290 results on '"Bensch F"'
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2. Blunt cerebrovascular injuries in the craniofacial fracture population—Are we screening the right patients?
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Puolakkainen, T., Vähäsilta, L., Bensch, F., Narjus-Sterba, M., Wilson, M.L., Thorén, H., and Snäll, J.
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- 2021
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3. Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer.
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Eisses, Bertha, van Geel, Jasper J.L., Brouwers, Adrienne H., Bensch, Frederike, Elias, Sjoerd G., Kuip, Evelien J.M., Jager, Agnes, van der Vegt, Bert, Lub-de Hooge, Marjolijn N., Emmering, Jasper, Arens, Anne I.J., Zwezerijnen, Gerben J.C., Vugts, Daniëlle J., Menke-van der Houven van Oordt, C. Willemien, de Vries, Elisabeth G.E., Schröder, Carolina P., Bensch, F., van Es, S., van Essen-Eisses, B., and Boers, J.
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- 2024
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4. Photon Dominated Regions in NGC 3603
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Röllig, M., Kramer, C., Rajbahak, C., Minamidani, T., Sun, K., Simon, R., Ossenkopf, V., Cubick, M., Hitschfeld, M., Aravena, M., Bensch, F., Bertoldi, F., Bronfman, L., Fujishita, M., Fukui, Y., Graf, U. U., Honingh, N., Ito, S., Jakob, H., Jacobs, K., Klein, U., Koo, B. -C., May, J., Miller, M., Miyamoto, Y., Mizuno, N., Onishi, T., Park, Y. -S., Pineda, J., Rabanus, D., Sasago, H., Schieder, R., Stutzki, J., Yamamoto, H., and Yonekura, Y.
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Astrophysics - Galaxy Astrophysics - Abstract
Aims: We aim at deriving the excitation conditions of the interstellar gas as well as the local FUV intensities in the molecular cloud surrounding NGC 3603 to get a coherent picture of how the gas is energized by the central stars. Methods: The NANTEN2-4m submillimeter antenna is used to map the [CI] 1-0, 2-1 and CO 4-3, 7-6 lines in a 2' x 2' region around the young OB cluster NGC 3603 YC. These data are combined with C18O 2-1 data, HIRES-processed IRAS 60 and 100 micron maps of the FIR continuum, and Spitzer/IRAC maps. Results: The NANTEN2 observations show the presence of two molecular clumps located south-east and south-west of the cluster and confirm the overall structure already found by previous CS and C18O observations. We find a slight position offset of the peak intensity of CO and [CI], and the atomic carbon appears to be further extended compared to the molecular material. We used the HIRES far-infrared dust data to derive a map of the FUV field heating the dust. We constrain the FUV field to values of \chi = 3 - 6 \times 10^3 in units of the Draine field across the clouds. Approximately 0.2 to 0.3 % of the total FUV energy is re-emitted in the [CII] 158 {\mu}m cooling line observed by ISO. Applying LTE and escape probability calculations, we derive temperatures (TMM1 = 43 K, TMM2 = 47 K), column densities (N(MM1) = 0.9 \times 10^22 cm^-2, N(MM2) = 2.5 \times 10^22 cm^-2) and densities (n(MM1) = 3 \times 10^3 cm^-3, n(MM2) = 10^3 -10^4 cm^-3) for the two observed molecular clumps MM1 and MM2. Conclusions: The cluster is strongly interacting with the ambient molecular cloud, governing its structure and physical conditions. A stability analysis shows the existence of gravitationally collapsing gas clumps which should lead to star formation. Embedded IR sources have already been observed in the outskirts of the molecular cloud and seem to support our conclusions., Comment: 13 pages, 10 figures, accepted for publication by A&A
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- 2010
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5. First results on Martian carbon monoxide from Herschel/HIFI observations
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Hartogh, P., Błęcka, M. I., Jarchow, C., Sagawa, H., Lellouch, E., de Val-Borro, M., Rengel, M., Medvedev, A. S., Swinyard, B. M., Moreno, R., Cavalié, T., Lis, D. C., Banaszkiewicz, M., Bockelée-Morvan, D., Crovisier, J., Encrenaz, T., Küppers, M., Lara, L. -M., Szutowicz, S., Vandenbussche, B., Bensch, F., Bergin, E. A., Billebaud, F., Biver, N., Blake, G. A., Blommaert, J. A. D. L., Cernicharo, J., Decin, L., Encrenaz, P., Feuchtgruber, H., Fulton, T., de Graauw, T., Jehin, E., Kidger, M., Lorente, R., Naylor, D. A., Portyankina, G., Sánchez-Portal, M., Schieder, R., Sidher, S., Thomas, N., Verdugo, E., Waelkens, C., Lorenzani, A., Tofani, G., Natale, E., Pearson, J., Klein, T., Leinz, C., Güsten, R., and Kramer, C.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report on the initial analysis of Herschel/HIFI carbon monoxide (CO) observations of the Martian atmosphere performed between 11 and 16 April 2010. We selected the (7-6) rotational transitions of the isotopes ^{13}CO at 771 GHz and C^{18}O at 768 GHz in order to retrieve the mean vertical profile of temperature and the mean volume mixing ratio of carbon monoxide. The derived temperature profile agrees within less than 5 K with general circulation model (GCM) predictions up to an altitude of 45 km, however, show about 12-15 K lower values at 60 km. The CO mixing ratio was determined as 980 \pm 150 ppm, in agreement with the 900 ppm derived from Herschel/SPIRE observations in November 2009., Comment: Accepted for publication in Astronomy and Astrophysics (special issue on HIFI first results); minor changes to match published version
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- 2010
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6. Herschel/HIFI observations of Mars: first detection of O_2 at submillimetre wavelengths and upper limits on HCl and H_2O_2
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Hartogh, P., Jarchow, C., Lellouch, E., de Val-Borro, M., Rengel, M., Moreno, R., Medvedev, A. S., Sagawa, H., Swinyard, B. M., Cavalié, T., Lis, D. C., Błęcka, M. I., Banaszkiewicz, M., Bockelée-Morvan, D., Crovisier, J., Encrenaz, T., Küppers, M., Lara, L. -M., Szutowicz, S., Vandenbussche, B., Bensch, F., Bergin, E. A., Billebaud, F., Biver, N., Blake, G. A., Blommaert, J. A. D. L., Cernicharo, J., Decin, L., Encrenaz, P., Feuchtgruber, H., Fulton, T., de Graauw, T., Jehin, E., Kidger, M., Lorente, R., Naylor, D. A., Portyankina, G., Sánchez-Portal, M., Schieder, R., Sidher, S., Thomas, N., Verdugo, E., Waelkens, C., Whyborn, N., Teyssier, D., Helmich, F., Roelfsema, P., Stutzki, J., LeDuc, H. G., and Stern, J. A.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report on an initial analysis of Herschel/HIFI observations of hydrogen chloride (HCl), hydrogen peroxide (H_2O_2), and molecular oxygen (O_2) in the Martian atmosphere performed on 13 and 16 April 2010 (L_s ~ 77{\deg}). We derived a constant volume mixing ratio of 1400 +/- 120 ppm for O_2 and determined upper limits of 200 ppt for HCl and 2 ppb for H_2O_2. Radiative transfer model calculations indicate that the vertical profile of O_2 may not be constant. Photochemical models determine the lowest values of H_2O_2 to be around L_s ~ 75{\deg} but overestimate the volume mixing ratio compared to our measurements., Comment: Accepted for publication in Astronomy and Astrophysics (special issue on HIFI first results); minor changes to match published version
