaria had similar responses. The higher prevalence and level of VarO-reactive antibodies in asymptomatic children compared to children with malaria is consistent with a protective role for anti-VarO antibodies against clinical falciparum malaria. The mechanism of such protection seems independent of rosette-disruption, suggesting that the cytophilic properties of antibodies come into play.

Published
2010
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20. Cross-reactivity between apical membrane antgen 1 and rhoptry neck protein 2 in P. vivax and P. falciparum: A structural and binding study

Author

Vulliez-Le Normand, Brigitte, Saul, Frederick A., Hoos, Sylviane, Faber, Bart W., and Bentley, Graham A.

Subjects
Plasmodium, Immunology, Plasmodium falciparum, Protozoan Proteins, lcsh:Medicine, Cross Reactions, Arginine, Ligands, Biochemistry, Animal Cells, Red Blood Cells, Parasite Groups, parasitic diseases, Medicine and Health Sciences, Solid State Physics, Animals, Amino Acids, lcsh:Science, Cross Reactivity, Protozoans, Crystallography, Blood Cells, Merozoites, Organic Compounds, Physics, Erythrocyte Membrane, Organic Chemistry, lcsh:R, Organisms, Malarial Parasites, Chemical Compounds, Biology and Life Sciences, Proteins, Cell Biology, Condensed Matter Physics, Parasitic Protozoans, Chemistry, Physical Sciences, Crystal Structure, Parasitology, lcsh:Q, Cellular Types, Basic Amino Acids, Plasmodium vivax, Apicomplexa, Research Article, Protein Binding
Abstract

Malaria, a disease endemic in many tropical and subtropical regions, is caused by infection of the erythrocyte by the apicomplexan parasite Plasmodium. Host-cell invasion is a complex process but two Plasmodium proteins, Apical Membrane Antigen 1 (AMA1) and the Rhoptry Neck protein complex (RON), play a key role. AMA1, present on the surface of the parasite, binds tightly to the RON2 component of the RON protein complex, which is inserted into the erythrocyte membrane during invasion. Blocking the AMA1-RON2 interaction with antibodies or peptides inhibits invasion, underlining its importance in the Plasmodium life cycle and as a target for therapeutic strategies. We describe the crystal structure of the complex formed between AMA1 from P. vivax (PvAMA1) and a peptide derived from the externally exposed region of P. vivax RON2 (PvRON2sp1), and of the heterocomplex formed between P. falciparum AMA1 (PfAMA1) and PvRON2sp1. Binding studies show that the affinity of PvRON2sp1 for PvAMA1 is weaker than that previously reported for the PfRON2sp1-PfAMA1 association. Moreover, while PvRON2sp1 shows strong cross-reactivity with PfAMA1, PfRON2sp1 displays no detectable interaction with PvAMA1. The structures show that the equivalent residues PvRON2-Thr2055 and PfRON2-Arg2041 largely account for this pattern of reactivity.

Published
2017

26. Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes

Author

Guillotte, Micheline, primary, Juillerat, Alexandre, additional, Igonet, Sébastien, additional, Hessel, Audrey, additional, Petres, Stéphane, additional, Crublet, Elodie, additional, Le Scanf, Cécile, additional, Lewit-Bentley, Anita, additional, Bentley, Graham A., additional, Vigan-Womas, Inès, additional, and Mercereau-Puijalon, Odile, additional

Published
2015
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29. Identification of BDNF Sensitive Electrophysiological Markers of Synaptic Activity and Their Structural Correlates in Healthy Subjects Using a Genetic Approach Utilizing the Functional BDNF Val66Met Polymorphism

Author

Soltész, Fruzsina, primary, Suckling, John, additional, Lawrence, Phil, additional, Tait, Roger, additional, Ooi, Cinly, additional, Bentley, Graham, additional, Dodds, Chris M., additional, Miller, Sam R., additional, Wille, David R., additional, Byrne, Misha, additional, McHugh, Simon M., additional, Bellgrove, Mark A., additional, Croft, Rodney J., additional, Lu, Bai, additional, Bullmore, Edward T., additional, and Nathan, Pradeep J., additional

Published
2014
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31. Effects of the BDNF Val66Met Polymorphism and Met Allele Load on Declarative Memory Related Neural Networks

