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4. Factors associated with failed epidural blood patch after accidental dural puncture in obstetrics: a prospective, multicentre, international cohort study

Author

Casier, Isabelle, Bryon, Bart, Soetens, Filiep, Dewandre, Pierre-Yves, Lambert, Geraldine, Christiaen, Jan, Schepers, Roel, Van Houwe, Patrick, Kalmar, Alain, Vanoverschelde, Henk, Bauters, Monique, Roofthooft, Eva, Devroe, Sarah, Van de Velde, Marc, Jadrijevic, Ana, Jokic, Aleksandra, Marin, Damjan, Sklebar, Ivan, Mihaljević, Slobodan, Kosinova, Martina, Stourac, Petr, Adamus, Milan, Kufa, Christian, Volfová, Ivana, Zaoralová, Blažena, Froeslev-Friis, Christina, Mygil, Bjoern, Krebs Albrechtsen, Charlotte, Kavasmaa, Tomi, Alahuhta, Seppo, Mäyrä, Anne, Mennander, Susanna, Rautaneva, Kati, Hiekkanen, Tuula, Kontinen, Vesa, Linden, Kirsti, Toivakka, Sara, Boselli, Emmanuel, Greil, Pierre-Édouard, Mascle, Olivier, Courbon, Aurelie, Lutz, Jean., Simonet, Thérèse, Barbier, Marie, Hlioua, Tarik, Meniolle d’Hauthville, Fleur, Quintin, Christine, Bouattour, Karim, Lecinq, Agnès, Mercier, Frederic, Bonnet, Marie-Pierre, Carbonniere, Mathieu, Fischer, Catherine, Picard, Paola-Carla, Bonnin, Martine, Storme, Brigitte, Bouthors, Anne-Sophie, Detente, Thomas, Nguyen, Truong Minh, Keita, Hawa, Nebout, Sophie, Osse, Lauranne, Delmas, Anne, Vial, Florence, Kaufner, Lutz, Hoefing, Christoph, Mueller, Stefan, Becke, Karin, Blobner, Manfred, Lewald, Heidrun, Schaller, Stefan Josef, Muggleton, Ellis, Bette, Birgit, Neumann, Claudia, Weber, Stefan, Grünewald, Matthias, Ohnesorge, Henning, Helf, Antonia, Jelting, Yvonne, Kranke, Peter, von Heymann, Christian, Welfle, Sabine, Staikou, Chryssoula, Stavrianopoulou, Antonia, Stamelos, Mattheios, Kalopita, Konstantina, Loukeri, Anastasia, Valsamidis, Dimitrios, Matsota, Paraskevi, Thorsteinsson, Adalbjörn, Tome, Riad, Eidelman, Leonid A., Davis, Atara, Orbach-Zinger, Sharon, Ioscovich, Alexander, Ramona, Iacob, De Simone, Luigi, Pesetti, Barbara, Brazzi, Luca, Zito, Alessandro, Camorcia, Michela, Della Rocca, Giorgio, Aversano, Marco, Frigo, Maria Grazia, Todde, Cristina, Macas, Andrius, Keraitiene, Grazina, Rimaitis, Kestutis, Borg, Francis, Tua, Carl, Kuijpers-Visser, Agnes Geertje, Schyns-van den Berg, Alexandra, Hollmann, Markus W., van den Berg, Tijs, Koolen, Eric, Dons, Ilse, van der Knijff, Anouk, van der Marel, Caroline, Ruysschaert, Nele, Pelka, Michal, Pluymakers, Christine, Koopman, Seppe, Teunissen, Aart-Jan, Cornelisse, Dick, van Dasselaar, Nick, Verdouw, Bastiaan, Beenakkers, Ingrid, Dahl, Vegard, Hagen, Robert, Vivaldi, Francesco, Eriksen, John Reidar, Wiszt, Radovan, Aslam Tayyba, Naz, Ringvold, Else-Marie, Chutkowski, Radosław, Skirecki, Tomasz, Wódarski, Bartłomiej, Faria, Maria Aida, Ferreira, Amélia, Sampaio, Ana Catarina, Ferreira, Irene, Matias, Bernardo, Teixeira, Joana, Araujo, Rita, Cabido, Herminia, Fortuna, Rosario, Lemos, Paulo, Cardoso, Carolina, Moura, Fernando, Pereira, Cristiana, Pereira, Sandra, Abecasis, Manuel, Lança, Filipa, Muchacho, Paulo, Ormonde, Lucindo, Guedes-Araujo, Isabel, Pinho-Oliveira, Vitor, Paredes, Paulo, Bentes, Carla, Gouveia, Francisco, Milheiro, Ana, Castanheira, Cláudia, Neves, Miriam, Pacheco, Vânia, Cortez, Mara, Tranquada, Raquel, Tareco, Glória, Furtado, Inês, Pereira, Estela, Marinho, Luísa, Seabra, Manuel, Bulasevic, Aleksandra, Kendrisic, Mirjana, Jovanovic, Lidija, Pujić, Borislava, Kutlesic, Marija, Grochova, Monika, Simonova, Jana, Pavlovic, Gordana, Rozman, Ales, Blajic, Iva, Graovac, Dragan, Stopar Pintaric, Tatjana, Chiquito, Teresa, Monedero, Pablo, De Carlos-Errea, Joaquin, Guillén-Casbas, Roque, Veiga-Gil, Leonor, Basso, Morena, Garcia Bartolo, Carolina, Hernandez, Cristian, Ricol, Laura, De Santos, Maroto Pinar, Gràcia Solsona, Josep A., López-Baamonde, Manuel, Magaldi Mendaña, Marta, Plaza Moral, Ana María, Vendrell, Marina, Trillo, Lourdes, Perez Garcia, Anibal Ricardo, Alamillo Salas, Clara, Moret, Enric, Ramió, Laura, Aguilar Sanchez, Jose Luis, Soler Pedrola, Maria, Valldeperas Hernandez, Maria Inmaculada, Aldalur, Gorka, Bárcena, Estíbaliz, Herrera, Julia, Iturri, Fernando, Martínez, Alberto, Martínez, Leire, Serna, Rosa, Gilsanz, Fernando, Guasch Arevalo, Emilia, Iannuccelli, Fabrizio, Latorre, Julieta, Rodriguez Roca, Cristina, Pérez Pardo, Osvaldo Ceferino, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Hernández González, Lourdes, Remacha González, Caridad, Sánchez Nuez, Raquel, Anta, Diego, Beleña, Jose M., García-Cuadrado, Carmen, Garcia, Irene, Manrique, Susana, Suarez, Elena, Hein, Anette, Arbman, Elisabet, Hansson, Helena, Tillenius, Monika, Al-Taie, Ruaa, Ledin-Eriksson, Susanne, Lindén-Söndersö, Anja, Rosén, Ola, Austruma, Evija, Gillberg, Lars, Darvish, Bijan, Gupta, Anil, Jörnvall, Henrik, Nordström, Johan, Persson, Jan, Rosenberg, Jan, Brühne, Lars, Forshammar, Johan, Ugarph Edfeldt, Malin, Rolfsson, Håkan, Hellblom, Anna, Levin, Katarina, Rabow, Sofus, Thorlacius, Karin, Bansch, Peter, Robertson (Baeriswyl), Moira, Stamer, Ulrike, Mathivon, Stanislas, Savoldelli, Georges, Auf der Maur, Pia, Filipovic, Miodrag, Dullenkopf, Alexander, Brunner, Maya, Girard, Thierry, Vonlanthen, Claudia, Ozbilgin, Sule, Gunaydin D, Berrin, Corman Dincer, Pelin, Tas Tuna, Ayca, Daamen, Sylvia, Farsi, Slama, Feijten, Prisca, Harlet, Pierre, Leva, Brigitte, Plichon, Benoît, Magnuson, Anders, Guasch, Emilia, Mercier, Frédéric J., and Schyns-van den Berg, Alexandra M.J.V.

