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549 results on '"Benseler, Susanne M."'

2. Uncovering the hidden socioeconomic impact of juvenile idiopathic arthritis and paving the way for other rare childhood diseases: an international, cross-disciplinary, patient-centered approach (PAVE Consortium)

Author

Marshall, Deborah A., Gerber, Brittany, Currie, Gillian R., Antón, Jordi, De Somer, Lien, Dey, Michelle, Egert, Tsipi, Egert, Yona, Henan, Lia, Klotsche, Jens, Mifsut, Laura Martinez, Minden, Kirsten, Normand, Christophe, Porte, David, Saurenmann, Rotraud K., Swart, Joost F., Uziel, Yosef, Wilson, Jennifer, Wouters, Carine, Ziv, Amit, and Benseler, Susanne M.

Published
2024
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3. Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage

Author

El Tal, Tala, Morin, Marie-Paule, Morris, Shaun K., Farrar, Daniel S., Berard, Roberta A., Kakkar, Fatima, Moore Hepburn, Charlotte, Baerg, Krista, Beaufils, Camille, Bennett, Terri-Lyn, Benseler, Susanne M., Beaudoin-Bussières, Guillaume, Chan, Kevin, Cyr, Claude, Dahdah, Nagib, Donner, Elizabeth J., Drouin, Olivier, Edjoc, Rojiemiahd, Eljaouhari, Maryem, Embree, Joanne E., Farrell, Catherine, Finzi, Andrés, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin Thibodeau, Melanie, Lang, Bianca, Laxer, Ronald M., Luu, Thuy Mai, McCrindle, Brian W., Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Proulx-Gauthier, Jean-Philippe, Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Thibeault, Roseline, Top, Karina A., Viel-Thériault, Isabelle, Haddad, Elie, Scuccimarri, Rosie, and Yeung, Rae S. M.

Published
2023
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12. Real-World Biomarkers for Pediatric Takayasu Arteritis.

Author

Peremans, Lieselot, Twilt, Marinka, Benseler, Susanne M., Grisaru, Silviu, Kirton, Adam, Myers, Kimberly A., and Hamiwka, Lorraine

Subjects
TAKAYASU arteritis, BIOMARKERS, MAGNETIC resonance angiography, DIAGNOSTIC imaging, DIAGNOSIS, CHILDREN'S literature
Abstract

Childhood-onset Takayasu arteritis (TA) is a rare, heterogeneous disease with limited diagnostic markers. Our objective was to identify and classify all candidates for biomarkers of TA diagnosis in children reported in the literature. A systematic literature review (PRISMA) of MEDLINE, EMBASE, Wiley Cochrane Library, ClinicalTrias.gov, and WHO ICTRP for articles related to TA in the pediatric age group between January 2000 and August 2023 was performed. Data on demographics, clinical features, laboratory measurements, diagnostic imaging, and genetic analysis were extracted. We identified 2026 potential articles, of which 52 studies (81% case series) met inclusion criteria. A total of 1067 TA patients were included with a peak onset between 10 and 15 years. Childhood-onset TA predominantly presented with cardiovascular, constitutional, and neurological symptoms. Laboratory parameters exhibited a low sensitivity and specificity. Imaging predominantly revealed involvement of the abdominal aorta and renal arteries, with magnetic resonance angiography (MRA) being the preferred imaging modality. Our review confirms the heterogeneous presentation of childhood-onset TA, posing significant challenges to recognition and timely diagnosis. Collaborative, multinational efforts are essential to better understand the natural course of childhood-onset TA and to identify accurate biomarkers to enhance diagnosis and disease management, ultimately improving patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Inter-Rater Reliability of the CASCADE Criteria

Author

Bernard, Timothy J, Beslow, Lauren A, Manco-Johnson, Marilyn J, Armstrong-Wells, Jennifer, Boada, Richard, Weitzenkamp, David, Hollatz, Amanda, Poisson, Sharon, Amlie-Lefond, Catherine, Lo, Warren, deVeber, Gabrielle, Goldenberg, Neil A, Dowling, Michael M, Roach, E Steve, Fullerton, Heather J, Benseler, Susanne M, Jordan, Lori C, Kirton, Adam, and Ichord, Rebecca N