Author

Dodds, Chris M., primary, Henson, Richard N., additional, Suckling, John, additional, Miskowiak, Kamilla W., additional, Ooi, Cinly, additional, Tait, Roger, additional, Soltesz, Fruzsina, additional, Lawrence, Phil, additional, Bentley, Graham, additional, Maltby, Kay, additional, Skeggs, Andrew, additional, Miller, Sam R., additional, McHugh, Simon, additional, Bullmore, Edward T., additional, and Nathan, Pradeep J., additional

Published
2013
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32. Identification of BDNF Sensitive Electrophysiological Markers of Synaptic Activity and Their Structural Correlates in Healthy Subjects Using a Genetic Approach Utilizing the Functional BDNF Val66Met Polymorphism

Author

Fox, Michael A., Soltész, Fruzsina, Suckling, John, Lawrence, Phil, Tait, Roger, Ooi, Cinly, Bentley, Graham, Dodds, Chris M., Miller, Sam R., Wille, David R., Byrne, Misha, McHugh, Simon M., Bellgrove, Mark A., Croft, Rodney J., Lu, Bai, Bullmore, Edward T., and Nathan, Pradeep J.

Subjects
Male, Physiology, Mismatch negativity, Neuropsychological Tests, Electroencephalography, Pathology and Laboratory Medicine, Nervous System, Biochemistry, Mechanical Treatment of Specimens, Diagnostic Radiology, Methionine, Drug Discovery, Medicine and Health Sciences, Prefrontal cortex, Multidisciplinary, medicine.diagnostic_test, Cognitive Neurology, Radiology and Imaging, Brain, Neurodegenerative Diseases, Valine, Middle Aged, Magnetic Resonance Imaging, Healthy Volunteers, Electrophysiology, Electroporation, medicine.anatomical_structure, Neurology, Specimen Disruption, Medicine, Female, Anatomy, Alzheimer's disease, Research Article, Adult, medicine.medical_specialty, Drug Research and Development, Genotype, Science, Cognitive Neuroscience, Grey matter, Research and Analysis Methods, Young Adult, Diagnostic Medicine, Event-related potential, Genetics, medicine, Humans, Psychiatry, Pharmacology, Brain-derived neurotrophic factor, Evolutionary Biology, Polymorphism, Genetic, business.industry, Brain-Derived Neurotrophic Factor, Biology and Life Sciences, Human Genetics, medicine.disease, Specimen Preparation and Treatment, Synapses, Genetic Polymorphism, Clinical Medicine, business, Functional magnetic resonance imaging, Neuroscience, Biomarkers, Population Genetics
Abstract

Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. Brain-derived neurotropic factor (BDNF) is key synaptogenic molecule and targeting synaptic repair through modulation of BDNF signalling has been suggested as a potential drug discovery strategy. The development of such "synaptogenic" therapies depend on the availability of BDNF sensitive markers of synaptic function that could be utilized as biomarkers for examining target engagement or drug efficacy in humans. Here we have utilized the BDNF Val66Met genetic polymorphism to examine the effect of the polymorphism and genetic load (i.e. Met allele load) on electrophysiological (EEG) markers of synaptic activity and their structural (MRI) correlates. Sixty healthy adults were prospectively recruited into the three genetic groups (Val/Val, Val/Met, Met/Met). Subjects also underwent fMRI, tDCS/TMS, and cognitive assessments as part of a larger study. Overall, some of the EEG markers of synaptic activity and brain structure measured with MRI were the most sensitive markers of the polymorphism. Met carriers showed decreased oscillatory activity and synchrony in the neural network subserving error-processing, as measured during a flanker task (ERN); and showed increased slow-wave activity during resting. There was no evidence for a Met load effect on the EEG measures and the polymorphism had no effects on MMN and P300. Met carriers also showed reduced grey matter volume in the anterior cingulate and in the (left) prefrontal cortex. Furthermore, anterior cingulate grey matter volume, and oscillatory EEG power during the flanker task predicted subsequent behavioural adaptation, indicating a BDNF dependent link between brain structure, function and behaviour associated with error processing and monitoring. These findings suggest that EEG markers such as ERN and resting EEG could be used as BDNF sensitive functional markers in early clinical development to examine target engagement or drug related efficacy of synaptic repair therapies in humans.