Published
2022
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6. Selective modulation of epileptic tissue by an adenosine A3 receptor‐activating drug.

Author

Ghosh, Anwesha, Ribeiro‐Rodrigues, Leonor, Ruffolo, Gabriele, Alfano, Veronica, Domingos, Cátia, Rei, Nádia, Tosh, Dilip K., Rombo, Diogo M., Morais, Tatiana P., Valente, Cláudia A., Xapelli, Sara, Bordadágua, Beatriz, Rainha‐Campos, Alexandre, Bentes, Carla, Aronica, Eleonora, Diógenes, Maria José, Vaz, Sandra H., Ribeiro, Joaquim A., Palma, Eleonora, and Jacobson, Kenneth A.

Subjects
GABA transporters, SURGICAL excision, ADENOSINES, HIPPOCAMPUS (Brain), PEOPLE with epilepsy, GABA receptors
Abstract

Background and Purpose: Adenosine, through the A1 receptor (A1R), is an endogenous anticonvulsant. The development of adenosine receptor agonists as antiseizure medications has been hampered by their cardiac side effects. A moderately A1R‐selective agonist, MRS5474, has been reported to suppress seizures without considerable cardiac action. Hypothesizing that this drug could act through other than A1R and/or through a disease‐specific mechanism, we assessed the effect of MRS5474 on the hippocampus. Experimental Approach: Excitatory synaptic currents, field potentials, spontaneous activity, [3H]GABA uptake and GABAergic currents were recorded from rodent or human hippocampal tissue. Alterations in adenosine A3 receptor (A3R) density in human tissue were assessed by Western blot. Key Results: MRS5474 (50–500 nM) was devoid of effect upon rodent excitatory synaptic signals in hippocampal slices, except when hyperexcitability was previously induced in vivo or ex vivo. MRS5474 inhibited GABA transporter type 1 (GAT‐1)‐mediated γ‐aminobutyric acid (GABA) uptake, an action not blocked by an A1R antagonist but blocked by an A3R antagonist and mimicked by an A3R agonist. A3R was overexpressed in human hippocampal tissue samples from patients with epilepsy that had focal resection from surgery. MRS5474 induced a concentration‐dependent potentiation of GABA‐evoked currents in oocytes micro‐transplanted with human hippocampal membranes prepared from epileptic hippocampal tissue but not from non‐epileptic tissue, an action blocked by an A3R antagonist. Conclusion and Implications: We identified a drug that activates A3R and has selective actions on epileptic hippocampal tissue. This underscores A3R as a promising target for the development of antiseizure medications. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Implications for driving based on the risk of seizures after ischaemic stroke

Author

Schubert, Kai Michael, primary, Bicciato, Giulio, additional, Sinka, Lucia, additional, Abraira, Laura, additional, Santamarina, Estevo, additional, Álvarez-Sabín, José, additional, Ferreira-Atuesta, Carolina, additional, Katan, Mira, additional, Scherrer, Natalie, additional, Terziev, Robert, additional, Döhler, Nico, additional, Erdélyi-Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Winklehner, Michael, additional, von Oertzen, Tim J, additional, Wagner, Judith N, additional, Gigli, Gian Luigi, additional, Nilo, Annacarmen, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Zafra-Sierra, María Paula, additional, Mayor-Romero, Luis Carlos, additional, Conrad, Julian, additional, Evers, S, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Rita, additional, Pinho e Melo, Teresa, additional, Keezer, Mark R, additional, Duncan, John Sidney, additional, Sander, Josemir W, additional, Tettenborn, Barbara, additional, Koepp, Matthias, additional, and Galovic, Marian, additional

Published
2024
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10. Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry.