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- 2010
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7. Water production in comet 81P/Wild 2 as determined by Herschel/HIFI
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de Val-Borro, M., Hartogh, P., Crovisier, J., Bockelée-Morvan, D., Biver, N., Lis, D. C., Moreno, R., Jarchow, C., Rengel, M., Szutowicz, S., Banaszkiewicz, M., Bensch, F., Błęcka, M. I., Emprechtinger, M., Encrenaz, T., Jehin, E., Küppers, M., Lara, L. -M., Lellouch, E., Swinyard, B. M., Vandenbussche, B., Bergin, E. A., Blake, G. A., Blommaert, J. A. D. L., Cernicharo, J., Decin, L., Encrenaz, P., de Graauw, T., Hutsemékers, D., Kidger, M., Manfroid, J., Medvedev, A. S., Naylor, D. A., Schieder, R., Stam, D., Thomas, N., Waelkens, C., Szczerba, R., Saraceno, P., Di Giorgio, A. M., Philipp, S., Klein, T., Ossenkopf, V., Zaal, P., and Shipman, R.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The high spectral resolution and sensitivity of Herschel/HIFI allows for the detection of multiple rotational water lines and accurate determinations of water production rates in comets. In this letter we present HIFI observations of the fundamental 110-101 (557 GHz) ortho and 111-000 (1113 GHz) para rotational transitions of water in comet 81P/Wild 2 acquired in February 2010. We mapped the extent of the water line emission with five point scans. Line profiles are computed using excitation models which include excitation by collisions with electrons and neutrals and solar infrared radiation. We derive a mean water production rate of $1.0 \times 10^{28}$ molecules s$^{-1}$ at a heliocentric distance of 1.61 AU about 20 days before perihelion, in agreement with production rates measured from the ground using observations of the 18-cm OH lines. Furthermore, we constrain the electron density profile and gas kinetic temperature, and estimate the coma expansion velocity by fitting the water line shapes., Comment: Accepted for publication in A&A (special issue on HIFI first results)
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- 2010
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8. First results of Herschel/PACS observations of Neptune
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Lellouch, E., Hartogh, P., Feuchtgruber, H., Vandenbussche, B., de Graauw, T., Moreno, R., Jarchow, C., Cavalié, T., Orton, G., Banaszkiewicz, M., Blecka, M. I., Bockelée-Morvan, D., Crovisier, J., Encrenaz, T., Fulton, T., Küppers, M., Lara, L. M., Lis, D. C., Medvedev, A. S., Rengel, M., Sagawa, H., Swinyard, B., Szutowicz, S., Bensch, F., Bergin, E., Billebaud, F., Biver, N., Blake, G. A., Blommaert, J. A. D. L., Cernicharo, J., Courtin, R., Davis, G. R., Decin, L., Encrenaz, P., Gonzalez, A., Jehin, E., Kidger, M., Naylor, D., Portyankina, G., Schieder, R., Sidher, S., Thomas, N., de Val-Borro, M., Verdugo, E., Waelkens, C., Walker, H., Aarts, H., Comito, C., Kawamura, J. H., Maestrini, A., Peacocke, T., Teipen, R., Tils, T., and Wildeman, K.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report on the initial analysis of a Herschel/PACS full range spectrum of Neptune, covering the 51-220 micrometer range with a mean resolving power of ~ 3000, and complemented by a dedicated observation of CH4 at 120 micrometers. Numerous spectral features due to HD (R(0) and R(1)), H2O, CH4, and CO are present, but so far no new species have been found. Our results indicate that (i) Neptune's mean thermal profile is warmer by ~ 3 K than inferred from the Voyager radio-occultation; (ii) the D/H mixing ratio is (4.5+/-1) X 10**-5, confirming the enrichment of Neptune in deuterium over the protosolar value (~ 2.1 X 10**-5); (iii) the CH4 mixing ratio in the mid stratosphere is (1.5+/-0.2) X 10**-3, and CH4 appears to decrease in the lower stratosphere at a rate consistent with local saturation, in agreement with the scenario of CH4 stratospheric injection from Neptune's warm south polar region; (iv) the H2O stratospheric column is (2.1+/-0.5) X 10**14 cm-2 but its vertical distribution is still to be determined, so the H2O external flux remains uncertain by over an order of magnitude; and (v) the CO stratospheric abundance is about twice the tropospheric value, confirming the dual origin of CO suspected from ground-based millimeter/submillimeter observations., Comment: Accepted for publication in Astronomy & Astrophysics (special issue on Herschel first results)
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- 2010
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9. The Herschel-SPIRE submillimetre spectrum of Mars
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Swinyard, B. M., Hartogh, P., Sidher, S., Fulton, T., Lellouch, E., Jarchow, C., Griffin, M. J., Moreno, R., Sagawa, H., Portyankina, G., Blecka, M., Banaszkiewicz, M., Bockelee-Morvan, D., Crovisier, J., Encrenaz, T., Kueppers, M., Lara, L., Lis, D., Medvedev, A., Renge, M., Szutowicz, S., Vandenbussche, B., Bensch, F., Bergin, E., Billebaud, F., Biver, N., Blake, G., Blommaert, J., de Val-Borro, M., Cernicharo, J., Cavalie, T., Courtin, R., Davis, G., Decin, L., Encrenaz, P., de Graauw, T., Jehin, E., Kidger, M., Leeks, S., Orton, G., Naylor, D., Schieder, R., Stam, D., Thomas, N., Verdugo, E., Waelkens, C., and Walker, H.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We have obtained the first continuous disk averaged spectrum of Mars from 450 to 1550 Ghz using the Herschel-SPIRE Fourier Transform Spectrometer. The spectrum was obtained at a constant resolution of 1.4 GHz across the whole band. The flux from the planet is such that the instrument was operated in "bright source" mode to prevent saturation of the detectors. This was the first successful use of this mode and in this work we describe the method used for observing Mars together with a detailed discussion of the data reduction techniques required to calibrate the spectrum. We discuss the calibration accuracy obtained and describe the first comparison with surface and atmospheric models. In addition to a direct photometric measurement of the planet the spectrum contains the characteristic transitions of 12CO from J 5-4 to J 13-12 as well as numerous H2O transitions. Together these allow the comparison to global atmospheric models allowing the mean mixing ratios of water and 12CO to be investigated. We find that it is possible to match the observed depth of the absorption features in the spectrum with a fixed water mixing ratio of 1 x 10-4 and a 12CO mixing ratio of 9 x 10-4, Comment: Accepted for publication in Astronomy&Astrophysics, Herschel First Results special issue
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- 2010
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10. HIFI Observations of Water in the Atmosphere of Comet C/2008 Q3 (Garradd)