Subjects
Allied Health and Rehabilitation Science, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Neurosciences, Stroke, Clinical Research, Cardiovascular, Pediatric, Prevention, Brain Disorders, Brain Ischemia, Cerebral Arterial Diseases, Child, Cross-Sectional Studies, Humans, Neuroimaging, Reproducibility of Results, attention, classification, cohort studies, consensus, incidence, pediatrics, risk factors, Cardiorespiratory Medicine and Haematology, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and purposeThere are limited data about the reliability of subtype classification in childhood arterial ischemic stroke, an issue that prompted the IPSS (International Pediatric Stroke Study) to develop the CASCADE criteria (Childhood AIS Standardized Classification and Diagnostic Evaluation). Our purpose was to determine the CASCADE criteria's reliability in a population of children with stroke.MethodsEight raters from the IPSS reviewed neuroimaging and clinical records of 64 cases (16 cases each) randomly selected from a prospectively collected cohort of 113 children with arterial ischemic stroke and classified them using the CASCADE criteria. Clinical data abstracted included history of present illness, risk factors, and acute imaging. Agreement among raters was measured by unweighted κ statistic.ResultsThe CASCADE criteria demonstrated a moderate inter-rater reliability, with an overall κ statistic of 0.53 (95% confidence interval [CI]=0.39-0.67). Cardioembolic and bilateral cerebral arteriopathy subtypes had much higher agreement (κ=0.84; 95% CI=0.70-0.99; and κ=0.90; 95% CI=0.71-1.00, respectively) than cases of aortic/cervical arteriopathy (κ=0.36; 95% CI=0.01-0.71), unilateral focal cerebral arteriopathy of childhood (FCA; κ=0.49; 95% CI=0.23-0.76), and small vessel arteriopathy of childhood (κ=-0.012; 95% CI=-0.04 to 0.01).ConclusionsThe CASCADE criteria have moderate reliability when used by trained and experienced raters, which suggests that it can be used for classification in multicenter pediatric stroke studies. However, the moderate reliability of the arteriopathic subtypes suggests that further refinement is needed for defining subtypes. Such revisions may reduce the variability in the literature describing risk factors, recurrence, and outcomes associated with childhood arteriopathy.

Published
2016

16. A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry

Author

Nguyen, Kelly, primary, Barsalou, Julie, additional, Basodan, Daniah, additional, Batthish, Michelle, additional, Benseler, Susanne M, additional, Berard, Roberta A, additional, Blanchette, Nicholas, additional, Boire, Gilles, additional, Bolaria, Roxana, additional, Bruns, Alessandra, additional, Cabral, David A, additional, Cameron, Bonnie, additional, Campillo, Sarah, additional, Cellucci, Tania, additional, Chan, Mercedes, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Chhabra, Amieleena, additional, Couture, Julie, additional, Dancey, Paul, additional, De Bruycker, Jean-Jacques, additional, Demirkaya, Erkan, additional, Dhalla, Muhammed, additional, Duffy, Ciarán M, additional, Feldman, Brian M, additional, Feldman, Debbie E, additional, Gerschman, Tommy, additional, Haddad, Elie, additional, Heale, Liane, additional, Herrington, Julie, additional, Houghton, Kristin, additional, Huber, Adam M, additional, Human, Andrea, additional, Johnson, Nicole, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Larché, Maggie, additional, Laxer, Ronald M, additional, LeBlanc, Claire M, additional, Lee, Jennifer J Y, additional, Levy, Deborah M, additional, Lim, Lillian, additional, Lim, Lily S H, additional, Luca, Nadia, additional, McGrath, Tara, additional, McMillan, Tamara, additional, Miettunen, Paivi M, additional, Morishita, Kimberly A, additional, Ng, Hon Yan, additional, Oen, Kiem, additional, Park, Jonathan, additional, Petty, Ross E, additional, Proulx-Gauthier, Jean-Philippe, additional, Ramsey, Suzanne, additional, Roth, Johannes, additional, Rosenberg, Alan M, additional, Rozenblyum, Evelyn, additional, Rumsey, Dax G, additional, Schmeling, Heinrike, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Shiff, Natalie J, additional, Silverman, Earl, additional, Soon, Gordon, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tam, Herman, additional, Tse, Shirley M, additional, Tucker, Lori B, additional, Turvey, Stuart, additional, Twilt, Marinka, additional, Duffy, Karen Watanabe, additional, Yeung, Rae S M, additional, and Guzman, Jaime, additional