Author

Kaufmann, Elisabeth, Peltola, Jukka, Colon, Albert J., Lehtimäki, Kai, Majtanik, Milan, Mai, Jürgen K., Bóné, Beata, Bentes, Carla, Coenen, Volker, Gil‐Nagel, Antonio, Goncalves‐Ferreira, Antonio J., Ryvlin, Philippe, Taylor, Rod, Brionne, Thomas C., Gielen, Frans, Song, Shannon, and Boon, Paul

Subjects
DEEP brain stimulation, PARTIAL epilepsy, EPILEPSY surgery, NEURAL stimulation, EPILEPSY, BRAIN stimulation, TEMPORAL lobectomy
Abstract

Objective: Short‐term outcomes of deep brain stimulation of the anterior nucleus of the thalamus (ANT‐DBS) were reported for people with drug‐resistant focal epilepsy (PwE). Because long‐term data are still scarce, the Medtronic Registry for Epilepsy (MORE) evaluated clinical routine application of ANT‐DBS. Methods: In this multicenter registry, PwE with ANT‐DBS were followed up for safety, efficacy, and battery longevity. Follow‐up ended after 5 years or upon study closure. Clinical characteristics and stimulation settings were compared between PwE with no benefit, improvers, and responders, that is, PwE with average monthly seizure frequency reduction rates of ≥50%. Results: Of 170 eligible PwE, 104, 62, and 49 completed the 3‐, 4‐, and 5‐year follow‐up, respectively. Most discontinuations (68%) were due to planned study closure as follow‐up beyond 2 years was optional. The 5‐year follow‐up cohort had a median seizure frequency reduction from 16 per month at baseline to 7.9 per month at 5‐year follow‐up (p <.001), with most‐pronounced effects on focal‐to‐bilateral tonic–clonic seizures (n = 15, 77% reduction, p =.008). At last follow‐up (median 3.5 years), 41% (69/170) of PwE were responders. Unifocal epilepsy (p =.035) and a negative history of epilepsy surgery (p =.002) were associated with larger average monthly seizure frequency reductions. Stimulation settings did not differ between response groups. In 179 implanted PwE, DBS‐related adverse events (AEs, n = 225) and serious AEs (n = 75) included deterioration in epilepsy or seizure frequency/severity/type (33; 14 serious), memory/cognitive impairment (29; 3 serious), and depression (13; 4 serious). Five deaths occurred (none were ANT‐DBS related). Most AEs (76.3%) manifested within the first 2 years after implantation. Activa PC depletion (n = 37) occurred on average after 45 months. Significance: MORE provides further evidence for the long‐term application of ANT‐DBS in clinical routine practice. Although clinical benefits increased over time, side effects occurred mainly during the first 2 years. Identified outcome modifiers can help inform PwE selection and management. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Molecular characterization of the circadian clock in patients with Parkinson's disease–CLOCK4PD Study protocol.

Author

Yalçin, Müge, Peralta, Ana Rita, Bentes, Carla, Silva, Cristiana, Guerreiro, Tiago, Ferreira, Joaquim J., and Relógio, Angela

Subjects
CIRCADIAN rhythms, PARKINSON'S disease, RESEARCH protocols, SLEEP, SLEEP interruptions, SEX (Biology), GENE expression profiling, DEEP brain stimulation
Abstract

Introduction: Circadian rhythms (CRs) orchestrate intrinsic 24-hour oscillations which synchronize an organism's physiology and behaviour with respect to daily cycles. CR disruptions have been linked to Parkinson's Disease (PD), the second most prevalent neurodegenerative disorder globally, and are associated to several PD-symptoms such as sleep disturbances. Studying molecular changes of CR offers a potential avenue for unravelling novel insights into the PD progression, symptoms, and can be further used for optimization of treatment strategies. Yet, a comprehensive characterization of the alterations at the molecular expression level for core-clock and clock-controlled genes in PD is still missing. Methods and analysis: The proposed study protocol will be used to characterize expression profiles of circadian genes obtained from saliva samples in PD patients and controls. For this purpose, 20 healthy controls and 70 PD patients will be recruited. Data from clinical assessment, questionnaires, actigraphy tracking and polysomnography will be collected and clinical evaluations will be repeated as a follow-up in one-year time. We plan to carry out sub-group analyses considering several clinical factors (e.g., biological sex, treatment dosages, or fluctuation of symptoms), and to correlate reflected changes in CR of measured genes with distinct PD phenotypes (diffuse malignant and mild/motor-predominant). Additionally, using NanoStringⓇ multiplex technology on a subset of samples, we aim to further explore potential CR alterations in hundreds of genes involved in neuropathology pathways. Discussion: CLOCK4PD is a mono-centric, non-interventional observational study aiming at the molecular characterization of CR alterations in PD. We further plan to determine physiological modifications in sleep and activity patterns, and clinical factors correlating with the observed CR changes. Our study may provide valuable insights into the intricate interplay between CR and PD with a potential to be used as a predictor of circadian alterations reflecting distinct disease phenotypes, symptoms, and progression outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Management practices for postdural puncture headache in obstetrics: a prospective, international, cohort study