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Hartogh, P., Crovisier, J., de Val-Borro, M., Bockelée-Morvan, D., Biver, N., Lis, D. C., Moreno, R., Jarchow, C., Rengel, M., Emprechtinger, M., Szutowicz, S., Banaszkiewicz, M., Bensch, F., Blecka, M. I., Cavalié, T., Encrenaz, T., Jehin, E., Küppers, M., Lara, L. -M., Lellouch, E., Swinyard, B. M., Vandenbussche, B., Bergin, E. A., Blake, G. A., Blommaert, J. A. D. L., Cernicharo, J., Decin, L., Encrenaz, P., de Graauw, T., Hutsemekers, D., Kidger, M., Manfroid, J., Medvedev, A. S., Naylor, D. A., Schieder, R., Thomas, N., Waelkens, C., Roelfsema, P. R., Dieleman, P., Guesten, R., Klein, T., Kasemann, C., Caris, M., Olberg, M., and Benz, A. O.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
High-resolution far-infrared and sub-millimetre spectroscopy of water lines is an important tool to understand the physical and chemical properties of cometary atmospheres. We present observations of several rotational ortho- and para-water transitions in comet C/2008 Q3 (Garradd) performed with HIFI on Herschel. These observations have provided the first detection of the 2_{12}-1_{01} (1669 GHz) ortho and 1_{11}-0_{00} (1113 GHz) para transitions of water in a cometary spectrum. In addition, the ground-state transition 1_{10}-1_{01} at 557 GHz is detected and mapped. By detecting several water lines quasi-simultaneously and mapping their emission we can constrain the excitation parameters in the coma. Synthetic line profiles are computed using excitation models which include excitation by collisions, solar infrared radiation, and radiation trapping. We obtain the gas kinetic temperature, constrain the electron density profile, and estimate the coma expansion velocity by analyzing the map and line shapes. We derive water production rates of 1.7-2.8 x 10^{28} s^{-1} over the range r_h = 1.83-1.85 AU., Comment: 7 figures, v2: minor changes, updated version of arXiv:1005.2969v1. Accepted for publication in Astronomy and Astrophysics, Herschel special issue on Herschel First Science Results
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- 2010
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11. A study of the distant activity of comet C/2006 W3 (Christensen) using Herschel and ground-based radio telescopes
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Bockelée-Morvan, D., Hartogh, P., Crovisier, J., Vandenbussche, B., Swinyard, B. M., Biver, N., Lis, D. C., Jarchow, C., Moreno, R., Hutsemékers, D., Jehin, E., Küppers, M. K., Lara, L. M., Lellouch, E., Manfroid, J., de Val-Borro, M., Szutowicz, S., Banaszkiewicz, M., Bensch, F., Blecka, M. I., Emprechtinger, M., Encrenaz, T., Fulton, T., Kidger, M., Rengel, M., Waelkens, C., Bergin, E., Blake, G. A., Blommaert, J. A. D. L., Cernicharo, J., Decin, L., Encrenaz, P., de Graauw, T., Leeks, S., Medvedev, A. S., Naylor, D., Schieder, R., and Thomas, N.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Comet C/2006 W3 (Christensen) was observed in November 2009 at 3.3 AU from the Sun with Herschel. The PACS instrument acquired images of the dust coma in 70- and 160-micrometers filters, and spectra covering several H2O rotational lines. Spectra in the range 450-1550 GHz were acquired with SPIRE. The comet emission continuum from 70 to 672 micrometers was measured, but no lines were detected. The spectral energy distribution indicates thermal emission from large particles and provides a measure of the size distribution index and dust production rate. The upper limit to the water production rate is compared to the production rates of other species (CO, CH3OH, HCN, H2S, OH) measured with the IRAM 30-m and Nancay telescopes. The coma is found to be strongly enriched in species more volatile than water, in comparison to comets observed closer to the Sun. The CO to H2O production rate ratio exceeds 220%. The dust to gas production rate ratio is on the order of 1., Comment: Accepted for publication in Astronomy & Astrophysics (special issue on Herschel first results)
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- 2010
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12. Submillimeter Line Emission from LMC N159W: a Dense, Clumpy PDR in a Low Metallicity Environment
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Pineda, J. L., Mizuno, N., Stutzki, J., Cubick, M., Aravena, M., Bensch, F., Bertoldi, F., Bronfman, L., Fujishita, K., Graf, U. U., Hitschfeld, M., Honingh, N., Jakob, H., Jacobs, K., Kawamura, A., Klein, U., Kramer, C., May, J., Miller, M., Mizuno, Y., Müller, P., Onishi, T., Ossenkopf, V., Rabanus, D., Röllig, M., Rubio, M., Sasago, H., Schieder, R., Simon, R., Sun, K., Volgenau, N., Yamamoto, H., and Fukui, Y.
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Astrophysics - Abstract
Star formation at earlier cosmological times takes place in an interstellar medium with low metallicity. The Large Magellanic Cloud (LMC) is ideally suited to study star formation in such an environment. The physical and chemical state of the ISM in a star forming environment can be constrained by observations of submm and FIR spectral lines of the main carbon carrying species, CO, CI and CII, which originate in the surface layers of molecular clouds illuminated by the UV radiation of the newly formed, young stars. We present high-angular resolution sub-millimeter observations in the N159W region in the LMC obtained with the NANTEN2 telescope of the 12CO J = 4-3, J = 7-6, and 13CO J = 4-3 rotational and [CI] 3P1-3P0 and 3P2-3P1 fine-structure transitions. The 13CO J =4-3 and [CI] 3P2-3P1 transitions are detected for the first time in the LMC. We derive the physical and chemical properties of the low-metallicity molecular gas using an escape probability code and a self-consistent solution of the chemistry and thermal balance of the gas in the framework of a clumpy cloud PDR model. The separate excitation analysis of the submm CO lines and the carbon fine structure lines shows that the emitting gas in the N159W region has temperatures of about 80 K and densities of about 10^4 cm^-3. The estimated C to CO abundance ratio close to unity is substantially higher than in dense massive star-forming regions in the Milky Way. The analysis of all observed lines together, including the [CII] line intensity reported in the literature, in the context of a clumpy cloud PDR model constrains the UV intensity to about \chi ~220 and an average density of the clump ensemble of about 10^5 cm^-3, thus confirming the presence of high density material in the LMC N159W region., Comment: Accepted for publication to A&A. 14 pages, 7 figures (3 in Color), 3 tables. A version with high resolution figures available at http://www.astro.uni-bonn.de/~jopineda/pega/n159w_paper.pdf
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- 2008
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13. 12CO 4-3 and [CI] 1-0 at the centers of NGC 4945 and Circinus
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Hitschfeld, M., Aravena, M., Kramer, C., Bertoldi, F., Stutzki, J., Bensch, F., Bronfman, L., Cubick, M., Fujishita, M., Fukui, Y., Graf, U. U., Honingh, N., Ito, S., Jakob, H., Jacobs, K., Klein, U., Koo, B. -C., May, J., Miller, M., Miyamoto, Y., Mizuno, N., Onishi, T., Park, Y. -S., Pineda, J. L., Rabanus, D., Roellig, M., Sasago, H., Schieder, R., Simon, R., Sun, K., Volgenau, N., Yamamoto, H., and Yonekura, Y.