Published
2023
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19. International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis

Author

Nosadini, Margherita, Thomas, Terrence, Eyre, Michael, Anlar, Banu, Armangue, Thais, Benseler, Susanne M., Cellucci, Tania, Deiva, Kumaran, Gallentine, William, Gombolay, Grace, Gorman, Mark P., Hacohen, Yael, Jiang, Yuwu, Lim, Byung Chan, Muscal, Eyal, Ndondo, Alvin, Neuteboom, Rinze, Rostásy, Kevin, Sakuma, Hiroshi, Sharma, Suvasini, Tenembaum, Silvia Noemi, Van Mater, Heather Ann, Wells, Elizabeth, Wickstrom, Ronny, Yeshokumar, Anusha K., Irani, Sarosh R., Dalmau, Josep, Lim, Ming, and Dale, Russell C.

Published
2021
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21. Towards a Consensus-Based Classification of Childhood Arterial Ischemic Stroke

Author

Bernard, Timothy J, Manco-Johnson, Marilyn J, Lo, Warren, MacKay, Mark T, Ganesan, Vijeya, deVeber, Gabrielle, Goldenberg, Neil A, Armstrong-Wells, Jennifer, Dowling, Michael M, Roach, E Steve, Tripputi, Mark, Fullerton, Heather J, Furie, Karen L, Benseler, Susanne M, Jordan, Lori C, Kirton, Adam, and Ichord, Rebecca

Subjects
Brain Disorders, Neurosciences, Pediatric, Stroke, Algorithms, Brain Ischemia, Cerebral Arterial Diseases, Child, Consensus, Delphi Technique, Humans, Observer Variation, Registries, Reproducibility of Results, pediatric, classification, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeThe implementation of uniform nomenclature and classification in adult arterial ischemic stroke (AIS) has been critical for defining outcomes and recurrence risks according to etiology and in developing risk-stratified treatments. In contrast, current classification and nomenclature in childhood AIS are often overlapping or contradictory. Our purpose was to develop a comprehensive consensus-based classification system for childhood AIS.MethodsUsing a modified-Delphi method, members of the International Pediatric Stroke Study (IPSS) developed the Childhood AIS Standardized Classification And Diagnostic Evaluation (CASCADE) criteria. Two groups of pediatric stroke specialists from the IPSS classified 7 test cases using 2 methods each: (1) classification typical of the individual clinician's current clinical practice; and (2) classification based on the CASCADE criteria. Group 1 underwent in-person training in the utilization of the CASCADE criteria. Group 2 classified the same cases via an online survey, including definitions but without training. Inter-rater reliability (IRR) was assessed via multi-rater unweighted κ-statistic.ResultsIn Group 1 (with training), IRR was improved using CASCADE criteria (κ=0.78, 95% CI=[0.49, 0.94]), compared with typical clinical practice (κ=0.40, 95% CI=[0.11, 0.60]). In Group 2 (without training), IRR was lower than among trained raters (κ=0.61, 95% CI=[0.29, 0.77]), but higher than current practice (κ=0.23, 95% CI=[0.03, 0.36]).ConclusionsA new, consensus-based classification system for childhood AIS, the CASCADE criteria, can be used to classify cases with good IRR. These preliminary findings suggest that the CASCADE criteria may be particularity useful in the setting of prospective multicenter studies in childhood-onset AIS, where standardized training of investigators is feasible.