Author

Casier, Isabelle, Bryon, Bart, Soetens, Filiep, Dewandre, Pierre-Yves, Lambert, Geraldine, Christiaen, Jan, Schepers, Roel, Van Houwe, Patrick, Kalmar, Alain, Vanoverschelde, Henk, Bauters, Monique, Roofthooft, Eva, Devroe, Sarah, Van de Velde, Marc, Jadrijevic, Ana, Jokic, Aleksandra, Marin, Damjan, Sklebar, Ivan, Mihaljević, Slobodan, Kosinova, Martina, Stourac, Petr, Adamus, Milan, Kufa, Christian, Volfová, Ivana, Zaoralová, Blažena, Froeslev-Friis, Christina, Mygil, Bjoern, Krebs Albrechtsen, Charlotte, Kavasmaa, Tomi, Alahuhta, Seppo, Mäyrä, Anne, Mennander, Susanna, Rautaneva, Kati, Hiekkanen, Tuula, Kontinen, Vesa, Linden, Kirsti, Toivakka, Sara, Boselli, Emmanuel, Greil, Pierre-Édouard, Mascle, Olivier, Courbon, Aurelie, Lutz, Jean, Simonet, Thérèse, Barbier, Marie, Hlioua, Tarik, Meniolle d’Hauthville, Fleur, Quintin, Christine, Bouattour, Karim, Lecinq, Agnès, Soued, Mickaël, Bonnet, Marie-Pierre, Carbonniere, Mathieu, Fischer, Catherine, Picard, Paola-Carla, Bonnin, Martine, Storme, Brigitte, Bouthors, Anne-Sophie, Detente, Thomas, Nguyen Troung, Minh, Keita, Hawa, Nebout, Sophie, Osse, Lauranne, Delmas, Anne, Vial, Florence, Kaufner, Lutz, Hoefing, Christoph, Mueller, Stefan, Becke, Karin, Blobner, Manfred, Lewald, Heidrun, Schaller, Stefan Josef, Muggleton, Ellis, Bette, Birgit, Neumann, Claudia, Weber, Stefan, Grünewald, Matthias, Ohnesorge, Henning, Helf, Antonia, Jelting, Yvonne, Kranke, Peter, von Heymann, Christian, Welfle, Sabine, Staikou, Chryssoula, Stavrianopoulou, Antonia, Tsaroucha, Athanasia, Kalopita, Konstantina, Loukeri, Anastasia, Valsamidis, Dimitrios, Matsota, Paraskevi, Thorsteinsson, Adalbjörn, Tome, Riad, Eidelman, Leonid A., Davis, Atara, Orbach-Zinger, Sharon, Ioscovich, Alexander, Ramona, Iacob, De Simone, Luigi, Pesetti, Barbara, Brazzi, Luca, Zito, Alessandro, Camorcia, Michela, Della Rocca, Giorgio, Aversano, Marco, Frigo, Maria Grazia, Todde, Cristina, Morina, Qamile, Macas, Andrius, Keraitiene, Grazina, Rimaitis, Kestutis, Borg, Francis, Tua, Carl, Kuijpers-Visser, Agnes Geertje, Schyns-van den Berg, Alexandra, Hollmann, Markus W., Van den Berg, Tijs, Koolen, Eric, Dons, Ilse, van der Knijff, Anouk, van der Marel, Caroline, Ruysschaert, Nele, Pelka, Michal, Pluymakers, Christine, Koopman, Seppe, Teunissen, Aart-Jan, Cornelisse, Dick, van Dasselaar, Nick, Verdouw, Bastiaan, Beenakkers, Ingrid, Dahl, Vegard, Hagen, Robert, Vivaldi, Francesco, Eriksen, John Reidar, Wiszt, Radovan, Aslam Tayyaba, Naz, Ringvold, Else-Marie, Chutkowski, Radosław, Skirecki, Tomasz, Wódarski, Bartłomiej, Faria, Maria Aida, Ferreira, Amélia, Sampaio, Ana Catarina, Ferreira, Irene, Matias, Bernardo, Teixeira, Joana, Araujo, Rita, Cabido, Herminia, Fortuna, Rosario, Lemos, Paulo, Cardoso, Carolina, Moura, Fernando, Pereira, Cristiana, Pereira, Sandra, Tavares, Francisca, Vasconcelos, Pedro, Abecasis, Manuel, Lança, Filipa, Muchacho, Paulo, Ormonde, Lucindo, Guedes-Araujo, Isabel, Pinho-Oliveira, Vitor, Paredes, Paulo, Bentes, Carla, Gouveia, Francisco, Milheiro, Ana, Castanheira, Cláudia, Neves, Miriam, Pacheco, Vânia, Cortez, Mara, Tranquada, Raquel, Tareco, Glória, Furtado, Inês, Pereira, Estela, Marinho, Luísa, Seabra, Manue, Bulasevic, Aleksandra, Kendrisic, Mirjana, Jovanovic, Lidija, Pujić, Borislava, Kutlesic, Marija, Grochova, Monika, Simonova, Jana, Pavlovic, Gordana, Rozman, Ales, Blajic, Iva, Graovac, Dragan, Stopar Pintraic, Tatjana, Chiquito, Teresa, Monedero, Pablo, Carlos-Errea, De Joaquin, Guillén-Casbas, Roque, Veiga-Gil, Leonor, Basso, Morena, Garcia Bartolo, Carolina, Hernandez, Cristian, Ricol, Laura, De Santos, Maroto Pinar, Gràcia Solsona, Josep A., López-Baamonde, Manuel, Magaldi Mendaña, Marta, Plaza Moral, Ana María, Vendrell, Marina, Trillo, Lourdes, Perez Garcia, Anibal Ricardo, Alamillo Salas, Clara, Moret, Enric, Ramió, Laura, Aguilar Sanchez, Jose Luis, Soler Pedrola, Maria, Valldeperas Hernandez, Maria Inmaculada, Aldalur, Gorka, Bárcena, Estíbaliz, Herrera, Julia, Iturri, Fernando, Martínez, Alberto, Martínez, Leire, Serna, Rosa, Gilsanz, Fernando, Guasch Arevalo, Emilia, Iannuccelli, Fabrizio, Latorre, Julieta, Rodriguez Roca, Cristina, Pérez Pardo, Osvaldo Ceferino, Sierra Biddle, Natalia, Suárez Cendaña, Ceferina, Hernández González, Lourdes, Remacha González, Caridad, Sánchez Nuez, Raquel, Anta, Diego, Beleña, Jose M., García-Cuadrado, Carmen, Garcia, Irene, Manrique, Susana, Suarez, Elena, Hein, Anette, Arbman, Elisabet, Hansson, Helena, Tillenius, Monika, Al-Taie, Ruaa, Ledin-Eriksson, Susanne, Lindén-Söndersö, Anja, Rosén, Ola, Austruma, Evija, Gillberg, Lars, Darvish, Bijan, Gupta, Anil, Nordstöm, Johan L., Persson, Jan, Rosenberg, Jan, Brühne, Lars, Forshammar, Johan, Ugarph Edfeldt, Malin, Rolfsson, Håkan, Hellblom, Anna, Levin, Katarina, Rabow, Sofus, Thorlacius, Karin, Bansch, Peter, Robertson (Baeriswyl), Moira, Stamer, Ulrike, Mathivon, Stanislas, Savoldelli, Georges, Auf der Maur, Pia, Filipovic, Miodrag, Dullenkopf, Alexander, Brunner, Maya, Girard, Thierry, Vonlanthen, Claudia, Ozbilgin, Sule, Gunaydin D, Berrin, Corman Dincer, Pelin, Tas Tuna, Ayca, Magnuson, Anders, Fernando, Roshan, Mercier, Frédéric J., and Schyns-van den Berg, Alexandra M.J.V.