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Astrophysics - Abstract
Studying molecular gas in the central regions of the star burst galaxies NGC4945 and Circinus enables us to characterize the physical conditions and compare them to previous local and high-z studies. We estimate temperature, molecular density and column densities of CO and atomic carbon. Using model predictions we give a range of estimated CO/C abundance ratios. Using the new NANTEN2 4m sub-millimeter telescope in Pampa La Bola, Chile, we observed for the first time CO 4-3 and [CI] 3P1-3 P0 at the centers of both galaxies at linear scale of 682 pc and 732 pc respectively. We compute the cooling curves of 12CO and 13CO using radiative transfer models and estimate the physical conditions of CO and [CI]. The centers of NGC4945 and Circinus are very [CI] bright objects, exhibiting [CI] 3P1 - 3 P0 luminosities of 91 and 67Kkms-1kpc2, respectively. The [CI] 3P1-3 P0/CO 4-3 ratio of integrated intensities are large at 1.2 in NGC4945 and 2.8 in Circinus. Combining previous CO J= 1-0, 2-1 and 3-2 and 13CO J= 1-0, 2-1 studies with our new observations, the radiative transfer calculations give a range of densities, n(H2) = 10^3-3*104^cm-3, and a wide range of kinetic temperatures, Tkin = 20 - 100K, depending on the density. Future CO J= 7-6 and [CI] 2-1 observations will be important to resolve the ambiguity in the physical conditions and confirm the model predictions., Comment: 8 pages, 4 figures, accepted for publication in A&A
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- 2007
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14. Clumpy photon-dominated regions in Carina. I. [CI] and mid-J CO lines in two 4'x4' fields
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Kramer, C., Cubick, M., Roellig, M., Sun, K., Yonekura, Y., Aravena, M., Bensch, F., Benz, A., Bertoldi, F., Bronfman, L., Fujishita, M., Fukui, Y., Graf, U. U., Hitschfeld, M., Honingh, N., Ito, S., Jakob, H., Jacobs, K., Klein, U., Koo, B. -C., May, J., Miller, M., Miyamoto, Y., Mizuno, N., Onishi, T., Park, Y. -S., Pineda, J. L., Rabanus, D., Sasago, H., Schieder, R., Simon, R., Stutzki, J., Volgenau, N., and Yamamoto, H.
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Astrophysics - Abstract
The Carina region is an excellent astrophysical laboratory for studying the feedback mechanisms of newly born, very massive stars within their natal giant molecular clouds (GMCs) at only 2.35 kpc distance. We use a clumpy PDR model to analyse the observed intensities of atomic carbon and CO and to derive the excitation conditions of the gas. The NANTEN2-4m submillimeter telescope was used to map the [CI] 3P1-3P0, 3P2-3P1 and CO 4-3, 7-6 lines in two 4'x4' regions of Carina where molecular material interfaces with radiation from the massive star clusters. One region is the northern molecular cloud near the compact OB cluster Tr14, and the second region is in the molecular cloud south of etaCar and Tr16. These data were combined with 13CO SEST spectra, HIRES/IRAS 60um and 100um maps of the FIR continuum, and maps of 8um IRAC/Spitzer and MSX emission. We used the HIRES far-infrared dust data to create a map of the FUV field heating the gas. The northern region shows an FUV field of a few 1000 in Draine units while the field of the southern region is about a factor 10 weaker. We constructed models consisting of an ensemble of small spherically symmetric PDR clumps within the 38" beam (0.43pc), which follow canonical power-law mass and mass-size distributions. We find that an average local clump density of 2x10**5 cm-3 is needed to reproduce the observed line emission at two selected interface positions. Stationary, clumpy PDR models reproduce the observed cooling lines of atomic carbon and CO at two positions in the Carina Nebula., Comment: accepted by A&A
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- 2007
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15. A PDR-Code Comparison Study
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Roellig, M., Abel, N. P., Bell, T., Bensch, F., Black, J., Ferland, G. J., Jonkheid, B., Kamp, I., Kaufman, M. J., Bourlot, J. Le, Petit, F. Le, Meijerink, R., Morata, O., Ossenkopf, V., Roueff, E., Shaw, G., Spaans, M., Sternberg, A., Stutzki, J., Thi, W. -F., van Dishoeck, E. F., van Hoof, P. A. M., Viti, S., and Wolfire, M. G.
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Astrophysics - Abstract
We present a comparison between independent computer codes, modeling the physics and chemistry of interstellar photon dominated regions (PDRs). Our goal was to understand the mutual differences in the PDR codes and their effects on the physical and chemical structure of the model clouds, and to converge the output of different codes to a common solution. A number of benchmark models have been created, covering low and high gas densities and far ultraviolet intensities. The benchmark models were computed in two ways: one set assuming constant temperatures, thus testing the consistency of the chemical network and photo-processes, and a second set determining the temperature selfconsistently. We investigated the impact of PDR geometry and agreed on the comparison of results from spherical and plane-parallel PDR models. We identified a number of key processes governing the chemical network which have been treated differently in the various codes, and defined a proper common treatment. We established a comprehensive set of reference models for ongoing and future PDR model bench-marking and were able to increase the agreement in model predictions for all benchmark models significantly., Comment: 28 pages, 16 figures, see all benchmark data under: http://www.ph1.uni-koeln.de/pdr-comparison
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- 2007
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16. Submillimeter Wave Astronomy Satellite observations of comet 9P/Tempel 1 and Deep Impact
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Bensch, F., Melnick, G. J., Neufeld, D. A., Harwit, M., Snell, R. L., Patten, B. M., and Tolls, V.
- Subjects
Astrophysics - Abstract
On 4 July 2005 at 5:52 UT the Deep Impact mission successfully completed its goal to hit the nucleus of 9P/Tempel 1 with an impactor, forming a crater on the nucleus and ejecting material into the coma of the comet. NASA's Submillimeter Wave Astronomy Satellite (SWAS) observed the 1(10)-1(01) ortho-water ground-state rotational transition in comet 9P/Tempel 1 before, during, and after the impact. No excess emission from the impact was detected by SWAS and we derive an upper limit of 1.8e7 kg on the water ice evaporated by the impact. However, the water production rate of the comet showed large natural variations of more than a factor of three during the weeks before and after the impact. Episodes of increased activity with Q(H2O)~1e28 molecule/s alternated with periods with low outgassing (Q(H2O)<~5e27 molecule/s). We estimate that 9P/Tempel 1 vaporized a total of N~4.5e34 water molecules (~1.3e9 kg) during June-September 2005. Our observations indicate that only a small fraction of the nucleus of Tempel 1 appears to be covered with active areas. Water vapor is expected to emanate predominantly from topographic features periodically facing the Sun as the comet rotates. We calculate that appreciable asymmetries of these features could lead to a spin-down or spin-up of the nucleus at observable rates., Comment: 38 pages, 2 tables, 7 figures; Icarus, in press
- Published
- 2006
- Full Text
- View/download PDF
17. A KOSMA 7 deg^2 13CO 2--1 & 12CO 3--2 survey of the Perseus cloud
- Author
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Sun, K., Kramer, C., Ossenkopf, V., Bensch, F., Stutzki, J., and Miller, M.