Published
2012

25. Additional file 1 of Withdrawing biologics in non-systemic JIA: what matters to pediatric rheumatologists?

Author

van Til, Janine A., Kip, Michelle M. A., Schatorjé, Ellen J. H., Currie, Gillian, Twilt, Marinka, Benseler, Susanne M., Swart, Joost F., Vastert, Sebastiaan J., Wulffraat, Nico, Yeung, Rae S. M., Groothuis-Oudshoorn, C. G. M. (Karin), Warta, Sanne, Marshall, Deborah A., and IJzerman, Maarten J.

Abstract

Additional file 1. Results of interviews with pediatric rheumatologists.

Published
2023
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26. Additional file 4 of Withdrawing biologics in non-systemic JIA: what matters to pediatric rheumatologists?

Author

van Til, Janine A., Kip, Michelle M. A., Schatorjé, Ellen J. H., Currie, Gillian, Twilt, Marinka, Benseler, Susanne M., Swart, Joost F., Vastert, Sebastiaan J., Wulffraat, Nico, Yeung, Rae S. M., Groothuis-Oudshoorn, C. G. M. (Karin), Warta, Sanne, Marshall, Deborah A., and IJzerman, Maarten J.

Abstract

Additional file 4: Supplementary Table 2. The experimental design of the 16 clinical vignettes.

Published
2023
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27. Additional file 2 of Withdrawing biologics in non-systemic JIA: what matters to pediatric rheumatologists?

Author

van Til, Janine A., Kip, Michelle M. A., Schatorjé, Ellen J. H., Currie, Gillian, Twilt, Marinka, Benseler, Susanne M., Swart, Joost F., Vastert, Sebastiaan J., Wulffraat, Nico, Yeung, Rae S. M., Groothuis-Oudshoorn, C. G. M. (Karin), Warta, Sanne, Marshall, Deborah A., and IJzerman, Maarten J.

Abstract

Additional file 2: Survey Instrument.

Published
2023
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28. Additional file 8 of Withdrawing biologics in non-systemic JIA: what matters to pediatric rheumatologists?

Author

van Til, Janine A., Kip, Michelle M. A., Schatorjé, Ellen J. H., Currie, Gillian, Twilt, Marinka, Benseler, Susanne M., Swart, Joost F., Vastert, Sebastiaan J., Wulffraat, Nico, Yeung, Rae S. M., Groothuis-Oudshoorn, C. G. M. (Karin), Warta, Sanne, Marshall, Deborah A., and IJzerman, Maarten J.

Abstract

Additional file 8: Supplementary Table 6. Decision to continue biologic therapy dependent upon country. Supplementary Table 7. Treatment duration with biologic therapy dependent upon country.

Published
2023
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29. Additional file 6 of Withdrawing biologics in non-systemic JIA: what matters to pediatric rheumatologists?

Author

van Til, Janine A., Kip, Michelle M. A., Schatorjé, Ellen J. H., Currie, Gillian, Twilt, Marinka, Benseler, Susanne M., Swart, Joost F., Vastert, Sebastiaan J., Wulffraat, Nico, Yeung, Rae S. M., Groothuis-Oudshoorn, C. G. M. (Karin), Warta, Sanne, Marshall, Deborah A., and IJzerman, Maarten J.

Abstract

Additional file 6: Supplementary Table 4. Withdrawal of biologic therapy at each time interval in response to the clinical vignettes.

Published
2023
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30. Additional file 7 of Withdrawing biologics in non-systemic JIA: what matters to pediatric rheumatologists?

Author

van Til, Janine A., Kip, Michelle M. A., Schatorjé, Ellen J. H., Currie, Gillian, Twilt, Marinka, Benseler, Susanne M., Swart, Joost F., Vastert, Sebastiaan J., Wulffraat, Nico, Yeung, Rae S. M., Groothuis-Oudshoorn, C. G. M. (Karin), Warta, Sanne, Marshall, Deborah A., and IJzerman, Maarten J.