Published
2020
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22. Histopathological characterization of cerebral small vessel disease in epilepsy patients with temporal lobe epilepsy submitted to surgery: A case–control study

Author

Coelho, Pedro, primary, Madureira, João, additional, Franco, Ana, additional, Peralta, Ana Rita, additional, Bentes, Carla, additional, Campos, Alexandre Rainha, additional, Anink, Jasper, additional, Aronica, Eleonora, additional, Roque, Rafael, additional, and Pimentel, José, additional

Published
2023
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24. Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate

Author

Koepp, Matthias J., primary, Trinka, Eugen, additional, Mah, Yee‐Haur, additional, Bentes, Carla, additional, Knake, Susanne, additional, Gigli, Gian Luigi, additional, Serratosa, José M., additional, Zelano, Johan, additional, Magalhães, Luís M., additional, Pereira, Ana, additional, Moreira, Joana, additional, and Soares‐da‐Silva, Patrício, additional

Published
2023
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25. Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model

Author

Sinka, Lucia, primary, Abraira, Laura, additional, Imbach, Lukas L., additional, Zieglgänsberger, Dominik, additional, Santamarina, Estevo, additional, Álvarez-Sabín, José, additional, Ferreira-Atuesta, Carolina, additional, Katan, Mira, additional, Scherrer, Natalie, additional, Bicciato, Giulio, additional, Terziev, Robert, additional, Simmen, Cyril, additional, Schubert, Kai Michael, additional, Elshahabi, Adham, additional, Baumann, Christian R., additional, Döhler, Nico, additional, Erdélyi-Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Winklehner, Michael, additional, von Oertzen, Tim J., additional, Wagner, Judith N., additional, Gigli, Gian Luigi, additional, Serafini, Anna, additional, Nilo, Annacarmen, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Zafra-Sierra, María Paula, additional, Bayona-Ortiz, Hernan, additional, Conrad, Julian, additional, Evers, Stefan, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Ana Rita, additional, Pinho e Melo, Teresa, additional, Keezer, Mark R., additional, Duncan, John S., additional, Sander, Josemir W., additional, Tettenborn, Barbara, additional, Koepp, Matthias J., additional, and Galovic, Marian, additional

Published
2023
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26. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry

Author

Peltola, Jukka, Colon, Albert A., Pimentel, Jose, Coenen, Volker, Gil-Nagel, Antonio, Goncalves Ferreira, Antonio, Lehtimaki, Kai S., Ryvlin, Philippe, Taylor, Rod, Ackermans, Linda, Ardesch, Jacqueline, Bentes, Carla G., Bosak, Magdalena, Burneo, Jorge E., Chamadoira, Clara, Elger, Christian, Eross, Lorand, Fabo, Daniel, Faulkner, Howard, Gawlowicz, Jacek, Gharabaghi, Alireza, Iacoangeli, Maurizio, Janszky, Jozsef, Jarvenpaa, Soila H., Kaufmann, Elisabeth, Kho, Kuan H., Kumlien, Eva, Laufs, Helmut, Lettieri, Christian, Linhares, Paulo, Noachtar, Soheyl, Parrent, Andrew K., Pataraia, Ekaterina, Patel, Nikunj K., Peralta, Ana Rita, Racz, Attila, Campos, Alexandre Rainha A., Rego, Ricardo, Ricciuti, Riccardo, Rona, Sabine, Rouhl, Rob P. W., Schulze-Bonhage, Andreas, Schuurman, Rick, Sprengers, Mathieu, Sufianov, Albert, Temel, Yasin, Theys, Tom, Van Paesschen, Wim, Van Roost, Dirk, Vaz, Rui, Vonck, Kristl, Wagner, Louis, Zwemmer, Jack C., Abouihia, Abdallah, Brionne, Thomas, Gielen, Frans, Boon, Paul A. J. M., Peltola, Jukka, Colon, Albert A., Pimentel, Jose, Coenen, Volker, Gil-Nagel, Antonio, Goncalves Ferreira, Antonio, Lehtimaki, Kai S., Ryvlin, Philippe, Taylor, Rod, Ackermans, Linda, Ardesch, Jacqueline, Bentes, Carla G., Bosak, Magdalena, Burneo, Jorge E., Chamadoira, Clara, Elger, Christian, Eross, Lorand, Fabo, Daniel, Faulkner, Howard, Gawlowicz, Jacek, Gharabaghi, Alireza, Iacoangeli, Maurizio, Janszky, Jozsef, Jarvenpaa, Soila H., Kaufmann, Elisabeth, Kho, Kuan H., Kumlien, Eva, Laufs, Helmut, Lettieri, Christian, Linhares, Paulo, Noachtar, Soheyl, Parrent, Andrew K., Pataraia, Ekaterina, Patel, Nikunj K., Peralta, Ana Rita, Racz, Attila, Campos, Alexandre Rainha A., Rego, Ricardo, Ricciuti, Riccardo, Rona, Sabine, Rouhl, Rob P. W., Schulze-Bonhage, Andreas, Schuurman, Rick, Sprengers, Mathieu, Sufianov, Albert, Temel, Yasin, Theys, Tom, Van Paesschen, Wim, Van Roost, Dirk, Vaz, Rui, Vonck, Kristl, Wagner, Louis, Zwemmer, Jack C., Abouihia, Abdallah, Brionne, Thomas, Gielen, Frans, and Boon, Paul A. J. M.

Abstract

Background and Objectives The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice. Methods MORE is an observational registry collecting prospective and retrospective clinical data. Participants were at least 18 years old, with focal DRE recruited across 25 centers from 13 countries. They were followed for at least 2 years in terms of seizure frequency (SF), responder rate (RR), health-related quality of life (Quality of Life in Epilepsy Inventory 31), depression, and safety outcomes. Results Of the 191 patients recruited, 170 (mean [SD] age of 35.6 [10.7] years, 43% female) were implanted with DBS therapy and met all eligibility criteria. At baseline, 38% of patients reported cognitive impairment. The median monthly SF decreased by 33.1% from 15.8 at baseline to 8.8 at 2 years (p < 0.0001) with 32.3% RR. In the subgroup of 47 patients who completed 5 years of follow-up, the median monthly SF decreased by 55.1% from 16 at baseline to 7.9 at 5 years (p < 0.0001) with 53.2% RR. High-volume centers (>10 implantations) had 42.8% reduction in median monthly SF by 2 years in comparison with 25.8% in low-volume center. In patients with cognitive impairment, the reduction in median monthly SF was 26.0% by 2 years compared with 36.1% in patients without cognitive impairment. The most frequently reported adverse events were changes (e.g., increased frequency/severity) in seizure (16%), memory impairment (patient-reported complaint, 15%), depressive mood (patient-reported complaint, 13%), and epilepsy (12%). One definite sudden unexpected death in epilepsy case was reported. Discussion The MORE registry supports t

Published
2023
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27. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults

Author

Projectafdeling KIND, Neurologen, Brain, Ferreira-Atuesta, Carolina, de Tisi, Jane, McEvoy, Andrew W, Miserocchi, Anna, Khoury, Jean, Yardi, Ruta, Vegh, Deborah T, Butler, James, Lee, Hamin J, Deli-Peri, Victoria, Yao, Yi, Wang, Feng-Peng, Zhang, Xiao-Bin, Shakhatreh, Lubna, Siriratnam, Pakeeran, Neal, Andrew, Sen, Arjune, Tristram, Maggie, Varghese, Elizabeth, Biney, Wendy, Gray, William P, Peralta, Ana Rita, Rainha-Campos, Alexandre, Gonçalves-Ferreira, António J C, Pimentel, José, Arias, Juan Fernando, Terman, Samuel, Terziev, Robert, Lamberink, Herm J, Braun, Kees P J, Otte, Willem M, Rugg-Gunn, Fergus J, Gonzalez, Walter, Bentes, Carla, Hamandi, Khalid, O'Brien, Terence J, Perucca, Piero, Yao, Chen, Burman, Richard J, Jehi, Lara, Duncan, John S, Sander, Josemir W, Koepp, Matthias, Galovic, Marian, Projectafdeling KIND, Neurologen, Brain, Ferreira-Atuesta, Carolina, de Tisi, Jane, McEvoy, Andrew W, Miserocchi, Anna, Khoury, Jean, Yardi, Ruta, Vegh, Deborah T, Butler, James, Lee, Hamin J, Deli-Peri, Victoria, Yao, Yi, Wang, Feng-Peng, Zhang, Xiao-Bin, Shakhatreh, Lubna, Siriratnam, Pakeeran, Neal, Andrew, Sen, Arjune, Tristram, Maggie, Varghese, Elizabeth, Biney, Wendy, Gray, William P, Peralta, Ana Rita, Rainha-Campos, Alexandre, Gonçalves-Ferreira, António J C, Pimentel, José, Arias, Juan Fernando, Terman, Samuel, Terziev, Robert, Lamberink, Herm J, Braun, Kees P J, Otte, Willem M, Rugg-Gunn, Fergus J, Gonzalez, Walter, Bentes, Carla, Hamandi, Khalid, O'Brien, Terence J, Perucca, Piero, Yao, Chen, Burman, Richard J, Jehi, Lara, Duncan, John S, Sander, Josemir W, Koepp, Matthias, and Galovic, Marian