- Subjects
Astrophysics - Abstract
Characterizing the spatial and velocity structure of molecular clouds is a first step towards a better understanding of interstellar turbulence and its link to star formation. We present observations and structure analysis results for a large-scale (~ 7.10 deg^2) 13CO J = 2--1 and 12 CO J = 3--2 survey towards the nearby Perseus molecular cloud observed with the KOSMA 3m telescope. We study the spatial structure of line-integrated and velocity channel maps, measuring the $\Delta$-variance as a function of size scale. We determine the spectral index $\beta$ of the corresponding power spectrum and study its variation across the cloud and across the lines. We find that the spectra of all CO line-integrated maps of the whole complex show the same index, $\beta$ ~ 3.1, for scales between about 0.2 and 3pc, independent of isotopomer and rotational transition. A complementary 2MASS map of optical extinction shows a noticeably smaller index of 2.6. In contrast to the overall region, the CO maps of individual subregions show a significant variation of $\beta$. The 12CO 3--2 data provide e.g. a spread of indices between 2.9 in L1455 and 3.5 in NGC1333. In general, active star forming regions show a larger power-law exponent. We find that the $\Delta$-variance spectra of individual velocity channel maps are very sensitive to optical depth effects clearly indicating self-absorption in the densest regions. When studying the dependence of the channel-map spectra as a function of the velocity channel width, the expected systematic increase of the spectral index with channel width is only detected in the blue line wings.This could be explained by a filamentary, pillar-like structure which is left at low velocities while the overall molecular gas is swept up by a supernova shock wave., Comment: 11 pages, 10 figures, accepted by A&A
- Published
- 2006
18. A map of OMC-1 in CO 9-8
- Author
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Marrone, D. P., Battat, J., Bensch, F., Blundell, R., Diaz, M., Gibson, H., Hunter, T., Meledin, D., Paine, S., Papa, D. C., Radford, S. J. E., Smith, M., and Tong, E.
- Subjects
Astrophysics - Abstract
The distribution of 12C16O J=9-8 (1.037 THz) emission has been mapped in OMC-1 at 35 points with 84" resolution. This is the first map of this source in this transition and only the second velocity-resolved ground-based observation of a line in the terahertz frequency band. There is emission present at all points in the map, a region roughly 4' by 6' in size, with peak antenna temperature dropping only near the edges. Away from the Orion KL outflow, the velocity structure suggests that most of the emission comes from the OMC-1 photon-dominated region, with a typical linewidthof 3-6 km/s. Large velocity gradient modeling of the emission in J=9-8 and six lower transitions suggests that the lines originate in regions with temperatures around 120 K and densities of at least 10^(3.5) cm^(-3) near theta^(1) C Ori and at the Orion Bar, and from 70 K gas at around 10^(4) cm^(-3) southeast and west of the bar. These observations are among the first made with the 0.8 m Smithsonian Astrophysical Observatory Receiver Lab Telescope, a new instrument designed to observe at frequencies above 1 THz from an extremely high and dry site in northern Chile., Comment: Minor changes to references, text to match ApJ version
- Published
- 2004
- Full Text
- View/download PDF
19. Deep Impact: Observations from a Worldwide Earth-Based Campaign
- Author
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Meech, K. J., Ageorges, N., Arpigny, C., Ates, A., Aycock, J., Bagnulo, S., Bailey, J., Barber, R., Barrera, L., Barrena, R., Bauer, J. M., Belton, M. J. S., Bensch, F., Bhattacharya, B., Biver, N., Blake, G., Bockelée-Morvan, D., Boehnhardt, H., Bonev, B. P., Bonev, T., Buie, M. W., Burton, M. G., Butner, H. M., Cabanac, R., Campbell, R., Campins, H., Capria, M. T., Carroll, T., Chaffee, F., Charnley, S. B., Cleis, R., Coates, A., Cochran, A., Colom, P., Conrad, A., Coulson, I. M., Crovisier, J., deBuizer, J., Dekany, R., de Léon, J., Russo, N. Dello, Delsanti, A., DiSanti, M., Drummond, J., Dundon, L., Etzel, P. B., Farnham, T. L., Feldman, P., Fernández, Y. R., Filipovic, M. D., Fisher, S., Fitzsimmons, A., Fong, D., Fugate, R., Fujiwara, H., Fujiyoshi, T., Furusho, R., Fuse, T., Gibb, E., Groussin, O., Gulkis, S., Gurwell, M., Hadamcik, E., Hainaut, O., Harker, D., Harrington, D., Harwit, M., Hasegawa, S., Hergenrother, C. W., Hirst, P., Hodapp, K., Honda, M., Howell, E. S., Hutsemékers, D., Iono, D., Jackson, W., Jehin, E., Jiang, Z. J., Jones, G. H., Jones, P. A., Kadono, T., Kamath, U. W., Käufl, H. U., Kasuga, T., Kawakita, H., Kelley, M. S., Kerber, F., Kidger, M., Kinoshita, D., Knight, M., Lara, L., Larson, S. M., Lederer, S., Levasseur-Regourd, A. C., Li, J. Y., Licandro, J., Lisse, C. M., LoCurto, G., Lovell, A. J., Lowry, S. C., Lyke, J., Lynch, D., Ma, J., Magee-Sauer, K., Maheswar, G., Manfroid, J., Marco, O., Martin, P., Melnick, G., Miller, S., Miyata, T., Moriarty-Schieven, G. H., Moskovitz, N., Mueller, B. E. A., Mumma, M. J., Muneer, S., Neufeld, D. A., Ootsubo, T., Osip, D., Pandea, S. K., Pantin, E., Paterno-Mahler, R., Patten, B., Penprase, B. E., Peck, A., Petitas, G., Pinilla-Alonso, N., Pittichova, J., Pompei, E., Prabhu, T. P., Qi, C., Rao, R., Rauer, H., Reitsema, H., Rodgers, S. D., Rodriguez, P., Ruane, R., Ruch, G., Rujopakarn, W., Sahu, D. K., Sako, S., Sakon, I., Samarasinha, N., Sarkissian, J. M., Saviane, I., Schirmer, M., Schultz, P., Schulz, R., Seitzer, P., Sekiguchi, T., Selman, F., Serra-Ricart, M., Sharp, R., Snell, R. L., Snodgrass, C., Stallard, T., Stecklein, G., Sterken, C., Stüwe, J. A., Sugita, S., Sumner, M., Suntzeff, N., Swaters, R., Takakuwa, S., Takato, N., Thomas-Osip, J., Thompson, E., Tokunaga, A. T., Tozzi, G. P., Tran, H., Troy, M., Trujillo, C., Van Cleve, J., Vasundhara, R., Vazquez, R., Vilas, F., Villanueva, G., von Braun, K., Vora, P., Wainscoat, R. J., Walsh, K., Watanabe, J., Weaver, H. A., Weaver, W., Weiler, M., Weissman, P. R., Welsh, W. F., Wilner, D., Wolk, S., Womack, M., Wooden, D., Woodney, L. M., Woodward, C., Yamashita, T., Yang, B., Yokogawa, S., Zook, A. C., Zauderer, A., Zhao, X., and Zhou, X.