Abstract

Additional file 7: Supplementary Table 5. Perceived influence of other disease characteristics on the withdrawal decision.

Published
2023
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31. Additional file 3 of Withdrawing biologics in non-systemic JIA: what matters to pediatric rheumatologists?

Author

van Til, Janine A., Kip, Michelle M. A., Schatorjé, Ellen J. H., Currie, Gillian, Twilt, Marinka, Benseler, Susanne M., Swart, Joost F., Vastert, Sebastiaan J., Wulffraat, Nico, Yeung, Rae S. M., Groothuis-Oudshoorn, C. G. M. (Karin), Warta, Sanne, Marshall, Deborah A., and IJzerman, Maarten J.

Abstract

Additional file 3: Supplementary Table 1. Characteristics and levels inluded in the clinical vignettes.

Published
2023
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32. Additional file 5 of Withdrawing biologics in non-systemic JIA: what matters to pediatric rheumatologists?

Author

van Til, Janine A., Kip, Michelle M. A., Schatorjé, Ellen J. H., Currie, Gillian, Twilt, Marinka, Benseler, Susanne M., Swart, Joost F., Vastert, Sebastiaan J., Wulffraat, Nico, Yeung, Rae S. M., Groothuis-Oudshoorn, C. G. M. (Karin), Warta, Sanne, Marshall, Deborah A., and IJzerman, Maarten J.

Abstract

Additional file 5: Supplementary Table 3. Descriptive data for each of the 16 clinical vignettes.

Published
2023
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33. Inflammatory Brain Diseases

Author

Twilt, Marinka, Nita, Dragos A., Benseler, Susanne M., Wheeler, Derek S., editor, Wong, Hector R., editor, and Shanley, Thomas P., editor

Published
2014
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36. Health-related quality of life in children with inflammatory brain disease

Author

Liu, Elina, Twilt, Marinka, Tyrrell, Pascal N., Dropol, Anastasia, Sheikh, Shehla, Gorman, Mark, Kim, Susan, Cabral, David A., Forsyth, Rob, Van Mater, Heather, Li, Suzanne, Huber, Adam M., Stringer, Elizabeth, Muscal, Eyal, Wahezi, Dawn, Toth, Mary, Dolezalova, Pavla, Kobrova, Katerina, Ristic, Goran, and Benseler, Susanne M.

Published
2018
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38. PFAPA syndrome in children: Regional disparities and delay to the diagnosis

Author

Ellinghaus, Maren, Wasiliew, Peter, Michler, Christine, Stauch, Anette, Benseler, Susanne M., Kümmerle-Deschner, Jasmin B., and Welzel, Tatjana

Subjects
Medicine and health
Abstract

Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome in childhood [ref:1]. Although considered benign, the health-related quality of life of children and families is often dramatically impacted. Timely diagnosis [for full text, please go to the a.m. URL]

Published
2022
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39. Treat-to-target in Interleukin-1 mediated autoinflammatory diseases

Author

Welzel, Tatjana, Klotsche, Jens, Zapf, Beate Magdalena, Benseler, Susanne M., and Kuemmerle-Deschner, Jasmin B

Subjects
Medicine and health
Abstract

Introduction: Uncontrolled disease activity (DA) in Interleukin-1 mediated autoinflammatory diseases (IL-1 AID) is potential life-threatening. Therefore, treatment should achieve no/minimal DA to prevent morbidity and mortality. This study analyzes DA and treatment in IL-1 AID to evaluate the need [for full text, please go to the a.m. URL]

Published
2022
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42. Association Between HLA–DPB1 and Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Children.

Author

Gibson, Kristen M., Drögemöller, Britt I., Foell, Dirk, Benseler, Susanne M., Graham, Jinko, Hancock, Robert E. W., Luqmani, Raashid A., Cabral, David A., Brown, Kelly L., and Ross, Colin J.