Published
2023

31. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug Resistant Epilepsy in the MORE Multicenter Patient Registry

Author

Peltola, Jukka, primary, Colon, Albert J., additional, Pimentel, José, additional, Coenen, Volker A., additional, Gil-Nagel, Antonio, additional, Ferreira, Antonio Gonçalves, additional, Lehtimäki, Kai, additional, Ryvlin, Philippe, additional, Taylor, Rod S., additional, Ackermans, Linda, additional, Ardesch, Jacqueline, additional, Bentes, Carla, additional, Bosak, Magdalena, additional, Burneo, Jorge G., additional, Chamadoira, Clara, additional, Elger, Christian E., additional, Erőss, Loránd, additional, Fabo, Dániel, additional, Faulkner, Howard, additional, Gawlowicz, Jacek, additional, Gharabaghi, Alireza, additional, Iacoangeli, Maurizio, additional, Janszky, Jozsef, additional, Järvenpää, Soila, additional, Kaufmann, Elisabeth, additional, Kho, Kuan H, additional, Kumlien, Eva, additional, Laufs, Helmut, additional, Lettieri, Christian, additional, Linhares, Paulo, additional, Noachtar, Soheyl, additional, Parrent, Andrew, additional, Pataraia, Ekaterina, additional, Patel, Nikunj K, additional, Peralta, Ana Rita, additional, Rácz, Attila, additional, Campos, Alexandre Rainha, additional, Rego, Ricardo, additional, Ricciuti, Riccardo A., additional, Rona, Sabine, additional, Rouhl, Rob P.W., additional, Schulze-Bonhage, Andreas, additional, Schuurman, Rick, additional, Sprengers, Mathieu, additional, Sufianov, Albert, additional, Temel, Yasin, additional, Theys, Tom, additional, Van Paesschen, Wim, additional, Van Roost, Dirk, additional, Vaz, Rui, additional, Vonck, Kristl, additional, Wagner, Louis, additional, Zwemmer, Jack, additional, Abouihia, Abdallah, additional, Brionne, Thomas C., additional, Gielen, Frans, additional, and Boon, Paul A. J. M., additional

Published
2023
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37. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults

Author

Ferreira-Atuesta, Carolina, primary, de Tisi, Jane, additional, McEvoy, Andrew W, additional, Miserocchi, Anna, additional, Khoury, Jean, additional, Yardi, Ruta, additional, Vegh, Deborah T, additional, Butler, James, additional, Lee, Hamin J, additional, Deli-Peri, Victoria, additional, Yao, Yi, additional, Wang, Feng-Peng, additional, Zhang, Xiao-Bin, additional, Shakhatreh, Lubna, additional, Siriratnam, Pakeeran, additional, Neal, Andrew, additional, Sen, Arjune, additional, Tristram, Maggie, additional, Varghese, Elizabeth, additional, Biney, Wendy, additional, Gray, William P, additional, Peralta, Ana Rita, additional, Rainha-Campos, Alexandre, additional, Gonçalves-Ferreira, António J C, additional, Pimentel, José, additional, Arias, Juan Fernando, additional, Terman, Samuel, additional, Terziev, Robert, additional, Lamberink, Herm J, additional, Braun, Kees P J, additional, Otte, Willem M, additional, Rugg-Gunn, Fergus J, additional, Gonzalez, Walter, additional, Bentes, Carla, additional, Hamandi, Khalid, additional, O'Brien, Terence J, additional, Perucca, Piero, additional, Yao, Chen, additional, Burman, Richard J, additional, Jehi, Lara, additional, Duncan, John S, additional, Sander, Josemir W, additional, Koepp, Matthias, additional, and Galovic, Marian, additional

Published
2022
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43. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke

Author

Mishra, Nishant K., primary, Engel, Jerome, additional, Liebeskind, David S., additional, Sharma, Vijay K., additional, Hirsch, Lawrence J., additional, Kasner, Scott E, additional, French, Jacqueline A., additional, Devinsky, Orrin, additional, Friedman, Alon, additional, Dawson, Jesse, additional, Quinn, Terence J., additional, Selim, Magdy, additional, de Havenon, Adam, additional, Yasuda, Clarissa L., additional, Cendes, Fernando, additional, Benninger, Felix, additional, Zaveri, Hitten P., additional, Burneo, Jorge G., additional, Srivastava, Padma, additional, Bhushan Singh, Mamta, additional, Bhatia, Rohit, additional, Vishnu, V.Y., additional, Bentes, Carla, additional, Ferro, Jose, additional, Weiss, Shennan, additional, Sivaraju, Adithya, additional, Kim, Jennifer A., additional, Galovic, Marian, additional, Gilmore, Emily J., additional, Pitkänen, Asla, additional, Davis, Kathryn, additional, Sansing, Lauren H., additional, Sheth, Kevin N., additional, Paz, Jeanne T., additional, Singh, Anuradha, additional, Sheth, Sunil, additional, Worrall, Bradford B., additional, Grotta, James C., additional, Casillas-Espinos, Pablo M., additional, Chen, Zhibin, additional, Nicolo, John-Paul, additional, Yan, Bernard, additional, and Kwan, Patrick, additional