- Published
- 2005
20. Submillimeter Wave Astronomy Satellite Observations of Comet 9P/Tempel 1
- Author
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Bensch, F., Melnick, G. J., Neufeld, D. A., Harwit, M., Snell, R. L., Patten, B. M., Tolls, V., Leibundgut, Bruno, editor, Käufl, H.U., editor, and Sterken, C., editor
- Published
- 2009
- Full Text
- View/download PDF
21. Molecular Clouds in Weak FUV Fields: Observations and PDR Model
- Author
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Bensch, F., Leuenhagen, U., Stutzki, J., Schieder, R., Pfalzner, Susanne, editor, Kramer, Carsten, editor, Straubmeier, Christian, editor, and Heithausen, Andreas, editor
- Published
- 2004
- Full Text
- View/download PDF
22. The KOSMA Multi-line CO Survey of Clouds in the Galactic Molecular Ring
- Author
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Brüll, M., Kramer, C., Ossenkopf, V., Stutzki, J., Simon, R., Bensch, F., Pfalzner, Susanne, editor, Kramer, Carsten, editor, Straubmeier, Christian, editor, and Heithausen, Andreas, editor
- Published
- 2004
- Full Text
- View/download PDF
23. Epitaxy and Magnetism of Fe and FeCo on Gaas(001) : Growth, Onset of Ferromagnetism and Magnetic Anisotropies
- Author
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Dumm, M., Bensch, F., Moosbühler, R., Zölfl, M., Brockmann, M., Bayreuther, G., and Hadjipanayis, George C., editor
- Published
- 2001
- Full Text
- View/download PDF
24. On the Fractal Structure of Molecular Clouds
- Author
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Stutzki, J., Heithausen, A., Bensch, F., Latter, William B., editor, Radford, Simon J. E., editor, Jewell, Philip R., editor, Mangum, Jeffrey G., editor, and Bally, John, editor
- Published
- 1997
- Full Text
- View/download PDF
25. Immune Checkpoint Inhibitor Dose Adaptation During the COVID-19 Pandemic in Non-Small Cell Lung Cancer: a Single-Center Experience
- Author
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Hijmering-Kappelle, L., Hiltermann, T. J. N., Bensch, F., and Translational Immunology Groningen (TRIGR)
- Subjects
covid-19 ,immune checkpoint inhibitor ,NSCLC - Published
- 2021
26. Water and related chemistry in the solar system. A guaranteed time key programme for Herschel
- Author
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Hartogh, P., Lellouch, E., Crovisier, J., Banaszkiewicz, M., Bensch, F., Bergin, E.A., Billebaud, F., Biver, N., Blake, G.A., Blecka, M.I., Blommaert, J., Bockelée-Morvan, D., Cavalié, T., Cernicharo, J., Courtin, R., Davis, G., Decin, L., Encrenaz, P., Encrenaz, T., González, A., de Graauw, T., Hutsemékers, D., Jarchow, C., Jehin, E., Kidger, M., Küppers, M., de Lange, A., Lara, L.-M., Lis, D.C., Lorente, R., Manfroid, J., Medvedev, A.S., Moreno, R., Naylor, D.A., Orton, G., Portyankina, G., Rengel, M., Sagawa, H., Sánchez-Portal, M., Schieder, R., Sidher, S., Stam, D., Swinyard, B., Szutowicz, S., Thomas, N., Thornhill, G., Vandenbussche, B., Verdugo, E., Waelkens, C., and Walker, H.
- Published
- 2009
- Full Text
- View/download PDF
27. OA01.03 Immune Checkpoint Inhibitor Dose Adaptation During the COVID-19 Pandemic in Non-Small Cell Lung Cancer– a Single-Center Experience
- Author
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Hijmering-Kappelle, L., primary, Hiltermann, T.j.n., additional, and Bensch, F., additional
- Published
- 2021
- Full Text
- View/download PDF
28. Process integration of infrared-sensitive PIN photodiodes and CMOS transistors in a single-SiGe substrate
- Author
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Nebrich, L., Neumeier, K., Stadler, A., Weber, J., Bensch, F., Kreuzer, S., Vogg, G., Herrmann, K., Klumpp, A., Wieland, R., Bonfert, D., Soldner, W., and Ramm, P.
- Published
- 2005
- Full Text
- View/download PDF
29. High quality strained Si/SiGe substrates for CMOS and optical devices
- Author
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Weber, J., Nebrich, L., Bensch, F., Neumeier, K., Vogg, G., Wieland, R., Bonfert, D., and Ramm, P.
- Published
- 2005
- Full Text
- View/download PDF
30. CHARACTERIZATION OF MOLECULAR CLOUD STRUCTURE
- Author
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OSSENKOPF, V., primary, BENSCH, F., additional, and STUTZKI, J., additional
- Published
- 2000
- Full Text
- View/download PDF
31. Quantum oscillations of properties in magnetic multilayers
- Author
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Bayreuther, G., Bensch, F., and Kottler, V.
- Subjects
Thin films, Multilayered -- Evaluation ,Magnetization -- Analysis ,Electromagnetic interference -- Analysis ,Physics - Published
- 1996
32. The KOSMA Multi-line CO Survey of Clouds in the Galactic Molecular Ring
- Author
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Brüll, M., primary, Kramer, C., additional, Ossenkopf, V., additional, Stutzki, J., additional, Simon, R., additional, and Bensch, F., additional
- Published
- 1997
- Full Text
- View/download PDF
33. Molecular Clouds in Weak FUV Fields: Observations and PDR Model
- Author
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Bensch, F., primary, Leuenhagen, U., additional, Stutzki, J., additional, and Schieder, R., additional
- Published
- 1997
- Full Text
- View/download PDF
34. Decalcification of Breast Cancer Bone Metastases With EDTA Does Not Affect ER, PR, and HER2 Results
- Author
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van Es, S.C., Vegt, B. (Bert) van der, Bensch, F., Gerritse, S., van Heiden, E.J., Boon, E., Angus, L., Overbosch, J., van Oordt, C., Verheul, HM, van Herpen, C.M., Jager, A. (Agnes), Oosting, SF, de Vries, E.G., Schroder, CP, van Es, S.C., Vegt, B. (Bert) van der, Bensch, F., Gerritse, S., van Heiden, E.J., Boon, E., Angus, L., Overbosch, J., van Oordt, C., Verheul, HM, van Herpen, C.M., Jager, A. (Agnes), Oosting, SF, de Vries, E.G., and Schroder, CP
- Abstract
In metastatic breast cancer (MBC), expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) guides treatment selection. In case of bone-only metastatic disease, ER, PR, and HER2 status assessment may be hampered by decalcification. We aimed to determine the optimal decalcification method, and to study discordance of receptor expression between paired primary breast tumors and optimally decalcified bone metastases. First, decalcification was simulated using acetic acid, hydrochloric/formic acid, and EDTA on 12 primary breast carcinomas. ER, PR, and HER2 immunohistochemistry (IHC) and HER2 in situ hybridization (ISH) were assessed, before and after the 3 decalcification methods. EDTA was considered the optimal method, as it did not affect IHC and as ISH failed in only 1/16 cases. Hydrochloric/formic acid altered ER and PR results, and, with acetic acid and hydrochloric/formic acid, ISH failed in, respectively, 94% and 100%. Second, ER, PR, and HER2 IHC was performed in paired primary tumors and EDTA-decalcified bone metastases obtained from patients with first presentation of MBC. Clinically relevant discordance was defined as changed receptor status with treatment implications. Paired samples of 77 patients, participating in the IMPACT-MBC trial, were evaluable. Hormonal receptor expression change was clinically relevant in 6 patients (7.9%) and HER2 expression change in 1 patient (1.3%). This study shows that EDTA decalcification minimally affects receptor expression results. The incidence of clinically relevant discordance between the primary tumor and bone metastases is low. These findings support that bone biopsies can reliably be used to assess receptor status.