Subjects
HLA-B27 antigen, GENETICS, INFLAMMATION, ANTINEUTROPHIL cytoplasmic antibodies, ALLELES, EUROPEANS, GENOME-wide association studies, PEROXIDASE, INTERFERONS, DISEASE susceptibility, DESCRIPTIVE statistics, ODDS ratio, VASCULITIS, CHILDREN
Abstract

Objective: Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is a rare, life‐threatening inflammation of blood vessels that can affect both adults and children. Compared to adult‐onset disease, AAV is especially rare in children, with an annual prevalence of 0.5–6.4 cases per million children. The etiology of AAV remains largely unknown, and both environmental and genetic factors are likely involved. The present study was undertaken to explore the genetic susceptibility factors recently identified in adult patients, including HLA–DP and HLA–DQ, in pediatric patients. Methods: We performed a genome‐wide association study of pediatric AAV in patients of European ancestry (n = 63 AAV cases, n = 315 population‐matched controls). Results: We identified a significant genetic association between pediatric AAV and the HLA–DPB1*04:01 allele (P = 1.5 × 10−8, odds ratio [OR] 3.5), with a stronger association observed in children with proteinase 3–ANCA positivity than in children with myeloperoxidase−ANCA positivity. Among the HLA alleles, the HLA–DPB1*04:01 allele was the most highly associated with AAV, although not significantly, in a follow‐up adult AAV cohort (P = 2.6 × 10−4, OR 0.4). T cell receptor and interferon signaling pathways were also shown to be enriched in the pediatric AAV cohort. Conclusion: The HLA–DPB1 locus showed an association with pediatric AAV, as similarly shown previously in adult AAV. Despite the difference in the age of onset, these findings suggest that childhood‐ and adult‐onset vasculitis share a common genetic predisposition. The identification of genetic variants contributing to AAV is an important step to improved classification tools and treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Pharmacological treatment patterns in patients with juvenile idiopathic arthritis in the Netherlands: a real-world data analysis

Author

Kip, Michelle M A, primary, de Roock, Sytze, additional, Currie, Gillian, additional, Marshall, Deborah A, additional, Grazziotin, Luiza R, additional, Twilt, Marinka, additional, Yeung, Rae S M, additional, Benseler, Susanne M, additional, Vastert, Sebastiaan J, additional, Wulffraat, Nico, additional, Swart, Joost F, additional, and IJzerman, Maarten J, additional

Published
2022
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48. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study

Author

Titulaer, Maarten J, McCracken, Lindsey, Gabilondo, Iñigo, Armangué, Thaís, Glaser, Carol, Iizuka, Takahiro, Honig, Lawrence S, Benseler, Susanne M, Kawachi, Izumi, Martinez-Hernandez, Eugenia, Aguilar, Esther, Gresa-Arribas, Núria, Ryan-Florance, Nicole, Torrents, Abiguei, Saiz, Albert, Rosenfeld, Myrna R, Balice-Gordon, Rita, Graus, Francesc, and Dalmau, Josep

Published
2013
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49. Additional file 1 of Real-world data reveals the complexity of disease modifying anti-rheumatic drug treatment patterns in juvenile idiopathic arthritis: an observational study

Author

Grazziotin, Luiza R., Currie, Gillian, Twilt, Marinka, Ijzerman, Maarten J., Kip, Michelle M. A., Koffijberg, Hendrik, Benseler, Susanne M., Swart, Joost F., Vastert, Sebastiaan J., Wulffraat, Nico M., Yeung, Rae S. M., and Marshall, Deborah A.

Subjects
musculoskeletal diseases, immune system diseases, skin and connective tissue diseases
Abstract

Additional file 1: Figure S1. Inverted Kaplan-Meier showing time (years) from first visit to the Pediatric Rheumatology Clinic to A) start the first c-DMARD and B) start the first b-DMARD.

Published
2022
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