Published
2022
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46. Sleep and awakening quality during COVID-19 confinement

Author

Paiva, Teresa, Reis, Cátia, Feliciano, Amélia, Canas-Simião, Hugo, Machado, Maria Augusta, Gaspar, Tânia, Tomé, Gina, Branquinho, Cátia, Silva, Maria Raquel, Ramiro, Lúcia, Gaspar, Susana, Bentes, Carla, Sampaio, Francisco, Pinho, Lara, Pereira, Conceição, Carreiro, Alexandra, Moreira, Susana, Luzeiro, Isabel, Pimentel, Joana, Videira, Gabriela, Fonseca, Júlio, Bernarda, Ana, Castro, Joana Vaz, Rebocho, Sofia, Almondes, Katie, Canhão, Helena, Matos, Margarida Gaspar, Comprehensive Health Research Centre (CHRC) - pólo NMS, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Health-related behaviors, SDG 3 - Good Health and Well-being, Health, Attitudes, Health, Toxicology and Mutagenesis, Mood, Public Health, Environmental and Occupational Health, COVID-19, Dependences, Health professionals, Sleep patients, Sleep/awakening quality, Calamity Experience Check List
Abstract

Acknowledgments: Gina Tomé is a postdoctorate funded by the Fundação Ciência e Tecnologia (FCT) SFRH/BPD/108637/2015. Objective: The aim of this study was to evaluate sleep and awakening quality (SQ and AQ) during COVID-19 in a large and diversified population in order to identify significant associations and risks in terms of demography, health and health-related behaviors, sleep variables, mental health, and attitudes. Methods/Results:Online surveys were used for data collection, received from 5479 individuals from the general population, sleep disorder patients, and COVID-involved (medical doctors (MDs) and nurses) and COVID-affected professionals (teachers, psychologists, and dentists). SQ and AQ were worse in adults, females, and high-education subjects. Feeling worse, having economic problems, depression, anxiety, irritability, and a high Calamity Experience Check List (CECL) score during COVID were significantly associated with poor SQ and AQ. Shorter sleep duration, increased latency, poor nutrition, low physical activity, increased mobile and social network use, more negative and less positive attitudes and behaviors were associated with poor AQ. Conclusions: The SQ logistic regression showed gender, morbidities, CECL, and awakenings as relevant, whereas, for AQ, relevant variables further included age and physical activity. Aiming to have a high stress compliance, each individual should sleep well, have important control of their mood, practice positive behaviors while dismissing negative behaviors and attitudes, practice exercise, have adequate nutrition, and beware of technologies and dependences. publishersversion published

Published
2021

47. Seizures after Ischemic Stroke: A Matched Multicenter Study

Author

Ferreira‐Atuesta, Carolina, primary, Döhler, Nico, additional, Erdélyi‐Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Scherrer, Natalie, additional, Bicciato, Giulio, additional, Schweizer, Juliane, additional, Sinka, Lucia, additional, Imbach, Lukas L., additional, Katan, Mira, additional, Abraira, Laura, additional, Santamarina, Estevo, additional, Álvarez‐Sabín, José, additional, Winklehner, Michael, additional, von Oertzen, Tim J., additional, Wagner, Judith N., additional, Gigli, Gian Luigi, additional, Serafini, Anna, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Gregoraci, Giorgia, additional, Conrad, Julian, additional, Evers, Stefan, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Ana Rita, additional, Melo, Teresa Pinho e, additional, Keezer, Mark R., additional, Duncan, John S., additional, Sander, Josemir W., additional, Tettenborn, Barbara, additional, Koepp, Matthias J., additional, and Galovic, Marian, additional

Published
2021
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49. Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management

Author

Galovic, Marian; https://orcid.org/0000-0002-2307-071X, Ferreira-Atuesta, Carolina, Abraira, Laura, Döhler, Nico, Sinka, Lucia, Brigo, Francesco, Bentes, Carla, Zelano, Johan, Koepp, Matthias J, Galovic, Marian; https://orcid.org/0000-0002-2307-071X, Ferreira-Atuesta, Carolina, Abraira, Laura, Döhler, Nico, Sinka, Lucia, Brigo, Francesco, Bentes, Carla, Zelano, Johan, and Koepp, Matthias J

Abstract

Stroke is the leading cause of seizures and epilepsy in older adults. Patients who have larger and more severe strokes involving the cortex, are younger, and have acute symptomatic seizures and intracerebral haemorrhage are at highest risk of developing post-stroke epilepsy. Prognostic models, including the SeLECT and CAVE scores, help gauge the risk of epileptogenesis. Early electroencephalogram and blood-based biomarkers can provide information additional to the clinical risk factors of post-stroke epilepsy. The management of acute versus remote symptomatic seizures after stroke is markedly different. The choice of an ideal antiseizure medication should not only rely on efficacy but also consider adverse effects, altered pharmacodynamics in older adults, and the influence on the underlying vascular co-morbidity. Drug-drug interactions, particularly those between antiseizure medications and anticoagulants or antiplatelets, also influence treatment decisions. In this review, we describe the epidemiology, risk factors, biomarkers, and management of seizures after an ischaemic or haemorrhagic stroke. We discuss the special considerations required for the treatment of post-stroke epilepsy due to the age, co-morbidities, co-medication, and vulnerability of stroke survivors.

Published
2021

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