- Published
- 2019
- Full Text
- View/download PDF
35. Decalcification of Breast Cancer Bone Metastases With EDTA Does Not Affect ER, PR, and HER2 Results
- Author
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van Es, SC, van der Vegt, B, Bensch, F, Gerritse, S, van Heiden, EJ, Boon, E, Angus, L (Lindsay), Overbosch, J, van Oordt, C, Verheul, HM, van Herpen, CM, Jager, Agnes, Oosting, SF, Vries, EG, Schroder, CP, van Es, SC, van der Vegt, B, Bensch, F, Gerritse, S, van Heiden, EJ, Boon, E, Angus, L (Lindsay), Overbosch, J, van Oordt, C, Verheul, HM, van Herpen, CM, Jager, Agnes, Oosting, SF, Vries, EG, and Schroder, CP
- Published
- 2019
36. Onset of magnetic anisotropy in epitaxial Fe films on GaAs(001)
- Author
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Bensch, F., Moosbuhler, R., and Bayreuther, G.
- Subjects
Anisotropy -- Analysis ,Ferromagnetism -- Analysis ,Gallium arsenide -- Magnetic properties ,Physics - Abstract
The connection between the onset of ferromagnetism with an onset of magnetic anisotropy is examined. Ferromagnetic long-range order and uniaxial magnetic anisotropy appear for T >0 above a critical thickness of 2.5 ML suggesting the strong correlation between the onset of ferromagnetism and of magnetic anisotropy for Fe on GaAs(001).
- Published
- 2002
37. Epitaxial Fe films on GaAs(001): does the substrate surface reconstruction affect the uniaxial magnetic anisotropy?
- Author
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Moosbuhler, R., Bensch, F., Dumm, M., and Bayreuther, G.
- Subjects
Anisotropy -- Analysis ,Molecular beams -- Analysis ,Gallium arsenide -- Magnetic properties ,Physics - Abstract
The relation between the strong uniaxial magnetic anisotropy of Fe/GaAs(001) with the specific GaAs(001) surface reconstruction is examined. The easy axis of the uniaxial anisotropy is found along [110] in Fe(001) films grown by molecular-beam epitaxy on Ga-rich GaAs(001) surfaces at room temperature.
- Published
- 2002
38. Onset of ferromagnetism in Fe epitaxially grown on GaAs(001) (4x2) and (2x6)
- Author
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Bensch, F., Garreau, G., Moosbuhler, R., Bayreuther, G., and Beaurepaire, E.
- Subjects
Ferromagnetism -- Research ,Thin films -- Magnetic properties ,Physics - Abstract
It has been possible to grow ultrathin Fe films epitaxially at room temperature on GaAs(001) with either predominant (4x2) or (2x6) surface reconstruction. The onset of ferromagnetism was shown at a nominal Fe coverage of 2.5 monolayers.
- Published
- 2001
39. In-plane magnetic anisotropies in Fe films on vicinal Ag(001) and Au(001) surfaces
- Author
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Leeb, T., Brockmann, M., Bensch, F., Miethaner, S., and Bayreuther, G.
- Subjects
Magnetism -- Research ,Iron -- Research ,Thin films -- Magnetic properties ,Epitaxy -- Research ,Physics - Abstract
A study was conducted to analyze in-plane fourfold and uniaxial magnetic anisotropies in iron films. The films were grown epitaxially on vicinal Ag(001) and Au(001) surfaces prepared by molecular beam epitaxy on miscut GaAs(001) substrates. the residual pressure in the chamber remained below 5x10(super -10) mbar during film deposition. Experimental results indicated that the orientation of the uniaxial easy axis correlated with the iron thickness.
- Published
- 1999
40. In-plane spin reorientation transition in ultrathin epitaxial Fe(001) films
- Author
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Brockmann, M., Miethaner, S., Onderka, R., Kohler, M., Himmelhuber, F., Regensburger, H., Bensch, F., Schweinbock, T., and Bayreuther, G.