Published
2014

34. Graham Bentley: Why DFM models are rarely worth paying for

Author

Bentley, Graham

Subjects
Portfolio management, Banking, finance and accounting industries, Business
Abstract

Byline: Graham Bentley There are numerous activities that one human will offer another in exchange for money. Not all those activities are economically rational -- homeopathy, for example. Some people [...]

Published
2014

36. Graham Bentley: Chickens or pigs? Clients' involvement in the advice process

Author

Bentley, Graham

Subjects
Financial planners, Banking, finance and accounting industries, Business
Abstract

Byline: Graham Bentley Martina Navratilova once described ainvolvementa versus acommitmenta as being like ham and eggs a the chicken is involved, but the pig is committed. The degree to which [...]

Published
2014

37. Graham Bentley: Wealth is no sign of authority

Author

Bentley, Graham

Subjects
Banking, finance and accounting industries, Business
Abstract

Byline: Graham Bentley Knowledge is instantly available today -- pub quiz scores have probably risen dramatically since the introduction of the smart phone. But knowledge isn't learning if it isn't [...]

Published
2014

38. Graham Bentley: Do not underestimate the impact of charges

Author

Bentley, Graham

Subjects
Costs (Law), Banking, finance and accounting industries, Business
Abstract

Byline: Graham Bentley 'Suitability' is set to become Financial Services' CyGreat Matter'. Practitioners' text-book opinions on client needs may not match their real-life (and often irrational) Cywants'. Regarding investment advice, [...]

Published
2014

39. The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction

Author

Nathan, Pradeep J., primary, Watson, Jeannette, additional, Lund, Jesper, additional, Davies, Ceri H., additional, Peters, Gary, additional, Dodds, Chris M., additional, Swirski, Bridget, additional, Lawrence, Philip, additional, Bentley, Graham D., additional, O'Neill, Barry V., additional, Robertson, Jon, additional, Watson, Stephen, additional, Jones, Gareth A., additional, Maruff, Paul, additional, Croft, Rodney J., additional, Laruelle, Marc, additional, and Bullmore, Edward T., additional

Published
2013
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41. Structural Basis for the ABO Blood-Group Dependence of Plasmodium falciparum Rosetting

Author

Vigan-Womas, Inès, primary, Guillotte, Micheline, additional, Juillerat, Alexandre, additional, Hessel, Audrey, additional, Raynal, Bertrand, additional, England, Patrick, additional, Cohen, Jacques H., additional, Bertrand, Olivier, additional, Peyrard, Thierry, additional, Bentley, Graham A., additional, Lewit-Bentley, Anita, additional, and Mercereau-Puijalon, Odile, additional

Published
2012
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45. The RON2-AMA1 Interaction is a Critical Step in Moving Junction-Dependent Invasion by Apicomplexan Parasites

Author

Lamarque, Mauld, primary, Besteiro, Sébastien, additional, Papoin, Julien, additional, Roques, Magali, additional, Vulliez-Le Normand, Brigitte, additional, Morlon-Guyot, Juliette, additional, Dubremetz, Jean-François, additional, Fauquenoy, Sylvain, additional, Tomavo, Stanislas, additional, Faber, Bart W., additional, Kocken, Clemens H., additional, Thomas, Alan W., additional, Boulanger, Martin J., additional, Bentley, Graham A., additional, and Lebrun, Maryse, additional

Published
2011
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49. Biochemical and biophysical characterisation of DBL1α1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum

Author

Juillerat, Alexandre, primary, Igonet, Sébastien, additional, Vigan-Womas, Inès, additional, Guillotte, Micheline, additional, Gangnard, Stéphane, additional, Faure, Grazyna, additional, Baron, Bruno, additional, Raynal, Bertrand, additional, Mercereau-Puijalon, Odile, additional, and Bentley, Graham A., additional

Published
2010
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50. Structural Mimicry of O-Antigen by a Peptide Revealed in a Complex with an Antibody Raised against Shigella flexneri Serotype 2a

Author

Theillet, François-Xavier, primary, Saul, Frederick A., additional, Vulliez-Le Normand, Brigitte, additional, Hoos, Sylviane, additional, Felici, Franco, additional, Weintraub, Andrej, additional, Mulard, Laurence A., additional, Phalipon, Armelle, additional, Delepierre, Muriel, additional, and Bentley, Graham A., additional

Published
2009
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