- Subjects
Magnetic media -- Research ,Thin films -- Magnetic properties ,Physics - Published
- 1997
41. Capsule Transport Evaluation of a Rapid He-Transfer System with a 6LiD-Converter
- Author
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Salahi, A., Grass, F., Bensch, F., Zugarek, G., Schmidt, J. O., von der Hardt, Peter, editor, and Röttger, Heinz, editor
- Published
- 1983
- Full Text
- View/download PDF
42. IMPACT: op weg naar een gepersonaliseerde antikankerbehandeling met behulp van moleculaire beeldvorming. Drie lopende studies voor mamma-, colorectaal en niercelcarcinoom
- Author
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van Helden, E.J., van Es, S.C., Bensch, F., Boon, E., van der Houven van Oordt, C.W., Schroder, C.P., van Herpen, C.M.L., Brouwers, A.H., Glaudemans, A.W.J.M., Hoekstra, O.S., Oyen, W.J.G., van der Graaf, W.T.A., Verheul, H.M.W., de Vries, E.G.E., Medical oncology, CCA - Disease profiling, and Radiology and nuclear medicine
- Published
- 2015
43. 1627PPET-IMAGING WITH 89ZR-LABELED ANTI-MESOTHELIN (MSLN) ANTIBODY IN PATIENTS WITH PANCREATIC CANCER (PC) OR OVARIAN CANCER (OC)
- Author
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Lamberts, L.E., Menke-van der Houven van Oordt, C.W., Bensch, F., Voortman, J., Hoekstra, O.S., Maslyar, D., Williams, S.P., Fine, B.M., Bongaerts, A.H., Gietema, J.A., Schroder, C.P., Weele, E.J. Ter, Hooge, M.N. Lub-De, Verheul, H.M., Sanabria, S., Glaudemans, A.W.J.M., De Vries, E., Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Translational Immunology Groningen (TRIGR), Medical oncology, CCA - Innovative therapy, Radiology and nuclear medicine, and Internal medicine
- Abstract
Aim: The tumor antigen MSLN is frequently overexpressed in PC and OC. A 89Zr-PET study (NCT01832116) with MMOT0530A, an anti-MSLN antibody, was initiated in conjunction with a phase 1 study of the antibody-drug conjugate DMOT4039A (containing MMOT0530A linked to the anti-mitotic agent MMAE, NCT01469793). This imaging study aims to investigate antibody tumor uptake, whole body distribution and organ pharmacokinetics and to explore the relation between uptake and MSLN expression and response to DMOT40392A treatment in patients with unresectable PC or platinum-resistant OC. Methods: Before receiving DMOT4039A, patients were injected with 37 MBq 89Zr-MMOT0530A +/- additional unlabeled MMOT0530A, followed by PET/CT imaging 2, 4 and 7 days post injection (pi). Tracer uptake was quantified with standardized uptake value (SUV) and expressed as mean (±SD). MSLN expression was determined in archival tumor tissue with an exploratory immunohistochemical (IHC) assay. Results: 7 PC and 4 OC patients were included. MSLN expression varied from 0 to 3+. The optimal antibody protein dose resulting in sufficient circulating tracer was 10 mg MMOT0530A and the optimal imaging time was 4 or 7 days pi. Tumor tracer uptake was observed in 37 quantifiable tumor lesions (all patients) with mean SUV of 10.7 (±6.3) on PET 4 days pi. The mean SUV per patient (1-8 lesions/patient) was 10.9 (±5.7), with 9.2 (±4.5) in PC and 11.9 (±7.4) in OC lesions on PET 4 days pi. Within patients, a mean 2.4-fold (±1.10) difference in tumor uptake between lesions was found. Two measurable lesions on diagnostic CT (according to RECIST 1.1) were not visible on PET. Uptake in blood, liver, kidneys, spleen and intestine reflected normal antibody distribution with mean SUV at day 4 pi of 5.6, 7.8, 6.1, 4.1 and 3.2, respectively, while low uptake was observed in muscle, lung, brain and bone (0.6, 1.0, 0.2 and 0.7, respectively). Tracer tumor uptake was lower in the 2 patients with IHC scores 0 and 1. Best response on DMOT4039A was stable disease in ten patients. An association between iPET tumor uptake and clinical response could not be determined. Conclusions: 89Zr-MMOT0530A-PET shows antibody uptake in primary and metastatic PC and OC tumor lesions. This technique can potentially guide antibody-based therapy development.
- Published
- 2014
- Full Text
- View/download PDF
44. HER3, serious partner in crime: therapeutic approaches and potential biomarkers for effect of HER3-targeting
- Author
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Kol A, Terwisscha van Scheltinga AG, Timmer-Bosscha H, Lamberts LE, Bensch F, de Vries EG, and Schroder CP
- Published
- 2014
45. Selection to targeted treatment in advanced disease
- Author
-
de Vries, Liesbeth, van Kruchten, M., Lamberts, L., Bensch, F., Brouwers, A., Lub-de-Hooge, M., van Dam, G., Schroder, C., Hospers, G., Microbes in Health and Disease (MHD), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
- Published
- 2014
46. Abstract P5-03-06: Clinical value of 89Zr-trastuzumab PET in HER2-positive breast cancer patients with a clinical dilemma
- Author
-
Schröder, CP, primary, Bensch, F, additional, Brouwers, AH, additional, Lub-de Hooge, MN, additional, de Jong, JR, additional, van der Vegt, B, additional, Sleijfer, S, additional, and de Vries, EG, additional
- Published
- 2017
- Full Text
- View/download PDF
47. Neutron-physical aspects of an incore generator for 14 MeV neutrons
- Author
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Zillner, K. and Bensch, F.
- Published
- 1981
- Full Text
- View/download PDF
48. Epitaxial Fe films on GaAs(001): Does the substrate surface reconstruction affect the uniaxial magnetic anisotropy?
- Author
-
Moosbu¨hler, R., Bensch, F., Dumm, M., and Bayreuther, G.
- Subjects
- *
MAGNETISM , *ANISOTROPY - Abstract
The in-plane magnetic anisotropy of Fe films epitaxially grown on GaAs(001), in addition to a thickness-dependent four-fold contribution has a uniaxial component originating from the Fe/GaAs interface. This has been observed in several previous investigations. The orientation of the uniaxial easy axis (e.a.), however, was found to be along the [110] direction in most studies, but also an e.a. parallel to [-110] was reported in a few cases. It has been suggested that different reconstructions of the GaAs surface prior to Fe deposition could be responsible for this discrepancy. In the present contribution, it is shown that in Fe(001) films grown by molecular-beam epitaxy on Ga-rich GaAs(001) surfaces at room temperature the uniaxial anisotropy always has its easy axis along [110] with practically the same magnitude. In particular, the surface reconstruction of the GaAs substrate either (4×2) or (2×6) — has no effect on the resulting uniaxial magnetic anisotropy. This [together with recent results related to the phase transition of Fe/GaAs(001)] suggests that the same atomic configuration is formed at the Fe/GaAs(001) interface in both cases connected with the segregation of a certain amount of As (and Ga) to the surface. [ABSTRACT FROM AUTHOR]
- Published
- 2002
- Full Text
- View/download PDF
49. Magnetic moments and anisotropies in ultrathin epitaxial Fe films on ZnSe(001).
- Author
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Reiger, E., Reinwald, E., Garreau, G., Ernst, M., Zo¨lfl, M., Bensch, F., Bauer, S., Preis, H., and Bayreuther, G.
- Subjects
THIN films ,ANISOTROPY ,MOLECULAR beam epitaxy ,ELECTRON diffraction - Abstract
The morphology, atomic magnetic moments, and in-plane magnetic anisotropies of ultrathin bcc Fe(001) films deposited by molecular beam epitaxy on ZnSe epilayers grown on GaAs(001) single crystal are reported. The growth mode and structure have been determined in situ by means of reflection high energy electron diffraction and Auger electron spectroscopy. The magnetic properties were characterized ex situ by an alternating gradient magnetometer, superconducting quantum interference device (SQUID) magnetometry, and conversion electron Mo¨ssbauer spectroscopy (CEMS). The Fe growth is epitaxial and occurs by three dimensional nucleation at the beginning. The coalescence of the islands is observed around 7 monolayers (ML). In agreement with SQUID results, CEMS measurements indicate no reduction of the Fe magnetic moment compared to the bulk value even for the first Fe monolayers. Determination of the in-plane anisotropy constants as function of the Fe thickness shows a strong interface-induced uniaxial in-plane magnetic anisotropy, which leads to a continuous evolution from a pure uniaxial anisotropy with easy axis along [110] direction for thickness below 10 ML to the pure bulk cubic Fe anisotropy above 40 ML. © 2000 American Institute of Physics. [ABSTRACT FROM AUTHOR]
- Published
- 2000
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50. Submillimeter Wave Astronomy Satellite Observations of Comet 9P/Tempel 1
- Author
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Bensch, F., primary, Melnick, G. J., additional, Neufeld, D. A., additional, Harwit, M., additional, Snell, R. L., additional, Patten, B. M., additional, and Tolls, V., additional
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